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2020

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Articles 20551 - 20580 of 20666

Full-Text Articles in Medicine and Health Sciences

Evaluation Of A Remote Symptom Assessment And Management (Sam) System For People Receiving Adjuvant Chemotherapy For Breast Or Colorectal Cancer: Mixed Methods Study, Lisa Whitehead, Laura Emery, Deborah Kirk, Diane Twigg, Deborah Brown, Joanna Dewar Jan 2020

Evaluation Of A Remote Symptom Assessment And Management (Sam) System For People Receiving Adjuvant Chemotherapy For Breast Or Colorectal Cancer: Mixed Methods Study, Lisa Whitehead, Laura Emery, Deborah Kirk, Diane Twigg, Deborah Brown, Joanna Dewar

Research outputs 2014 to 2021

©Lisa Whitehead, Laura Emery, Deborah Kirk, Diane Twigg, Deborah Brown, Joanna Dewar. Background: The Symptom Assessment and Management (SAM) program is a structured, online, nurse-supported intervention to support symptom self-management in people receiving adjuvant chemotherapy post surgery for breast or colorectal cancer. Objective: The objective of this study was to describe the development, implementation strategy, and evaluation of the SAM system. Methods: The development of the SAM program involved 3 phases. In phase 1, the web app was developed through consultation with consumers and clinicians and of the literature to ensure that the system was evidence-based and reflected the realities …


The Influence Of Adaptive Challenge On Engagement Of Multidisciplinary Staff In Standardising Aseptic Technique In An Emergency Department: A Qualitative Study, Amanda Towell-Barnard, Susan Slatyer, Helen Cadwallader, Michelle Harvey, Susan Davis Jan 2020

The Influence Of Adaptive Challenge On Engagement Of Multidisciplinary Staff In Standardising Aseptic Technique In An Emergency Department: A Qualitative Study, Amanda Towell-Barnard, Susan Slatyer, Helen Cadwallader, Michelle Harvey, Susan Davis

Research outputs 2014 to 2021

Aims and objectives: To explore the challenge of engaging multidisciplinary staff in standardising aseptic technique (AT) in an emergency department (ED) in an Australian tertiary hospital, and to better understand the enablers and barriers to implementing practice change within this setting.

Background: Healthcare‐associated infections are the most common complication for patients in acute care. A clinical practice framework developed in the United Kingdom (UK) standardised AT practice to reduce potential infection risk. One Australian tertiary hospital drew upon this framework to similarly improve clinical practice. It was understood that standardising practice would require some practitioners only to revisit and demonstrate …


The Impact Of A Residential Camp On Grandchildren Raised By Grandparents: Grandparents’ Perspectives, J. Dare, R. Marquis, E. Wenden, S. Gopi, D. A. Coall Jan 2020

The Impact Of A Residential Camp On Grandchildren Raised By Grandparents: Grandparents’ Perspectives, J. Dare, R. Marquis, E. Wenden, S. Gopi, D. A. Coall

Research outputs 2014 to 2021

This research aimed to investigate grandparents’ perspectives on the impact of Leadership and Respite Camps, designed for children being raised by their grandparents, on their grandchildren. In-depth interviews were conducted with 34 grandparents whose grandchildren had participated in 1 of 3 camps held between September 2018 and January 2019, in Perth and the south-west of Western Australia. Findings highlighted how grandcarers’ perceived the camps created unique opportunities for grandchildren to share their experiences in a safe and supportive environment. Grandparents reported significant psychosocial benefits to their grandchild, including feeling they fitted in with their peers and were not alone in …


Validity And Reliability Of Methods To Determine Barbell Displacement In Heavy Back Squats: Implications For Velocity-Based Training, Brendyn B. Appleby, Harry Banyard, Prue Cormie, Stuart J. Cormack, Robert U. Newton Jan 2020

Validity And Reliability Of Methods To Determine Barbell Displacement In Heavy Back Squats: Implications For Velocity-Based Training, Brendyn B. Appleby, Harry Banyard, Prue Cormie, Stuart J. Cormack, Robert U. Newton

Research outputs 2014 to 2021

The purpose of this study was to investigate the validity and reliability of methods for determining barbell displacement during heavy back squats. Twelve well-trained rugby union players (mean ± SD 1 repetition maximum [1RM] 90° squat = 196.3 ± 29.2 kg) completed 2 sets of 2 repetitions at 70, 80, and 90% of 1RM squats. Barbell displacement was derived from 3 methods across 4 load categories (120–129, 140–149, 160–169, and 180–189 kg) including: a (a) linear position transducer (LPT) attached 65 cm left of barbell center, (b) 3D motion analysis tracking of markers attached to either end of a barbell, …


