Medicine and Health Sciences Commons^™

Ibrutinib Attenuated Dss-Induced Ulcerative Colitis, Oxidative Stress, And Inflammatory Cascade By Modulating Pi3k/Akt And Jnk/Nfκb Pathways, Liangliang Hao, Lina Tariq Alkury, Abdullah Alattar, Muhammad Faheem, Reem Alshaman, Fawad Ali Shah, Shupeng Li

All Works

No abstract provided.

Venetoclax Combinations Delay The Time To Deterioration Of Hrqol In Unfit Patients With Acute Myeloid Leukemia, Keith W Pratz, Panayiotis Panayiotidis, Christian Recher, Xudong Wei, Brian A Jonas, Pau Montesinos, Vladimir Ivanov, Andre C Schuh, Courtney D Dinardo, Jan Novak, Vlatko Pejsa, Don Stevens, Su-Peng Yeh, Inho Kim, Mehmet Turgut, Nicola Fracchiolla, Kazuhito Yamamoto, Yishai Ofran, Andrew H Wei, Cat N Bui, Katy Benjamin, Rajesh Kamalakar, Jalaja Potluri, Wellington Mendes, Jacob Devine, Walter Fiedler

Faculty, Staff and Student Publications

Phase 3 trials Viale-A and Viale-C evaluated health-related quality of life (HRQoL) in patients with AML unfit for intensive chemotherapy who received venetoclax (VEN) + (AZA) (Viale-A) or low-dose cytarabine (LDAC) (Viale-C) or placebo (PBO) + AZA or LDAC. Patient-reported outcomes included: EORTC QLQ-C30 global health status (GHS/QoL) and physical functioning (PF), PROMIS Cancer Fatigue Short Form 7a (Fatigue), and EQ-5D-5L health status visual analog scale (HS-VAS). Time to deterioration (TTD), defined as worsening from baseline in meaningful change thresholds (MCT) of ≥10, 5, or 7 points for GHS/QoL or PF, fatigue, and HS-VAS, respectively, was assessed; differences between groups …

Pnc-27, A Chimeric P53-Penetratin Peptide Binds To Hdm-2 In A P53 Peptide-Like Structure, Induces Selective Membrane-Pore Formation And Leads To Cancer Cell Lysis, Ehsan Sarafraz-Yazdi, Stephen Mumin, Diana Cheung, Daniel Fridman, Brian Lin, Lawrence Wong, Ramon Rosal, Rebecca Rudolph, Matthew Frenkel, Anusha Thadi, William F. Morano, Wilbur B. Bowne, Matthew R. Pincus, Josef Michl

Department of Surgery Faculty Papers

PNC-27, a 32-residue peptide that contains an HDM-2 binding domain and a cell-penetrating peptide (CPP) leader sequence kills cancer, but not normal, cells by binding to HDM-2 associated with the plasma membrane and induces the formation of pores causing tumor cell lysis and necrosis. Conformational energy calculations on the structure of PNC-27 bound to HDM-2 suggest that 1:1 complexes form between PNC-27 and HDM-2 with the leader sequence pointing away from the complex. Immuno-scanning electron microscopy was carried out with cancer cells treated with PNC-27 and decorated with an anti-PNC-27 antibody coupled to 6 nm gold particles and an anti-HDM-2 …

Targeted Therapy In The Management Of Modern Craniopharyngiomas, Maikerly Reyes, Mohammad Taghvaei, Siyuan Yu, Anish Sathe, Sarah Collopy, Giyarpuram Prashant, James J. Evans, Michael Karsy

Department of Neurosurgery Faculty Papers

Background: The proximity of craniopharyngiomas (CPs) to critical neurovascular structures can lead to a host of neurologic and endocrine complications that lead to difficulty with surgical management. In this review, we examine the molecular and genetic markers implicated in CP, their involvement in tumorigenic pathways, and their impact on CP prognosis and treatment.

Methods: We undertook a focused review of relevant articles, clinical trials, and molecular summaries regarding CP.

