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Articles 14791 - 14820 of 23761
Full-Text Articles in Medicine and Health Sciences
Assessing The Interplay Effect Based On A Precise Machine-Specific Delivery Sequence And Time For Cyclotron Accelerator Proton Therapy System., Lewei Zhao, Gang Liu, Jiajian Sher, Andrew Lee, Di Yan, Rohan Deraniyagala, Craig Stevens, Xiaoqiang Li, Shikui Tang, Xuanfeng Ding
Assessing The Interplay Effect Based On A Precise Machine-Specific Delivery Sequence And Time For Cyclotron Accelerator Proton Therapy System., Lewei Zhao, Gang Liu, Jiajian Sher, Andrew Lee, Di Yan, Rohan Deraniyagala, Craig Stevens, Xiaoqiang Li, Shikui Tang, Xuanfeng Ding
Conference Presentation Abstracts
Purpose: We proposed an experimental approach to build a precise machine-specific model for standard, volumetric, and layer repainting delivery based on a cyclotron accelerator system. Then, we assessed the interplay effect using a 4D mobile lung target phantom compared to a generic delivery sequence model from West German Proton Therapy Essen (WPE). Methods: The machine delivery log files, from an IBA ProteusPLUSt system, were retrospectively analyzed to quantitatively model energy layer switching time, spot switching time, and spot drill time for standard and volumetric repainting delivery. To quantitatively evaluate the interplay effect, a series of digital thoracic 4DCT image sets …
The Role Of Palmitoleic Acid In Regulating Hepatic Gluconeogenesis Through Sirt3 In Obese Mice, Xin Guo, Xiaofan Jiang, Keyun Chen, Qijian Liang, Shixiu Zhang, Juan Zheng, Xiaomin Ma, Hongmei Jiang, Hao Wu, Qiang Tong
The Role Of Palmitoleic Acid In Regulating Hepatic Gluconeogenesis Through Sirt3 In Obese Mice, Xin Guo, Xiaofan Jiang, Keyun Chen, Qijian Liang, Shixiu Zhang, Juan Zheng, Xiaomin Ma, Hongmei Jiang, Hao Wu, Qiang Tong
Faculty, Staff and Students Publications
Hepatic gluconeogenesis is a crucial process to maintain glucose level during starvation. However, unabated glucose production in diabetic patients is a major contributor to hyperglycemia. Palmitoleic acid is a monounsaturated fatty acid (16:1n7) that is available from dietary sources. Palmitoleic acid exhibits health beneficial effects on diabetes, insulin resistance, inflammation, and metabolic syndrome. However, the mechanism by which palmitoleate reduces blood glucose is still unclear. SIRT3 is a key metabolism-regulating NAD+-dependent protein deacetylase. It is known that fasting elevates the expression of SIRT3 in the liver and it regulates many aspects of liver’s response to nutrient deprivation, such as fatty …
Assessment Of Travel Distance For Hyperthermic Intraperitoneal Chemotherapy In Women With Ovarian Cancer, Laura M Chambers, Meng Yao, Molly Morton, Morgan Gruner, Anna Chichura, Anthony B Costales, Max Horowitz, Peter G Rose, Chad M Michener, Robert Debernardo
Assessment Of Travel Distance For Hyperthermic Intraperitoneal Chemotherapy In Women With Ovarian Cancer, Laura M Chambers, Meng Yao, Molly Morton, Morgan Gruner, Anna Chichura, Anthony B Costales, Max Horowitz, Peter G Rose, Chad M Michener, Robert Debernardo
Faculty, Staff and Students Publications
OBJECTIVE S: To evaluate travel distance in women with advanced or recurrent epithelial ovarian cancer (OC) undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) and the subsequent impact upon outcomes.
METHODS: An IRB-approved single-institution prospective registry was queried for women with OC who underwent HIPEC from 1/1/2009-12/1/2020. Demographic, oncologic, and surgical data were recorded. The patient's home zip code was compared to the institutional zip code to determine travel distance using Google Maps. Patients were divided into three strata for analysis: 1) local: ≤50 miles, 2) regional: 51-99 miles, and 3) distant: ≥100 miles and univariate analysis was performed.
