Medicine and Health Sciences Commons^™

The Effectiveness Of Functional Training On Static Balance, Dynamic Balance And Flexibility Of Females With Intellectual Disability, Sakineh Farrokhian, Ghorban Hemati Alamdarloo, Enayatollah Asadmanesh

Baltic Journal of Health and Physical Activity

Background: Children with intellectual disability (ID) have less balance and flexibility than typically developing peers. The aim of this study was to determine the effectiveness of functional training on static balance, dynamic balance and flexibility of female students with intellectual disability. Material/Methods: The research method was pre-test – post-test with a control group. The statistical population consisted of all female students with ID in elementary school of Shiraz studying under the auspices of the Special Education Organization in 2018–2019. The participants included 30 female students with ID selected through convenience sampling and randomly assigned to the experimental (n = 15) …

Dynamics Of Changes In Time Differences And Muscle Strength In Qualified Handball Students During The Academic Year, Muminov Abrorbek Shavkatovich

Eurasian Journal of Sport Science

Purpose: It consists in studying during the school year the accuracy of shooting at targets installed in the corners of the gate in a calm position for experienced handball players and in the influence of turning the body in different directions.

Methods: The following methods were used in the course of the study: 1) literary sources, analysis of research papers and scientific articles, scientific research on the topic, scientific and practical experience of foreign and domestic scientists in the field of sports in bund were studied and analyzed. 2) A pedagogical test in which the accuracy of the difference between …

Dynamics Of Changes In Time Differences And Muscle Strength In Qualified Handball Students During The Academic Year, Muminov Abrorbek Shavkatovich

Eurasian Journal of Sport Science

Aim: It consists in studying during the school year the accuracy of shooting at targets installed in the corners of the gate in a calm position for experienced handball players and in the influence of turning the body in different directions.

Methods: The following methods were used in the course of the study: 1) literary sources, analysis of research papers and scientific articles, scientific research on the topic, scientific and practical experience of foreign and domestic scientists in the field of sports in bund were studied and analyzed. 2) A pedagogical test in which the accuracy of the difference between …

2022-03-16_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2022-03-16 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Transcriptional Control Of Retinal Ganglion Cell Death After Axonal Injury., Stephanie B Syc-Mazurek, Hongtian Stanley Yang, Olivia J Marola, Gareth R Howell, Richard T Libby

Faculty Research 2022

Injury to the axons of retinal ganglion cells (RGCs) is a key pathological event in glaucomatous neurodegeneration. The transcription factors JUN (the target of the c-Jun N-terminal kinases, JNKs) and DDIT3/CHOP (a mediator of the endoplasmic reticulum stress response) have been shown to control the majority of proapoptotic signaling after mechanical axonal injury in RGCs and in other models of neurodegeneration. The downstream transcriptional networks controlled by JUN and DDIT3, which are critical for RGC death, however, are not well defined. To determine these networks, RNA was isolated from the retinas of wild-type mice and mice deficient in Jun, Ddit3, …

Adult Mouse Fibroblasts Retain Organ-Specific Transcriptomic Identity., Elvira Forte, Mirana Ramialison, Hieu T Nim, Madison Mara, Jacky Y Li, Rachel Cohn, Sandra Daigle, Sarah Boyd, Edouard G Stanley, Andrew G Elefanty, J Travis Hinson, Mauro W Costa, Nadia Rosenthal, Milena B Furtado

Faculty Research 2022

Organ fibroblasts are essential components of homeostatic and diseased tissues. They participate in sculpting the extracellular matrix, sensing the microenvironment, and communicating with other resident cells. Recent studies have revealed transcriptomic heterogeneity among fibroblasts within and between organs. To dissect the basis of interorgan heterogeneity, we compare the gene expression of murine fibroblasts from different tissues (tail, skin, lung, liver, heart, kidney, and gonads) and show that they display distinct positional and organ-specific transcriptome signatures that reflect their embryonic origins. We demonstrate that expression of genes typically attributed to the surrounding parenchyma by fibroblasts is established in embryonic development and …

