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Articles 23281 - 23310 of 23775
Full-Text Articles in Medicine and Health Sciences
Proximal Femoral Nail Antirotation Versus Cemented Calcar-Replacement Hemiarthroplastyfor Unstable Intertrochanteric Fracture In Elderly: An Overall Survival Study, Fati̇h Durgut, Erdem Şahi̇n, Sadetti̇n Çi̇ftci̇, Bahatti̇n Kerem Aydin
Proximal Femoral Nail Antirotation Versus Cemented Calcar-Replacement Hemiarthroplastyfor Unstable Intertrochanteric Fracture In Elderly: An Overall Survival Study, Fati̇h Durgut, Erdem Şahi̇n, Sadetti̇n Çi̇ftci̇, Bahatti̇n Kerem Aydin
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to compare the perioperative complications and overall survival of patients who underwent proximal femoral nail antirotation (PFNA) and patients who underwent cemented calcar-replacement hemiarthroplasty (CCRH) for unstable intertrochanteric fracture in patients aged 75 years and older. Materials and methods: A total of 94 patients who underwent PFNA or CCRH between 2010 and 2012 because of femur fracture (A2.2 and A2.3 according to the Arbeitsgemeinschaft für Osteosynthesefragen/Orthopaedic Trauma Association (AO/OTA) classification) were analyzed retrospectively. Hospitalization times, blood transfusion needs, reoperation rates, and overall survival were compared. Results: Forty-eight patients in the PFNA group and …
Pasireotide Treatment In Cushing's Disease: A Single Tertiary Center's Experience, Serdar Şahi̇n, Gular Kari̇mova, Şeyda Gül Özcan, Emre Durcan, Hande Mefkure Özkaya, Pinar Kadioğlu
Pasireotide Treatment In Cushing's Disease: A Single Tertiary Center's Experience, Serdar Şahi̇n, Gular Kari̇mova, Şeyda Gül Özcan, Emre Durcan, Hande Mefkure Özkaya, Pinar Kadioğlu
Turkish Journal of Medical Sciences
Background/aim: Cushing's disease (CD), which cannot be controlled by surgery, requires medical treatment. In this situation, treatments with long-term effectiveness and safety profiles are needed. We aimed to evaluate the effects and adverse effects of pasireotide treatment in CD. Materials and methods: Patients who were followed up for CD and treated with pasireotide between 2014-2020 at Cerrahpaşa Medical Faculty, were evaluated retrospectively. The efficacy and adverse effects of pasireotide were evaluated in this study. Results: Thirty-two patients were evaluated. The mean duration of treatment was 26.5 [range, 12.0-37.0] months. The 24-h urinary free cortisol (UFC) decreased 46% during the treatment …
Evaluation Of The Relationship Between Insulin Resistance And Visceral Adiposity Index Inpatients With Acne Vulgaris, İbrahi̇m Fuat Kayihan Kaya, M. Ali̇ Eryilmaz, Selma Pekgör, Orhan Külahci
Evaluation Of The Relationship Between Insulin Resistance And Visceral Adiposity Index Inpatients With Acne Vulgaris, İbrahi̇m Fuat Kayihan Kaya, M. Ali̇ Eryilmaz, Selma Pekgör, Orhan Külahci
Turkish Journal of Medical Sciences
Background/aim: Acne vulgaris (AV) is a chronic inflammatory skin disease that is common among adolescents. Its etiology involves hormones, diet, genetics, and environmental factors. The aim of this study was to investigate the association between acne vulgaris and insulin resistance (IR) and visceral adiposity index (VAI). Materials and methods: The study included 184 individuals. Participants' height, weight, waist and hip circumference and blood pressure were measured. Morning fasting blood was obtained from all participants for measuring glucose, insulin, triglyceride (TG), and cholesterol levels. The HOMA index and visceral adiposity index were calculated. The collected data were analyzed using statistical methods. …
The Effectiveness Of Anti-Interleukin-1 Therapy On Subclinical Inflammation Parametersduring The Attack-Free Period In Familial Mediterranean Fever Patients: A Case-Control Study, Ebru Atalar, İsmai̇l Doğan, Kevser Gök, Serdar Can Güven, Yüksel Maraş, Gülay Güleç Ceylan, Şükran Erten
The Effectiveness Of Anti-Interleukin-1 Therapy On Subclinical Inflammation Parametersduring The Attack-Free Period In Familial Mediterranean Fever Patients: A Case-Control Study, Ebru Atalar, İsmai̇l Doğan, Kevser Gök, Serdar Can Güven, Yüksel Maraş, Gülay Güleç Ceylan, Şükran Erten
