Medicine and Health Sciences Commons^™

Interpretable Machine Learning Models For Molecular Design Of Tyrosine Kinase Inhibitors Using Variational Autoencoders And Perturbation-Based Approach Of Chemical Space Exploration, Keerthi Krishnan, Ryan Kassab, Steve Agajanian, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

In the current study, we introduce an integrative machine learning strategy for the autonomous molecular design of protein kinase inhibitors using variational autoencoders and a novel cluster-based perturbation approach for exploration of the chemical latent space. The proposed strategy combines autoencoder-based embedding of small molecules with a cluster-based perturbation approach for efficient navigation of the latent space and a feature-based kinase inhibition likelihood classifier that guides optimization of the molecular properties and targeted molecular design. In the proposed generative approach, molecules sharing similar structures tend to cluster in the latent space, and interpolating between two molecules in the latent space …

Hemodynamic Variations In Cardiogenic Shock Phenotypes, Jason Katz

Journal of Shock and Hemodynamics

Patients with cardiogenic shock are not all the same. They present with a variety of hemodynamic profiles and other features that may allow us to create specific phenotypes. It is possible that phenotyping these patients at presentation may then help us to identify the optimal and earliest therapies that will improve outcomes and, at the same time, help us to overcome some of the heterogeneity currently undermining clinical trials.

The Road To Championship: An Example Of An Individual With Autism Spectrum Disorder, Halil Sarol, Rıfat Kerem Gürkan, Bülent Gürbüz

Baltic Journal of Health and Physical Activity

The aim of this research is to investigate the road to championship of an individual with Autism Spectrum Disorder (ASD) who began physical activity in childhood under parental influence and won medals in competition as an athlete. In this research, founded on the phenomenological pattern from qualitative research models, data were collected in a semi-structured interview. Face-to-face interviews were held with the family, coach and the research participant. The content analysis method was used. The individual with ASD began a physical activity program in a special education center in childhood under parental influence and psychiatric referral. The individual with ASD …

2022-09-23_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Medical School Watercooler Newsletter - September 23, 2022, Lindsey Lyle

Watercooler Newsletter

This is the September 23, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Singh appointed to BCRFA Medical Advisory Council
• USA Health earns rectal cancer program accreditation
• Radiation safety officer to retire from USA
• Medical students volunteer at GO Run skin screening
• USA awarded $1.15 million to study impact of nicotine exposure on prostate cancer
• USA Health appoints new chief of anesthesia services
• Register now: USA Health Game Day set for Oct. 20

Covid Experience, Jorge Gracia

Community Reflections

My personal experience about the pandemic has been for me a lesson of life from which I was able to learn many things.

The Covid Pandemic Primary Source Paper, Anonymous

Community Reflections

Class assignment for Western Civilization, Professor Marino.

The Covid pandemic was the first world crisis my generation has lived through and been a part of. Almost every aspect of daily life had changed during the height of the pandemic, and some of these changes will most likely remain forever.

Chronic Illness Education 2022: Reducing Modifiable Risk Factors For Cardiovascular Disease, David Asebiode, Francis Lauzier, Jonathan Lutchka, Megan Rasaiah, Min Yi Wu, Sanjana Rao

Patient Education Projects

No abstract provided.

Effectiveness And Safety Of Apixaban Vs Warfarin Among Venous Thromboembolism Patients At High-Risk Of Bleeding, Alexander T. Cohen, Janvi Sah, A. D. Dhamane, Theodore Lee, Lisa Rosenblatt, Patrick Hlavacek, Birol Emir, Allison V. Keshishian, Huseyin Yuce, Xuemei Luo

Publications and Research

This study evaluated effectiveness and safety of apixaban versus warfarin among venous thromboembolism patients at high-risk of bleeding (defined as having at least one of the following bleeding risk factors: ≥75 years; used antiplatelet, NSAIDs, or corticosteroids; had prior gastrointestinal bleeding or gastrointestinal-related conditions; late stage chronic kidney disease). Adult venous thromboembolism patients initiating apixaban or warfarin with ≥1 bleeding risk factor were identified from Medicare and four commercial claims databases in the United States. To balance characteristics between apixaban and warfarin patients, stabilized inverse probability treatment weighting was conducted. Cox proportional hazards models were used to estimate the risk …

Chronic Illness Education 2022: Heart Health: It Starts Now, Heba Osman, Alejandro Ponce Sepulveda, Doo Hee Kim, Enoch Kim, Lauren Larson, Sadie Knill, Shagane Kotcharian

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Increasing Awareness Of Cardiovascular Disease In Older Adult Women, Dhruvil Patel, Anthony Grayson, Joel Drazin, Matthew Kim, Mikaela Grudzien, Rachel Feldstein, Sara Kazyak