RESULTS: …
Clinical Presentation, Treatment, And Genetic And Histopathological Analysis Of Juvenile Cataracts And Secondary Glaucoma In A Rhesus Macaque (Macaca Mulatta), M Isabel Casanova, Rui Chen, Laura M Garzel, Katherine J Olstad, Soohyun Kim, Ronald Alan Harris, Yumei Li, Muthuswamy Raveendran, Qingnan Liang, Jun Wang, Glenn Yiu, John Timothy Stout, Jeffrey A Roberts, Jeffrey Rogers, Ala Moshiri, Sara M Thomasy
Clinical Presentation, Treatment, And Genetic And Histopathological Analysis Of Juvenile Cataracts And Secondary Glaucoma In A Rhesus Macaque (Macaca Mulatta), M Isabel Casanova, Rui Chen, Laura M Garzel, Katherine J Olstad, Soohyun Kim, Ronald Alan Harris, Yumei Li, Muthuswamy Raveendran, Qingnan Liang, Jun Wang, Glenn Yiu, John Timothy Stout, Jeffrey A Roberts, Jeffrey Rogers, Ala Moshiri, Sara M Thomasy
Faculty, Staff and Students Publications
This report describes the clinical and histological findings, genetic study, and treatment in a 1.3-year-old rhesus macaque with bilateral cataracts and unilateral secondary glaucoma. Intravitreal injection of gentamicin decreased the intraocular pressure from 56 to <2 mm Hg. A putative genetic cause of the cataracts was not identified.
Retinal Organoids Derived From Rhesus Macaque Ipscs Undergo Accelerated Differentiation Compared To Human Stem Cells, Antonio Jacobo Lopez, Sangbae Kim, Xinye Qian, Jeffrey Rogers, J Timothy Stout, Sara M Thomasy, Anna La Torre, Rui Chen, Ala Moshiri
Retinal Organoids Derived From Rhesus Macaque Ipscs Undergo Accelerated Differentiation Compared To Human Stem Cells, Antonio Jacobo Lopez, Sangbae Kim, Xinye Qian, Jeffrey Rogers, J Timothy Stout, Sara M Thomasy, Anna La Torre, Rui Chen, Ala Moshiri
Faculty, Staff and Students Publications
PURPOSE: To compare the timing and efficiency of the development of Macaca mulatta, a nonhuman primate (NHP), induced pluripotent stem cell (rhiPSC) derived retinal organoids to those derived from human embryonic stem cells (hESCs).
RESULTS: Generation of retinal organoids was achieved from both human and several NHP pluripotent stem cell lines. All rhiPSC lines resulted in retinal differentiation with the formation of optic vesicle-like structures similar to what has been observed in hESC retinal organoids. NHP retinal organoids had laminated structure and were composed of mature retinal cell types including cone and rod photoreceptors. Single-cell RNA sequencing was conducted at …
Vestibular Rehabilitation For Peripheral Vestibular Hypofunction: An Updated Clinical Practice Guideline From The Academy Of Neurologic Physical Therapy Of The American Physical Therapy Association, Courtney D Hall, Susan J Herdman, Susan L Whitney, Eric R Anson, Wendy J Carender, Carrie W Hoppes, Stephen P Cass, Jennifer B Christy, Helen S Cohen, Terry D Fife, Joseph M Furman, Neil T Shepard, Richard A Clendaniel, J Donald Dishman, Joel A Goebel, Dara Meldrum, Cynthia Ryan, Richard L Wallace, Nakia J Woodward
Vestibular Rehabilitation For Peripheral Vestibular Hypofunction: An Updated Clinical Practice Guideline From The Academy Of Neurologic Physical Therapy Of The American Physical Therapy Association, Courtney D Hall, Susan J Herdman, Susan L Whitney, Eric R Anson, Wendy J Carender, Carrie W Hoppes, Stephen P Cass, Jennifer B Christy, Helen S Cohen, Terry D Fife, Joseph M Furman, Neil T Shepard, Richard A Clendaniel, J Donald Dishman, Joel A Goebel, Dara Meldrum, Cynthia Ryan, Richard L Wallace, Nakia J Woodward
Faculty, Staff and Students Publications
BACKGROUND: Uncompensated vestibular hypofunction can result in symptoms of dizziness, imbalance, and/or oscillopsia, gaze and gait instability, and impaired navigation and spatial orientation; thus, may negatively impact an individual's quality of life, ability to perform activities of daily living, drive, and work. It is estimated that one-third of adults in the United States have vestibular dysfunction and the incidence increases with age. There is strong evidence supporting vestibular physical therapy for reducing symptoms, improving gaze and postural stability, and improving function in individuals with vestibular hypofunction. The purpose of this revised clinical practice guideline is to improve quality of care …