Turkish Journal of Medical Sciences
Background/aim: Anti IL-1 therapy is useful in suppressing attacks in FMF patients with colchicine resistance, however, it is not certain whether subclinical inflammation can sufficiently be inhibited with anti-IL-1 therapy in FMF patients with amyloidosis. Materials and methods: Forty-six FMF patients receiving anti-interleukin-1 therapy and 36 healthy control patients were compared in terms of laboratory parameters. Also, FMF patients were further divided into two groups; those with amyloidosis and those without it, and these subgroups were compared to each other in terms of clinical and laboratory findings. Results: In comparison between the FMF and healthy control groups, erythrocyte sedimentation rate …
Irisin Relaxes Rat Thoracic Aorta Through Inhibiting Signaling Pathways Implicatingprotein Kinase C, Sadetti̇n Demi̇rel, Serdar Şahi̇ntürk, Naci̇ye İşbi̇l, Fadil Özyener
Irisin Relaxes Rat Thoracic Aorta Through Inhibiting Signaling Pathways Implicatingprotein Kinase C, Sadetti̇n Demi̇rel, Serdar Şahi̇ntürk, Naci̇ye İşbi̇l, Fadil Özyener
Turkish Journal of Medical Sciences
Background/aim: Irisin, a newly identified exercise-derived myokine, has been found involved in a peripheral vasodilator effect. However, little is known regarding the potential vascular activity of irisin, and the mechanisms underlying its effects on vascular smooth muscle have not been fully elucidated. This study was aimed to investigate the effects of irisin on vascular smooth muscle contractility in rat thoracic aorta, and the hypothesis that protein kinase C (PKC) may have a role in these effects. Materials and methods: Isometric contraction-relaxation responses of thoracic aorta rings were measured with an isolated organ bath model. The steady contraction was induced with …
Evaluation Of The Frequency And Intensity Of Covid-19 In Patients With Ankylosingspondylitis Under Anti-Tnf Therapy, Sümeyye Merve Türk, Zeynep Öztürk, Damla Karataş, Ünal Erkorkmaz, Emel Gönüllü
Evaluation Of The Frequency And Intensity Of Covid-19 In Patients With Ankylosingspondylitis Under Anti-Tnf Therapy, Sümeyye Merve Türk, Zeynep Öztürk, Damla Karataş, Ünal Erkorkmaz, Emel Gönüllü
Turkish Journal of Medical Sciences
No abstract provided.
The Role Of Leptin In Primary Sjögren Syndrome: A Clinical And Histopathologicalassessment Study, Mustafa Erdogan, Kayhan Basak, Mehmet Engin Tezcan
The Role Of Leptin In Primary Sjögren Syndrome: A Clinical And Histopathologicalassessment Study, Mustafa Erdogan, Kayhan Basak, Mehmet Engin Tezcan
Turkish Journal of Medical Sciences
No abstract provided.
Pertussis Prevalence Among Adult Patients With Acute Cough, Ahmet İlbay, Mi̇ne Durusu Tanriöver, Işkin Pinar Zarakol, Ezgi̇ Çalişkan Güzelce, Hati̇ce Bölek, Serhat Ünal
Pertussis Prevalence Among Adult Patients With Acute Cough, Ahmet İlbay, Mi̇ne Durusu Tanriöver, Işkin Pinar Zarakol, Ezgi̇ Çalişkan Güzelce, Hati̇ce Bölek, Serhat Ünal
Turkish Journal of Medical Sciences
Background/aim: Bordetella pertussis infection remains an important health problem in adults due to the increasing prevalence in recent years. Pertussis in adults can be easily overlooked or misdiagnosed. We aimed to determine the prevalence of pertussis in adult patients with acute cough and the clinical features of the pertussis cases. Materials and methods: Internal Medicine and Pulmonology inpatient wards and outpatient clinics were screened between March 2017 and June 2018. Patients with cough duration between 1 week and 1 month were enrolled. Those who were on antibiotics for more than 5 days were excluded. A total of 115 patients were …
The Validity And Reliability Study Of The Turkish Version Of Engagement In Healthy Ageing, Ramazan Kiraç, Seda Uyar, Mehmet Aki̇f Eri̇şen, Nur Feyzal Kesen
The Validity And Reliability Study Of The Turkish Version Of Engagement In Healthy Ageing, Ramazan Kiraç, Seda Uyar, Mehmet Aki̇f Eri̇şen, Nur Feyzal Kesen
Turkish Journal of Medical Sciences
No abstract provided.
