Medicine and Health Sciences Commons^™

Effect Of Provider Education On Urinary Incontinence Knowledge And Assessment, Kendra L. Roloff, Patricia Parker, Rhonda Schafer-Mclean, Robert West

Cooper Rowan Medical Journal

Nearly 50% of women in the United States will experience urinary incontinence at some point during their lives. Urinary incontinence impacts multiple aspects of a woman’s life, yet remains underdiagnosed by primary care providers. The Women’s Preventative Service Initiative released a recommendation in 2018 to screen all women annually for urinary incontinence. The recommendation was in response to the lack of women who seek care for urinary incontinence.

The purpose of this project was to implement education and reminders for primary care providers, in order to improve urinary incontinence knowledge and assessment of women 18 years of age or older. …

Mental Health And The Effects Of Stress And Violence On Migrant Farmworker Communities During The Covid-19 Pandemic, Russell Rice Manzano

USF Tampa Graduate Theses and Dissertations

Immigrants encounter numerous vulnerabilities during the migration process and after arrival due to stressors and violence that they may experience. Many also face dangerous labor conditions, discrimination, violence, and aggressive immigration tactics in the United States. The prolonged exposure to these stressors can create suffering for these vulnerable populations, continuing to exacerbate existing inequalities.

Since the beginning of the COVID-19 pandemic in 2020, immigrants have also faced new challenges that often perpetuate inequities that already existed in society. Immigrants often suffer from inadequate access to healthcare, marginalization due to legal status, and fear, which was worsened during the height of …

Medical Student Program To Learn From Families Experiencing Developmental Disabilities, Brigid Jacob, Ragda Izar, Hanna Tran, Katherine Akers, Anil N. F Aranha, Omar Afify, Elizabeth Janks, Jennifer Mendez

Internal Medicine Faculty Publications

Patients and families experiencing developmental disabilities (DDs) may lack trust in physicians due to negative experiences in healthcare. DDs include conditions impairing physical, learning, language, or behavior areas, beginning during the developmental period and impacting daily functioning ('Developmental Disabilities'). Medical students generally do not receive standard training to effectively communicate with and diagnose patients with DDs. ARIE is a program for medical students to meet and learn from these patients and their families. Students learn about these families’ experiences during home visits, guided by standardized interview questions and surveys about families’ trust in physicians. Families did not appear to strongly …

Trigeminal Herpes Zoster Transited To Ipsilateral Occipital Neuralgia, Keita Takizawa, Zhimin Yan, Jumi Nakata, Andrew Young, Junad Khan, Mythili Kalladka, Noboru Noma

Pacific Faculty Work

The pain of occipital neuralgia (ON) is thought to be secondary to trauma or injury to the occipital nerve at any point along the course of the nerve. ON may also be caused by an infectious process (herpes zoster) or compression of the nerve. The patient, in this case, presented to our clinic with complaints of occipital pain and rash and swelling of the right lower jaw. One week before presenting to our clinic, the patient developed severe pain in the first division of the trigeminal region with erythema and vesicles. A blood test showed a remarkably high antibody titer …

Empowering And Equipping Students To Nurture Their Personal Devotional Time., Ronda Christman, Beth Scott, Gary Bradley, Dionne Felix, Andrew Richards

Achieve

No abstract provided.

Aspnr Programing: Interesting Pediatric Neuroradiology Case Session (Sa-Cme): Seizures., A Krishnan

Conference Presentation Abstracts

No abstract provided.

One-Pot, One-Step Synthesis Of Drug-Loaded Magnetic Multimicelle Aggregates, Chang Soo Kim, Dmitry Nevozhay, Rebeca Romero Aburto, Ashok Pehere, Lan Pang, Rebecca Dillard, Ziqiu Wang, Clayton Smith, Kelsey Boitnott Mathieu, Marie Zhang, John D Hazle, Robert C Bast, Konstantin Sokolov