The Apoeε3/Ε4 Genotype Drives Distinct Gene Signatures In The Cortex Of Young Mice, Kate E Foley, Amanda A Hewes, Dylan Garceau, Kevin P Kotredes, Gregory W. Carter, Michael Sasner, Gareth R Howell

Faculty Research 2022

Introduction: Restrictions on existing APOE mouse models have impacted research toward understanding the strongest genetic risk factor contributing to Alzheimer's disease (AD) and dementia, APOE^ε4 , by hindering observation of a key, common genotype in humans - APOE^ε3/ε4 . Human studies are typically underpowered to address APOE^ε4 allele risk as the APOE^ε4/ε4 genotype is rare, which leaves human and mouse research unsupported to evaluate the APOE^ε3/ε4 genotype on molecular and pathological risk for AD and dementia.

Methods: As a part of MODEL-AD, we created and validated new versions of humanized APOE^ε3/ε3 and APOE^{ε4/ε4 …}

Targeting Sox10-Deficient Cells To Reduce The Dormant-Invasive Phenotype State In Melanoma, Claudia Capparelli, Timothy J. Purwin, Mckenna Glasheen, Signe Caksa, Manoela Tiago, Nicole A. Wilski, Danielle Pomante, Sheera Rosenbaum, Mai Q Nguyen, Weijia Cai, Janusz Franco-Barraza, R. Zheng, Md, Gaurav Kumar, I Chervoneva, Ayako Shimada, Vito W Rebecca, Adam E. Snook, Kim Hookim, Xiaowei Xu, Edna Cukierman, Meenhard Herlyn, A E Aplin

Department of Cancer Biology Faculty Papers

Cellular plasticity contributes to intra-tumoral heterogeneity and phenotype switching, which enable adaptation to metastatic microenvironments and resistance to therapies. Mechanisms underlying tumor cell plasticity remain poorly understood. SOX10, a neural crest lineage transcription factor, is heterogeneously expressed in melanomas. Loss of SOX10 reduces proliferation, leads to invasive properties, including the expression of mesenchymal genes and extracellular matrix, and promotes tolerance to BRAF and/or MEK inhibitors. We identify the class of cellular inhibitor of apoptosis protein-1/2 (cIAP1/2) inhibitors as inducing cell death selectively in SOX10-deficient cells. Targeted therapy selects for SOX10 knockout cells underscoring their drug tolerant properties. Combining cIAP1/2 inhibitor …

2022-03-16_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …

Monitoring Sars-Cov-2 In Wastewater During New York City's Second Wave Of Covid-19: Sewershed-Level Trends And Relationships To Publicly Available Clinical Testing Data, Catherine Hoar, Francoise Chauvin, Alexander Clare, Hope Mcgibbon, Esmeraldo Castro, Samantha Patinella, Dimitrios Katehis, John J. Dennehy, Monica Trujillo, Davida S. Smyth, Andrea I. Silverman

Publications and Research

New York City's wastewater monitoring program tracked trends in sewershed-level SARS-CoV-2 loads starting in the fall of 2020, just before the start of the city's second wave of the COVID-19 outbreak. During a five-month study period, from November 8, 2020 to April 11, 2021, viral loads in influent wastewater from each of New York City's 14 wastewater treatment plants were measured and compared to new laboratory-confirmed COVID-19 cases for the populations in each corresponding sewershed, estimated from publicly available clinical testing data. We found significant positive correlations between viral loads in wastewater and new COVID-19 cases. The strength of the …

Evaluation Of The Clarity, Usefulness And Willingness To Adopt A Joint Military Nursing Professional Practice Model By Military Nurse Leaders, Lozay Foots Iii