Methods For Cross-Cultural Communication In Clinic Encounters, Princess U Ogbogu, Lenora Mendoza Noroski, Kimberly Arcoleo, Benjamin D Reese, Andrea J Apter
Methods For Cross-Cultural Communication In Clinic Encounters, Princess U Ogbogu, Lenora Mendoza Noroski, Kimberly Arcoleo, Benjamin D Reese, Andrea J Apter
Faculty, Staff and Students Publications
Successful cross-cultural communication is critical for adequate exchange of ideas with our patients. Our communities have become more diverse, and thus, the necessity has increased. The murder of George Floyd and other atrocities have sparked recognition of the need to address social injustice and racism and as we fight the ongoing coronavirus disease 2019 (COVID-19) pandemic. Allergist-immunologists are uniquely trained to explain the complex immunology of COVID-19 to patients, but they have less experience discussing issues of health equity. Here, we explore critical components of patient-provider communication: communicating with those for whom English is a second language, advising patients with …
Prevalence And Predictors Of Missed Dysplasia On Index Barrett's Esophagus Diagnosing Endoscopy In A Veteran Population, Theresa H Nguyen, Aaron P Thrift, Rollin George, Daniel G Rosen, Hashem B El-Serag, Gyanprakash A Ketwaroo
Prevalence And Predictors Of Missed Dysplasia On Index Barrett's Esophagus Diagnosing Endoscopy In A Veteran Population, Theresa H Nguyen, Aaron P Thrift, Rollin George, Daniel G Rosen, Hashem B El-Serag, Gyanprakash A Ketwaroo
Faculty, Staff and Students Publications
BACKGROUND & AIMS: Limitations of endoscopic sampling may result in missed dysplasia at the diagnosis of Barrett's esophagus (BE). However, the role of close follow-up endoscopy is unclear. The aim was to evaluate the proportion of patients diagnosed with "missed" dysplasia within 18 months of their index nondysplastic BE (NDBE) diagnosis.
METHODS: This was a retrospective analysis of a cohort of BE patients diagnosed during 1990-2019 at the Houston VA. Patients with BE on index esophagogastroduodenoscopy (EGD) were classified as NDBE, indefinite dysplasia, or dysplastic (low- or high-grade dysplasia) based on initial biopsies. We identified NDBE patients who had follow-up …
Single-Cell Transcriptional Profiling Of Murine Conjunctival Immune Cells Reveals Distinct Populations Expressing Homeostatic And Regulatory Genes, Jehan Alam, Ghasem Yazdanpanah, Rinki Ratnapriya, Nicholas Borcherding, Cintia S De Paiva, Dequan Li, Stephen C Pflugfelder
Single-Cell Transcriptional Profiling Of Murine Conjunctival Immune Cells Reveals Distinct Populations Expressing Homeostatic And Regulatory Genes, Jehan Alam, Ghasem Yazdanpanah, Rinki Ratnapriya, Nicholas Borcherding, Cintia S De Paiva, Dequan Li, Stephen C Pflugfelder
Faculty, Staff and Students Publications
Immune cells in the exposed conjunctiva mucosa defend against environmental and microbial stresses. Expression profiling by single-cell RNA sequencing was performed to identify conjunctival immune cell populations expressing homeostatic and regulatory genes. Fourteen distinct clusters were identified, including myeloid cells (neutrophils, monocytes, macrophages), dendritic cells (DC), and lymphoid cells (B, T, γδT, ILC2, and NK) lineages. Novel neutrophil [lipocalin (Lcn2) high and low), and MHCIIlo macrophage (MP) clusters were identified. More than half of the cells map to myeloid and dendritic cell populations with differential expression profiles that include genes with homeostatic and regulatory functions: Serpinb2 (MHCIIlo macrophage), …
Midlife Vascular Factors And Prevalence Of Mild Cognitive Impairment In Late-Life In Mexico, Miguel Arce Renteria, Jennifer J. Manly, Jet M. J. Vonk, Silvia Mejia-Arango, Alejandra Michaels Obregon, Rafael Samper-Ternent, Rebeca Wong, Sandra Barral, Giuseppe Tosto
Midlife Vascular Factors And Prevalence Of Mild Cognitive Impairment In Late-Life In Mexico, Miguel Arce Renteria, Jennifer J. Manly, Jet M. J. Vonk, Silvia Mejia-Arango, Alejandra Michaels Obregon, Rafael Samper-Ternent, Rebeca Wong, Sandra Barral, Giuseppe Tosto
School of Medicine Publications
Objective: To estimate the prevalence of mild cognitive impairment (MCI) and its subtypes and investigate the impact of midlife cardiovascular risk factors on late-life MCI among the aging Mexican population.