Faculty, Staff and Student Publications

Lipid-based formulations provide a nanotechnology platform that is widely used in a variety of biomedical applications because it has several advantageous properties including biocompatibility, reduced toxicity, relative ease of surface modifications, and the possibility for efficient loading of drugs, biologics, and nanoparticles. A combination of lipid-based formulations with magnetic nanoparticles such as iron oxide was shown to be highly advantageous in a growing number of applications including magnet-mediated drug delivery and image-guided therapy. Currently, lipid-based formulations are prepared by multistep protocols. Simplification of the current multistep procedures can lead to a number of important technological advantages including significantly decreased processing …

A Sailor’S Disease Presenting In Urban America With Red Spots On The Legs, John A. Buchan, Bruce H. Gray

Cooper Rowan Medical Journal

Sailors were often affected by nutritional deficiencies due to the absence of fresh foods on long voyages. One example is the development of scurvy from a lack of vitamin C ingestion. In modern society in which fresh food are available this disease is infrequently recognized. The following case describes a 62-year-old male who presented with “red spots” on his legs and a large area of ecchymosis on his thigh. After initial testing failed to elicit a cause, a dietary history revealed that the patient had a peculiar diet of only ice cream with a total avoidance of fruits and vegetables. …

Chronotype, Shift Work, And Sleep Problems Among Emergency Medicine Clinicians, Emily L. Hirsh, Thomas W. Britt, Zachary Klinefelter, Justine Liptak, Cody Meyers, Katie Daniels, Lauren A. Fowler

Journal of Wellness

Introduction: Extensive research has demonstrated that shift work can be detrimental to sleep. Chronotype, the preference for time of day to sleep or be active, can influence how we function at different times of day and how shift work impacts us. This study was designed to assess the chronotype of emergency physicians (EPs) and emergency advanced practice providers (EAPPs) and examine how chronotype was related to sleep problems and shifts worked over a three-month period.

Methods: A survey assessing chronotype and sleep quality was sent to 225 EPs and EAPPs in a single, large academic Department of Emergency Medicine. An …

Networks Of Necessity: Simulating Covid-19 Mitigation Strategies For Disabled People And Their Caregivers, Thomas E. Valles, Hannah Shoenhard, Joseph Zinski, Sarah Trick, Mason A. Porter, Michael R. Lindstrom

School of Mathematical & Statistical Sciences Faculty Publications

Abstract

A major strategy to prevent the spread of COVID-19 is the limiting of in-person contacts. However, limiting contacts is impractical or impossible for the many disabled people who do not live in care facilities but still require caregivers to assist them with activities of daily living. We seek to determine which interventions can best prevent infections of disabled people and their caregivers. To accomplish this, we simulate COVID-19 transmission with a compartmental model that includes susceptible, exposed, asymptomatic, symptomatically ill, hospitalized, and removed/recovered individuals. The networks on which we simulate disease spread incorporate heterogeneity in the risk levels of …

A Weakened Recurrent Circuit In The Hippocampus Of Rett Syndrome Mice Disrupts Long-Term Memory Representations, Lingjie He, Matthew S Caudill, Junzhan Jing, Wei Wang, Yaling Sun, Jianrong Tang, Xiaolong Jiang, Huda Y Zoghbi

Duncan NRI Faculty and Staff Publications

Successful recall of a contextual memory requires reactivating ensembles of hippocampal cells that were allocated during memory formation. Altering the ratio of excitation-to-inhibition (E/I) during memory retrieval can bias cell participation in an ensemble and hinder memory recall. In the case of Rett syndrome (RTT), a neurological disorder with severe learning and memory deficits, the E/I balance is altered, but the source of this imbalance is unknown. Using in vivo imaging during an associative memory task, we show that during long-term memory retrieval, RTT CA1 cells poorly distinguish mnemonic context and form larger ensembles than wild-type mouse cells. Simultaneous multiple …

The Emotional Impact Of Urinary Tract Infections In Women: A Qualitative Analysis, Larissa Grigoryan, Aruni Mulgirigama, Marcy Powell, Guido Schmiemann

Faculty, Staff and Students Publications

BACKGROUND: While many studies address the clinical management of participants with uncomplicated urinary tract infection (uUTI), the emotional impact of uUTIs has been investigated less often. The aim of this qualitative study was to understand the emotional experience of women with uUTIs.

