Medicine and Health Sciences Commons^™

Proteolysis-Targeting Chimera (Protac) For Targeted Protein Degradation And Cancer Therapy, Xin Li, Yongcheng Song

Faculty, Staff and Students Publications

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. A bifunctional PROTAC molecule consists of a ligand (mostly small-molecule inhibitor) of the protein of interest (POI) and a covalently linked ligand of an E3 ubiquitin ligase (E3). Upon binding to the POI, the PROTAC can recruit E3 for POI ubiquitination, which is subjected to proteasome-mediated degradation. PROTAC complements nucleic acid-based gene knockdown/out technologies for targeted protein reduction and could mimic pharmacological protein inhibition. To date, PROTACs targeting ~ 50 proteins, many of which are clinically validated drug targets, have been successfully developed with several …

Hypogeusia As The Initial Presenting Symptom Of Covid-19, Lauren E Melley, Eli Bress, Erik Polan

PCOM Scholarly Works

COVID-19 is the disease caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first arose in Wuhan, China, in December 2019 and has since been declared a pandemic. The clinical sequelae vary from mild, self-limiting upper respiratory infection symptoms to severe respiratory distress, acute cardiopulmonary arrest and death. Otolaryngologists around the globe have reported a significant number of mild or otherwise asymptomatic patients with COVID-19 presenting with olfactory dysfunction. We present a case of COVID-19 resulting in intensive care unit (ICU) admission, presenting with the initial symptom of disrupted taste and flavour perception prior to respiratory …

Transcriptional Analyses Of Adult And Pediatric Adamantinomatous Craniopharyngioma Reveals Similar Expression Signatures Regarding Potential Therapeutic Targets., Eric Prince, Ros Whelan, Andrew Donson, Susan Staulcup, Astrid Hengartner, Trinka Vijmasi, Chibueze Agwu, Kevin O Lillehei, Nicholas K Foreman, James M Johnston, Luca Massimi, Richard C E Anderson, Mark M Souweidane, Robert P Naftel, David D Limbrick, Gerald Grant, Toba N Niazi, Roy Dudley, Lindsay Kilburn, Eric M Jackson, George I Jallo, Kevin Ginn, Amy Smith, Joshua J Chern, Amy Lee, Annie Drapeau, Mark D Krieger, Michael H Handler, Todd C Hankinson, Advancing Treatment For Pediatric Craniopharyngioma Consortium

Manuscripts, Articles, Book Chapters and Other Papers

Adamantinomatous craniopharyngioma (ACP) is a biologically benign but clinically aggressive lesion that has a significant impact on quality of life. The incidence of the disease has a bimodal distribution, with peaks occurring in children and older adults. Our group previously published the results of a transcriptome analysis of pediatric ACPs that identified several genes that were consistently overexpressed relative to other pediatric brain tumors and normal tissue. We now present the results of a transcriptome analysis comparing pediatric to adult ACP to identify biological differences between these groups that may provide novel therapeutic insights or support the assertion that potential …

The History Of The Dental Profession - From Ancient Origins To Modern Day, Steven A. Kezian

Pacific Journal of Health

Abstract:

This research paper explores some of the earliest known evidences of dental treatment and traveled through time discussing important figures who made vital contributions toward the development of this profession.

Dentistry is one of the oldest professions to be developed. Ever since there have been humans, there have been problems with our teeth, and we have been figuring out ways to alleviate them. The idea that there were people specializing in the healing of the teeth and oral diseases has roots to ancient pre-history and a long and fascinating saga.

This history is divided into five stages:

-Ancient pre-history …

Commentary: Phytocannabinoids As Therapeutic Agents To Combat Chronic Gingival Disease., Nick Narek Ohanian

Pacific Journal of Health

The therapeutic potential of cannabis has been harnessed for thousands of years yet the United States Food and Drug Administration (FDA) has still not approved cannabis as a safe or effective drug. The FDA has, however, approved the manufacturing of pharmaceutical drugs, which contain a “synthetic version of a substance that is present in the marijuana” and other compounds that mimic its action. A search of the US National Library of Medicine and National Institute of Health for keywords “CBD” and “Periodontitis” together yields only 2 publications. Although the current State and Federal regulations on the use of cannabis for …

Observation Status Stays May Result In Financial Losses For Children’S Hospitals, David C. Synhorst

Research Days

No abstract provided.

