Medicine and Health Sciences Commons^™

Gli3 Utilizes Hand2 To Synergistically Regulate Tissue-Specific Transcriptional Networks., Kelsey H Elliott, Xiaoting Chen, Joseph Salomone, Praneet Chaturvedi, Preston A Schultz, Sai K Balchand, Jeffrey D Servetas, Aimée Zuniga, Rolf Zeller, Brian Gebelein, Matthew T Weirauch, Kevin A Peterson, Samantha A Brugmann

Faculty Research 2020

Despite a common understanding that Gli TFs are utilized to convey a Hh morphogen gradient, genetic analyses suggest craniofacial development does not completely fit this paradigm. Using the mouse model (Mus musculus), we demonstrated that rather than being driven by a Hh threshold, robust Gli3 transcriptional activity during skeletal and glossal development required interaction with the basic helix-loop-helix TF Hand2. Not only did genetic and expression data support a co-factorial relationship, but genomic analysis revealed that Gli3 and Hand2 were enriched at regulatory elements for genes essential for mandibular patterning and development. Interestingly, motif analysis at sites co-occupied …

2020-10-02_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

2020-10-02_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

The Acute Effects Of The Atypical Dissociative Hallucinogen Salvinorin A On Functional Connectivity In The Human Brain, Manoj K. Doss, Darrick G. May, Matthew W. Johnson, John M. Clifton, Sidnee L. Hedrick, Thomas E. Prisinzano, Roland R. Griffiths, Frederick S. Barrett

Pharmaceutical Sciences Faculty Publications

Salvinorin A (SA) is a κ-opioid receptor agonist and atypical dissociative hallucinogen found in Salvia divinorum. Despite the resurgence of hallucinogen studies, the effects of κ-opioid agonists on human brain function are not well-understood. This placebo-controlled, within-subject study used functional magnetic resonance imaging for the first time to explore the effects of inhaled SA on strength, variability, and entropy of functional connectivity (static, dynamic, and entropic functional connectivity, respectively, or sFC, dFC, and eFC). SA tended to decrease within-network sFC but increase between-network sFC, with the most prominent effect being attenuation of the default mode network (DMN) during the …

Microglia Prevent Beta-Amyloid Plaque Formation In The Early Stage Of An Alzheimer's Disease Mouse Model With Suppression Of Glymphatic Clearance, Weixi Feng, Yanli Zhang, Ze Wang, Hanrong Xu, Ting Wu, Charles Marshall, Junying Gao, Ming Xiao

Physical Therapy Faculty Publications

BACKGROUND: Soluble beta-amyloid (Aβ) can be cleared from the brain through various mechanisms including enzymatic degradation, glial cell phagocytosis, transport across the blood-brain barrier, and glymphatic clearance. However, the relative contribution of each clearance system and their compensatory effects in delaying the pathological process of Alzheimer's disease (AD) are currently unknown.

METHODS: Fluorescent trace, immunofluorescence, and Western blot analyses were performed to compare glymphatic clearance ability and Aβ accumulation among 3-month-old APP695/PS1-dE9 transgenic (APP/PS1) mice, wild-type mice, aquaporin 4 knock out (AQP4^−/−) mice, and AQP4^−/−/APP/PS1 mice. The consequence of selectively eliminating microglial cells, or downregulating apolipoprotein …

Nad Metabolism In Male Reproductive Aging, Mirella L. Meyer-Ficca

Funded Research Records

No abstract provided.

