Medicine and Health Sciences Commons^™

Interprofessional Socialization Of Nursing Students After Participating In Interdisciplinary Rounds In An Intensive Care Unit, Ashlyn S. Upshaw

DNP Projects

Background: Nursing engagement in interprofessional collaboration leads to safe and quality healthcare for patients. In order to effectively engage in interprofessional collaboration, nursing students must socialize among healthcare providers from various disciplines. Purpose: The purpose of this project was to examine pre-licensure nursing students’ beliefs and attitudes towards interprofessional socialization and collaboration following their participation in interdisciplinary rounds in an intensive care unit (ICU) setting. Methods: A mixed-methods, cross-sectional design was used to collect data from undergraduate nursing students at a private university. Following an ICU clinical rotation, participants completed the Interprofessional Socialization and Valuing Survey-21 (ISVS-21) …

2022- The Twenty-Sixth Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Twenty-sixth Annual Symposium of Student Scholars, held on April 19, 2022. Includes abstracts from the presentations and posters.

An Examination Of The Relationship Between Childhood Punishment And Adult Ipv, Anna G. Griffith

Honors College Theses

The goal of this project is to examine the relationship between childhood punishment and experiencing intimate partner violence (IPV) as an adult. Using an anonymous, self-report survey, students from Georgia Southern University were asked about their experiences with IPV, as well as their experiences of childhood punishment administered by both mother and father. The results show that children who receive corporal, verbal, and emotional punishment from their mother are more likely to experience all forms of IPV later in life. When analyzing the same relationships with fathers, corporal punishment is not associated with IPV while verbal and emotional punishment is.

The Interrelationships Between Food Choice Motives, Food Insecurity, And Substance Use Among Us College Students, Natalie Nieschwitz

Honors Projects

Dietary quality declines during college and is exacerbated by food insecurity (FI) and substance use (SU), leading to negative health and academic consequences. Purposes of this study were to investigate rank importance of food choice motives (FCM), relationships between FI intensity and FCM, and relationships between SU intensity and FCM.

College students aged 18-30 were recruited by Facebook. The USDA 6-item Food Security Survey Module (FSSM); Alcohol Use Disorders Identification Test (AUDIT); Extended Drug Use Disorders Identification Test (DUDIT-E); and Food Choice Motives Questionnaire were used. FCM were analyzed using Friedman and Dunn-Bonferroni tests. Relationships between FCM and FI and …

Comprehensive Cross-Sectional And Longitudinal Analyses Of Plasma Neurofilament Light Across Ftd Spectrum Disorders, Tania F. Gendron, Nupur Ghoshal, Et Al.

2020-Current year OA Pubs

Frontotemporal dementia (FTD) therapy development is hamstrung by a lack of susceptibility, diagnostic, and prognostic biomarkers. Blood neurofilament light (NfL) shows promise as a biomarker, but studies have largely focused only on core FTD syndromes, often grouping patients with different diagnoses. To expedite the clinical translation of NfL, we avail ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) study resources and conduct a comprehensive investigation of plasma NfL across FTD syndromes and in presymptomatic FTD mutation carriers. We find plasma NfL is elevated in all studied syndromes, including mild cases; increases in presymptomatic mutation carriers prior to phenoconversion; and associates with …

Communities Helping The Hearing Of Infants By Reaching Parents (Chhirp) Through Patient Navigation: A Hybrid Implementation Effectiveness Stepped Wedge Trial Protocol, Matthew Bush, Miranda Hatfield, Marissa Schuh, Beverly K. Balasuriya, Anthony Mahairas, Julie Jacobs, Christina R. Studts, Philip M. Westgate, Nancy E. Schoenberg, Jennifer Shinn, Liza Creel