The External Validity Of A Novel Contract-Relax Stretching Technique On Knee Flexor Range Of Motion, Anthony D. Kay, Joshua Dixon, Liam D. Bligh, Anthony J. Blazevich Jan 2020

The External Validity Of A Novel Contract-Relax Stretching Technique On Knee Flexor Range Of Motion, Anthony D. Kay, Joshua Dixon, Liam D. Bligh, Anthony J. Blazevich

Research outputs 2014 to 2021

Introduction: Compromised joint range of motion (ROM) can negatively affect the capacity to perform activities of daily living in clinical populations. Recently, similar improvements in dorsiflexion ROM were reported following dynamometry‐based contract‐relax (CR) stretching and modified CR stretching technique (stretch‐return‐contract [SRC]) where the contraction phase was performed “off stretch.” As neither the impact of SRC on other muscle groups nor the ecological validity of SRC performed in an applied environment has been tested, the acute effects of both techniques in dynamometry‐ (CRdyna and SRCdyna) and field‐based (CRfield and SRCfield) environments were compared with the …


Power Output, Cadence, And Torque Are Similar Between The Forward Standing And Traditional Sprint Cycling Positions, Paul F. J. Merkes, Paolo Menaspà, Chris R. Abbiss Jan 2020

Power Output, Cadence, And Torque Are Similar Between The Forward Standing And Traditional Sprint Cycling Positions, Paul F. J. Merkes, Paolo Menaspà, Chris R. Abbiss

Research outputs 2014 to 2021

Purpose: Compare power output, cadence, and torque in the seated, standing, and forward standing cycling sprint positions.

Methods: On three separated occasions (ie, one for each position), 11 recreational male road cyclists performed a 14 seconds sprint before and directly after a high-intensity lead-up. Power output, cadence, and torque were measured during each sprint. Results: No significant differences in peak and mean power output were observed between the forward standing (1125.5 ± 48.5 W and 896.0 ± 32.7 W, respectively) and either the seated or standing positions (1042.5 ± 46.8 W and 856.5 ± 29.4 W; 1175.4 ± 44.9 W …


Liquid Biopsy In Ovarian Cancer Using Circulating Tumor Dna And Cells: Ready For Prime Time?, Du-Bois Asante, Leslie Calapre, Melanie Ziman, Tarek M. Meniawy, Elin S. Gray Jan 2020

Liquid Biopsy In Ovarian Cancer Using Circulating Tumor Dna And Cells: Ready For Prime Time?, Du-Bois Asante, Leslie Calapre, Melanie Ziman, Tarek M. Meniawy, Elin S. Gray

Research outputs 2014 to 2021

Liquid biopsies hold the potential to inform cancer patient prognosis and to guide treatment decisions at the time when direct tumor biopsy may be impractical due to its invasive nature, inaccessibility and associated complications. Specifically, circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) have shown promising results as companion diagnostic biomarkers for screening, prognostication and/or patient surveillance in many cancer types. In ovarian cancer (OC), CTC and ctDNA analysis allow comprehensive molecular profiling of the primary, metastatic and recurrent tumors. These biomarkers also correlate with overall tumor burden and thus, they provide minimally-invasive means for patient monitoring during clinical …


Association Of Suboptimal Health Status With Intestinal Microbiota In Chinese Youths, Qi Sun, Xizhu Xu, Jie Zhang, Ming Sun, Qiuyue Tian, Qihuan Li, Weijie Cao, Xiaoyu Zhang, Hao Wang, Jiaonan Liu, Jinxia Zhang, Xiaoni Meng, Lijuan Wu, Manshu Song, Hongqi Liu, Wei Wang, Youxin Wang Jan 2020

Association Of Suboptimal Health Status With Intestinal Microbiota In Chinese Youths, Qi Sun, Xizhu Xu, Jie Zhang, Ming Sun, Qiuyue Tian, Qihuan Li, Weijie Cao, Xiaoyu Zhang, Hao Wang, Jiaonan Liu, Jinxia Zhang, Xiaoni Meng, Lijuan Wu, Manshu Song, Hongqi Liu, Wei Wang, Youxin Wang

Research outputs 2014 to 2021

Suboptimal health status (SHS), a physical state between health and disease, is a subclinical and reversible stage of chronic disease. Previous studies have shown alterations in the intestinal microbiota in patients with some chronic diseases. This study aimed to investigate the association between SHS and intestinal microbiota in a case-control study with 50 SHS individuals and 50 matched healthy controls. Intestinal microbiota was analysed by MiSeq 250PE. Alpha diversity of intestinal microbiota in SHS individuals was higher compared with that of healthy controls (Simpson index, W = 2238, P = .048). Beta diversity was different between SHS and healthy controls …


Corrections To: The Effect Of Nordic Hamstring Exercise Intervention Volume On Eccentric Strength And Muscle Architecture Adaptations: A Systematic Journal Article And Meta-Analyses, Matthew Cuthbert, Nicholas Ripley, John J. Mcmahon, Martin Evans, G. Gregory Haff, Paul Comfort Jan 2020

Corrections To: The Effect Of Nordic Hamstring Exercise Intervention Volume On Eccentric Strength And Muscle Architecture Adaptations: A Systematic Journal Article And Meta-Analyses, Matthew Cuthbert, Nicholas Ripley, John J. Mcmahon, Martin Evans, G. Gregory Haff, Paul Comfort

Research outputs 2014 to 2021

No abstract provided.


