Medicine and Health Sciences Commons^™

Counterfactual Analysis Of Differential Comorbidity Risk Factors In Alzheimer’S Disease And Related Dementias, Yejin Kim, Kai Zhang, Sean I Savitz, Luyao Chen, Paul E Schulz, Xiaoqian Jiang

Faculty, Staff and Student Publications

Alzheimer’s disease and related dementias (ADRD) is a multifactorial disease that involves several different etiologic mechanisms with various comorbidities. There is also significant heterogeneity in the prevalence of ADRD across diverse demographics groups. Association studies on such heterogeneous comorbidity risk factors are limited in their ability to determine causation. We aim to compare counterfactual treatment effects of various comorbidity in ADRD in different racial groups (African Americans and Caucasians). We used 138,026 ADRD and 1:1 matched older adults without ADRD from nationwide electronic health records, which extensively cover a large population’s long medical history in breadth. We matched African Americans …

Factors That Influence Puerto Rican's Intention To Get The Covid-19 Vaccine, Page D. Dobbs, Emily Hermann, Charlie Vidal, Daniela Ameijeiras Mena, Ches Jones

Health, Human Performance and Recreation Faculty Publications and Presentations

Despite Latino Americans having been found to be disproportionally affected by COVID-19, they report higher hesi-tancy to receive the COVID-19 vaccine than non-Hispanic whites. The purpose of this study was to examine factors that influence Puerto Rican's intentions to get the COVID-19 Vaccine. A sample (n = 173) of people who currently lived in Puerto Rico were recruited to complete an online, cross-sectional survey about their intention to receive the COVID-19 vaccine. Demographics and vaccine hesitancy were assessed, and logistic regressions explored relationships between variables and intention to get the COVID-19 vaccine when it became available. When controlling for covar-iates, …

Travel Ban Effects On Sars-Cov-2 Transmission Lineages In The Uae As Inferred By Genomic Epidemiology, Andreas Henschel, Samuel F. Feng, Rifat A. Hamoudi, Gihan Daw Elbait, Ernesto Damiani, Fathimathuz Waasia, Guan K. Tay, Bassam H. Mahboub, Maimunah Hemayet Uddin, Juan Acuna, Eman Alefishat, Rabih Halwani, Herbert F. Jelinek, Farah Mustafa, Nawal Alkaabi, Habiba S. Alsafar

Research outputs 2022 to 2026

Global and local whole genome sequencing of SARS-CoV-2 enables the tracing of domestic and international transmissions. We sequenced Viral RNA from 37 sampled Covid-19 patients with RT-PCR-confirmed infections across the UAE and developed time-resolved phylogenies with 69 local and 3,894 global genome sequences. Furthermore, we investigated specific clades associated with the UAE cohort and, their global diversity, introduction events and inferred domestic and international virus transmissions between January and June 2020. The study comprehensively characterized the genomic aspects of the virus and its spread within the UAE and identified that the prevalence shift of the D614G mutation was due to …

Effects Of St713 With Simultaneous Histamine H3 And Dopamine D2/D3 Receptor Antagonist Properties On Cognitive Impairments And Autism-Like Behaviors In Btbr T+Tf/J Mice, Mohammed Mustafa Alawad

Theses

Autism spectrum disorders (ASD) is a multifactorial neurodevelopmental disorder characterized by two core symptoms which are impairments in social interaction and communication, repetitive and restricted behaviors. Dopamine (DA) and histamine (HA) are two neurotransmitters that are proposed to be involved in several brain disorders including schizophrenia, depression, anxiety, and narcolepsy, all of those disorders are comorbid with ASD. Thus, the palliative effects of the novel multiple-active histamine H3 receptor (H3R) antagonist and dopamine D2/D3 receptor (D2/D3R) antagonist ST-713 with its high H3R antagonist affinity and balanced inhibitory effects on both dopaminergic receptor subtypes D2R and D3R on ASD-like behaviors in …

Vitamin D Deficiency And Its Associated Factors Among Female Migrants In The United Arab Emirates, Fatme Al Anouti, Luai A. Ahmed, Azmat Riaz, William B. Grant, Nadir Shah, Raghib Ali, Juma Alkaabi, Syed M. Shah

All Works

Vitamin D is important for bone health, and vitamin D deficiency could be linked to noncommunicable diseases, including cardiovascular disease. The purpose of this study was to determine the prevalence of vitamin D deficiency and its associated risk factors among female migrants from Philippines, Arab, and South Asian countries residing in the United Arab Emirates (UAE). We used a cross-sectional study to recruit a random sample (N = 550) of female migrants aged 18 years and over in the city of Al Ain, UAE. Vitamin D deficiency was defined as serum 25-hydroxyvitamin D concentrations ≤20 ng/mL (50 nmol/L). We used …

