Medicine and Health Sciences Commons^™

Otud4 Enhances Tgfβ Signalling Through Regulation Of The Tgfβ Receptor Complex, Patrick William Jaynes, Prasanna Vasudevan Iyengar, Sarah Kit Leng Lui, Tuan Zea Tan, Natali Vasilevski, Sarah Christine Elizabeth Wright, Giuseppe Verdile, Anand D. Jeyasekharan, Pieter Johan Adam Eichhorn

Research outputs 2014 to 2021

© 2020, The Author(s). Systematic control of the transforming growth factor-β (TGFβ) pathway is essential to keep the amplitude and the intensity of downstream signalling at appropriate levels. Ubiquitination plays a crucial role in the general regulation of this pathway. Here we identify the deubiquitinating enzyme OTUD4 as a transcriptional target of the TGFβ pathway that functions through a positive feedback loop to enhance overall TGFβ activity. Interestingly we demonstrate that OTUD4 functions through both catalytically dependent and independent mechanisms to regulate TGFβ activity. Specifically, we find that OTUD4 enhances TGFβ signalling by promoting the membrane presence of TGFβ receptor …

In Reply: Access-Site Complications In Transfemoral Neuroendovascular Procedures: A Systematic Review Of Incidence Rates And Management Strategies, Pascal Jabbour, Ahmad Sweid

Department of Neurosurgery Faculty Papers

No abstract provided.

Prevalence And Determinants Of Anemia Among Women Of Reproductive Age In Thatta Pakistan: Findings From A Cross-Sectional Study, Sumera Aziz Ali, Zahid Abbasi, Babar Shahid, Ghazal Moin, K Michael Hambidge, Nancy F. Krebs, Jamie E. Westcott, Elizabeth M. Mcclure, Robert L. Goldenberg, Sarah Saleem

Community Health Sciences

Background: Anemia is a major public health concern among women of reproductive age leading to high maternal mortality in low- and middle-income countries. Of the prior studies conducted in Pakistan, most focused on large urban areas and did not explore the determinants of anemia among women of reproductive age (WRA) across socio-demographic, dietary, reproductive, and biological domains. Thus, we aimed to study the prevalence and determinants of anemia among WRA in rural Pakistan.
Methods: We conducted a cross-sectional study in the Thatta district of Pakistan from September 2018 to January 2019 and enrolled 150 non-pregnant, married women. Data collectors administered …

Malnutrition And Food Insecurity In Child Labourers In Sindh, Pakistan: A Cross-Sectional Study, Meesha Iqbal, Zafar Fatmi, Kausar S. Khan, Yusra Jumani, Neelma Amjad, Asaad Ahmed Nafees

Community Health Sciences

Background: Child labour is common in low- and middle-income countries. Although child labour is widespread in Pakistan, no data are available on the health of child labourers.
Aims: This study aimed to assess the food security, food intake and nutritional status of child labourers aged 5-14 years working in lower Sindh, Pakistan.
Methods: Child labourers aged 5-14 years working in agriculture, manufacturing industry, hotels and restaurants, domestic work and migrant child labourers working in vegetable markets were recruited using a respondent-driven sampling technique. Sociodemographic and nutrition information was obtained by an interviewer questionnaire. The children's height and weight were measured …

Journal Club - Dapa-Hf Trial, Emma De Louw, Pgy-3

Department of Family & Community Medicine Presentations and Grand Rounds

No abstract provided.

The De Garengeot Hernia: A Case Report Of An Unusual Presentation Of Appendicitis., Davek Sharma, Jacob Katsnelson, Emmanuel Nwachuku, Jeffrey Kolff

Abington Jefferson Health Papers

INTRODUCTION: A De Garengeot hernia is defined by a femoral hernia containing the appendix. Acute appendicitis within a femoral hernia is an extremely rare surgical presentation and occurs in only 0.08-0.013% of cases as cited by the literature.

