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2022

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Articles 23251 - 23280 of 23775

Full-Text Articles in Medicine and Health Sciences

It Is Time To Define An Organizational Model For The Prevention And Management Of Infections Along The Surgical Pathway: A Worldwide Cross-Sectional Survey, Massimo Sartellli, John E. Mazuski, Et Al. Jan 2022

It Is Time To Define An Organizational Model For The Prevention And Management Of Infections Along The Surgical Pathway: A Worldwide Cross-Sectional Survey, Massimo Sartellli, John E. Mazuski, Et Al.

2020-Current year OA Pubs

No abstract provided.

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A Covid-19 First Evaluation Clinic At A University Hospital In Turkey, Gülçi̇n Telli̇ Di̇zman, Gökhan Metan, Çağlayan Merve Ayaz Ceylan, Hayri̇ye Altunay, Mertcan Uzun, Gamze Gürsoy, Zahi̇t Taş, Gi̇zem Karahan, Fari̇da Ahmadova, Tuğba Saricaoğlu, Zeynep Cansu Çalişkan, Alpaslan Alp, Meli̇ha Çağla Sönmezer, Ahmet Çağkan İnkaya, Ahmet Görkem Er Jan 2022

A Covid-19 First Evaluation Clinic At A University Hospital In Turkey, Gülçi̇n Telli̇ Di̇zman, Gökhan Metan, Çağlayan Merve Ayaz Ceylan, Hayri̇ye Altunay, Mertcan Uzun, Gamze Gürsoy, Zahi̇t Taş, Gi̇zem Karahan, Fari̇da Ahmadova, Tuğba Saricaoğlu, Zeynep Cansu Çalişkan, Alpaslan Alp, Meli̇ha Çağla Sönmezer, Ahmet Çağkan İnkaya, Ahmet Görkem Er

Turkish Journal of Medical Sciences

Background/aim: We aimed to analyze the usefulness of such a reserved area for the admission of the patients' symptoms suggesting COVID-19 and compare the demographic and clinical characteristics of the patients with COVID-19 and without COVID-19 who were admitted to C1 during the first month of the COVID-19 outbreak in our hospital. Materials and methods: A new area was set up in Hacettepe University Adult Hospital to limit the contact of COVID-19 suspicious patients with other patients, which was named as COVID-19 First Evaluation Outpatient Clinic (C1). C1 had eight isolation rooms and two sampling rooms for SARS-CoV-2 polymerase-chain-reaction (PCR). …

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Evaluation Of Clinical And Laboratory Findings In Severe Group Covid-19 Pregnants Without Comorbidity, Fatma Bozkurt, Ömer Çoşkun, Sevda Yeleç, Muhammed Bekçi̇başi, Muhammet Asena, İhsan Bağli Jan 2022

Evaluation Of Clinical And Laboratory Findings In Severe Group Covid-19 Pregnants Without Comorbidity, Fatma Bozkurt, Ömer Çoşkun, Sevda Yeleç, Muhammed Bekçi̇başi, Muhammet Asena, İhsan Bağli

Turkish Journal of Medical Sciences

Background/aim: COVID - 19 disease may be seen with different clinical presentations in pregnant women. Comorbid diseases are important factors affecting the progression of this disease. In this study, we aimed to evaluate the clinical and laboratory findings in pregnant women with COVID - 19 who had no comorbid disease. Material and methods: This retrospective designed study included 217 patients with Covid PCR positive in typically COVID - 19 clinic. The patients were classified into asymptomatic, nonsevere, and severe disease groups. The symptoms, laboratory results, hospital follow- ups and intensive care records of the patients and the findings of new …

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Evaluation Of Coagulation With Teg In Patients Diagnosed Covid-19, Hülya Vatansev, Mehmet Ali̇ Karaselek, Resul Yilmaz, Serkan Küççüktürk, Ahmet Topal, Şebnem Yosunkaya, Adem Küçük, Celaletti̇n Vatansev Jan 2022

Evaluation Of Coagulation With Teg In Patients Diagnosed Covid-19, Hülya Vatansev, Mehmet Ali̇ Karaselek, Resul Yilmaz, Serkan Küççüktürk, Ahmet Topal, Şebnem Yosunkaya, Adem Küçük, Celaletti̇n Vatansev

Turkish Journal of Medical Sciences

Background and aim: A high D-dimer level may indicate the risk of coagulopathy and mortality in COVID-19 patients. Thromboelastography (TEG) is a test that evaluates clot formation and fibrinolysis in real-time, unlike routine coagulation tests. The study aimed to investigate the coagulation process with TEG in patients diagnosed with COVID-19. Materials and Methods: The study was performed at our university hospital, chest diseases outpatient clinic as a cross-section study. A total of 51 patients with 23 high D-dimer levels group (HDG) and 28 low D-dimers group (LDG) were included in the study. TEG analysis was performed at the pretreatment evaluation …

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Return Visit Characteristics Of Sars-Cov-2 Pcr-Positive Cases In A Pediatric Emergency Department, Ni̇han Şik, Durgül Özdemi̇r, Murat Duman Jan 2022

