Medicine and Health Sciences Commons^™

2022-05-25_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/stats.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted once a week on Wednesdays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) …

A Simple Standard For Sharing Ontological Mappings (Sssom)., Nicolas Matentzoglu, James P Balhoff, Susan M. Bello, Chris Bizon, Matthew Brush, Tiffany J Callahan, Christopher G Chute, William D Duncan, Chris T Evelo, Davera Gabriel, John Graybeal, Alasdair Gray, Benjamin M Gyori, Melissa Haendel, Henriette Harmse, Nomi L Harris, Ian Harrow, Harshad B Hegde, Amelia L Hoyt, Charles T Hoyt, Dazhi Jiao, Ernesto Jiménez-Ruiz, Simon Jupp, Hyeongsik Kim, Sebastian Koehler, Thomas Liener, Qinqin Long, James Malone, James A Mclaughlin, Julie A Mcmurry, Sierra Moxon, Monica C Munoz-Torres, David Osumi-Sutherland, James A Overton, Bjoern Peters, Tim Putman, Núria Queralt-Rosinach, Kent Shefchek, Harold Solbrig, Anne Thessen, Tania Tudorache, Nicole Vasilevsky, Alex H Wagner, Christopher J Mungall

Faculty Research 2022

Despite progress in the development of standards for describing and exchanging scientific information, the lack of easy-to-use standards for mapping between different representations of the same or similar objects in different databases poses a major impediment to data integration and interoperability. Mappings often lack the metadata needed to be correctly interpreted and applied. For example, are two terms equivalent or merely related? Are they narrow or broad matches? Or are they associated in some other way? Such relationships between the mapped terms are often not documented, which leads to incorrect assumptions and makes them hard to use in scenarios that …

Musmorph, A Database Of Standardized Mouse Morphology Data For Morphometric Meta-Analyses., Jay Devine, Marta Vidal-García, Wei Liu, Amanda Neves, Lucas D Lo Vercio, Rebecca M Green, Heather A Richbourg, Marta Marchini, Colton M Unger, Audrey C Nickle, Bethany Radford, Nathan M Young, Paula N Gonzalez, Robert E Schuler, Alejandro Bugacov, Campbell Rolian, Christopher J Percival, Trevor Williams, Lee Niswander, Anne L Calof, Arthur D Lander, Axel Visel, Frank R Jirik, James M Cheverud, Ophir D Klein, Ramon Y Birnbaum, Amy E Merrill, Rebecca R Ackermann, Daniel Graf, Myriam Hemberger, Wendy Dean, Nils D Forkert, Stephen A Murray, Henrik Westerberg, Ralph S Marcucio, Benedikt Hallgrímsson

Faculty Research 2022

Complex morphological traits are the product of many genes with transient or lasting developmental effects that interact in anatomical context. Mouse models are a key resource for disentangling such effects, because they offer myriad tools for manipulating the genome in a controlled environment. Unfortunately, phenotypic data are often obtained using laboratory-specific protocols, resulting in self-contained datasets that are difficult to relate to one another for larger scale analyses. To enable meta-analyses of morphological variation, particularly in the craniofacial complex and brain, we created MusMorph, a database of standardized mouse morphology data spanning numerous genotypes and developmental stages, including E10.5, E11.5, …

Full Issue, The Stimulus Team

Stimulus: A Medical Humanities Journal

No abstract provided.

2022-05-25_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus/stats/coronavirus-symptoms. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated twice a week on Mondays and Thursdays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, …

Out-Of-Hospital Births And The Experiences Of Emergency Ambulance Clinicians And Birthing Parents: A Scoping Review Protocol, Michella Hill, Alecka Miles, Belinda Flanagan, Brennen Mills, Luke Hopper

Research outputs 2022 to 2026

Introduction Emergency ambulance clinicians attend a wide range of prehospital emergencies, including out-of-hospital births (OOHBs). Intrapartum care comprises approximately 0.05% of emergency medical services' caseload, with only ∼ 10% of intrapartum cases progressing to birth in emergency ambulance clinician care. However, this low exposure rate potentially allows obstetric clinical skills and knowledge to decay, which may impact on patient care. Additionally, unplanned OOHBs are known to have a higher incidence of complications and adverse outcomes than their counterparts born in hospital, such as postpartum haemorrhage or hypothermia. This scoping review will explore OOHBs and associated complications in emergency ambulance clinician …

