Medicine and Health Sciences Commons^™

The Effects Of 465nm Blue Light On Sleepiness & Fatigue, Mark E. Childress

DNP Research Projects

Abstract

Background: Exhaustion is now accepted in nursing culture. Staff suffering from sleepiness and fatigue are more likely to commit medical errors and sentinel events. Emergency department nurses have the greatest risk of committing these errors. Currently, there is no relief provided to shift workers beyond a single 30-minute meal break within a 12-hour period. Other researched mitigation strategies have either failed or are unrealistic in this environment.

Local Problem: Emergency Department nurses at Parkridge Medical Center in Chattanooga, TN suffer from chronic sleepiness and fatigue that is exacerbated by shift duration, excessive workload, a stressful environment, and lack of …

Enhancing Hospitalists' Knowledge In Relation To Palliative Care, Herline Raphael

DNP Research Projects

Abstract

Palliative care was not the specialty of many hospitalists; thus, communication was hindered regarding ELC and advanced directives. Despite healthcare utilization in the United States, inadequate treatment of serious illnesses continues due to the lack of provider education and understanding of ELC (palliative and hospice care). Hospitalists are not formally or informally trained to care for patients that need palliative or hospice care. A quantitative, quasi- experimental and qualitative approach was utilized to determine if hospitalists who received educational training on palliative care communication and collaboration improved knowledge, skills, and collaboration when caring for end-of-life or critically ill patients. …

Improving Nutrition Literacy In Primary Care, Kami D. Dykes

DNP Research Projects

Abstract

By the year 2030, nearly one in every two adults will have obesity (Body Mass Index [BMI] ≥30 kg/m².), and one in four adults will have severe obesity (BMI ≥35 kg/m²) (Ward et al., 2019). Equally troubling is that obesity poses a threat to the health of individuals, decreases the quality of life, shortens life expectancy, causes and worsens comorbidities, and increases all- cause mortality (Abdelaal et al., 2017). Studies have shown a link between BMI, nutritional knowledge, and dietary practices. Nutrition literacy is a newer term that refers to the complex relationship between nutrition …

Men’S Pelvic Health Content In Entry-Level Doctor Of Physical Therapy Curricula: A Physical Therapy Clinician Perspective, Shani Johnson Pt, Dscpt, Cmpt, Rachel Anderson Spt, Marissa Hudoba Spt, Adam Fischer Spt, Benjamin Peters Spt

DPT Capstone Posters

Introducation

Pelvic floor musculature is involved in sexual, bowel, and bladder function, organ support, breathing, and load transfer.1 Sixteen percent of males experience pelvic floor dysfunction (PFD).1 Therefore, it is important for physical therapists to adequately screen male patients to identify PFD either for proper treatment or referral to a men’s pelvic health (MPH) provider.

The Academy of Pelvic Health (APH) offers Doctor of Physical Therapy (DPT) curricular guidelines for Women’s Health content, but to date has no published guidelines for MPH.

Objective

The purpose of this study was to gain clinician perspective to assist in the development of DPT …

Vestibulo-Oculomotor Function, Cognitive Abilities, And Symptoms Of Depression In Male Collegiate Football Players, Megan Dowdal-Osborn Pt, Phd, R. Ebersole Spt, A. Spanbauer Spt, D. Turlington Spt, D. Ziehme Spt

DPT Capstone Posters

Introduction

• Background: Collegiate football players experience increased exposure to repetitive head impacts. These subconcussive head impacts can cause vestibulo-oculomotor (VOM) dysfunction, cognitive impairment, and depressive symptomatology_1-4
• Purpose: To determine the prevalence of VOM dysfunction, cognitive impairment, and depressive symptomology in cleared to play football players

Methods

• Participants: 62 male Division II Football players from Concordia University, Saint Paul
• Tests and Measures:
• Dynamic Visual Acuity (DVA)
• Paced Auditory Serial Addition Test (PASAT)
• Near Point Convergence (NPC)
• Centers for Epidemiologic Studies Depression Scale (CES-D)

