Medicine and Health Sciences Commons^™

Occupational Therapist’S Role In Addressing Transition Support Through Life Skills, Rupa Parikh, Becki Cohill, Susan Macdermott

Summer 2020 Virtual OTD Capstone Symposium

The transition period from high school to postsecondary education has been shown to be a difficult time for youth, especially those with disabilities. The use of occupational therapists in transition services can positively affect a student's ability to attend postsecondary education. Guidance and support are necessary to teach these individuals life skills needed for future success in the transition to postsecondary education. This capstone project aims to assess the needs of students at the Winston school to identify occupational limitations in the area of life skills. Through identification of problem areas, a detailed program was created and implemented to meet …

Occupational Therapy And Accessibility In The Outdoors And Summer Camps, David M. Lewis, Susan Macdermott, Becki Cohill

Summer 2020 Virtual OTD Capstone Symposium

Opportunities for positive youth development (PYD) are promoted through both outdoor and camp experiences. The experiences provided by the outdoors and camps are ideal for developing physically, cognitively, socially, emotionally, and spiritually. These areas of PYD are further generalizable to several aspects of occupational performance and participation, while continuing to have benefits throughout the lifespan. While the outdoors and camps provide these valuable opportunities for development, the environments and contexts of these opportunities are often limiting factors for individuals with disabilities.

Utilizing an occupational therapy approach allows for further understanding of how to promote inclusion and accessibility practices in these …

Occupational Therapy’S Role In Addressing Sensory Deficits In Children With Behavioral Health Challenges Through Teacher Training, Devon A. Ayres, Becki Cohill, Susan Macdermott, Mark Wilson

Summer 2020 Virtual OTD Capstone Symposium

Sensory processing difficulties have been well-documented in children who have behavioral health challenges. Addressing a child’s sensory processing needs may decrease behaviors that disrupt occupational participation and thus leading to improved learning and better information retention. A review of current literature revealed that teachers who work with children with behavioral health challenges are not required to receive education in addressing sensory deficits in the classroom. This capstone project performed a needs assessment, exploring current teacher understanding of sensory processing and what role occupational therapy could play in providing training for teachers. The project also generated pertinent online teacher training modules …

Turning Everyday Activities Into Play: Building Relationships And Fostering Connections For Adopted And Foster Children, Marissa E. Siu, Becki Cohill, Susan Macdermott

Summer 2020 Virtual OTD Capstone Symposium

Turning Everyday Activities into Play is a program that was created for foster children, adopted children, and individuals who work with this population in the community. This program uses everyday activities to foster the connection between children and adults. The goal of this program is to use the power of play to support regulation and build stronger bonds and relationships by turning everyday activities into play.

The Effect Of A Parental Diagnosis Of Cancer On The Occupational Performance Of Adolescent And Young Adult Offspring, Brianna Wong, Susan Macdermott, Becki Cohill, Pandora Patterson

Summer 2020 Virtual OTD Capstone Symposium

Objective: To gain an understanding on the current knowledge and practice of OTs relating to the occupational impact that a parental diagnosis of cancer can have on AYA offspring. In addition, to determine if there is occupational disruption or imbalance impacting AYAs whose parents have cancer and if OT is a good fit to treat this population.

Methods: A scoping literature review was conducted gathering relevant peer-reviewed articles, analyzing and creating themes with the current literature. In tandem with the scoping review, a qualitative study was conducted. Eight occupational therapists working in either an oncology care setting or pediatric setting …

Occupational Therapy's Role In Addressing Sex And Intimacy For Individuals With Progressive Neuromuscular Disorders, Lindsay N. Richards, Becki Cohill, Kathryn Ellis, Susan Macdermott

Summer 2020 Virtual OTD Capstone Symposium

Individuals with progressive neuromuscular disorders (PND); specifically, Parkinson’s disease (PD), Multiple Sclerosis (MS), Huntington’s Disease (HD), and Amyotrophic Lateral Sclerosis (ALS) often face physical, psychological, and social challenges related to sex and intimacy. Occupational therapy (OT) practitioners are experts in activity analysis and are equipped with unique knowledge of performance skills and client factors to address deficits in occupational performance. Though there is literature presenting the effects of PND on sexual occupations, a gap exists as it relates to qualitative data from the perspective of the individual and their partners.

