Medicine and Health Sciences Commons^™

The Development Of Inhibitors For Sars-Cov-2 Orf8, My Thanh Thao Nguyen

CSB and SJU Distinguished Thesis

An unexpected outbreak of SARS-CoV-2 caused a worldwide pandemic in 2020. Many repurposed drugs were tested, but there are currently only three FDA approved antivirals (Merck’s antiviral Molnupiravir, Pfizer’s antiviral Paxlovid, and Remdisivir).1 Most of the antiviral drugs tested SARS-CoV-2 main protease and RNA-dependent RNA polymerase. However, it is important to explore different drug targets of SARS-CoV-2 to prepare for the virus mutations of the future. This research looks at an alternative approach in which SARSCoV- 2 Open Reading Frame 8 (ORF8), which has been shown to be a rapidly evolving hypervariable gene, was chosen to be the protein of …

Sars-Cov-2 Main Protease Inhibitors Repurposed For Hiv-1 Protease Binding, Jacob Minkkinen

CSB and SJU Distinguished Thesis

Severe acute respiratory syndrome (SARS-CoV-2) led to the COVID-19 global pandemic, with over 460 million cases of infection and over 6 million deaths since the start of the pandemic. SARS-CoV-2 is a retrovirus that utilizes a main protease (Mpro). Mpro is a catalytic cys/his protease. Several treatments were proposed to stop the pandemic including repurposing drugs to inhibit the Mpro. Another retrovirus that uses a protease is human immunodeficiency virus (HIV-1) which has been a global epidemic for 40 years and is a devastating disease that attacks the immune system. HIV-1 has infected 79.5 million people and has killed an …

Standing Weight Perception Across Unweighted Conditions In A Lower Body Positive Pressure Treadmill, Madison Rees, Matthew Ballesteros, Danielle Toth, Erik Lind, Bryanne N. Bellovary, James F. Hokanson

Transformations: Presentation Slides

Lower body positive pressure treadmills (LBPP-TM) provide assistive body weight support to the user by forcing air into an inflatable chamber in which the user is secured. The result of this positive pressure can be experienced as a lift to the user. The degree of chamber air pressure (CAP) determines the amount of supportive lift provided with greater and lesser CAP producing more and less lift, respectively. Exercise studies consistently report lower effort perceptions with greater CAP which suggest a reduced physiological and mechanical strain on the body. What is less well known is the effect on resting perceptions of …

Adolescent Mothers And Kangaroo Mother Care: A Scoping Review, Genna K. Rivers, Robin B. Dail Phd, Rn, Faan, Robin Dawson Phd, Rn, Cpnp-Pc

Senior Theses

Kangaroo mother care (KMC), the practice in which mothers hold their infants skin-to-skin against their bare chest, can increase bonding and attachment between mothers and their infants. However, there is not much research on the benefits of KMC within the adolescent or teen mother population (13-19 years old). The purpose of this scoping review was to identify how common KMC is within the teen mother population, determine how KMC varies based on social determinants of health and race/ethnicity within the adolescent mother population, and how KMC impacts adolescent mothers’ maternal attachment and bonding with their infants. PubMed and CINAHL databases …

“Pandemias Políticas: The Effects Of Political And Social Instability On Infectious Disease Epidemiology In Latin America"”, Sarah H. Noonan

Senior Theses

This paper seeks to analyze the relationship between political and social unrest and conflict and infectious disease epidemiology in Latin America. An analysis of published literature regarding epidemiological, biomedical, political, and historical content was conducted to highlight potential connections between infectious disease epidemics and sociopolitical conflict in the region. Specific analyses of Smallpox, Venezuelan Equine Encephalitis, Chagas disease, Cholera, Dengue, and COVID-19 were conducted, in an effort to uncover potential causations and context of epidemics of these conditions. Results of this analysis depict a necessity for further research into public health and disease control mechanisms during times of conflict and …

The Role Of American Domestic Medicine In The Nineteenth Century: Implications For Modern Populations With Low Access To Health Care, Savannah Allen

Senior Theses

Domestic medicine can be defined as medical treatment provided within the home or community that is administered by a member of that home or community who is not a physician, surgeon, or nurse. During the late nineteenth and early twentieth century, domestic medicine flourished as housewives began to take on the role of medical practitioner. This was an attempt to alleviate the stress of low healthcare access that plagued lower-income and rural communities. Among lower- and middle-class communities in present day, we continue to see disparities in access to quality health care. I will argue that telemedicine has transformed during …