Exercise Twice-A-Day Potentiates Markers Of Mitochondrial Biogenesis In Men, Victor Amorim Andrade-Souza, Thaysa Ghiarone, Andre Sansonio, Kleiton Augusto Santos Silva, Fabiano Tomazini, Lucyana Arcoverde, Jackson Fyfe, Enrico Perri, Nicholas Saner, Jujiao Kuang, Romulo Bertuzzi, Carol Gois Leandro, David John Bishop, Adriano Eduardo Lima‐Silva Jan 2020

Exercise Twice-A-Day Potentiates Markers Of Mitochondrial Biogenesis In Men, Victor Amorim Andrade-Souza, Thaysa Ghiarone, Andre Sansonio, Kleiton Augusto Santos Silva, Fabiano Tomazini, Lucyana Arcoverde, Jackson Fyfe, Enrico Perri, Nicholas Saner, Jujiao Kuang, Romulo Bertuzzi, Carol Gois Leandro, David John Bishop, Adriano Eduardo Lima‐Silva

Research outputs 2014 to 2021

Endurance exercise begun with reduced muscle glycogen stores seems to potentiate skeletal muscle protein abundance and gene expression. However, it is unknown whether this greater signaling responses is due to performing two exercise sessions in close proximity-as a first exercise session is necessary to reduce the muscle glycogen stores. In the present study, we manipulated the recovery duration between a first muscle glycogen-depleting exercise and a second exercise session, such that the second exercise session started with reduced muscle glycogen in both approaches but was performed either 2 or 15 hours after the first exercise session (so-called "twice-a-day" and "once-daily" …


Contralateral Effects By Unilateral Eccentric Versus Concentric Resistance Training, Wei-Chin Tseng, Kazunori Nosaka, Kuo-Wei Tseng, Tai-Ying Chou, Trevor C. Chen Jan 2020

Contralateral Effects By Unilateral Eccentric Versus Concentric Resistance Training, Wei-Chin Tseng, Kazunori Nosaka, Kuo-Wei Tseng, Tai-Ying Chou, Trevor C. Chen

Research outputs 2014 to 2021

Purpose: Unilateral resistance training increases muscle strength of the contralateral homologous muscle by the cross-education effect. Muscle damage induced by second eccentric exercise bout is attenuated, even when it is performed by the contralateral limb. The present study compared the effects of unilateral eccentric training (ET) and concentric training (CT) of the elbow flexors (EF) on maximal voluntary isometric contraction (MVC) strength and muscle damage of the contralateral untrained EF.

Methods: Young men were placed into ET, CT, ipsilateral repeated bout (IL-RB), and contralateral repeated bout (CL-RB) groups (n = 12 per group). The ET and CT groups performed …


Tnf-Block Genotypes Influence Susceptibility To Hiv-Associated Sensory Neuropathy In Indonesians And South Africans, Jessica Gaff, Fitri Octaviana, Prinisha Pillay, Huguette Gaelle Ngassa Mbenda, Ibnu A. Ariyanto, June Ann Gan, Catherine L. Cherry, Peter Kamerman, Simon M. Laws, Patricia Price Jan 2020

Tnf-Block Genotypes Influence Susceptibility To Hiv-Associated Sensory Neuropathy In Indonesians And South Africans, Jessica Gaff, Fitri Octaviana, Prinisha Pillay, Huguette Gaelle Ngassa Mbenda, Ibnu A. Ariyanto, June Ann Gan, Catherine L. Cherry, Peter Kamerman, Simon M. Laws, Patricia Price

Research outputs 2014 to 2021

HIV-associated sensory neuropathy (HIV-SN) is a disabling complication of HIV disease and antiretroviral therapies (ART). Since stavudine was removed from recommended treatment schedules, the prevalence of HIV-SN has declined and associated risk factors have changed. With stavudine, rs1799964*C (TNF-1031) associated with HIV-SN in Caucasians and Indonesians but not in South Africans. Here, we investigate associations between HIV-SN and rs1799964*C and 12 other polymorphisms spanning TNF and seven neighboring genes (the TNF-block) in Indonesians (n = 202; 34/168 cases) and South Africans (n = 75; 29/75 cases) treated without stavudine. Haplotypes were derived using fastPHASE and haplotype networks built with PopART. …