Graduate Theses, Dissertations, and Capstones

Abstract

The goal of this project was to evaluate the clarity, usefulness and willingness to adopt a Joint Military Nursing Professional Practice Model by military nurse leaders into the military health system. This paper specifically examined leader feedback and perceptions prior to implementation of the Joint Professional Practice Model (JPPM) into designated pilot sites within the Military Health System (MHS) Nursing environment. This project includes Chief Nursing Officer (CNO) discussions reflecting the clarity of definition of model components, usefulness of the model and its components, and willingness to adopt the JPPM. This information will be used to modify the new …

Assessment Of A Cellular Host Response Test To Risk-Stratify Suspected Covid-19 Patients In The Emergency Department Setting, Hollis R. O'Neal, Roya Sheybani, Terrell S. Caffery, Diana Hamer, Jr Mark Laperouse, Mandi W. Musso, Catherine S. O'Neal, Henry T.K. Tse, Ajay M. Shah, Christopher B. Thomas

School of Medicine Faculty Publications

Objective Assess the IntelliSep Index (ISI) for risk stratification of patients presenting to the Emergency Department (ED) with respiratory symptoms suspected of COVID-19 during the pandemic. Methods An observational single-center study of prospective cohort of patients presenting to the ED during the early COVID-19 pandemic with respiratory symptoms and a CBC drawn within 4.5 hours of initial vital signs. A sample of this blood was aliquoted for performance of the ISI, and patients were followed for clinical outcomes. The study required no patient-centered activity beyond standard of care and treating clinicians were unaware of study enrollment and ISI test results. …

Fear Of Falling Avoidance Behavior Assessment And Intervention In Parkinson’S Disease: A Scoping Review, John V. Rider, Jason K. Longhurst, Nirmala Lekhak, Daniel L. Young, Merrill R. Landers

Nursing Faculty Research

Falling and fear of falling (FOF) are significant concerns for people with Parkinson’s disease (PD). FOF can lead to activity avoidance behavior, a risk factor for increased falls and further functional decline. The significant implications of fear of falling avoidance behavior (FFAB) among PD warrant a literature review. The objective of this review was to explore existing literature on FFAB and identify what is known about this phenomenon in people with PD. This scoping review considered studies including adults 18 years and older diagnosed with PD experiencing FFAB. Using Joanna Briggs Institute methodology and the PRISMA extension for scoping reviews, …

“This Isn’T Just Busy, This Is Scary”: Stress, Social Support, And Coping Experiences Of Frontline Nurses During The Covid-19 Pandemic, Erin S. Craw, Tess M. Buckley, Michelle Miller-Day

Communication Faculty Articles and Research

Despite having previous experience and extensive trauma training, the COVID-19 pandemic presented unprecedented challenges for nurses working in hospital settings. During the pandemic, nurses struggle to care for patients and protect themselves from infection, while navigating ongoing organizational changes. Guided by prior literature on social support and coping, this study explores nurses’ experiences of coping with stress while treating COVID-19 patients during the pandemic. In-depth semi-structured interviews were conducted with 14 active staff nurses working in hospitals and one licensed practical nurse (LPN) at a rehabilitation center who treated COVID-19 patients during the pandemic. An inductive thematic analysis was employed …

Predicting Health-Related Social Needs In Medicaid And Medicare Populations Using Machine Learning, Jennifer Holcomb, Luis C Oliveira, Linda Highfield, Kevin O Hwang, Luca Giancardo, Elmer Victor Bernstam

Faculty, Staff and Student Publications

Providers currently rely on universal screening to identify health-related social needs (HRSNs). Predicting HRSNs using EHR and community-level data could be more efficient and less resource intensive. Using machine learning models, we evaluated the predictive performance of HRSN status from EHR and community-level social determinants of health (SDOH) data for Medicare and Medicaid beneficiaries participating in the Accountable Health Communities Model. We hypothesized that Medicaid insurance coverage would predict HRSN status. All models significantly outperformed the baseline Medicaid hypothesis. AUCs ranged from 0.59 to 0.68. The top performance (AUC = 0.68 CI 0.66-0.70) was achieved by the "any HRSNs" outcome, …