Vitamin D Supplementation And Sleep: A Systematic Review And Meta-Analysis Of Intervention Studies, Myriam Abboud

All Works

Background: Vitamin D deficiency is associated with sleep disorders and poor sleep quality. Whether vitamin D supplementation (VDS) helps resolve these problems remains unclear. Objective: To systematically review the effect of VDS on sleep quantity, quality, and disorders, and perform a meta-analysis of available data. Methods: The reporting of this review followed the PRISMA statement. VDS human interventions studies that reported on sleep quality, quantity, or disorders were included. Medline, CINAHL, EMBASE, PsycInfo, the Cochrane Library, Clinicaltrials.gov, and the ICTRP were searched, in addition to the references of the included articles and previous relevant reviews, without language or time restrictions. …

Special Education Teacher Burnout: Examining The Role Of Educator Preparation Programs In Prevention, Brittany L. Straub

Dissertations

Teacher burnout is increasingly problematic, especially for special education teachers who have a unique set of job responsibilities. Survey and interview data was used in this phenomenological study to examine how the educator preparation program (EPP) experience and self-authorship journey of early career special education teachers impact their potential to experience burnout. Data findings regarding level of self-perceived burnout, recollections of being or not being taught stress management and coping strategies in their EPPs, recollections of the self-authorship journey, and intentions for remaining in the career are shared in this dissertation. The essence of this phenomenon can be summed up …

A Step Forward For Patients In The Icu: An Integrative Review Of Early Mobility Interventions And Associated Outcome Measures, Christina Bach

Posters and Presentations: College of Nursing

No abstract provided.

Delirium Associations With Antibiotics: A Pharmacovigilance Study Of The Fda Adverse Event Reporting System (Faers), Chengwen Teng, Christopher R. Frei

Faculty Publications

Background Ertapenem, cefepime, imipenem, ofloxacin, ceftazidime, clarithromycin, cefaclor, levofloxacin, linezolid, moxifloxacin, azithromycin, piperacillin-tazobactam, trimethoprim-sulfamethoxazole, metronidazole, ciprofloxacin, and cefuroxime are known to be associated with delirium. Other antibiotics may also lead to delirium, but no study has systemically compared delirium associations for many available antibiotics.

Objective The objective of this study was to evaluate the association between delirium and antibiotics using the FDA Adverse Event Reporting System (FAERS).

Methods FAERS reports from January 1, 2004 to December 31, 2018 were included in the study. Reporting odds ratios (RORs) and corresponding 95% confidence intervals (95% CI) for the association between antibiotics and …

Naltrexone Implant For Opioid Use Disorder, Amber N. Edinoff, Catherine A. Nix, Claudia V. Orellana, Samantha M. Stpierre, Erin A. Crane, Blaine T. Bulloch, Elyse M. Cornett, Rachel L. Kozinn, Adam M. Kaye, Kevin S. Murnane, Alan David Kaye

School of Pharmacy Faculty Articles

The continued rise in the availability of illicit opioids and opioid-related deaths in the United States has left physicians, researchers, and lawmakers desperate for solutions to this ongoing epidemic. The research into therapeutic options for the treatment of opioid use disorder (OUD) began with the introduction of methadone in the 1960s. The approval of oral naltrexone initially showed much promise, as the drug was observed to be highly potent in antagonizing the effects of opioids while producing no opioid agonist effects of its own and having a favorable side effect profile. Patients that routinely take their naltrexone reported fewer days …

The Scoop, Vol. 8 Issue 12, March 2022, Health Sciences Library

Volume 8

Latest news and updates from the Health Sciences Library in our monthly newsletter for March 2022.

Inhalation Injury Is Associated With Endotheliopathy And Abnormal Fibrinolytic Phenotypes In Burn Patients: A Cohort Study, John W. Keyloun, Tuan D. Le, Kathleen E. Brummel-Ziedins, Melissa M. Mclawhorn, Maria C. Bravo, Thomas Orfeo, Laura S. Johnson, Lauren T. Moffatt, Anthony E. Pusateri, Jeffrey W. Shupp

School of Medicine Faculty Publications and Presentations

Burn injury is associated with endothelial dysfunction and coagulopathy and concomitant inhalation injury (IHI) increases morbidity and mortality. The aim of this work is to identify associations between IHI, coagulation homeostasis, vascular endothelium, and clinical outcomes in burn patients. One hundred and twelve patients presenting to a regional burn center were included in this retrospective cohort study. Whole blood was collected at set intervals from admission through 24 hours and underwent viscoelastic assay with rapid thromboelastography (rTEG). Syndecan-1 (SDC-1) on admission was quantified by ELISA. Patients were grouped by the presence (n = 28) or absence (n = 84) of …