Method: Analyses included a sample of non-demented adults over the age of 55 living in both urban and rural areas of Mexico (N = 1807). MCI diagnosis was assigned based on a comprehensive cognitive assessment assessing the domains of memory, executive functioning, language, and visuospatial ability. The normative sample was selected by means of the robust norms approach. Cognitive impairment was defined by a 1.5-SD cut-off per cognitive domain using …
A Study Examining The Usefulness Of A New Measure Of Research Engagement, Deborah J Bowen, Nicole Ackermann, Vetta Saunders Thompson, Andrea Nederveld, Melody Goodman
A Study Examining The Usefulness Of A New Measure Of Research Engagement, Deborah J Bowen, Nicole Ackermann, Vetta Saunders Thompson, Andrea Nederveld, Melody Goodman
2020-Current year OA Pubs
INTRODUCTION: Engagement of relevant stakeholders' ideas, opinions, and concerns is critical to the success of modern research projects. We have developed a tool to measure stakeholder engagement, called the Research Engagement Survey Tool (REST). The purpose of this paper is to present the implementation and uptake of the stakeholder engagement measure REST among research teams, including the assessment of barriers and facilitating factors for use of the new research engagement measure in practice.
METHODS: In this implementation study, project team members participated in baseline and follow-up web-based surveys. Web-based interviews were conducted with a subset of project teams that implemented …
Genetic Variants In Aldh1l1 And Gldc Influence Serine To Glycine Ratio In Hispanic Children, Sergey A. Krupenko, Shelley A. Cole, Ruixue Hou, Karin Haack, Sandra Laston, Nitesh R. Mehta, Anthony G. Comuzzie, Nancy F. Butte, Venkata Saroja Voruganti
Genetic Variants In Aldh1l1 And Gldc Influence Serine To Glycine Ratio In Hispanic Children, Sergey A. Krupenko, Shelley A. Cole, Ruixue Hou, Karin Haack, Sandra Laston, Nitesh R. Mehta, Anthony G. Comuzzie, Nancy F. Butte, Venkata Saroja Voruganti
School of Medicine Publications
Background: Glycine is a proteogenic amino acid that is required for numerous metabolic pathways, including purine, creatine, heme and glutathione biosynthesis. Glycine formation from serine, catalyzed by serine hydroxy methyltransferase, is the major source of this amino acid in humans. Our previous studies in a mouse model have shown a crucial role for the10-formyltetrahydrofolate dehydrogenase (ALDH1L1) enzyme in serine to glycine conversion.
Objectives: To determine the genomic influence on serine-glycine ratio in 803 Hispanic children from 319 families of the Viva La Familia cohort.
Methods: We performed a genome-wide association analysis for plasma serine, glycine, and serine-glycine ratio in SOLAR …
Foxo1 Represses Sprouty 2 And Sprouty 4 Expression To Promote Arterial Specification And Vascular Remodeling In The Mouse Yolk Sac, Nanbing Li-Villarreal, Rebecca Lee Yean Wong, Monica D Garcia, Ryan S Udan, Ross A Poché, Tara L Rasmussen, Alexander M Rhyner, Joshua D Wythe, Mary E Dickinson
Foxo1 Represses Sprouty 2 And Sprouty 4 Expression To Promote Arterial Specification And Vascular Remodeling In The Mouse Yolk Sac, Nanbing Li-Villarreal, Rebecca Lee Yean Wong, Monica D Garcia, Ryan S Udan, Ross A Poché, Tara L Rasmussen, Alexander M Rhyner, Joshua D Wythe, Mary E Dickinson
Faculty, Staff and Students Publications
Establishing a functional circulatory system is required for post-implantation development during murine embryogenesis. Previous studies in loss-of-function mouse models showed that FOXO1, a Forkhead family transcription factor, is required for yolk sac (YS) vascular remodeling and survival beyond embryonic day (E) 11. Here, we demonstrate that at E8.25, loss of Foxo1 in Tie2-cre expressing cells resulted in increased sprouty 2 (Spry2) and Spry4 expression, reduced arterial gene expression and reduced Kdr (also known as Vegfr2 and Flk1) transcripts without affecting overall endothelial cell identity, survival or proliferation. Using a Dll4-BAC-nlacZ reporter line, we found that one of the earliest expressed …
Differences In Covid-19-Related Testing And Healthcare Utilization By Race And Ethnicity In The Veterans Health Administration, Javad Razjouyan, Drew A Helmer, Ang Li, Aanand D Naik, Christopher I Amos, Venkata Bandi, Amir Sharafkhaneh
Differences In Covid-19-Related Testing And Healthcare Utilization By Race And Ethnicity In The Veterans Health Administration, Javad Razjouyan, Drew A Helmer, Ang Li, Aanand D Naik, Christopher I Amos, Venkata Bandi, Amir Sharafkhaneh
Faculty, Staff and Students Publications
IMPORTANCE: Recent reports indicate differences in COVID-19-related care and outcomes between Black and White Americans.