The Relationship Between Elevated Plasma Zonulin Levels And Hashimoto's Thyroiditis, Esra Demi̇r, Burak Önal, Hani̇şe Özkan, İrem Kiraç Utku, Berrak Sahti̇yanci, Abdulbaki̇ Kumbasar, Guven Yenmis, Bülent Demi̇r
The Relationship Between Elevated Plasma Zonulin Levels And Hashimoto's Thyroiditis, Esra Demi̇r, Burak Önal, Hani̇şe Özkan, İrem Kiraç Utku, Berrak Sahti̇yanci, Abdulbaki̇ Kumbasar, Guven Yenmis, Bülent Demi̇r
Turkish Journal of Medical Sciences
No abstract provided.
Morphometric Analysis Of Hippocampus And Intracranial Formations Based On Their Stages In Patients Diagnosed With Major Cognitive Disorder, Nurullah Yücel, Muzaffer Şeker, Mehmet Tuğrul Yilmaz, Zaki̇r Sakci, Yaşar Bükte
Morphometric Analysis Of Hippocampus And Intracranial Formations Based On Their Stages In Patients Diagnosed With Major Cognitive Disorder, Nurullah Yücel, Muzaffer Şeker, Mehmet Tuğrul Yilmaz, Zaki̇r Sakci, Yaşar Bükte
Turkish Journal of Medical Sciences
No abstract provided.
Test-Retest Reliability And Minimal Detectable Change For Measures Of Wearable Gait Analysis System (G-Walk) In Children With Cerebral Palsy., Melek Volkan Yazici, Gamze Çobanoğlu, Gökhan Yazici
Test-Retest Reliability And Minimal Detectable Change For Measures Of Wearable Gait Analysis System (G-Walk) In Children With Cerebral Palsy., Melek Volkan Yazici, Gamze Çobanoğlu, Gökhan Yazici
Turkish Journal of Medical Sciences
No abstract provided.
Effectiveness Of A Supervised Group Exercise Therapy Based On The Biopsychosocial Model Introduced Simultaneously With Anti-Tnf Therapy In Anti-Tnf-Naive Patients With Active Ankylosing Spondylitis, Nur Banu Karaca, Edi̇be Ünal, Jale Karakaya, Umut Kalyoncu, Sedat Ki̇raz
Effectiveness Of A Supervised Group Exercise Therapy Based On The Biopsychosocial Model Introduced Simultaneously With Anti-Tnf Therapy In Anti-Tnf-Naive Patients With Active Ankylosing Spondylitis, Nur Banu Karaca, Edi̇be Ünal, Jale Karakaya, Umut Kalyoncu, Sedat Ki̇raz
Turkish Journal of Medical Sciences
No abstract provided.
Arthroscopic Bankart Repair Improves Upper Limb Exercise Capacity, Shoulder Function And Quality Of Life, Fi̇gen Dağ, Fehmi̇ Volkan Öztuna, Di̇dem Deri̇ci̇ Yildirim, Özlem Bölgen Çi̇men
Arthroscopic Bankart Repair Improves Upper Limb Exercise Capacity, Shoulder Function And Quality Of Life, Fi̇gen Dağ, Fehmi̇ Volkan Öztuna, Di̇dem Deri̇ci̇ Yildirim, Özlem Bölgen Çi̇men
Turkish Journal of Medical Sciences
No abstract provided.
Oncometabolites In Urine-A New Opportunity For Detection And Prognosis Of The Clinical Progress Of Verified Prostate Cancer-A Pilot Study, Dimitar Delkov, Lyubka Yoanidu, Desislav Tomov, Rumyana Stoyanova, Ivan Dechev, Yordanka Uzunova
Oncometabolites In Urine-A New Opportunity For Detection And Prognosis Of The Clinical Progress Of Verified Prostate Cancer-A Pilot Study, Dimitar Delkov, Lyubka Yoanidu, Desislav Tomov, Rumyana Stoyanova, Ivan Dechev, Yordanka Uzunova
Turkish Journal of Medical Sciences
No abstract provided.
