Medicine and Health Sciences Commons^™

Poly(Gr) And Poly(Ga) In Cerebrospinal Fluid As Potential Biomarkers For C9orf72-Als/Ftd, Gopinath Krishnan, Timothy M Miller, Et Al

2020-Current year OA Pubs

GGGGCC repeat expansion in C9ORF72, which can be translated in both sense and antisense directions into five dipeptide repeat (DPR) proteins, including poly(GP), poly(GR), and poly(GA), is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we developed sensitive assays that can detect poly(GA) and poly(GR) in the cerebrospinal fluid (CSF) of patients with C9ORF72 mutations. CSF poly(GA) and poly(GR) levels did not correlate with age at disease onset, disease duration, or rate of decline of ALS Functional Rating Scale, and the average levels of these DPR proteins were similar in symptomatic and pre-symptomatic …

Human M1 Macrophages Express Unique Innate Immune Response Genes After Mycobacterial Infection To Defend Against Tuberculosis, Arshad Khan, Kangling Zhang, Vipul K. Singh, Abhishek Mishra, Priyanka Kachroo, Tian Bing, Jong Hak Won, Eder Ledezma-Campos, Genesis P. Aguillón-Durán, Blanca I. Restrepo

School of Medicine Publications

Mycobacterium tuberculosis (Mtb) is responsible for approximately 1.5 million deaths each year. Though 10% of patients develop tuberculosis (TB) after infection, 90% of these infections are latent. Further, mice are nearly uniformly susceptible to Mtb but their M1-polarized macrophages (M1-MΦs) can inhibit Mtb in vitro, suggesting that M1-MΦs may be able to regulate anti-TB immunity. We sought to determine whether human MΦ heterogeneity contributes to TB immunity. Here we show that IFN-γ-programmed M1-MΦs degrade Mtb through increased expression of innate immunity regulatory genes (Inregs). In contrast, IL-4-programmed M2-polarized MΦs (M2-MΦs) are permissive for Mtb proliferation and exhibit reduced …

Rapid Molecular Diagnostics Of Tuberculosis Resistance By Targeted Stool Sequencing, Doctor B Sibandze, Alexander Kay, Viola Dreyer, Welile Sikhondze, Qiniso Dlamini, Andrew Dinardo, Godwin Mtetwa, Bhekumusa Lukhele, Debrah Vambe, Christoph Lange, Muyalo Glenn Dlamini, Tara Ness, Rojelio Mejia, Barbara Kalsdorf, Jan Heyckendorf, Martin Kuhns, Florian P Maurer, Sindisiwe Dlamini, Gugu Maphalala, Stefan Niemann, Anna Mandalakas

Faculty, Staff and Students Publications

BACKGROUND: Stool is an important diagnostic specimen for tuberculosis in populations who struggle to provide sputum, such as children or people living with HIV. However, the culture of Mycobacterium tuberculosis (M. tuberculosis) complex strains from stool perform poorly. This limits the opportunity for phenotypic drug resistance testing with this specimen. Therefore, reliable molecular methods are urgently needed for comprehensive drug resistance testing on stool specimens.

METHODS: We evaluated the performance of targeted next-generation sequencing (tNGS, Deeplex® Myc-TB) for the detection of mutations associated with M. tuberculosis complex drug resistance on DNA isolated from stool specimens provided by participants from a …

Mathematical Model Of Zika Epidemic In Colombia, Sethupathy Ganesan

Biology and Medicine Through Mathematics Conference

No abstract provided.

Studying The Effect Of Western Diet On Atherosclerosis Risk Factors, Eric L. Scott, Rebecca Segal, Angela M. Reynolds

Biology and Medicine Through Mathematics Conference

No abstract provided.

Scale-Free Properties Influence Breathing Rhythmogenesis., Cameron Grover

Biology and Medicine Through Mathematics Conference

No abstract provided.

Cooccurrr - Applying Glcm Analysis Techniques To Non-Image Objects Such As Fitness Landscapes, Steph J. Owen

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling The Spread Of Sars-Cov-2 Inside The Human Respiratory Tract: A Parameter Sensitivity Study, Jason Pearson

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling Viral Resistance To Monotherapy With Monoclonal Antibody Treatment For Sars-Cov-2, Tin Phan, Carolin Zitzmann, Alan S. Perelson, Ruy M. Ribeiro, Ruian Ke

Biology and Medicine Through Mathematics Conference

No abstract provided.