A Narrative Analysis Of Psychological Adjustments Of Professionals Transitioning To Work Following Cerebral Vascular Accident (Cva), Mabel Munachiso Korie

Theses & Dissertations

This research study was a narrative analysis of the psychological adjustment of professionals transitioning to work after a cerebral vascular accident, commonly known as a stroke. The purpose of this research was to explore the psychological adjustment of professionals who returned to work after a stroke following their subsequent rehabilitation. This has been an important subject because stroke research predominantly addresses older adults, which means that there has not been enough information on the experience of affected working-age professionals. The Roy Adaptation Model and Social Cognitive Theory were the frameworks for the study. The data collected were from audio-recorded and …

Ionomic Profiling Of Pericardial Fluid In Ischemic Heart Disease, Noman Khan, Satwat Hashmi, Amna Jabbar Siddiqui, Sabiha Farooq, Shahid Ahmed Sami, Nageeb Basir, Syedah Saira Bokhari, Hasanat Sharif, Sanaullah Junejo, Syed Ghulam Musharraf

Department of Biological & Biomedical Sciences

Metals are essential cofactors that play a crucial role in heart function at the cell and tissue level. Information regarding the role of metals in the pericardial fluid and its ionome in ischemic heart disease (IHD) is limited. We aimed to determine the association of elements in pericardial fluid and serum samples of IHD patients and their correlation with systolic and diastolic function. IHD patients have been studied with systolic and diastolic dysfunction categorized on the basis of echocardiographic parameters. We measured concentrations of sixteen elements in the pericardial fluid and serum of 46 patients obtained during open heart surgery …

Cesarean Delivery And Infant Cortisol Regulation, Leticia D. Martinez, Laura M. Glynn, Curt A. Sandman, Deborah A. Wing, Elysia Poggi Davis

Psychology Faculty Articles and Research

Background:
Cesarean delivery reduces the risk of infant and maternal morbidity and mortality when medically indicated, however, the cesarean delivery rate is estimated to be two to three times higher than medically necessary. The World Health Organization and American College of Obstetricians and Gynecologists have expressed concern over the high rates of cesarean delivery, citing evidence that cesarean delivery has negative short- and long-term consequences for the health of the infant, mother, and for future pregnancies. Infants delivered by cesarean are at an increased risk of metabolic disease and immune dysfunction throughout the lifespan. Preliminary research suggests that the …

Measuring Service Quality And Assessing Its Relationship To Contraceptive Discontinuation: A Prospective Cohort Study In Pakistan And Uganda, Karen T. Chang, Nirali M. Chakraborty, Amanda M. Kalamar, Waqas Hameed, Ben Bellows, Karen A. Grépin, Agha Xaher Gul, Sarah E K. Bradley, Lynn M. Atuyambe, Dominic Montagu

Community Health Sciences

Background: The quality of contraceptive counseling that women receive from their provider can influence their future contraceptive continuation. We examined (1) whether the quality of contraceptive service provision could be measured in a consistent way by using existing tools from 2 large-scale social franchises, and (2) whether facility quality measures based on these tools were consistently associated with contraceptive discontinuation.
Methods: We linked existing, routinely collected facility audit data from social franchise clinics in Pakistan and Uganda with client data. Clients were women aged 15-49 who initiated a modern, reversible contraceptive method from a sampled clinic. Consented participants completed an …

Variation In Early Number Skills And Mathematics Achievement: Implications From Cognitive Profiles Of Children With Or Without Turner Syndrome, Sarah L Lukowski, Emily R Padrutt, Kyriakie Sarafoglou, Judith L. Ross, Jennifer R Law, Rachel E Olson, Michèle M M Mazzocco

Department of Pediatrics Faculty Papers

Individuals with Mathematics Learning Disabilities have persistent mathematics underperformance but vary with respect to their cognitive profiles. The present study examined mathematics ability and achievement, and associated mathematics-specific numerical skills and domain-general cognitive abilities, in young children with Turner syndrome compared to their matched peers. We utilized two independent peer groups so that group comparisons would account for verbal skills, a hypothesized strength of girls with Turner syndrome, and nonsymbolic magnitude comparison skills, a hypothesized difference of girls with Turner syndrome. This individual matching approach afforded characterization of mathematics profiles of girls with Turner syndrome and girls without Turner syndrome …

