Medicine and Health Sciences Commons^™

Covid-19 And Nutrition, Emelia Zukowski

Honors Senior Capstone Projects

Many individuals who contract COVID-19 and experience poor outcomes are also found to be deficient in certain vitamins and minerals. As a result, many nutrients have been related to improved outcomes for patients suffering from COVID-19. While it is not proven that increased intake of any one vitamin or mineral can prevent COVID-19, the supplementation of specific vitamins or minerals such as vitamin C, vitamin D, zinc, and magnesium could impact the risk of getting COVID-19 and the severity of cases of COVID-19. Positive benefits are expected from this relationship because certain vitamins and minerals have been known to support …

Novel Application Of Graphene Oxide Based-Biosensor Utilizing Crispr/Dcas9 For Rapid Detection Of Antibiotic Resistance Genes, Joel Omage

Masters Theses & Specialist Projects

Antibiotic resistance is one of the biggest public health challenges globally. To combat this threat, we have designed a method for the facile and rapid detection of antibiotic resistance gene (ARG) in bacteria. We utilized an emerging tool termed the clusters of regularly interspaced short palindromic repeats (CRISPR) in complex with deactivated CRISPR associated proteins (dCas9) on conjugated 2-dimensional graphene oxide (GO) sheets. Nuclease-deactivated Cas9 in complex with customized single guided RNA (sgRNA) was used for the target DNA recognition. The sgRNA was easy to design and we demonstrated that it is complementary to its target sequence by performing a …

Celebration Of A Milestone, Komal M. Patel

be Still

A first-year osteopathic medical student, Harsh Patel, has dreamed of starting medical school for as long as he can remember. This is a photo of him at his White Coat ceremony at NSU.

Ua3/10 President's Messages - Fall Semester, Wku President's Office - Caboni

WKU Administration Documents

President's Message emails sent by Timothy Caboni to faculty & staff during fall semester, 2020.

• Big Red Restart
• Bowling Green/Warren County Coronavirus Workgroup
• Climbing to Greater Heights – Strategic Plan
• COVID-19 – Campus Climate Survey – Personnel Searches – Homecoming
• COVID-19 Escalation
• Diversity, Equity & Inclusion Work Group
• End of Semester
• Faculty/Staff Open Forum & Convocation
• Fall Semester – Big Red Restart
• Healthy on the Hill
• Healthy on the Hill – Graves Gilbert Clinic
• Hilltopper Guarantee: WKU’s Commitment to the Commonwealth
• Salary Reductions

Empowering Nurses Of Minority In The Face Of Incivility And Bullying: Through The Lens Of Phenomenology, Corrine Floyd

Dissertations

Abstract

Up to 85% of nurses have reported exposure to incivility in the workplace (Hunt & Marini, 2012). The often-subtle nature of incivility toward nurses in a minority population may partially explain why it remains a problem. Healthcare organizations realize the need for civility to counter the high turnover rate, staff shortages, and low job satisfaction reported by nurses, but lack understanding of how nurses of a minority population perceive incivility and bullying. This study aimed to answer the research question how do nurses with minority representation experience incivility and bullying versus empowerment in the workplace? A descriptive phenomenological design …

A Second Cohort Of Chd3 Patients Expands The Molecular Mechanisms Known To Cause Snijders Blok-Campeau Syndrome, Theodore G Drivas, Dong Li, Divya Nair, Joseph T Alaimo, Mariëlle Alders, Janine Altmüller, Tahsin Stefan Barakat, E Martina Bebin, Nicole L Bertsch, Patrick R Blackburn, Alyssa Blesson, Arjan M Bouman, Knut Brockmann, Perrine Brunelle, Margit Burmeister, Gregory M Cooper, Jonas Denecke, Anne Dieux-Coëslier, Holly Dubbs, Alejandro Ferrer, Danna Gal, Lauren E Bartik, Lauren B Gunderson, Linda Hasadsri, Mahim Jain, Catherine Karimov, Beth Keena, Eric W Klee, Katja Kloth, Baiba Lace, Marina Macchiaiolo, Julien L Marcadier, Jeff M Milunsky, Melanie P Napier, Xilma R Ortiz-Gonzalez, Pavel N Pichurin, Jason Pinner, Zoe Powis, Chitra Prasad, Francesca Clementina Radio, Kristen J Rasmussen, Deborah L Renaud, Eric T Rush, Carol Saunders, Duygu Selcen, Ann R Seman, Deepali N Shinde, Erica D Smith, Thomas Smol, Lot Snijders Blok, Joan M Stoler, Sha Tang, Marco Tartaglia, Michelle L Thompson, Jiddeke M Van De Kamp, Jingmin Wang, Dagmar Weise, Karin Weiss, Rixa Woitschach, Bernd Wollnik, Huifang Yan, Elaine H Zackai, Giuseppe Zampino, Philippe Campeau, Elizabeth Bhoj

