Medicine and Health Sciences Commons^™

A Novel Prognostic 7-Methylguanosine Signature Reflects Immune Microenvironment And Alternative Splicing In Glioma Based On Multi-Omics Analysis, Zihan Wang, Zhiwei Zhong, Zehua Jiang, Zepeng Chen, Yuequn Chen, Yimin Xu

Research outputs 2022 to 2026

Glioma is the most common type of central nervous system tumor with increasing incidence. 7-methylguanosine (m7G) is one of the diverse RNA modifications that is known to regulate RNA metabolism and its dysregulation was associated with various cancers. However, the expression pattern of m7G regulators and their roles in regulating tumor immune microenvironments (TIMEs) as well as alternative splicing events (ASEs) in glioma has not been reported. In this study, we showed that m7G regulators displayed a close correlation with each other and most of them were differentially expressed between normal and glioma tissues. Two m7G signatures were then constructed …

Increased Expression Of Interferon-Induced Transmembrane 3 (Ifitm3) In Stroke And Other Inflammatory Conditions In The Brain, Elisabeth Harmon, Andrea Doan, Jesus Bautista-Garrido, Joo Eun Jung, Sean P Marrelli, Gab Seok Kim

Faculty, Staff and Student Publications

Microglia, the resident innate immune cells of the brain, become more highly reactive with aging and diseased conditions. In collaboration with other cell types in brains, microglia can contribute both to worsened outcome following stroke or other neurodegenerative diseases and to the recovery process by changing their phenotype toward reparative microglia. Recently, IFITM3 (a member of the "interferon-inducible transmembrane" family) has been revealed as a molecular mediator between amyloid pathology and neuroinflammation. Expression of IFITM3 in glial cells, especially microglia following stroke, is not well described. Here, we present evidence that ischemic stroke causes an increase in IFITM3 expression along …

Extracorporeal Membrane Oxygenation Therapy In Covid-19 Patients With Acute Respiratory Distress Syndrome, Joseph B. Zwischenberger, Katherine Breetz

Journal of Shock and Hemodynamics

Patients with coronavirus disease of 2019 (COVID-19) may present with a wide range of symptoms ranging from asymptomatic to critically ill. Approximately 10-14% of patients require hospitalization. Those individuals requiring hospitalization can deteriorate rapidly with worsening hypoxemia or new-onset pneumonia, resulting in 20-30% of patients developing acute respiratory distress syndrome (ARDS).

When refractory to medical management, severe ARDS secondary to other illnesses has been successfully treated with extracorporeal membrane oxygenation (ECMO). We completed a comprehensive literature review of ECMO utilization for patients with severe COVID-19 who were unresponsive to critical care management. Of the 1419 patients with a reported diagnosis …

2022-08-09_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus/stats/coronavirus-symptoms. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated twice a week on Mondays and Thursdays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, …

2022-08-09_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/data-about-places/long-term-care-data.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …

2022-08-09_Michiganoverview_Isdreporting, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The K-12 Aged ISD Reporting page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/k-to-12-aged-isd-reporting.

This report is created from data reported by the Michigan Disease Surveillance System (MDSS) the Michigan Department of Health and Human Services' web-based communicable disease reporting system. Data is updated every week.

The purpose of the dashboard is to report the 7 day average of COVID-19 cases in Michigan school students aged 5 through 18 at the intermediate school district and school district levels, as well as display trends over time to better illustrate the changing nature of the COVID-19 pandemic. Cases are attributed to …

2022-08-09_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/stats.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted once a week on Tuesdays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) …

2022-08-09_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was downloaded as an Excel spreadsheet which appeared in the Public Use Datasets section under the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173---,00.html.

Cases are aggregated by the date of onset of COVID-19 symptoms, if known, otherwise by laboratory specimen date if known, otherwise by case referral date. Deaths are aggregated by the date of death if known, otherwise by the last date of a change to the case status.