Results

• Over half (51.6%) of cleared-to-play athletes presented with at least one positive VOM test
• Eight participants …

Practices And Pedagogies: A Qualitative Study Of Lgbtq+ Representation In Physical Therapy, Jeanne Lojovich Pt, Phd, Megan Coyle Spt, Lacie Kramer Spt, Tyrell O'Donnell Spt, Benjamin O'Fallon Spt, Laura Wangsness-Willemsen Phd

DPT Capstone Posters

Introduction

• U.S. LGBTQ+ community represents 4.5% of the total population.₁
• MN LGBTQ+ community represents ~4% of total population.₂
• Unclear what percentage of LGBTQ+ are represented in PT/PTA professions.
• APTA/MNPTA are attempting efforts to improve diversity in PT/PTA professions.₃

Objective

• Aim to understand the successes, barriers, and shared experiences of under-represented who established careers as PTs or PTAs.

Methods

Subjects

• PT/PTA clinicians and students from the LGBTQ+ community

Four Focus Groups

• Recruitment through flyers and PT/PTA programs in MN
• Virtual 90-minute focus groups
• 2-4 participants with 2 PIs and 2 trained students

Data Analysis

• Audio recorded, transcribed and …

Public's Perceptions Of Early Mobility And Exercise In The Hospital And Intensive Care Unit: A Prospective Descriptive Survey, Amy Toonstra Pt, Dpt, Sydney Chelstrom Spt, Emily Ciesynski Spt, Mackenzie Dockendorf Spt, Brandon Hixson Spt

DPT Capstone Posters

Introduction

• 50% Amount of barriers to early mobility related to patient factors₁
• 25% Rate of physical therapy nontreatment or patient refusal₂
• Is lack of knowledge about benefits of activity a cause for these phenomena?

Objective

To evaluate public opinion on importance and safety of early mobility and exercise for individuals in the hospital and intensive care unit (ICU).

Participants

186 adults were recruited at the Minnesota State Fair in the University of Minnesota Driven to Discover Building to participate in the survey.

Methods

• Survey
• Adapted from previous validated survey₃
• 11 items
• 5 point Likert scale
• Established content …

Optimizing Student Retention From Undergraduate To The Dpt Program Within The Same Institution, Lyndsey Vandenberg Pt, Dpt, Edd, Brittany Boss Spt, Kellen Cameron Spt, Lauren Simonson Spt

DPT Capstone Posters

Introduction

University stakeholders such as academic advisors, admissions staff and undergraduate (UG) faculty have the ability to influence student retention from undergraduate to graduate school. The previous groups of this multi-year project identified that there were gaps in knowledge and resources available to these stakeholders. Prospective UG students wanted increased opportunities to interact with CSP DPT faculty and students. UG Faculty and staff desired additional information and resources that they could share with prospective students. The needs assessment that was conducted drove the main goals and products that this project implemented.

Objective

The purpose of this project was to improve …

The Effect Of An Informational Training Video On Parental Changes In Scoring Of The Asq-3, Erin Simunds Pt, Aisha Abdo Spt, Joe Hall Spt, Taylor Schaffer Spt, Jordyn Yourczek Spt

DPT Capstone Posters

Introduction

• Research indicates that parents often raise concerns regarding their child’s development prior to physician recognition of the problem₁
• Parent-reported screening tools can bridge the communication gap between health professionals and parents
• Parental scoring did not significantly correlate with healthcare professionals₂
• This discrepancy may stem from training on scoring and administration of the screening tool

Objective

• This study investigated the effect of an informational training video (ITV) on changing parental scoring of the Ages and Stages Questionnaire, 3rd edition (ASQ-3)

Outcome Measure: ASQ-3

• Standardized developmental screening tool used to test children aged 1-66 months via 21 questionnaires. Test …

Comparing Dominant To Non-Dominant Shoulder Complex Kinematics In Collegiate Volleyball Players, Peter J. Rundquist Pt, Phd, Jacob Brackett Spt, Michael Hensch Spt, Lauren Herland Spt, Erik Monson Spt

DPT Capstone Posters

Introduction

• Mobility and function of the shoulder may impact performance and injury in volleyball.
• Most previous research identifying humerothoracic (HT), glenohumeral (GH), and scapulothoracic (ST) kinematics is limited through measurements with a goniometer or inclinometer.