OBJECTIVE: We examine the COVID-19-related healthcare utilization and mortality by race and ethnicity of patients tested for SARS-CoV-2 in the Veterans Health Administration (VHA).
DESIGN: A retrospective cohort study.
SETTING: We used the VHA COVID-19 shared data resources between February 1 and June 30, 2020.
PARTICIPANTS: Veterans tested for SARS-CoV-2 virus by VHA.
EXPOSURE(S): Three racial-ethnicity groups of Black, Hispanic, and White (as reference) veterans.
MAIN OUTCOME(S) AND MEASURE(S): Main outcomes are testing rate, positivity rate, hospitalization rate, ICU admission rate, and in-hospital mortality. Controlling …
A Non-Coding Insertional Mutation Of Grhl2 Causes Gene Over-Expression And Multiple Structural Anomalies Including Cleft Palate, Spina Bifida And Encephalocele, Georgia Pitsava, Marcia L Feldkamp, Nathan Pankratz, John Lane, Denise M Kay, Kristin M Conway, Charlotte Hobbs, Gary M Shaw, Jennita Reefhuis, Mary M Jenkins, Lynn M Almli, Cynthia Moore, Martha Werler, Marilyn L Browne, Chris Cunniff, Andrew F Olshan, Faith Pangilinan, Lawrence C Brody, Robert J Sicko, Richard H Finnell, Michael J Bamshad, Daniel Mcgoldrick, Deborah A Nickerson, James C Mullikin, Paul A Romitti, James L Mills
A Non-Coding Insertional Mutation Of Grhl2 Causes Gene Over-Expression And Multiple Structural Anomalies Including Cleft Palate, Spina Bifida And Encephalocele, Georgia Pitsava, Marcia L Feldkamp, Nathan Pankratz, John Lane, Denise M Kay, Kristin M Conway, Charlotte Hobbs, Gary M Shaw, Jennita Reefhuis, Mary M Jenkins, Lynn M Almli, Cynthia Moore, Martha Werler, Marilyn L Browne, Chris Cunniff, Andrew F Olshan, Faith Pangilinan, Lawrence C Brody, Robert J Sicko, Richard H Finnell, Michael J Bamshad, Daniel Mcgoldrick, Deborah A Nickerson, James C Mullikin, Paul A Romitti, James L Mills
Faculty, Staff and Students Publications
BACKGROUND: Sacral agenesis (SA) consists of partial or complete absence of the caudal end of the spine and often presents with additional birth defects. Several studies have examined gene variants for syndromic forms of SA, but only one has examined exomes of children with non-syndromic SA.
METHODS: Using buccal cell specimens from families of children with non-syndromic SA, exomes of 28 child-parent trios (eight with and 20 without a maternal diagnosis of pregestational diabetes) and two child-father duos (neither with diagnosis of maternal pregestational diabetes) were exome sequenced.
RESULTS: Three children had heterozygous missense variants in ID1 (Inhibitor of DNA …
Targeting Calcium-Mediated Inter-Organellar Crosstalk In Cardiac Diseases, Mohit M Hulsurkar, Satadru K Lahiri, Jason Karch, Meng C Wang, Xander H T Wehrens
Targeting Calcium-Mediated Inter-Organellar Crosstalk In Cardiac Diseases, Mohit M Hulsurkar, Satadru K Lahiri, Jason Karch, Meng C Wang, Xander H T Wehrens
Faculty, Staff and Students Publications
INTRODUCTION: Abnormal calcium signaling between organelles such as the sarcoplasmic reticulum (SR), mitochondria and lysosomes is a key feature of heart diseases. Calcium serves as a secondary messenger mediating inter-organellar crosstalk, essential for maintaining the cardiomyocyte function.