El Impacto De La Pandemia En La Formación De Los Hábitos De Alimentación En Niñes Pequeñes En La Villa 21-24 En Barracas, Buenos Aires / The Impact Of The Pandemic In The Creation Of Nutritional Habits In Young Children In Villa 21-24 In Barracas, Buenos Aires, Hannah Seewald

Independent Study Project (ISP) Collection

Durante la Pandemia COVID-19 en Argentina, la inflación aumentó, y el desempleo aumentó especialmente entre los trabajadores informales, lo que dejó a muchos de ellos dependientes de los comedores comunitarios y de la ayuda nutricional para alimentar a sus familias. La violencia doméstica y la pobreza aumentaron aún más. Problemas estructurales como la falta de agua potable y los cortes de luz, situaciones que suelen enfrentar los habitantes de la Villa 21-24, Barracas, Buenos Aires, continuaron. Las escuelas se cerraron y la instrucción presencial se suspendió, en ese contexto los grupos comunitarios trabajaron para alcanzar los suministros adecuados de alimentos. …

Shinetagantsi: Un Caso De La Alimentación Materna E Infantil Y Medicina Intercultural Durante Lactancia En La Comunidad Nativa De Palotoa Teparo, Layne Scopano

Independent Study Project (ISP) Collection

Con un enfoque antropológico, esta investigación analiza las percepciones del cuidado desde los sistemas médicos occidentales y la medicina tradicional de las madres de la comunidad nativa de Palotoa Teparo en la Amazonía peruana en lo que respecta a la nutrición durante la lactancia. Los resultados de este estudio, obtenidos a través de entrevistas semiestructuradas y observación directa e indirecta, permiten describir el estado nutricional de las madres de Palotoa Teparo durante la lactancia y su relación con la nutrición infantil, señalar las prácticas de salud, tanto occidental como tradicional, relevantes para el estado nutricional de las madres y los …

Commentary On “Infants With Torticollis Who Changed Head Presentation During A Physical Therapy Episode”, Kathryn Knudsen, Ryan Jacobson, Kirsten Pepperling

Faculty Publications - College of Physical Therapy

This article highlights the importance of differential diagnosis in infants with congenital muscular torticollis (CMT), particularly those with atypical presentation or change of side for range-of-motion (ROM) restriction. Per the clinical practice guideline (CPG), patients who change sidedness with CMT should be reevaluated by the physical therapist and referred back to the primary care provider for consideration of other diagnoses.1 This recommendation is important to parents who are seeking accurate information on cause and severity and who want to know that the home exercises being prescribed for their infant are effective

Analysis Of Clinical Outcomes And Cost-Effectiveness Of Neuromuscular Blocking Drug Reversal In Patients With Obstructive Sleep Apnea, Samantha Kinglsey, Aaron "Mitch" Corn

Doctor of Nursing Practice Scholarly Projects

Non-depolarizing neuromuscular blockers are used during many surgical procedures to induce muscle relaxation for tracheal intubation and improve surgical conditions for surgeons. The use of these medications requires an agent to be given to fully reverse the effects of the neuromuscular blocking drug. Historically, neostigmine has widely been used as the primary reversal agent. However, sugammadex, a recently FDA approved drug, is also available for the reversal of common neuromuscular blocking drugs, rocuronium and vecuronium. In the literature, sugammadex is widely regarded as a clinically superior reversal agent. But its use is commonly limited to emergent situations due to the …

Computer-Aided Diagnosis For Melanoma Using Ontology And Deep Learning Approaches, Xinyuan Zhang

Dissertations and Theses (Open Access)

The emergence of deep-learning algorithms provides great potential to enhance the prediction performance of computer-aided supporting diagnosis systems. Recent research efforts indicated that well-trained algorithms could achieve the accuracy level of experienced senior clinicians in the Dermatology field. However, the lack of interpretability and transparency hinders the algorithms’ utility in real-life. Physicians and patients require a certain level of interpretability for them to accept and trust the results. Another limitation of AI algorithms is the lack of consideration of other information related to the disease diagnosis, for example some typical dermoscopic features and diagnostic guidelines. Clinical guidelines for skin disease …

A Case Series Of Three Patients With Rare Pantalar Dislocation, Marissa Mogavero, Andrew Robitaille, Lawrence M. Fallat