Results: Genetic and immunological markers show variable expression in different types of CP. BRAF is implicated in tumorigenesis in papillary CP (pCP), whereas CTNNB1 and EGFR are often overexpressed in adamantinomatous …

Impact Of Interleukin-34 On The Promotion Of Bone Osteolysis And Neuroinflammation In Experimental Models Of Alzheimer’S Disease, Anny Ho

All HCAS Student Capstones, Theses, and Dissertations

Alzheimer’s disease (AD) is a growing health concern and is the most common type of dementia worldwide. Emerging evidence indicates that aggregated amyloid-beta (Aβ) peptides, one of the hallmark features of AD neuropathology, can increase RANKL-mediated osteoclast activity leading to the prevalence and severity of inflammatory osteolysis, e.g., osteoporosis and periodontal bone loss. Conversely, osteolytic lesions are associated with increased risk of dementia diagnosis indicating that there is a direct link between dementia and inflammatory osteolysis. It was demonstrated that the neuronal cells primarily produce interleukin-34 (IL-34) and microglia, macrophages, and osteoclast precursors express colony-stimulating factor 1 receptor (CSF-1R), a …

Dynamics Of Huntingtin Protein Interactions In The Striatum Identifies Candidate Modifiers Of Huntington Disease, Todd M Greco, Christopher Secker, Eduardo Silva Ramos, Joel D Federspiel, Jeh-Ping Liu, Alma M Perez, Ismael Al-Ramahi, Jeffrey P Cantle, Jeffrey B Carroll, Juan Botas, Scott O Zeitlin, Erich E Wanker, Ileana M Cristea

Duncan NRI Faculty and Staff Publications

Huntington’s disease (HD) is a monogenic neurodegenerative disorder with one causative gene, huntingtin (HTT). Yet, HD pathobiology is multifactorial, suggesting that cellular factors influence disease progression. Here, we define HTT protein-protein interactions (PPIs) perturbed by the mutant protein with expanded polyglutamine in the mouse striatum, a brain region with selective HD vulnerability. Using metabolically labeled tissues and immunoaffinity purification-mass spectrometry, we establish that polyglutamine-dependent modulation of HTT PPI abundances and relative stability starts at an early stage of pathogenesis in a Q140 HD mouse model. We identify direct and indirect PPIs that are also genetic disease modifiers using in-cell two-hybrid …

A Proposed Role For Interactions Between Argonautes, Mirisc, And Rna Binding Proteins In The Regulation Of Local Translation In Neurons And Glia, Sarah K Koester, Joseph D Dougherty

2020-Current year OA Pubs

The first evidence of local translation in the CNS appeared nearly 40 years ago, when electron microscopic studies showed polyribosomes localized to the base of dendritic spines. Since then, local translation has been established as an important regulatory mechanism for gene expression in polarized or functionally compartmentalized cells. While much attention has been placed on characterizing the local transcriptome and regulatory "grammar" directing mRNA localization in neurons and glia, less is understood about how these cells subsequently de-repress mRNA translation in their peripheral processes to produce a rapid translational response to stimuli. MicroRNA-mediated translation regulation offers a possible solution to …

Calgb 40603 (Alliance): Long-Term Outcomes And Genomic Correlates Of Response And Survival After Neoadjuvant Chemotherapy With Or Without Carboplatin And Bevacizumab In Triple-Negative Breast Cancer, Jonathan H Shepherd, Cynthia Ma, Et Al.

2020-Current year OA Pubs

PURPOSE: CALGB 40603 (NCT00861705), a 2 × 2 randomized phase II trial, demonstrated that adding carboplatin or bevacizumab to weekly paclitaxel (wP) followed by doxorubicin and cyclophosphamide significantly increased the pathologic complete response (pCR) rate in stage II-III triple-negative breast cancer. We now report long-term outcomes (LTOs) and correlative science end points.