Maf1, A Repressor Of Rna Polymerase Iii-Dependent Transcription, Regulates Bone Mass, Ellen Phillips, Naseer Ahmad, Li Sun, James Iben, Christopher J Walkey, Aleksandra Rusin, Tony Yuen, Clifford J Rosen, Ian M Willis, Mone Zaidi, Deborah L Johnson

Faculty, Staff and Students Publications

MAF1, a key repressor of RNA polymerase (pol) III-mediated transcription, has been shown to promote mesoderm formation in vitro. Here, we show that MAF1 plays a critical role in regulating osteoblast differentiation and bone mass. Global deletion of MAF1 (Maf1-/- mice) produced a high bone mass phenotype. However, osteoblasts isolated from Maf1-/- mice showed reduced osteoblastogenesis ex vivo. Therefore, we determined the phenotype of mice overexpressing MAF1 in cells from the mesenchymal lineage (Prx1-Cre;LSL-MAF1 mice). These mice showed increased bone mass. Ex vivo, cells from these mice showed enhanced osteoblastogenesis concordant with their high …

A Concise Synthetic Method For Constructing 3-Substituted Piperazine-2-Acetic Acid Esters From 1,2-Diamines, Srinivas Chamakuri, Sunny Ann Tang, Kevin A Tran, Shiva Krishna Reddy Guduru, Peter K Bolin, Kevin R Mackenzie, Damian W Young

Faculty, Staff and Students Publications

We report a short synthetic route for synthesizing 2,3-substituted piperazine acetic acid esters. Optically pure amino acids were efficiently converted into 1,2-diamines that could be utilized to deliver the title 2,3-substituted piperazines in five steps with a high enantiomeric purity. The novel route facilitated, for the first time, the synthesis of 3-phenyl substituted-2-piperazine acetic acid esters that were difficult to achieve using other methods; however, in this case, the products underwent racemization.

Letter From Dr. Gellman, Steven Gellman

Stimulus: A Medical Humanities Journal

No abstract provided.

Five Stages Of Grief: After You’Re Gone, Karyssa Nelson

Stimulus: A Medical Humanities Journal

No abstract provided.

Letter From The Dean Of The College Of Liberal Arts, Dan Cavanagh

Stimulus: A Medical Humanities Journal

No abstract provided.

The Day I Decided To Chase The Sun, Dana Johnson

Stimulus: A Medical Humanities Journal

No abstract provided.

Shoreline Spirituality, Steven Gellman

Stimulus: A Medical Humanities Journal

No abstract provided.

Fatphobia In Healthcare: A Fat Studies Perspective And Reading List, Sarah A. Shelton

Stimulus: A Medical Humanities Journal

No abstract provided.

Health Promotion By Using Collaborative Educational Games For The Women Of Angeline’S, Sinclair Ralston, Carmen Connolly, Alexsis Azcueta, Theresa Domingo, Natalie Gray, Ashley Reola

Nursing Leadership in Community Engagement Projects

Introduction

Founded in 1894, the Seattle Young Women’s Christian Association (YWCA) was developed to support and empower women of all ages, races, and backgrounds. Since then, the Seattle YWCA has grown and focused its efforts on addressing racial and socioeconomic disparities, especially inequities found within the female homeless population (Andrews, 2004). Angeline’s Day Center is a program offered by YWCA and is located in downtown Seattle. It serves approximately 200 women a day by providing overnight shelter, breakfast and lunch services, healthcare access, and amenities like showers, bathrooms, and laundry (“Angeline’s Day Center”, 2022). After completing a windshield survey and …

Sex-Specific Mitochondrial Dynamics And Mitophagy Response To Muscle Damage, Hui Ying Luk, Nigel C. Jiwan, Casey R. Appell, Danielle E. Levitt, Jakob L. Vingren

School of Medicine Faculty Publications

Muscle damage imposes stress on mitochondria resulting in mitochondrial fusion, fission, and mitophagy. Testosterone is a regulator of these processes. However, no study has examined the effect of sex-specific resistance exercise (RE)-induced hormonal response on mitochondrial dynamics and mitophagy after muscle damage in untrained men and women. Untrained men and women performed two sessions of 80 unilateral maximal eccentric knee extensions (ECC) followed by upper-body RE (ECC+RE) aimed to induce hormonal changes and maintain a similar lower body demands between conditions or 20 min seated rest (ECC+REST). Vastus lateralis samples were analyzed for gene and protein expression of OPA1, MFN1, …