Effect Of Incorporation Of Bioactive Hydroxyapatite Nano-Rods In Self-Etch Adhesive On Microleakage, Nanoleakage Pattern And Elemental Analysis Of Resin/Dentin Interface, Samaher M. Taha, Hamdi H. Hammama, Salah H. Mahmoud

Mansoura Journal of Dentistry

Objective: To compare the effect of four types of adhesives immediately and after 6 months storage in artificial saliva followed by thermocycling (2000 cycle) on microleakage patterns, the nanoleakage pattern, and elemental analysis of adhesive interface. Materials and Methods: A total of 120 extracted sound human permanent molars were selected. And assigned into 4 groups according to adhesive types (one step-self-etch (1S-SE) adhesive, modified self-etch adhesive with hydroxyapatite nanorods (HA-NR), universal adhesive, resin-modified glass ionomer-based adhesive). Each group was further subdivided into two subgroups according to time of testing, (a) immediately evaluated, (b) was subjected to the 6 months storage …

Immortal Plain Gut Sutures: A Case Report, Hannah J. Anderson, Kathryn Lynn, Raziyeh Mahmoudzadeh, Tatyana Milman, Manish Jain, Sunir J Garg

Wills Eye Hospital Papers

Purpose: We report the case of a 79-year-old male who presented with irritation and foreign body sensation due to the subconjunctival plain gut sutures that did not dissolve three years after undergoing pars plana vitrectomy (PPV) for macular hole repair.

Observation: A 79-year-old male presented with foreign body sensation and irritation in his left eye. On slit lamp examination, the source of the foreign body sensation was two apparently intact plain gut sutures were visible under the conjunctiva, nasal and temporal to the cornea. These plain gut sutures were placed at the conclusion of PPV surgery three years prior to …

Clinical Validation Of A Multiplex Pcr-Based Detection Assay Using Saliva Or Nasopharyngeal Samples For Sars-Cov-2, Influenza A And B, Nikhil S. Sahajpal, Ashis K. Mondal, Sudha Ananth, Allan Njau, Kimya Jones, Pankaj Ahluwalia, Eesha Oza, Ted M. Ross, Vamsi Kota, Arvind Kothandaraman

Pathology, East Africa

The COVID-19 pandemic has resulted in significant diversion of human and material resources to COVID-19 diagnostics, to the extent that influenza viruses and co-infection in COVID-19 patients remains undocumented and pose serious public-health consequences. We optimized and validated a highly sensitive RT-PCR based multiplex-assay for the detection of SARS-CoV-2, influenza A and B viruses in a single-test. This study evaluated clinical specimens (n = 1411), 1019 saliva and 392 nasopharyngeal swab (NPS), tested using two-assays: FDA-EUA approved SARS-CoV-2 assay that targets N and ORF1ab gene, and the PKamp-RT-PCR based assay that targets SARS-CoV-2, influenza viruses A and B. Of the …

A Sacral Filum Terminale Arteriovenous Fistula Fed By A Left T9 Artery Of Adamkiewicz, Kareem El Naamani, Rawad Abbas, Georgios S. Sioutas, Abdelaziz Amllay, Alfredo Munoz, Nabeel Herial, Stavropoula Tjoumakaris, Michael Reid Gooch, James Harrop, Robert H. Rosenwasswer, Pascal Jabbour

Department of Neurosurgery Faculty Papers

This is a case of 62-year-old patient presenting with tingling and numbness extending from the buttocks area towards the lower extremities and gait instability. Contrast Magnetic Resonance Imaging (MRI) and time-resolved imaging of contrast kinetics Magnetic Resonance Imaging (TRICKS MRI) raised suspicion for a possible dural arteriovenous fistula. Diagnostic Digital Subtraction Angiography (DSA) showed a filum terminale arterio venous fistula (AVF) fed by the left T9 from the anterior spinal artery of Adamkiewicz all the way down to the fistulous point at L5-S1. The patient underwent successful laminectomy of L5-S1 and clipping of the filum terminale arteriovenous fistula.