Gut-Derived Butyrate Suppresses Ocular Surface Inflammation, Laura Schaefer, Humberto Hernandez, Rosalind A Coats, Zhiyuan Yu, Stephen C Pflugfelder, Robert A Britton, Cintia S De Paiva

Faculty, Staff and Students Publications

Dry eye is a common ocular inflammatory disorder characterized by tear film instability and reduced tear production. There is increasing evidence that homeostasis of the ocular surface is impacted by the intestinal microbiome. We are interested in investigating the potential role of microbially produced small molecules in mediating the interaction between the intestinal microbiota and the ocular surface. One such molecule is butyrate, a short-chain fatty acid (SCFA) produced by certain members of the gut microbiota through fermentation of dietary fiber. Here we show that SCFA transporter SLC5A8 is expressed in vivo in murine conjunctival and corneal epithelium. Pre-treatment of …

Gut-Derived Butyrate Suppresses Ocular Surface Inflammation, Laura Schaefer, Humberto Hernandez, Rosalind A Coats, Zhiyuan Yu, Stephen C Pflugfelder, Robert A Britton, Cintia S De Paiva

Faculty, Staff and Students Publications

Dry eye is a common ocular inflammatory disorder characterized by tear film instability and reduced tear production. There is increasing evidence that homeostasis of the ocular surface is impacted by the intestinal microbiome. We are interested in investigating the potential role of microbially produced small molecules in mediating the interaction between the intestinal microbiota and the ocular surface. One such molecule is butyrate, a short-chain fatty acid (SCFA) produced by certain members of the gut microbiota through fermentation of dietary fiber. Here we show that SCFA transporter SLC5A8 is expressed in vivo in murine conjunctival and corneal epithelium. Pre-treatment of …

Isolated Right Superior Vena Cava Drained To Left Atrium In A Child With Waardenburg Syndrome And Neurofibromatosis Type I, Omer A. Algonaid, Yahya H. Almashham, Abdulrahman S. Almoukirish

Journal of the Saudi Heart Association

Isolated right superior vena cava (SVC) draining to the left atrium (RSVC-LA) is an extremely rare cyanotic congenital heart disease (CHD). Such lesion is easily missed with improper scanning or inattentive interpretation of echocardiography. This can result in potential systemic severe complications. We report a child with RSVC-LA who has two significant non-cardiac co-morbidities, including Waardenburg syndrome and n neurofibromatosis type I (NF1). This patient was referred to cardiology assessment due to unexplained low saturation and was diagnosed as RSVC-LA; however, fortunately not yet showing complications of systemic thromboembolic phenomenon (STEP).

Macronutrients And Water – Do They Matter In The Context Of Cognitive Performance In Athletes?, Ewa Karpecka, Barbara Fraczek

Baltic Journal of Health and Physical Activity

Proper nutrition is a key factor in physical performance, but there are also indications of an impact of dietary components on the brain function. Therefore, the aim of the study was to assess the impact of macronutrients and water on cognitive performance. Assumptions of the Mediterranean diet correlate with better global cognition, episodic memory, lower risk of cognitive impairment and neurodegenerative diseases. In turn, a high-fat and high-sugar diet shows the opposite effect. Omega-3 fatty acids could be used as a preventive tool for cognitive decline, but there is still insufficient evidence if supplementation improves cognitive functions. The proper intake …

The Relationship Between Physical Activity Levels And Health-Related Quality Of Life In Elderly Individuals Aged 65 Years And Above With A Chronic Disease, Nevzat Demirci, Pervin Toptaş Demirci, Oktay Zırhlı