AREAS COVERED: This article examines the available literature related to calcium channels and transporters involved in inter-organellar calcium signaling. The SR calcium-release channels ryanodine receptor type-2 (RyR2) and inositol 1,4,5-trisphosphate receptor (IP
EXPERT OPINION: Enhanced SR calcium release via RyR2 and reduced SR reuptake via SERCA2a, increased VDAC and MCUC-mediated calcium uptake into mitochondria, and enhanced lysosomal calcium-release via lysosomal TPC and TRPML …
Colonic Epithelial Angiotensin-Converting Enzyme 2 (Ace2) Expression In Blacks And Whites: Potential Implications For Pathogenesis Covid-19 Racial Disparities, Mart De La Cruz, David P Nunes, Vaishali Bhardwaj, Deepika Subramanyan, Caroline Zaworski, Priya Roy, Hemant K Roy
Colonic Epithelial Angiotensin-Converting Enzyme 2 (Ace2) Expression In Blacks And Whites: Potential Implications For Pathogenesis Covid-19 Racial Disparities, Mart De La Cruz, David P Nunes, Vaishali Bhardwaj, Deepika Subramanyan, Caroline Zaworski, Priya Roy, Hemant K Roy
Faculty, Staff and Students Publications
BACKGROUND: Covid-19 toll is disproportionate in Blacks although the mechanisms remain incompletely understood. From a biological perspective, several host proteins have received most attention as logical susceptibility targets. Specifically, angiotensin-converting enzyme 2 (ACE2) serves as the epithelial cell receptor and acts in concert with transmembrane protease serine 2 (TMPRSS2). Intriguingly, ACE2 can also suppress the inflammatory response and therefore may impact the severity of Covid-19 infections (from the exuberant immune response a.k.a. "cytokine storm"). We, therefore, assessed expression of ACE2 and TMPRSS2 in Blacks versus Whites.
METHODS: Archived mucosal biopsies from colonoscopic biopsies of visually normal rectal mucosa without concurrent …
Troponin Is Unrelated To Outcomes In Heart Failure Patients Discharged From The Emergency Department, Gregory J Fermann, Douglas Char, Et Al
Troponin Is Unrelated To Outcomes In Heart Failure Patients Discharged From The Emergency Department, Gregory J Fermann, Douglas Char, Et Al
2020-Current year OA Pubs
BACKGROUND: Prior data has demonstrated increased mortality in hospitalized patients with acute heart failure (AHF) and troponin elevation. No data has specifically examined the prognostic significance of troponin elevation in patients with AHF discharged after emergency department (ED) management.
OBJECTIVE: Evaluate the relationship between troponin elevation and outcomes in patients with AHF who are treated and released from the ED.
METHODS: This was a secondary analysis of the Get with the Guidelines to Reduce Disparities in AHF Patients Discharged from the ED (GUIDED-HF) trial, a randomized, controlled trial of ED patients with AHF who were discharged. Patients with elevated conventional …
The Novel Proteomic Signature For Cardiac Allograft Vasculopathy, Dongmei Wei, Sander Trenson, Jan M. Van Keer, Jesus D. Melgarejo, Ella Cutsforth, Lutgarde Thijs, Tianlin He, Agnieszka Latosinska, Agnieszka Ciarka, Thomas Vanassche
The Novel Proteomic Signature For Cardiac Allograft Vasculopathy, Dongmei Wei, Sander Trenson, Jan M. Van Keer, Jesus D. Melgarejo, Ella Cutsforth, Lutgarde Thijs, Tianlin He, Agnieszka Latosinska, Agnieszka Ciarka, Thomas Vanassche
School of Medicine Publications
Aims
Cardiac allograft vasculopathy (CAV) is the major long-term complication after heart transplantation, leading to mortality and re-transplantation. As available non-invasive biomarkers are scarce for CAV screening, we aimed to identify a proteomic signature for CAV.
Methods and results
We measured urinary proteome by capillary electrophoresis coupled with mass spectrometry in 217 heart transplantation recipients (mean age: 55.0 ± 14.4 years; women: 23.5%), including 76 (35.0%) patients with CAV diagnosed by coronary angiography. We randomly and evenly grouped participants into the derivation cohort (n = 108, mean age: 56.4 ± 13.8 years; women: 22.2%; CAV: n = 38) and …
Strategies To Improve Communication In Healthcare: An Integrative Review, Tracy Lynn Macdonald
Strategies To Improve Communication In Healthcare: An Integrative Review, Tracy Lynn Macdonald
Doctoral Dissertations and Projects
The purpose of this integrative review is to research, analyze, critique, and synthesize current literature to determine current practice of communication within healthcare. Communication errors continue to have a negative impact on patient outcomes, so this literature review will consider current strategies to improve communication, and thus improve patient outcomes. Several themes were identified as strategies to improve communication. Although there is abundant research on the topic of communication in healthcare, there is still a need for further adoption and implementation of various communication strategies, as well as a need for further evaluation to determine if these strategies do improve …
Evaluation Of The Effectiveness Of Non-Pharmacological Pain Interventions On Patient Reported Pain Scores And Opioid Use In Hospitalized Adult Patients, Tammy Jane Anderson
Evaluation Of The Effectiveness Of Non-Pharmacological Pain Interventions On Patient Reported Pain Scores And Opioid Use In Hospitalized Adult Patients, Tammy Jane Anderson
Doctoral Dissertations and Projects
The purpose of this integrative review is to research, critique, and synthesize current literature to ascertain the effectiveness of nonpharmacological pain management interventions on hospitalized patient reported pain scores and the use of opioids. Patients report pain while hospitalized for a variety of reasons. In order to become an active participant in their recovery, patients must have their pain adequately controlled. The use of opioids for main management may be required but alternatives exist. These alternatives do not have the same risk factors as opioid pain management. Nonpharmacological interventions included music, virtual reality, massage, guided imagery/hypnosis, and psychological interventions. All …
Predicted Burnout From A Linear Combination Of Personal And Cultural Factors For Departmental Chairs At Academic Health Centers, Loraine Annmarie Antoine
Predicted Burnout From A Linear Combination Of Personal And Cultural Factors For Departmental Chairs At Academic Health Centers, Loraine Annmarie Antoine
Doctoral Dissertations and Projects
Academic departmental chairs at academic health centers have multifaceted roles that entail of faculty obligations, leadership tasks, and the provision of clinical care. Increasing job demands at academic healthcare centers and higher education institutions has led to an increase in burnout, job dissatisfaction, and attrition of faculty and departmental chairs. Departmental chairs at academic health centers must determine strategies to balance their multiple roles held at their institution, as well as roles held in personal aspects of their lives. The purpose of this study was to identify factors that contributed to turnover and job dissatisfaction for academic departmental chairs to …
Anxiety In Healthcare Actors Post Difficult Topic Healthcare Simulation Based Learning Activity, Sarah Elizabeth Pearce
Anxiety In Healthcare Actors Post Difficult Topic Healthcare Simulation Based Learning Activity, Sarah Elizabeth Pearce
Doctoral Dissertations and Projects
Difficult topic healthcare simulation-based learning activities help to prepare healthcare profession students in a manner which is consistent with the experiences they will face in their careers. However, while these types of simulation-based learning activities need to be simulated, little to no research has been conducted regarding the topic of the psychological effect on standardized patients (SP) who participate in these activities within simulation-based learning experiences. The purpose of this study was to provide a quantitative examination, of the anxiety related effects of difficult topic simulation-based learning activities on standardized patients. This study utilized an experimental quantitative post-test only control …
The Relationship Between Leader-Member Exchange And Citizen Willingness To Comply With Governmental Public Health Mandates Concerning Covid-19 In Dougherty County, Georgia: A Mixed Methods Analysis, Travis H. Goodson
Doctoral Dissertations and Projects
As of February 8, 2022, more than 394,381,395 individuals across the globe have contracted COVID-19; and from this number, reportedly more than 5,735,179 have died due to the virus (World Health Organization, 2022). Amid the COVID-19 pandemic, local, state, and federal governments have fielded a host of public health mandates in an attempt to curtail the spread of the virus; however, little is known about the efficacy of such mandates and how willing compliance is obtained through perceived high-quality leader-member exchanges. Compliance is best defined as willing conformity to official requirements; here, compliance is examined through the lens of relational …
Risk Factors Associated With Patient-Reported Fatigue Among Long-Term Oropharyngeal Carcinoma Survivors, Puja Aggarwal, Katherine A Hutcheson, Ryan P Goepfert, Adam S Garden, Naveen Garg, Frank E Mott, Clifton D Fuller, Stephen Y Lai, Gary Brandon Gunn, Mark S Chambers, Ehab Y Hanna, Erich M Sturgis, Sanjay Shete
Risk Factors Associated With Patient-Reported Fatigue Among Long-Term Oropharyngeal Carcinoma Survivors, Puja Aggarwal, Katherine A Hutcheson, Ryan P Goepfert, Adam S Garden, Naveen Garg, Frank E Mott, Clifton D Fuller, Stephen Y Lai, Gary Brandon Gunn, Mark S Chambers, Ehab Y Hanna, Erich M Sturgis, Sanjay Shete
Faculty, Staff and Students Publications
BACKGROUND: The study objective is to identify risk factors associated with fatigue among long-term OPC survivors.