Application Of High-Flow Oxygen Therapy In Acute Pancreatitis Complicated With Acute Respiratory Dysfunction, Xiang Ji, Jie Zhou, Wenting Wu, Yan Tang, Tongrong Xu
Application Of High-Flow Oxygen Therapy In Acute Pancreatitis Complicated With Acute Respiratory Dysfunction, Xiang Ji, Jie Zhou, Wenting Wu, Yan Tang, Tongrong Xu
Turkish Journal of Medical Sciences
No abstract provided.
Association Between Depression Scores And Comprehensive Geriatric Assessment And Frailty In Geriatric Outpatients With Somatic Complaints: An Observational Cross-Sectional Study, Hande Selvi̇ Öztorun, Bi̇lge Gözükara, Remzi̇ Bahşi̇, Tuğba Turgut, Deni̇z Mut Sürmeli̇, Çağlar Coşardereli̇oğlu Seçer, Volkan Atmiş, Ahmet Yalçin, Sevgi̇ Aras, Murat Varli
Association Between Depression Scores And Comprehensive Geriatric Assessment And Frailty In Geriatric Outpatients With Somatic Complaints: An Observational Cross-Sectional Study, Hande Selvi̇ Öztorun, Bi̇lge Gözükara, Remzi̇ Bahşi̇, Tuğba Turgut, Deni̇z Mut Sürmeli̇, Çağlar Coşardereli̇oğlu Seçer, Volkan Atmiş, Ahmet Yalçin, Sevgi̇ Aras, Murat Varli
Turkish Journal of Medical Sciences
No abstract provided.
Evaluation Of Anthropometric Measurements And Clinical Tests In The Diagnosis Of Difficult Airway In Patients Undergoing Head And Neck Surgery, Şükrü Mert Başpinar, İlkben Günüşen, Demet Sergi̇n, Asuman Sargin, Saci̇tti̇n Taner Balcioğlu
Evaluation Of Anthropometric Measurements And Clinical Tests In The Diagnosis Of Difficult Airway In Patients Undergoing Head And Neck Surgery, Şükrü Mert Başpinar, İlkben Günüşen, Demet Sergi̇n, Asuman Sargin, Saci̇tti̇n Taner Balcioğlu
Turkish Journal of Medical Sciences
No abstract provided.
Effects Of Iron Deficiency On Left Ventricular Functions In Young Women Regardless Of Anemia: A Speckle Tracking Echocardiography Study, Betül Cengi̇z Elçi̇oğlu, Onur Baydar, Alparslan Kiliç, Ni̇hal Tefik, Füsun Helvaci, Erol Gürsoy, Yasemi̇n Demi̇rci̇, Di̇lek Ural, Vedat Ayteki̇n, Sai̇de Ayteki̇n
Effects Of Iron Deficiency On Left Ventricular Functions In Young Women Regardless Of Anemia: A Speckle Tracking Echocardiography Study, Betül Cengi̇z Elçi̇oğlu, Onur Baydar, Alparslan Kiliç, Ni̇hal Tefik, Füsun Helvaci, Erol Gürsoy, Yasemi̇n Demi̇rci̇, Di̇lek Ural, Vedat Ayteki̇n, Sai̇de Ayteki̇n
Turkish Journal of Medical Sciences
No abstract provided.
Mortality Related Factors On Hypoxic Ischemic Encephalopathic Patients Treated With Therapeutic Hypothermia: A 11-Year Single Center Experience, Mehmet Fati̇h Deveci̇, Hati̇ce Turgut, Meral Alagöz, Hüseyi̇n Kaya, İsmai̇l Kürşad Gökçe, Ramazan Özdemi̇r
Mortality Related Factors On Hypoxic Ischemic Encephalopathic Patients Treated With Therapeutic Hypothermia: A 11-Year Single Center Experience, Mehmet Fati̇h Deveci̇, Hati̇ce Turgut, Meral Alagöz, Hüseyi̇n Kaya, İsmai̇l Kürşad Gökçe, Ramazan Özdemi̇r
Turkish Journal of Medical Sciences
No abstract provided.
Evaluation Of Organic Load Related Efficacy Changes In Antiseptic Solutions Used In Hospitals, Asli Şahi̇ner, Ece Halat, Evren Alğin Yapar, Bi̇lge Ahsen Kara
Evaluation Of Organic Load Related Efficacy Changes In Antiseptic Solutions Used In Hospitals, Asli Şahi̇ner, Ece Halat, Evren Alğin Yapar, Bi̇lge Ahsen Kara
Turkish Journal of Medical Sciences
No abstract provided.
