Medicine and Health Sciences Commons^™

Risk Factors For Community-Acquired Bacterial Infection Among Young Infants In South Asia: A Longitudinal Cohort Study With Nested Case–Control Analysis, Nicholas E. Connor, Mohammad Shahidul Islam, Luke C. Mullany, Nong Shang, Zulfiqar Ahmed Bhutta, Anita K. M. Zaidi, Sajid Bashir Soofi, Muhammad Imran Nisar, Pinaki Panigrahi, Kalpana Panigrahi

Department of Paediatrics and Child Health

Objective: Risk factors predisposing infants to community-acquired bacterial infections during the first 2 months of life are poorly understood in South Asia. Identifying risk factors for infection could lead to improved preventive measures and antibiotic stewardship.
Methods: Five sites in Bangladesh, India and Pakistan enrolled mother-child pairs via population-based pregnancy surveillance by community health workers. Medical, sociodemographic and epidemiological risk factor data were collected. Young infants aged 0-59 days with signs of possible serious bacterial infection (pSBI) and age-matched controls provided blood and respiratory specimens that were analysed by blood culture and real-time PCR. These tests were used to build …

Measurement Of Sound Levels In A Neonatal Intensive Care Unit Of A Tertiary Care Hospital, Karachi, Pakistan, Saleema Khowaja, Shabina Ariff, Laila Ladak, Zainab Manan, Tazeen S. Ali

Department of Paediatrics and Child Health

Background: High sound levels in the neonatal intensive care unit (NICU) can alter preterm newborn hemodynamics and cause long-term neuro-developmental delays and hearing loss. The study aims to collate data on sound levels in a level IV NICU of a tertiary care hospital, identify the factors associated with them, and compare them with the international standards set by the World Health Organization (WHO), Environmental Protection Agency (EPA), and American Academy of Pediatrics (AAP).
Methods: We carried out a cross-sectional study in NICU from 8th April 2019 to 30th June 2019. Sound levels were recorded for 480 h, using a portable …

Funding Has No Effect On Clinical Outcomes Of Total Joint Arthroplasty Emerging Technologies: A Systematic Review Of Bibliometrics And Conflicts Of Interest, Garrhett G. Via, David A. Brueggeman, Joseph G. Lyons, Isabelle C. Ely, Andrew W. Froehle, Anil Krishnamurthy

School of Health and Exercise Sciences Faculty Publications

Background: The use of new total joint arthroplasty technologies, including patient-specific implants/instrumentation (PSI), computer-assisted (CA), and robotic-assisted (RA) techniques, is increasing. There is an ongoing debate regarding the value provided and potential concerns about conflicts of interest (COI).

Methods: PRISMA guidelines were followed. PubMed, MEDLINE, and Web of Science databases were searched for total hip and knee arthroplasties, unicompartmental knee arthroplasties (UKA), PSI, CA, and RA. Bibliometric data, financial COI, clinical/functional scores, and patient-reported outcomes were assessed.

Results: Eighty-seven studies were evaluated, with 35 (40.2%) including at least one author reporting COI, and 13 (14.9%) disclosing industry funding. COI and …

Motivational Components Involved In The Metamotivational Monitoring In Medical Students, Ali Norouzi, Dean Parmelee, Mohammad Shariati, Saiideh Norouzi, Maryam Alizadeh

Medical Education Faculty Publications

Background: Theoretical implications of self-regulated learning emphasize that self-regulation of motivation (metamotivation) plays an important role in learning, effort, perseverance, and academic success in general. Metamotivation is how people monitor and control their motivational states to achieve their goals. Researchers believe that metamotivation includes two reciprocal processes: metamotivational monitoring, evaluating whether the person has selected the proper level (quantity) and type (quality) of motivation to perform his tasks; and metamotivational control, using the results of the monitoring phase and applying suitable strategies for adapting or changing the motivation. In metamotivational monitoring, students try to identify the declined motivational component in …