PRESENTATION OF CASE: A 64-year-old female presented to the Emergency Department of our hospital with acute onset of a right-sided groin bulge that occurred earlier that day after doing heavy lifting. Her workup revealed acute appendicitis contained within an incarcerated right femoral hernia. The patient underwent laparoscopic appendectomy with open femoral hernia repair. Intraoperatively, the appendiceal tip was incarcerated within the hernia …

Impact Of Metformin On Feeding, Behavior, And Metabolism In Drosophila Melanogaster., Erica E. Hassoun, Heba Kourhabi, Jason Bui Ho, Dae-Sung Hwangbo

Undergraduate Research Events

Metformin is a first-line drug used in the treatment of type II diabetes mellitus and is the 4th-most prescribed drug in the United States. It functions in lowering blood glucose levels and increasing insulin sensitivity. Despite its wide scale use, the degree to which it affects aspects of behavior and metabolism unrelated to diabetes is not fully understood.

Recent studies have attempted to fill this gap, particularly in the context of metformin’s impact on lifespan. We decided to extend this research by focusing on measurable behaviors as well as traits related to metabolism and physiology. Using the fruit fly Drosophila …

Demystifying Sensory Processing To Promote Effective Interprofessional And Caregiver Collaboration, Janis Leinfuss, Erin O'Hara

Student Journal of Occupational Therapy

Research shows collaboration and coaching with caregivers and educators positively impacts growth in occupational performance. Better understanding of this additional role that occupational therapy practitioners play; when working with children with sensory processing challenges, is vital to properly advocate for strategies and resources to help them reach their personal trajectory.

This article offers insight into the importance of removing professional jargon to facilitate effective interprofessional collaboration. Specific strategies for making coaching and training sessions for sensory processing content relatable and meaningful to educators and caregivers are also provided.

The Effect Of Artificial Aging And Surface Treatments On Microtensile Bond Strength Of Resin Cement To Hybrid Ceramics, Engy I. Hassan Shohdy, Shereen A. Nossair, Amina M. Hamdy

Future Dental Journal

Purpose: To assess the effect of aging and various surface treatments on the microtensile bond strength of resin cement to two hybrid esthetic materials. Materials and Methods: Zirconia-reinforced lithium silicate (Celtra Duo, Dentsply Sirona, United States) and hybrid resin nanoceramic (Cerasmart TM, GC Corporation, Japan) blocks were cut into plates of 3 mm thickness. Each ceramic material was surface treated either with hydrofluoric acid etching and silane or with sandblasting and silane. A dual-cured adhesive resin cement (Panavia TM V5, Kuraray, U.S.A.) was utilized to bond the composite resin plates to the surface treated ceramic plates. The ceramic-composite resin blocks …

Assessment Of Antibacterial Properties And Compressive Strength Of Copaiba Oil –Modified Glass Ionomer Cement Versus Nanosilver Or Nanogold-Modified Glass Ionomer Cements: An In-Vitro Study, Rania Ezzat Bayoumi Assistant Professor, Shaymaa Ibrahim Habib Assistant Professor

Future Dental Journal

Objectives: Evaluation of antibacterial activity of glass ionomer restorative material (GIC) after impregnation of copaiba oil, nanosilver (NanoAg) and nanogold (NanoAu) and their consequent effect on the compressive strength. Methodology: The different antibacterial solutions were added to Fugi IX GI liquid at various concentrations; 50 μL, 100 μL, 150 μL, 200 μL and 250 μL. Antibacterial activity against streptococcus mutans was evaluated by agar diffusion test (ADT) and direct contact test (DCT). Compressive strength was assessed according to ISO specifications. Bactericidal effect of the different investigated antibacterial agents on S. mutans biofilms was evaluated using Conofocal laser scanning microscope (CLSM). …