Resistant Maltodextrin Consumption In A Double-Blind, Randomized, Crossover Clinical Trial Induces Specific Changes In Potentially Beneficial Gut Bacteria, Volker Mai, Alyssa M Burns, Rebecca J Solch, Jennifer C Dennis-Wall, Maria Ukhanova, Bobbi Langkamp-Henken

Faculty, Staff and Student Publications

Background: We have previously reported that the addition of resistant maltodextrin (RMD), a fermentable functional fiber, to the diet increases fecal weight as well as the amount of fecal bifidobacteria. Here, we report on the targeted analysis of changes in potentially beneficial gut bacteria associated with the intervention. Objective: The primary objective of this study was to determine the effect of adding 0, 15 and 25 g RMD to the diets of healthy free-living adults on potentially beneficial gut bacteria. Methods: We expanded on our previously reported microbiota analysis in a double-blind, placebo-controlled feeding study (NCT02733263) by performing additional qPCR …

Women's Health: Optimal Nutrition Throughout The Lifecycle, Edith J M Feskens, Regan Bailey, Zulfiqar Ahmed Bhutta, Hans-Konrad Biesalski, Heather Eicher-Miller, Klaus Krämer, Wen-Harn Pan, James C. Griffiths

Department of Paediatrics and Child Health

Sex differences are an important consideration when researching and establishing policies for nutrition and optimal health. For women's health, there are important physiologic, neurologic, and hormonal distinctions throughout the lifecycle that impact nutritional needs. Distinct from those for men, these nutritional needs must be translated into appropriate nutrition policy that aims to not only avoid overt nutritional deficiency, but also to promote health and minimize risk for chronic disease. Through a series of webinars, scientific experts discussed the advances in the understanding of the unique nutritional needs, challenges and opportunities of the various life stages for women across the life …

Cardiovascular Tropism And Sequelae Of Sars-Cov-2 Infection, Oleksandr Dmytrenko, Kory J Lavine

2020-Current year OA Pubs

The extrapulmonary manifestation of coronavirus disease-19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), became apparent early in the ongoing pandemic. It is now recognized that cells of the cardiovascular system are targets of SARS-CoV-2 infection and associated disease pathogenesis. While some details are emerging, much remains to be understood pertaining to the mechanistic basis by which SARS-CoV-2 contributes to acute and chronic manifestations of COVID-19. This knowledge has the potential to improve clinical management for the growing populations of patients impacted by COVID-19. Here, we review the epidemiology and pathophysiology of cardiovascular sequelae of COVID-19 and outline …

Comparative Studies Between The Murine Immortalized Brain Endothelial Cell Line (Bend.3) And Induced Pluripotent Stem Cell-Derived Human Brain Endothelial Cells For Paracellular Transport, Jiahong Sun, Weijun Ou, Derick Han, Annlia Paganini-Hill, Mark J. Fisher, Rachita K. Sumbria

Pharmacy Faculty Articles and Research

Brain microvascular endothelial cells, forming the anatomical site of the blood-brain barrier (BBB), are widely used as in vitro complements to in vivo BBB studies. Among the immortalized cells used as in vitro BBB models, the murine-derived bEnd.3 cells offer culturing consistency and low cost and are well characterized for functional and transport assays, but result in low transendothelial electrical resistance (TEER). Human-induced pluripotent stem cells differentiated into brain microvascular endothelial cells (ihBMECs) have superior barrier properties, but the process of differentiation is time-consuming and can result in mixed endothelial-epithelial gene expression. Here we performed a side-by-side comparison of the …

Understanding The Relationship Between Illness Perceptions Of Breast Cancer And Perceived Risk In A Sample Of U.A.E. Female University Students: The Role Of Comparative Risk, Maria J. Figueiras, David Dias Neto, João Marôco

All Works

BackgroundIn the Middle East region, the incidence of breast cancer (BC) has substantially increased in the last years. Despite a considerable body of research about BC in Arab countries, how illness perceptions of healthy women about BC may influence risk perception is unknown.MethodsA cross-sectional survey was conducted on a sample of 298 young Emirati women. The measures included demographic information, illness perceptions, and risk perception. Descriptive and correlational analyses were performed to assess illness perceptions about BC, perceived individual risk and comparative risk. A structural equation modelling (S.E.M.) was built to investigate the relationship between illness perceptions and perceived individual …

