Medicine and Health Sciences Commons^™

Self-Care In The Workplace, Crystal Wilson Rn, Delicia Walker Rn, Alyssa Reardon Rn

Nursing Research and Scholarship 2022

Holistic and Nursing Scholarship Symposium Event Posters

Maternal-Fetal Immune Responses In Pregnant Women Infected With Sars-Cov-2, Arya Hanjagi, Arya Revankar, Meghana Sunkara, Tvisha Vanteru

VCU's Medical Journal Club: The Work of Future Health Professionals

This study aimed to provide more insight into how much of an effect these unique maternal-fetal immune responses have during pregnancy and examine the likelihood of placental infections. Pregnant women with positive RT-PCR results for SARS-CoV-2 and healthy gestational age-matched controls made up the study's two primary groups. The study comprised a total of 23 women, 12 women (8 asymptomatic; 1 with mild symptoms; 3 had severe COVID-19 (requiring oxygen supplementation). Sections from the center of the placenta and placental disk were taken and histologically examined. Researchers obtained and analyzed differences in SARS-CoV-2 human maternal peripheral blood, umbilical cord blood, …

The Influence Of An Acute Bout Of Aerobic Exercise On Vascular Endothelial Function In Moderate Stages Of Chronic Kidney Disease, Jeffrey S. Forsse, Zacharias Papadakis, Matthew N. Peterson, James Kyle Taylor, Burritt W. Hess, Nicholas Schwedock, Dale C. Allison, Jackson O. Griggs, Ronald L. Wilson, Peter W. Grandjean

Faculty and Student Publications

Chronic kidney disease (CKD) is directly influenced by the deleterious effects of systemic inflammation and oxidative stress. The vascular endothelium may transiently respond to aerobic exercise and improve post-exercise vascular renal function in moderate stages of CKD. Brachial artery flow-mediated dilation (FMD) is a nitric-oxide-dependent measure of endothelial function that is transiently potentiated by exercise. The purpose of the study was to determine the acute influence of a single bout of high-intensity interval exercise (HIIE) or steady-state moderate-intensity exercise (SSE) on endothelial dysfunction in moderate stages of CKD. Twenty participants (n = 6 men; n = 14 women) completed 30 …

Physical Therapy Interventions And Outcomes In A Patient With Transfemoral Amputation Following Sound Side Total Knee Arthroplasty: A Case Report, Scott Love, Debra Gray, Jenna Yent, Michael Jason Highsmith

Physical Therapy Collection

Background: Following a transfemoral amputation (TFA), osteoarthritis (OA) on the sound limb may occur secondary to overuse. Potential causative factors include gait abnormalities, increased knee load, and performing hopping activities without a prosthesis. Unilateral TFA patients may require a total knee arthroplasty (TKA) to improve function.

Case Description and Methods: A 56-year-old male with a TFA who was diagnosed with left knee OA and was classified as a limited community ambulator underwent a TKA to restore function. The purpose of this case report is to determine the benefits of standard physical therapy (PT) augmented by a high intensity, whole-body …

The Perceived Impact Of Holotropic Breathwork: An Interpretive Phenomenological Analysis, Felipe Landaeta Farizo

International Journal of Transpersonal Studies

Holotropic Breathwork (HB) is a method of self-exploration developed by Stanislav and Christina Grof. Research has only just begun to investigate the effects of HB, while the possible influence of the context and other features of HB within the experience and its impact have not been studied in depth. This qualitative study investigated the perceived impact of HB on 6 women and 6 men (ages 25-67) in Chile, using Interpretive Phenomenological Analysis (IPA), an emergent method developed specifically to work with these types of subjective issues. Results revealed 10 major themes involving both intrapsychic and relational features prior, during and …

Neurod1 Aav-Based Gene Therapy For Functional Brain Repair After Ischemic Injury Through In Vivo Astrocyte-To-Neuron Conversion, Marlena Ramlatchan

VCU's Medical Journal Club: The Work of Future Health Professionals

This study uses AAV based gene therapy to create an astrocyte- neuron conversion to regain functional abilities damaged by ischemic injuries. NeuroD1 treatment has shown promising results in the treatment of ischemic injuries in rodents and is heading towards clinical trials. Cognitive and motor improvements were shown. The basis of this therapy is to use functional glial cells to promote neurocellular growth, which would restore some function lost as a result of injury.