Otolaryngology--Head & Neck Surgery Faculty Publications

Introduction As the most common neonatal sensory disorder in the USA, infant hearing loss has an incidence of 1.7 per 1000 births. The consequences of delayed diagnosis and failure to obtain timely intervention include significant communication impairment and negative socioeconomic effects. Early Hearing Detection and Intervention (EHDI) national standards dictate that all infants should be screened and diagnosed by 3 months of age and there is a need for interventions that promote adherence to timely diagnosis. Patient navigation (PN) has been shown to be efficacious to decrease non-adherence with infant hearing diagnostic care; however, PN has yet to be tested …

Improvement Of Family Communication In The Perioperative Environment Utilizing Text Messaging, Sonja Orff, Kristiina Hyrkas

Costas T. Lambrew Research Retreat 2022

Text Messaging Technology Improves Patient Satisfaction for Communication with Nurses in Perioperative Care Unit

Training The Next Generation Of Translational Scientists: The Case Western Reserve University Translational Fellows Program, Cheryl L. Thompson, Tessianna A. Misko, Mark R. Chance

Faculty Scholarship

Background: An important part of biomedical research is the translation of discoveries into clinical or community applications that impact patient health. For a vast majority of clinical applications and sustainable community interventions, a time-tested way to get innovations to patients is through licensing of the technology and commercial development, often through startups. While biomedical scientists and trainees are schooled in discovery research, the processes of commercialization are foreign or intimidating. Further, many trainees will not aspire to a faculty position, and other avenues of advancement are desirable. Methods: At Case Western Reserve University, we developed and launched a Translational Fellows …

Home And Environmental Modifications And Community Resources For Individuals With Visual Impairment, Kimberly Mclaughlin

OTD Capstone Projects

Tucker's House is a non-profit organization that provides home and environmental modifications as well as assistive devices to families in Middle Tennessee that have a child with a disability. This doctoral capstone project focused on developing resources the organization can provide to individuals with low vision, visual impairment or blindness as well as their families/caregivers. The resources created include family intake forms, adaptive devices and durable medical equipment lists, community resources, general strategies, and smartphone/technology accessibility guides all related to increasing safety, participation in daily living tasks, and independence for individuals with visual impairment.

Mental Disorder Symptoms During The Covid-19 Pandemic In Latin America – A Systematic Review And Meta-Analysis, Stephen X. Zhang, Kavita Batra, Wen Xu, Tao Liu, Rebecca Kechen Dong, Allen Yin, Andrew Yilong Delios, Bryan Z. Chen, Richard Z. Chen, Saylor Miller, Xue Wan, Wenping Ye, Jiyao Chen

School of Medicine Faculty Research

Aims There is a lack of evidence related to the prevalence of mental health symptoms as well as their heterogeneities during the coronavirus disease 2019 (COVID-19) pandemic in Latin America, a large area spanning the equator. The current study aims to provide meta-analytical evidence on mental health symptoms during COVID-19 among frontline healthcare workers, general healthcare workers, the general population and university students in Latin America. Methods Bibliographical databases, such as PubMed, Embase, Web of Science, PsycINFO and medRxiv, were systematically searched to identify pertinent studies up to August 13, 2021. Two coders performed the screening using predefined eligibility criteria. …

Fortunate People In A Fortunate Land: Dwelling And Residential Alienation In Santa Monica's Rent-Controlled Housing, Lauren E.M. Everett

Dissertations and Theses

The importance of safe and stable housing for individual and community wellbeing is widely acknowledged. However, for the one third of Americans who rent their homes, housing-related stress and precarity (residential alienation) may undermine stability and a sense of home. Rent control is perhaps the most well-known tenant protection policy in the United States, but it remains highly controversial and its efficacy has been debated for decades. This research is the first academic inquiry to examine the policy through the experience of residents of rent-controlled housing. In academic discourse dominated by quantitative inquiry from the discipline of economics, this study …

Exploring The Gap: Positive And Negative Experiences Of The Clinical Nurse Educator, Ariana Johnson

