Medicine and Health Sciences Commons^™

The Pathology And Treatment Of Osteoporosis, Shea Munnikhuysen

Senior Honors Theses

Osteoporosis is a disease that causes bone fragility and decreased bone mass. Osteocytes and signaling molecules regulate the function of osteoclasts and osteoblasts. The RANK pathway is a key regulator in osteoclastogenesis. When the osteoclastic function is greater than osteoblastic function, bone integrity decreases. Causes of osteoporosis include hormones, medications, and diet. Treatments for osteoporosis are hormonal, medicinal, and lifestyle changes. More research needs to be done to find more effective medications with fewer negative side effects to improve the overall quality of life for patients. Currently, lab trials are being done on potential new medications to treat osteoporosis.

Determining The Genomic Localization And Binding Partners Of Zinc Finger Protein 410, Mariko Locke

Senior Honors Theses

The results of a folate deficiency study affecting cognition in mice suggested the altered genes may be controlled by a transcription factor known as Zinc Finger Protein 410 (Zfp410). Due to a lack of literature on Zfp410’s interacting proteins and DNA-binding location, our study aims to further elucidate the role Zfp410 plays in affecting cognition. A custom antibody was used to determine the Zfp410 isoforms present in mouse and rat brains. Moreover, the antibody was used to determine the binding partners of Zfp410 in the brain and locate specific genomic regions/sequences with which it associates in vivo. These results may …

Effectivenessofnursingguidelinesonnursesperformanceregardinghighalertmedications, Sara Sayed Abdalla

Nursing

No abstract provided.

The Effects Of Dietary Interventions On Adverse Outcomes In Obese, Preeclamptic-Like Bph/5 Female Mice, Morgan Alston

Honors Capstones

No abstract provided.

Analytics Monthly, Lehigh Valley Health Network

LVHN documents

No abstract provided.

Whole Blood Transcriptome Analysis Of Insulin Sensitive And Insulin Dysregulated Mares, Sarah Lackey

Honors Capstones

No abstract provided.

Inspire : Vol 5, Issue 4, Department Of Medicine

INSPIRE – Department of Medicine Archives

Content

• Medicine at National and International Forums
• 13th Biennial conference of Pakistan Society of Nephrology
• McMaster Faculty visits AKUH Nephrology
• In-depth: featuring Associate Professor & Section Head Infectious Diseases – Dr Faisal Mahmood
• Featured Faculty – Dr Faheem Shaikh – Senior Instructor – Internal Medicine section
• Publications

Improving Heart Failure Patient Referrals To The Center For Advanced Heart Failure & Pulmonary Vascular Disease At Hartford Hospital: A Quality Improvement Project, Dawn M. Surprenant

DNP Projects

Significance and Background: According to the Health Resources & Services Administration (2021), health literacy is the degree to which individuals have the capacity to process and understand basic health information to make appropriate health decisions. Low health literacy is prevalent in populations such as older adults, minorities, and in individuals with lower socioeconomic status and living in medical underserved areas. Recommendations are to access health literacy in cardiac patients, especially in the acute care setting to improve health outcomes upon discharge.

Purpose: To determine whether a health literacy assessment in hospitalized congested heart failure patients, before discharge, will affect referral …

Non-Opioid Pharmacologic Agents In The Treatment Of Non-Cancer Chronic Pain In The Outpatient Setting, Diane Eannotti

DNP Projects

Opioid prescription related overdose deaths have increased substantially with evidence demonstrating only modest short-term benefits in chronic pain and thus represents the need to identify alternative treatments to opioids. A needs assessment performed for a federally qualified community health center revealed patients presently taking non-opioid pharmacologic agents in the treatment of chronic non-cancer pain (CNCP) needed additional education in managing multiple non-opioid medications. A targeted approach at improving patient experience and population health supporting the quadruple aim was undertaken with this project.

Purpose: The purpose of this quality improvement project consisted of performing medication management visits for 28 referred patients …

A Community Engagement Approach For An Integrated Early Childhood Development Intervention: A Case Study Of An Urban Informal Settlement With Kenyans And Embedded Refugees, Margaret Kabue, Amina Abubakar, Derrick Ssewanyana, Vibian Angweny, Joyce Marangu, Eunice Njoroge, Eunice Ombech, Mercy Mokaya, Emmanuel Obulemire, Kofi Marfo

Institute for Human Development, East Africa

Background: Community engagement is crucial for the design and implementation of community-based early childhood development (ECD) programmes. This paper aims to share key components and learnings of a community engagement process for an integrated ECD intervention. The lessons shared are drawn from a case study of urban informal settlement with embedded refugees in Nairobi, Kenya.