Expanding The Landscape Of Amino Acid-Rich Antimicrobial Peptides: Definition, Deployment In Nature, Implications For Peptide Design And Therapeutic Potential, Aaron P. Decker, Abraham F. Mechesso, Guangshun Wang

Journal Articles: Pathology and Microbiology

Unlike the α-helical and β-sheet antimicrobial peptides (AMPs), our knowledge on amino acid-rich AMPs is limited. This article conducts a systematic study of rich AMPs (>25%) from different life kingdoms based on the Antimicrobial Peptide Database (APD) using the program R. Of 3425 peptides, 724 rich AMPs were identified. Rich AMPs are more common in animals and bacteria than in plants. In different animal classes, a unique set of rich AMPs is deployed. While histidine, proline, and arginine-rich AMPs are abundant in mammals, alanine, glycine, and leucine-rich AMPs are common in amphibians. Ten amino acids (Ala, Cys, Gly, His, …

Comparative Transmissibility Of Sars-Cov-2 Variants Delta And Alpha In New England, Usa, Rebecca Earnest, Rockib Uddin, Nicholas Matluk, Nicholas Renzette, Katherine J. Siddle, Christine Loreth, Gordon Adams, Christopher H. Tomkins-Tinch, Mary E. Petrone, Jessica E. Rothman, Mallery I. Breban, Robert Tobias Koch, Kendall Billig, Joseph R. Fauver, Chantal B.F. Vogels, Sarah Turbett, Kaya Bilguvar, Bony De Kumar, Marie L. Landry, David R. Peaper, Kevin Kelly, Greg Omerza, Heather Grieser, Sim Meak, John Martha, Hannah H. Dewey, Susan Kales, Daniel Berenzy, Kristin Carpenter-Azevedo, Ewa King, Richard C. Huard, Sandra C. Smole, Catherine M. Brown, Timelia Fink, Andrew S. Lang, Glen R. Gallagher, Pardis C. Sabeti, Stacey Gabriel, Bronwyn L. Macinnis, New England Variant Investigation Team, Ryan Tewhey, Mark D. Adams, Daniel J. Park, Jacob E. Lemieux, Nathan D. Grubaugh

Journal Articles: Epidemiology

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant quickly rose to dominance in mid-2021, displacing other variants, including Alpha. Studies using data from the United Kingdom and India estimated that Delta was 40-80% more transmissible than Alpha, allowing Delta to become the globally dominant variant. However, it was unclear if the ostensible difference in relative transmissibility was due mostly to innate properties of Delta's infectiousness or differences in the study populations. To investigate, we formed a partnership with SARS-CoV-2 genomic surveillance programs from all six New England US states. By comparing logistic growth rates, we found that Delta …

Lineage Abundance Estimation For Sars-Cov-2 In Wastewater Using Transcriptome Quantification Techniques, Jasmijn A. Baaijens, Alessandro Zulli, Isabel M. Ott, Ioanna Nika, Mart J. Van Der Lugt, Mary E. Petrone, Tara Alpert, Joseph R. Fauver, Chaney C. Kalinich, Chantal B. F. Vogels, Mallery I. Breban, Claire Duvallet, Kyle A. Mcelroy, Newsha Ghaeli, Maxim Imakaev, Malaika F. Mckenzie-Bennett, Keith Robison, Alex Plocik, Rebecca Schilling, Martha Pierson, Rebecca Littlefield, Michelle L. Spencer, Birgitte B. Simen, Yale Sars-Cov-2 Genomic Surveillance Initiative, William P. Hanage, Nathan D. Grubaugh, Jordan Peccia, Michael Baym

Journal Articles: Epidemiology

Effectively monitoring the spread of SARS-CoV-2 mutants is essential to efforts to counter the ongoing pandemic. Predicting lineage abundance from wastewater, however, is technically challenging. We show that by sequencing SARS-CoV-2 RNA in wastewater and applying algorithms initially used for transcriptome quantification, we can estimate lineage abundance in wastewater samples. We find high variability in signal among individual samples, but the overall trends match those observed from sequencing clinical samples. Thus, while clinical sequencing remains a more sensitive technique for population surveillance, wastewater sequencing can be used to monitor trends in mutant prevalence in situations where clinical sequencing is unavailable.

