Medicine and Health Sciences Commons^™

2022-02-09_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …

Tactical Masters Athletes: Bmi Index Classifications, Marc Keefer, Joe Walsh, Kent Adams, Mike Climstein, Chad Harris, Mark Debeliso

All Faculty Scholarship for the College of Education and Professional Studies

Understanding the nexus between aging, physical activity, and obesity has been a source of ongoing investigation. A considerable amount of research has focused on Masters athletes in this regard, suggesting a beneficial relationship between Masters sport participation and a healthy body mass index (BMI). Some consider Active Duty military personnel as tactical athletes. As such, it is of interest to determine if aging Active Duty military personnel (or Masters Tactical Athletes) might have a similar BMI as other Masters athletes (MA). As such, this investigation examined previously recorded data of Active Duty Enlisted United States Marines (n = 402, male, …

Differences In Clinical And Functional Outcomes Between Osteochondral Allograft Transplantation And Autologous Chondrocyte Implantation For The Treatment Of Focal Articular Cartilage Defects, John R Matthews, Joseph Brutico, Daniel Abraham, Jeremy Heard, Bradford Tucker, Fotios Tjoumakaris, Kevin Freedman

Rothman Institute Papers

Background: Articular cartilage pathology can result from a spectrum of origins, including trauma, osteochondritis dissecans, avascular necrosis, or degenerative joint disease.

Purpose: To compare the differences in clinical and patient-reported outcomes after autologous chondrocyte implantation (ACI) versus osteochondral allograft transplantation (OCA) in patients with focal articular cartilage defects without underlying bone loss.

Study design: Cohort study; Level of evidence, 3.

Methods: A retrospective review identified patients who underwent ACI or OCA between 2008 and 2016 for isolated grades 3 and 4 articular cartilage defects without underlying bone loss. Outcome measures included the Knee injury and Osteoarthritis Outcome Score for Joint …

Complexes Of Ghrelin Ghs-R1a, Ghs-R1b, And Dopamine D1 Receptors Localized In The Ventral Tegmental Area As Main Mediators Of The Dopaminergic Effects Of Ghrelin, Gemma Navarro, William Rea, César Quiroz, Estefanía Moreno, Devan Gomez, Cody J. Wenthur, Vicent Casadó, Lorenzo Leggio, Matthew C. Hearing, Sergi Ferré

Biomedical Sciences Faculty Research and Publications

Ghrelin receptor, also known as growth hormone secretagogue receptor (GHS-R1a), is coexpressed with its truncated isoform GHS-R1b, which does not bind ghrelin or signal, but oligomerizes with GHS-R1a, exerting a complex modulatory role that depends on its relative expression. D₁ dopamine receptor (D1R) and D5R constitute the two D₁-like receptor subtypes. Previous studies showed that GHS-R1b also facilitates oligomerization of GHS-R1a with D1R, conferring GHS-R1a distinctive pharmacological properties. Those include a switch in the preferred coupling of GHS-R1a from Gq to Gs and the ability of D1R/D5R agonists and antagonists to counteract GHS-R1a signaling. Activation of ghrelin …

Resistant Starch Type 2 And Whole Grain Maize Flours Enrich Different Intestinal Bacteria And Metatranscriptomes, Zachary A. Bendiks, Justin Guice, Diana Coulon, Anne M. Raggio, Ryan C. Page, Diana G. Carvajal-Aldaz, Meng Luo, David A. Welsh, Brian D. Marx, Christopher M. Taylor, Claudia Husseneder, Michael J. Keenan, Maria L. Marco

School of Medicine Faculty Publications

The intestinal microbiota of Sprague-Dawley (SD) rats were investigated following consumption of diets containing refined high-amylose cornstarch (RS), waxy whole-grain flour from maize (WG), or high-amylose whole-grain flour (WG + RS) together with moderate (MF, 30% of energy) or high (HF, 42% of energy) levels of fat. Compared with control (CON) diets, RS reduced bacterial alpha-diversity and enriched Bacteroidetes and WG increased Lactobacillus proportions by three-fold. WG + RS conferred a combined effect, but the changes were attenuated and greater inter-individual variation was observed. Proportions of fiber-degrading bacterial taxa were inversely correlated with cecal pH. Notably, there was little influence …