Biofilm Forming Ability Of Bacteria Isolated From Dental Caries: With Reference To Streptococcus Species, Sonali Kaustubh Ambulkar, Vidya Tale, Abhijit Jadhav, Komal Kulkarni

Future Dental Journal

Dental caries is formed by the group of microorganisms attached to a tooth surface embedded in a matrix of polymers. Biofilm plays an important role in the development of dental caries, plaque and other periodontal diseases. The present study is aimed to isolate, identify and characterize bacteria from dental caries. The ability of biofilm formation of these isolates was confirmed by Congo red agar method, Tube method and Microtitre plate method. High biofilm-forming bacteria were identified by 16S rRNA sequencing. Streptococcus mutans, Streptococcus anginosus, Enterococcus faecalis and Rothia dentocariosa are the predominant biofilm forming bacteria associated with dental caries.

Using Cold Plasma As A Surface Treatment With Peek Dental Implant: A Case Series”., Mohamed Dohiem, Hebatalla Mahmoud El Afandy

Future Dental Journal

Background: Polyetheretherketone (PEEK) is a material that can be used instead of normal titanium implants. PEEK is considered inert and biocompatible, however, it has been shown to possess low surface energy and that leads to decreased osteointegration with bone, Recent researches have focused on increasing the bioactivity of PEEK by modifying the surface by chemical and physical means such as plasma treated surfaces.

The Purpose of this article to evaluate peek dental implant with cold plasma surface treatment

Materials In this case series an immediately loaded peek dental implant, treated with plasma surface activation method, was used to replace anterior …

Effect Of The Parotid Salivary Gland On Calcium And Amylase Enzyme Levels In Blood And Its Influence On Bone Healing In Albino Rats (Histological And Radiographic Study), Medhat A. El-Zainy, Ahmed Mahmoud Halawa, Radwa Taher Elsharkawy

Future Dental Journal

The healing potential of bone is influenced by a variety of biochemical, cellular, hormonal and pathological mechanisms. As previous studies stated that parotid salivary glands may have endocrinal role, the aim of this study was to evaluate the effect of parotidectomy on bone healing and on calcium and amylase enzyme levels in blood. The rats were divided into two groups; control and experimental group. The control group was subjected to unilateral surgical mandibular defects, while the experimental group was subjected to the same procedure in addition to bilateral surgical removal of the parotid glands. Each of the control and experimental …

Internal Fit Of Lithium Disilicate And Resin Nano-Ceramic Endocrowns With Different Preparation Designs, Heba Darwish, Tarek Salah Morsi, Ayman Galal El Dimeery

Future Dental Journal

Purpose: Investigation of different central cavity designs on internal fit of endocrowns fabricated from two materials. Materials and methods: Forty maxillary premolars were endodontically treated and divided into 8 groups [n ¼ 5]: LS10, LS6, LD10, LD6, ES10, ES6, ED10 and ED6 (“L” restored with Lava™ Ultimate [resin nano ceramic], “E” restored with IPS e.max® CAD [lithium disilicate], “S” shallow depth [3 mm], “D” extended depth [5 mm], “6”-degree and “10”-degree axial wall divergence). All restorations were fabricated using CEREC CAD/CAM system. Samples were tested for internal fit using CBCT imaging (Next Generation i-CAT scanner) before and after adaptation. Data …

Effect Of Different Beverages On The Color Stability And Microhardness Of Cad/Cam Hybrid Versus Feldspathic Ceramic Blocks: An In-Vitro Study, Dalia A. Saba, Rania A. Salama, Rasha Haridy

Future Dental Journal

Purpose: Aim of the present investigation is to study and compare effects of common beverages on color stability and microhardness of CAD/CAM hybrid versus feldspathic ceramic-blocks. Materials and methods: Two commercially-available CAD/CAM ceramic-blocks: Hybrid (Vita Enamic, En) and Feldspathic (Vitablocs MarkII, Vm) were selected for this study. Total of 18 specimens of each material were prepared. Baseline measurements for color and microhardness were taken using spectrophotometer and Vickers microhardness tester respectively. Specimens of each material were divided into 3 groups according to immersion medium; coffee, red wine or distilled water (control). Final measurements were taken after 28-days of immersion. Color …

