Medicine and Health Sciences Commons^™

Predictors Of Early Seizures After First Acute Stroke, Malik Muhammad Adil, Sumaira Nabi, Maryam Khalil, Zeeshan Munawar, Nayab Aslam, Zaid Waqar

Pakistan Journal of Neurological Sciences (PJNS)

Background and objective: There is a lack of local data regarding the frequency and predictors of early seizures after stroke. The objective of this study was to determine the frequency of early seizures after stroke and identify the predictors which lead to them after first acute stroke.

Methods: This cross-sectional observational study was conducted in the Department of Neurology, Pakistan Institute of Medical Sciences, Islamabad from October 2021 to June 2022. A total of 310 consecutive eligible patients of acute stroke were recruited. Key inclusion criteria included any patient of >20 years of age with confirmed diagnosis of stroke on …

Hypodensities Within Hematoma Predict Outcome After Spontaneous Intracerebral Hemorrhage, Maryam Khalil, Sumaira Nabi, Amjad Mahmood Khan, Zeeshan Munawar, Samar Naik, Zaid Waqar, Malik Muhammad Adil, Mazhar Badshah

Pakistan Journal of Neurological Sciences (PJNS)

Background and objective: Radial nerve is injured due to a variety of reasons. The objective of this study was to determine the clinical spectrum, risk factors and electrophysiologic aspect of radial nerve injury presenting to a tertiary care hospital in Lahore.

Methods: This descriptive prospective cross-sectional study was conducted at department of Neurology, Mayo hospital Lahore from July 2022 to December 2022 and comprised patients with isolated radial nerve injury on the basis of history and clinical examination regardless of their gender, above 15 years of age. NCS/EMG was done on a Japanese machine Nihon Kohden by an expert as …

Experience With Anti Nmda Receptor Antibody Encephalitis In A Tertiary Care Hospital In Pakistan, Haris Majid Rajput, Zaid Waqar, Muhammad Hassan, Neelma Naz Khattak, Umair Hassan, Iqra Athar, Mazhar Badshah Badshah

Pakistan Journal of Neurological Sciences (PJNS)

Background and objective: Anti NMDA receptor (Anti-NMDAR) antibody encephalitis is an increasingly recognized form of auto immune encephalitis. The objective of this study was to determine the demographic, clinical and laboratory factors associated with this syndrome.

Methods: All cases presenting to neurology, Pakistan institute of medical sciences, Islamabad, from June 2017 till January 2020 were reviewed retrospectively. Patients fulfilling the diagnostic criteria for Anti NMDA receptor (Anti-NMDAR) antibody encephalitis were included. All patients were evaluated with cerebrospinal fluid (CSF)routine examination, MRI brain, autoimmune encephalitis profile and for presence of oligoclonal bands (OCB) in CSF. Statistical analysis was done using SPSS …

Roundtable Discussion: 68-Year-Old Man With Mhspc, Jason M. Hafron

Articles

No abstract provided.

Case Discussion: 66-Year-Old Man With Low-Volume Prostate Cancer, Jason M. Hafron

Articles

An interview with Michigan Institute of Urology's Doctor Jason M. Hafron is presented. He presents a case of a 66-year-old male with low-volume prostate cancer to discuss his possible prognosis and the risk group he should be categorized. He explains his preferred approach to treat the patient like ordering a bone scan, computed tomography (CT) of the chest, abdomen and pelvis, and germline testing. He recommends some treatments for metastatic castration-sensitive prostate cancer (CSPC).

Helical Remodeling Augments 5-Lipoxygenase Activity In The Synthesis Of Proinflammatory Mediators, Eden M. Gallegos, Tanner D. Reed, Forge A. Mathes, Nelson V. Guevara, David B. Neau, Wei Huang, Marcia E. Newcomer, Nathaniel C. Gilbert

School of Medicine Faculty Publications

The synthesis of proinflammatory leukotrienes implicated in asthma, allergic rhinitis, and atherosclerosis is initiated by the enzyme 5-lipoxygenase (5-LOX). The crystal structure of human Stable-5-LOX revealed a conformation where the catalytic iron was inaccessible to bulk solvent as two aromatic residues on a conserved helix-α2 (Hα2) plugged the substrate access portal. Whether 5-LOX can also adopt a more open conformation has not been resolved. Here, we present a new conformation of 5-LOX where Hα2 adopts an elongated conformation equivalent to that described in other animal lipoxygenase structures. Our observation of the sigmoidal kinetic behavior of 5-LOX, which is indicative of …