Paediatrics Publications

There has been one previous report of a cohort of patients with variants in Chromodomain Helicase DNA-binding 3 (CHD3), now recognized as Snijders Blok-Campeau syndrome. However, with only three previously-reported patients with variants outside the ATPase/helicase domain, it was unclear if variants outside of this domain caused a clinically similar phenotype. We have analyzed 24 new patients with CHD3 variants, including nine outside the ATPase/helicase domain. All patients were detected with unbiased molecular genetic methods. There is not a significant difference in the clinical or facial features of patients with variants in or outside this domain. These additional patients further …

Delay In Diagnosis Of Patients With Head-And-Neck Cancer In Canada: Impact Of Patient And Provider Delay., S Kassirian, A Dzioba, S Hamel, K Patel, A Sahovaler, D A Palma, N Read, V Venkatesan, A C Nichols, J Yoo, K Fung, A Mendez, S D Macneil

Paediatrics Publications

Background: Head-and-neck cancers (hncs) often present at an advanced stage, leading to poor outcomes. Late presentation might be attributable to patient delays (reluctance to seek treatment, for instance) or provider delays (misdiagnosis, prolonged wait time for consultation, for example). The objective of the present study was to examine the length and cause of such delays in a Canadian universal health care setting.

Methods: Patients presenting for the first time to the hnc multidisciplinary team (mdt) with a biopsy-proven hnc were recruited to this study. Patients completed a survey querying initial symptom presentation, their previous medical appointments, and length of time …

Proceedings Of The 2019 Canadian Inflammatory Myopathy Study Symposium: Clinical Trial Readiness In Myositis., Valérie Leclair, Océane Landon-Cardinal, Rohit Aggarwal, Nick Bansback, Craig Campbell, Brian M Feldman, Martin Jarry, Suzan Mcnamara, Barbara White, Marie Hudson

Paediatrics Publications

The Canadian Inflammatory Myopathy Study (CIMS) is a multicenter prospective cohort recruiting in 8 centers across Canada. One of the aims of CIMS is to conduct and participate in clinical trials in autoimmune inflammatory myopathies (AIM). Conducting clinical trials in rare diseases such as AIM presents challenges. During this symposium, experts in the field presented different solutions to successfully conduct clinical trials in AIM, including the importance of collaboration and careful trial design, as well as training and mentoring of young investigators.

Parental Online Information Access And Childhood Vaccination Decisions In North America: Scoping Review, Sarah Ashfield, Lorie Donelle

Nursing Publications

Background: Immunizing children throughout their early years prevents the spread of communicable disease and decreases the morbidity and mortality associated with many vaccine-preventable diseases. Searching online allows individuals rapid access to health information. Objective: The purpose of this review was to develop an understanding of the existing literature of parents’ online health information-seeking behaviors to inform their vaccination choices for their children and to identify gaps in the literature around parents’ use of online health information and their vaccination choices. Methods: A scoping review of peer-reviewed literature from Canada and the United States was performed. The following databases were utilized …

A Consensus Guide To Using Functional Near-Infrared Spectroscopy In Posture And Gait Research, Jasmine C. Menant, Inbal Maidan, Lisa Alcock, Emad Al-Yahya, Antonio Cerasa, David J. Clark, Eling D. De Bruin, Sarah Fraser, Vera Gramigna, Dennis Hamacher, Fabian Herold, Roee Holtzer, Meltem Izzetoglu, Shannon Lim, Annette Pantall, Paulo Pelicioni, Sue Peters, Andrea L. Rosso, Rebecca St George, Samuel Stuart, Roberta Vasta, Rodrigo Vitorio, Anat Mirelman

Physical Therapy Publications

Background: Functional near-infrared spectroscopy (fNIRS) is increasingly used in the field of posture and gait to investigate patterns of cortical brain activation while people move freely. fNIRS methods, analysis and reporting of data vary greatly across studies which in turn can limit the replication of research, interpretation of findings and comparison across works.