An Appreciative Inquiry Of Community Based Disability Sports And Physical Activity Provision To Guide Future Development, Jennifer O Carroll Reidy

Theses

In 2008, the Irish Sports Inclusion Disability Programme (SIDP) was established to provide opportunities for people with disabilities to participate in a variety of sports and physical activity. Regular monitoring has been sporadic and disparate (Sport Ireland, 2016). Using the four-stage method of Appreciative Inquiry (Cooperrider, 1987), a series of interviews was undertaken with providers of the SIDP. Fourteen Coordinators, SIDOs and sports development workers were interviewed about the strengths, impacts and future for the SIDP. Six participants of the programmes also took part in a focus group concerning their perspectives of the current state and future potential for the …

The Effect Of Covid- 19 Pandemic Process On Social Psychology And Nature-Based Therapeutic Activities, Aysun Yalvac, Esmahan Yalcin, Murad A. Kasalak

University of South Florida (USF) M3 Publishing

Today, many scientists have stated that the use of nature-based products and activities at certain rates together with the healing effect of modern medical techniques during the epidemic that affects the whole world has health-supporting benefits. Based on these views, people's consumption of products obtained from natural resources has increased and the interest in outdoor activities in nature has increased. Due to the positive effects of these activities on mental health, socialization and rehabilitation processes, over time, it became necessary to consider these activities within the scope of therapeutic recreation applied to groups with health restrictions such as the disabled, …

Possibilities Of Using Neuromarketing Tools In The Hospitality Industry, Serdar Bulbul

University of South Florida (USF) M3 Publishing

Usage of neurosciences in social sciences has emerged new perspectives and methods for marketing and tourism marketing. Neuro-marketing and Neuro-tourism are some of those concepts. In the hospitality industry, marketing is in a complex state because the decision-making processes of the guests are unpredictable. For this reason, hotel managements are unable to satisfy guest’s requests and demands with traditional methods. Therefore, Neuro-marketing has importance because this new way of marketing has a high chance to replace currently used methods. Usage of Neuro-marketing in the hospitality industry could satisfy the guest requests while generating new marketing perspectives on hotel management. This …

Evaluation Of Wheat-Specific Peptide Targets For Use In The Development Of Elisa And Mass Spectrometry-Based Detection Methods, Jessica Humphrey

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Individuals with IgE-mediated wheat allergy and celiac disease must avoid the consumption of wheat. Those with celiac disease must also avoid rye and barley in addition to wheat as these make up the gluten-containing grains. To ensure products are accurately labeled, ELISA methods may be used to monitor compliance with food allergen and gluten-free regulations. Currently, available ELISA methods for wheat detection utilize monoclonal antibodies that target peptides from the gluten fraction of proteins, and therefore, also detect rye and barley. Limitations such as differing antibody reactivity and unequal gluten content among wheat, rye, and barley have led to inconsistent …

Examining The Effects Of Formal Education Level On The Montreal Cognitive Assessment, Renee S. White, Justin M. Barber, Jordan P. Harp, Gregory A. Jicha

Sanders-Brown Center on Aging Faculty Publications

Background: Brief, global assessments such as the Montreal Cognitive Assessment (MoCA) are widely used in primary care for assessing cognition in older adults. Like other neuropsychological instruments, lower formal education can influence MoCA interpretation.

Methods: Data from 2 large studies of cognitive aging were used—Alzheimer’s Disease Neuroimaging Initiative (ADNI) and National Alzheimer’s Coordinating Center (NACC). Both use comprehensive examinations to determine cognitive status and have brain amyloid status for many participants. Mixed models were used to account for random variation due to data source.