Return Visit Characteristics Of Sars-Cov-2 Pcr-Positive Cases In A Pediatric Emergency Department, Ni̇han Şik, Durgül Özdemi̇r, Murat Duman

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to evaluate return visits to the pediatric emergency department (ED) for children who were detected to be positive for SARS-CoV-2 by polymerase chain reaction (PCR). Materials and methods: Between April 2, 2020, and January 20, 2021, children aged 0 to 18 years who were detected to be SARS-CoV-2 PCR-positive and discharged from the ED were evaluated. Among them, patients who returned to the ED within 14 days of quarantine were included in the study. For the first presentation and return visit, demographics, clinical findings, laboratory and radiologic investigations, and ward/pediatric intensive care unit …

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Survival Of Biological Therapeutics In Psoriasis: Retrospective Analysis Of 3-Years Data In A Turkish Registry, Psortaksis, Kemal Özyurt, Gökmen Zararsiz, Ragip Ertaş, Ahu Cephe, Ömer Kutlu, Ömer Faruk Elmas, Muhammet Reşat Akkuş, Fatma Nur Kutlu, Mustafa Atasoy Jan 2022

Survival Of Biological Therapeutics In Psoriasis: Retrospective Analysis Of 3-Years Data In A Turkish Registry, Psortaksis, Kemal Özyurt, Gökmen Zararsiz, Ragip Ertaş, Ahu Cephe, Ömer Kutlu, Ömer Faruk Elmas, Muhammet Reşat Akkuş, Fatma Nur Kutlu, Mustafa Atasoy

Turkish Journal of Medical Sciences

Background/aim: PSORTAKSIS is a psoriasis registry, which is used for follow-up of patients in Kayseri City Education and Research Hospital, Dermatology Clinic since 2016 in Turkey. PSORTAKSIS includes demographic data, follow-up clinical findings, laboratory output, and treatment information of patients. Here, drug survivals of biologic therapeutics (BT) according to three-year data of PSORTAKSIS will be presented. Materials and methods: Drug survival of BT in PSORTAKSIS was analyzed from 2016 to March 2019. Results: 158 patients (111 of them BT-naive) with psoriasis under BT were enrolled in the current study. Drug survival analysis of patients with ongoing BT (158 treatment periods) …

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Hidden Threat In Familial Mediterranean Fever: Subclinical Inflammation, Oxidative Stress And Their Relationship With Vitamin D Status, Mhd Boshr Alesh, Di̇dem Barlak Keti̇, Ayşenur Paç Kisaarslan, Sabahatti̇n Muhtaroğlu, Sema Nur Taşkin Jan 2022

Hidden Threat In Familial Mediterranean Fever: Subclinical Inflammation, Oxidative Stress And Their Relationship With Vitamin D Status, Mhd Boshr Alesh, Di̇dem Barlak Keti̇, Ayşenur Paç Kisaarslan, Sabahatti̇n Muhtaroğlu, Sema Nur Taşkin

Turkish Journal of Medical Sciences

Background/aim: Vitamin D levels have been investigated in children with familial Mediterranean fever (FMF), but the relationship between vitamin D status and inflammation/oxidative stress indicators could not be clearly demonstrated. This study aimed to investi- gate the relationship between subclinical inflammation/oxidative stress and vitamin D status in children with FMF during an attack-free period. Materials and methods: In the cross-sectional study, ninety children with FMF in the attack-free period and 30 healthy children were included. Patients were grouped according to their vitamin D status (< 20, 20-29, and 30-100 ng/mL). The groups were compared in terms of pentraxin 3 (PTX-3), total oxidant status (TOS), and total antioxidant status (TAS). Multivariable linear regression analysis was performed to identify factors associated with vitamin D status. Results: PTX-3 levels were significantly higher in patients with vitamin D insufficiency (20-29 ng/mL) than in the group with vitamin D sufficient (30-100 ng/mL). Patients with vitamin D deficiency (< 20 ng/mL) had higher TOS. A strong negative correlation was ob- served between vitamin D levels and TOS (p = 0.003). Subclinical inflammation (PTX-3 ≥ 0.640) and high TOS levels were negatively associated with vitamin D levels. Conclusion: Subclinical inflammation and oxidative stress were negatively associated with vitamin D levels in patients with FMF dur- ing an attack-free period. Sufficient vitamin D levels are important in fighting subclinical inflammation and oxidative stress in children with FMF.