Research question and methods: Considering these issues, we propose a set of practical recommendations for the conduct and reporting of fNIRS studies in posture and gait, acknowledging specific challenges related to clinical groups with posture and gait disorders.

Results: Our paper is organized around three main sections: …

Genetic And Epigenetic Profiling Of Brca1/2 In Ovarian Tumors Reveals Additive Diagnostic Yield And Evidence Of A Genomic Brca1/2 Dna Methylation Signature, Erfan Aref-Eshghi, Jacob D. Mcgee, Victor P. Pedro, Jennifer Kerkhof, Alan Stuart, Peter J. Ainsworth, Hanxin Lin, Michael Volodarsky, Catherine Meg Mclachlin, Bekim Sadikovic

Paediatrics Publications

Poly-ADP-ribose-polymerase inhibitor (PARPi) treatment is indicated for advanced-stage ovarian tumors with BRCA1/2 deficiency. The “BRCAness” status is thought to be attributed to a tumor phenotype associated with a specific epigenomic DNA methylation profile. Here, we examined the diagnostic impact of combined BRCA1/2 sequence, copy number, and promoter DNA methylation analysis, and evaluated whether genomic DNA methylation patterns can predict the BRCAness in ovarian tumors. DNA sequencing of 172 human tissue samples of advanced-stage ovarian adenocarcinoma identified 36 samples with a clinically significant tier 1/2 sequence variants (point mutations and in/dels) and 9 samples with a CNV causing a loss of …

Covid-19 In Sub-Saharan Africa: Impacts On Vulnerable Populations And Sustaining Home-Grown Solutions, Lauren J. Wallace, Elysée Nouvet, Robert Bortolussi, Joshua A. Arthur, Eugenia Amporfu, Eric Arthur, Kofi Bobi Barimah, Bernard Aristide Bitouga, Harriet Chemusto, Joseph Ikechebelu, Ngozi Joe-Ikechebelu, Mandy Kader Kondé, Jean Damascene Kabakambira, Gabriel Kyomba Kalombe, Diana M.S. Karanja, Eveline Thobias Konje, Sekou Kouyate, Gojjam Limeneh, Felicien Munday Mulopo, Mary Ndu, Eric Ochomo, Oriokot Francis, Oumy Thiongane, Jeremiah Seni, S. Mohammed Sheriff, Douglas Singini

Health Studies Publications

© 2020, The Canadian Public Health Association. This commentary draws on sub-Saharan African health researchers’ accounts of their countries’ responses to control the spread of COVID-19, including social and health impacts, home-grown solutions, and gaps in knowledge. Limited human and material resources for infection control and lack of understanding or appreciation by the government of the realities of vulnerable populations have contributed to failed interventions to curb transmission, and further deepened inequalities. Some governments have adapted or limited lockdowns due to the negative impacts on livelihoods and taken specific measures to minimize the impact on the most vulnerable citizens. However, …

Appraisal Of Clinical Practice Guideline: Shoulder Pain And Mobility Deficits: Adhesive Capsulitis, Sanaa A. Alsubheen, Joy C. Macdermid

Bone and Joint Institute

No abstract provided.

Correspondence: Reply To Hadidi Et Al, Vanitha Arumugam, Joy C. Macdermid

Bone and Joint Institute

No abstract provided.