Articles

Total talar dislocations are rare, significant surgical challenges for foot and ankle surgeons. These dislocations can be very difficult to manually close-reduce, requiring immediate surgical intervention secondary to arterial impingement, pain and risk of skin necrosis attributable to skin tenting. In this case series, we report on three patients who presented to the emergency room following a traumatic ankle injury. Ankle radiographs and computed tomography (CT) scans were obtained, revealing pantalar dislocations. Closed reduction utilizing Charnley’s principles was attempted in the emergency room through manual accentuation of the deformity, traction and reduction. Closed reduction was unsuccessful in all three patients …

Neurogenic Stuttering: Exploring Potential Emotional And Life Impact, Natalie Devries

Masters Theses

The purpose of the current study was to explore the potential emotional and life impact of living with neurogenic stuttering and how and when an impact develops, if present. The current diagnostic criteria for neurogenic stuttering includes no emotional impact (Canter, 1971). The literature is divided in supporting this criterion (Lebrun et al., 1990; Leder et al., 1996; Perino et al., 2000; Theys et al., 2008; Tani &Sakai, 2011; Ellis & Sheehy, 2013; Vanhoutte et al., 2014). The current study relied on qualitative interviewing which was analyzed using Reflexive Thematic Analysis to explore potential for emotional and life impact (Braun …

Pentavalent Vaccination In Kenya: Coverage And Geographical Accessibility To Health Facilities Using Data From A Community Demographic And Health Surveillance System In Kilifi County, Morris Ogero, James Orwa, Rachel Odhiambo, Felix Agoi, Adelaide Lusambili, Jerim Obure, Marleen Temmerman, Stanley Luchters, Anthony Ngugi

Population Health, East Africa

Background: There is substantial evidence that immunization is one of the most significant and cost-effective pillars of preventive and promotive health interventions. Effective childhood immunization coverage is thus essential in stemming persistent childhood illnesses. The third dose of pentavalent vaccine for children is an important indicator for assessing performance of the immunisation programme because it mirrors the completeness of a child’s immu- nisation schedule. Spatial access to an immunizing health facility, especially in sub-Sahara African (SSA) countries, is a significant determinant of Pentavalent 3 vaccination coverage, as the vaccine is mainly administered during routine immunisation schedules at health facilities. …

Diode Laser Assisted Abscission And Low Level Laser Therapy For The Treatment Of Mucocele –Literature Update And Case Report, Divya Khanna Bds, Mds, Nikita Dhingra Bds, Md, Rohit Yadav Bds, Mds

The New York State Dental Journal

Mucoceles are the quotidian, benign minor salivary gland lesions of the oral mucosa. They result from the accumulation of mucous secretion due to trauma or alteration of minor salivary glands. Clinically they are characterized by bluish, dome shaped, soft and fluctuant physiognomy with most frequent occurrence reported on the lower lip. Based on the histological features they are of two varieties mucous extravasation and retention cysts. Various treatment modalities including surgery, laser ablation, electrosurgery, marsupialization, cryosurgery, intra-lesional injections and corticosteroids have been reported in literature. In the present case, a mucosal preservation technique was used in conjunction with an 810nm …

Subjective Observation Of Loss Of Subcutaneous Fat And Muscle Tissue – Is That The Answer To Pediatric Hospital Malnutrition Screening?, Grace C. Barcus

Master's Theses

Background: Hospital malnutrition is a prevalent issue with critically ill pediatric patients being at increased risk for nutritional loss. Nutritional risk screening has been associated with increased documentation of nutrition diagnosis and positive clinical outcomes, however, is not mandatory in developing countries. A nutrition screening tool that uses subjective examination of loss of subcutaneous fat and muscle tissue may be an efficient way to identify nutritional risk in hospitalized critical care pediatric patients.

Objective: To determine whether loss of subcutaneous fat and muscle tissue in specific body locations was associated with moderate or severe malnutrition determined by SGA in pediatric …

Data From: A Protracted Developmental Trajectory For English-Learning Children’S Detection Of Consonant Mispronunciations In Newly Learned Words, Carolyn Quam, Daniel Swingley

Speech and Hearing Sciences Faculty Datasets

Children are adept at learning their language’s speech-sound categories, but just how these categories function in their developing lexicon has not been mapped out in detail. Here, we addressed whether, in a language-guided looking procedure, two-year-olds would respond to a mispronunciation of the voicing of the initial consonant of a newly learned word. First, to provide a baseline of mature native-speaker performance, adults were taught a new word under training conditions of low prosodic variability. In a second experiment, 24- and 30-month-olds were taught a new word under training conditions of high or low prosodic variability. Children and adults showed …

Medical Norm Of Psychiatric Misdiagnoses In Rare Disease Patients, Rachel Han

Publications and Research

Spring 2022 ENG 120 Student Final Research Paper on the medical norm of psychiatric misdiagnosis throughout the diagnostic journeys of rare disease patients. The idea of a norm was taken from Chimamanda Ngozi Adichie's Tedx Talk "The Danger of a Single Story". Paper discusses prevalence, harmful effects, and origin of this medical norm. Includes discussion of statistical data quoted relating to prevalence of rare diseases as well as anecdotal evidence of the severe ramifications of this norm. Discussion of how medically unexplained symptoms such as mysterious chronic pain often lead to the phenomenon of the psychogenic inference. Origins of this …

Restoring Wholeness To Psychiatry: Models Of Understanding, Gregory Brown, Lisa Durette, Timothy Ebright, Katie Cho

Psychiatry & Behavioral Health Faculty Research

Psychiatric practice is at a critical juncture in its evolution. Its identified model for understanding the complexity of individuals and their conditions has been the biopsycho-social-spiritual model since it was first proposed nearly half a century ago. In practice, this construct is being challenged by a biomedical model which asserts all psychiatric conditions can be reduced to either neurotransmitter or gene-based causation. We explore how models are used in science to approximate larger reality, with a focus on Systems Theory, which is the philosophical foundation for the bio-psycho-social-spiritual model to describe why this model is necessarily more complete than the …

The Effects Of Mosaic Law Observance On Human Health, Emily Uhlmeyer

Senior Honors Theses

For the people of ancient Israel, life was guided and regulated by adherence to the law of Moses. Dietary restrictions, purification rituals, circumcision, and Sabbath observance were each critical components of this code and were meticulously detailed in the Old Testament, specifically in the Torah. Still today, dietary laws are observed and select rituals practiced by many Jews and Seventh Day Adventists. Although health protection was never the primary purpose of the law, noticeable effects on human health have been connected to its observance. Evaluation of the effects of the Levitical law on human health can be achieved by a …

Improving Mental Health Among Undergraduate Nursing Students: Increasing Resilience In Nursing School, Hannah Hilliard

Senior Honors Theses

Nursing students face a unique set of obstacles during their time in school. Beyond the normal stressors of college life, they are required to spend several hours in the hospital per week, study for exams, and complete high acuity simulations, and they struggle with coping with these new demands. Undergraduate nursing students need to be supported in their mental health and coping strategies to improve their resilience in nursing school and, hence, their ability to function as a nurse in the future. This study has ascertained what students believe is helpful in supporting their mental health while in nursing school. …

Applications And Challenges Of Neural Stem Cell Therapy, John Brewster

Senior Honors Theses

In response to the many neurological disorders that plague humanity, no treatment shows more promise than stem cell therapy. By using these special cells to regrow damaged neurons and combat sources of disease in affected patients, researchers hope to treat neurological disorders of all kinds. While great strides have been made in laboratory settings, the widespread use of stem cells to treat neurological disorders in humans is still a distant goal. Recent advancements have been made in the area of neural stem cell therapy, but complications arise when using this method to treat neurological disorders.

The Pathogenesis Of Diabetes And Its Negative Impact On The Retina: Diabetic Retinopathy, Jonathan Nelson

Senior Honors Theses

Diabetic retinopathy causes the plurality of blindness among the working class of America. This review focuses on the biochemistry and pathophysiology of the pancreatic cells during the development of diabetes as well as the effects that diabetes has on the Müller cells and pericytes of the retina at the cellular and molecular levels. In addition, the current research on some of the treatment options for diabetic retinopathy will be presented. This review is valuable to the scientific community because it presents a side-by-side summary of the pathogenesis of diabetes and diabetic retinopathy based on the current body of research.

A Proposed Treatment Of Mixed Connective Tissue Disease By Competitive Inhibition Of Autoantibodies, Thomas Russell

Senior Honors Theses

Mixed Connective Tissue Disease is an autoimmune disease characterized by Raynaud’s phenomenon and arthritis among other symptoms. It is primarily caused by antibodies that target the U1-RNP 70K peptide. The treatment proposed in this paper uses competitive inhibition to prevent the binding of the anti-U1-RNP 70K antibodies with the U1-RNP 70K peptide. A method for testing the designed treatment in silico is proposed using AutoDock Vina docking software.

Jnk And Nf-Κb Cell Signaling Pathways In Cardiovascular Disease Present Potential Targets For Curcumin Therapy, Mary Richfield

Senior Honors Theses

Curcumin (diferuloylmethane) is a compound derived from the rhizomes of Curcumin longa that has been long used for medicinal purposes. Curcumin alleviates the pathology of cardiovascular diseases, including atherosclerosis, aneurysm, and cardiomyopathy. The mechanism of curcumin therapy is under active research. The NF-κB and JNK pathways are two that curcumin interacts with to block inflammatory processes, apoptosis, and fibrotic tissue remodeling to prevent the pathologies of cardiovascular disease. While curcumin has demonstrated powerful mediation of cardiovascular disease, its bioavailability in body tissues is limited due to the instability and hydrophobicity of its structure. Further work is underway to stabilize …

The Cutaneous Microbiome Of The Eastern Red-Spotted Newt (Notophthalmus Viridescens) And Its Role As Defense Against Fungal Pathogens, Joseph Bierbaum

Senior Honors Theses

Chytridiomycosis is a life-threatening disease which infects amphibian species worldwide. Chytrid fungi Batrachochytrium dendrobatidis (Bd) and Batrachochytrium salamandrivorans have been found to be the primary causes of chytridiomycosis. In past research, it has been found that the skin microbiome of certain amphibian species could have fungal inhibition properties, reducing the effects of the chytrid fungi. In this study, 15 eastern red-spotted newts (Notophthalmus viridescens) were collected, to determine if cutaneous bacteria of the newts secrete antifungal compounds. Pure cultures of each bacterium morphotype were produced from mass culture plates, with 188 morphotypes being isolated. The antifungal properties …

The Role Of Mtorc1 In Autophagy As It Relates To Cancer, Olivia Robinson

Senior Honors Theses

The mammalian target of rapamycin complex 1, mTORC1, is composed of several subunit proteins with many cellular responsibilities including participation in a complex cell signaling cascade leading to autophagy, which is the regulated degradation of cell components. mTORC1 is frequently mutated or dysregulated within human cancer. Normally, mTORC1 functions to provide efficient regulation of autophagy according to intracellular levels of growth factors, amino acids, nutrients, oxygen levels, and more that can either inhibit mTORC1 and upregulate autophagy or activate mTORC1 and downregulate autophagy. A better understanding of mTORC1 is imperative to preparing cancer therapy treatments. Various cancerous tissue types require …

Communicating Comfort In Crisis: A Literature Review On Overcoming The Emergency Room Environment To Foster The Nurse-Patient Relationship, Faith G. Davenport

Senior Honors Theses

The average emergency room patient is not receiving the compassionate nurse-patient communication that patients experience on other hospital floors. Fewer positive nurse-patient interactions prompt patients to state that they feel uncomforted and dissatisfied on hospital exit surveys, inciting hospital management to investigate how to reverse this trend to retain their federal funding. Emergency room nurses cite multiple barriers inherent in their work environment that prevent them from building rapport with their patients, including a layout not conducive to private conversations, strict time constraints, and a fluctuating workload. Working for a prolonged period under these conditions is driving many nurses to …

Hamstring And Quadriceps Strength Ratio In Collegiate Wrestlers, Jesse Redding

Senior Honors Theses

ACL injuries are a significant risk for athletes across sports. One of the sports that reports the highest rate of ACL injury is wrestling. The mechanism of injury among wrestlers appears to be unique and has limited data compared to other sports. Several nonmodifiable risk factors have been studied for ACL injury, as well as several modifiable risk factors that include BMI, muscular composition, and high-risk movements. The hamstring to quadriceps strength ratio (H:Q) is one aspect of muscular composition that has received little attention in collegiate wrestlers. The purpose of this study was to analyze the H:Q strength ratio …

Sleep Disruptions Within The Hospital, Faith Walls

Senior Honors Theses

The circadian rhythm is a complex and interwoven system within each human being that creates an internal clock each day. However, patients in all hospital settings continue to have their sleep disrupted by many factors. Seep being disrupted in the hospital patients can develop serious complications. To this day, the issues causing have not been adequately assessed and therapeutically intervened with consistency within nursing practice. Using the Whittemore and Knalf Framework, this integrative review will examine the literature on aspects of inpatient care that contribute to circadian disruptions within hospitals. By doing so, the research can be built upon with …