Glomerular Biomechanical Stress And Lipid Mediators During Cellular Changes Leading To Chronic Kidney Disease., Mukut Sharma, Vikas Singh, Ram Sharma, Arnav Koul, Ellen T. Mccarthy, Virginia J. Savin, Trupti Joshi, Tarak Srivastava

Manuscripts, Articles, Book Chapters and Other Papers

Hyperfiltration is an important underlying cause of glomerular dysfunction associated with several systemic and intrinsic glomerular conditions leading to chronic kidney disease (CKD). These include obesity, diabetes, hypertension, focal segmental glomerulosclerosis (FSGS), congenital abnormalities and reduced renal mass (low nephron number). Hyperfiltration-associated biomechanical forces directly impact the cell membrane, generating tensile and fluid flow shear stresses in multiple segments of the nephron. Ongoing research suggests these biomechanical forces as the initial mediators of hyperfiltration-induced deterioration of podocyte structure and function leading to their detachment and irreplaceable loss from the glomerular filtration barrier. Membrane lipid-derived polyunsaturated fatty acids (PUFA) and their …

Inclusive, Supportive And Dignified Maternity Care (Sdmc)-Development And Feasibility Assessment Of An Intervention Package For Public Health Systems: A Study Protocol, Bilal Iqbal Avan, Waqas Hameed, Bushra Khan, Muhammad Asim, Sarah Saleem, Sameen Siddiqi

Community Health Sciences

Introduction: Mistreatment, discrimination, and poor psycho-social support during childbirth at health facilities are common in lower- and middle-income countries. Despite a policy directive from the World Health Organisation (WHO), no operational model exists that effectively demonstrates incorporation of these guidelines in routine facility-based maternity services. This early-phase implementation research aims to develop, implement, and test the feasibility of a service-delivery strategy to promote the culture of supportive and dignified maternity care (SDMC) at public health facilities.
Methods: Guided by human-centred design approach, the implementation of this study will be divided into two phases: development of intervention, and implementing and testing …

Functional Maintenance Of Differentiated Embryoid Bodies In Microfluidic Systems: A Platform For Personalized Medicine, Umut A. Gurkan

Faculty Scholarship

Hormone replacement therapies have become important for treating diseases such as premature ovarian failure or menopausal complications. The clinical use of bioidentical hormones might significantly reduce some of the potential risks reportedly associated with the use of synthetic hormones. In the present study, we demonstrate the utility and advantage of a microfluidic chip culture system to enhance the development of personalized, on-demand, treatment modules using embryoid bodies (EBs). Functional EBs cultured on microfluidic chips represent a platform for personalized, patient-specific treatment cassettes that can be cryopreserved until required for treatment. We assessed the viability, differentiation, and functionality of EBs cultured …

Aloin Isoforms (A And B) Selectively Inhibits Proteolytic And Deubiquitinating Activity Of Papain Like Protease (Plpro) Of Sars-Cov-2 In Vitro., Devin S M Lewis, Joanna Ho, Savannah Wills, Anasha Kawall, Avini Sharma, Krishna Chavada, Maximilian C C J C Ebert, Stefania Evoli, Ajay Singh, Srujana Rayalam, Vicky Mody, Shashidharamurthy Taval

PCOM Scholarly Works

The most common host entry point of human adapted coronaviruses (CoV) including SARS-CoV-2 is through the initial colonization in the nostril and mouth region which is responsible for spread of the infection. Most recent studies suggest that the commercially available oral and nasal rinse products are effective in inhibiting the viral replication. However, the anti-viral mechanism of the active ingredients present in the oral rinses have not been studied. In the present study, we have assessed in vitro enzymatic inhibitory activity of active ingredients in the oral mouth rinse products: aloin A and B, chlorhexidine, eucalyptol, hexetidine, menthol, triclosan, methyl …