Occupational Therapy Program For Pace Center For Girls, Natalie Vish

Department of Occupational Therapy Entry-Level Capstone Projects

An occupational therapy handbook was created for future occupational therapy students and occupational therapy assistant students to utilize when completing fieldwork rotations at Pace Center for Girls. The handbook was created to address core occupations through a trauma-informed and gender-sensitive perspective. An occupational therapy program utilizing mindfulness and sensory-based approaches at Pace Center for Girls may provide alternative and effective solutions for this at-risk female adolescent population as literature reveals that survivors of complex trauma often do not respond to traditional psychiatric treatment approaches.

Strategies For Enhancing Racially Diverse Student Satisfaction In Graduate-Level Occupational Therapy Programs, Kolbí L. Holmes, Christina Kane

Department of Occupational Therapy Entry-Level Capstone Projects

A survey investigated satisfaction levels of racially diverse, graduate-level OT students at NSU and strategies for enhancing student satisfaction to ultimately meet the OT profession’s diversity goals. Overall, racially diverse students were satisfied with their OT program experience and identified diverse faculty and scholarship opportunities as desired resources needed for continuation in OT programs.

Wearable Activity Trackers For Women: Motivating Factors For Increasing Physical Activity, Danielle A. Bate

Theses and Dissertations

Half of American women do not sustain recommended levels of physical activity (PA). Wearable activity trackers (WATs) may increase both awareness of, and PA if worn daily. Thus, WATs should include features and designs that encourage daily use. This study aimed to determine WAT features and designs most appealing to women and the motivational effects of various WATs. For this mixed-method pilot study, 15 women each trialed three WATs; documented daily PA levels; and rated their satisfaction with each device's comfort, features, and motivational effect. Additionally, participants shared experiences and feedback in focus groups. Features that promote adoption of WATs …

Mapping Parents' Journey Following Prenatal Diagnosis Of Chd: A Qualitative Study, Kelly W. Harris, Catherine Hammack-Aviran, Kathleen M. Brelsford, Ann Kavanaugh-Mchugh, Ellen Wright Clayton

Law Faculty Scholarship

This longitudinal qualitative study examines parental experiences following prenatal diagnosis of congenital heart disease (CHD). Researchers conducted 62 interviews with members of 17 families during pregnancy and after birth to understand emotional processing, coping strategies, and evolving informational needs. Parents initially sought to balance hope with efforts to comprehend the medical diagnosis and its implications. Over time, as prognostic uncertainty decreased following birth, parents reported increased desire for active involvement in decision-making and clinical care planning. The study identifies shifts in emotional orientation and informational priorities across the prenatal and postnatal periods. These findings suggest that clinicians should tailor communication …

Covid-19 Newsletter (Vol. 131), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Adolescent-Reported Household Food Insecurity And Adolescents' Poor Mental And Physical Health And Food Insufficiency In Kenya, Amanda S. Mcrell, Maryah S. Fram, Edward A. Frongillo Jr.

Faculty Publications

Background

Objectives

Methods

The Use Of Self-Efficacy Evaluations, Self-Care Evaluations, And Motivational Interviewing To Improve Glycated Hemoglobin Values In Type 2 Diabetes Mellitus, Meredith Ann Kelley

Doctoral Dissertations and Projects

When improperly managed, type 2 diabetes mellitus is a serious and chronic health condition with far-reaching repercussions for individuals, families, and societies. In the United States, 34.2 million individuals live with diabetes, and 90%-95% have type 2 diabetes. While the United States healthcare system faces the monumental task of improving diabetic care outcomes and associated costs, publications have established that motivational interviewing (MI) can improve self-efficacy and associated self-care behaviors of type 2 diabetics, resulting in improved hemoglobin A1c values. Thus, this scholarly project’s intent was to track participant hemoglobin A1c values over three months, measure participant self-efficacy and self-care …

Native American Mental Health: Adding Culture To The Conversation, Margaret Rose

Population Health Research Brief Series

American Indians/Alaska Natives (AI/ANs) experience higher rates of depression, suicide, and psychological distress compared to other communities in the United States. Despite this, they are less likely to receive mental health services due to barriers such as lack of resources, limited mental health service access, stigma, and mistrust of providers. This issue brief describes the influence of colonialism on AI/AN mental health and discusses how barriers to mental health treatment can be addressed by integrating AI/AN culture into traditional mental health services and increasing AI/AN presence in mental health occupations.