Microtensile Bond Strength And Scanning Electron Microscopic Evaluation Of Zirconia Bonded To Dentin Using Two Self-Adhesive Resin Cements; Effect Of Airborne Abrasion And Aging, Reem Gamal, Yasser F. Gomaa, Mostafa A. Abdellatif

Future Dental Journal

Aim of the study: This in vitro study was conducted to evaluate the microtensile bond strength (mTBS) of surface treated zirconia bonded to dentin specimens using two aged contemporary dual cured selfadhesive resin cements. Materials and methods: Sixty cuboidal-shaped zirconia ceramic specimens were obtained using CAD/ CAM system. Specimens were divided into two equal main groups; 30 specimens each, gp A in which specimens did not receive any further surface treatment & gp B in which only one surface of each specimen was airborne abraded. Each group was then divided into two equal groups; 15 each, according to the type …

Evaluation Of Piezotomed Alveolar Ridge Splitting With Stereolithographic Surgical Guide For Implant Placement (Clinical Study), Mohamed N. Mustafa, Abdelaziz F. Khalil, Lydia N. Melek

Future Dental Journal

Introduction: Narrow dentoalveolar ridges remain a serious challenge for the successful placement of endosseous implants. Several techniques for this procedure may be considered, such as guided bone regeneration, bone block grafting, and ridge splitting for bone expansion. The ridge split procedure provides a quicker and a more reliable method. Advances in technology, Stereolithography allow fabrication of surgical guide from 3D generated models for precise implant placement. Objectives: Evaluation of minimally invasive ridge splitting procedure aided with surgical guide. Materials and methods: A clinical study was performed on a total of 7 patients with mandibular free end saddle. The sample was …

Efficacy Of Transforming Growth Factor- B On Development Of Ameloblasts And Odontoblasts In Tooth Germ Of Young Albino Rat, Medhat Ahmed El-Zainy, Khaled Nour El-Haddad, Raneem Farouk Obeid

Future Dental Journal

Transforming growth factors were known as secreted factors that induced the growth of nontransformed cells. The study investigating the growth response of ameloblasts and odontoblasts to TGF-b. Four adult male and 12 adult female albino rats were used in this study. Mating took place between them. Female rats were divided into two groups each group consist of 6 rats: group I (control) rats were injected with 0.1 m1 phosphate buffer saline every two days from the first day till the labor time. Their offspring were considered the control group. Group II were injected intramuscular with TGF-b 40 ng dissolved in …

Comparing Topical Fluoride Application, Laser Irradiation And Their Combined Effect On Remineralisation Of Enamel, Gehan G. Allam, Aya Fahim Abdel Aziz

Future Dental Journal

The aim of the study was to verify whether subablative Er:YAG laser irradiation combined with fluoride application could provide a significantly greater inhibition of enamel demineralization histologically using Polarized light microscopy and to and to compare microhardness of enamel around orthodontic brackets after treatment by either fluoride, laser, or both. Material and methods: eighty freshly extracted premolars were randomly assigned to four groups after bonding: (A) control, (B) irradiated by Er: YAG laser& Voco Bifluoride 10™ varnish, (C) treated by Voco Bifluoride 10™ varnish, (D) irradiated by Er: YAG laser before pH cycle. Carieslike lesions were created by pH-cycling. At …

Assessment Of Students' Knowledge And Perception Of Pain And Antiinflammatory Drug Therapy In Dental Schools In Saudi Arabia, Saleh F. Alqifari