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Pleuroparenchymal Fibroelastosis In Systemic Sclerosis-Associated Interstitial Lung Disease, Alper Sari, Ömer Önder, Berkan Armağan, Ertuğrul Çağri Bölek, Bayram Fari̇soğullari, Emre Bi̇lgi̇n, Gözde Kübra Yardimci, Orhan Maci̇t Ariyürek, Ali̇ Akdoğan Jan 2022

Pleuroparenchymal Fibroelastosis In Systemic Sclerosis-Associated Interstitial Lung Disease, Alper Sari, Ömer Önder, Berkan Armağan, Ertuğrul Çağri Bölek, Bayram Fari̇soğullari, Emre Bi̇lgi̇n, Gözde Kübra Yardimci, Orhan Maci̇t Ariyürek, Ali̇ Akdoğan

Turkish Journal of Medical Sciences

Background/aim: To explore the frequency and clinical associations of radiologic pleuroparenchymal fibroelastosis (PPFE) in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD). Materials and methods: In this single-center retrospective study, high resolution computed tomography (HRCT) images of 105 patients with SSc-ILD were examined for the presence of PPFE. Demographic, clinical, laboratory, and pulmonary function test (PFT) data of patients with and without PPFE were compared. Results: PPFE was detected in 19 (18.1%) patients (`definite PPFE' in 13 and `consistent with PPFE' in 6 patients). Patients with PPFE had higher age and longer disease duration than PPFE (-) patients (p < 0.05 for both). Radiologic usual interstitial pneumoniae (UIP) pattern was more frequent (26.3% vs. 4.7%, p = 0.01) and median force vital capacity (FVC) was lower in patients with PPFE (64% vs. 82%, p = 0.005). Spontaneous pneumothorax developed in one patient with PPFE. More deaths occured in PPFE (+) group during follow-up (31% vs. 11%, p = 0.04). Conclusion: PPFE on HRCT is not uncommon in SSc-ILD and is associated with radiologic UIP pattern and worse lung functions. Further studies are needed to elucidate the prognostic value of PPFE in SSc-ILD.

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The Relationship Between Hidradenitis Suppurativa And Irritable Bowel Syndrome: A Cross-Sectional Study, Abdullah Demi̇rbaş, Ömer Faruk Elmas, Hedi̇ye Eker, Gözde Ulutaş Demi̇rbaş, Recep Dursun, Mustafa Atasoy, Ümi̇t Türsen, Torello Lotti̇ Jan 2022

The Relationship Between Hidradenitis Suppurativa And Irritable Bowel Syndrome: A Cross-Sectional Study, Abdullah Demi̇rbaş, Ömer Faruk Elmas, Hedi̇ye Eker, Gözde Ulutaş Demi̇rbaş, Recep Dursun, Mustafa Atasoy, Ümi̇t Türsen, Torello Lotti̇

Turkish Journal of Medical Sciences

Background/aim: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder in which one experiences abdominal pain, tension, cramping, bloating, and changes in the form and frequency of defecation, without an underlying organic disease. Many skin diseases have been reported to be more common in people with functional bowel disease. To our knowledge, however, no previous study investigated the potential relationship between hidradenitis suppurativa (HS) and IBS. In this study, we aimed to examine the potential association between IBS and HS. Materials and methods: Patients with HS and healthy subjects were enrolled in this cross-sectional study. All participants were assessed for …

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Predictors Of Postendoscopic Retrograde Cholangiopancreatography Associated Cholangitis: A Retrospective Cohort Study, Hasan Yilmaz, Burcu Koçyi̇ği̇t Jan 2022

Predictors Of Postendoscopic Retrograde Cholangiopancreatography Associated Cholangitis: A Retrospective Cohort Study, Hasan Yilmaz, Burcu Koçyi̇ği̇t

Turkish Journal of Medical Sciences

Background/aim: Post-ERCP cholangitis (endoscopic retrograde cholangiopancreatography) and associated sepsis can be life- threatening. Despite the wealth of studies on post-ERCP pancreatitis risk factors, there is limited data on post-ERCP cholangitis. This study aimed to investigate the rates, predictors, and outcomes of post-ERCP cholangitis. Materials and methods: A retrospective review of 452 ERCP cases performed by a single endoscopist at a tertiary center between March 2019 and February 2021 was performed. Patient-related, organizational and periprocedural factors that could affect post-ERCP cholangitis were evaluated. Predictors of post-ERCP cholangitis were determined by multivariable analysis. Results: The post-ERCP cholangitis rate was 19.5%. Cholangiocarcinoma (OR …

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Evaluation Of The Contribution Of Fine-Needle Non-Aspiration Cytology To Diagnosis In Cases With Pulmonary Malignant Lesions, Şenay Yilmaz, Güntülü Ak, Selma Meti̇ntaş, Emi̇ne Dündar, Muzaffer Meti̇ntaş Jan 2022

Evaluation Of The Contribution Of Fine-Needle Non-Aspiration Cytology To Diagnosis In Cases With Pulmonary Malignant Lesions, Şenay Yilmaz, Güntülü Ak, Selma Meti̇ntaş, Emi̇ne Dündar, Muzaffer Meti̇ntaş

Turkish Journal of Medical Sciences

Background/aim: Fine-needle non-aspiration cytology (FNNAC) is an easy-to-apply, minimally invasive diagnostic method that contributes to the diagnosis and staging of lung cancer. FNNAC can be performed from peripheral lymph nodes as well as in peripheral lung lesions. This study aimed to evaluate the contribution of FNNAC performed from peripheral lesions or lymph nodes to diagnosis in patients with pulmonary malignant lesions. Materials and methods: FNNAC was applied from a peripherally located mass in the lung, chest wall lesion, or peripheral lymph node using a needle without an injector or active suction. The collected material was evaluated using the cytoblock method. …

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Selective Venous Sampling In Primary Hyperparathyroidism: Is It Worth Doing?, Selda Gücek Haci̇yanli, Ni̇han Acar, Ömür Balli, Nezahat Erdoğan, Mehmet Haci̇yanli Jan 2022

Selective Venous Sampling In Primary Hyperparathyroidism: Is It Worth Doing?, Selda Gücek Haci̇yanli, Ni̇han Acar, Ömür Balli, Nezahat Erdoğan, Mehmet Haci̇yanli

Turkish Journal of Medical Sciences

Background/aim: Accurate preoperative localization of the culprit gland is the key point for the surgical treatment of primary hyperparathyroidism. Conventional imaging techniques (ultrasound and Tc99m sestamibi scintigraphy) are usually adequate for preoperative localization. However, in some patient groups, additional imaging modalities may be required since noninvasive techniques may fail. In this study, we aimed to evaluate the diagnostic value of selective parathyroid venous sampling in patients with unclear noninvasive localization tests. Materials and methods: Among 513 cases who underwent parathyroidectomy due to primary hyperparathyroidism, twelve cases (2.3%) were undergone selective parathyroid venous sampling and were included in the study. Age, …

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The Impact Of Jak2v617f Mutation On Philadelphia-Negative Myeloproliferative Neoplasms, Ezgi̇ Şahi̇n, İpek Yönal Hi̇ndi̇lerden, Fehmi̇ Hi̇ndi̇lerden, Aynur Aday, Meli̇ha Nalçaci Jan 2022

The Impact Of Jak2v617f Mutation On Philadelphia-Negative Myeloproliferative Neoplasms, Ezgi̇ Şahi̇n, İpek Yönal Hi̇ndi̇lerden, Fehmi̇ Hi̇ndi̇lerden, Aynur Aday, Meli̇ha Nalçaci

Turkish Journal of Medical Sciences

Background/aim: JAK2V617F mutation is expressed in almost all polycthemia vera (PV), 55% of essential thrombocythemia (ET), and 65% of primary myelofibrosis (PMF) patients. Studies investigating phenotypic effects of JAK2V617F mutation on Philadelphia- negative myeloproliferative neoplasms (Ph-negative MPNs) have reported controversial results. This study aims to determine the impact of JAK2V617F mutation on clinical phenotype and outcome in Ph-negative MPNs. Materials and methods: Clinical correlates and long-term prognostic relevance of the JAK2V617F mutation were analyzed in 410 Ph- negative MPNs-170 ET, 135 PV, 105 PMF- from two institutions and followed for a mean of 76.7 months (SD 62.1) (mean 87 months …

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Evaluation Of Atrial Fibrosis In Atrial Fibrillation Patients With Three Different Methods, Cem Çöteli̇, Tuncay Hazirolan, Kudret Aytemi̇r, Ahmet Gürkan Erdemi̇r, Emi̇ne Ni̇lay Bakir, Uğur Canpolat, Hi̇kmet Yorgun, Ahmet Hakan Ateş, Ergün Bariş Kaya, Zeli̇ha Günnur Di̇kmen, Necla Özer Jan 2022

Evaluation Of Atrial Fibrosis In Atrial Fibrillation Patients With Three Different Methods, Cem Çöteli̇, Tuncay Hazirolan, Kudret Aytemi̇r, Ahmet Gürkan Erdemi̇r, Emi̇ne Ni̇lay Bakir, Uğur Canpolat, Hi̇kmet Yorgun, Ahmet Hakan Ateş, Ergün Bariş Kaya, Zeli̇ha Günnur Di̇kmen, Necla Özer

Turkish Journal of Medical Sciences

Background/aim: The presence of atrial fibrosis has already been known as a risk factor for atrial fibrillation (AF) development. We aimed to evaluate atrial fibrosis with previously defined three different methods, which were cardiac magnetic resonance imaging (C-MRI), echocardiographic strain imaging, and biomarkers and show the relationship between these methods in patients with AF scheduled for cryoballoon ablation. Materials and methods: A total of 30 patients were enrolled. Atrial T1 relaxation durations were measured using C-MRI before the procedure of atrial fibrillation catheter ablation. Fibroblast growth factor-21 (FGF-21) and fibroblast growth factor-23 (FGF-23) levels were measured at serum derived from …

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A Comparison Of Angled (D-Blade) And Macintosh (C-Mac) Videolaryngoscopes For Simulated Pediatric Difficult Airway: A Randomized Single-Blind Study, Alparslan Kuş, Can Aksu, Hadi̇ Ufuk Yörükoğlu, Volkan Alparslan, Kami̇l Toker Jan 2022

A Comparison Of Angled (D-Blade) And Macintosh (C-Mac) Videolaryngoscopes For Simulated Pediatric Difficult Airway: A Randomized Single-Blind Study, Alparslan Kuş, Can Aksu, Hadi̇ Ufuk Yörükoğlu, Volkan Alparslan, Kami̇l Toker