Results: Cognitively intact participants with lower education (≤12 years) were more likely than …

Multiple Gene Variants Linked To Alzheimer's-Type Clinical Dementia Via Gwas Are Also Associated With Non-Alzheimer's Neuropathologic Entities, Yuriko Katsumata, Lincoln M. P. Shade, Timothy J. Hohman, Julie A. Schneider, David A. Bennett, Jose M. Farfel, Walter A. Kukull, David W. Fardo, Peter T. Nelson

Sanders-Brown Center on Aging Faculty Publications

The classic pathologic hallmarks of Alzheimer’s disease (AD) are amyloid plaques and neurofibrillary tangles (AD neuropathologic changes, or ADNC). However, brains from individuals clinically diagnosed with “AD-type” (amnestic) dementia usually harbor heterogeneous neuropathologies in addition to, or other than, ADNC. We hypothesized that some AD-type dementia associated genetic single nucleotide variants (SNVs) identified from large genomewide association studies (GWAS) were associated with non-ADNC neuropathologies. To test this hypothesis, we analyzed data from multiple studies with available genotype and neuropathologic phenotype information. Clinical AD/dementia risk alleles of interest were derived from the very large GWAS by Bellenguez et al. (2022) who …

An Assessment Of Community Response To Life Threatening Bleeding, Amanda Swanberg

Honors Nursing Posters

Presented at the National Collegiate Honors Council (NCHC) Conference, November 4, 2022; Dallas, Texas.

Incidence Trends Of Kaposi Sarcoma Among Young Non-Hispanic Black Men By Us Regions, 2001-2018, Ryan Suk, Donna L White, Sheena Knights, Ank Nijhawan, Ashish A Deshmukh, Elizabeth Y Chiao

Center for Medical Ethics and Health Policy Staff Publications

Despite the overall national decline in Kaposi sarcoma (KS) incidence in the United States among persons living with HIV, previous studies suggest there might be specific subgroups of the US population that are associated with higher KS incidence rates than others. Using the 2001-2018 National Program of Cancer Registries and Surveillance, Epidemiology, and End Results Program database, we assessed KS incidence trends among young men aged 20-34 years by race and ethnicity and geographic region. Statistical significance is 2-sided. The KS incidence rate increased nationally by 1.5% per year in non-Hispanic Black men, whereas the rate decreased statistically significantly by …

A Rare Cause Of Urticaria In An Nsaid Tolerant Patient, Thao Le, Mary K. Mcleod, Laurianne Wild

Posters

Introduction: Acetaminophen is one of the most used anti-pyretics to mitigate fever. Few cases have been reported of hypersensitivity reactions to acetaminophen without non-steroidal anti-inflammatory drug (NSAID) intolerance. It is recommended that if there is suspected drug hypersensitivity then the patient should undergo an oral drug challenge. Case Description: A 49-year-old male presented for evaluation of urticaria that occurred with acetaminophen ingestion. He reported several episodes where he developed diffuse urticaria within 15 minutes of ingestion, but no other symptoms concerning for anaphylaxis. He was unsure of the dose. He also noted urticaria with Excedrin migraine, which contains acetaminophen, aspirin, …

Improving Fluid Management Of Extreme Premature Infants By Providing A Restrictive Fluid Management Algorithm In The Icn, Jacob S. Ward, Dena Hubbard, Nicholas Clark

Posters

Intro: Excessive fluid intake in extremely premature infants during the first week of life is known to increase risk of adverse events such as necrotizing enterocolitis (NEC), patent ductus arteriosus (PDA), and overall mortality. There also is some correlation with the need for mechanical ventilation and development bronchopulmonary dysplasia (BPD). While fluid restriction is recommended to decrease the likelihood of adverse outcomes, at our institution we found there was a wide variability in and lack of evidence-based standards on fluid management in this vulnerable population. We aimed to improve the fluid management of the extremely premature infants by standardizing a …

Professional Perspectives On Bilingualism In Persons With Autism Spectrum Disorder: A Pilot Study, Rosa N. Benavidez Saldivar, Jessica R. Stewart, Ruth Crutchfield, Roy K. Chen, Lily Puente

Communication Sciences & Disorders Faculty Publications

Purpose: The present study examined the perspectives of professionals regarding bilingualism and ASD.