PATIENTS AND METHODS: The Kaplan-Meier method was used to estimate LTOs in 443 patients who initiated study treatment. Log-rank tests and Cox proportional hazards models evaluated the impact of clinical characteristics, pathologic response, calculated residual cancer burden (RCB) in patients with residual disease (RD), treatment assignment, and dose …

Dancing With 4e Cognitive Science And Human Science Psychology, Joshua Hall

Middle Voices

According to the “Embodied Cognition” entry in the Stanford Encyclopedia of Philosophy, the three landmark texts in the 4E cognitive science tradition are Lakoff and Johnson’s Metaphors We Live By, Varela, Thompson, and Rosch’s The Embodied Mind, and Andy Clark’s Being There. In my first section, I offer a phenomenological interpretation of these three texts, identifying recuring affirmations of the figure of dance alongside explicit marginalization of the practice of dance, perhaps in part due to cognitive science’s overemphasis on cognition to the exclusion of affect. In my second section, drawing on my previous interpretations of proto-affect theorists …

Orthodontic Treatment Of Severe Bimaxillary Dentoalveolar Protrusion With Skeletal Class Ii Malocclusion Without Using Miniscrews, Yi-Wei Huang, Chun-Liang Kuo, I-Hua Liu, Yu-Ling Tsai, Chung-Li Wang, Chun-Hsiu Yang

Taiwanese Journal of Orthodontics

Bimaxillary dentoalveolar protrusion is characterized by the proclined anterior teeth, protrusive lips, and a convex profile. A proper orthodontic treatment modality for efficient anchorage control is necessary to retract the anterior teeth and improve the facial esthetics significantly. The commonly used miniscrew could provide absolute anchorage, however, it is accompanied by some risks and complications, especially in adolescent females. This case report described a 16-year-old female with diagnosis of skeletal Class II, normal mandibular plane angle, and Angle Class I malocclusion associated with proclined upper and lower anterior teeth, excessive overjet, and a convex profile with lip incompetence. We extracted …

Surgical-Orthodontic Treatment Of Skeletal Class Ii Malocclusion With Obstructive Sleep Apnea And Multiple Missing Teeth, Ching-Yi Lee, Chung-Yi Ho, Cheng-Hui Lin, Ellen Wen-Ching Ko

Taiwanese Journal of Orthodontics

In the treatment of skeletal Class II retrognathic mandible, the airway should be considered for the progress and outcome of the treatment. The case report demonstrates combined orthodontic and orthognathic surgery in a 39-year-old woman with chief complaint of maxillary protrusion. The clinical examination and X-ray revealed skeletal Class II with a retrognathic mandible, high mandibular plane, vertical maxillary excess (VME), bilateral deformed condyles, and narrow posterior airway space. Moreover, the patient had several missing teeth with a posterior lingual crossbite. Polysomnography revealed obstructive sleep apnea (OSA), with a high apnea–hypopnea index (AHI) of 12.1/h. Her body mass index was …

Tripod Mandibular Advancement Surgery Used In A Class Ii Malocclusion With Receding Lower Jaw, Yu-Ting Wang, Yu-Ling Cheng, Ming-Jeaun Su, Huei-Mei Tsai, Yi-Min Liu

Taiwanese Journal of Orthodontics

This report concerns a relatively simple and reliable method of managing a case of maxillary dental malocclusion combined with a minor underdeveloped and receding mandible.

The chief complaint of the patient was crowded upper anterior teeth and receding chin. After a thorough examination, the patient was diagnosed with a relatively normal maxilla with a slightly small mandible. Impacted upper left canine and missing lower central incisors were noted.

The main treatment goal was to combine surgery and orthodontics to gain the most benefit of treatment. Tripod mandibular advancing surgery (TMAS) plus genioplasty was used as a single-jaw intervention. Orthodontic mechanotherapy, …

Angle Class Ii Division 1 Malocclusion In An Adolescent Patient Treated With Four First Premolars Extraction And Temporary Anchorage Devices, Yu-Cheng Hsu, Po-Yu Yang, Chia-Tze Kao