The Effect Of Nordic Hamstring Exercise Intervention Volume On Eccentric Strength And Muscle Architecture Adaptations: A Systematic Review And Meta-Analyses, Matthew Cuthbert, Nicholas Ripley, John J. Mcmahon, Martin Evans, G. Gregory Haff, Paul Comfort Jan 2020

The Effect Of Nordic Hamstring Exercise Intervention Volume On Eccentric Strength And Muscle Architecture Adaptations: A Systematic Review And Meta-Analyses, Matthew Cuthbert, Nicholas Ripley, John J. Mcmahon, Martin Evans, G. Gregory Haff, Paul Comfort

Research outputs 2014 to 2021

Background: Although performance of the Nordic hamstring exercise (NHE) has been shown to elicit adaptations that may reduce hamstring strain injury (HSI) risk and occurrence, compliance in NHE interventions in professional soccer teams is low despite a high occurrence of HSI in soccer. A possible reason for low compliance is the high dosages prescribed within the recommended interventions. The aim of this review was to investigate the effect of NHE-training volume on eccentric hamstring strength and biceps femoris fascicle length adaptations.

Methods: A literature search was conducted using the SPORTDiscus, Ovid, and PubMed databases. A total of 293 studies were …


Cerebrospinal Fluid Neurofilament Light Concentration Predicts Brain Atrophy And Cognition In Alzheimer's Disease, Kunal Dhiman, Veer Bala Gupta, Victor L. Villemagne, Dhamidhu Eratne, Petra L. Graham, Christopher Fowler, Pierrick Bourgeat, Qiao-Xin Li, Steven Collins, Ashley I. Bush, Christopher C. Rowe, Colin L. Masters, David Ames, Eugene Hone, Kaj Blennow, Henrik Zetterberg, Ralph N. Martins Jan 2020

Cerebrospinal Fluid Neurofilament Light Concentration Predicts Brain Atrophy And Cognition In Alzheimer's Disease, Kunal Dhiman, Veer Bala Gupta, Victor L. Villemagne, Dhamidhu Eratne, Petra L. Graham, Christopher Fowler, Pierrick Bourgeat, Qiao-Xin Li, Steven Collins, Ashley I. Bush, Christopher C. Rowe, Colin L. Masters, David Ames, Eugene Hone, Kaj Blennow, Henrik Zetterberg, Ralph N. Martins

Research outputs 2014 to 2021

Introduction
This study assessed the utility of cerebrospinal fluid (CSF) neurofilament light (NfL) in Alzheimer's disease (AD) diagnosis, its association with amyloid and tau pathology, as well as its potential to predict brain atrophy, cognition, and amyloid accumulation.
Methods
CSF NfL concentration was measured in 221 participants from the Australian Imaging, Biomarkers & Lifestyle Flagship Study of Ageing (AIBL).
Results
CSF NfL levels as well as NfL/amyloid β (Aβ42) were significantly elevated in AD compared to healthy controls (HC; P < .001), and in mild cognitive impairment (MCI) compared to HC (P = .008 NfL; P< .001 NfL/Aβ42). CSF NfL and NfL/Aβ42 differentiated AD from HC with an area under the receiver operating characteristic (ROC) curve (AUC) of 0.84 and 0.90, respectively. CSF NfL and NfL/Aβ42 predicted cortical amyloid load, brain atrophy, and cognition.
Discussion
CSF NfL is a biomarker of neurodegeneration, correlating with cognitive impairment and brain neuropathology.


A Broad Autism Phenotype Expressed In Facial Morphology, Diana Weiting Tan, Murray T. Maybery, Syed Zulqarnain Gilani, Gail A. Alvares, Ajmal Mian, David Suter, Andrew J. O. Whitehouse Jan 2020

A Broad Autism Phenotype Expressed In Facial Morphology, Diana Weiting Tan, Murray T. Maybery, Syed Zulqarnain Gilani, Gail A. Alvares, Ajmal Mian, David Suter, Andrew J. O. Whitehouse

Research outputs 2014 to 2021

Autism spectrum disorder is a heritable neurodevelopmental condition diagnosed based on social and communication differences. There is strong evidence that cognitive and behavioural changes associated with clinical autism aggregate with biological relatives but in milder form, commonly referred to as the ‘broad autism phenotype’. The present study builds on our previous findings of increased facial masculinity in autistic children (Sci. Rep., 7:9348, 2017) by examining whether facial masculinity represents as a broad autism phenotype in 55 non-autistic siblings (25 girls) of autistic children. Using 3D facial photogrammetry and age-matched control groups of children without a family history of ASD, we …