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Improving Dietary Habits Among Undergraduate Students To Combat Anxiety/Depression, Aditi Kappagantu, Adrienne-Denise Bilbao, Alexander Buendia, Anuj Kavi, Lana Zalt, Mark Gregory, Rachel Puentes

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Obesity Awareness In Adults, Tyler Mumm, Daniel Kim, Jacob Katzman, Liana De La Torre, Mariam Samir, Parker Marsh, Pragathi Pathanjeli

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Chronic Kidney Disease Prevention In Patients With Hypertension And Diabetes., Ruchi Mangal, Lara Zraik, Nicolas Baroni, Sara Ma, Tulsi Sadasivan, Wouter Ritsema

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Adult Obesity Intervention Within Detroit Community, Dhruvil Patel, Andrew Kirmse, Andrew Mizerowski, Bethani Dunlap, Jacob Sullivan, Nicole Naidoo, Shirley Elfishawy

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Increasing Wound Care Vigilance In Adult Diabetic Patients With Neuropathy, Gowri Chandrashekar, Allen Zhang, Daniel Domin, Karis Tutuska, Sarah Bassett, Varsha Kumar

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Reducing The Stigma Of Hiv In Southeast Michigan, Ruchi Mangal, Alex Rodriguez, David Greiver, Johan Harris, Kathy Lu, Minisha Kanakarajan

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Demystifying Disparities In Pediatric Asthma In Detroit, Teresa Alfauhernandez, Ahmed Elashmawy, Arielle Wenokur, Bashir Kaspo, Kaitlin Ziadeh, Kyla Kosidowski, Mohamed Al-Hassan

Patient Education Projects

No abstract provided.

Cancer As A Channelopathy—Appreciation Of Complimentary Pathways Provides A Different Perspective For Developing Treatments, Harry J. [email protected] Gould, Dennis Paul

School of Medicine Faculty Publications

Life depends upon the ability of cells to evaluate and adapt to a constantly changing environment and to maintain internal stability to allow essential biochemical reactions to occur. Ions and ion channels play a crucial role in this process and are essential for survival. Alterations in the expression of the transmembrane proteins responsible for maintaining ion balance that occur as a result of mutations in the genetic code or in response to iatrogenically induced changes in the extracellular environment is a characteristic feature of oncogenesis and identifies cancer as one of a constellation of diseases known as channelopathies. The classification …

College Of Health Professions News, Georgia Southern University

College of Health Professions: News & Publications (2012-2023)

• New Mental Health and Wellness Room Opens

Assessing The Effect Of Four Types Of Direct Mail Messages To Promote The Uptake Of Residential Lead Remediation Funds, H. Okatch, B. Nkala, J. Beltrami, E. Poy, D. Parmer, J. Nkala, F. Olawole

College of Population Health Faculty Papers

Objective

To examine the efficacy of direct mailing using four types of messaging on promoting the uptake of residential lead remediation (RLR) funds in Lancaster, PA, USA.

Study design

We designed a quasi-experiment to assess the effect of 4 RLR messages sent to households in Lancaster, PA by direct mail between September and December 2020: a brief flyer (F); a detailed brochure + the flyer (BF); a health infographic + the flyer (IF); and an application form + the flyer (AFF).

Methods

Mailers were sent to addresses in four census tracts; each census tract received a different message. Both English …

Sterile Setup Table In The Operating Room Is Not So Sterile, Farideh Najafi, Diana Fernández-Rodríguez, Javad Parvizi

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: One of the important factors for surgical site infection prevention is the implementation of an ultraclean operating room. This study was designed to evaluate back-table sterility during total joint arthroplasty.

METHODS: This prospective study includes 52 patients undergoing primary total joint arthroplasty between November 2021 and January 2022. A total of 4 swabs (2 air swabs and 2 table swabs) were obtained for each case, at the conclusion of surgery and prior to the takedown of drapes. One swab from each set was sent for culture, and the other was sent for next-generation sequencing (NGS) analysis.

RESULTS: Among 104 …

Predicting At-Risk Opioid Use Three Months After Ed Visit For Trauma: Results From The Aurora Study, Brittany E. Punches, Uwe Stolz, Caroline E. Freiermuth, Rachel M. Ancona, Samuel A. Mclean, Stacey L. House, Francesca L. Beaudoin, Xinming An, Jennifer S. Stevens, Donglin Zeng, Thomas C. Neylan, Gari D. Clifford, Tanja Jovanovic, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher Lewandowski, Paul I. Musey Jr., Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Michael C. Kurz, Nina T. Gentile, Meghan E. Mcgrath, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Erica Harris, Anna M. Chang, Claire Pearson, David A. Peak, Roland C. Merchant, Robert M. Domeier, Niels K. Rathlev, Brian J. O'Neil, Leon D. Sanchez, Steven E. Bruce, Robert H. Pietrzak, Jutta Joormann, Deanna M. Barch, Diego A. Pizzagalli, Jordan W. Smoller, Beatriz Luna, Steven E. Harte, James M. Elliott, Ronald C. Kessler, Kerry J. Ressler, Karestan C. Koenen, Michael S. Lyons