Medical Comorbidities And Functional Dependent Living Are Independent Risk Factors For Short-Term Complications Following Osteotomy Procedures About The Knee, Eric J. Cotter, Anirudh K. Gowd, Daniel D. Bohl, Alan Getgood, Brian J. Cole, Rachel M. Frank

Bone and Joint Institute

© The Author(s) 2018. Objective: To characterize rates and risk factors for adverse events following distal femoral osteotomy (DFO), high tibial osteotomy (HTO), and tibial tubercle osteotomy (TTO) procedures. Design: Patients undergoing DFO, HTO, or TTO procedures during 2005 to 2016 were identified in the American College of Surgeons National Surgical Quality Improvement Program. Rates of adverse events were characterized for each procedure. Demographic, comorbidity, and procedural factors were tested for association with occurrence of any adverse events. Results: A total of 1,083 patients were identified. Of these, 305 (28%) underwent DFO, 273 (25%) underwent HTO, and 505 (47%) underwent …

Anticytokine Therapies In Severe Coronavirus Disease 2019 Should Be Informed By Detailed Inflammatory Profiling And Specific Therapeutic Targets, Douglas Fraser

Data and Test Instruments

No abstract provided.

Aci-35 And Aadvac1 Active Immunotherapy As Preventative Treatment Options For Chronic Traumatic Encephalopathy, Emily C. Boehlein

Selected Honors Theses

One of the most common, as well as one of the most dangerous injuries amongst athletes today is mild traumatic brain injury (mTBI), commonly known as concussion. Aside from physical symptoms such as nausea, dizziness, and headaches; concussions have can have longterm effects on brain physiology. A common neurological disease that can result from multiple concussions is Chronic Traumatic Encephalopathy (CTE), characterized by symptoms such as severe depression, anxiety, confusion, and aggression; amongst others.1 On the cellular level, CTE is classified by a unique pathway that leads to the hyperphosphorylation of tau protein and subsequent clumping of tau-containing neurofibrillary tangles …

Can Viruses Cause Lupus?, Stephen I. Reeder

Selected Honors Theses

Like so many autoimmune diseases, the exact cause of systemic lupus erythematosus (SLE) remains unknown. Evidence points to both genetics and environment playing roles in the onset of the disease, but neither acts independent of the other. Genetics are the easier of the two to study with recent advances in the field making it easier to isolate genes shared by individuals with the disease. However, genetic studies reveal that there is almost certainly an environmental component to the development of SLE. The underlying pathology and existing research on environmental contributors to the development of SLE suggest that viruses could potentially …

Alumni Journal - Volume 91, Number 3, Loma Linda University School Of Medicine

Alumni Journal, School of Medicine

Editorials
2 | From the Editor
4 | From the President
7 | From the Dean

News
8 | Alumni News + This and That
10 | APC Preview
14 | AIMS Report
16 | School of Medicine News
18 | Students
20 | Department Reports: Transplant Surgery: Michael de Vera, MD (chief)

Missions
22 | Mission Stories: Trained to Heal, Choosing to Serve
24 | Haiti: Scott Nelson '96
28 | Nepal: Jonathon Thorp '12
30 | Honduras: Joel Mundall '06
32 | Zambia: Janie Yoo '06
34 | Chad: Andrew Trecartin '11
36 | Cameroon: Trixy Franke '06 …

The Effects Of E-Vapor On The Pathogenesis Of Rheumatoid Arthritis Mouse Models And Potential Implications For Future Generations, Christiana Daas

Selected Honors Theses

Rheumatoid arthritis is the most prevalent autoimmune disease. Rheumatoid arthritis (RA) has no cure, and the direct cause of the disease is still unknown. The two leading hypotheses concerning its etiology are based on the effects of HLA-DRB1 gene expression, and cigarette smoke. Conjunctively, the use of vaping devices amongst adolescents has increased significantly since introduced in 2007. There is no long-term data on the effects of e-vapor and its aerosols on bodily health. Cigarette smoke is the most noteworthy environmental factor contributing to RA therefore the question is raised as to whether or not vaping relates to rheumatoid arthritis …

Underfeeding Patients With Critical Illness: Making Sense Of Recent Data, Jacklyn C. Hook, Patricia M. Sheean