Compression Garments Reduce Muscle Movement And Activation During Submaximal Running, James R. Broatch, Ned Brophy-Williams, Elissa J. Phillips, Steven J. O'Bryan, Shona Halson, Shannon Barnes, David J. Bishop Jan 2020

Compression Garments Reduce Muscle Movement And Activation During Submaximal Running, James R. Broatch, Ned Brophy-Williams, Elissa J. Phillips, Steven J. O'Bryan, Shona Halson, Shannon Barnes, David J. Bishop

Research outputs 2014 to 2021

Purpose The purpose of this study was to investigate the effectiveness of sports compression tights in reducing muscle movement and activation during running. Methods A total of 27 recreationally active males were recruited across two separate studies. For study 1, 13 participants (mean ± SD = 84.1 ± 9.4 kg, 22 ± 3 yr) completed two 4-min treadmill running bouts (2 min at 12 and 15 km·h-1) under two conditions: a no-compression control (CON1) and compression (COMP). For study 2, 14 participants (77.8 ± 8.4 kg, 27 ± 5 yr) completed four 9-min treadmill running bouts (3 min at 8, …


The Potential Of Ultraviolet Radiation Meters In Secondary Schools As A Sun Protection Intervention Mechanism For Adolescents, Simone Pettigrew, Ashleigh Parnell, Mark Strickland, Rachel Neale, Robyn Lucas Jan 2020

The Potential Of Ultraviolet Radiation Meters In Secondary Schools As A Sun Protection Intervention Mechanism For Adolescents, Simone Pettigrew, Ashleigh Parnell, Mark Strickland, Rachel Neale, Robyn Lucas

Research outputs 2014 to 2021

The aim of this pilot study was to assess whether the installation of ultraviolet radiation (UVR) meters in secondary schools has the potential to improve adolescents’ sun protection‐related knowledge, attitudes, and behaviours and reduce their exposure to UVR during school hours. Data were collected from students at two schools via online pre‐ and post‐intervention surveys, measurement of sunscreen usage, polysulfone UVR exposure badges, and photographs of the schoolyards to assess hat and shade use. Several operational issues limited the quantity and quality of data that could be collected, and findings were mixed. While there were no significant changes in either …


Geographical Disparities In Screening And Cancer- Related Health Behaviour, Belinda Goodwin, Arlen K. Rowe, Fiona Crawford-Williams, Peter Baade, Suzanne K. Chambers, Nicholas Ralph, Joanne F. Aitken Jan 2020

Geographical Disparities In Screening And Cancer- Related Health Behaviour, Belinda Goodwin, Arlen K. Rowe, Fiona Crawford-Williams, Peter Baade, Suzanne K. Chambers, Nicholas Ralph, Joanne F. Aitken

Research outputs 2014 to 2021

This study aimed to identify whether cancer-related health behaviours including participation in cancer screening vary by geographic location in Australia. Data were obtained from the 2014–2015 Australian National Health Survey, a computer-assisted telephone interview that measured a range of health-related issues in a sample of randomly selected households. Chi-square tests and adjusted odds ratios from logistic regression models were computed to assess the association between residential location and cancer-related health behaviours including cancer screening participation, alcohol consumption, smoking, exercise, and fruit and vegetable intake, controlling for age, socio-economic status (SES), education, and place of birth. The findings show insufficient exercise, …


Prkag2 Gene Expression Is Elevated And Its Protein Levels Are Associated With Increased Amyloid-Β Accumulation In The Alzheimer’S Disease Brain, Prashant Bharadwaj, Ralph Martins Jan 2020

Prkag2 Gene Expression Is Elevated And Its Protein Levels Are Associated With Increased Amyloid-Β Accumulation In The Alzheimer’S Disease Brain, Prashant Bharadwaj, Ralph Martins

Research outputs 2014 to 2021

Increased amyloid-β (Aβ) accumulation associated with abnormal autophagy-lysosomal activity and nutrient kinase dysregulation are common features in Alzheimer’s disease (AD) brain. Recent studies have identified PRKAG2 and TIPRL genes that control nutrient kinase regulated autophagy, and here we determined if their expression is altered in postmortem AD brains. Gene and protein expression of TIPRL were unchanged. However, gene expression of PRKAG2 was increased 3-fold and its protein levels positively correlated with Aβ accumulation in the AD brain. In summary, our findings suggest that increased PRKAG2 is an important contributing factor to Aβ accumulation in the AD brain.