Baltic Journal of Health and Physical Activity

Background: Chronic diseases are the leading cause of death worldwide with increasing prevalence in the population aged 65 years and above. This study aimed to evaluate the relationship between physical activity level and health-related quality of life in elderly individuals. Material and methods: The participants aged 65 years and older (46 males and 35 females) were divided into 3 groups according to their physical activity levels: low physical activity (<150 minutes/week), moderate physical activity (150–300 minutes/week) and high physical activity level (>300 minutes/week). Health-related quality of life (HRQoL) was calculated using EQ-5D scale. Spearman's correlation coefficient was used to determine the relationship between physical activity level and HRQoL scores in elderly …

Model Characteristics Of Sportsmen’ Preparedness In Kettlebell Lifting, Konstiantyn Prontenko, Grygoriy Griban, Tetiana Plachynda, Ivan Mychka, Oksana Khurtenko, Bogdan Semeniv, Oleksandr Gnydiuk, Vadym Muzhychok, Mykola Puzdymir

Baltic Journal of Health and Physical Activity

Background: The model characteristics of preparedness of sportsmen specialized in kettlebell lifting are grounded in the article. The indicators of physical preparedness, functional abilities and the main technical characteristics of kettlebell lifters of different qualification were examined. Material and methods: Three groups were formed: group No. 1 – kettlebell lifters of a low qualification (the 3rd and the 2nd grades, N=34); group No. 2 – kettlebell lifters who have the 1st grade and Candidate Master of Sports, N=27; group No. 3 – sportsmen of a high qualification (Masters of Sports, N=16). The methods of investigation: theoretical analysis and generalization of …

Differences Between All-Around Results In Women’S Artistic Gymnastics And Ways Of Minimizing Them, Almir Atiković, Edina Kamenjašević, Amra Nožinović Mujanović, Edin Užičanin, Muhamed Tabaković, Mijo Ćurić

Baltic Journal of Health and Physical Activity

Background: In the present study, the main goal was to establish whether the disciplines are equal and should the Code of Points (COP) women's artistic gymnastics be revised in terms of point standardization on apparatus. Material and methods: The sample included all-around senior female gymnasts who participated in the qualification (C-I) competitions at World Championships held in 2009-2019. Results: The biggest differences are even two points between the two apparatus vault and balance beam. Vault compared to other apparatus is different for 1.559 points. Presentation of correlations between each apparatus the evidence that nothing has changed significantly in recent years, …

Dependences Between The Footwear Fitting And Feet Structure In Girls Of Third-Grade Primary School, Ewa Puszczalowska-Lizis, Paulina Zarzyczna, Wioletta Mikulakova

Baltic Journal of Health and Physical Activity

Background: The study aimed to study dependences between the footwear fitting and feet structure in girls of third grade of primary school. Material and methods: The research tool was the podoscope CQ-ST. The footwear fitting to the feet of the examined children was tested using the Clevermess device. Results: Statistically significant relationships between the frequency of varus deformity of the Vth toe of the right foot and the width fitting of the outdoor footwear were found (p=0.027). Statistically significant relationships between the length of the indoor footwear and the heel angle (γ) of the left foot have also been noted …

The Impact Of Circuit Resistance Training On Serum Glucose, Insulin Resistance And Health Related Physical Fitness In Elderly Men With Type 2 Diabetes, Hamid Arazi, Roghayeh Gholizadeh, Amin Sohbatzadeh, Ehsan Eghbali

Baltic Journal of Health and Physical Activity

Background: Obesity and decreased physical activity are the most important factors in the development of type 2 diabetes, which in recent decades has led to an increase in the number of people with this disease. The aim of this study was to investigate the impact of circuit resistance training (CRT) on serum glucose, insulin resistance and health related physical fitness in elderly men with type 2 diabetes. Material and methods: Twenty-two patients with type 2 diabetes (60.99 ±2.93 years) volunteered to participate in this study. They were divided randomly into two groups: training (n = 11) and control (n = …