Knee Joint Biomechanics During Gait Improve From 3 To 6 Months After Anterior Cruciate Ligament Reconstruction, Kelsey Neal, Jack R. Williams, Abdulmajeed Alfayyadh, Jacob J. Capin, Ashutosh Khandha, Kurt Manal, Lynn Snyder-Mackler, Thomas S. Buchanan

Physical Therapy Faculty Research and Publications

Gait alterations after anterior cruciate ligament reconstruction (ACLR) are commonly reported and have been linked to posttraumatic osteoarthritis development. While knee gait alterations have been studied at several time points after ACLR, little is known about how these biomechanical variables change earlier than 6 months after surgery, nor is much known about how they differ over the entire stance phase of gait. The purpose of this study was to examine knee gait biomechanical variables over their entire movement pattern through stance at both 3 and 6 months after ACLR and to study the progression of interlimb asymmetry between the two …

A Word From The Writing Team (September 2022), Pam Walter, Mfa, Liz Declan, Ma, Mfa

A Word From the Writing Team (Newsletter)

This issue includes:

• Upcoming Workshops
• Writing Opportunity

Generalisability Of Deep Learning Models In Low-Resource Imaging Settings: A Fetal Ultrasound Study In 5 African Countries, Carla Sendra-Balcells, V´Ictor M. Campello, Jordina Torrents-Barrena, Yahya Ali Ahmed, Mustafa Elattar, Benard Ohene Botwe, Pempho Nyangulu, William Stones, Sikolia Wanyonyi, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Most artificial intelligence (AI) research and innovations have concentrated in high-income countries, where imaging data, IT infrastructures and clinical expertise are plentiful. However, slower progress has been made in limited-resource environments where medical imaging is needed. For example, in Sub-Saharan Africa the rate of perinatal mortality is very high due to limited access to antenatal screening. In these countries, AI models could be implemented to help clinicians acquire fetal ultrasound planes for diagnosis of fetal abnormalities. So far, deep learning models have been proposed to identify standard fetal planes, but there is no evidence of their ability to generalise in …

Understanding Distruptive Change In Health Care: Perspectives From The Front Lines Of Covid, Wendy Vaughon

Dissertations and Theses

COVID-19 dramatically stressed an already overburdened healthcare system. Physicians, susceptible to burnout, bore the brunt of this threat as frontline providers. Limited data are available describing how the pandemic may have affected physician perceptions and beliefs, including experiences of burnout and plans to exit the field. Reddit, a social media website, allows physicians the ability to interact with their peers pseudonymously on a purpose-driven, publicly viewable subreddit (r/medicine). By providing a space for “physicians and other medical professionals” to interact, it is possible to observe unfiltered discourse.

This dissertation explores physician-peer discourse on Reddit prior to and during the COVID-19 …

Intentional Self-Harm Overdoses Before And During The Covid-19 Pandemic In Adolescents Managed By A Medical Toxicology Consultation Service, Samantha L. Gaetani Md, Natalie E. Ebeling-Koning Do, Nicholas S. Imperato, Katelyn Mclain, Derek J. Fikse Do, Gillian A. Beauchamp Md, Marna R. Greenberg Do, Mph, Facep, Alexandra Amaducci

Toxicology Division

No abstract provided.

Quality Assessment Of Optic Nerve Sheath Diameter Ultrasonography: Scoping Literature Review And Delphi Protocol, Mohammad I Hirzallah, Piergiorgio Lochner, Muhammad Ubaid Hafeez, Andrew G Lee, Christos Krogias, Deepa Dongarwar, Ramneek Manchanda, Lara Ouellette, Nicholas D Hartman, Michael Ertl, Felix Schlachetzki, Chiara Robba

Library Staff Publications

BACKGROUND AND PURPOSE: The optic nerve is surrounded by the extension of meningeal coverings of the brain. When the pressure in the cerebrospinal fluid increases, it causes a distention of the optic nerve sheath diameter (ONSD), which allows the use of this measurement by ultrasonography (US) as a noninvasive surrogate of elevated intracranial pressure. However, ONSD measurements in the literature have exhibited significant heterogeneity, suggesting a need for consensus on ONSD image acquisition and measurement. We aim to establish a consensus for an ONSD US Quality Criteria Checklist (ONSD US QCC).