A mixed-methods survey was conducted examining the lived experience of …

Face Masks, August 14, 2020, University Of Northern Iowa

UNI Response to COVID-19

A communication from the Forward Together Committee specifying that face masks are the preferred form of face covering required for all students and employees at UNI.

2020-08-14_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

2020-08-14_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of care (POC) tests, look for current infection. Serology (antibody) tests are used to look for the possibility of previous infection.
Source: Michigan Disease Surveillance System (MDSS) and Vital Records

The website contained the tables …

2020-08-14_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Data About Places. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Mechanisms Of T-Cell Exhaustion In Pancreatic Cancer., Didem Saka, Muazzez Gökalp, Betül Piyade, Nedim Can Cevik, Elif Arik Sever, Derya Unutmaz, Güralp O Ceyhan, Ihsan Ekin Demir, Hande Asimgil

Faculty Research 2020

T-cell exhaustion is a phenomenon that represents the dysfunctional state of T cells in chronic infections and cancer and is closely associated with poor prognosis in many cancers. The endogenous T-cell immunity and genetically edited cell therapies (CAR-T) failed to prevent tumor immune evasion. The effector T-cell activity is perturbed by an imbalance between inhibitory and stimulatory signals causing a reprogramming in metabolism and the high levels of multiple inhibitory receptors like programmed cell death protein-1 (PD-1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), and Lymphocyte-activation gene 3 (Lag-3). Despite the efforts to …

Dual Tasking Impairments Are Associated With Striatal Pathology In Huntington’S Disease, Johnny Lo, Alvaro Reyes, Timothy S. Pulverenti, Timothy J. Rankin, Danielle M. Bartlett, Pauline Zaenker, Grant Rowe, Kirk Feindel, Govinda Poudel, Nellie Georgiou‐Karistianis, Mel R. Ziman, Travis M. Cruickshank

Publications and Research

Background: Recent findings suggest that individuals with Huntington’s disease (HD) have an impaired capacity to execute cognitive and motor tasks simultaneously, or dual task, which gradually worsens as the disease advances.The onset and neuropathological changes mediating impairments in dual tasking in individuals with HD are unclear. The reliability of dual tasking assessments for individuals with HD is also unclear.

Objectives: To evaluate differences in dual tasking performance between individuals with HD (presymptomatic and prodromal) and matched controls, to investigate associations between striatal volume and dual tasking performance, and to determine the reliability of dual tasking assessments.

Methods: Twenty individuals with …

Does An Acl Autograft, Allograft Or Synthetic Graft Lead To Improved Long Term Knee Stability?, Parker Lanoue

Theses and Graduate Projects

Current literature surrounding anterior cruciate ligament (ACL) reconstruction outlines four primary classes of grafts used to replace the existing ACL. These classes include bone-patellar tendon-bone (BPTB) autografts, hamstring tendon (HT) autographs, allografts and synthetic grafts. Research has been conducted on each of these primary ACL reconstruction strategies and through this research we are looking to answer the question on which of these classes of ACL grafts in turn leads to the most improved long-term knee stability. In addition to analyzing these classes of grafts we will also inspect options along the non-surgical route to ACL repair, a more conservative approach, …

Prospective Home-Use Study On Non-Invasive Neuromodulation Therapy For Essential Tremor., Stuart H Isaacson, Elizabeth Peckham, Winona Tse, Olga Waln, Christopher Way, Melita T Petrossian, Nabila Dahodwala, Michael J Soileau, Mark Lew, Cameron Dietiker, Nijee Luthra, Pinky Agarwal, Rohit Dhall, John Morgan, Nicole Calakos, Theresa A Zesiewicz, Ejaz A Shamim, Rajeev Kumar, Peter Lewitt, Holly A Shill, Adam Simmons, Fernando L Pagan, Pravin Khemani, Jessica Tate, Brian Maddux, Lan Luo, William Ondo, Mark Hallett, Apoorva Rajagopal, Paula Chidester, Kathryn H Rosenbluth, Scott L Delp, Rajesh Pahwa

Articles, Abstracts, and Reports

Highlights: This prospective study is one of the largest clinical trials in essential tremor to date. Study findings suggest that individualized non-invasive neuromodulation therapy used repeatedly at home over three months results in safe and effective hand tremor reduction and improves quality of life for many essential tremor patients.