Somatotypes Of Athletes With Physical Disabilities And The Type Of Activity They Undertake, Agata Kamionka, Elzbieta Grzywacz, Mariusz Lipowski

Baltic Journal of Health and Physical Activity

Background: The issue of scientific measurement of somatotypes of athletes with physical disabilities and the type of physical activity undertaken by them is poorly documented in the literature. The aim of the study is to determine what type of body composition is characteristic of athletes with physical disabilities, engaging in various types of physical activity, such as swimming, sitting volleyball and weight lifting. Material and methods: Sixty men, aged 20-30, were qualified for the study. Each study participant had a motor dysfunction and was in intellectual norm. For the research protocol, Sheldon’s typology in Heath and Carter modification was used. …

Concurrent Validity, Inter-, And Intrarater Reliabilities Of Smart Device Based Application For Measuring Vertical Jump Performance, Dong-Sik Oh, Yoon-Hee Choi, Yu-Jin Shim, Sam-Ho Park, Myung-Mo Lee

Baltic Journal of Health and Physical Activity

Background: The aim of this study was to examine the concurrent validity and inter-and intra-rater reliabilities of smart device based application, against force platform-based portable device Wii balance board (WBB) measurements for the flight time and jump height during the vertical jump. Material and methods: Thirty participants (23.8 ±3.41 years) completed three vertical jumps, which were evaluated using WBB and application for smart device. To assess the concurrent validity, jump height and flight times were obtained from each device. Inter-and intra-rater reliabilities were determined by replicating data analysis of smart device based application recordings. Results: Flight time and jump height …

Influence Of Functional Abilities On The Quality Of Refereeing In Handball, Ivan Belcic, Lana Ruzic, Alen Marosevic

Baltic Journal of Health and Physical Activity

Background: Several factors contributed to the evolution of handball, and one of the most important changes for faster, more dynamic and aggressive game is the change of rules which increase physical demands of players and especially referees. The aim of this study is to determine whether functional abilities have an influence on the quality of refereeing. Material and methods: 31 subjects were involved in the research, all of them top-level referees with an average age of 34.66±6.44, height 184.02±5.87 cm and body mass 91.14±10.61 kg. Testing was divided into two parts: the first part was spiroergometric progressive test on a …

Effect Of Core Stability Training On Postural Control, Risk Of Falling, And Function Of The Blind: A Randomized Controlled Trial, Mohammad Karimizadeh Ardakani, Mohammad Hamzeh Shalamzari, Mohammad Hani Mansori

Baltic Journal of Health and Physical Activity

Background: Visual impairments affect all motion aspects of individuals. Movement as the most important tool of physical education is an important factor to improve the health of people with disabilities. The present study aims to investigate the effect of six weeks of core stability training on postural control, risk of falling, and function of blind people. Material and methods: Thirty-two blind males were randomly divided into two groups: the experimental and the control one. In order to evaluate the postural control, the Berg balance scale, the modified stork stand balance test, and the tandem walking test were used. To evaluate …

Effect Of Dynamic And Static Strength Training On Hormonal Activity In Elite Boxers, Eser Ağgön, Özturk Agırbaş, Hamit Hakan Alp, Izzet Uçan, Recep Gürsoy, Anthony C. Hackney

Baltic Journal of Health and Physical Activity

Background: The aim of this study was to determine hormonal responses to acute and chronic exposure to static and dynamic strength training programs using resistance bands in boxers. Material and methods: 19 male national boxers participated in the study. Boxers were instructed to perform strength exercises with resistance bands for 3 days a week for 8 weeks involving either dynamic (n=10) or static (n=9) resistance exercises. Blood samples were taken before exercise, immediately after the initial exercise session, and 8 weeks later following the last exercise session. Cortisol, growth hormone, adrenocorticotropic hormone adrenaline and noradrenaline levels were measured. Statistical analyses …