Methods: A total of 27 professionals participated in this study. Data was collected via an online survey. The survey was designed based on a literature review and consultation with a team of experts in the field of ASD. Information relating to demographic information, professional practice information, and perspectives of bilingualism and ASD was collected.

Results: Professionals participating in the present study were most likely to agree with the statement, “A child with ASD from a bilingual household is able to understand both languages” and least likely …

Dentistry And The Law: Ex-Employees Who Solicit Patients Using Stolen Information, Dan Schulte Jd

The Journal of the Michigan Dental Association

This month’s Dentistry and the Law column discusses actions to take with a former employee who solicits patients. In cases where former employees solicit patients using stolen patient information, dental practices can take legal action. Employment agreements and employee handbooks should include confidentiality clauses. Breach of these clauses allows for lawsuits, seeking damages for business loss. Additional claims like tortious interference, unfair competition, and misappropriation may also apply. Michigan's Uniform Trade Secrets Act can provide injunctive relief and damages if the patient information is deemed a "trade secret." Seeking legal advice from an experienced attorney is essential.

Addressing A Labor Market Need For Health Managers And Policy Professionals: Development Of A Non-Clinical Health Science Degree Program For Health Policy And Management, Noemi Rodriguez

Publications and Research

Given the United States of America's health care’s rapidly shifting dynamics and demands to recalibrate its traditional operational and financial models particularly under the emergence of unprecedented strains to the healthcare system such as COVID-19, the Department of Health Sciences at the New York City College of Technology (NYCCT), City University of New York developed a four-year undergraduate degree program in healthcare policy and management. It utilizes a didactic and experiential curriculum to prepare students with very little or no healthcare experience to go into a robust and technology oriented labor market in healthcare planning, operations, and policy. The new …

How To Budget Better For Dental Supplies, Theodore C. Schumann Ii Mba, Msf, Cfp, Aif

The Journal of the Michigan Dental Association

Managing costs effectively is essential for dental practices in an era of rising inflation. One area where overspending can occur is clinical supplies. Over time, complacency among practice owners or staff in charge of ordering supplies can lead to repeated, uninformed purchases. Setting a budget and utilizing technology for supply-sourcing decisions can help control costs. Group purchasing organizations like The Dentists Supply Company (TDSC) can offer significant savings compared to traditional dental distributors. Additionally, practice owners need to strike a balance between bargain shopping for supplies and productive dentistry. Using inferior, cheaper products can lead to complications and costly rework, …

Getting Ahead: A Resident Led Quality Improvement Project To Increase Diabetic Nephropathy Screening In An Underserved Hispanic-Predominant Population, Stephanie Luu, Jose Rivera, Daniel Aragon, Victor Zamora-Legoff, Irma Huayanay, Reham Majzoub, Andreina Baird, Cristina Excobar Espinoza, Eric Sanchez, Juan C. Lopez-Alvarenga, Daniela Hernandez, Chelsea Chang

School of Medicine Publications

Introduction: Diabetes is the leading cause of end-stage renal disease (ESRD) in the United States (US), with 37 million having chronic kidney disease. Despite national guidelines recommendations for diabetic nephropathy screening with urine albumin-to-creatinine ratio (UACR), less than 50% receive full screening.

Our Internal Medicine residents led a quality improvement project to increase diabetic nephropathy screening rate with UACR in our resident clinic by 50% in one academic year.

Methods: We conducted the resident-led quality improvement project from July 2021 to April 2022. We reviewed the electronic medical records (EMR) from our clinic pre-intervention July 2020 to June 2021 …

Exploring Graduate Student Mental Health And Service Utilization By Gender, Race, And Year In School, Mikhila N. Wildey, Meghan E. Fox, Kelly A. Machnik, Deborah Ronk

Peer Reviewed Articles

Objective: The current study explored differences in mental health problems, services utilization, and support of graduate students by gender, race/ethnicity, and year in school.

Participants: Participants consisted of 734 graduate students from a large, Midwestern university.