Honors Theses

The overall aim of this thesis is to understand clinical nurse educator experiences. Challenges to retain and recruit nurse educators' limits nursing student enrollment and the ability to meet nursing workforce demands. The American Association of Colleges of Nursing (AACN) factors contributing to nursing faculty shortages guided this thesis research study. Asking research questions, “Describe what you like about being an academic clinical nurse educator” and “Describe what you don’t like about being an academic clinical nurse educator” can support understanding clinical nurse educator positive and negative experiences. A qualitative descriptive study and thematic analysis was conducted. An anonymous 22-question …

Crossing The Border: A Novel Mouse Line Using Fgf10-Cre To Drive Gata3 Overexpression In Nonsensory Transcriptional Context, Lucas Cunha

Honors Theses

Hearing loss can occur in a variety of ways, and in every case, they have equally devasting effects. While hearing loss and the people who suffer from it shall not be discriminated against, attempting to offer options for treatments nevertheless should be of priority. As such, there has been much progress in the field of genetically based forms of treatment for sensorineural hearing loss. A gene that has been almost always implicated in the conversation of regeneration, Hair Cell and Spiral Ganglia development, and inner ear development, in general, is the Zing Finger transcription factorsGata3. Furthermore, since the Organ of …

Successful Components For Developing An Oncology Nurse Residency Program: An Integrative Review, Andi Johnson

Master of Science in Nursing Final Projects

Problem Identification

Residency programs for newly licensed registered nurses (NLRNs) have become an integral part of the new nurse’s transition to professional practice, improving resilience and retention of the NLRN. The goal of this integrative review is to highlight concepts and components that have been successfully incorporated into NLRN residencies and provide nursing leaders with actionable guidance to incorporate into facility-based oncology nurse residencies.

Literature Search

An integrative review using Whittemore and Knafl’s approach was conducted in accordance with principles of thematic analysis established by Toronto and Remington.

Data Evaluation

Eighteen records were included. As few research articles were found …

Exercise Education Of Western Michigan University Students Who Use The University Recreation Center, Rachael Brewer

Honors Theses

According to the American College of Sports Medicine’s (ACSM) annual survey data, various modalities of resistance training are reported in the top 20 ways to exercise in 2022. According to the Nationwide Children’s Hospital, there has been a significant increase in acute care visits resulting from resistance training as it becomes more common to train without proper professional oversight (Nationwide Children’s Hospital, 2010). Many exercisers watch, replicate, or take advice from friends in the weight room; however, professional instruction is key for a safe workout experience. Injuries can and do occur on resistance machines, treadmills, and stair mills with little …

Reduced Er-Mitochondria Connectivity Promotes Neuroblastoma Multidrug Resistance., Jorida Çoku, David M. Booth, Jan Skoda, Madison C Pedrotty, Jennifer Vogel, Kangning Liu, Annette Vu, Erica L Carpenter, Jamie C Ye, Michelle A Chen, Peter Dunbar, Elizabeth Scadden, Taekyung D Yun, Eiko Nakamaru-Ogiso, Estela Area-Gomez, Yimei Li, Kelly C Goldsmith, C Patrick Reynolds, György Hajnóczky, Michael D Hogarty

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Most cancer deaths result from progression of therapy resistant disease, yet our understanding of this phenotype is limited. Cancer therapies generate stress signals that act upon mitochondria to initiate apoptosis. Mitochondria isolated from neuroblastoma cells were exposed to tBid or Bim, death effectors activated by therapeutic stress. Multidrug-resistant tumor cells obtained from children at relapse had markedly attenuated Bak and Bax oligomerization and cytochrome c release (surrogates for apoptotic commitment) in comparison with patient-matched tumor cells obtained at diagnosis. Electron microscopy identified reduced ER-mitochondria-associated membranes (MAMs; ER-mitochondria contacts, ERMCs) in therapy-resistant cells, and genetically or biochemically reducing MAMs in therapy-sensitive …

Editorial: Special Issue “Innovative Techniques And Approaches In The Control And Prevention Of Rabies Virus”, Amy T. Gilbert, Ryan M. Wallace, Charles E. Rupprecht