Turkish Journal of Medical Sciences

Background/aim: Being prepared for difficult airway (DA) is nevertheless of great importance. Failed or delayed tracheal intubation (TI) can increase morbidity and mortality, and the pediatric population is more prone to hypoxia. With the development of different types of videolaryngoscope (VL), these have become the device of choice in patients with DA. Our primary aim was to compare intubation times with D-blade and Macintosh blade of Storz C-MAC® in a simulated pediatric DA scenario with this randomized controlled trial. Materials and methods: Children aged 1-5 years scheduled for elective surgery were included in the study. Patients were randomized into two …

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The Effects Of A Combination Treatment With Mesenchymal Stem Cell And Platelet-Rich Plasma On Tendon Healing: An Experimental Study, İlker Uyar, Zeynep Altuntaş, Siddika Findik, Mehmet Emi̇n Cem Yildirim, Serhat Yarar, Murat Aktan, Ahmet Avci Jan 2022

The Effects Of A Combination Treatment With Mesenchymal Stem Cell And Platelet-Rich Plasma On Tendon Healing: An Experimental Study, İlker Uyar, Zeynep Altuntaş, Siddika Findik, Mehmet Emi̇n Cem Yildirim, Serhat Yarar, Murat Aktan, Ahmet Avci

Turkish Journal of Medical Sciences

Background/Aim: The objective of this study was to investigate the effects that the application of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) following tendon repair have on the strength and healing of the tendon and also to examine the possible mechanisms of action that take place. Materials and methods: The Achilles tendons of 80 rats were repaired and divided into eight groups. Following the repairs, MSCs obtained from humans were injected into the rat tendons in groups 1 and 2, a combination of MSCs from humans and PRP from rats was injected into the tendons in groups 3 and …

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Striatal Dopaminergic Neurons As A Potential Target For Gdnf Based Ischemic Stroke Therapy, Mustafa Çağlar Beker, Merve Beker, Ahmet Burak Çağlayan, Busenur Bolat, Ülkan Kiliç, Gamze Köse, Ertuğrul Kiliç Jan 2022

Striatal Dopaminergic Neurons As A Potential Target For Gdnf Based Ischemic Stroke Therapy, Mustafa Çağlar Beker, Merve Beker, Ahmet Burak Çağlayan, Busenur Bolat, Ülkan Kiliç, Gamze Köse, Ertuğrul Kiliç

Turkish Journal of Medical Sciences

Background/aim: Glial cell-line-derived neurotrophic factor (GDNF) is a well-known regulatory neurotrophic factor on dopaminergic neurons. Several pathologies have been documented so far in case of any impairment in the dopaminergic system. This study aimed to investigate the potential protective role of lentiviral GNDF delivery on the small population of tyrosine hydroxylase (TH) positive dopamine producing striatal neurons after ischemic stroke. Materials and methods: Fourteen C57BL/6J male mice (8-10 weeks) were intracerebrally treated with lentiviral GDNF (Lv-GDNF) or vehicle. Ten days after injections, cerebral ischemia was induced by blockage of the middle cerebral artery. Animals were terminated 72 h after ischemia, …

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Modulatory Effect Of Resveratrol And Melatonin On Natural Killer Cell Activity And Adrenomedullin In Diabetic Rats, Fati̇h Özçeli̇k, Fati̇h Hacimustafaoğlu, Alpaslan Tanoğlu Jan 2022

Modulatory Effect Of Resveratrol And Melatonin On Natural Killer Cell Activity And Adrenomedullin In Diabetic Rats, Fati̇h Özçeli̇k, Fati̇h Hacimustafaoğlu, Alpaslan Tanoğlu

Turkish Journal of Medical Sciences

Background/aim: Epidemiological evidence suggests that diabetes poses a high risk for many chronic diseases, especially cardiovascular diseases, and cancer by stimulating many inflammatory and immunological pathogenic mediators and affecting natural killer (NK)-cell activity. In this study, the effects of melatonin and resveratrol on IL-6, TNF-alpha, oxidant/antioxidant capacity, NK-cell activity, and mid-regional proadrenomedullin (MR-proADM) levels of diabetic rats were investigated. Materials and methods: In the study, 28 Sprague Dawley rats were randomly divided into the control group (group I) and 3 streptozotocin- induced diabetes mellitus (DM) groups (group II, III, and IV), each group consisting of 7 rats. Five mg/kg/day melatonin …

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Patterns Of Postmastectomy Radiation Therapy In Clinically Node-Positive Breast Cancerpatients With Pathologically Negative Lymph Nodes After Neoadjuvant Chemotherapy, Mutlay Sayan, Irina Vergalasova, Mridula George, Maria Kowzun, Lindsay Potdevin, Shicha Kumar, Bruce Haffty, Nisha Ohri Jan 2022

Patterns Of Postmastectomy Radiation Therapy In Clinically Node-Positive Breast Cancerpatients With Pathologically Negative Lymph Nodes After Neoadjuvant Chemotherapy, Mutlay Sayan, Irina Vergalasova, Mridula George, Maria Kowzun, Lindsay Potdevin, Shicha Kumar, Bruce Haffty, Nisha Ohri

Turkish Journal of Medical Sciences

Background/aim: To analyze postmastectomy radiation therapy (PMRT) utilization and its association with overall survival (OS) in patients presenting with node-positive breast cancer who are pathologically node-negative (ypN0) after neoadjuvant chemotherapy (NAC). Materials and methods: Using the National Cancer Data Base (NCDB), we identified patients diagnosed between 2004 and 2013 with clinical T1-4 node-positive nonmetastatic breast cancer who received NAC and underwent mastectomy with pathologically negative lymph node sampling. Multivariable regression models identified factors associated with PMRT use. The Cox proportional hazards model was used to evaluate predictors of mortality. Results: The study included 8766 clinically node-positive patients who met the …

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Factors That Affect Placental Retinol Transfer In Preterm Infants And Mothers With Retinoldeficiency, Kadi̇r Şerafetti̇n Tekgündüz, Di̇lara Di̇lek, Mustafa Kara, Nuri̇nni̇sa Öztürk, Si̇bel Ejder Tekgündüz Jan 2022

Factors That Affect Placental Retinol Transfer In Preterm Infants And Mothers With Retinoldeficiency, Kadi̇r Şerafetti̇n Tekgündüz, Di̇lara Di̇lek, Mustafa Kara, Nuri̇nni̇sa Öztürk, Si̇bel Ejder Tekgündüz

Turkish Journal of Medical Sciences

Background/aim: The retinol level and retinol delivery to the placenta may vary depending on various factors involving the mother and newborn. The present study evaluates the factors affecting retinol levels in newborns and the transplacental retinol passage in preterm newborns. Materials and methods: In this prospective cohort study, the retinol and retinol binding protein (RBP) in the umbilical cord blood of 44 preterm infants with a gestation age of

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Clinical And Imaging Findings Of Patients Diagnosed With Adenovirus-Positivepneumonia During 2015-2019 In Shanghai, China, Chunrong Huang, Dong Wei, Yahui Liu, Guo Chao Shi Jan 2022

Clinical And Imaging Findings Of Patients Diagnosed With Adenovirus-Positivepneumonia During 2015-2019 In Shanghai, China, Chunrong Huang, Dong Wei, Yahui Liu, Guo Chao Shi

Turkish Journal of Medical Sciences

Background/aim: This study was to describe the clinical characteristics, chest CT image findings, and potential role of T cells immunity in adenovirus positive pneumonia. Materials/methods: In this retrospective study, medical records of 53 adult Adv+ patients who were admitted to the Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, from May 2015 to August 2019 were included. The presence of adenovirus and other respiratory viruses was detected using polymerase chain reaction of throat swabs samples. Clinical features and chest computed tomography (CT) findings were compared between patients with Adv+ pneumonia and Adv+ non-pneumonia. Results: The top 3 most commonly …

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The Role Of Il-6 And Osteoprotegerin In Bone Metabolism In Patients With Graves' Disease, Tülay Omma, Çi̇ğdem Yücel, Erdi̇m Sertoğlu, Sevde Nur Firat, Cavi̇t Çulha, Taner Özgürtaş Jan 2022

The Role Of Il-6 And Osteoprotegerin In Bone Metabolism In Patients With Graves' Disease, Tülay Omma, Çi̇ğdem Yücel, Erdi̇m Sertoğlu, Sevde Nur Firat, Cavi̇t Çulha, Taner Özgürtaş

Turkish Journal of Medical Sciences

Background/aim: Increased bone turnover is a hallmark of hyperthyroidism. The underlying factors of how thyroid hormones affect bone cells are still under the spotlight. Previous studies indicated serum osteoprotegerin (OPG), receptor activator of NF-kB ligand (RANKL), and interleukin-6 (IL-6) as mediators of the effect of thyroid hormones on bone metabolism. Ultimately, the present research aimed to examine the association of IL-6 with OPG and RANKL in patients with hyperthyroidism. Materials and methods: We carried out this study with 39 newly diagnosed and untreated Graves' patients and 43 healthy controls. In addition to routine tests, we measured serum OPG, RANKL, and …

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The Evaluation Of Disease Awareness, Caregiver Burden, And Workday Loss In Caregivers Ofcopd Patients, Ayşe Baha, Nurdan Köktürk, Burcu Öztürk Şahi̇n, Eli̇f Yildirim, İpek Özmen, Alev Gürgün, Ayşe Füsun Topçu, Evri̇m Eylem Akpinar, Funda Elmas Uysal, Hadi̇ce Seli̇moğlu Şen, Nalan Ogan, Yeşi̇m Önder, Ömer Tamer Doğan, Mehmet Polatli, Züleyha Bi̇ngöl Jan 2022

The Evaluation Of Disease Awareness, Caregiver Burden, And Workday Loss In Caregivers Ofcopd Patients, Ayşe Baha, Nurdan Köktürk, Burcu Öztürk Şahi̇n, Eli̇f Yildirim, İpek Özmen, Alev Gürgün, Ayşe Füsun Topçu, Evri̇m Eylem Akpinar, Funda Elmas Uysal, Hadi̇ce Seli̇moğlu Şen, Nalan Ogan, Yeşi̇m Önder, Ömer Tamer Doğan, Mehmet Polatli, Züleyha Bi̇ngöl

Turkish Journal of Medical Sciences

Background/aim: Our aim is to determine the caregiver burden of chronic obstructive lung disease (COPD) patient's caregivers, and to determine whether there is a workday loss. Materials and methods: 252 COPD patients and their caregivers were included. Disease information of the patients were recorded and a questionnaire was applied. Socio-demographic characteristics of the caregivers were recorded and a questionnaire consisting of 24 questions including COPD disease, treatment and loss of working days, and the Zarit Scale were used. Results: 128(50.8%) of the patients according to GOLD were group-D, 97(38.5%) of the patient's relatives were working, 62(24.7%) were not able to …

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A New Device For Bronchoscopy For Better Protection, Aslihan Gürün Kaya, Mi̇raç Öz, İnci̇fer Karnak Orhun, Serhat Erol, Aydin Çi̇ledağ, Demet Karnak, Akin Kaya Jan 2022

A New Device For Bronchoscopy For Better Protection, Aslihan Gürün Kaya, Mi̇raç Öz, İnci̇fer Karnak Orhun, Serhat Erol, Aydin Çi̇ledağ, Demet Karnak, Akin Kaya

Turkish Journal of Medical Sciences

Background/aim: During the COVID-19 pandemic, the risk of transmission of SARS-CoV-2 has not been precisely known in bronchoscopy procedures. We have designed a cabinet device called Ankara University Bronchoscopy Cabinet (Aubrocab® ) to protect healthcare. We aimed to evaluate preventing effect of Aubrocab® on aerosol spreading by measuring the particles in the bronchoscopy suite. Materials and methods: The patients were categorized into two groups as those who underwent bronchoscopy with and without Aubrocab® . We measured PM 0.5 levels before and after bronchoscopy in the bronchoscopy suite. Results: A total of 82 patients, 62 of whom underwent bronchoscopy with Aubrocab® …

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Delirium, Dementia, And Depression (3d) Assessment Of Older Patients In The Emergencydepartment: 5-Year Survival Analysis, İsa Kiliçaslan, Myat Soe Thet, Hüseyi̇n Berkay Karahacioğlu, Merve Sevi̇m Artykov, Zekeri̇ya Ülger, Mehmet Ali̇ Aslaner, Banu Kiliçaslan Jan 2022

Delirium, Dementia, And Depression (3d) Assessment Of Older Patients In The Emergencydepartment: 5-Year Survival Analysis, İsa Kiliçaslan, Myat Soe Thet, Hüseyi̇n Berkay Karahacioğlu, Merve Sevi̇m Artykov, Zekeri̇ya Ülger, Mehmet Ali̇ Aslaner, Banu Kiliçaslan

Turkish Journal of Medical Sciences

Background: While physicians tend to emphasize on physical medical problems, behavioral and cognitive disorders of geriatric patients are usually missed, especially in emergency settings. The aim of the study was to determine the prevalence of delirium, dementia, and depression (3D) among older patients (≥65 years old) in the Emergency Department (ED) and to evaluate the effect of geriatric 3D on the 6-month and 5-year mortality. Materials and methods: This was a prospective, observational cohort study, including 415 patients from eligible 512 consecutive older patients, who are 65 years of age or older, presenting to the ED of a tertiary care …

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Clinically Mild Encephalitis/Encephalopathy With A Reversible Splenial Lesion Of Thecorpus Callosum In Childhood: A Single-Center Experience, Hali̇l Çeli̇k, Betül Emi̇ne Deri̇nkuyu, Erhan Aksoy, Ülkühan Öztoprak, Nesri̇n Ceylan, Ebru Azapağasi, Suna Özdem, Melahat Melek Oğuz, Deni̇z Yüksel Jan 2022

Clinically Mild Encephalitis/Encephalopathy With A Reversible Splenial Lesion Of Thecorpus Callosum In Childhood: A Single-Center Experience, Hali̇l Çeli̇k, Betül Emi̇ne Deri̇nkuyu, Erhan Aksoy, Ülkühan Öztoprak, Nesri̇n Ceylan, Ebru Azapağasi, Suna Özdem, Melahat Melek Oğuz, Deni̇z Yüksel

Turkish Journal of Medical Sciences

Background/aim: Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a rare clinicoradiological syndrome that typically presents with central nervous system symptoms such as loss of consciousness, seizure, headache, and ophthalmoparesis. Materials and methods: Here, we highlight the characteristics of this syndrome together with the clinical and MRI findings of 6 pediatric patients with MERS. Results: Between January 2017 and October 2020, 6 patients with MERS (3 boys and 3 girls) presented to our center. The mean age was 122 ± 54.6 (min-max: 44-180) months. None of the patients had a chronic disease. In our study, infectious agents were detected …

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Linguistic Validation Of A Widely Used Recovery Score: Quality Of Recovery-15 (Qor-15), Umut Kara, Fati̇h Şi̇mşek, Hasan Kamburoğlu, Mehmet Özgür Özhan, Ümi̇t Alakuş, Mehmet Emi̇n İnce, Sami̇ Eksert, Gökhan Özkan, Mehmet Burak Eşki̇n, Serkan Şenkal Jan 2022

Linguistic Validation Of A Widely Used Recovery Score: Quality Of Recovery-15 (Qor-15), Umut Kara, Fati̇h Şi̇mşek, Hasan Kamburoğlu, Mehmet Özgür Özhan, Ümi̇t Alakuş, Mehmet Emi̇n İnce, Sami̇ Eksert, Gökhan Özkan, Mehmet Burak Eşki̇n, Serkan Şenkal

Turkish Journal of Medical Sciences

Background/aim: The quality of recovery-15 (QoR-15) is a patient reported outcome questionnaire that measures the quality of recovery after surgery and anesthesia. The QoR-15 has been validated in many languages; Turkish version of the QoR-15 has not yet been established. The aims of this study were to translate the QoR-15 questionnaire into Turkish and to perform a full psychometric evaluation of the Turkish version. Materials and methods: After translating the original English version of the QoR-15 scale into Turkish, the QoR-15T scale was psychometrically validated. This process included validity, reliability, responsiveness, feasibility. The QoR-15T was evaluated before the surgery and …

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Development Of Speech Intelligibility In Geriatric Individuals With Hearing Loss, Bünyami̇n Çildir, Meral Di̇dem Türkyilmaz Jan 2022

Development Of Speech Intelligibility In Geriatric Individuals With Hearing Loss, Bünyami̇n Çildir, Meral Di̇dem Türkyilmaz

Turkish Journal of Medical Sciences

Background/aim: In our study, we aimed to evaluate the hearing aid benefit and speech intelligibility with hearing aids using objective and subjective measurements, according to the type of hearing loss in elderly individuals who used different types of hearing aids. Materials and methods: The objective and subjective findings from a total of 47 elderly individuals between the ages of 60 and 84, who used regular hearing aids for at least six months, and who were diagnosed with different types and degrees of hearing loss were evaluated by scanning them retrospectively. Results: In our study, the Adaptive Turkish matrix sentence test …

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Proximal Femoral Nail Antirotation Versus Cemented Calcar-Replacement Hemiarthroplastyfor Unstable Intertrochanteric Fracture In Elderly: An Overall Survival Study, Fati̇h Durgut, Erdem Şahi̇n, Sadetti̇n Çi̇ftci̇, Bahatti̇n Kerem Aydin Jan 2022

Proximal Femoral Nail Antirotation Versus Cemented Calcar-Replacement Hemiarthroplastyfor Unstable Intertrochanteric Fracture In Elderly: An Overall Survival Study, Fati̇h Durgut, Erdem Şahi̇n, Sadetti̇n Çi̇ftci̇, Bahatti̇n Kerem Aydin

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to compare the perioperative complications and overall survival of patients who underwent proximal femoral nail antirotation (PFNA) and patients who underwent cemented calcar-replacement hemiarthroplasty (CCRH) for unstable intertrochanteric fracture in patients aged 75 years and older. Materials and methods: A total of 94 patients who underwent PFNA or CCRH between 2010 and 2012 because of femur fracture (A2.2 and A2.3 according to the Arbeitsgemeinschaft für Osteosynthesefragen/Orthopaedic Trauma Association (AO/OTA) classification) were analyzed retrospectively. Hospitalization times, blood transfusion needs, reoperation rates, and overall survival were compared. Results: Forty-eight patients in the PFNA group and …

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Pasireotide Treatment In Cushing's Disease: A Single Tertiary Center's Experience, Serdar Şahi̇n, Gular Kari̇mova, Şeyda Gül Özcan, Emre Durcan, Hande Mefkure Özkaya, Pinar Kadioğlu Jan 2022

Pasireotide Treatment In Cushing's Disease: A Single Tertiary Center's Experience, Serdar Şahi̇n, Gular Kari̇mova, Şeyda Gül Özcan, Emre Durcan, Hande Mefkure Özkaya, Pinar Kadioğlu

Turkish Journal of Medical Sciences

Background/aim: Cushing's disease (CD), which cannot be controlled by surgery, requires medical treatment. In this situation, treatments with long-term effectiveness and safety profiles are needed. We aimed to evaluate the effects and adverse effects of pasireotide treatment in CD. Materials and methods: Patients who were followed up for CD and treated with pasireotide between 2014-2020 at Cerrahpaşa Medical Faculty, were evaluated retrospectively. The efficacy and adverse effects of pasireotide were evaluated in this study. Results: Thirty-two patients were evaluated. The mean duration of treatment was 26.5 [range, 12.0-37.0] months. The 24-h urinary free cortisol (UFC) decreased 46% during the treatment …

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