Grk2 Regulates Adp Signaling In Platelets Via P2y1 And P2y12., Xuefei Zhao, Matthew Cooper, James V Michael, Yanki Yarman, Aiden Baltz, J Kurt Chuprun, Walter J Koch, Steven E. Mckenzie, Maurizio Tomaiuolo, Timothy J Stalker, Li Zhu, Peisong Ma

Department of Medicine Faculty Papers

The critical role of G protein-coupled receptor kinase 2 (GRK2) in regulating cardiac function has been well documented for >3 decades. Targeting GRK2 has therefore been extensively studied as a novel approach to treating cardiovascular disease. However, little is known about its role in hemostasis and thrombosis. We provide here the first evidence that GRK2 limits platelet activation and regulates the hemostatic response to injury. Deletion of GRK2 in mouse platelets causes increased platelet accumulation after laser-induced injury in the cremaster muscle arterioles, shortens tail bleeding time, and enhances thrombosis in adenosine 5'-diphosphate (ADP)-induced pulmonary thromboembolism and in FeCl3-induced carotid …

Inhibition Of Cdk8/19 Mediator Kinase Potentiates Her2-Targeting Drugs And Bypasses Resistance To These Agents In Vitro And In Vivo, Xiaokai Ding, Amanda C. Sharko, Martina S.J. Mcdermott, Gary P. Schools, Alexander Chumanevich, Hao Ji, Jing Li, Li Zhang, Zachary T. Mack, Vitali Sikirzhytski, Michael Shtutman, Laura Ivers, Norma O'Donovan, John Crown, Balazs Gyorffy, Mengqian Chen, Igor Roninson, Eugenia Broude

Faculty Publications

Breast cancers (BrCas) that overexpress oncogenic tyrosine kinase receptor HER2 are treated with HER2-targeting antibodies (such as trastuzumab) or small-molecule kinase inhibitors (such as lapatinib). However, most patients with metastatic HER2⁺BrCa have intrinsic resistance and nearly all eventually become resistant to HER2-targeting therapy. Resistance to HER2-targeting drugs frequently involves transcriptional reprogramming associated with constitutive activation of different signaling pathways. We have investigated the role of CDK8/19 Mediator kinase, a regulator of transcriptional reprogramming, in the response of HER2⁺BrCa to HER2-targeting drugs. CDK8 was in the top 1% of all genes ranked by correlation with shorter relapse-free …

Impact Of Resiliency Training On Combating Burnout, Kimberly Labinsky

MSN Capstone Projects

Occupational burnout has long since been a problem but has only recently been acknowledged as the spark behind the fire that has led to our critical nursing shortage. Considering the emotional aftermath of the pandemic and the hardships that a strained economy will bring, we must learn how to extinguish these flames rather than adding fuel to this complex problem. Burnout is causing a vicious cycle within the healthcare workforce that will lead to detrimental effects on quality patient care. We must learn how to break the cycle.

The cycle starts with experienced nurses leaving unprecedented numbers and units primarily …

Comparative Study Between Minimally Invasive Right Anterior Mini-Thoracotomy Versus Conventional Median Sternotomy In Isolated Aortic Valve Replacement: Early Outcome, Ashraf Abdelaziz, Hazem G. Bakr, Ibrahim M. Helmi

Journal of Medicine in Scientific Research

Background In cardiac surgery, minimally invasive surgical procedures have recently been adopted. These innovative procedures have a number of benefits, including less postoperative discomfort, fewer morbidity and mortality, faster recovery, and shorter hospital stays at lower costs. Patients and methods Outcomes of 30 patients who underwent isolated aortic valve replacement, were subjected to a prospective comparative study, were compared. In group A (n = 15) minimally invasive right anterior mini-thoracotomy approach and in group B (n = 15) conventional median sternotomy approach had been used. Results The second group had much higher total morbidity than the first. In …

Environmental Metagenomic Assessment And Its Usefulness In The Present Pandemic, Pathum Sookaromdee, Viroj Wiwanitkit

Journal of Medicine in Scientific Research

No abstract provided.