United States Department of Agriculture Wildlife Services: Staff Publications

Rabies is an ancient lethal scourge that has plagued humankind for centuries. Globally, 60,000 human deaths are estimated to occur each year from rabies virus (RABV) transmission in domestic dogs, mostly affecting children. While rabies is recognized as a neglected disease, there is cause for optimism in the context of growing global recognition, collaboration and commitment to advance a tripartite agenda to eliminate human deaths transmitted from rabid dogs by 2030, also known as “Zero By Thirty” (ZBT). Nevertheless, the ZBT goal must also confront competing challenge(s) of tracking and mitigating human morbidity and mortality during a global pandemic caused …

Relationship Between Age At Menopause, Obesity, And Incident Heart Failure: The Atherosclerosis Risk In Communities Study, Imo A Ebong, Machelle D Wilson, Duke Appiah, Erin D Michos, Susan B Racette, Amparo Villablanca, Khadijah Breathett, Pamela L Lutsey, Melissa Wellons, Karol E Watson, Patricia Chang, Alain G Bertoni

2020-Current year OA Pubs

Background The mechanisms linking menopausal age and heart failure (HF) incidence are controversial. We investigated for heterogeneity by obesity on the relationship between menopausal age and HF incidence. Methods and Results Using postmenopausal women who attended the Atherosclerosis Risk in Communities Study Visit 4, we estimated hazard ratios of incident HF associated with menopausal age using Cox proportional hazards models, testing for effect modification by obesity and adjusting for HF risk factors. Women were categorized by menopausal age: <45 years, 45 to 49 years, 50 to 54 years, and ≥55 years. Among 4441 postmenopausal women, aged 63.5±5.5 years, there were 903 incident HF events over a mean follow-up of 16.5 years. The attributable risk of generalized and central obesity for HF incidence was greatest among women who experienced menopause at age ≥55 years: 11.09/1000 person-years and 7.38/1000 person-years, respectively. There were significant interactions of menopausal age with body mass index and waist circumference for HF incidence,

Need For Better And Broader Training In Cardio-Obstetrics: A National Survey Of Cardiologists, Cardiovascular Team Members, And Cardiology Fellows In Training, Natalie A Bello, Akanksha Agrawal, Melinda B Davis, Colleen M Harrington, Kathryn J Lindley, Margo B Minissian, Garima Sharma, Mary Norine Walsh, Ki Park

2020-Current year OA Pubs

Background Team-based models of cardio-obstetrics care have been developed to address the increasing rate of maternal mortality from cardiovascular diseases. Cardiovascular clinician and trainee knowledge and comfort with this topic, and the extent of implementation of an interdisciplinary approach to cardio-obstetrics, are unknown. Methods and Results We aimed to assess the current state of cardio-obstetrics knowledge, practices, and services provided by US cardiovascular clinicians and trainees. A survey developed in conjunction with the American College of Cardiology was circulated to a representative sample of cardiologists (N=311), cardiovascular team members (N=51), and fellows in training (N=139) from June 18, 2020, to …

Temporal Trends In Outcomes In Patients With Adrenocortical Carcinoma: A Multidisciplinary Referral-Center Experience, Marilyne Daher, Jeena Varghese, Stephen K Gruschkus, Camilo Jimenez, Steven G Waguespack, Sara Bedrose, Lina Altameemi, Hadil Bazerbashi, Aung Naing, Vivek Subaiah, Matthew T Campbell, Amishi Y Shah, Miao Zhang, Rahul A Sheth, Jose A Karam, Christopher G Wood, Nancy D Perrier, Paul H Graham, Jeffery E Lee, Mouhammed Amir Habra

Faculty, Staff and Students Publications

CONTEXT: Reporting temporal trends in adrenocortical carcinoma (ACC) helps guide management strategies.

OBJECTIVE: This work aimed to report the trends in disease burden and clinical outcomes over time that cannot be adequately captured from individual clinical trials.