Lymphoma With Tuberculous Granulomas, Jyoti Mohan Lal, Anila Rashid

Department of Pathology and Laboratory Medicine

Chronic granulomatous inflammation is a common finding in lymphoproliferative disorders (LPDs), but it is important to exclude coexisting mycobacterium tuberculosis (MTB) especially in patients from areas of high endemicity. This case emphasizes the relevance of performing MTB culture on bone marrow exhibiting LPD and concomitant granulomas

Hpg80 (Circulating Progastrin), A Novel Blood-Based Biomarker For Detection Of Poorly Differentiated Neuroendocrine Carcinoma And Well Differentiated Neuroendocrine Tumors, Aman Chauhan, Alexandre Prieur, Jill Kolesar, Susanne Arnold, Léa Payen, Younes Mahi, Berengere Vire, Madison Sands, B. Mark Evers, Dominique Joubert, Lowell Anthony

Markey Cancer Center Faculty Publications

Current blood-based biomarkers for neuroendocrine neoplasms (NENs) lack both sensitivity and specificity. Human circulating progastrin (hPG₈₀) is a novel biomarker that can be easily measured in plasma by ELISA. This study is the first to examine hPG₈₀ in NENs. Plasma hPG₈₀ was quantified from 95 stage IV NEN patients, using DxPG₈₀ technology (ECS Progastrin, Switzerland) and compared with hPG₈₀ concentrations in two cohorts of healthy donor controls aged 50–80 (n = 252) and 18–25 (n = 137). Median hPG₈₀ in NENs patients was 5.54 pM compared to 1.5 pM for the …

Diet Quality And Dietary Inflammatory Index Score Among Women’S Cancer Survivors, Sibylle Kranz, Faten Hasan, Erin Kennedy, Jamie Zoellner, Kristin A. Guertin, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert, Roger Anderson, Wendy Cohn

Faculty Publications

The purpose of this study was to investigate Healthy Eating Index 2015 (HEI-2015) and Energy-Adjusted Dietary Inflammatory Index (E-DIITM) scores in women's cancer survivors and to examine socio-economic (SES) characteristics associated with these two diet indices. In this cross-sectional study, survivors of women's cancers completed a demographic questionnaire and up to three 24-h dietary recalls. HEI-2015 and E-DII scores were calculated from average intakes. One-way ANOVA was used to examine the association of various demographic factors on HEI-2015 and E-DII scores. Pearson Correlation was used to calculate the correlation between the two scores. The average HEI-2015 score was 55.0 +/- …

A Tranquil Virtual Reality Experience To Reduce Subjective Stress Among Covid-19 Frontline Healthcare Workers., Elizabeth Beverly, Laurie Hommema, Kara Coates, Gary Duncan, Brad Gable, Thomas Gutman, Matthew Love, Carrie Love, Michelle Pershing, Nancy Stevens

Medical Education Articles

OBJECTIVE: The novel coronavirus-19 (COVID-19) has taken an immense physical, social, and emotional toll on frontline healthcare workers. Research has documented higher levels of anxiety, depression, and burnout among healthcare workers during the pandemic. Thus, creative interventions are needed now more than ever to provide brief, accessible support to frontline workers. Virtual reality is a rapidly growing technology with potential psychological applications. In this study, we piloted a three-minute Tranquil Cinematic-VR simulation of a nature scene to lower subjective stress among frontline healthcare workers in COVID-19 treatment units. We chose to film a nature scene because of the extensive empirical …

Bridging The Gap To Advance The Care Of Individuals With Cancer: Collaboration And Partnership In The Cardiology Oncology Innovation Network (Coin), Sherry-Ann Brown, Craig Beavers, Hugo R Martinez, Catherine H Marshall, Iredia M Olaye, Avirup Guha, David Cho, Alison Bailey, Carmen Bergom, Neha Bansal, Brenton Bauer, Richard K Cheng

2020-Current year OA Pubs

Cardiovascular diseases and cancer continue to be the two leading causes of death in the United States. While innovations in artificial intelligence, digital health, and telemedicine may revolutionize cardio-oncology clinical practice, barriers to widespread adoption continue to exist. The most effective way to advance these technologies is through a broad range of stakeholders sharing a common vision. Additionally, as we enter the digital era in healthcare, we must help lead this charge for the benefit of our cardiology and oncology patients. Bolstering collaborations in cardiology and oncology is key, in partnership with technology firms, industry, academia, and private practice, with …

Implantable Devices For The Treatment Of Breast Cancer, Mohammad Mohtasim H Pial, Asahi Tomitaka, Nezih Pala, Upal Roy

Health & Biomedical Sciences Faculty Publications

Breast cancer is one of the leading causes of death in the female population worldwide. Standard treatments such as chemotherapy show noticeable results. However, along with killing cancer cells, it causes systemic toxicity and apoptosis of the nearby healthy cells, therefore patients must endure side effects during the treatment process. Implantable drug delivery devices that enhance therapeutic efficacy by allowing localized therapy with programmed or controlled drug release can overcome the shortcomings of conventional treatments. An implantable device can be composed of biopolymer materials, nanocomposite materials, or a combination of both. This review summarizes the recent research and current state-of-the …

Depletion Of The Apical Endosome In Response To Viruses And Bacterial Toxins Provides Cell-Autonomous Host Defense At Mucosal Surfaces, Keiko Maeda, Nicholas C Zachos, Megan H Orzalli, Stefanie S Schmieder, Denis Chang, Katlynn Bugda Gwilt, Michele Doucet, Nicholas W Baetz, Sun Lee, Sue E Crawford, Mary K Estes, Jonathan C Kagan, Jerrold R Turner, Wayne I Lencer

Faculty, Staff and Students Publications

Polarized epithelial cells form an essential barrier against infection at mucosal surfaces. Many pathogens breach this barrier to cause disease, often by co-opting cellular endocytosis mechanisms to enter the cell through the lumenal (apical) cell surface. We recently discovered that the loss of the cell polarity gene PARD6B selectively diminishes apical endosome function. Here, we find that in response to the entry of certain viruses and bacterial toxins into the epithelial cells via the apical membrane, PARD6B and aPKC, two components of the PARD6B-aPKC-Cdc42 apical polarity complex, undergo rapid proteasome-dependent degradation. The perturbation of apical membrane glycosphingolipids by toxin- or …

Disseminated Infection Due To Neocosmospora (Fusarium) Falciformis In A Patient With Acute Myelogenous Leukemia, Ra'ed Jabr, Rachael M Liesman, Venkata Rakesh Sethapati, D Matthew Shoemaker, Andrej Spec, Wissam El Atrouni

2020-Current year OA Pubs

No abstract provided.

Generalized Estimating Equations (Gee) Approach For Clustered Binary Data With Application To Covid-19 Treatment., Sadixa Sanjel

SDSU Data Science Symposium

Clustered binary data frequently occur in epidemiology and other applied fields such as clinical trial studies, where observations within the respective samples are correlated. In such situations, the standard logistic regression method is not valid as logistic regression requires the observations to be independent of one other. This situation arises when treating COVD-19 patients. Patients from certain clusters, such as geographic areas or the same family, are highly correlated, and we need to fit the model using the GEE approach. In this paper, Standard Logistic Regression (LS), Generalized Linear Models (GENMOD), and GEE procedures have been utilized for comparison purposes. …

General Adversarial Networks In Tumor-Related Research: A Review And Agenda For Moving Forward, Andrew James Behrens, Cherie Noteboom

SDSU Data Science Symposium

Recent advances in Generative Adversarial Networks (GANs) have led to many new variants and uses of GANs. The latest advancements have allowed researchers and practitioners to apply this technique to tumor-related problems with limited data. One of the trends in this problem domain is to develop different variants of GANs suited explicitly to particular problems. The variants of GANs are numerous but share a common characteristic of expanding the dataset by creating synthetic data from the original dataset. This paper aims to develop a research agenda through a systematic literature review that investigates practitioners' and researchers' emerging issues and current …

Correlation Analysis Of The Integral Preparedness Of 12-17 Years-Old Gymnasts, Bakhrom Bakhtiyorovich Musaev, Mars Narzievich Umarov

Eurasian Journal of Sport Science

Purpose: Consider a mathematical model of correlation and factor analysis of the readiness of promising young gymnasts and the level of its significance in determining the model characteristics of young athletes

Methods: In this work, methods of mathematical statistics were used, in particular, correlation and factor analysis of the results.

Results: The validity of individual tests changes with age, both with the result in the types of gymnastic all-around, and with the volume of mastered and included in the combination of elements of the highest difficulty group. It turned out to be quite difficult to choose which test is more …

Bladder Tumor In A Young Leukemic Patient Cured By Chemotherapy: A Case Report, Mohamed Tebaa, Mamoutou Dit Mody, Sylla Mahamadou, Mohamed Amine Lakmichi

Health Sciences

Adult bladder tumor is estimated to be the 10th most common tumor worldwide. However, its incidence is much less common in children. It is a disease of the elderly that peaks in the sixth decade of life. Nevertheless, bladder tumors could also affect children, adolescents, and young adults with a prevalence of

Selective Elimination Of Pluripotent Stem Cells By Pikfyve Specific Inhibitors., Arup R Chakraborty, Alex Vassilev, Sushil K Jaiswal, Constandina E O'Connell, John F Ahrens, Barbara S Mallon, Martin Pera, Melvin L Depamphilis

Faculty Research 2022

Inhibition of PIKfyve phosphoinositide kinase selectively kills autophagy-dependent cancer cells by disrupting lysosome homeostasis. Here, we show that PIKfyve inhibitors can also selectively eliminate pluripotent embryonal carcinoma cells (ECCs), embryonic stem cells, and induced pluripotent stem cells under conditions where differentiated cells remain viable. PIKfyve inhibitors prevented lysosome fission, induced autophagosome accumulation, and reduced cell proliferation in both pluripotent and differentiated cells, but they induced death only in pluripotent cells. The ability of PIKfyve inhibitors to distinguish between pluripotent and differentiated cells was confirmed with xenografts derived from ECCs. Pretreatment of ECCs with the PIKfyve specific inhibitor WX8 suppressed their …

Life During The Covid-19 Pandemic Was, And Still Is, Dispiriting, Anonymous

Community Reflections

For me personally, I did not enjoy quarantining at all. I did enjoy seeing my family every day, however, I was very lonely. I couldn’t see any of my friends, which was very disappointing. Thankfully with social media I could facetime them and text them, but face-to-face contact with other people is very necessary; it is something you wouldn’t normally think is important, but when you are unable to physically be with other people, you realize how lonely you feel.

2022-02-08_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …

Specificity Matters: Unpacking Impact Pathways Of Individual Interventions Within Bundled Packages Helps Interpret The Limited Impacts Of A Maternal Nutrition Intervention In India, Shivani Kachwaha, Phuong H. Nguyen, Lan Mai Tran, Rasmi Avula, Melissa F. Young, Sebanti Ghosh, Thomas Forissier, Jessica Escobar-Alegria, Praveen Kumar Sharma, Edward A. Frongillo Jr., Purnima Menon

Faculty Publications

BACKGROUND: To address gaps in coverage and quality of nutrition services, Alive & Thrive (A&T) strengthened the delivery of maternal nutrition interventions through government antenatal care (ANC) services in Uttar Pradesh, India. The impact evaluation of the A&T interventions compared intensive ANC (I-ANC) with standard ANC (S-ANC) areas and found modest impacts on micronutrient supplementation, dietary diversity, and weight-gain monitoring. OBJECTIVES: This study examined intervention-specific program impact pathways (PIPs) and identified reasons for limited impacts of the A&T maternal nutrition intervention package. METHODS: We used mixed methods: frontline worker (FLW) surveys (n = ∼500), counseling observations (n = 407), and …

An Inkjet Printed Flexible Electrocorticography (Ecog) Microelectrode Array On A Thin Parylene-C Film, Yoontae Kim, Stella Alimperti, Paul Choi, Moses Noh

Electrical and Computer Engineering Faculty Publications

Electrocorticography (ECoG) is a conventional, invasive technique for recording brain signals from the cortical surface using an array of electrodes. In this study, we developed a highly flexible 22-channel ECoG microelectrode array on a thin Parylene film using novel fabrication techniques. Narrow (<40 >µm) and thin (<500 >nm) microelectrode patterns were first printed on PDMS, then the patterns were transferred onto Parylene films via vapor deposition and peeling. A custom-designed, 3D-printed connector was built and assembled with the Parylene-based flexible ECoG microelectrode array without soldering. The impedance of the assembled ECoG electrode array was measured in vitro by electrochemical impedance …

"1,000 Conversations I'D Rather Have Than That One:" A Qualitative Study Of Prescriber Experiences With Opioids And The Impact Of A Prescription Drug Monitoring Program., Jillian Zavodnick, Alexis Wickersham, Alison Petok, Brooke Worster, Amy Leader

Department of Medicine Faculty Papers

BACKGROUND: Prescription Drug Monitoring Programs (PDMPs) have shown impacts on a number of opioid-related outcomes but their role in clinician emotional experience of opioid prescribing has not been studied.

OBJECTIVES: This study explores the impact of PDMPs on clinician attitudes toward and comfort with opioid prescribing, their satisfaction with patient interactions involving discussion of opioid prescriptions, and their recognition of opioid use disorder (OUD) and ability to refer patients to treatment.

METHODS: Researchers conducted semi-structured interviews with five physicians and two nurse practitioners from a variety of specialties and practice environments.

RESULTS: Many participants reported negative emotions surrounding opioid-related patient …

03-08-2022 Hsc Committee Notice, Hcs Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

The Effect Of Voice Demand On The Perception Of Voice In Collegiate Athletic Coaches, Olivia Faith Metzgar

Student Theses and Dissertations

This investigation was conducted to investigate the effect of voice demand on the perception of voice in collegiate athletic coaches. This investigation also examined the prevalence of self-perceived voice disorders within collegiate athletic coaches. This study was conducted by distributing a survey to the Division I athletic coaches in the state of Arkansas. The survey consisted of demographic questions and a questionnaire that explored the self-perceived vocal symptoms that were experienced during the current season of coaching. The data collected revealed that there were vocal symptoms that were identified as an effect of occupational voice demand during the current season …

The Effects Of A Carbohydrate Mouth Rinse On Soccer-Specific Skills Following A Morning High-Intensity Practice, Lynnsey Rose Bowling

Student Theses and Dissertations

Carbohydrate mouth rinse (CMR) enhances aerobic performance lasting ≥ 30 minutes and some anaerobic and skill-related performance. This study evaluated the effects of a CMR on four soccer-specific skills in fasted collegiate female athletes. Participants completed a control session and two counterbalanced, double-blind experimental sessions, during which participants rinsed with either a carbohydrate (CHO; 6% maltodextrin) or taste- and color-matched placebo (PLA) solution following a high-intensity soccer practice. Participants then performed passing, agility, juggling, and shooting tasks. Thirst sensation, rating of perceived exertion, and heart rate (HR) were assessed throughout sessions. No significant differences (p >.05) were observed between experimental …