The Operation Successful, But The Patient Died. The Gradual Elimination Of The Central European Peasantry In The Light Of Globalization And Interwar Processes, Janos Fritz

Journal of Global Awareness

In terms of “depeasantisation," it was with the EU accession in 2004 when Central Europe – including Hungary – reached the stage where England had already arrived in the 18th and Germany in the 19th century. The gradual disappearance of the peasantry in the continent is doubtless in connection with the tendencies of globalization, a phenomenon that could not be stopped even by the authoritarian regimes of the interwar period – the time period examined by the dissertation. However, in a latent way, the question had already arisen at the time: is peasantry necessary at all? Nevertheless, as a consequence …

Raytheon Technologies Corporation: An Analysis Of Leadership, Ethics, And Social Responsibility, Jarett Monterio

Journal of Global Awareness

The purpose of this analysis is to examine Raytheon Technologies Corporation (RTC) in the context of its leadership structure, ethical issues and practices, stakeholder relationships, and position within the social responsibility realm. Undertaking an analysis of an aerospace and defense company such as RTC is perhaps timelier than ever. We live in a world of increasing global competition and confrontation. Simultaneously, we are experiencing unprecedented technological development. Combined, this has created a situation where the boundaries of conventional warfare have been redrawn. The questions of what appropriate offensive and defensive tactics are and how governments, and increasingly private sector companies, …

Mentoring Students Of Disadvantaged Background In Hungary — “Let’S Teach For Hungary!” As An Equitable Intervention In The Public School System, Gergely Horváth

Journal of Global Awareness

The introductory study aims to give an insight into the Hungarian educational system and a mentor program aiming to facilitate development in social mobility in the country. In the Hungarian context of education, the concept of equality and equity is a current phenomenon that influences students of underprivileged families. In Hungary, among students living in the countryside, the intersectionality of disadvantages is observed. Several regions of the country have features of unemployment and low education. Thus, students from underprivileged families face a deficit of capital when entering and proceeding into the educational system. The situation is further complicated for the …

Determinants Of Cognitive Health Among Aging Adults In Agincourt, South Africa, Bria Brown

Journal of Global Awareness

This study examines influences on cognitive health, showing how aging increases the odds of cognitive impairment by focusing on orientation to time and person among aging adults in Agincourt, South Africa. The Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in SA (HAALSI) Cohort from the Agincourt data set was used. Binary logistic regression analysis examined factors associated with cognition. Ability to read and/or write positively correlated with the correct recall of year, month, and date. Marital status, HIV status, and hypertension negatively correlated with the correct recall of year, month, and date. Correct recall of …

Local Garage Psychosis Rockabilly Disease: Glocalization And The Athenian Psychobilly, Michael Tsangaris

Journal of Global Awareness

Music is an art that permeates every human society. It is used for such diverse social purposes as ritual, worship, coordination of movement, communication, or entertainment. There are no limits to music as it can move freely in space through sound waves, radio, cinema, television, and the new digital technologies. Music is directly related to subcultures in that cultural identities and lifestyles can be mediated through music. This article aims to use the development of music scenes such as psychobilly to establish a link between music, subcultures, globalization, and the global-local dialectic.

Contextualizing The Impact Of Faculty-Led Short-Term Study Abroad On Students’ Global Competence: Characteristics Of Effective Programs, Colleen Fisher, Laurel Iverson Hitchcock, Ashley Neyer, Stacy C. Moak, Sarah Moore, Scott Marsalis

Journal of Global Awareness

Short-term faculty-led study abroad programs are high-impact pedagogical practices designed to enhance students' global competency. However, there is a gap in our understanding regarding the specific educational components of short-term faculty-led study abroad programs that promote global competency. This systematic review examined nearly two decades of research on such programs (n=86) to assess the educational components associated with increases in students' global competencies using Steinberg's (2017) educational components as a framework. Results indicated that the educational components included in global competency-building education abroad courses varied substantially across programs and global regions. The components most strongly supporting enhanced global competency were …

Notes From The Editor, Jay Nathan

Journal of Global Awareness

No abstract provided.

Medical School Watercooler Newsletter - May 24, 2022, Lindsey Lyle

Watercooler Newsletter

This is the May 24, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• M3 Case Symposium set for Friday
• Herrera presents on renal disease at international conference
• USA College of Medicine offers medical and science editing and writing service
• Kestler and Tyler highlight need for better TB diagnostic tools

2022-05-24_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/data-about-places/long-term-care-data.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …