Medicine and Health Sciences Commons^™

Noninvasive Monitoring Of Central Venous Oxygen Saturation By Jugular Transcutaneous Near-Infrared Spectroscopy In Pediatric Patients Undergoing Congenital Cardiac Surgery, Di̇lek Altun, Abdullah Doğan, Ahmet Arnaz, Adnan Yüksek, Yusuf Kenan Yalçinbaş, Riza Türköz, Cafer Tayyar Sarioğlu

Turkish Journal of Medical Sciences

Background and aim: In patients undergoing congenital cardiac surgery, it is crucial to maintain oxygen demand-consumption balance. Central venous oxygen saturation (ScvO2) is a useful indicator of oxygen demand and consumption balance which is an invasive method. Near-infrared spectroscopy (NIRS) is a noninvasive, continuous monitoring technique that measures regional tissue oxygenation. NIRS that is placed over the internal jugular vein cutaneous area (NIRSijv) has the potential to show ScvO2 indirectly. In this study, we aimed to determine the correlation between ScvO2 with NIRSijv in pediatric patients undergoing congenital cardiac surgery.Materials and methods: Fifty children participated in the study. Four patients …

Baseline Characteristics Predicting Clinical Outcomes And Serious Adverse Events In Middle-Aged Hypertensive Women: A Subanalysis Of The Sprint In Women Aged, Volkan Aydin, Ahmet Akici, Si̇bel Sakarya, Mehmet Akman, Ali̇ Serdar Fak

Turkish Journal of Medical Sciences

Background/aim: The predictability of clinical outcomes in hypertension in specific patient groups, especially underrepresented populations is the key to rational treatment. This study aimed to investigate the impact of baseline characteristics of

Association Between Monocyte To High-Density Lipoprotein Cholesterol Ratio And Bicuspid Aortic Valve Degeneration, Bi̇lge Duran Karaduman, Hüseyi̇n Ayhan, Telat Keleş, Engi̇n Bozkurt

Turkish Journal of Medical Sciences

Background/aim: From a pathophysiological point of view, inflammation is thought to be more dominant in bicuspid aortic valve (BAV) stenosis than tricuspid aortic valve (TAV) stenosis. Our study aimed to determine the association between monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR), a new inflammatory marker, and the speed of progression of stenosis and pathophysiology of BAV stenosis.Materials and methods: A total of 210 severe aortic stenosis patients (70 consecutive BAV patients, 140 matched TAV patients) were retrospectively enrolled in the study. Clinical and echocardiographic data and laboratory results related to our research were collected retrospectively from the patients' records. …

Determination Of Related Factors About Diagnostic And Treatment Delays In Patients With Smear-Positive Pulmonary Tuberculosis In Turkey, Mustafa Hami̇dullah Türkkani, Tarkan Özdemi̇r, Çi̇ğdem Özdi̇lekcan

Turkish Journal of Medical Sciences

Background/aim: This study aimed to analyze delays in diagnosis and treatment by defining the related demographic and clinical factors, to reveal obstacles, and to develop essential attempts to help reduce treatment delays.Materials and methods: We created a questionnaire on the subject of delays in diagnosis and treatment in tuberculosis (TB) control to be administered to the patients. The forms were distributed to dispensaries across the country by the General Directorate of Public Health via an official letter. Results: The study included 853 new patients with smear-positive pulmonary TB. The mean patient delay was 18.06 ± 22.27 days, the mean diagnosis …

Coenzyme Q10, Zinc And Mda Levels In Verruca Vulgaris, Selma Korkmaz, Fevzi̇ye Burcu Şi̇ri̇n, İjlal Erturan, Hali̇l İbrahi̇m Büyükbayram, Mehmet Yildirim

Turkish Journal of Medical Sciences

Background/aim: Verruca vulgaris is a benign disease characterized with papillomas on the skin and mucosa. The aim of this study was to investigate the serum levels of coenzyme Q10, MDA, and zinc as well as the lipid profile of verruca vulgaris patients and examine the relationship between these parameters and clinical manifestations of the disease.Materials and methods: The study included 49 verruca vulgaris patients (mean age: 32.01 ± 14.20 years; 22 males, 27 females) and 40 healthy volunteers (mean age: 31.63 ± 8.98 years; 21 males and 19 females). Coenzyme Q10 levels were assessed by using an enzyme-linked immunosorbent assay. …

Histopathological And Mechanical Effects Of Ankaferd Blood Stopper® On Wound Healing In Rats: An Experimental Model, Sertaç Hancioğlu, Berat Di̇lek Demi̇rel, Ünal Biçakci, Seda Gün, Mehmet Ender Aritürk, Nurşen Aritürk

Turkish Journal of Medical Sciences

Background/aim: To evaluate the histopathological and mechanical effects of Ankaferd Blood Stopper (ABS) application on wound healing.Materials and methods: A total of 24 Wistar albino rats were randomly divided into three equal groups. In each group, a 3 cm-long midline vertical skin incision was performed in the back of the rats. In Group 1, the incision was sutured primarily. In Group 2, incision was left to secondary healing. In Group 3, ABS was applied to the incision. On the 10th day, burst pressure width was measured, and rats were sacrificed. The tissue samples were examined histopathologically. Statistical analysis was conducted …

Do Different Surgical Techniques In Tibia Pilon Fractures Change The Results Of The Midterm?, Vedat Bi̇çi̇ci̇, İzzet Bi̇ngöl

Turkish Journal of Medical Sciences

Background/aim: Pilon fracture is difficult to treat fractures due to many complications that can develop after surgery. To achieve the best results, different surgical approaches are used.In our study, we aimed to compare the functional results and complication rates of our treatments in patients treated with 3 different surgical tecniques. Materials and methods: 89 pilon fractures of 87 patients treated for pilon fracture were evaluated. Patients were examined in 3 different groups (one step, two step surgery and Ilizarov). Functional results, postoperative complications and ankle AOFAS scores were evaluated. Results: The mean AOFAS score of the all patients was 77.67. …

Covid-19 And Dermatology, Ülker Gül

Turkish Journal of Medical Sciences

Background/aim: Sars-CoV-2 virus infection (COVID-19) was observed in China in the last months of 2019. In the period following, this infection spread all over the world. In March 2020 the World Health Organization announced the existence of a pandemic. The aim of this manuscript is to investigate skin diseases associated with COVID-19 under three main headings: skin problems related to personal protective equipment and personal hygiene measures, skin findings observed in SARS-CoV-2 virus infections, and skin findings due to COVID-19 treatment agents. Materials and methods: In PubMed, Google Scholar databases, skin lesions related to personal protective equipment and personal hygiene …

Silent Cerebral Infarct In Sickle Cell Anemia Patients Of Southern Turkey, Ezgi̇ Nafi̇le Sayman, Göksel Leblebi̇satan, Şeri̇fe Leblebi̇satan, Yunus Kenan Biçakci, Yurdanur Kilinç, Adnan Barutçu

Turkish Journal of Medical Sciences

Background/aim: Silent cerebral infarct (SCI) is an ischemic lesion seen before clinical signs of brain infarct and ischemic changes in brain tissue. This study aimed to detect SCI with noninvasive methods and to determine related risk factors in patients with sickle cell anemia (SCA). Materials and methods: Fifty-four SCA patients who had no history of cerebral infarct and whose neurological examinations were normal were included in this study. Brain magnetic resonance imaging (MRI) and diffusion MRI were taken and the acquired data was compared statistically. Results: SCI was detected in 11.1% (6/54) of the patients. No statistical differences in age, …

Cross-Sectional Study: Long Term Follow-Up Care For Pediatric Cancer Survivors In Adeveloping Country, Turkey: Current Status, Challenges, And Future Perspectives, Sonay İncesoy Özdemi̇r, Nurdan Taçyildiz, Ali̇ Varan, Reji̇n Kebudi̇, Osman Bülent Zülfi̇kar, Tüli̇n Tiraje Celkan, Gürses Şahi̇n, Funda Vesi̇le Çorapcioğlu, Zuhal Keski̇n Yildirim, Faruk Güçlü Pinarli, Hati̇ce Nur Olgun, Neriman Sari, Ayhan Dağdemi̇r, Derya Özyörük, Tuba Eren

Turkish Journal of Medical Sciences

Aim: The main purpose of this study is to determine the current status of long-term follow-up (LTFU) for childhood cancer survivors and the challenges of LTFU for pediatric cancer survivors at pediatric oncology institutions in Turkey. Material and methods: A questionnaire was e-mailed to the directors of 33 pediatric oncology centers (POCs) registered in the Turkish Pediatric Oncology Group (TPOG). Of these 33 active TPOG institutions, 21 participated in the study and returned their completed questionnaires. Results: Only 1 of the 21 participating centers had a separate LTFU clinic. The remaining centers provided LTFU care for childhood cancer survivors at …

Clinical And Demographic Characteristics Of Children And Adolescents With Acute Vertigosymptoms: A Cross-Sectional Study, Arzu Yilmaz, Sema Ni̇lay Abseyi̇

Turkish Journal of Medical Sciences

Background/aim: Vertigo is one of the rarely diagnosed disorders during childhood due to insufficient description of the children regarding their experiences to the physicians. The clinical features of children and adolescents admitted by acute vertigo symptoms were investigated to elaborate the subject retrospectively. Materials and methods: Between January 2017-July 2019, records of cases admitted with acute vertigo complaints to pediatric neurology were retrospectively examined. Results: Of 761 patients, mean age was 13.8 years, 64% (n = 487) were women, 22.6% (n = 172) of which were children (1-11 years). A total of 37.3% of the cases (n = 284) had …

Proteomic Analysis Of The Anticancer Effect Of Various Extracts Of Endemicthermopsis Turcica In Human Cervical Cancer Cells, Mustafa Yildiz, Hakan Terzi̇, Sali̇ha Handan Yildiz, Nuray Varol, Müjgan Özdemi̇r Erdoğan, Murat Kasap, Nermi̇n Akçali, Mustafa Solak

Turkish Journal of Medical Sciences

Background/aim: Thermopsis turcica is a perennial species endemic to Turkey and different extracts of T. turcica have an antiproliferative effect on cancer cells, but there has not been any report on HeLa (human cervical cancer) cells. Materials and methods: To get a better understanding of the molecular mechanism of anticancer activity of methanolic extracts of leaves (LE) and flowers (FE) of T. turcica, we employed 2-DE-based proteomics to explore the proteins involved in anticancer activity in HeLa cells. Results: T. turcica extracts showed a potent cytotoxic effect on HeLa cells with the IC50 values of 1.75 mg/mL for LE and …

Covid-19 Outbreak Control, Example Of Ministry Of Health Of Turkey, Yasemi̇n Demi̇rbi̇lek, Gülen Pehli̇vantürk, Zeynep Özge Özgüler, Emi̇ne Alp Meşe

Turkish Journal of Medical Sciences

Our first COVID-19 case in Turkey was a 44-year-old male who referred to the hospital on March 9, 2020. The first related death occurred on March 17, 2020. Preparedness for the pandemic has been ongoing before the first case was detected. The National Pandemic Plan was published in 2006. The Pandemic Influenza National Preparedness Plan was available after being updated in light of experiences gained during the 2009 Influenza A pandemic. Accordingly, Pandemic Coordination Boards and Operation Centers have been established on the national and provincial levels. This was an adaptable plan to the Novel Coronavirus Disease (COVID-19). We formed …

Quarantine And Its Legal Dimension, Rahmi̇ Kiliç, Çi̇ğdem Ataman Hati̇poğlu, Cemi̇l Güneş

Turkish Journal of Medical Sciences

Quarantine and isolation are public health measures used for centuries to prevent the spread of infectious diseases. Quarantine is separation of persons who have been exposed to an infection but asymptomatic, while isolation is separation of infected patients. Voluntary quarantine is preferred, but if necessary, it can be mandatory. These implementations can lead to restrictions on individual liberties, leading to ethical and legal problems. Isolation and quarantine enforcement are regulated by laws. Those who do not follow the quarantine rules could be punished. Isolation and quarantine practices in our country are described in General Hygiene Law. In this study the …

Covid-19: Prevention And Control Measures In Community, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Fi̇rdevs Aktaş

Turkish Journal of Medical Sciences

On January 30, 2020, the WHO declared the COVID-19 outbreak a public health emergency of international concern and, in March 2020, began to characterize it as a pandemic in order to emphasize the gravity of the situation and urge all countries to take action in detecting infection and preventing spread. Unfortunately, there is no medication that has been approved by the FDA, gone through controlled studies and demonstrated an effect on the virus for this global pandemic. Although there are cures for illnesses and developments made by leaps and bounds in our day, the strongest and most effective weapon that …

Covid-19: Pathogenesis, Genetic Polymorphism, Clinical Features And Laboratory Findings, Recep Öztürk

Turkish Journal of Medical Sciences

COVID-19 caused by a novel agent SARS-CoV-2 progressed to a pandemic condition and resulted in a major public health concern worldwide, leading to social and economic issues at the same time. The pathogenesis of COVID-19 starts with the bonding of the virus to ACE2 receptors expressed in many tissues, and the triggered excessive immune response plays a critical role in the course of the disease. The cytokine storm that occurs upon excessive production of pro-inflammatory cytokines is considered responsible for the severe progression of the disease and the organ damage. However, the accurate pathophysiological mechanism of the disease, which progresses …