The Effects Of The Covid-19 Pandemic On Postgraduate Endodontic Programs In The United States, Bianca Aboubakare, James Chen, Johnah C. Galicia

Orthodontics and Endodontics Theses

In December 2019, the coronavirus disease 2019 (COVID-19) was first identified as an acute infectious disease in Wuhan, China and subsequently led to an ongoing pandemic. At the onset of the pandemic, dental professionals were understood to face the greatest exposure risk to SARS-Cov-2 due to aerosolization of fluids from the oral cavity and respiratory airways . As a result, dental professionals, including academic institutions and their students and residents halted much of their operations to minimize exposure risks and potentially slow the spread of infection to peers and patients alike. Currently, there is little in the literature that describes …

T-Lymphocyte Tyrosine Hydroxylase Regulates T H 17 T-Lymphocytes During Repeated Social Defeat Stress, Safwan K. Elkhatib, Cassandra M. Moshfegh, Gabrielle F. Watson, Adam J. Case

Journal Articles: Cellular & Integrative Physiology

Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder which results in deleterious changes to psychological and physical health. Patients with PTSD are especially susceptible to life-threatening co-morbid inflammation-driven pathologies, such as autoimmunity, while also demonstrating increased T-helper 17 (T_H17) lymphocyte-driven inflammation. While the exact mechanism of this increased inflammation is unknown, overactivity of the sympathetic nervous system is a hallmark of PTSD. Neurotransmitters of the sympathetic nervous system (i.e., catecholamines) can alter T-lymphocyte function, which we have previously demonstrated to be partially mitochondrial redox-mediated. Furthermore, we have previously elucidated that T-lymphocytes generate their own catecholamines, and strong …

Perioperative Malignant Hyperthermia, Mitchell Mccorkle

Nursing Student Class Projects (Formerly MSN)

Abstract

Malignant Hyperthermia (MH) is a rare inherited disorder in which exposure to triggering agents such as volatile anesthetics or depolarizing neuromuscular blockers causes a hypermetabolic reaction leading to patient fatality. MH susceptible patients have a genetic mutation on the ryanodine one receptor (RYR1) in skeletal muscle, allowing uninhibited calcium release (Smith, Tranovich, & Ebraheim, 2018). Increases in free calcium result in an uncontrollable sustained muscle contraction through the excitation-contraction coupling of myosin and actin. Sustained muscle contraction rapidly consumes adenosine triphosphate stores and stimulates conversion to lactate producing anaerobic metabolism (Smith et al., 2018). Immediate recognition and treatment of …

Substance Use Disorder In The Crna, Bridget Hayes

Nursing Student Class Projects (Formerly MSN)

Substance use disorder (SUD) affects the anesthesia community disproportionally as compared to the general public (Rupprecht, 2022). It is estimated that SUD will affect 10%-15% of all anesthesia providers at some point in their careers (Rupprecht, 2022). One way that SUD affects the human body is the alteration of microRNAs, which are small segments of RNA that exist to regulate gene expression (Gowen et al., 2020). This poster will discuss how miRNAs change in the SUD-affected individual, anesthesia-specific risk factors, and signs and symptoms to identify when this disorder has affected someone else. Resources for help are available from the …

Cystic Fibrosis, India Hutchison

Nursing Student Class Projects (Formerly MSN)

Cystic fibrosis (CF) is a complex disease caused by an autosomal recessive gene mutation that results in the dysfunction of chloride transport proteins in epithelial tissues. The resultant highly viscous secretions can cause respiratory, gastrointestinal, endocrine, and reproductive complications. Although modern treatment has become more individually targeted and the average life expectancy has increased in recent years, no cure has been discovered. It affects over 80,000 people worldwide, with 30,000 affected individuals living in the United States alone. This poster aims to provide a brief overview of the pathophysiologic processes, treatment therapies, and nursing considerations for Cystic Fibrosis.

Chronic Obstructive Pulmonary Disease (Copd), Whitney R. Stant

Nursing Student Class Projects (Formerly MSN)

To make a safe anesthetic plan, a nurse anesthetist must evaluate a patient's medical history. Anesthesia providers will encounter patients with COPD requiring anesthesia. It is necessary that nurse anesthesia understands the pathophysiology and peri-operative considerations to provide safe care to COPD patients. The poster provided can be a tool to review the pathophysiology and nursing implementations of COPD. It provides information for the nurse anesthetist to apply to the perioperative setting to improve patients’ surgery outcomes. An anesthetist is always striving to provide quality anesthesia care to their patients. COPD patients require extra preparation to prevent complications from arising …

Physical Inactivity, Obesity, And The Latino Adult Population: A Literature Review, Steven Gunzelman

College of Health Sciences Posters

Physical Inactivity, Obesity, and the Latino Adult Population: A Literature Review

Abstract

Purpose: The Latino population within the United States show low levels of physical activity and have a high prevalence of obesity. The purpose of this literature review is to analyze the interaction between three different levels of the social ecological model and their impact on physical inactivity behaviors.