Methods: Graduate students answered a series of questionnaires in fall 2021 assessing their mental health, services utilization, and perception of services.

Results: Women (vs men) and participants in their second year and beyond (vs first year) reported greater mental health problems, negative impact of the pandemic, and more services utilization. White (vs non-White) participants reported greater negative impact of the pandemic, greater services utilization, …

Chronic Kidney Disease Patients' Experiences In The Decision Making Process: The Relationship Between Personal Characteristics And Decisional Self-Efficacy On Decisional Conflict And The Dialysis Decision In Patients Who Participated In Shared Decision Making, Lincy Jojan

Theses & Dissertations

Patients with End Stage Renal Disease (ESRD) experience a complex and stressful decision making when comes to dialysis modality selection. There are pros and cons to both hemodialysis (HD) and peritoneal dialysis (PD). Patients are often uncertain as to which one is the best modality for them. This decisional conflict increases the likelihood of making a decision that is not based on the patient’s values or preferences and may result in undesirable post-decisional consequences. Purpose The purpose of this study was to explore Chronic Kidney Diseases (CKD) patients' experiences regarding their decision making process in selecting a dialysis modality. The …

Monitoring Quality Of Care In Hepatocellular Carcinoma: A Modified Delphi Consensus, Ashika D. Maharaj, John Lubel, Eileen Lam, Paul J. Clark, Oliver Duncan, Jacob George, Gary P. Jeffrey, Lara Lipton, Howard Liu, Geoffrey Mccaughan, Eu-Ling Neo, Jennifer Philip, Simone I. Strasser, Katherine Stuart, Alexander Thompson, Jonathan Tibballs, Thomas Tu, Michael C. Wallace, Alan Wigg, Marnie Wood, Amany Zekry, Elysia Greenhill, Liane J. Ioannou, Golo Ahlenstiel, Kaye Bowers, Stephen J. Clarke, Anouk Dev, Michael Fink, Mark Goodwin, Christos S. Karapetis, Miriam T. Levy, Kate Muller, James O'Beirne, David Pryor, James Seow, Nicholas Shackel, Caroline Tallis, Nick Butler, John K. Olynyk, Kate Reed-Cox, John R. Zalcberg, Stuart K. Roberts

Research outputs 2022 to 2026

Although there are several established international guidelines on the management of hepatocellular carcinoma (HCC), there is limited information detailing specific indicators of good quality care. The aim of this study was to develop a core set of quality indicators (QIs) to underpin the management of HCC. We undertook a modified, two-round, Delphi consensus study comprising a working group and experts involved in the management of HCC as well as consumer representatives. QIs were derived from an extensive review of the literature. The role of the participants was to identify the most important and measurable QIs for inclusion in an HCC …

Resistant Starch As A Dietary Intervention To Limit The Progression Of Diabetic Kidney Disease, Anna M. Drake, Melinda T. Coughlan, Claus T. Christophersen, Matthew Snelson

Research outputs 2022 to 2026

Diabetes is the leading cause of kidney disease, and as the number of individuals with diabetes increases there is a concomitant increase in the prevalence of diabetic kidney disease (DKD). Diabetes contributes to the development of DKD through a number of pathways, including inflammation, oxidative stress, and the gut-kidney axis, which may be amenable to dietary therapy. Resistant starch (RS) is a dietary fibre that alters the gut microbial consortium, leading to an increase in the microbial production of short chain fatty acids. Evidence from animal and human studies indicate that short chain fatty acids are able to attenuate inflammatory …

The Effects Of Acute High-Intensity Interval Exercise And Hyperinsulinemic-Euglycemic Clamp On Osteoglycin Levels In Young And Middle-Aged Men, Carlie Bauer, Alexander Tacey, Andrew Garnham, Cassandra Smith, Mary N. Woessner, Xuzhu Lin, Navabeh Zarekookandeh, David L. Hare, Joshua R. Lewis, Lewan Parker, Itamar Levinger

Research outputs 2022 to 2026

Osteoglycin (OGN) is a leucine-rich proteoglycan that has been implicated in the regulation of glucose in animal models. However, its relationship with glucose control in humans is unclear. We examined the effect of high-intensity interval exercise (HIIE) and hyperinsulinemic-euglycemic clamp on circulating levels of OGN as well as whether circulating OGN levels are associated with markers of glycemic control and cardio-metabolic health. Serum was analyzed for OGN (ELISA) levels from 9 middle-aged obese men (58.1 ± 2.2 years, body mass index [BMI] = 33.1 ± 1.4 kg∙m ^{− 2}, mean ± SEM) and 9 young men (27.8 ± 1.6 …

Social Ecological Influences On Treatment Decision-Making In Men Diagnosed With Low Risk, Localised Prostate Cancer, Megan Mcintosh, Melissa J. Opozda, Camille E. Short, Daniel A. Galvão, Rebecca Tutino, Michael Diefenbach, Behfar Ehdaie, Christian Nelson

Research outputs 2022 to 2026

Objective: Individuals diagnosed with low risk, localised prostate cancer (PCa) face a difficult decision between active surveillance (AS) and definitive treatment. We aimed to explore perceived influences on treatment decision-making from the patient and partner's perspectives. Methods: Patients (and partners) who met AS criteria and had chosen their treatment were recruited. Semi-structured individual interviews were conducted via telephone to explore experiences of diagnosis, impact on patient lifestyle, experiences with physicians, treatment preferences/choice, treatment information understanding and needs, and overall decision-making process. Interviews were audio recorded, transcribed verbatim, and analysed using Reflexive Thematic Analysis. Results: Twenty-four male patients (18 chose AS) …

Force Plate-Derived Countermovement Jump Normative Data And Benchmarks For Professional Rugby League Players, John J. Mcmahon, Nicholas J. Ripley, Paul Comfort

Research outputs 2022 to 2026

The countermovement jump (CMJ) is an important test in rugby league (RL), and the force plate is the recommended assessment device, as it permits the calculation of several variables that explain jump strategy, alongside jump height. The purpose of this study was to produce normative CMJ data and objective benchmarks for professional RL forwards and backs. Normative data for jump height, modified reactive strength index, and jump momentum are provided for 121 professional RL players (66 forwards and 55 backs) who completed CMJ testing on a portable force plate during preseason training. Standardized T-scores (scaled from 0 to 100) were …

On-Field Deployment And Validation For Wearable Devices, Calvin Kuo, Declan Patton, Tyler Rooks, Gregory Tierney, Andrew Mcintosh, Robert Lynall, Amanda Esquivel, Ray Daniel, Thomas Kaminski, Jason Mihalik, Nate Dau, Jillian Urban

Research outputs 2022 to 2026

Wearable sensors are an important tool in the study of head acceleration events and head impact injuries in sporting and military activities. Recent advances in sensor technology have improved our understanding of head kinematics during on-field activities; however, proper utilization and interpretation of data from wearable devices requires careful implementation of best practices. The objective of this paper is to summarize minimum requirements and best practices for on-field deployment of wearable devices for the measurement of head acceleration events in vivo to ensure data evaluated are representative of real events and limitations are accurately defined. Best practices covered in this …

Mitochondrial Dysfunction And Pharmacodynamics Of Mitofusin Activation In Murine Charcot-Marie-Tooth Disease Type 2a, Antonietta Franco, Xiawei Dang, Lihong Zhang, Perry B Molinoff, Gerald W Dorn 2nd

2020-Current year OA Pubs

Mitofusin (MFN) 1 and MFN2 are dynamin GTPase family mitochondrial proteins that mediate mitochondrial fusion requiring MFN conformational shifts, formation of macromolecular complexes on and between mitochondria, and GTP hydrolysis. Damaging MFN2 mutations cause an untreatable, largely pediatric progressive peripheral neuropathy, Charcot-Marie-Tooth (CMT) disease type 2A. We used small molecule allosteric mitofusin activators that promote MFN conformations favoring fusion to interrogate the effects of MFN2 conformation and GTPase activity on MFN2-mediated mitochondrial fusion and motility in vitro. We translated these findings in vivo by defining dose-dependent pharmacodynamic and disease-modifying effects of mitofusin activators in murine CMT2A. MFN2 catalytic GTPase activity …