Taiwanese Journal of Orthodontics

This case report describes a successful orthodontic treatment in an Angle Class II division 1 malocclusion with severe space deficiency by temporary anchorage device (TAD) in a 15-year-old male patient. The skeletal analysis showed mandibular retrognathism and slightly hyperdivergent growth pattern. The treatment plan included four first premolars extractions combined with TAD application which used for anteroposterior and vertical anchorage control. The orthodontic treatment was to achieve the effect of counter-clockwise rotation of mandible for the patient who still has remaining growth. After 23 months of orthodontic treatment, Angle Class I molar relationship was achieved. The patient was satisfied with …

Open Bite: A Clinical Challenge For The Orthodontist (Part Ii), Ib Leth Nielsen

Taiwanese Journal of Orthodontics

Treatment of anterior open bite presents numerous challenges to the orthodontists. Should an open bite be treated early, or should it be delayed until most growth has been completed is just one of the many questions? Can treatment be done with conventional orthodontics or is a combination of orthodontics and orthognathic surgery indicated? Anterior open bite can develop later in life because of idiopathic condylar resorption, excess mandibular growth, and by iatrogenic causes. This article will discuss both normal and pathological developments and the possible treatment approaches. The importance of understanding the etiology of open bite and address the causes …

Open Bite: A Clinical Challenge For The Orthodontist (Part I), Ib Leth Nielsen

Taiwanese Journal of Orthodontics

The open bite malocclusion is challenging to most orthodontists in part because the etiology is poorly understood. In this review we will explain the multifactorial etiology of this malocclusion. The role of facial growth and function in the development of this malocclusion, and several other factors that often are contributing to this malocclusion. The etiology, diagnosis and some important treatment considerations in patients with open bite will be discussed.

Independent Study Curriculums For Adult Students With Idd At Lipscomb University - Ideal, Megan Roman

OTD Capstone Projects

Independent study curriculums targeting independent living skills for adults with intellectual and/or developmental disabilities attending the Igniting the Dream of Education and Access at Lipscomb (IDEAL) program. The curriculum was created using the constructivism model and social cognitive theory for an active approach to learning that promotes self-efficacy in independent living skills to facilitate student success within the program and upon their transition into the community.

2022-04-19_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/data-about-places/long-term-care-data.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …

Advocacy And Collaboration To Promote And Enhance Services Provided By Ability App, Callie Emerson

OTD Capstone Projects

This poster details advocacy effort made to promote Ability App to healthcare students in Bloomington, Indiana in hopes of increasing accessibility for individuals with disabilities, educating future healthcare professionals, and encouraging individuals in Bloomington to use Ability App.

Evaluating Accessibility In Tn State Parks, Ashley C. Phillips

OTD Capstone Projects

During this Capstone experience, I partnered with Tucker's House and the TN State Parks to evaluate the efficacy of the State Park ADA Assessment tool. After modifying the assessment tool, I evaluated the three most visited state parks in TN and made suggestions on how to improve accessibility of the parks.

Comparative Transmissibility Of Sars-Cov-2 Variants Delta And Alpha In New England, Usa., Rebecca Earnest, Rockib Uddin, Nicholas Matluk, Nicholas Renzette, Sarah E Turbett, Katherine J Siddle, Christine Loreth, Gordon Adams, Christopher H Tomkins-Tinch, Mary E Petrone, Jessica E Rothman, Mallery I Breban, Robert Tobias Koch, Kendall Billig, Joseph R Fauver, Chantal B F Vogels, Kaya Bilguvar, Bony De Kumar, Marie L Landry, David R Peaper, Kevin Kelly, Greg Omerza, Heather Grieser, Sim Meak, John Martha, Hannah B Dewey, Susan Kales, Daniel Berenzy, Kristin Carpenter-Azevedo, Ewa King, Richard C Huard, Vlad Novitsky, Mark Howison, Josephine Darpolor, Akarsh Manne, Rami Kantor, Sandra C Smole, Catherine M Brown, Timelia Fink, Andrew S Lang, Glen R Gallagher, Virginia E Pitzer, Pardis C Sabeti, Stacey Gabriel, Bronwyn L Macinnis, New England Variant Investigation Team, Ryan Tewhey, Mark D Adams, Daniel J Park, Jacob E Lemieux, Nathan D Grubaugh