Parkinson School of Health Sciences and Public Health

Nutrition support is recognized as an important component of care for patients with critical illness. Providing energy and protein at estimated requirements is thought to prevent or decrease the likelihood of disease-related malnutrition. However, short-term calorie restriction may be advantageous in this setting. Using PubMed, we conducted a search for studies of “permissive underfeeding” or “hypocaloric feeding” for patients with critical illness to evaluate relevant outcomes. Of the initial 137 studies, 32 papers were evaluated, and 16 papers met all eligibility criteria. The results support a benefit or neutral impact on nutrition support-related complications, yet conflicting findings on mortality and …

Assessment And Management Of Dehydration, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

The Influence Of Autonomic Function On Pain Modulation Before And After Exercise And Cognitive Task In Fibromyalgia, Abdulaziz Awali

Dissertations (1934 -)

Fibromyalgia (FM) is a chronic pain condition characterized by widespread pain. People with FM have alterations in autonomic function compared to healthy individuals. Exercise can decrease pain in people with FM, however some people with FM experience pain exacerbation when initiating exercise. Whether variability in pain at rest and following exercise is related to altered autonomic function, including the potential implications with other stressful events such as mental math, is not known. This dissertation aimed at investigating: 1) the relation between cardiovascular autonomic function and central pain facilitation and inhibition, measured by temporal summation of pain (TS) and conditioned pain …

Tools, Techniques And Teamwork: Transferring New Technologies For Wildlife Management, Conservation And Economic Development, John Eisemann, Gail Keirn

United States Department of Agriculture Wildlife Services: Staff Publications

Did you ever wonder who invented radio telemetry? Or breakaway snares? What about the bird repellent methyl anthranilate or the livestock protection collar? These and many other tools used in wildlife damage management resulted from creative thinking by biologists, technicians, researchers and managers working to solve complex wildlife issues. Over the past 90 years, these “aha moments” within the U.S. Department of Agriculture’s Wildlife Services program have ranged from developing novel scare devices, traps and vaccines to exploiting an animal’s visual capabilities to stop unwanted behaviors. Once discovered, these unique ideas may lead to practical, feasible and cost-effective wildlife damage …

Prediction Of Opioid-Induced Respiratory Depression On Inpatient Wards Using Continuous Capnography And Oximetry: An International Prospective, Observational Trial., Ashish K Khanna, Sergio D Bergese, Carla R Jungquist, Hiroshi Morimatsu, Shoichi Uezono, Simon Lee, Lian Kah Ti, Richard D Urman, Robert Mcintyre, Carlos Tornero, Albert Dahan, Leif Saager, Toby N Weingarten, Maria Wittmann, Dennis Auckley, Luca Brazzi, Morgan Le Guen, Roy Soto, Frank Schramm, Sabry Ayad, Roop Kaw, Paola Di Stefano, Daniel I Sessler, Alberto Uribe, Vanessa Moll, Susan J Dempsey, Wolfgang Buhre, Frank J Overdyk, Marianne Tanios, Eva Rivas, Miluska Mejia, Kavita Elliott, Assad Ali, Juan Fiorda-Diaz, Ruben Carrasco-Moyano, Ana Mavarez-Martinez, Alicia Gonzalez-Zacarias, Cory Roeth, January Kim, Alan Esparza-Gutierrez, Carleara Weiss, Chiahui Chen, Arata Taniguchi, Yuko Mihara, Makiko Ariyoshi, Ichiro Kondo, Kentaro Yamakawa, Yoshifumi Suga, Kohei Ikeda, Koji Takano, Yuuki Kuwabara, Nicole Carignan, Joyce Rankin, Katherine Egan, Lakeisha Waters, Ming Ann Sim, Lyn Li Lean, Qi En Lydia Liew, Lawrence Siu-Chun Law, James Gosnell, Salina Shrestha, Chisom Okponyia, Mohammed H Al-Musawi, María José Parra Gonzalez, Claudia Neumann, Vera Guttenthaler, Olja Männer, Achilles Delis, Anja Winkler, Bahareh Marchand, Frauke Schmal, Fuad Aleskerov, Mohammedumer Nagori, Muhammad Shafi, Gloria Mcphee, Cynthia Newman, Elizabeth Lopez, Sabrina Ma Har, Moumen Asbahi, Kim Nordstrom Mccaw, Maurice Theunissen, Valerie Smit-Fun

Articles, Abstracts, and Reports

BACKGROUND: Opioid-related adverse events are a serious problem in hospitalized patients. Little is known about patients who are likely to experience opioid-induced respiratory depression events on the general care floor and may benefit from improved monitoring and early intervention. The trial objective was to derive and validate a risk prediction tool for respiratory depression in patients receiving opioids, as detected by continuous pulse oximetry and capnography monitoring.