Increasing Food Expenditure In Long Daycare By An Extra $0.50 Per Child/Day Would Improve Core Food Group Provision, Ros Sambell, Ruth Wallace, Johnny Lo, Leesa Costello, Amanda Devine Jan 2020

Increasing Food Expenditure In Long Daycare By An Extra $0.50 Per Child/Day Would Improve Core Food Group Provision, Ros Sambell, Ruth Wallace, Johnny Lo, Leesa Costello, Amanda Devine

Research outputs 2014 to 2021

Early childhood education and care services are a significant feature of Australian family life, where nearly 1.4 million children attended a service in 2019. This paper reports on the cost of food provided to children in long day-care (LDC) services and extrapolates expenditure recommendations to support food provision compliance. A cross-sectional audit of LDC services in metropolitan Perth was conducted to determine food group provision by weighing raw ingredients of meal preparation—morning tea, lunch, and afternoon tea (MT, L, AT). Ingredients were costed at 2017 online metropolitan pricing from a large supermarket chain. Across participating services, 2 days of food …


Sex And Apoe Ε4 Genotype Modify The Alzheimer’S Disease Serum Metabolome, Matthias Arnold, Kwangsik Nho, Alexandra Kueider-Paisley, Tyler Massaro, Kevin Huynh, Barbara Brauner, Siamak Mahmoudian Dehkordi, Gregory Louie, M. Arthur Moseley, J. Will Thompson, Lisa St John-Williams, Jessica D. Tenenbaum, Colette Colette, Rui Chang, Roberta D. Brinton, Rebecca Baillie, Xianlin Han, John Q. Trojanowski, Leslie M. Shaw, Ralph Martins, Michael W. Weiner, Eugenia Trushina, Jon B. Toledo, Peter J. Meikle, David A. Bennett, Jan Krumsiek, P. Murali Doraiswamy, Andrew J. Saykin, Rima Kaddurah-Daouk, Gabi Kastenmuller Jan 2020

Sex And Apoe Ε4 Genotype Modify The Alzheimer’S Disease Serum Metabolome, Matthias Arnold, Kwangsik Nho, Alexandra Kueider-Paisley, Tyler Massaro, Kevin Huynh, Barbara Brauner, Siamak Mahmoudian Dehkordi, Gregory Louie, M. Arthur Moseley, J. Will Thompson, Lisa St John-Williams, Jessica D. Tenenbaum, Colette Colette, Rui Chang, Roberta D. Brinton, Rebecca Baillie, Xianlin Han, John Q. Trojanowski, Leslie M. Shaw, Ralph Martins, Michael W. Weiner, Eugenia Trushina, Jon B. Toledo, Peter J. Meikle, David A. Bennett, Jan Krumsiek, P. Murali Doraiswamy, Andrew J. Saykin, Rima Kaddurah-Daouk, Gabi Kastenmuller

Research outputs 2014 to 2021

Late-onset Alzheimer’s disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give rise to large metabolic differences. We systematically investigated group-specific metabolic alterations by conducting stratified association analyses of 139 serum metabolites in 1,517 individuals from the AD Neuroimaging Initiative with AD biomarkers. We observed substantial sex differences in effects of 15 metabolites with partially overlapping differences for APOE ε4 status groups. Several group-specific metabolic alterations were not observed in unstratified analyses using sex and APOE ε4 as covariates. Combined stratification revealed further …


Clarifying Workforce Flexibility From A Division Of Labor Perspective: A Mixed Methods Study Of An Emergency Department Team, Sarah Wise, Christine Duffield, Margaret Fry, Michael Roche Jan 2020

Clarifying Workforce Flexibility From A Division Of Labor Perspective: A Mixed Methods Study Of An Emergency Department Team, Sarah Wise, Christine Duffield, Margaret Fry, Michael Roche

Research outputs 2014 to 2021

Background: The need for greater flexibility is often used to justify reforms that redistribute tasks through the workforce. However, "flexibility" is never defined or empirically examined. This study explores the nature of flexibility in a team of emergency doctors, nurse practitioners (NPs), and registered nurses (RNs), with the aim of clarifying the concept of workforce flexibility. Taking a holistic perspective on the team's division of labor, it measures task distribution to establish the extent of multiskilling and role overlap, and explores the behaviors and organizational conditions that drive flexibly.

Methods: The explanatory sequential mixed methods study was set in the …


International Olympic Committee Consensus Statement: Methods For Recording And Reporting Of Epidemiological Data On Injury And Illness In Sport 2020 (Including Strobe Extension For Sport Injury And Illness Surveillance (Strobe-Siis)), Roald Bahr, Ben Clarsen, Wayne Derman, Jiri Dvorak, Carolyn Emery, Caroline Finch, Martin Hägglund, Astrid Junge, Simon Kemp, Karim M. Khan, Stephen W. Marshall, Willem Meeuwisse, Margo Mountjoy, John W. Orchard, Babette Pluim, Kenneth L. Quarrie, Bruce Reider, Martin Schwellnus, Torbjorn Soligard, Keith A. Stokes, Taoomas Timpka, Evert Verhagen, Abhinav Bindra, Rcihard Budgett, Lars Engebretsen, Ugur Erdener, Karim Charmari Jan 2020

International Olympic Committee Consensus Statement: Methods For Recording And Reporting Of Epidemiological Data On Injury And Illness In Sport 2020 (Including Strobe Extension For Sport Injury And Illness Surveillance (Strobe-Siis)), Roald Bahr, Ben Clarsen, Wayne Derman, Jiri Dvorak, Carolyn Emery, Caroline Finch, Martin Hägglund, Astrid Junge, Simon Kemp, Karim M. Khan, Stephen W. Marshall, Willem Meeuwisse, Margo Mountjoy, John W. Orchard, Babette Pluim, Kenneth L. Quarrie, Bruce Reider, Martin Schwellnus, Torbjorn Soligard, Keith A. Stokes, Taoomas Timpka, Evert Verhagen, Abhinav Bindra, Rcihard Budgett, Lars Engebretsen, Ugur Erdener, Karim Charmari

Research outputs 2014 to 2021

Injury and illness surveillance, and epidemiological studies, are fundamental elements of concerted efforts to protect the health of the athlete. To encourage consistency in the definitions and methodology used, and to enable data across studies to be compared, research groups have published 11 sport-specific or setting-specific consensus statements on sports injury (and, eventually, illness) epidemiology to date. Our objective was to further strengthen consistency in data collection, injury definitions and research reporting through an updated set of recommendations for sports injury and illness studies, including a new Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist extension. The IOC …


Association Between The Triglyceride To High-Density Lipoprotein Cholesterol Ratio And The Risk Of Type 2 Diabetes Mellitus Among Chinese Elderly: The Beijing Longitudinal Study Of Aging, Dequiang Zheng, Haibin Li, Feiling Ai, Fei Sun, Manjot Singh, Xue Cao, Jiajia Jiang, Yan He, Zhe Tang, Xiuhua Guo Jan 2020

Association Between The Triglyceride To High-Density Lipoprotein Cholesterol Ratio And The Risk Of Type 2 Diabetes Mellitus Among Chinese Elderly: The Beijing Longitudinal Study Of Aging, Dequiang Zheng, Haibin Li, Feiling Ai, Fei Sun, Manjot Singh, Xue Cao, Jiajia Jiang, Yan He, Zhe Tang, Xiuhua Guo

Research outputs 2014 to 2021

Objective: Time-dependent covariates are generally available as longitudinal data were collected periodically in the cohort study. To examine whether time-dependent triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio could predict the future risk of type 2 diabetes mellitus (T2DM) and assess its potential impact on the risk of T2DM incidence. Research design and methods: This study enrolled 1460 participants without T2DM aged 55 or above in 1992 in the Beijing Longitudinal Study of Aging during 25 years. The questionnaire data were collected in nine surveys from 1992 to 2017. Physical examination and blood laboratory tests including TG and HDL-C concentrations were …


A Sensorimotor Control Framework For Understanding Emotional Communication And Regulation, Justin H.G. Williams, Charlotte F. Huggins, Barbra Zupan, Megan Willis, Tamsyn E. Van Rheenen, Wataru Sato, Romina Palermo, Catherine Ortner, Martin Krippl, Mariska Kret, Joanne M. Dickson, Chiang-Shan R. Li, Leroy Lowe Jan 2020

A Sensorimotor Control Framework For Understanding Emotional Communication And Regulation, Justin H.G. Williams, Charlotte F. Huggins, Barbra Zupan, Megan Willis, Tamsyn E. Van Rheenen, Wataru Sato, Romina Palermo, Catherine Ortner, Martin Krippl, Mariska Kret, Joanne M. Dickson, Chiang-Shan R. Li, Leroy Lowe

Research outputs 2014 to 2021

Our research team was asked to consider the relationship of the neuroscience of sensorimotor control to the language of emotions and feelings. Actions are the principal means for the communication of emotions and feelings in both humans and other animals, and the allostatic mechanisms controlling action also apply to the regulation of emotional states by the self and others. We consider how motor control of hierarchically organised, feedback-based, goal-directed action has evolved in humans, within a context of consciousness, appraisal and cultural learning, to serve emotions and feelings. In our linguistic analysis, we found that many emotion and feelings words …


Medical-Attention Injuries In Community Cricket: A Systematic Review, Geordie Mcleod, Siobhan O'Connor, Damian Morgan, Alex Kountouris, Caroline F. Finch, Lauren V. Fortington Jan 2020

Medical-Attention Injuries In Community Cricket: A Systematic Review, Geordie Mcleod, Siobhan O'Connor, Damian Morgan, Alex Kountouris, Caroline F. Finch, Lauren V. Fortington