Methods: The databases CINAHL Plus, PubMed, and PsycINFO were searched with Latino adults as the target population. The inclusion criteria were studies focusing on Latino adults over the age of 18 that live in the United States that discuss the …

Violence Against Healthcare Workers: An Epidemic Within A Pandemic, Michaela Ramandanes

College of Health Sciences Posters

Violence and harassment towards healthcare workers has been an underlying problem throughout history. However, with the rapid and evolving onset of the COVID-19 pandemic, the risks that healthcare workers face has been a focal topic of discussion among administration, staff and the public. What was once considered an occupational hazard is now being raised as a public health issue- an epidemic within a pandemic. This literature review seeks to identify the prevalence and causes of violence and harassment towards healthcare workers. Was healthcare violence as prevalent before COVID-19? Has violence increased because patient volume increased? Additionally, this review will determine …

Allied Dental Students' Dvi Learning Outcomes Following A Multimedia Module, Samantha Vest, Brenda Bradshaw, Marsha Voelker, Ann Bruhn, Tara L. Newcomb, Sinjini Sikdar

College of Health Sciences Posters

This pilot project assessed cognitive and affective learning outcomes of allied dental students following a disaster victim identification (DVI) multi-media learning module.

A convenience sample (n=41) of senior dental hygiene and dental assisting students from two institutions completed an IRB-exempt descriptive pretest/posttest study to assess cognitive and affective changes resulting from exposure to a multimedia DVI learning module of a PowerPoint presentation with audio/video recordings. After completing the learning module, participants were presented with 10 sets of mismatched antemortem (AM) and postmortem (PM) digital bitewing radiographs to test their cognitive ability to indicate identification matches. The pretest/posttest survey was a …

Tailoring In-Clinic Patient Education To Target Outcome Improvement In Acute Low Back Pain, Trevor Mordhorst, Jake Gooing

View All Washington/Montana GME

Presented at the 2022 Virtual Northwest Medical Research Symposium

Handedness And Specimen Chirality Affect Resident Upper Extremity Motion Patterns During Arthroscopic Simulation, Joseph O'Sullivan, Adam Rosencrans, Taylor Kong, Alexandra Bray, Carolin Curtze, Andrea Herzka, Dennis Crawford, Jacqueline Brady

View All Washington/Montana GME

Presented at the 2022 Virtual Northwest Medical Research Symposium

Repurposing Of Small Molecule Inhibitor Ym-155 Inhibits High-Risk Neuroblastoma Growth By Directly Inhibiting Survivin Protein, Danielle Crystal Rouse

Theses and Dissertations

High-risk neuroblastoma (NB) is an aggressive pediatric tumor which develops from the extracranial sympathetic nervous system and accounts for almost 15% of all childhood cancer-related deaths. Current therapies include high-dose chemotherapy and radiation which have long-term toxic side-effects. Despite these intensive therapies, the overall survival rate of NB is less than 50%. Therefore, developing novel therapeutic approaches by directly targeting the molecular mechanisms that drives NB progression is very important. In the present study, we analyzed genomic datasets of 1235 NB patients and discovered that overexpression of survivin coding gene BIRC5 strongly correlates with poor overall and event-free survival of …

Transitional Caregiver Support From Nicu To Early Intervention Services., Sophia Schutt

Occupational Therapy Capstones

Transitional Caregiver Support from NICU to Early Intervention Services. Sophia B. Schutt, Dr. Julie Grabanski, Department of Occupational Therapy, University of North Dakota School of Medicine & Health Sciences, 501 North Columbia Road, Grand Forks, ND 58202

Purpose: The purpose of this project was to develop an occupation-based educational product for caregivers leaving the NICU setting and transitioning into early intervention services. The project is aimed at assessing and reducing caregiver stress levels and increasing co-occupational outcomes with their infants.