Conventional Transradial Access Versus Distal Transradial Access For Coronary Angiography And Interventions, Ahmed K. A. Ghany Hassan

Journal of Medicine in Scientific Research

Introduction For so many years, femoral access has been the standard access for all interventional cardiologists performing coronary angiography and percutaneous coronary interventions. In the past 15 years, radial access gained more fame over femoral access as it has a lower risk of bleeding and it is more convenient to patients due to early mobilization and less hospital stay. Recently, the distal transradial access in the anatomical snuffbox has emerged as a new access for coronary procedures that carries some advantages over the standard proximal transradial access. These advantages include radial artery preservation in patients who may use radial artery …

Association Between Vitamin D Receptor Gene (Bsmi-Rs1544410 And Foki-Rs2228570) Polymorphisms And Type 1 Diabetes Mellitus In Egyptian Children, Abeer M. Mohyi, Dina M. El-Abd, Eman A. Rashed, Ghada A. Omar, Mona M. A. Abdullatif

Journal of Medicine in Scientific Research

Introduction Type 1 diabetes mellitus (T1DM) is an autoimmune disorder triggered by both environmental and genetic risk factors. Although some studies have reported that single-nucleotide polymorphisms of vitamin D receptor (VDR) gene play a role in T1DM susceptibility, their associations are inconclusive and remain controversial in different ethnic groups. This case–control study aimed to evaluate the association between VDR (BsmI-rs1544410 and FokI-rs2228570) single-nucleotide polymorphisms and T1DM in Egyptian children. A total of 100 participants, 50 children with T1DM (cases) and 50 nondiabetic, age-matched and sex-matched patients (controls), were enrolled in the study in which BsmI-rs1544410 and …

Cytokine Profiling For Egyptian Diabetic Patients With Nephropathy, Abdel R. B. Abdel Gaffar, Ibrahim A. Emara, Rania Hassan Mohamed, Samar M. Samir

Journal of Medicine in Scientific Research

Background Evidence suggests that poor glycemic control is significantly associated with the development of microvascular complications of diabetes such as nephropathy. Studies have indicated that interleukin 17 (IL-17), interferon gamma-inducible protein 10 (IP-10), and IL-10 are important risk factors for nephropathy. This study aimed to evaluate the cytokine profile for diabetic patients with nephropathy. Patients and methods The study included 72 diabetic patients who were divided into two groups. Group 1 included diabetic patients without complications with an albumin creatinine ratio of less than or equal to 30, while group 2 included 36 diabetic patients with an albumin creatinine ratio …

Clinical Significance Of Evaluation Of Some Metabolic And Hematological Parameters In Patients With Sudden Sensorineural Hearing Loss, Eman S. Abd El-Gaffar, Gehan M. S. Abd El-Salam, Hala M. Abd El-Samad

Journal of Medicine in Scientific Research

Background Sudden sens orineural hearing loss (SSNHL) is a medical emergency, being mostly an idiopathic disease. Understanding the pathogenesis of SSNHL may help physicians for diagnosis and intervention. Objective The aim of the present study was to investigate some metabolic and hematological parameters in patients with SSNHL and related them to their clinical condition. Patients and methods The study was conducted on 50 patients with SSNHL and 20 age-matched and sex-matched controls. Both groups were subjected to audiological and laboratory evaluation of their fasting blood sugar (FBS), lipid profile, thyroid function test, neutrophil–lymphocyte ratio, and platelet–lymphocyte ratio. Moreover, the relation …

The Prevalence Of Pulmonary Aspergillosis In Coronavirus Disease 19 (Covid-19) Patients In Shebin El-Kom Teaching Hospital In Egypt, Asmaa M. Soliman, Elham T. Awad, Mariam A. Fouad