METHODS: This was a qualitative, exploratory, in-depth interview-based study conducted among women in the United States (US) and Germany. Women aged ≥ 18 years with at least one uUTI treated with antibiotics in the past year were recruited through a patient community panel and physician referrals. Participants were recruited using purposive sampling to include an equal split of …

Exploring Glycolysis-Mediated Metabolic Stress And Mitigation Strategies In The Cns Through Glycation-Lowering Therapy, Cavan Patterson

Natural Sciences and Mathematics | Biological Sciences Master's Theses

In the aging brain, cells undergo stress, inflammation, loss of replicative ability and in some cases cell death. Hyperglycemic conditions have been shown to exacerbate these effects. Recent literature has begun to regard Alzheimer’s Disease as a “Type 3 Diabetes Mellitus,” implicating loss of insulin sensitivity and increased oxidative stress as contributing factors. Hyperglycemic conditions can overwhelm the cellular capacity to detoxify harmful glycolytic byproducts such as methylglyoxal (MGO). Intact MGO reacts readily with nearby proteins or lipids to form Advanced Glycation End products (AGEs), of which the accumulation over time has been linked to many age-associated pathologies. Our lab …

Small Molecule Compound With Indole Moiety Protects Against Alzheimer’S Disease Pathology In C. Elegans And Mammalian Cell Culture Models, Elena Battistoni

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Alzheimer's disease (AD) is a progressive neurodegenerative disease and the leading cause of dementia in the elderly. In 2020, an estimated 5.8 million Americans 65 and older were living with Alzheimer's dementia¹. Currently, the disease has no cure, and extensive research continues to explore potential treatments. Because the pathogenesis of AD has been attributed, at least in part, to the extracellular aggregation and toxicity of the amyloid beta (Aβ) protein in the brain, discovering therapeutics that target this protein remains of interest. However, many past drug development programs and clinical trials that target Aβ aggregates have been unsuccessful. …

Exploring The Diet Dependent Role Of Oxidation Resistance 1 In Regulating Retromer Function, Enrique Carrera

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Aging has been identified as a significant risk factor to the development of several diseases, such as neurodegeneration¹. One of the most common age-related neurodegenerative diseases is Alzheimer’s Disease (AD)², which causes cognitive decline. Current treatments for AD attempt to mitigate its symptoms or delay its onset^3–5. One method that has shown promise not only for the treatment of AD, but also for increasing lifespan and healthspan overall is dietary restriction (DR)⁶, but the mechanisms by which DR mediates these effects remains unclear^7,8. We have identified the human gene Oxidation …

Will Reducing Drug Prices Slow Innovation?, Gregory Vaughan, Fred Ledley

Mathematical Sciences Faculty Publications

The pharmaceutical industry has long argued that high drug prices reflect the high cost of innovation and that reducing drug prices would necessarily slow the pipeline of new drugs. These arguments have been bolstered by studies of large pharmaceutical companies showing statistical associations between the projected market size or revenue for pharmaceutical products and research & development (R&D) activity. Our analysis recognizes the increasingly important role of small biopharmaceuticals in drug development , companies that typically have little revenue and negative earnings, but are now responsible for more than 40% of new drug approvals. We examine the relationship between changes …

2022-05-17_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/data-about-places/long-term-care-data.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …

Deep Learning Modeling M6a Deposition Reveals The Importance Of Downstream Cis-Element Sequences., Zhiyuan Luo, Jiacheng Zhang, Jingyi Fei, Shengdong Ke

Faculty Research 2022

The N⁶-methyladenosine (m⁶A) modification is deposited to nascent transcripts on chromatin, but its site-specificity mechanism is mostly unknown. Here we model the m⁶A deposition to pre-mRNA by iM6A (intelligent m⁶A), a deep learning method, demonstrating that the site-specific m⁶A methylation is primarily determined by the flanking nucleotide sequences. iM6A accurately models the m⁶A deposition (AUROC = 0.99) and uncovers surprisingly that the cis-elements regulating the m⁶A deposition preferentially reside within the 50 nt downstream of the m⁶A sites. The m⁶A enhancers mostly …

Transcriptional Profiling Of Macrophages In Situ In Metastatic Melanoma Reveals Localization-Dependent Phenotypes And Function., Jan Martinek, Jianan Lin, Kyung In Kim, Victor G Wang, Te-Chia Wu, Michael Chiorazzi, Hannah Boruchov, Ananya Gulati, Shamreethaa Seeniraj, Lili Sun, Florentina Marches, Paul Robson, Anthony Rongvaux, Richard A Flavell, Joshy George, Jeffrey Chuang, Jacques Banchereau, Karolina Palucka

Faculty Research 2022

Modulation of immune function at the tumor site could improve patient outcomes. Here, we analyze patient samples of metastatic melanoma, a tumor responsive to T cell-based therapies, and find that tumor-infiltrating T cells are primarily juxtaposed to CD14⁺ monocytes/macrophages rather than melanoma cells. Using immunofluorescence-guided laser capture microdissection, we analyze transcriptomes of CD3⁺ T cells, CD14 ⁺ monocytes/macrophages, and melanoma cells in non-dissociated tissue. Stromal CD14⁺ cells display a specific transcriptional signature distinct from CD14⁺ cells within tumor nests. This signature contains LY75, a gene linked with antigen capture and regulation of tolerance and immunity in …

2022 May 17 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Highly Efficient Loading Program For En Route (Helper) App, Melissa A. Wilson, Kaya N. Brown, Brittany L. Fouts

Nursing Faculty Publications

Various embodiments of the disclosed subject matter provide systems, methods, architectures, mechanisms, apparatus and/or computer implemented method configured for automatically managing En Route Care (ERC) transport patient and medical equipment loading

Covid-19 Newsletter (Vol. 119), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Will Reducing Drug Prices Slow Innovation?, Gregory Vaughan, Fred Ledley

Natural & Applied Sciences Faculty Publications

The pharmaceutical industry has long argued that high drug prices reflect the high cost of innovation and that reducing drug prices would necessarily slow the pipeline of new drugs. These arguments have been bolstered by studies of large pharmaceutical companies showing statistical associations between the projected market size or revenue for pharmaceutical products and research & development (R&D) activity. Our analysis recognizes the increasingly important role of small biopharmaceuticals in drug development , companies that typically have little revenue and negative earnings, but are now responsible for more than 40% of new drug approvals. We examine the relationship between changes …

Cerium Dioxide, A Jekyll And Hyde Nanomaterial, Can Increase Basal And Decrease Elevated Inflammation And Oxidative Stress, Robert Yokel, Marsha L. Ensor, Hemendra J. Vekaria, Patrick G. Sullivan, David J. Feola, Arnold Stromberg, Michael T. Tseng, Douglas A. Harrison

Pharmaceutical Sciences Faculty Publications

It was hypothesized that the catalyst nanoceria can increase oxidative

stress/inflammation from the basal state and reduce it from the elevated state .

Nanoceria are cleared by macrophages. To test the hypothesis, M0 (non-polarized),

M1- (classically activated, pro-inflammatory), and M2-like (alternatively activated,

regulatory phenotype) RAW 264.7 macrophages were nanoceria exposed. Responses

were quantified by arginase activity, IL-1ß level, cell oxygen consumption rate (OCR),

the glycolysis stress test (GST), morphology determined by light microscopy,

macrophage phenotype marker expression and morphology using a novel three

dimensional immunohistochemical method, and RT-qPCR. Nanoceria blocked

arginase and IL-1ß effects, increased M0 cell OCR and GST …

Implementation Of A Primary Care Toolkit To Improve Dementia Diagnosis And Management In A Rural Setting, Meredith George-Wieland

Doctor of Nursing Practice Scholarly Projects

BACKGROUND: There are six million people with dementia living in the United States and this number is expected to rise exponentially due to the aging population. In the United States, it is estimated that only two thirds of dementia cases are recorded during primary care visits and an estimated, one third of cases have been either missed or disregarded.