Objective

• To identify HT, GH, and/or ST differences between DOM and NDOM shoulders of asymptomatic volleyball players.

Participants

• 22 asymptomatic female NCAA Division II volleyball players from Concordia University St. Paul (CSP)

Methods

• Demographics: age, height, weight, player position, injury history within past 5 years, years of participation
• Screen: ROM, MMT, special tests for radiculopathy, scapular dyskinesis, impingement, and instability
• The G4 electromagnetic motion capture …

Assessing The General Public’S Awareness Of The Pharmacological Benefits Of Structured, Prescribed Exercise In The Treatment Of Chronic Disease, Kristin Lefebvre Pt, Phd, Ccs, William Floyd Spt, Christine Lager Spt, Zoey Stewart Spt, Mckenzie Tirrell Spt

DPT Capstone Posters

Introduction

This novel study sought to observe the general public’s beliefs on the comparison between pharmaceuticals and exercise for the management of chronic disease, as is consistent with the ACSM Exercise is Medicine (EIM) initiative. The EIM initiative seeks to establish physical activity as a standard of care alongside more traditional interventions such as pharmacology. Despite the established benefit of exercise, little is known about the general public's awareness of the pharmacological benefits of structured, prescribed exercise in the treatment of chronic disease.

Objective

Exercise can be an effective intervention for chronic disease and in some cases, as effective as …

Mrt Supportive Housing Evaluation: Enrollment In Supportive Housing Results In Significantly Greater Cross-Sector Cost Savings Than “Treatment As Usual”, Center For Human Services Research, University At Albany

Health and Healthcare Services Reports and Research Briefs

The New York State Medicaid Redesign Team (MRT) was created in 2011 to develop a multi-year reform plan to address unprecedented healthcare cost growth and improve healthcare quality. One innovation tested under this Redesign is the investment in supportive housing, or affordable housing paired with supportive services (e.g., on-site case management, referrals to community-based services). High-cost, high-need Medicaid recipients who were homeless, unstably housed, or living in treatment facilities providing a higher level of care than needed were targeted for enrollment. While expensive, this investment was anticipated to improve quality of life and health outcomes for enrolled clients, thus decreasing …

Free Cholesterol Accelerates Aβ Self-Assembly On Membranes At Physiological Concentration, Mohtadin Hashemi, Siddhartha Banerjee, Yuri L. Lyubchenko

Journal Articles: Pharmaceutical Sciences

The effects of membranes on the early-stage aggregation of amyloid β (Aβ) have come to light as potential mechanisms by which neurotoxic species are formed in Alzheimer's disease. We have shown that direct Aβ-membrane interactions dramatically enhance the Aβ aggregation, allowing for oligomer assembly at physiologically low concentrations of the monomer. Membrane composition is also a crucial factor in this process. Our results showed that apart from phospholipids composition, cholesterol in membranes significantly enhances the aggregation kinetics. It has been reported that free cholesterol is present in plaques. Here we report that free cholesterol, along with its presence inside the …

School Of Pharmacy Intellectual Property Report, Fy22, Second Quarter Report, Soumyajit Majumdar

U. S. Patents, School of Pharmacy

No abstract provided.