Faculty Research 2022

The SARS-CoV-2 Delta variant rose to dominance in mid-2021, likely propelled by an estimated 40%-80% increased transmissibility over Alpha. To investigate if this ostensible difference in transmissibility is uniform across populations, we partner with public health programs from all six states in New England in the United States. We compare logistic growth rates during each variant's respective emergence period, finding that Delta emerged 1.37-2.63 times faster than Alpha (range across states). We compute variant-specific effective reproductive numbers, estimating that Delta is 63%-167% more transmissible than Alpha (range across states). Finally, we estimate that Delta infections generate on average 6.2 (95% …

Functional Elements Of The Cis-Regulatory Lincrna-P21., Lauren Winkler, Maria Jimenez, Joshua T Zimmer, Adam Williams, Matthew D Simon, Nadya Dimitrova

Faculty Research 2022

The p53-induced long noncoding RNA (lncRNA) lincRNA-p21 is proposed to act in cis to promote p53-dependent expression of the neighboring cell cycle gene, Cdkn1a/p21. The molecular mechanism through which the transcribed lincRNA-p21 regulatory locus activates p21 expression remains poorly understood. To elucidate the functional elements of cis-regulation, we generate a series of genetic models that disrupt DNA regulatory elements, the transcription of lincRNA-p21, or the accumulation of mature lincRNA-p21. Unexpectedly, we determine that full-length transcription, splicing, and accumulation of lincRNA-p21 are dispensable for the chromatin organization of the locus and for cis-regulation. Instead, we find that production of lincRNA-p21 through …

2022 April 19 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

The Effect Of Self-Management Support Interventions For Adults With Mild Traumatic Brain Injury And Family Caregivers, Ann Thaiudom

Dissertations

Purpose: This study aimed to examine the effect of a self-management support program for individuals with mild traumatic brain injury (mTBI) and their family caregivers.

Design: The study design was a two-group randomized control trial.

Method: A total of 73 mTBI patients and their primary family caregivers were randomly assigned to either the intervention group (n=36) receiving the self-management support program plus usual care or the control group (n=37) receiving only usual care. The self-management program was developed based on the Individual and Family Self-management theory, and relevant clinical practice guidelines. The program consisted of self-management support assessment at …

Hereditary Retinoblastoma Ipsc Model Reveals Aberrant Spliceosome Function Driving Bone Malignancies, Jian Tu, Zijun Huo, Yao Yu, Dandan Zhu, An Xu, Mo-Fan Huang, Ruifeng Hu, Ruoyu Wang, Julian A Gingold, Yi-Hung Chen, Kuang-Lei Tsai, Nicolas R Forcioli-Conti, Sarah X L Huang, Thomas R Webb, Jie Su, Danielle A Bazer, Peilin Jia, Jason T Yustein, Lisa L Wang, Mien-Chie Hung, Zhongming Zhao, Chad D Huff, Jingnan Shen, Ruiying Zhao, Dung-Fang Lee

Faculty, Staff and Student Publications

The RB1 gene is frequently mutated in human cancers but its role in tumorigenesis remains incompletely defined. Using an induced pluripotent stem cell (iPSC) model of hereditary retinoblastoma (RB), we report that the spliceosome is an up-regulated target responding to oncogenic stress in RB1-mutant cells. By investigating transcriptomes and genome occupancies in RB iPSC–derived osteoblasts (OBs), we discover that both E2F3a, which mediates spliceosomal gene expression, and pRB, which antagonizes E2F3a, coregulate more than one-third of spliceosomal genes by cobinding to their promoters or enhancers. Pharmacological inhibition of the spliceosome in RB1-mutant cells leads to global intron retention, decreased cell …

Ror Activation By Nobiletin Enhances Antitumor Efficacy Via Suppression Of Iκb/Nf-Κb Signaling In Triple-Negative Breast Cancer, Eunju Kim, Yoon-Jin Kim, Zhiwei Ji, Jin Muk Kang, Marvin Wirianto, Keshav Raj Paudel, Joshua A Smith, Kaori Ono, Jin-Ah Kim, Kristin Eckel-Mahan, Xiaobo Zhou, Hyun Kyoung Lee, Ji Young Yoo, Seung-Hee Yoo, Zheng Chen