Background: Two previous randomized, controlled, single-session trials demonstrated efficacy of non-invasive neuromodulation therapy targeting the median and radial nerves for reducing hand tremor. This current study evaluated efficacy and safety of the therapy over three months of repeated home use.

Methods: This was a prospective, open-label, post-clearance, single-arm study with 263 …

Racism In Healthcare, Elizabeth Dwyer

Black History at UNM

Living with the daily experience of racism can have direct, adverse effects on the health and wellbeing of Black, Indigenous, and People of Color (BIPOC) communities. Dr. Tracie Collins, former Dean, UNM College of Population Health, and current Secretary of Health of New Mexico, and Dr. Felisha Rohan-Minjares, Professor, UNM’s Department of Family and Community Medicine, explain how bias and racism impact health, treatment, and outcomes.

Impact Of 5-Minute Preceptor Training On The Senior Nursing Student Perception Of Clinical Preceptor Feedback Effectiveness, Darla Daylene Smith

Articles, Abstracts, and Reports

Feedback is a tool that is often not utilized effectively. Clinical preceptors, when utilized, are the primary oversight for nursing students and should be able to provide feedback that is constructive and timely. Clinical preceptor feedback directly impacts the nurse generalists’ transition to practice which can increase competency levels by providing timely and quality feedback (Phillips, Mathew, Aktan, & Catano, 2017; Duteau, 2012). The purpose of this study was to determine if training clinical preceptors in the 5-Minute Preceptor method providing feedback to senior nursing students had an impact on the clinical teaching effectiveness. The research design was a comparative, …

Multiquantal Glutamate Release From Rod Photoreceptors, Cassandra L. Hays

Theses & Dissertations

Neurons communicate via Ca²⁺-dependent release of neurotransmitters packaged into vesicles (quanta). Some CNS neurons, especially sensory synapses, can release multiple vesicles at a time, increasing information transmission and overcoming the unreliability of a stochastic process. Ribbon-bearing neurons, including retinal photoreceptors, face the challenge of encoding sensory receptor potentials into an ever-changing train of vesicle release events. We studied release of glutamate using voltage clamp to measure anion currents activated during glutamate reuptake into presynaptic terminals (I_A(glu)) of salamander and mouse rods, finding that each employ distinct mechanisms for multiquantal release. In amphibian rods, we found that …

The Voices Of Professional Cheerleaders And Dancers: Perceptions Of Sexual Harassment, Melanie A. Hosty

Student Theses and Dissertations

Sexual harassment has persisted for decades but has recently gained attention, especially after the “Me Too” movement. Sexual harassment can happen to anyone, regardless of gender, age, race, or other characteristics. It can also occur anywhere, such as the workplace or in sport. This descriptive study looks at a sample of professional cheerleaders and dancers to determine their experience with sexual harassment. Through an open-ended questionnaire, they were given the opportunity to have their voices heard. Responses revealed who their harassers were, to whom they reported, and post-harassment symptoms, such as stress. Findings showed that fans and people within the …

Leveraging Aqueous Humor Dynamics And Ocular Biometrics For Improving Therapeutic Outcomes In Glaucoma, Vikas Gulati

Theses & Dissertations

Glaucoma laser and incisional surgical treatments are associated with a known risk of complications. The ability to better predict treatment outcomes and individualize treatment recommendations can enhance the benefit to risk ratio of a treatment option. The work presented in this dissertation explores the interplay of biometrics, race and aqueous humor dynamics and their influence on treatment outcomes. In the first chapter, we demonstrate that pre-operative aqueous humor dynamics (higher aqueous flow, lower outflow facility and lower uveoscleral outflow) are predictive of greater intraocular pressure lowering after selective laser trabeculoplasty. The second chapter describes significant race-based differences in aqueous humor …

Development Of Cholesterol Modified Rnai Polyplexes For Breast Cancer Therapy, Zhen Ye

Theses & Dissertations

Not available.