LOCAL PROBLEM: In a remote primary care clinic on Kodiak Island, off the southeastern coast of Alaska, there is a lack of dementia and related cognitive diagnoses in the primary care setting due to patients’ and families lack access to the …

Fmrp Regulates Gabaa Receptor Channel Activity To Control Signal Integration In Hippocampal Granule Cells, Pan-Yue Deng, Ajeet Kumar, Valeria Cavalli, Vitaly A Klyachko

2020-Current year OA Pubs

Fragile X syndrome, the most common inherited form of intellectual disability, is caused by loss of fragile X mental retardation protein (FMRP). GABAergic system dysfunction is one of the hallmarks of FXS, yet the underlying mechanisms remain poorly understood. Here, we report that FMRP interacts with GABA

A Competence-Based Online Learning Video And In-Situ Simulation To Improve Perioperative Anesthesia Nurse Practitioner Self-Efficacy In Responding To Anesthesia Emergencies, Sara Durgerian

Doctor of Nursing Practice Scholarly Projects

Background: Nurse Practitioners (NPs) are broadly educated to the population-based role in which they practice. Further education in subspecialties is essential as more NPs are working autonomously in highly specialized care areas.

Problem: In the Department of Anesthesia at a large urban hospital, perioperative anesthesia NPs lack formal training in the subspecialty of anesthesia, which contributed to a lack of self-efficacy when responding to anesthesia emergencies.

Methods: An asynchronous multimodal brief instructional video accompanied by an in-situ simulation of an anesthesia emergency was developed to increase knowledge and confidence in perioperative anesthesia nurse practitioner response to anesthesia emergencies.

Results: A …

Early Short Course Of Neuromuscular Blocking Agents In Patients With Covid-19 Ards: A Propensity Score Analysis., Gianluigi Li Bassi, Kristen Gibbons, Jacky Y Suen, Heidi J Dalton, Nicole White, Amanda Corley, Sally Shrapnel, Samuel Hinton, Simon Forsyth, John G Laffey, Eddy Fan, Jonathon P Fanning, Mauro Panigada, Robert Bartlett, Daniel Brodie, Aidan Burrell, Davide Chiumello, Alyaa Elhazmi, Mariano Esperatti, Giacomo Grasselli, Carol Hodgson, Shingo Ichiba, Carlos Luna, Eva Marwali, Laura Merson, Srinivas Murthy, Alistair Nichol, Mark Ogino, Paolo Pelosi, Antoni Torres, Pauline Yeung Ng, John F Fraser

Department of Anesthesiology Faculty Papers

BACKGROUND: The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate in COVID-19 patients with moderate-to-severe ARDS the impact of early use of NMBAs on 90-day mortality, through propensity score (PS) matching analysis.

METHODS: We analyzed a convenience sample of patients with COVID-19 and moderate-to-severe ARDS, admitted to 244 intensive care units within the COVID-19 Critical Care Consortium, from February 1, 2020, through October 31, 2021. Patients undergoing at least 2 days and up to 3 consecutive days of NMBAs (NMBA treatment), within 48 …

Increase In Postural Orthostatic Tachycardia Syndrome (Pots) After Covid-19 Infection, Nana Dufie Akowuah

Student Theses

A new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), popularly known as COVID-19 has been associated with new-onsets of neurological and cardiovascular symptoms after infecting people. Postural Orthostatic Tachycardia Syndrome (POTS), a form of dysautonomia, can occur after a viral or bacterial infection. Some symptoms of POTS include dizziness, postural tachycardia, presyncope and orthostatic intolerance. There has been some evidence that has identified POT following COVID-19 in some patients. Commonly affected are female long haulers of child-bearing age sharing a strikingly similar demographic to most autoimmune disorders. The most dominant symptom of long haul POTS at this point may be palpitations/ …

The Multidimensional Test Anxiety Scale: A Latent Profile Analysis And An Examination Of Measurement Invariance, Gabrielle Francis

USF Tampa Graduate Theses and Dissertations

Standardized testing is an integral part of the English and American education systems. The objectives of these tests are to evaluate students, teachers, and schools. However, this evaluation has unintended consequences, one of which is test anxiety. Over the last 50 years, there has been an increase in studies on test anxiety because of the widespread use of standardized tests (Hembree, 1988; von der Embse et al., 2019). However, two areas that have seen little attention are the measurement invariance of test anxiety scales across demographic groups, and the creation of classification standards for these test anxiety scales to increase …