Effect Of Myeloid-Derived Suppressor Cells On Glioblastoma-Immune Dynamics, Hannah Anderson

Biology and Medicine Through Mathematics Conference

No abstract provided.

Approximate Bayesian Computation For Generating 3d Structured Trees To Model The Pulmonary Arterial Network, Megan J. Chambers

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Spatially Dependent Model For Photoreceptors In A Healthy Eye, Danielle C. Brager, Anthony Kearsley, Daniel Anderson

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Modelling Of Oncolytic Virotherapy As A Cancer Treatment, Maila Hallare, Iordanka Panayotova

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Within-Host Modeling Framework For Sars-Cov-2 Infection To Support Vaccine Strategies, Morgan Rose, Rachel Jennings, Jeffry Schroeter

Biology and Medicine Through Mathematics Conference

No abstract provided.

Osmotic Perturbation Promotes Competition Between Bacteria In Gut, Shaikh Obaidullah

Biology and Medicine Through Mathematics Conference

No abstract provided.

Seasonality And The Dynamics Of Mycobacterium Ulcerans Transmission., Kwame E. Osei Bonsu

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Modeling Of Brain Cancer Growth Using A Level-Set Method, Gbocho M. Terasaki

Biology and Medicine Through Mathematics Conference

No abstract provided.

Sensitivity And Bifurcation Analysis Of Tuberculosis Progression, Wenjing Zhang

Biology and Medicine Through Mathematics Conference

No abstract provided.

Thoracoabdominal Asynchrony In A Virtual Preterm Infant: Computational Modeling And Analysis, Richard R. Foster, Laura Ellwein Fix

Biology and Medicine Through Mathematics Conference

No abstract provided.

Spatial Patterning Of Predator-Prey Distributions Arising From Prey Defense, Evan C. Haskell, Jonathan Bell

Biology and Medicine Through Mathematics Conference

No abstract provided.

An Ode Model For Predicting Pediatric Patient Pain In Scd Based On Patient Sleep Data, Quindel Jones, Rebecca Segal, Angela M. Reynolds, Cecelia Valrie, Reginald Mcgee

Biology and Medicine Through Mathematics Conference

No abstract provided.

A. Poster Session, 1. Poster

Biology and Medicine Through Mathematics Conference

No abstract provided.

Study Of Cardiovascular Dynamics During Graded Head-Up Tilt Test In The Young With Syncope Tendency, Martin A. Miranda Sr

Biology and Medicine Through Mathematics Conference

No abstract provided.

Intervention Time Series Analysis Of Organ Donor Transplants In The Us, Supraja Malladi

Biology and Medicine Through Mathematics Conference

No abstract provided.

Effects Of Local Mutations In Quadratic Iterations, Anca R. Radulescu, Abraham Longbotham

Biology and Medicine Through Mathematics Conference

No abstract provided.

Computational Model Of Mutant Arpp Protein Aggregation And Diffusion And Its Impact On Calcium Dynamics And Stress Responses Using Neuron., Gaby Clarke

Biology and Medicine Through Mathematics Conference

No abstract provided.

Multiclass Classification And Prevalence Estimation With Applications To Sars-Cov-2 Antibody Assays, Rayanne Luke, Paul N. Patrone, Anthony J. Kearsley

Biology and Medicine Through Mathematics Conference

No abstract provided.

Olfactory Bulb Processing Of Ortho Versus Retronasal Odors, Michelle F. Craft, Andrea Barreiro, Shree Gautam, Woodrow Shew, Cheng Ly

Biology and Medicine Through Mathematics Conference

No abstract provided.

Optimal Allocation Of Limited Testing Resources For Controlling Epidemic Outbreaks, Jeffery Demers, William F. Fagan, Justin M. Calabrese

Biology and Medicine Through Mathematics Conference

No abstract provided.

Analysis Of Tear-Film Breakup Using Fluorescence Video Recordings, Tobin Driscoll, Richard Braun, Rayanne Luke, Carolyn G. Begley

Biology and Medicine Through Mathematics Conference

No abstract provided.