Research outputs 2014 to 2021

Objectives: The aim was to identify and describe outcomes from original published studies that present the number, nature, mechanism and severity of medically treated injuries sustained in community-level cricket. Design: Systematic review. Methods: Nine databases were systematically searched to December 2019 using terms "cricket∗" and "injur∗". Original, peer-reviewed studies reporting injury for at least one injury descriptor (body region, nature of injury and/or mechanism of injury) in community-level cricketers of all ages were included. Qualitative synthesis, critical appraisal and descriptive summary results are reported within the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Results: Six studies were …


Recent High School Graduates Support Mandatory Cardiopulmonary Resuscitation Education In Australian High Schools, Tim Rankin, Lisa Holmes, Leanne Vance, Tom Crehan, Brennen Mills Jan 2020

Recent High School Graduates Support Mandatory Cardiopulmonary Resuscitation Education In Australian High Schools, Tim Rankin, Lisa Holmes, Leanne Vance, Tom Crehan, Brennen Mills

Research outputs 2014 to 2021

Objective:

To evaluate recent high school graduates' opinions on mandatory cardiopulmonary resuscitation (CPR) training in the high school curriculum as a solution to improving bystander CPR rates.

Methods:

Participants completed questionnaires assessing their CPR training history during their high school education, their willingness to learn CPR during their high school years and their opinion on making CPR training mandatory for high school curricula.

Results:

Of the 178 participants in this study, 60% had undertaken CPR training during their high school education. Of those who had not undertaken CPR training, 75% reported that they would have been willing …


Should The Pbl Tutor Be Present? A Cross-Sectional Study Of Group Effectiveness In Synchronous And Asynchronous Settings, Samuel Edelbring, Siw Alehagen, Evalotte Mörelius, Annakarin Johansson, Patrik Rytterström Jan 2020

Should The Pbl Tutor Be Present? A Cross-Sectional Study Of Group Effectiveness In Synchronous And Asynchronous Settings, Samuel Edelbring, Siw Alehagen, Evalotte Mörelius, Annakarin Johansson, Patrik Rytterström

Research outputs 2014 to 2021

Background: The tutorial group and its dynamics are a cornerstone of problem-based learning (PBL). The tutor's support varies according to the setting, and it is pertinent to explore group effectiveness in relation to different settings, for example online or campus-based. The PBL groups' effectiveness can partly be assessed in terms of cognitive and motivational aspects, using a self-report tool to measure PBL group effectiveness, the Tutorial Group Effectiveness Instrument (TGEI). This study's aim was to explore tutor participation in variations of online and campus-based tutorial groups in relation to group effectiveness. A secondary aim was to validate a tool for …


Anterior Cruciate Ligament Injuries In Australian Football: Should Women And Girls Be Playing? You're Asking The Wrong Question, Aaron Fox, Jason Bonacci, Samantha Hoffmann, Sophia Nimphius, Natalie Saunders Jan 2020

Anterior Cruciate Ligament Injuries In Australian Football: Should Women And Girls Be Playing? You're Asking The Wrong Question, Aaron Fox, Jason Bonacci, Samantha Hoffmann, Sophia Nimphius, Natalie Saunders

Research outputs 2014 to 2021

Anterior cruciate ligament (ACL) injuries have been a rising concern in the early years of the women's Australian Football League (AFLW), eliciting headlines of a â € knee crisis' surrounding the league. There has been a focus on female biology as the primary factor driving the high rate of ACL injuries in the AFLW. Emphasising Australian football (AF) as being dangerous predominantly due to female biology may be misrepresenting a root cause of the ACL injury problem, perpetuating gender stereotypes that can restrict physical development and participation of women and girls in the sport. We propose that an approach addressing …


Document Analysis Of Exertional Heat Illness Policies And Guidelines Published By Sports Organisations In Victoria, Australia, Prasanna J. Gamage, Caroline F. Finch, Lauren V. Fortington Jan 2020

Document Analysis Of Exertional Heat Illness Policies And Guidelines Published By Sports Organisations In Victoria, Australia, Prasanna J. Gamage, Caroline F. Finch, Lauren V. Fortington

Research outputs 2014 to 2021

Objectives To conduct a document and content analysis of exertional heat illness (EHI)-related documents published by sports organisations in Victoria, Australia, in order to determine their scope and evidence base against current international best practice recommendations. Methods A qualitative document and content analysis. Official documents relating to EHI were identified through a search of 22 Victorian sport organisation websites, supplemented by a general internet search. The content of these documents was evaluated against recommendations presented in three current international position statements on prevention and management of EHI. Results A range of document types addressing EHI were identified (n= 25), including …