Department of Emergency Medicine Faculty Papers

OBJECTIVE: Whether short-term, low-potency opioid prescriptions for acute pain lead to future at-risk opioid use remains controversial and inadequately characterized. Our objective was to measure the association between emergency department (ED) opioid analgesic exposure after a physical, trauma-related event and subsequent opioid use. We hypothesized ED opioid analgesic exposure is associated with subsequent at-risk opioid use.

METHODS: Participants were enrolled in AURORA, a prospective cohort study of adult patients in 29 U.S., urban EDs receiving care for a traumatic event. Exclusion criteria were hospital admission, persons reporting any non-medical opioid use (e.g., opioids without prescription or taking more than prescribed …

Irreversible Electroporation For Recurrent Pelvic Metastases: Case Series And Literature Review., Duncan A. Stevens, Jeffrey H. Savin, Brett J. Friedman, Michael A. Savin

Conference Presentation Abstracts

Purpose: Irreversible electroporation (IRE) is a nonthermal ablative technique that has potential safety advantages over thermal ablation in the treatment of tumors near critical structures. It creates an electrical field which forms permanent nanopores in the membranes of cells and triggers apoptosis. This case series reviews three patients with pelvic metastases from colorectal cancer treated with IRE.

Material and Methods: Two patients had rectal cancer and one sigmoid colon cancer. The mean age was 55 years and there were two males and one female. Thermal ablation was contraindicated due to proximity to ureter, bladder, bowel, and/or sciatic or lumbosacral nerves. …

Case Report: The Promising Application Of Dynamic Functional Connectivity Analysis On An Individual With Failed Back Surgery Syndrome, Jingya Miao, Isaiah Ailes, Laura Krisa, Kristen Fleming, Devon Middleton, Kiran Talekar, Peter Natale, Feroze B. Mohamed, Kevin Hines, Caio M. Matias, Mahdi Alizadeh

Department of Neurosurgery Faculty Papers

Failed back surgery syndrome (FBSS), a chronic neuropathic pain condition, is a common indication for spinal cord stimulation (SCS). However, the mechanisms of SCS, especially its effects on supraspinal/brain functional connectivity, are still not fully understood. Resting state functional magnetic resonance imaging (rsfMRI) studies have shown characteristics in patients with chronic low back pain (cLBP). In this case study, we performed rsfMRI scanning (3.0 T) on an FBSS patient, who presented with chronic low back and leg pain following her previous lumbar microdiscectomy and had undergone permanent SCS. Appropriate MRI safety measures were undertaken to scan this subject. Seed-based functional …

To Bind Or Not To Bind: Cistromic Reprogramming In Prostate Cancer, Michelle Shen, Léa-Kristine Demers, Swneke D Bailey, David P Labbé

Faculty, Staff and Student Publications

The term "cistrome" refers to the genome-wide location of regulatory elements associated with transcription factor binding-sites. The cistrome of key regulatory factors in prostate cancer etiology are substantially reprogrammed and altered during prostatic transformation and disease progression. For instance, the cistrome of the androgen receptor (AR), a ligand-inducible transcription factor central in normal prostate epithelium biology, is directly impacted and substantially reprogrammed during malignant transformation. Accumulating evidence demonstrates that additional transcription factors that are frequently mutated, or aberrantly expressed in prostate cancer, such as the pioneer transcription factors Forkhead Box A1 (FOXA1), the homeobox protein HOXB13, and the GATA binding …

Chronic Illness Education 2022: Addressing Common Causes Of Hypertension In The Detroit Adult Population, Kassandra Solrud, Crisshy Auguste, Kayvon Sanjasaz, Matthew Zabat, Rana Khamis, Soham Desai, Zeynoire Anderson

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Effects Of The Covid-19 Pandemic On Pediatric Mental Health And Actions We Can Take To Combat Them, Brandon Batarse, Giulia Santangelo, Katherine Heeres, Liam Browning, Nabta Laz, Simon Yacoub

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Preventing Or Managing Childhood Obesity Through Healthy Eating For Parents And Children, Kelsey Trulik, Brandon Hudson, Erin Markley, Nicole Ashley Hao, Nikhil Sundaram, Rommy Alaiwat

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Utilizing A Self-Care Journal To Improve Mental Health And Well-Being In Young Adults, Gowri Chandrashekar, Adam Elder, Melissa Ly, Mina Sitto, Vanessa Drust, Veronica Marougail, Zoe Jeffries

Patient Education Projects

No abstract provided.