Pathways To Publication In Pediatric Hospital Medicine Educational Research, Joy L. Solano

Research Days

No abstract provided.

Increasing Frequency Of Discharge Communication Between Primary Care Physicians And Resident Teams After Hospital Admission For High Risk Patients: An Improvement Project In A Large Pediatric Hospital, Kelsey Clary, Lyndsey Hultman

Research Days

No abstract provided.

Effects Of Different Aerobic Training Techniques On Vital Capacity And Breath Hold, Luke Fickenworth, Jarrod Fair, Triet Le, Ashlynn Hickey

Aurora

Athletes are constantly looking for ways to increase their lung capacity. The larger the lung capacity, the more air, specifically oxygen, can be taken in by the athlete. Thus, increasing lung capacity increases endurance, allowing athletes to perform at a higher level for longer periods of time without feeling tired. If lung capacity remains the same while duration or intensity of activity increases, oxygen intake remains the same and there is more stress on the heart to get more oxygen to muscles and remove waste (Rathi 2014). This study will test breath hold time and vital capacity in order to …

Right Arm Pain, Color Change And Swelling In A 17-Year-Old Male Baseball Pitcher, Alvin Chi

Research Days

No abstract provided.

A Comparison Of Emoji Characters To Picture Optotypes, Simran Brar

Research Days

No abstract provided.

An Unusual Case Of Abdominal Pain In A 5-Year-Old With Biliary Atresia Splenic Malformation Syndrome, David Simon

Research Days

No abstract provided.

Effect Of Anemia On Neurocognitive Outcome In Children With Chronic Kidney Disease, Nisha S. Singh

Research Days

No abstract provided.

Optimization Of Pediatric Bowel Management Using An Antegrade Enema Troubleshooting Protocol, Obiyo O. Osuchukwu

Research Days

No abstract provided.

Post-Operative Intra-Abdominal Abscess After Appendectomy – Are Drains Necessary In All Patients?, Obiyo O. Osuchukwu

Research Days

No abstract provided.

Youth Athlete’S Hip Pops Him Out Of Soccer Game, Stephanie Tow

Research Days

No abstract provided.

Medical Student Understanding Of The Pm&R Specialty, Disability, And Post-Acute Care, Stephanie Tow

Research Days

No abstract provided.

Vaccine Mandates And The Tragedy Of The Commons, Ian D. Wolfe

Research Days

No abstract provided.

Pediatric Intensivists' Perspectives On Nudging, Aliza Olive

Research Days

No abstract provided.

When Improper Disposal Leads To More Than Hospital Visits: The Need For A National Standard For Used Medical Sharps, Albana Zherka

William & Mary Environmental Law and Policy Review

No abstract provided.

Volume 6 Full Text, Bjur Staff

Butler Journal of Undergraduate Research

No abstract provided.

Women’S Empowerment Or Exploitation Of Women? Examining The Implications Of Economic Empowerment Programming, Billie White

Butler Journal of Undergraduate Research

No abstract provided.

The Butler-Tarkington Community Member Views On The Perceived Gentrification, Julio C. Trujillo, Jr., Ethan Daniels

Butler Journal of Undergraduate Research

No abstract provided.

Cyber Jihadism: An Analysis On How The Cyber Sphere Has Altered Islamic Terrorism, Simon Spangenberg

Butler Journal of Undergraduate Research

No abstract provided.

Parent Interaction Between An Infant With A Cochlear Implant And Additional Disabilities, Lillian J. Southern

Butler Journal of Undergraduate Research

No abstract provided.

Drowning In Depression: A Reading Of William Cowper’S “The Castaway”, Katrina B. Skalko

Butler Journal of Undergraduate Research

No abstract provided.

A Matter Of Perspective: Reportage Style In District 9 (2009), M. Mert Örsler

Butler Journal of Undergraduate Research

No abstract provided.

The Motivations And Perceived Benefits Of Student Participation In Dance Marathon, Emily J. Nettesheim

Butler Journal of Undergraduate Research

No abstract provided.

Border Security And Immigration Policy: The Fight Against Terrorism, Caroline Klenck

Butler Journal of Undergraduate Research

No abstract provided.

Comparison Of Patient Outcomes In A Pharmacist-Led Parenteral Antimicrobial Therapy Program, Zachary W. Howe, Lindsay Saum, Jennifer Mccann

Butler Journal of Undergraduate Research

No abstract provided.