Methods: A needs assessment was conducted to evaluate the gap in caregiver education during the transition in care. The educational …

Effectiveness Of Occupational Therapy Services On Quality Of Life Among Chronically Homeless Mothers With Children, Stephanie Dullum, Caitlyn Fussy, Cierra Jacobson

Critically Appraised Topics

Chronically homeless mothers face many challenges with their quality of life due to trauma, mental illness, substance abuse, and stress that impacts the person, their environment, and occupations. Currently there is a lack of occupational therapy interventions for improving the quality of life for this population. The purpose of this critically appraised topic is to address the role of occupational therapy within the population of chronically homeless mothers and how it can improve their quality of life.

Family-Centered Care For Preschool Children With Disabilities, Kaylee Athmann, Ashley Freund, Rachel Koenig

Critically Appraised Topics

The purpose of this critically appraised topic paper was to define family-centered care, to look at family-centered care through the model of EHP, and to show the unique role occupational therapy plays in family-centered care. More specifically, we aimed to find the effects of family-centered care on health management. While family-centered care has been cited as beneficial by occupational therapists, there is a gap in these services being provided to preschoolers with disabilities.

Intervention Strategies To Combat The Impacts Of Covid-19 On Adolescents Mental Health: A Critically Appraised Topic, Rylie Garner, Lauryne Griego, Kailey Squier, Jamie Steinhoff

Critically Appraised Topics

Does sensory modulation and physical activity as an occupational therapy intervention improve mental health outcomes in adolescents resulting from the COVID-19 pandemic?

Nutrition Policy: Developing Scientific Recommendations For Food-Based Dietary Guidelines For Older Adults Living Independently In Ireland, Oonagh C. Lyons, Mary A.T. Flynn, Clare A. Corish, Eileen R. Gibney, Maeve A. Kerr, Malachi J. Mckenna, Helene Mcnulty, Emeir M. Mcsorley, Anne P. Nugent, Claire O'Brien, Mary Ward, Katherine Younger, Ita Saul

Conference Papers

Older adults (≥65 years) are the fastest growing population group. Thus, ensuring nutritional well-being of the ‘over-65s’ to optimise health is critically important. Older adults represent a diverse population – some are fit and healthy, others are frail and many live with chronic conditions. Up to 78% of older Irish adults living independently are overweight or obese. The present paper describes how these issues were accommodated into the development of food-based dietary guidelines for older adults living independently in Ireland. Food-based dietary guidelines previously established for the general adult population served as the basis for developing more specific recommendations appropriate …

Frequency Of Homologous Recombination Deficiency In A Large Community-Based Cohort Of Epithelial Ovarian Cancer Cases, Nicole M. Kretzer, Fernanda B. Musa, Christopher Darus, Nancy Biery, Roshanthi Weerasinghe, Grace Li, Ann Vita, Shwetha Pindikuri, Amy S. Parrish, Charles W Drescher

All Podium Presentations

Purpose/Background: Homologous recombination deficiency (HRD) is a useful predictor of treatment response in patients with epithelial ovarian cancer (EOC). Reported data on the frequency of HRD in EOC is largely based on analysis of patients treated at academic medical centers or who participated in clinical trials. We sought to characterize the frequency of HRD based on mutations in homologous recombination repair (HRR) genes, genomic instability (GI) and loss of heterozygosity (LOH) scores in a large community-based cohort of EOC patients who received genomic testing in the context of routine clinical care.

Methods: Information including patient demographic, tumor stage and histology …

Disinformation About Mental Health On Tiktok, Dani Graber, Anne Perrotti (Mentor)

Computer & Information Science: Research Experiences for Undergraduates in Disinformation Detection and Analytics

No abstract provided.

"It Will Help Him Wonderfully": Placebo And Meaning Responses In Early Medieval English Medicine, Rebecca Brackmann

Faculty Peer-Reviewed Publications

Many early English medical remedies have been dismissed, even by sympathetic scholars, as “mere placebo,” with the implication that therapeutic benefits to the patient, if any, are thereby insignificant. My article challenges such dismissals of placebo responses in Old English medicine. I draw on current research demonstrating that in certain conditions, a placebo effect, or “meaning response” (to use Daniel Moerman’s term), can have striking success in bringing about healing. I describe contemporary clinical practices shown to enhance patient responses to pharmaceutical treatments both inert and active, and demonstrate that these strategies are also visible in early English medical practice. …

Ada Constitution & Bylaws (2022), American Dental Association

Constitution & Bylaws

The ADA Commons Constitution & Bylaws archival collection comprises printed issues of the American Dental Association's Constitution and Bylaws. The collection also includes the ADA Charter and the ADA Code of Ethics issued 1924-1946.