Sexual Dimorphism In The Meiotic Requirement For Prdm9: A Mammalian Evolutionary Safeguard., Natalie Powers, Beth L Dumont, Chihiro Emori, Raman Akinyanju Lawal, Catherine Brunton, Kenneth Paigen, Mary Ann Handel, Ewelina Bolcun-Filas, Petko M. Petkov, Tanmoy Bhattacharyya

Faculty Research 2020

In many mammals, genomic sites for recombination are determined by the histone methyltransferase PRMD9. Some mouse strains lacking PRDM9 are infertile, but instances of fertility or semifertility in the absence of PRDM9 have been reported in mice, canines, and a human female. Such findings raise the question of how the loss of PRDM9 is circumvented to maintain fertility. We show that genetic background and sex-specific modifiers can obviate the requirement for PRDM9 in mice. Specifically, the meiotic DNA damage checkpoint protein CHK2 acts as a modifier allowing female-specific fertility in the absence of PRDM9. We also report that, in the …

Age And Genetic Background Modify Hybrid Male Sterility In House Mice., Samuel J Widmayer, Mary Ann Handel, David L Aylor

Faculty Research 2020

Hybrid male sterility (HMS) contributes to reproductive isolation commonly observed among house mouse (Mus musculus) subspecies, both in the wild and in laboratory crosses. Incompatibilities involving specific Prdm9 alleles and certain Chromosome (Chr) X genotypes are known determinants of fertility and HMS, and previous work in the field has demonstrated that genetic background modifies these two major loci. We constructed hybrids that have identical genotypes at Prdm9 and identical X chromosomes, but differ widely across the rest of the genome. In each case, we crossed female PWK/PhJ mice representative of the M. m. musculus subspecies to males from …

Infant Hearing Screening During The Sars Cov-2 Pandemic – A Descriptive Study In A Tertiary Health Care Centre In Southern India, Dr.Susmitha Sriperumbudur

Kasturba Medical College, Mangalore Theses and Dissertations

No abstract provided.

“A Study To Assess The Correlation Between Level Of Critical Thinking Ability And Competency In Performing Neurological Assessment Among Nursing Students Of Selected Nursing Colleges Of Udupi District, Karnataka”, Piyali Saha

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study entitled “A study to assess the correlation between the level of critical thinking ability and competency in performing neurological assessment among nursing students of selected Nursing colleges of Udupi district” was conducted by Ms. Piyali Saha in partial fulfillment of the degree of master of science in nursing at Manipal College of Nursing, Manipal Academy of Higher Education, Manipal. The objectives of the study were to identify the level of critical thinking ability among nursing students, assess the level of knowledge regarding neurological assessment among nursing students, assess the level of competency in performing neurological assessment …

“A Comparative Study To Assess The Attitude And Self-Reported Practices Of Self- Medication Among The Healthcare And Non- Healthcare Undergraduate Students Of Selected Institutions Of A University In Udupi District, Karnataka”, Ilakkiya P

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT “A comparative study to assess the attitude and self-reported practices of self- medication among the healthcare and non-healthcare undergraduate students of selected Institutions of a University in Udupi District, Karnataka” was carried out by Ms. Ilakkiya P in partial fulfillment of the requirement for the degree of Master of Science in Nursing at Manipal College of Nursing, Manipal Academy of Higher Education, Manipal, Karnataka. The objective of the study was to compare the attitude and self-reported practices of self-medication among the undergraduate students of healthcare and non- healthcare. The study aimed at assessing the attitude on self-medication in terms …

"“A Cross-Sectional Study To Assess The Body Mechanics, Perceived Musculoskeletal Problems And Health-Seeking Behaviour Among Construction Workers Of Udupi District.” ", Raghavendra Nayak

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A study to assess the body mechanics perceived musculoskeletal problems and health-seeking behaviour of construction workers of Udupi district was carried out at construction sites in selected panchayats of Udupi district by Mr Raghavendra Nayak for the award of MSc Nursing Degree. The objectives of the study were to assess the body mechanics, to find the perceived musculoskeletal problems and health-seeking behaviour among construction workers of Udupi district. The modified conceptual framework adopted from Irwin Rosen Stocks Health- Belief Model 1950 for the study. Through quantitative research approach cross-sectional survey design used in the study. The simple random sampling …

“A Study To Assess The Perception Towards Tobacco Consumption And Its Usage Among The Auto Rickshaw Drivers Of Udupi District, Karnataka”, Shakeel Mohan

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study entitled “A study to assess the perception towards tobacco consumption and its usage among the auto rickshaw drivers of Udupi District, Karnataka” was carried out by Mr. Shakeel Mohan in partial fulfilment of the requirement for the degree of Master of Science in Nursing at Manipal College of Nursing, Manipal, MAHE, Manipal. The objectives of the study were to assess the perception towards tobacco consumption among the auto rickshaw drivers as measured by rating scale on perception towards tobacco consumption, to determine the usage of tobacco products among the auto rickshaw drivers as measured by tobacco …

“A Study To Assess The Knowledge On Post Exposure Prophylaxis And Adherence To Needle Stick Injury Prevention Measures Among Nurses In Selected Hospitals Of Udupi Taluk, Karnataka”, Kusumavathi .

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study titled, “A study to assess the knowledge on post exposure prophylaxis and adherence to needle stick injury prevention measures among nurses in selected hospitals of Udupi taluk.” was conducted by Ms. Kusumavathi in partial fulfillment of the requirements for the award of Master of Science in Nursing at Manipal College of Nursing Manipal, MAHE. The objectives of the study were to assess the knowledge on post exposure prophylaxis among nurses, and to observe adherence to needle stick injury preventive measures. The conceptual framework adopted for the study was based on health belief model” by Hochbaum, Rosenstock …

The Role Of Rapid Diagnostic Point Of Care Igg/Igm Antibody Tests In The Diagnosis Of Sars-Cov-2 Infection, Nishita Tripathi, Daniya Sheikh, Dawn Balcom

The University of Louisville Journal of Respiratory Infections

Background: Current testing of symptomatic patients for SARS-CoV-2 involves the use of nucleic acid amplification tests, also known as genetic, RNA, or polymerase chain reaction (PCR), to detect viral RNA. The initial use of point of care (POC) antibody tests, also known as serological tests, in the management of SARS-CoV-2 infection was limited. In this review, we determine the significance of POC antibody serological tests and explore their possible role in the diagnosis and management of patients infected with the SARS-CoV-2 virus.

Methods: A literature search was conducted in Google Scholar, PubMed, and Embase, supplemented by searching the Centers for …

“Awareness About Rights Of Older Adults, Attitude And Perception Towards Ageism Among The College Students Of Udupi District: A Descriptive Cross-Sectional Study”, Angel Thomas

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study entitled: “Awareness about rights of older adults, attitude and perception towards ageism among the college students of Udupi district: A descriptive cross-sectional study.” Ageing is an unavoidable and irreversible biological process which has its own advancements beyond the human control. Globally the ratio of the elderly population is growing rapidly, because of the medical advancements and decreased fertility ratio. It is important to protect the rights of the older adults to reduce the mistreatment against them. The objectives of the study were to determine the awareness level of the college students on the rights of the …

“ Life Style Factors Associated With Elevated Blood Pressure Among Working Women Of Selected Institutions Of Udupi Taluk: A Case Control Study.”, Priya Laveena Alva

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study entitled “Life style factors associated with elevated blood pressure among working women of selected institutions of Udupi Taluk: A case control study” was conducted by Ms Priya Laveena Alva in partial fulfilment of the requirement for the award of Master of Science in Nursing at Manipal College of Nursing, MAHE, Manipal. The objective of the study was to identify the lifestyle factors that contributed to elevated blood pressure among working women. The conceptual framework for the study was based on Kaoru Ishiwaka fishbone model 1968. A quantitative study with case control design was adopted for the …