Phytochemical Investigation Of Egyptian Riverhemp: A Potential Source Of Antileukemic Metabolites, Shimaa M. Abdelgawad, Mona H. Hetta, Mohamed A. Ibrahim, Premalatha Balachandran

Faculty and Student Publications

As part of our research group's continuous efforts to find alternative treatments for cancer, the aqueous ethanol extract of Sesbania sesban L. Merr. (SS, Egyptian riverhemp) demonstrated an antileukemic activity against K562 cell line. Bioguided fractionation of SS leaves hydroethanolic extract resulted in the isolation of one new compound (33) named as hederatriol 3-O-β-D-glucuronic acid methyl ester as well as 34 known compounds. Seven compounds ((34), (22), (20), (24), (21), (19), and (35)) showed high antiproliferative effects (IC50 = 22.3, 30.8, 31.3, 33.7, 36.6, 37.5, and 41.5 μM, respectively), while four compounds ((32), (5), (29), and (1)) showed milder activities …

Cryptococcosis In A Patient With Multiple Myeloma Receiving Pomalidomide: A Case Report And Literature Review, Daniel B. Chastain, Sahand Golpayegany, Andrés F. Henao-Martínez, Brittany T. Jackson

Faculty and Student Publications

While overall survival with multiple myeloma (MM) has improved, patients suffer from overwhelming tumor burden, MM-associated comorbidities, and frequent relapses requiring administration of salvage therapies. As a result, this vicious cycle is often characterized by cumulative immunodeficiency stemming from a combination of disease- and treatment-related factors leading to neutropenia, T-cell deficiency, and hypogammaglobulinemia. Infectious etiologies differ based on the duration of MM and treatment-related factors, such as number of previous treatments and cumulative dose of corticosteroids. Herein, we present the case of a patient who was receiving pomalidomide without concomitant corticosteroids for MM and was later found to have cryptococcosis, …

Age-Related Neuroendocrine, Cognitive, And Behavioral Co-Morbidities Are Promoted By Hiv-1 Tat Expression In Male Mice, Alaa N. Qrareya, Fakhri Mahdi, Marc J. Kaufman, Nicole M. Ashpole

Faculty and Student Publications

In the U.S. about half of the HIV-infected individuals are aged 50 and older. In men living with HIV, secondary hypogonadism is common and occurs earlier than in seronegative men, and its prevalence increases with age. While the mechanisms(s) are unknown, the HIV-1 trans-activator of transcription (Tat) protein disrupts neuroendocrine function in mice partly by dysregulating mitochondria and neurosteroidogenesis. We hypothesized that conditional Tat expression in middle-aged male transgenic mice [Tat(+)] would promote age-related comorbidities compared to age-matched controls [Tat(−)]. We expected Tat to alter steroid hormone milieu consistent with behavioral deficits. Middle-aged Tat(+) mice had lower circulating testosterone and …

Synthesis Of 3,4,5-Trisubstituted Isoxazoles In Water Via A [3 + 2]-Cycloaddition Of Nitrile Oxides And 1,3-Diketones, Β-Ketoesters, Or Β-Ketoamides, Md Imran Hossain, Md Imdadul H. Khan, Seong Jong Kim, Hoang V. Le

Faculty and Student Publications

Herein we report a method for the synthesis of 3,4,5-trisubstituted isoxazoles in water under mild basic conditions at room temperature via a [3 + 2]-cycloaddition of nitrile oxides and 1,3-diketones, β-ketoesters, or β-ketoamides. We optimized the reaction conditions to control the selectivity of the production of isoxazoles and circumvent other competing reactions, such as O-imidoylation or hetero [3 + 2]-cycloaddition. The reaction happens fast in water and completes within 1-2 hours, which provides an environmentally friendly access to 3,4,5-trisubstituted isoxazoles, an important class of structures found in numerous bioactive natural products and pharmaceuticals. Additionally, we optimized the reaction conditions to …

Identification Of An Orally Bioavailable, Brain-Penetrant Compound With Selectivity For The Cannabinoid Type 2 Receptor, Meirambek Ospanov, Suresh P. Sulochana, Jason J. Paris, John M. Rimoldi

Faculty and Student Publications

Modulation of the endocannabinoid system (ECS) is of great interest for its therapeutic relevance in several pathophysiological processes. The CB2 subtype is largely localized to immune effectors, including microglia within the central nervous system, where it promotes anti-inflammation. Recently, a rational drug design toward precise modulation of the CB2 active site revealed the novelty of Pyrrolo[2,1-c][1,4]benzodiazepines tricyclic chemotype with a high conformational similarity in comparison to the existing leads. These compounds are structurally unique, confirming their chemo-type novelty. In our continuing search for new chemotypes as selective CB2 regulatory molecules, following SAR approaches, a total of 17 selected (S,E)-11-[2-(arylmethylene)hydrazono]-PBD analogs …

1,2,3-Triazole Derivatives As Highly Selective Cannabinoid Receptor Type 2 (Cb2) Agonists, Amer H. Tarawneh, Pankaj Pandey, Lo'ay A. Al-Momani, Anastassiya V. Gadetskaya

Faculty and Student Publications

The cannabinoid receptor 2 (CB2 receptor) has attracted considerable interest, mainly due to its potential as a target for therapeutics for treating various diseases that have a neuroinflammatory or neurodegenerative component while avoiding the adverse psychotropic effects that accompany CB1 receptor-based therapies. With the appreciation that CB2-selective ligands show marked functional selectivity, there is a renewed opportunity to explore this promising area of research from both a mechanistic as well as a therapeutic perspective. In this research, we are interested in the discovery of new chemotypes as highly selective CB2 modulators, which may serve as good starting points for further …

Dual Drug Loaded Lipid Nanocarrier Formulations For Topical Ocular Applications, Ahmed Adel Ali Youssef, Narendar Dudhipala, Soumyajit Majumdar

Faculty and Student Publications

Introduction: Untreated ocular infections can damage the unique fine structures of the eye with possible visual impairments and blindness. Ciprofloxacin (CIP) ophthalmic solution is prescribed as first-line therapy in ocular bacterial infections. Natamycin (NT) ophthalmic suspension is one of the progenitors in ocular antifungal therapy. Nanostructured lipid carriers (NLCs) have been widely examined for ocular penetration enhancement and distribution to deeper ocular tissues. The objective of the current study was to prepare NLCs loaded with a combination of CIP and NT (CIP-NT-NLCs) and embed them in an in-situ gelling system (CIP-NT-NLCs-IG). This novel formulation will target the co-delivery of CIP …

Detroit Food Metrics Report 2020 (With 2021 Update), Alex B. Hill, Amy Kuras

Urban Studies and Planning Faculty Research Publications

This report provides a snapshot of data and information on Detroit’s food system as well as trends over time. The report includes a broad range of programs and initiatives that local organizations, the Detroit Food Policy Council, and the City of Detroit are undertaking to address food insecurity, increase healthy food access and awareness, and support a more sustainable and just food system.

Causal Attribution, Personal Responsibility, And Regret In Lung Cancer Survivors, Justin Ulland, Anthony Cortez-Morales, Kevin R. Criswell

2022 Symposium

Introduction: Lung cancer is the second-most common cancer for males and females and the leading cause of cancer-related deaths in the United States. Ninety percent of lung cancer cases are associated with a smoking history. Less is known about (a) how lung cancer survivors with and without smoking histories attribute their cancer to secondhand smoke and (b) how those attributions may be associated with personal responsibility, regret, and stigma from medical staff/professionals. This secondary data analytic study examined 196 lung cancer survivors.

Method: Paper surveys included (a) whether secondhand smoking caused their cancer, (b) whether they perceived control …

Complete Health Improvement Program To Implement Lifestyle Medicine, Robert Hobbs Jr

Doctor of Nursing Practice Projects

The health of many Americans continues to worsen. Over the past 20 years there has been a fifty percent increase in the incidence of Type 2 Diabetes Mellitus in the US. America has an increase in obesity rates, and lower mortality rates compared to other countries that spend less per capita. Currently the US healthcare system only contributes about 20% of the overall care of patients. Provider burned out is increasing and many remain uneducated regarding lifestyle medicine. Since up to 90% of chronic diseases are lifestyle related, a different approach to chronic disease care is needed. The Complete Health …

Decreasing Falls: Communicating Safety With Patient-Directed Visual Cues, Signs, And Symbols, Lizelle Hill

Doctor of Nursing Practice Projects

Patient falls during hospitalization are a major clinical problem that occurs frequently. It is estimated that between 700,000 and 1,000,000 patients fall in hospitals each year. Between 30% and 50% of patients who fall in hospitals are injured. Consequently, falls with serious injury are among the most frequent hospital-reported sentinel events. Hospitals also suffer from patient falls as the Centers for Medicare and Medicaid Services no longer reimburse for costs related to preventable falls or fall-related injuries. Given the significant negative impact of falls on patients and healthcare organizations, hospitals continue to look for interventions to decrease falls. Research strongly …

Online Support For Families Affected By Opioid Use Disorder, Sharonda Hill

Doctor of Nursing Practice Projects

Families who care for children with neonatal abstinence syndrome (NAS) face many challenges and may be lacking support. The purpose of this project was to provide evidence-based information to families caring for NAS children through an established online support group, To the Moon and Back. Nola Pender’s Health Promotion Model was the theoretical model used to guide this project. An intervention to deliver support and information was implemented through three sessions. During these sessions participants were educated on evidenced-based tools to help their children with behavioral self- regulation and communication with providers. Data was collected through pre and post assessments …

Use Of Academic Detailing To Improve Reporting Of Peri-Operative Events, Allyn Sara Miller-James

Doctor of Nursing Practice Projects

Problem: Four million people worldwide die within thirty days of surgery. The EPIC Corporation has created the opportunity to collect and analyze data on the peri-operative care of patients. Initially, implementation of the program has identified barriers to event reporting by anesthesia providers. Barriers identified in the literature and in semi-structured interviews are fear of liability and retribution by patients, employers, and governing bodies. Significance: Despite national efforts to increase the reporting of medical errors, they remain grossly under- reported. The integration of the National Anesthesia Clinical Outcomes Registry (NACOR) events data collection tool into the EHR for anesthesia providers …

Simulation To Improve Dementia-Related Care Of Veterans, Brandy Wardrip

Doctor of Nursing Practice Projects

Millions of Americans, including Veterans, are diagnosed with dementia. Healthcare staff may benefit from dementia-related training. This Doctorate in Nursing Practice (DNP) project evaluated the effectiveness of the Virtual Dementia Tour (VDT) as a learning tool to improve staff’s knowledge of dementia, enhance their empathy and attitudes when interacting with Veterans diagnosed with the disease, and increase awareness that behaviors commonly seen with dementia may be forms of communication. Interprofessional healthcare staff (N=33) at a Veterans hospital participated in the experiential simulation. A pre-and post-test design utilized the Dementia Knowledge Assessment Scale (DKAS) and the Dementia Attitude Scale …

Providing Mbsr Tools To First Year Adn Nursing Students: A Dnp Project, Katherin Brandt

Doctor of Nursing Practice Projects

Abstract

As part of the educational training provided to nursing students it is important to not only provide information regarding stress management, but also to give them tools that they can use to handle stressful situations more effectively. Literature supports the use of mindfulness techniques practiced regularly to decrease stress and anxiety. This DNP project developed, implemented, and evaluated the addition of Mindfulness-Based Stress Reduction (MBSR) techniques into the curriculum of the first-year Medical Surgical nursing course in a prelicensure Associate Degree Nursing program. The project was guided by Watson’s Theory of Human Caring and the Model for Improvement (PDSA …

Streamlining The Referral Process For A Mental Health Clinic: A Dnp Project, Ashley Barr

Doctor of Nursing Practice Projects

Abstract

Mental health providers are in short supply in the United States. Access to mental health is impacted by the process used to refer patients. To bridge this gap, this DNP Project sought to increase mental health referrals to the partnering organization through strategic outreach to primary care and an online social media presence. After IRB approval, outreach to twenty-one primary care providers across eleven clinics was completed, a social media campaign was conducted, and the intake form for the partnering organization was updated for tracking the source of the referral. Results of the interventions included high satisfaction on the …