Journal of Medicine in Scientific Research

Background A high rate of invasive fungal infection has been demonstrated among critically COVID-19 ill patients admitted to the ICU, with high odds of mortality. Simple and rapid risk stratification methods are mandatory to recognize severe patients. Objectives The aims was to study the prevalence of invasive fungal infection in Corona virus disease 19 (COVID-19) patients, the effect of some inflammatory markers that lead to the development and progression of invasive fungal infection and to assess the value of PCR in early and rapid detection of invasive fungal infection in immune compromised patients with COVID-19. Methods This study was conducted …

Evaluation The Role Of Conventional And Xpert Mtb/Rif Assays As Point-Of-Care Tests Of Mycobacterium Tuberculosis Infections, Especially During The Covid-19 Pandemic In Menoufia, Egypt, Asmaa M. Soliman, Elham T. Awad, Mariam A. Fouad, Moatz M. Elhefnay

Journal of Medicine in Scientific Research

Background Tuberculosis (TB) is a destructive pulmonary disease, which was the most fatal infectious disease in the world for many years before the COVID-19 outbreak. During pandemic, COVID-19 was the main concern in every clinic and there were overlapping respiratory diseases resulting in delaying of the diagnosis and treatment of TB. Xpert MTB/RIF assay and Ziehl–Neelsen (ZN) stain are the most commonly used point-of-care test (POCT) assays for TB that were endorsed by WHO allowing a quick treatment turnaround time of a few minutes or hours, hence avoiding patient loss to follow-up. The aim of the study was to evaluate …

A Study On Ecg And Cardiac Functional Changes In Patients With B-Thalassemia Major, Ahmed Khamis, Omnia S. El-Din, Randa M. Darwish

Journal of Medicine in Scientific Research

Background Cardiovascular complications such as heart failure and arrhythmias caused by 'iron-overload' cardiomyopathy are a leading cause of death in patients with thalassemia major (TM). Aims The study aims to determine the prevalence of cardiac complications in patients with B-TM. This will include cardiac function and electrocardiologic changes, as well as an examination of the relationship between these cardiac complications and various factors, including iron overload, in a 5-year cross-sectional study. Patients and methods After approval by the General Organization of Teaching Hospitals and Institutes' Ethics Review Committee, 40 patients with B-TM and 20 normal children meeting the inclusion criteria …

Forced Expiratory Volume In The Third Second And Its Derivatives For Diagnosis Of Airway Obstruction In Obese Patients, Manal S. H. El Hussini, Mohamed S. El Hussieny

Journal of Medicine in Scientific Research

Background Spirometry is a simple diagnostic tool for pulmonary diseases, as obstructive pulmonary disorders, especially in obese. Obesity is an increasing worldwide public health concern that contributes to many respiratory problems that affect both large and small airways. The traditional use of forced expiratory volume in the first second (FEV1) and FEV1/forced vital capacity (FVC) in defining large-airflow obstruction may be confined not only by the limitation of FVC maneuver, but also by the long time to reach plateau flow rate in geriatrics and in patients with moderate-to-severe airflow obstruction. FEV3 and its derivatives FEV1/FEV3 and FEV3/FVC are used for …

Contraception And Family Planning: Knowledge, Attitude, Pattern Of Use, And Barriers Among Females In Gharbia Governorate, Egypt, Hesham M. Borg, Salwa A. Atlam, Walid M. Daoud

Journal of Medicine in Scientific Research

Aims Most contraceptive methods are designed to be used by women due to the paucity of effective contraceptive options for men. This study aimed to assess knowledge, attitude, and family-planning (FP) practice among women of reproductive-age group in Gharbia Governorate, Egypt. Materials and materials A self-administered questionnaire was developed and adapted from previous studies. Scores were used to assess the levels of knowledge, attitude, and practice concerning FP. Results The questionnaire was answered by 430 women. Current use of contraceptives was stated by 81.9%. The commonest methods included intrauterine device (44%), oral pills (20.7%), and injectables (8.4%). Knowledge was good, …