METHODS: PRediction of Opioid-induced respiratory Depression In patients monitored by capnoGraphY (PRODIGY) was a prospective, observational trial of blinded continuous capnography and oximetry conducted at 16 sites in the United States, Europe, and …

The Comparison Between Delayed Cord Clamping And Immediate Cord Clamping On Fetal Outcomes, Aydan Drake, Kelsey Mawyer

Fall Showcase for Research and Creative Inquiry

The research question that is being asked is, are newborns, who are delivered vaginally, that have their umbilical cord clamped immediately after birth at a disadvantage for improved health benefits compared to newborns who received delayed cord clamping? Delayed cord clamping is a procedure performed after the baby is born in which healthcare providers delay clamping the umbilical cord in order to allow blood from the placenta to be transferred into the newborn. Delayed cord clamping is performed 25 seconds to 5 minutes after birth. The study used gathered data from 9 university hospitals in 4 different countries and involved …

For People Over The Age 65, Does The Use Of Cloth Face Masks Help Lower The Transmission Of Covid-19 Compared With The Use Of Gaiter Masks?, Abigail Mills, Joelle Harthun

Fall Showcase for Research and Creative Inquiry

The COVID19 pandemic has generated rumors and conspiracy theories: -Origin of the virus, its modes of transmission, the options for preventing and treating it, and the actions governments have taken (Vraga & Jacobsen, 2020). Which is more effective: cloth face masks or neck gaiters. Gaiter masks fit very loosely around the mouth and nose. According to Massachusetts Institute of Technology, your mask should fully cover your nose and chin: preventing breathing in any droplets (Schive, 2020). Masks need to be tightly woven; you cannot see the individual fibers when holding it up to the light (Schive, 2020). Masks should be …

In Adult Patients Receiving Wound Care, What Is The Effect Of Wound Care Given Using Clean Technique, Compared To Wound Care Given Using Sterile Technique On Efficient Wound Healing Process Without Complications?, Lily Gamble, Madison Taylor

Fall Showcase for Research and Creative Inquiry

We chose to research the effect of wound care given using clean technique compared to sterile technique. According to the US Center for Disease Control, nearly 1.7 million patients suffer from hospital-acquired infections and more than 98,000 of these patients die every year (Haque, et al., 2018). Due to this frightening statistic, we wanted to further understand and discover if using a certain technique when caring for wounds plays a major role in preventing complications, such as infections. We chose our topic based on our learning experiences in clinical and the classroom setting. We then found credible sources from medical …

Patient Education Effects On Health Outcomesâ , Hannah Lawrence

Fall Showcase for Research and Creative Inquiry

The purpose of this research is to discuss how patient education can benefit patient health outcomes. Patient education involves helping patients to gain a better understanding of their condition, procedures, and how lifestyle choices can impact their health. There are many ways in which a patient can be educated. This includes discussions with the healthcare team and the use of other materials such as pamphlets, group classes, or videos. My research question is: How can patients with cardiovascular disease utilize tools gained from patient education improve health outcomes compared to those who have had inadequate education to prevent the development …

Do Adults With Bacterial Infections Develop Less Of An Antibiotic Resistance With Iv Antibiotics Than With Oral Antibiotics After A Full Course Of Treatment?, Navvy Stevens, Taylor-Erin Evitts

Fall Showcase for Research and Creative Inquiry

This study was conducted in order to discover if patients develop less of an antibiotic resistance when going through intravenous antibiotics, compared to using oral antibiotics. This concept was created due to the fact that many people that are prescribed oral antibiotics, do not finish the entire prescribed amount. When this occurs, it gives the bacteria that the antibiotics were trying to get rid of, have the chance to adapt and become resistant to the particular antibiotic. By discovering the percentage of people who were prescribed antibiotics that never finished a round of them, it aids in narrowing down what …