" “A Study To Assess The Pattern Of Smartphone Usage, Smartphone Addiction And Associated Subjective Health Problems Among Nursing Students Of Selected Colleges Of Udupi District” ", Joyce Machado

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study titled “A study to assess the pattern of smartphone usage, smartphone addiction and associated subjective health problems among nursing students of selected colleges of Udupi District” was conducted by Joyce Machado in partial fulfilment of the requirement for the degree of Masters of science in Nursing at Manipal College of Nursing Manipal, Manipal Academy of Higher Education. The objectives of the study were to assess the pattern of smartphone usage, smartphone addiction, study habits and subjective health problems associated with smartphone usage, among nursing students. The conceptual framework used for the study was based on Technology …

"“A Descriptive Study To Assess The Knowledge And Attitude Towards Global Warming And Perceived Impacts Of Regional Climate Change On Health Among The Health Science Students Of Udupi District, Karnataka” ", Badaplin Rynjah

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study A descriptive study to assess the knowledge and the attitude towards Global warming and perceived impacts of regional climate change on health among the health science students of Udupi district, Karnataka was conducted by Ms Badaplin Rynjah as a partial fulfilment of the requirements for the degree of Master of Science in Nursing, at Manipal College of Nursing, MAHE, Manipal. The objectives of the study were to assess the knowledge on Global warming among the students of health science, attitude towards environmental protection and assess the perception on impact of regional climate change on health among …

Audiological Assessment In Infants With Hyperbilirubinemia, Dr.Saksham Dhawan

Kasturba Medical College, Mangalore Theses and Dissertations

No abstract provided.

Correlations Between The Radiation Dose To Cochlear And Sensorineural Hearing Loss In Head And Neck Cancer, Dr.Apoorva K. V

Kasturba Medical College, Mangalore Theses and Dissertations

No abstract provided.

Evaluation Of Outcome Of Acoustic Reflex Tests In Patients With Type 2 Diabetes Mellitus - A Cross Sectional Study, Dr.Puvvula Praneetha

Kasturba Medical College, Mangalore Theses and Dissertations

No abstract provided.

Lymphnode Recurrence In Papillary Carcinoma Thyroid Cases, Dr.Navya Parvathareddy

Kasturba Medical College, Mangalore Theses and Dissertations

No abstract provided.

The Relationship Between Alcohol Consumption, Academic Success, And Athletic Identity In Collegiate Student-Athletes, Zoe Arnold, Hung-Ling (Stella) Liu

Health and Nutritional Sciences Faculty Publications

Upon entering college, students around the United States are exposed to alcohol and the potentially dangerous experiences and ef­fects that come with consuming alcohol. Whether the individual is a general col­lege student or a college student-athlete, the issues are prevalent. According to the 2014 United States Census, there are ap­proximately 23 million students attending U.S. colleges. According to the National Collegiate Athletic Association (NCAA), there are 460,000 student-athletes across the United States (NCAA, 2017). When National Association of Intercollegiate Athletics (NAIA) student-athletes are in­cluded, the overall number then surpasses 500,000. A student-athlete (SA) can be defined as an individual who …

Psychosocial Climates Differentially Predict 12- To 14-Year-Old Competitive Soccer Players’ Goal Orientations, E. Whitney G. Moore, Karen Weiller-Abels

Kinesiology, Health and Sport Studies

Youth’s likelihood of participating in sport increases when they maintain a focus on enjoyment, learning, and effort (i.e., task goal orientation) rather than how they compare to others and norms (i.e., ego goal orientation). Achievement goal theory research consistently illustrates the significant influence of leader-created motivational climates on their participants’ goal orientation adoption. However, the influence of caring climate perceptions by highly competitive adolescent athletes on their goal orientation adoption has yet to be examined. Thus, this study assessed how competitive, adolescent soccer players’ perceptions of the climate as caring, task-, and ego-involving predicted their adoption of task and ego …