Medically Important Candida Spp. Identification: An Era Beyond Traditional Methods, Ebru Evren, Juli̇de Sedef Göçmen, Elvan Hortaç İştar, Şükran Yavuzdemi̇r, Fazil Alper Tekeli̇, Yasemi̇n Yavuz, Zeynep Ceren Karahan
Medically Important Candida Spp. Identification: An Era Beyond Traditional Methods, Ebru Evren, Juli̇de Sedef Göçmen, Elvan Hortaç İştar, Şükran Yavuzdemi̇r, Fazil Alper Tekeli̇, Yasemi̇n Yavuz, Zeynep Ceren Karahan
Turkish Journal of Medical Sciences
No abstract provided.
Does Memantine Show Chemopreventive Effect Against Mice 4t1 Breast Tumor Model?, Gülşah Albayrak, Eli̇f Burcu Bali̇, Funda Demi̇rtaş Korkmaz, Emi̇n Ümi̇t Bağriaçik
Does Memantine Show Chemopreventive Effect Against Mice 4t1 Breast Tumor Model?, Gülşah Albayrak, Eli̇f Burcu Bali̇, Funda Demi̇rtaş Korkmaz, Emi̇n Ümi̇t Bağriaçik
Turkish Journal of Medical Sciences
No abstract provided.
Classical Heart Rate Variability And Non-Linear Heart Rate Analysis In Mice Under Na-Pentobarbital And Ketamine/Xylazine Anesthesia., Hasan Kazdağli, Hasan Fehmi̇ Özel, Mustafa Özbek, Şüheda Alpay, Mürüvvet Alenbey
Classical Heart Rate Variability And Non-Linear Heart Rate Analysis In Mice Under Na-Pentobarbital And Ketamine/Xylazine Anesthesia., Hasan Kazdağli, Hasan Fehmi̇ Özel, Mustafa Özbek, Şüheda Alpay, Mürüvvet Alenbey
Turkish Journal of Medical Sciences
No abstract provided.
Evidence-Based Information About Intermittent Fasting In Diabetes Patients: Useful Or Harmful?, Mustafa Altay
Evidence-Based Information About Intermittent Fasting In Diabetes Patients: Useful Or Harmful?, Mustafa Altay
Turkish Journal of Medical Sciences
Background/aim: One of the most important components of treatment for diabetic patients is diet and healthy nutrition therapy. Calorie restriction is effective and without cost increases its appeal for both patients and physicians. Unfortunately, continuous calorie restriction is a difficult method. For this reason, alternative calorie restriction methods, such as intermittent fasting (IF), have been investigated by some researchers. Materials and methods: IF refers to a wide range of diet programmes covering periods of eating and fasting, which vary according to the different regimens. In this article, first, some general information will enable us to understand the concept of IF, …
The Role Of Cd8+ Regulatory T Cells And B Cell Subsets In Patients With Covid-19, Hülya Uçaryilmaz, Di̇lek Ergün, Hüsametti̇n Vatansev, Hande Köksal, Onur Ural, Uğur Arslan, Hasi̇be Artaç
The Role Of Cd8+ Regulatory T Cells And B Cell Subsets In Patients With Covid-19, Hülya Uçaryilmaz, Di̇lek Ergün, Hüsametti̇n Vatansev, Hande Köksal, Onur Ural, Uğur Arslan, Hasi̇be Artaç
Turkish Journal of Medical Sciences
Background/aim: Coronavirus disease 2019 (COVID-19) has a wide clinical spectrum from asymptomatic to mild, moderate, and severe cases. There are still many unknowns about the role of immunoregulatory mechanisms in COVID-19. We aimed to study regulatory T cells (Tregs) and B cell subsets and evaluate their correlations with severity of COVID-19. Materials and methods: In total, 50 patients with COVID-19 confirmed by PCR (mean age = 49.9 ± 12.8 years) and 40 healthy control (mean age = 47.9 ± 14.7 years) were included in this study. The patients were classified as 14 mild (median age = 35.5 [24-73] years), 22 …
Covid-19 Course In Granulomatosis With Polyangiitis: Single Center Experience With Review Of The Literature, Berkan Armağan, Mehmet Aki̇f Eksi̇n, Serdar Can Güven, Bahar Özdemi̇r, Pinar Akyüz Dağli, Orhan Küçükşahi̇n, Ahmet Omma, Abdulsamet Erden
Covid-19 Course In Granulomatosis With Polyangiitis: Single Center Experience With Review Of The Literature, Berkan Armağan, Mehmet Aki̇f Eksi̇n, Serdar Can Güven, Bahar Özdemi̇r, Pinar Akyüz Dağli, Orhan Küçükşahi̇n, Ahmet Omma, Abdulsamet Erden
Turkish Journal of Medical Sciences