METHODS: A retrospective study was held of ACC patients seen at a referral cancer center between February 1998 and August 2019. Clinical outcomes were compared between an early cohort (February 1998-June 2007) and a late cohort (July 2007-August 2019).

RESULTS: A total of 621 patients included with a median age at diagnosis of 49.3 years (range, 0.5-86.6 years). There were 285 (45.9%) patients …

Hyperactivation Is Sufficient To Release Porcine Sperm From Immobilized Oviduct Glycans, Momal Sharif, Vincent Hickl, Gabriel Juarez, Xingjian Di, Karl Kerns, Peter Sutovsky, Nicolai Bovin, David J Miller

Faculty, Staff and Students Publications

Fertilizing sperm are retained by adhesion to specific glycans on the epithelium of the oviduct forming a reservoir before sperm are released from the reservoir so fertilization can ensue. Capacitated sperm lose affinity for the oviduct epithelium but the components of capacitation that are important for sperm release are uncertain. One important correlate of capacitation is the development of hyperactivated motility. Hyperactivation is characterized by asymmetrical flagellar beating with high beat amplitude. We tested whether the development of full-type asymmetrical motility was sufficient to release sperm from immobilized oviduct glycans. Sperm hyperactivation was induced by four different compounds, a cell-permeable …

Centrosome-Dependent Microtubule Modifications Set The Conditions For Axon Formation, Durga Praveen Meka, Ewelina Betleja, Tao Cheng, Moe R Mahjoub, Et Al.

2020-Current year OA Pubs

Microtubule (MT) modifications are critical during axon development, with stable MTs populating the axon. How these modifications are spatially coordinated is unclear. Here, via high-resolution microscopy, we show that early developing neurons have fewer somatic acetylated MTs restricted near the centrosome. At later stages, however, acetylated MTs spread out in soma and concentrate in growing axon. Live imaging in early plated neurons of the MT plus-end protein, EB3, show increased displacement and growth rate near the MTOC, suggesting local differences that might support axon selection. Moreover, F-actin disruption in early developing neurons, which show fewer somatic acetylated MTs, does not …

Iron Effects On Clostridioides Difficile Toxin Production And Antimicrobial Susceptibilities, Jason Yamaki, Swati Chawla, Shirley Tong, Kate Alison Lozada, Sun Yang

Pharmacy Faculty Articles and Research

Despite the benefits of red blood cell (RBC) transfusion therapy, it can render patients vulnerable to iron overload. The excess iron deposits in various body tissues cause severe complications and organ damage such as cardiotoxicity and mold infections. Clostridioides difficile infection (CDI) is the most common cause of nosocomial diarrhea among cancer patients and is associated with significant morbidity and mortality. Our study aims to determine the role of iron overload and the effects of iron chelators on CDI. Our results demonstrated that iron (Fe³⁺) stimulated the growth of C. difficile with increased colony formation units (CFU) in …

Safety And Efficacy Of Systemic Anti-Scg3 Therapy To Treat Oxygen-Induced Retinopathy, Chang Dai, Hong Tian, Amit Bhatt, Guanfang Su, Keith A Webster, Wei Li

Faculty, Staff and Students Publications

BACKGROUND: To circumvent possible systemic side effects, anti-angiogenic drugs targeting vascular endothelial growth factor (VEGF) for ocular neovascular diseases in adults are approved only for intravitreal administration. However, intravitreal injection itself can elicit injection-related adverse effects, and premature eyes of infants with retinopathy of prematurity (ROP) may be particularly susceptible to intravitreal injection. Therefore, an unmet clinical need is to develop safe systemic anti-angiogenic therapies for ROP. We recently reported that secretogranin III (Scg3) is a disease-restricted angiogenic factor and that systemic anti-Scg3 mAb alleviates ROP in animal models with minimal side effects on developing eyes and organs. The aim …

Safety And Efficacy Of Systemic Anti-Scg3 Therapy To Treat Oxygen-Induced Retinopathy, Chang Dai, Hong Tian, Amit Bhatt, Guanfang Su, Keith A Webster, Wei Li