Urinary Bile Acid Indices As Diagnostic And Prognosic Biomarkers For Liver Diseases, Jawaher Alamoudi

Theses & Dissertations

Hepatobiliary diseases result in the accumulation of toxic bile acids (BA) in the liver, blood, and other tissues which may contribute to an unfavorable prognosis. We compared the urinary BA profile between 300 patients with hepatobiliary diseases vs. 103 healthy controls. Also, we investigated the use of the urinary BA profile to develop survival models to predict the prognosis of hepatobiliary diseases. The urinary BA profile, a set of non-BA parameters, and the adverse events of liver transplant and/or death were monitored in patients with cholestatic liver diseases for up to 7 years. The BA profile was characterized by calculating …

Non-Physician Led Hypertension Management, Poupak Moshayedi

MSN Capstone Projects

The importance of controlling and better management of hypertension cannot be overemphasized, and the need for task sharing and multidisciplinary approach has never been more significant than in chronic conditions like hypertension. With many complications that it causes and with the many classes of drugs that we have in controlling blood pressure, having only 24 percent of people being controlled shows a break in knowledge and patient care. The gap can be filled with nurse involvement and taking more ownership and responsibility in tackling high numbers with interventions that are proven to work. Getting patients involved and following up with …

Therapeutic Trem2 Activation Ameliorates Amyloid-Beta Deposition And Improves Cognition In The 5xfad Model Of Amyloid Deposition, Brittani R. Price, Tiffany L. Sudduth, Erica M. Weekman, Sherika Johnson, Danielle Hawthorne, Abigail E. Woolums, Donna M. Wilcock

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Triggering receptor expressed on myeloid cell-2 (TREM2) is a lipid and lipoprotein binding receptor expressed by cells of myeloid origin. Homozygous TREM2 mutations cause early onset progressive presenile dementia while heterozygous, point mutations triple the risk of Alzheimer's disease (AD). Although human genetic findings support the notion that loss of TREM2 function exacerbates neurodegeneration, it is not clear whether activation of TREM2 in a disease state would result in therapeutic benefits. To determine the viability of TREM2 activation as a therapeutic strategy, we sought to characterize an agonistic Trem2 antibody (AL002a) and test its efficacy and mechanism of action …

Impact Of Immunotherapy On The Survival Of Pancreatic Adenocarcinoma Patients: An Analysis Of The National Cancer Database, Saber A. Amin

Theses & Dissertations

Pancreatic adenocarcinoma (PDAC) represents 7.2% of all cancer deaths, and by 2030, it will become the second leading cause of death due to cancer. The median overall survival (OS) is 17-23 months in resectable and 4-6 months in metastatic PC [8-9]. The 5-year survival of resectable PC is 22%, and unresectable PC is 8%. A majority of patients treated with standard treatments such as surgery, chemotherapy, and radiation therapy eventually succumb to the disease due to widespread micrometastases at the time of diagnosis. Due to the minimal effect of the current treatments, novel treatment strategies such as immunotherapeutics have been …

Ligand-Installed Polymeric Nanocarriers For Combination Chemotherapy, Xinyuan Xi

Theses & Dissertations

Combination chemotherapy remains the mainstay of cancer treatment because such strategy targets different cell signaling pathways to decrease the likelihood of developing protective mechanisms by cancer cells, thereby delaying the onset of recurrence and prolonging the survival. The co-delivery of binary drug combination via a single nanocarrier provides benefits in reducing dose-limiting toxicities, improving the pharmacokinetic properties of the cargo, spatial-temporal synchronization of drug exposure, and synergistic therapeutic effects. Rational design of such regimen is crucial for maximizing the therapeutic effects since only certain drug ratios exposed to the target might be synergistic while other ratios exert additive or even …

Utilization Of Nurse Practitioners In States With Full Practice Authority: Does Geography Matter?, Jana Zwilling

Theses & Dissertations

Background: Over 80 million Americans reside in or are part of a population designated as Health Professional Shortage Areas (HPSAs). Of the primary medical HPSA areas designated in the U.S., 66.74% are located in rural or partially rural areas (HRSA, 2020). To combat this shortage, 23* states and Washington, D.C. have enacted full practice authority laws for nurse practitioners (NP). Over 60% of NPs work in communities of less than 250,000.