Adjuvant Pembrolizumab Versus Placebo In Resected High-Risk Stage Ii Melanoma: Health-Related Quality Of Life From The Randomized Phase 3 Keynote-716 Study, Muhammad A. Khattak, Jason J. Luke, Georgina V. Long, Paolo A. Ascierto, Piotr Rutkowski, Dirk Schadendorf, Caroline Robert, Jean-Jacques Grob, Luis De La Cruz Merino, Michele Del Vecchio, Francesco Spagnolo, Jacek Mackiewicz, Vanna Chiarion-Sileni, Matteo S. Carlino, Peter Mohr, Federica De Galitiis, Merrick I. Ross, Zeynep Eroglu, Ke Chen, Ruixuan Jiang, Mizuho Fukunaga-Kalabis, Clemens Krepler, Alexander M. M. Eggermont, John M. Kirkwood

Research outputs 2022 to 2026

Background: Adjuvant pembrolizumab significantly improved recurrence-free survival (RFS) versus placebo in resected stage IIB and IIC melanoma in the phase 3 KEYNOTE-716 study. Health-related quality of life (HRQoL) results are reported. Methods: Patients were randomly assigned 1:1 to pembrolizumab 200 mg (2 mg/kg, patients ≥ 12 to < 18 years) Q3W or placebo for ≤ 17 cycles or until disease recurrence, unacceptable toxicity, or withdrawal. Change from baseline in EORTC QLQ-C30 global health status (GHS)/quality of life (QoL) was a prespecified exploratory end point. Change in EORTC QLQ-C30 functioning, symptom, and single-item scales, and EQ-5D-5L visual analog scale (VAS) were also summarized. Primary analyses were performed at week 48 to ensure adequate completion/compliance. The HRQoL population comprised patients who received ≥ 1 dose of treatment and completed ≥ 1 assessment. Results: The HRQoL population included 969 patients (pembrolizumab, n = 483; placebo, n = 486). Compliance at week 48 was ≥ 80 % for both instruments. EORTC QLQ-C30 GHS/QoL, physical functioning, role functioning, and EQ-5D-5L VAS scores were stable from baseline to week 48 in both arms, with no clinically meaningful decline observed. Scores did not differ significantly between pembrolizumab and placebo. EORTC QLQ-C30 GHS/QoL, physical functioning, role functioning, and EQ-5D-5L VAS scores remained stable through week 96 in both arms. Conclusions: HRQoL was stable with adjuvant pembrolizumab, with no clinically meaningful decline observed. Change from baseline in HRQoL was similar between arms. These results, in conjunction with the improved RFS and manageable safety previously reported, support the use of adjuvant pembrolizumab for high-risk stage II melanoma.

Assessing The Knowledge And Practices Of Occupational Safety And Health In The Artisanal And Small-Scale Gold Mining Sector Of Ghana: A Case Of Obuasi, Ebenezer Kwadwo Siabi, Peter Donkor, Samuel Kofi Mensah, Richmond Kotei Dzane, Napoleon Kurantin, Kwasi Frimpong, Sarah Elikplim Siabi, Christopher Vuu, Eddie Van Etten

Research outputs 2022 to 2026

It is noted that most developing countries such as Ghana are still grappling with health and safety policies and practices as governments and corporations have made insignificant efforts. This study utilized a questionnaire since it is suitable for both illiterate and literate respondents and allows for the gathering of massive quantities of data in a short space of time. The descriptive statistics, chi-square, likelihood ratio test regression, and correlation were used to assess the occupational safety and health knowledge and practices of employees in the artisanal small-scale gold mine in Obuasi. Although majority of the respondents had less than 5 …