Future Dental Journal

Objective: Comprehensive knowledge in medication therapy and safety is an important skill for healthcare providers to master. Effective and safe use of pain and anti-inflammatory medications in teaching dental clinics requires a comprehensive knowledge base of the various drug agents. The purpose of this study is to assess the knowledge and perception of student dentists in various dental schools in Saudi Arabia in the use of pain and anti-inflammatory drug therapies. This study could help identify common areas for collaboration and improvement in healthcare delivery between pharmacy and dental medicine in Saudi Arabia. Methods: 328 student dentists enrolled in traditional …

Motivational Reasons For Choosing Dentistry As A Professional Career & Factors Affecting Specialty Choice Among Final Year Dental Students, Noha S. Kabil, Gehan G. Allam, Ola M. Abd El-Geleel

Future Dental Journal

The study aimed to evaluate factors affecting the choice of dentistry as a career as well as the choice of future specialty among senior dental students registered in British University of Egypt (BUE), during the academic year 2016/2017. A questionnaire form was downloaded from the students learning forum (e-learning), the students were then asked to fill up the form and hand it in during class. Results: Out of 200, 181 students responded to the survey, with a response rate of 90.5%. 67% of the students chose dentistry according to their own will, 20.1% due to family pressure, while only 12.8% …

Is Immersion In Mint Oil Or Apple Vinegar Solution A Valid Antifungal Approach For Acrylic Soft Liners?, Mehtab H. Deyab, Basma El. Awady, Nahed G. Bakir

Future Dental Journal

Objectives: In-vitro assessment of the validity of immersion in mint oil or apple vinegar solutions as antifungal approach for acrylic soft liners. Materials and methods: Sixty disc-shaped specimens: 9mm in diameter and 2mm in length, and sixty cylinders: 12.5mm in diameter and 20mm in length of Vertex-Dental Heat-cured acrylic soft liner were prepared for antifungal activity and resilience measurements respectively. Specimens were divided into three groups; twenty in each, for immersion in mint oil, apple vinegar and distilled water (control). The groups were divided into four subgroups, five in each, for the different immersion periods: one day, one week, three …

Comparison Of Translucency For Different Thicknesses Of Recent Types Of Esthetic Zirconia Ceramics Versus Conventional Ceramics … (In Vitro Study), Esraa Al-Juailaa, Essam Osman, Lucette Segaana, Mohammed Shrebatya, Ehab A. Farghaly

Future Dental Journal

Purpose: To compare the translucency of 6 different types of ceramic material using three different thicknesses. Materials and methods: Square shaped specimens were cut from different types of ceramics with variable translucencies (e.max CAD HT, e.max CAD LT, ultra-translucency zirconia, top-translucency zirconia, supertranslucency zirconia and high-translucency zirconia). Total samples of 144 specimens were divided into 6 main groups according to material; each group was divided into 3 subgroups according to thickness used (0.4, 0.6 and 1 mm). Using spectrophotometer each specimen was tested three times against white and black background and the average was taken to calculate translucency parameter (TP). …

Effect Of Surface Protection, Staining Beverages And Aging On The Color Stability And Hardness Of Recently Introduced Uncoated Glass Ionomer Restorative Material, Dalia Mohamed Abdel-Hamid, Gouda Mahmoud, Fatma M. El-Sharkawy, Eman Aly Abou Auf

Future Dental Journal

Aim: Evaluation of the effect of coating, staining beverages and aging on the color stability and hardness of recently introduced glass ionomer (GI) restorative material and to determine whether there was a correlation between these two variables. Materials and methods: Two commercially available conventional GI restorative materials were used; Ketac™ Universal Aplicap™ and Ketac™ Fil Plus Aplicap™ GI restoratives. A total of 84 disc-shaped specimens (5×2 mm) were prepared and divided into 3 main groups (n=28). Fifty six specimens were prepared from Ketac Universal Aplicap where half of them was coated (CU) and the other half was uncoated (U) and …