METHODS: A scoping systematic review of published ultrasound ONSD …

The Importance Of Emphasizing Addiction Medicine During Medical Toxicology Fellowship Training: A Case Study Of Tertiary Care Hospital System Toxicology Consultation Service, Nicholas S. Imperato, Chase Jones Do, Derek J. Fikse Do, Gillian A. Beauchamp Md, Marna R. Greenberg Do, Mph, Facep, Alexandra Amaducci, Katelyn Mclain

Toxicology Division

No abstract provided.

On Behalf Of The Toxicology Investigators Consortium (Toxic). A Five-Year Analysis Of The Toxicology Investigator’S Consortium (Toxic) Core Registry: Exposure Differences In Patients That Identified As Transgender Vs. Cisgender, K Magnusson, Derek J. Fikse Do, E Glidden, Gillian A. Beauchamp Md, K Aldy, D Mustaquim, Judith Sabino Mph, Cdp, Marna R. Greenberg Do, Mph, Facep, Alexandra Amaducci

Toxicology Division

No abstract provided.

Genetic Structure Correlates With Ethnolinguistic Diversity In Eastern And Southern Africa, Elizabeth G. Atkinson, Shareefa Dalvie, Yakov Pichkar, Allan Kalungi, Lerato Majara, Anne Stevenson, Tamrat Abebe, Dickens Akena, Melkam Alemayehu, Lukoye Atwoli

Brain and Mind Institute

African populations are the most diverse in the world yet are sorely underrepresented in medical genetics research. Here, we examine the structure of African populations using genetic and comprehensive multi-generational ethnolinguistic data from the Neuropsychiatric Genetics of African Populations-Psychosis study (NeuroGAP-Psychosis) consisting of 900 individuals from Ethiopia, Kenya, South Africa, and Uganda. We find that self-reported language classifications meaningfully tag underlying genetic variation that would be missed with consideration of geography alone, highlighting the importance of culture in shaping genetic diversity. Leveraging our uniquely rich multi-generational ethnolinguistic metadata, we track language transmission through the pedigree, observing the disappearance of several …

Opioids Alter Paw Placement During Walking, Confounding Assessment Of Analgesic Efficacy In A Postsurgical Pain Model In Mice, Victoria E Brings, Maria A Payne, Robert W Gereau Iv

2020-Current year OA Pubs

Introduction: Hind paw-directed assays are commonly used to study the analgesic effects of opioids in mice. However, opioid-induced hyperlocomotion can obscure results of such assays.

Objectives: We aimed to overcome this potential confound by using gait analysis to observe hind paw usage during walking in mice.

Methods: We measured changes in the paw print area after induction of postsurgical pain (using the paw incision model) and treatment with oxycodone.

Results: Paw incision surgery reduced the paw print area of the injured hind paw as mice avoided placing the incised section of the paw on the floor. Surprisingly, oxycodone caused a …

Cerebral Venous Sinus Thrombosis Associated With Coronavirus Disease 2019: Case Report And Review Of The Literature, Kessarin Panichpisal, Ilana Ruff, Maharaj Singh, Massihullah Hamidi, Pedro D. Salinas, Kyle Swanson, Stephen Medlin, Sudeepta Dandapat, Payton Tepp, Genevieve Kuchinsky, Amy Pesch, Thomas Wolfe

College of Nursing Faculty Research and Publications

Introduction:

Coronavirus disease 2019 (COVID-19) is associated with significant risk of acute thrombosis. We present a case report of a patient with cerebral venous sinus thrombosis (CVST) associated with COVID-19 and performed a literature review of CVST associated with COVID-19 cases.

Case Report:

A 38-year-old woman was admitted with severe headache and acute altered mental status a week after confirmed diagnosis of COVID-19. Magnetic resonance imaging brain showed diffuse venous sinus thrombosis involving the superficial and deep veins, and diffuse edema of bilateral thalami, basal ganglia and hippocampi because of venous infarction. Her neurological exam improved with anticoagulation (AC) and …

A Qualitative Descriptive Study On Re-Assessing The Mental Certification By Faa For Future Pilots, Kaung Z. Min

Student Works

Mental illness becomes one of the main problems that most pilots do not usually address. It is not because pilots do not have the courage or are open enough to talk with someone, but because the Federal Aviation Administration (FAA) forces them to hide from mental depression. Most of the time, the pilots are not willing to declare such illnesses as they fear losing their job; simultaneously, the Federal Aviation Agencies across the world require pilots to be in peat health, including their mental condition, to operate the aircraft. While it can be said that the passengers’ and crews’ safety …

Risk Factors For Shoulder Disorders Among French Workers: Prospective Cohort Study, Julie Bodin, Ronan Garlantézec, Alexis Descatha, Bradley Evanoff, Thierry Thomas, Yves Roquelaure

2020-Current year OA Pubs

OBJECTIVES: Shoulder disorders are common in the working population. This longitudinal study aimed to explore the relationships between personal factors and occupational organisational, psychosocial, and biomechanical factors and the incidence of shoulder disorders.

METHODS: A total of 3710 workers in the Pays de la Loire region (Loire Valley area, France) were randomly included by their occupational physician in the Cosali cohort between 2002 and 2005. All workers completed a self-administered questionnaire about personal factors and work exposure, and using a standardised physical examination, occupational physicians diagnosed shoulder disorders. Between 2007 and 2010, 1611 workers were re-examined by their occupational physician. …

Cholecystitis Secondary To Salmonella Typhi: A Rare Pathology With An Unreported Management Option—A Case Report And Literature Review, Michael Ghio, Angelle Billiot, Jessica A. Zagory, Mary L. Brandt

School of Medicine Faculty Publications

Background: This report describes the presentation and course of treatment for one of the youngest reported cases of empyema of the gallbladder. Given the rare occurrence of this disease process, we elected to proceed with a systematic review of the literature. This is only the 7th case series discussing pediatric empyema of the gallbladder due to Salmonella typhi in the literature, and the second case ever reported in the USA. Case presentation: We report a case of a previously healthy 13-month-old girl who presented with diffuse peritonitis and equivocal imaging studies. Diagnostic laparoscopy revealed purulent peritonitis. The gallbladder was distended …

Himmelfarb Library Liaison Letter - September 2022, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Genitourinary And Sexual Symptoms And Treatments In Transfeminine Individuals: A Qualitative Exploration Of Patients' Needs, Paul Chung, Vishal Swaminathan, Sabina Spigner, Joon Yau Leong, Jessica Bulafka, Rosemary Frasso

Department of Urology Faculty Papers

Introduction: Medical providers may not be familiar with the genitourinary and sexual symptoms of transgender and non-binary (TGNB) individuals. This lack of familiarity may hinder a provider's ability to address these issues as patients may hesitate to report symptoms due to fear of stigma, misgendering, and being treated disrespectfully.

Aim: To describe the array of genitourinary and sexual symptoms in transfeminine individuals.

Methods: Upon institutional review board approval, researchers used semi-structured interviews with 25 transfeminine individuals assigned male at birth to explore urinary and sexual symptoms on a sample of convenience. Participants were recruited and interviews were conducted until saturation …

Addressing Immunizations In Nursing Education: Immunization Resources For Undergraduate Nursing, Sheryl Buckner, Ruth Gallego, Diana Mcnaughton, Susan Brasher, Joan Stanley, Allison Jacobs, Jennifer Hamborsky, Sarah Schillie, Stacie Hunsaker, Kathy J. Kyler, Allison L. Lewis, Donna Page

Faculty Publications

Nursing faculty are challenged to integrate immunization content in prelicensure nursing curricula. Historically, most immunization content has been delivered in pediatrics courses, with less emphasis on other populations across the lifespan. Skills related to vaccine administration may be prioritized over the most current immunization science, such as pathophysiology, immunology, and epidemiology. As the most trusted profession rated by the public (Saad, 2020), nurses are ideally suited to address vaccine hesitancy and promote vaccination in the communities they serve. Nurses apply active listening, problem solving, and communication skills with patients and their families, contributing to a person's confidence in their decision …

Factors Affecting Hospital Readmission Rates Following An Acute Coronary Syndrome: A Systematic Review, Amineh Rashidi, Lisa Whitehead, Courtney Glass

Research outputs 2014 to 2021

Aim

To synthesise quantitative evidence on factors that impact hospital readmission rates following ACS with comorbidities.

Design

Systematic review and narrative synthesis.

Data Sources

A search of eight electronic databases, including Embase, Medline, PsycINFO, Web of Science, CINAHL, Cochrane Library, Scopus and the Joanna Briggs Institute (JBI).

Review Methods

The search strategy included keywords and MeSH terms to identify English language studies published between 2001 and 2020. The quality of included studies was assessed by two independent reviewers, using Joanna Briggs Institute (JBI) critical appraisal tools.

Results

Twenty-four articles were included in the review. All cause 30-day readmission rate was …

The Relationship Between Emergency Physicians’ Creative Thinking Preference And Their Risk Of Burnout: An Opportunity To Make A Difference, Naghma S. Khan

Creativity and Change Leadership Graduate Student Master's Projects

The FourSight theory contends that individuals exhibit a preference for the mental operations involved in creative problem solving. The four fundamental mindset preferences measured by FourSight are Clarifiers, Ideators, Developers and Implementers. Individuals can exhibit a peak preference for one, two, or three of these mindsets, or they can show an even distribution of energy across all four creative-thinking preferences. Robust and creative solutions to complex and recurrent problems are only possible if an individual or a team of individuals consciously move through the four stages of problem solving. Creative problem-solving can be taught. The ability to be creative at …

Anti-Nmda Receptor Encephalitis Presenting With Severe Episodic Hypertension: A Case Report, Tehreem Arshad, Musarrat Hussain, Abdul Wahab Yousafzai, Arsalan Ahmad

Pakistan Journal of Neurological Sciences (PJNS)

Anti-N-methyl-D-aspartate receptor (Anti-NMDAR) encephalitis is one of the most commonly emerging autoimmune encephalitis in children and young adults in recent years. Clinical manifestations range from prodromal symptoms to seizures, movement disorder, psychiatric manifestations, cognitive/speech impairment, and autonomic dysfunction. Our case presented with initial symptoms of severe episodic hypertension, sweating, agitation, and tachycardia. She received early care for pheochromocytoma and panic disorder in Qatar, but there was no relief. Three weeks later, she presented in our emergency room with seizures, cognitive/speech impairment, and orofacial dyskinesia. Electroencephalography (EEG) revealed right hemispheric delta activity and cerebrospinal fluid CSF anti-NMDA Receptor IgG was positive. …

Clinical Spectrum, Risk Factors And Electrophysiologic Aspect Of Radial Nerve Injury, Arfah Kanwal, Safia Bano, Ubaid Ullah, Ahsan Numan

Pakistan Journal of Neurological Sciences (PJNS)

ABSTRACT

Background and objective: Radial nerve is injured due to a variety of reasons. The objective of this study was to determine the clinical spectrum, risk factors and electrophysiologic aspect of radial nerve injury presenting to a tertiary care hospital in Lahore.

Methods: This descriptive prospective cross-sectional study was conducted at department of Neurology, Mayo hospital Lahore from July 2022 to December 2022 and comprised patients with isolated radial nerve injury on the basis of history and clinical examination regardless of their gender, above 15 years of age. NCS/EMG was done on a Japanese machine Nihon Kohden by an expert …

Maxillary Central Incisor Rr In Hispanic And Non-Hispanic White Patients With Rme, Madison Healy

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: Apical root resorption is one of the most common adverse effects of orthodontic treatment. Forces used during orthodontic tooth movement can cause permanent loss of apical surfaces of teeth and although most reported cases of root resorption are asymptomatic, the process is irreversible and often unpredictable. Thus, it is of clinical interest to investigate which patients may be at greatest risk.

Purpose: This study utilized Cone Beam Computed Tomography (CBCT) to evaluate whether rapid maxillary expansion (RME) in Hispanic patients increased the severity of orthodontically induced apical root resorption.

Materials and Methods: Pre-treatment (T1) and post-treatment …

Mental Health In Coptic Orthodox Communities: Needs Assessment, Marina Zaky

Loma Linda University Electronic Theses, Dissertations & Projects

In order to better understand the contributing factors to low visibility and an overall lack of representation of Coptic Orthodox individuals within the field of mental health, a needs assessment was conducted. Previous research studies have focused on the low visibility of the Coptic Orthodox population within the field of mental health but have focused primarily on stigma, without determining other needs and contributing factors. This needs assessment utilized the Delphi method of data collection in order to conceptualize the needs of the community from the perspectives of experts within the group. An extensive literature review was completed in order …

Biology Through The Lens Of Trauma: An Empirical Review Of Trauma Treatments, Adela Gharabeki

Loma Linda University Electronic Theses, Dissertations & Projects

The present literature review aims at mending the research to practice gap for the treatment of Post-Traumatic Stress Disorder (PTSD). Biological mechanisms of the stress response system are explored as they pertain to trauma and its subsequent effects on the brain and body. In addition, American Psychological Association (APA) recommended evidence-based treatments for PTSD are reviewed as well as more recent emerging somatic therapies. There is a critical need for further development in the area of both topdown and bottom-up interventions. Biological working mechanisms remain unknown for a majority of treatments and physiological measures are scarcely used in treatment outcome …