Background/aim: Coronavirus disease 2019 (COVID-19) shares some clinical features with new-onset granulomatosis with polyangiitis (GPA) or GPA flare that may lead to a challenge in differential diagnosis. To date, little is known whether GPA can be induced by COVID-19. Herein, we aimed to seek the frequency and mortality rates of COVID-19 in our GPA cohort, and along with the literature cases, to evaluate clinical features and treatments of GPA patients with COVID-19. We also tried to identify clinical features of COVID-19 induced GPA. Materials and methods: As of July 2021, we conducted a systematic literature review using different spelling combinations …
Determination Of Cardiovascular Risk In 192,711 Underweight And Normal Weight Workers, Bárbara Altisench Jané, José Ignacio Ramírez Manent, Sebastiana Arroyo Bote, Pere Riutord Sbert, Hilda María González San Miguel, Angel Arturo Lopez Gonzalez
Determination Of Cardiovascular Risk In 192,711 Underweight And Normal Weight Workers, Bárbara Altisench Jané, José Ignacio Ramírez Manent, Sebastiana Arroyo Bote, Pere Riutord Sbert, Hilda María González San Miguel, Angel Arturo Lopez Gonzalez
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine the prevalence of cardiovascular risk factors (CVRF) and the level of cardiovascular risk (CVR), determined with different scales (REGICOR, SCORE, ERICE, vascular age...) in people with low and normal weight. Materials and Methods: A total of 192,711 underweight and normal weight Spanish workers participated. CVR parameters included were weight, abdominal circumference, blood pressure, glycemia (high >125 mg/dL or under hypoglycemic treatment) and lipids (cutoff points: total cholesterol 200 mg/dL, LDL 130 mg/dL, triglycerides 150 mg/dL) were obtained by automated enzymatic methods. Body mass index (BMI) was calculated, considering underweight 18.5 and …
Comparison Of Intraoperative Biliary Anastomosis Stenting Technique In Living-Donor Liver Transplantation: Review Of 41 Patients, Ramazan Dönmez, Şener Balas, Ufuk Utku Göktuğ, Ertan Emek, Yaman Tokat
Comparison Of Intraoperative Biliary Anastomosis Stenting Technique In Living-Donor Liver Transplantation: Review Of 41 Patients, Ramazan Dönmez, Şener Balas, Ufuk Utku Göktuğ, Ertan Emek, Yaman Tokat
Turkish Journal of Medical Sciences
Background/aim: Biliary fistula is one of the most important complications in liver transplantation. Complications can vary from simple local peritonitis to death, and various techniques have been described to prevent them. In this study, we compared two different stenting methods used in biliary tract anastomosis in living-donor liver transplantation. Material and methods: We retrospectively analyzed data from 41 living-donor liver transplantations that were performed due to endstage liver failure between August 2019 and November 2020. Patients were grouped according to the stenting technique used in biliary anastomosis. Postoperative biliary tract complications were investigated. Results: Biliary fistulas were observed in 2 …
The Role Of Vitamin D-Synthesizing Enzyme Cyp27b1 In Systemic Lupus Erythematosus, Man Luo, Jing Liu, Yeshuang Yuan, Yong Chen, Guohua Yuan
The Role Of Vitamin D-Synthesizing Enzyme Cyp27b1 In Systemic Lupus Erythematosus, Man Luo, Jing Liu, Yeshuang Yuan, Yong Chen, Guohua Yuan
Turkish Journal of Medical Sciences
Background/aim: To measure the expression of 1α-hydroxylase (CYP27B1) and serum 25(OH)D concentration in systemic lupus erythematosus (SLE) and to investigate the role of CYP27B1 in SLE. Materials and methods: Seventy-seven SLE patients and 35 healthy controls (HCs) were enrolled from September 2017 to January 2020. T he study design is cross-sectional. mRNA expression of CYP27B1 in peripheral blood mononuclear cells (PBMCs) was measured by reverse-transcription quantitative PCR, the protein level of CYP27B1 was quantified by western blotting, and the serum level of 25(OH) D was determined by an enzyme-linked immunosorbent assay. Results: The mRNA expression of CYP27B1 in PBMCs was …