Characterization Of Nano-Hydroxyapatite Silica Gel And Evaluation Of Its Combined Effect With Solcoseryl Paste On Bone Formation: An Experimental Study In New Zealand Rabbits, Dalia Mohamed Abdel-Hamid, Safa F. Abdel El-Ghani, Mohamed M. Khashaba

Future Dental Journal

Objective: Characterization of nano-hydroxyapatite (n-HAp) silica gel bone substitute and evaluation of its combined effect with Solcoseryl paste on bone formation experimentally in New Zealand rabbits. Materials and methods: Characterization of the n-HAp silica gel granules (NanoBone®, Artoss GmbH, German) was done by the SEM, EDX analysis and TEM. Simulated bone defect (10×5×1 mm) was constructed from metallic mold to standardize the amount of the grafting materials. Two defects (10×5×1 mm) were created in the parietal bones of 12 New Zealand White rabbits. The rabbits were randomly divided into 4 groups with 3 rabbits/group (n=6 defects/group). Group (C): The defects …

Effect Of Veneering Techniques And Subsequent Aging On Translucency Of Bilayered Zirconia, Mohamed El-Agwany, Marwa Mohamed Wahsh, Tarek Salah Morsi

Future Dental Journal

Purpose: this study compared the translucency of zirconia specimens veneered with different veneering techniques, and compared the change in translucency after aging. Materials and methods: Fifty slice specimens (0.50 ± 0.01mm thick) were fabricated of IPS e.maxZirCAD core material, and ZL1 IPS e.maxZirLiner (0.10-mm thick) was layered. The specimens were randomly divided into five groups (n=10/group). Group Ι (traditional layering technique) was veneered (0.60 mm) by condensing and sintering IPS e.max Ceram low-fusing nano-fluorapatite veneering porcelain; Group ΙΙ (High translucency press on technique) was veneered (0.60 mm) by heat-pressing HT IPS e.maxZirPressfluorapatite glass-ceramic ingots; Group ΙΙΙ (Low translucency press on …

Intraoral Characterization Of Monolithic Ceramics: The “Triple R” Protocol, Amr S. El-Etreby

Future Dental Journal

A successful life like dental ceramic restoration should be able to blend harmoniously with the adjacent natural teeth. This could be achieved by mimicking and duplicating the natural teeth color, translucency, as well as the surface characterization of natural teeth. Shade matching is an important and a difficult task in mimicking natural teeth that usually leads to unreliable and inconsistent results. Still, a small percent of human teeth shade cannot be matched by available commercial shade guides. The presence of a chair side CAD/CAM system in the dental office eliminates the presence of laboratory steps and hence saving time and …

In Vivo Comparative Study Between Different Light Activated Bleaching Systems In Terms Of Color And Sensitivity, Maha El-Baz, Kariem Aboulenien

Future Dental Journal

No abstract provided.

Studying Some Mechanical Properties Of Maxillofacial Silicone Elastomer Before And After Incorporation Of Intrinsic Pigments And Artificial Aging, Noor M. Shihab, Faiza M. Abdul-Ameer

Future Dental Journal

No abstract provided.

Effect Of 15% Carbamide Peroxide Bleaching Gel On Color Of Class V Resin Composite Restoration, Ahmed Z. Elhoshya, Kariem Abouelenein, Maha A. Elbazb

Future Dental Journal

Objective: To investigate effect of 15% carbamide peroxide bleaching gel on color of Class V resin composite restoration. Materials and methods: 60 class V cavities were made in maxillary premolars Teeth were randomly divided into four groups of 15 specimens each (2 control and 2 experimental or bleached groups). Group A to be restored with light nanocomposite resin (Filtek Z350 XT) with no post-restoration bleaching procedure (control). Group B to be restored with light nanocomposite resin (Filtek Z350 XT, with post-restoration bleaching procedure (Experimental). Group C to be restored with microhybrid resin (Filtek 250 XT) with no post-restoration bleaching procedure …