Faculty, Staff and Students Publications

BACKGROUND: To circumvent possible systemic side effects, anti-angiogenic drugs targeting vascular endothelial growth factor (VEGF) for ocular neovascular diseases in adults are approved only for intravitreal administration. However, intravitreal injection itself can elicit injection-related adverse effects, and premature eyes of infants with retinopathy of prematurity (ROP) may be particularly susceptible to intravitreal injection. Therefore, an unmet clinical need is to develop safe systemic anti-angiogenic therapies for ROP. We recently reported that secretogranin III (Scg3) is a disease-restricted angiogenic factor and that systemic anti-Scg3 mAb alleviates ROP in animal models with minimal side effects on developing eyes and organs. The aim …

Protocol For An Ehub As An Systemic Intervention For Homeless Shelter Staff And Resident Psychosocial And Behavioral Needs, Celeste Sangiorgio, Cory Crane, Cassandra Berbery, Caroline Easton

Frameless

Homeless shelter performance is presently operationalized as shelter success in linking homeless individuals to housing; however, there is a cluster of individuals with co-occurring serious mental health issues who engage in chronic and episodic re-entry into homeless shelters. Persistent and chronically mentally ill individuals who re-enter shelters increase demands on staff, who are inadequately trained to de- escalate, manage their internal distress, and connect these homeless residents to appropriate services. This protocol outlines an alternative intervention mechanism for shelters that targets a key, untreated pathway where staff and resident symptoms and skills are linked to shelter performance. We propose that …

Simulating Implant Procedures In Dentistry, Brandon Patterson

Frameless

The School of Dentistry in partnership with the health sciences library at the University of Utah developed VR simulations for dental implants. The benefits of using the technology included providing endless scenarios, evaluation measures, and experiential learning experiences for students [1]. The school administration found that the simulations kept pace with the requirements of regulatory authorities, helped reduce costs in dental education, and found that students who trained in VR scored significantly better than traditional methods largely due to their ability to repeat tasks and receive instant feedback [2, 3].

Designing A Digital Interactive Emotion Measure (Diem) For Digital Media: Theoretical Foundations And Validation Protocols, Celeste Sangiorgio, Cassandra Berbary, Cory Crane, Caroline Easton

Frameless

Awareness of emotions is often a treatment target in psychotherapy, but it is difficult to assess emotions due to ambiguity in measurement or scale design. Lack of clarity in scale design may increase risk that participant interpretations of scale items may not align with emotion constructs those scales were designed to capture. Furthermore, emphasis on verbal or written cues leads to low scientific representation of patients who cannot read emotion scales (e.g., low literacy). Touch-screen applications provide a unique opportunity to create a visual emotion measure which has low barriers but can be used to assess a high level of …

Use Of Ar To Bring Medical Simulation To Life, Zhenhua Yu, Richard L. Doolittle, Caroline J. Easton

Frameless

Use of simulation facilities and equipment in medical training has become the fabric of curricula across nearly all professions, most notably medical school, nursing, and related medical sciences programs. The gold standard for simulators is SimMan3G, Laerdal Inc., which offers a static electronic mannequin that affords the opportunity to create disease states, signs/symptoms, and real physiological/vital sign data complemented by voice interactions between faculty (within the control room) and student. All sessions are videotaped and, through a 15-30 minute debriefing, students exchange thoughts and impressions with faculty and engage in a deep reflective learning experience. The other option for medical …

Can We Walk In Our Patients’ Shoes? Immersive Virtual Reality As An Empathy Training Tool For Medical Students, Riham Alieldin, Raffaella Borasi, Anne Nofziger, Karen Deangelis, Sarah Peyre

Frameless

Empathy is arguably the “backbone” of the patient-physician relationship. It has been shown to have numerous positive clinical outcomes especially in a patient-centered careservice. Nevertheless, studies have shown a disintegration of empathy and compassion in physicians during medical school and residency training due to the lack of standardization of empathy training in medical education.