Methods: We conducted three stakeholder meetings with representatives from the Ministry of Health at County and Sub-County, actors in the ECD sector, and United Nations agency in refugee management, a transect walk across fve villages (Ngando, Muslim, Congo, Riruta and Kivumbini); and, six …

Artificial Intelligence And Machine Learning For Early Detection And Diagnosis Of Colorectal Cancer In Sub-Saharan Africa, Akbar K. Waljee, Eileen M. Weinheimer-Haus, Amina Abubakar, Anthony Ngugi, Geoffrey H. Siwo, Gifty Kwakye, Amit G. Singal, Arvind Rao, Christopher Opio, Mansoor Saleh

Institute for Human Development, East Africa

No abstract provided.

Neuroprotective Effect Of Liraglutide In An Experimental Mouse Model Of Multiple Sclerosis: Role Of Ampk/Sirt1 Signaling And Nlrp3 Inflammasome, Reham A. Ammar, Ahmed F. Mohamed, Mohamed M. Kamal, Marwa M. Safar, Noha F. Abdelkader

Pharmacy

The heterogeneous nature of multiple sclerosis (MS) and the unavailability of treatments addressing its intricate network and reversing the disease state is yet an area that needs to be elucidated. Liraglutide, a glucagon-like peptide-1 analogue, recently exhibited intriguing potential neuroprotective effects. The currents study investigated its potential effect against mouse model of MS and the possible underlying mechanisms. Demyelination was induced in C57Bl/6 mice by cuprizone (400 mg/kg/day p.o.) for 5 weeks. Animals received either liraglutide (25 nmol/kg/day i.p.) or dorsomorphin, an AMPK inhibitor, (2.5 mg/ Kg i.p.) 30 min before the liraglutide dose, for 4 weeks (starting from the …

Epidemiological Profile And Clinico-Pathological Features Of Pediatric Gynecological Cancers At Moi Teaching & Referral Hospital, Kenya, Anisa W. Mburu, Peter M. Itsura, Elkanah Omenge, Philiph K. Tonui, Elly B. Odongo, Afrin F. Shaffi, Hellen N. Muliro, Thomas N. Achia, Allan L. Covens, Barry P. Rosen

Obstetrics and Gynaecology, East Africa

Background: The main pediatric (0–18 years) gynecologic cancers include stromal carcinomas (juvenile granulosa cell tumors and Sertoli-Leydig cell tumors), genital rhabdomyosarcomas and ovarian germ cell. Outcomes depend on time of diagnosis, stage, tumor type and treatment which can have long-term effects on the reproductive career of these patients. This study seeks to analyze the trends in clinical-pathologic presentation, treatment and outcomes in the cases seen at our facility. This is the first paper identifying these cancers published from sub-Saharan Africa.

Method: Retrospective review of clinico-pathologic profiles and treatment outcomes of pediatric gynecologic oncology patients managed at MTRH between 2010 and …

Exploring Discourse Markers As A Treatment Outcome Measure For Aphasia, Anna K. Cedoz

Masters Theses

Discourse Markers (DMs) are communicative tools or resources that people use to organize conversations. The use of DMs among individuals with aphasia has been documented to support their communicative competence (Simmons-Mackie & Damico, 1996). Further research on the use of DMs by individuals with aphasia has been limited. The current study features a secondary analysis using existing data from Devanga (2020), which studied the effects of Collaborative Referencing Intervention (CRI; Hengst et al., 2010) on three participants with chronic aphasia. This study analyzed 18 conversation probes from one participant across baseline, treatment, and maintenance phases with clinician and spouse partners. …

Baroreflex Sensitivity In Facioscapulohumeral Muscular Dystrophy, Miguel Anselmo, Shandon Coffman, Mia Larson, Kathryn Vera, Emma Lee, Mary Mcconville, Michael Kyba, Manda L Keller-Ross

Department of Medicine Faculty Papers

Facioscapulohumeral muscular dystrophy (FSHD), a common form of muscular dystrophy, is caused by a genetic mutation that alters DUX4 gene expression. This mutation contributes to significant skeletal muscle loss. Although it is suggested that cardiac muscle may be spared, people with FSHD have demonstrated autonomic dysregulation. It is unknown if baroreflex function, an important regulator of blood pressure (BP), is impaired in people with FSHD. We examined if baroreflex sensitivity (BRS) is blunted in patients with FSHD. Thirty minutes of resting BP, heart rate, and cardiovagal BRS were measured in 13 patients with FSHD (age: 50 ± 13 years, avg …

Developing An Evidence-Based Preceptor Program To Improve The Orientation Process, Emily Nobles

Doctor of Nursing Practice (DNP) Translational and Clinical Research Projects

Background: Creating a positive experience for the new nurse during the orientation period is vital in ensuring safe practice, employee satisfaction, and improved self-efficacy and retention of the employee long-term. Problem: At a 245-bed acute care hospital in the southeastern United States, nursing retention and preceptor practices have surfaced as an opportunity for improvement. Methods: A quality improvement project involving the implementation of an evidence-based preceptor program with formal preceptor education, preceptor application, and a standardized feedback tool was evaluated to determine the effect on preceptor/preceptee self-efficacy, intent to stay, and preceptor engagement. Results: 10 preceptor-preceptee pairs with previous nursing …

Cis-Acting Super-Enhancer Lncrnas As Biomarkers To Early-Stage Breast Cancer, Ali Salman Ropri

Legacy Theses & Dissertations (2009 - 2024)

Abstract

Occupational Therapy's Role In Serious Mental Illness, Sam Sutton, Anabelle Scalora, Tina Deangelis

Doctorate of Occupational Therapy Program Capstone Presentations

The intent of this electronic manual is to provide a client-centered and evidence-based resource to inform students, clinicians, and educators of occupational therapy’s unique role in working with adults with serious mental illness (SMI) and those experiencing psychosis. This manual, while not exhaustive, is designed to serve as a user-friendly resource for providing valid, equitable care to those with serious mental illness.

Objectives:

1. Provide an electronic resource that outlines the occupational therapy process when working with individuals with serious mental illness and supports inclusion and reimbursement for occupational therapy practitioners in this setting.
2. Define the multiple roles occupational therapy practitioners …

Genetic Testing For Non-Major Biology Students, Taylor Banton

Honors Projects

The goal of this Honors Project is to teach non-major biology students (BIOL-100) the concept of genetic testing and the importance of interpreting genetic results. I created a lab manual, a PowerPoint presentation, and quiz assessments to help students easily understand the material while also performing lab techniques that are crucial to scientific research. This is a two-week lab where students will test their own DNA and interpret the results using PCR and gel electrophoresis. In the lab at school, students cannot obtain real genetic results because the lab focuses on a portion of the genome that is not used …

Promoting Sustainable Responses To The Us Opioid Epidemic With Community-Academic Partnerships: Qualitative Outcomes From A Statewide Program, David L. Driscoll, Alison Evans Cuellar, Vinod Agarwal, Debra Jones, Kathy Hosig, Mary Beth Dunkenberger

Economics Faculty Publications

Background: Drug overdose deaths in the United States have continued to increase at an alarming rate. The United States is facing two devastating public health crises– the opioid epidemic and the COVID-19 pandemic. Within this context, one of the most ambitious implementation studies in addiction research is moving forward. Launched in May 2019, the HEALing Communities Study (HCS) was developed by the National Institutes of Health (NIH) and the Substance Abuse and Mental Health Services Administration (SAMHSA) as part of the Helping to End Addiction Long-termSM Initiative (National Institutes of Health, 2020). The goal for this research was to reduce …

Predictors Of First-Time National Board Passage For Respiratory Therapists, Jennifer Kay Riggs

Dissertations

Respiratory therapists fulfill a vital role that saves and improves lives. To achieve recognition for their knowledge, unique skills, and dedication to clinical excellence, they must pass a series of national board exams. Achieving credentials from the National Board of Respiratory Care (NBRC) is a challenge, a true testament to the skills and strengths required for excellence in the profession. The problem prompting this study is the number of respiratory graduates who are not passing the Therapist Multiple Choice (TMC) exam on their first attempt. The goal of respiratory programs is to prepare graduates for success on the TMC exam …

A Scoping Review Of Injuries In Amateur And Professional Men's Ice Hockey., Patrick F Szukics, Peters T Otlans, Alfonso Arevalo, Matthew Meade, Peter Deluca, John P Salvo

Orthopedic Surgery Resident Research

Background: Orthopaedic injuries are common in ice hockey at all levels and can result in physical and psychological adverse effects on these athletes.

Purpose: Primarily, to summarize published data on orthopaedic hockey injuries at the junior through professional level. Secondarily, to characterize the literature based on anatomic site injured, return-to-play rates, cause/mechanism of injury, time lost, and treatments used.

Study Design: Scoping review; Level of evidence, 4.

Methods: PubMed, EMBASE, Cochrane library, and SCOPUS were searched using the terms "hockey" and "injuries" using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, and 4163 studies involving orthopaedic injuries were …

A Scoping Review Of Injuries In Amateur And Professional Men's Ice Hockey, Patrick F Szukics, Peters T Otlans, Alfonso Arevalo, Matthew Meade, Peter Deluca, John P Salvo

Orthopedic Surgery Resident Research

Background: Orthopaedic injuries are common in ice hockey at all levels and can result in physical and psychological adverse effects on these athletes.

Purpose: Primarily, to summarize published data on orthopaedic hockey injuries at the junior through professional level. Secondarily, to characterize the literature based on anatomic site injured, return-to-play rates, cause/mechanism of injury, time lost, and treatments used.

Study Design: Scoping review; Level of evidence, 4.

Methods: PubMed, EMBASE, Cochrane library, and SCOPUS were searched using the terms "hockey" and "injuries" using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, and 4163 studies involving orthopaedic injuries were …

Cultural Healing Practices: Incorporating Cultural Healers Into Minnesota's Mental Health Care System, Raymond Shoup, Allyson Endersbe, Nayeli Hernandez Moctezuma, Patty Balderas-Johnson

Master of Social Work Student Policy Advocacy Briefs

Minnesota’s approach to health and mental health is based on western cultural traditions of illness, help seeking behaviors, healing and wellness. This approach does not work for many of the cultural communities in Minnesota, especially those with a deep history of generational trauma, oppression, and discrimination. We need to make mental health a priority for Minnesotans by expanding the availability of holistic approaches rooted in the cultural traditions of Minnesota’s diverse cultural communities. We must address the impact of generational trauma and work to lessen the harm by incorporating cultural healing practices into our mental health care system, including the …

Integration Of Arts And Humanities In Medicine To Develop Well-Rounded Physicians: The Roles Of Health Sciences Librarians, Misa Mi, Lin Wu, Yingting Zhang, Wendy Wu

Library Scholarly Publications

Over the past ten years, there has been a growing interest in integrating arts and humanities in medicine to increase learners’ empathy and resilience, improve personal well-being, communication, and observational skills, enhance self- reflection, and promote professionalism. These desired skills and qualities are becoming increasingly important for the physicians of tomorrow. Parallel to curricular interventions of integrating arts and humanities to medical education, there has been an increasing research interest in investigating the impact of such interventions on medical students with respect to improving and sustaining students’ empathy as they progress in their medical education and develop their professional identity. …

2022 Nursing Annual Report, System Of Texas Children's Health

2022

No abstract provided.

Genes Involved In Cell Division In Acinetobacter Baumannii Are Coregulated By Umudab And Ddrr, Belinda Candra, Xiaohong Li, Eric Rouchka, Deborah Cook, Janelle Hare

2022 Celebration of Student Scholarship - Poster Presentations

In the presence of DNA damage, the multi-drug resistant bacteria Acinetobacter baumannii employs the proteins UmuDAb and DdrR to repress the expression of error-prone polymerases.

Comparative Kinematic Gait Analysis In Adults With Multiple Disabilities, Lauren Rumbalski

Undergraduate Honors Thesis Projects

The purpose of this research is to identify abnormal gait parameters or patterns amongst young adults with multiple disabilities enrolled in a work transition program sponsored by a public-school system. Gait disorders are commonly seen in individuals with neurologic disorders, with significant research in children with autism. Gait disorders have been linked with fall and injury risk, with significant research in elderly populations. Gait analysis technology can be used to identify gait characteristics in populations that are abnormal or contribute to gait disorders. In an observational design, students from the transitional program promoted by Westerville City Schools, housed on Otterbein …

Does Age-Related Macular Degeneration (Amd) Treatment Influence Patient Falls And Mobility? A Systematic Review., Hannah Garrigan, Jacquelyn N. Hamati, Parth Lalakia, Rosemary Frasso, Brooke Salzman, Leslie Hyman

Student Papers, Posters & Projects

PURPOSE: Age-related macular degeneration (AMD), a leading cause of irreversible blindness, increases fall risk through impaired central vision. Falls place an enormous economic burden on healthcare systems. We hypothesized that AMD treatments may reduce patients' falls risk. This systematic review (ID #: 172623) synthesized the current understanding of wet and dry AMD treatments' impact on patient falls and mobility, connecting these two public health issues.

METHODS: On April 17, 2020, PubMed, Scopus, CINAHL, and the Cochrane Central Register of Controlled Trials were queried. Clinical trials and observational studies were included, while non-English and non-primary studies were excluded. Two authors screened, …

Keynote Address 1: Physical Therapist Experience On Long Covid. Maribeth Ann P. Gelisanga. Philippine Physical Therapy Association National Convention- Impetus 2021 December 4, 2021

Philippine Journal of Physical Therapy

Keynote Address 1: Physical Therapist Experience on Long COVID. Maribeth Ann P. Gelisanga. Philippine Physical Therapy Association National Convention- IMPETUS 2021 December 4, 2021.