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) is a heterogeneous disease characterized by poor response to standard therapies and therefore unfavorable clinical outcomes. Better understanding of TNBC and new therapeutic strategies are urgently needed. ROR nuclear receptors are multifunctional transcription factors with important roles in circadian pathways and other processes including immunity and tumorigenesis. Nobiletin (NOB) is a natural compound known to display anticancer effects, and our previous studies showed that NOB activates RORs to enhance circadian rhythms and promote physiological fitness in mice. Here, we identified several TNBC cell lines being sensitive to NOB, by itself or in combination. Cell and xenograft …

The Mother Of Exiles Is Abandoning Her Children: The Systemic Failure To Protect Unaccompanied Minors Arriving At Our Borders, Rosa M. Peterson

The Scholar: St. Mary's Law Review on Race and Social Justice

Unaccompanied minors arrive at the United States border every day. Many brought by the hope of finding a life lived without fear, a luxury many United States citizens take for granted. Their truths become the barriers and shackles which keep them in detention centers and unaccompanied minor facilities throughout the United States; children find their very words wielded as weapons against them in immigration court. Words often spoken to therapists in perceived confidence, during counseling sessions. This practice is a systemic failure to protect unaccompanied minors arriving at our borders who are seeking protection and help. The United States …

Protecting A Woman’S Right To Abortion During A Public Health Crisis, San Juanita Gonzalez

The Scholar: St. Mary's Law Review on Race and Social Justice

As COVID-19 infected our nation, states were quick to issue executive orders restricting various aspects of daily life under the pretense of public safety. It was clear at the outset that certain civil liberties were going to be tested. Among them, the constitutional right to an abortion.

This comment explores Texas’ response to the COVID-19 pandemic and the limitations it imposed on abortion access. It will attempt to address the legitimacy of the “public health concerns” listed in executive orders issued throughout numerous states and will discuss the pertinent legal framework and judicial scrutiny to apply.

According to the Fifth …

Leptospirosis Presenting As Diffuse Alveolar Hemorrhage, Alejandra González, Paola Alvarez, Mariano Fielli, Analia Santos, Neil Gomez Querales, Elkin Rodriguez Arzuaga

The University of Louisville Journal of Respiratory Infections

Diffuse alveolar hemorrhage (DAH) syndrome has a mortality rate of 30 to 60%. A 15-year-old male patient presented with a seven-day abdominal pain, vomiting, non-dysenteric diarrhea, conjunctival injection, and fever. Chest radiography revealed bilateral interstitial infiltrates predominating in the lower left lobe. The patient’s condition worsened within hours, with the development of massive hemoptysis, acute respiratory distress syndrome (ARDS), arterial hypotension, and hematocrit decline requiring mechanical ventilation. A chest computed tomography (CT) showed ground-glass opacities with consolidation areas in lower lobes, diffuse tree-in-bud opacities, and centrilobular nodules. A bronchoscopy was conducted without endoluminal lesions and bronchoalveolar lavage (BAL) consistent with …

Covid-19 Newsletter (Vol. 115), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Examining Nurse Engagement In Antimicrobial Stewardship At Long-Term Care Facilities, Mosam S. Patel, Kathryn L. Dambrino, Olivia Bahemuka, David Phillippi

DNP Projects

Background: The World Health Organization stated that antimicrobial resistance is one of the top 10 threats to global health. To combat antimicrobial resistance, antimicrobial stewardship (AMS) programs were developed. Efforts to engage nurses in stewardship efforts have been limited. Bedside nurses are in an optimal position to help decrease antimicrobial use, which is especially relevant in long-term care facilities where up to 75% of antibiotic use is deemed unnecessary or inappropriate. The purpose of this Doctor of Nursing Practice scholarly project was to examine factors that influence nurse engagement in AMS at long-term care facilities in Tennessee. Methods: A …