Problem: The variability and extent of utilization of NPs in states with full practice authority (FPA) is unknown. To ensure access to quality healthcare, nurse practitioners need to be …

Effect Of Nanofiller Coating And Loading On Facial Elastomer Physical Properties, Rahmi K. Aulia

Theses & Dissertations

Current materials used for facial prostheses are far from being desirable, and improved properties with “skin-like” feel are needed. This study evaluates property changes induced by sequential additions of uncoated and hydrophobic-coated nano-SiO₂ to polydimethylsiloxane (PDMS) and compares them with those measured for conventional submicron SiO₂-filled materials. Each filler type was sequentially added to vinyl-terminated PDMS at 0%, 0.5%, 5%, 10%, and 15% by weight. Tensile, tear, Durometer hardness, translucency and viscoelastic properties were evaluated, with hardness and translucency also evaluated following 3000 hours of outdoor weathering. Results demonstrated that 15% coated nano-SiO₂-filled PDMS materials …

Development Of Cxcr4-Inhibiting Rna Delivery Vectors For The Treatment Of Metastatic Pancreatic Cancer, Yu Hang

Theses & Dissertations

Pancreatic ductal adenocarcinoma (PDAC) is a growing medical problem associated with extensive metastasis and high mortality. Late diagnosis and complexity of the tumor microenvironment (TME) with severe hypoxia, desmoplasia, and hypovascular nature contributes to poor effectiveness of conventional chemotherapies. RNA interference (RNAi) holds great potential in the treatment of multiple genetic and acquired diseases, including PDAC. CXCR4/CXCL12 chemokine axis plays a pivotal role in PDAC TME remodeling to promote tumor proliferation, angiogenesis, metastasis, and chemoresistance. This project developed polymeric AMD3100 (PAMD) derivatives as dual-function vectors capable of simultaneously delivering small RNAs and blocking CXCR4/CXCL12 signaling.

Administration route plays pivotal role …

Identifying, Adapting, And Implementing A Weight Management Program In Rural Primary Care, Gwenndolyn Porter

Theses & Dissertations

Rural adults are at heightened risk for obesity, yet evidence‐based interventions lack consistent translation into clinical practice. This multi-phase study addresses this gap. First, a systematic review and meta-analysis of rural adult weight loss interventions were conducted to assess overall impact. Though few studies reported participant representativeness, meta‐analyses revealed a significant weight reduction among interventions. Second, 10 focus groups were conducted with primary care (PC) staff to determine the feasibility of implementing a weight-management program through PC. Differences in responses among rural, micropolitan, and metropolitan was also assessed. Thematic analyses revealed rural PC currently lacks the capacity to manage patient …

Exosomes Secreted Under Hypoxia Enhance Stemness In Ewing’S Sarcoma And Transform Microenvironment Cells, Matthew J. Kling

Theses & Dissertations

Intercellular communication between tumor cells and stroma within the hypoxic microenvironment promote aggressiveness and poor patient prognoses in ways that remain unclear. Here we show that hypoxic Ewing’s sarcoma (EWS) cells release exosomes that promote sphere formation, a stem-like phenotype, in EWS cells by enhancing survival and a cancer-associated phenotype in fibroblasts (CAFs). Given that hypoxia enriches for stem-like cells, we exposed EWS cells to hypoxia and hypoxic EWS-derived exosomes and assessed the stem cell phenotype. Hypoxia and hypoxic EWS-derived exosomewere found to enhance TIC formation in vitro and in vivo by reprogramming EWS cells. Analysis of the hypoxic exosomal …