Multisystem Inflammatory Syndrome In Children (Mis-C): Inpatient, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Examination Of Care Processes And Treatment Optimization For Head And Neck Cancer Patients In A Community Setting “Hub And Hub” Model, Harleen K. Sethi, Elijah Walker, Travis Weinsheim, Matthew J. Brennan, Christopher E. Fundakowski

Otolaryngology (ENT) Resident Research

Objective

To examine referral pattern, the timing of diagnostic/staging processes, and treatment initiation for new head and neck cancer patients in a community setting.

Methods

Patients with a newly diagnosed previously untreated diagnosis of head neck cancer managed at Asplundh Cancer Pavilion/Abington Memorial Hospital from October 2018 to March 2020. Source of referral and preceding workup were examined as well as intervals between initial head and neck consult and various timepoints of treatment initiation.

Results

One hundred and five patients were included in the study. The primary referral sources were external general otolaryngology (56.3%). Oral surgery and dermatology obtained tissue …

Exploring Stress Relief Methods And The Efficacy For The Houseless At Urban Settings, Lexis Bates

University Honors Theses

When the word "stress" is mentioned to lay people, they might think that their definitions of "stress" would be the same or similar. However, stress may vary by, not only degrees of the adverse circumstances, but also kinds of stressors which make an individual's experience of stress and their coping mechanisms complicated. Stress refers to a state of mental strain or tension resulting from adverse circumstances. Each individual living in society undergoes stress as a part of life. To some degree, stress keeps us motivated to stay alive in this way through survival instincts. However, excess stress may cause chaos …

American Heart Association Epi|Lifestyle Scientific Sessions: 2021 Meeting Highlights, Ruth Alma Turkson-Ocran, Kathryn Foti, Anika L. Hines, Debora Kamin Mukaz, Hyunju Kim, Samantha Martin, Anum Minhas, Faye L. Norby, Oluwabunmi Ogungbe, Alexander C. Razavi, Mary R. Rooney, Elisabeth L.P. Sattler, Jewel Scott Phd, Rn, Fnp-C, Alvin G. Thomas, Curtis Tilves, Amelia S. Wallace, Frances M. Wang, Mingyu Zhang, Pamela L. Lutsey, Kristie J. Lancaster

Faculty Publications

No abstract provided.

Riding The Wave: Reactive Vector-Borne Disease Policy Renders The United States Vulnerable To Outbreaks And Insecticide Resistance, Kyndall C. Dye-Braumuller, Jennifer R. Gordon, Kaci Mccoy, Danielle Johnson, Rhoel Dinglasan, Melissa Nolan Ph.D., Mph

Faculty Publications

Funding for vector-borne disease surveillance, management, and research is cyclical and reactive in the United States. The subsequent effects have yielded gross inequities nationally that unintentionally support recurrent outbreaks. This policy forum is comprised of four primary subsections that collectively identify specific areas for improvement and offer innovative solutions to address national inadequacies in vector borne disease policy and infrastructure.

The Status And Future Of Emergency Care In The Republic Of Kenya, J. Austin Lee, Grace Wanjiku, Naomi Nduku, Adam R. Aluisio, Ramu Kharel, John Tabu Simiyu, Benjamin Wachira

Emergency Medicine, East Africa

Kenya is a rapidly developing country with a growing economy and evolving health care system. In the decade since the last publication on the state of emergency care in Kenya, significant developments have occurred in the country's approach to emergency care. Importantly, the country decentralized most health care functions to county governments in 2013. Despite the triple burden of traumatic, communicable, and non-communicable diseases, the structure of the health care system in the Republic of Kenya is evolving to adapt to the important role for the care of emergent medical conditions. This report provides a ten-year interval update on the …

If Dentistry's Social Contract With America Could Talk, Chester Gary Dds, Jd

The New York State Dental Journal

Dentistry must make running the business of dental practices compatible with professional responsibility.

New York Continues Employment Law Rampage, Lance Plunkett Jd, Llm

The New York State Dental Journal

Newly enacted laws continue trend favoring employee rights. Dental practices on notice.

Prolonged Glycemic Adaptation Following Transition From A Low- To High-Carbohydrate Diet: A Randomized Controlled Feeding Trial, Lisa T Jansen, Nianlan Yang, Julia M W Wong, Tapan Mehta, David B Allison, David S Ludwig, Cara B Ebbeling

Children’s Nutrition Research Center Staff Publications

Objective: Consuming ≥150 g/day carbohydrate is recommended for 3 days before an oral glucose tolerance test (OGTT) for diabetes diagnosis. For evaluation of this recommendation, time courses of glycemic changes following transition from a very-low-carbohydrate (VLC) to high-carbohydrate diet were assessed with continuous glucose monitoring (CGM).

Research design and methods: After achieving a weight loss target of 15% (±3%) on the run-in VLC diet, participants (18-50 years old, BMI ≥27 kg/m2) were randomly assigned for 10 weeks to one of three isoenergetic diets: VLC (5% carbohydrate and 77% fat); high carbohydrate, high starch (HC-Starch) (57% carbohydrate and 25% fat, including …

Evaluation Of The Type I Error Rate When Using Parametric Bootstrap Analysis Of A Cluster Randomized Controlled Trial With Binary Outcomes And A Small Number Of Clusters, Lilian Golzarri-Arroyo, Stephanie L Dickinson, Yasaman Jamshidi-Naeini, Roger S Zoh, Andrew W Brown, Arthur H Owora, Peng Li, J Michael Oakes, David B Allison

Children’s Nutrition Research Center Staff Publications

Background: Cluster randomized controlled trials (cRCTs) are increasingly used but must be analyzed carefully. We conducted a simulation study to evaluate the validity of a parametric bootstrap (PB) approach with respect to the empirical type I error rate for a cRCT with binary outcomes and a small number of clusters.

Methods: We simulated a case study with a binary (0/1) outcome, four clusters, and 100 subjects per cluster. To compare the validity of the test with respect to error rate, we simulated the same experiment with K=10, 20, and 30 clusters, each with 2,000 simulated datasets. To test the null …

Teen Reactions To A Self-Representational Avatar: A Qualitative Exploration, Emily Baysden, Ninna Mendoza, Chishinga Callender, Zhigang Deng, Debbe Thompson

Children’s Nutrition Research Center Staff Publications

Purpose: This research presents findings from a qualitative exploration of the reactions of adolescents (12-14 years old) to navigating an exergame with an avatar created from multiple scans of the player (referred to as a self-representational avatar).

Methods: Post-gameplay interviews were conducted with adolescents following participation in a 20-min laboratory session (21.2 ± 0.8 min, mean ± SD) where the self-representational avatar was navigated through an exergame. Verbatim transcripts (n = 40) were coded and analyzed by 2 independent coders using hybrid thematic analysis for this secondary data analysis. Codes were reviewed to identify themes representing adolescents' reactions.

Results: Four …

Treatment Of Peri-Implant Soft Tissue Deficiency Around A Narrow Diameter Implant With Subepithelial Connective Tissue Graft: A Case Report, Jaewon Kim Dds, Ms, Phd, Abhiram Maddi Dds Msc Phd

The New York State Dental Journal

Narrow diameter implants and mini-implants are preferred by dentists for restoration of missing teeth on narrow ridges. However, such implants are associated with long-term complications including soft tissue deficiencies. This case report describes a novel approach using a connective tissue graft to resolve peri-implant mucositis. A 66-year old male patient presented with inflammation and abscess in relation to a mini-implant, at the upper left incisor, on the facial aspect. Deficiencies of keratinized tissue and width of attached gingiva were observed. Surgical management was performed using subepithelial connective tissue. An 18-month follow up showed increased width of attached gingiva at the …

Orthognathic Surgery And Quality Of Life Outcomes: Findings From A Hospital-Based Patient Satisfaction Survey, Parth D. Shah Dds, Mph, Victor M. Badner Dmd, Mph, Benn Lieberman Dmd

The New York State Dental Journal

This study examined patient satisfaction and changes in quality of life (QoL) following the orthognathic surgery performed to treat severe dentofacial deformities. The short form of the oral health impact profile (OHIP-14) instrument was utilized to measure the negative impact related to severe dentofacial deformities on QoL. Ninety-five patients participated in this survey. Respondents reported significant reduction in the overall OHIP-14 score following the orthognathic surgery (p-value<0.0001). Approximately 92% reported post-operative resolution of their chief concerns. In conclusion, orthognathic surgery was found beneficial as it significantly reduced the negative impact of severe skeletal malocclusion on QoL of the patient we surveyed.

Simple Lipoma Mimicking Oral Infiltrating Lipoma: Case Report, Moacyr Tadeu V. Rodrigues Dds, Msc, Judson N. Brasil Dds, Gabriel A. Guillen Dds, Msc, Cláudio F. Nóia Dds, Phd

The New York State Dental Journal

Lipomas are common soft tissue neoplasms, usually present in the trunk and proximal portions of the extremities and less frequent in the mouth. We reported the case of a 51-year-old patient, affected by an intra/extra-oral swelling for 8 months. Aspiration, surgical excision and histopathological examination confirmed that it was a simple oral lipoma, although clinically and surgically, it mimicked an infiltrating lipoma. Conservative surgical treatment, preferably by an intra-oral approach provides less morbidity and less sequelae for patients.