METHODS: This cross-sectional study included disease-free OPC survivors treated curatively between 2000 and 2013 who were surveyed from September 2015 to July 2016. The outcome variable was patient-reported fatigue. Multivariable logistic regression was used to identify factors associated with moderate to severe fatigue.
RESULTS: Among 863 OPC survivors, 17.4% reported moderate to severe fatigue. Self-reported thyroid problems (OR: 2.01; p = 0.003), current cigarette smoking at time of survey (OR: 3.85; p = 0.001), late lower cranial neuropathy (OR: 3.44; p = 0.002), and …
Antimicrobial Susceptibility Testing For Helicobacter Pylori Is Now Widely Available: When, How, Why, David Y Graham, Steven F Moss
Antimicrobial Susceptibility Testing For Helicobacter Pylori Is Now Widely Available: When, How, Why, David Y Graham, Steven F Moss
Faculty, Staff and Students Publications
No abstract provided.
Strengthening Information Literacy Through (Online) Conversation, Kelly Weigand, Antonia Jameson Jordan
Strengthening Information Literacy Through (Online) Conversation, Kelly Weigand, Antonia Jameson Jordan
Georgia International Conference on Information Literacy
There are many controversies surrounding the use of animals for food, and we have observed that veterinary students are interested in deeper consideration of the ethical, moral, and practical implications associated with animal agriculture. Guided by the ACRL Framework for Information Literacy for Higher Education, we developed a discussion-based course focused on the complex issue of consuming animal products to provide practice in seeking and critically evaluating sources.
The course met weekly for eight weeks. Prior to each session, students submitted a brief reflection on the assigned readings and videos, and provided citations for additional relevant materials. Class sessions were …
Creating Positive Teams Using Clifton Strengths, Ronda Christman, Gus Martin, Beth Scott, Jill Buchholz, Deanna Walker, Polina Kadatska
Creating Positive Teams Using Clifton Strengths, Ronda Christman, Gus Martin, Beth Scott, Jill Buchholz, Deanna Walker, Polina Kadatska
Andrews University Teaching and Learning Conference
Our Creator has wired us to be in relations and nurturing teamwork and teambuilding is essential. One way to build cohesion is to have our team complete the Clifton Strengthsfinder survey to identify our top strengths. Once these strengths are identified then we can help people to work more in our strengths.
Our school of nursing and online campus have monthly meetings to make sure we are all on the same page and moving in the same direction. All of the committee members have completed the Clifton Strengthsfinder survey and have shared their top five strengths.
Covid-19 And Telehealth Use Among Occupational Therapy, Physical Therapy, And Speech-Language Pathology Practitioners In The United States, Caesarinne Sprianu, Dragana Krpalek, Julie D. Kugel, Gurinder Bains, Lida Gharibvand
Covid-19 And Telehealth Use Among Occupational Therapy, Physical Therapy, And Speech-Language Pathology Practitioners In The United States, Caesarinne Sprianu, Dragana Krpalek, Julie D. Kugel, Gurinder Bains, Lida Gharibvand
Internet Journal of Allied Health Sciences and Practice
Purpose: To explore occupational, physical, and speech-language pathology therapists’ perceived effectiveness of telehealth and how the COVID-19 pandemic has affected their professional roles. Method: Participants were recruited for the study through a research flyer distrusted via postal mail, emails, social media, and national association websites. An anonymous electronic 19-item survey was developed for this study by the researchers based on a review of the literature and clinical experience. Results. In total, 186 survey responses were obtained, with 152 meeting the inclusion criteria. The average age of participants was 38.6 years with an average work duration of 12.7 years ± 12.5 …