Igg4-Related Disease: A Contemporary Review, Hazan Karadeni̇z, Augusto Vaglio

Turkish Journal of Medical Sciences

Background/aim: Immunoglobulin G4-related disease (IgG4-RD), is an immune-mediated fibroinflammatory condition, which may involve multiple organs and mostly presents with high serum IgG4 levels and specific histopathological characteristics. As IgG4-RD is a relatively new entity the etiology, prevalence and epidemiologic knowledge is quite limited. Although involvement of almost all anatomical regions has been reported, the most commonly affected regions are pancreas, lacrimal glands, salivary glands, retroperitoneum, orbita, lymph nodes, kidney and lungs. Diagnosis is made with combined evaluation of clinical, radiological and histopathological findings. Typical histopathological features include storiform fibrosis, dense lymphoplasmacytic infiltrates and obliterative phlebitis. Its course is typically marked …

Graft-Versus-Cancereffect And Innovative Approaches In Thetreatment Of Refractorysolid Tumors, Uğur Şahi̇n, Taner Demi̇rer

Turkish Journal of Medical Sciences

Background/aim: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been used for the treatment of various refractory solid tumors during the last two decades. After the demonstration of graft-versus-leukemia (GvL) effect in a leukemic murine model following allo-HSCT from other strains of mice, graft-versus-tumor (GvT) effect in a solid tumor after allo-HSCT has also been reported in a murine model in 1984. Several trials have reported the presence of a GvT effect in patients with various refractory solid tumors, including renal, ovarian and colon cancers, as well as soft tissue sarcomas [1]. The growing data on haploidentical transplants also indicate GvT …

New Author Guidelines In Statistical Reporting: Embracing An Era Beyond P < .05, Samantha Johnson, Whitley J. Stone, Jennifer Bunn, Scott Lyons, James W. Navalta

Kinesiology and Nutrition Sciences Faculty Research

Statistical reporting of quantitative research data has been plagued by potential bias and reporting suppression due to a single numerical output: the p-value. While there is great importance in its merit, creating a pass-fail system (set at point of .05) has created a culture of researchers submitting their project’s data to a filing cabinet if it does not yield “statistical significance” based on this value. The editors of the International Journal of Exercise Science are following the American Statistical Association’s call for statistical reform by adjusting our reporting guidelines to the following requirements: [1.] make an intentional effort to move …

“It’S Not A Luxury, It’S A Need:” Exploring The Extra Costs Of Vision Loss, Katie Savin

All Faculty Scholarship

No abstract provided.

Review Of The Scientific Literature On Young Adults Related To Cardiovascular Disease Intervention, Dieu-My T. Tran, Angela Sojobi

Nursing Faculty Research

Many young adults are at risk for cardiovascular disease related to their behavioral choices. Irresponsible alcohol consumption, tobacco smoking, sedentary lifestyle, poor dietary habits, and excessive weight gain are some of the behaviors that put young adults at risk. The Centers for Disease Control and Prevention identified that 15% of young adults are diagnosed with chronic illnesses related to their behavioral choices. The purpose of this review is to identify, in the literature, interventions that are currently available to young adults and evaluate the adequacy and effectiveness of those interventions. An extensive electronic search was conducted using CINAHL, EBSCOhost, Cochrane, …

Exploring Factors Influencing Whether Residents Participate In Square Dancing Using Social Cognitive Theory: A Cross-Sectional Survey In Chongqing, China, Feng Peng, Hongjia Yan Bs, Manoj Sharma Phd, Ying Liu Bs, Ying Lu Bs, Shijie Zhu Bs, Peiqian Li Bs, Nianyong Ren Bs, Ting Li Bs, Yong Zhao Md

Environmental & Global Health Faculty Research

Physical inactivity is a worldwide public health problem, and it is a risk factor for several chronic diseases. Square dancing nightly may be an efficient way to promote physical activity among Chinese residents. This study aims to explore factors that affect resident participation in square dancing on the basis of social cognitive theory constructs (outcome expectations, outcome expectancies, self-efficacy, self-control, and environment) that may provide a scientific basis for designing interventions to promote physical activity in the future. Forty squares near neighborhood communities in Chongqing were randomly selected. A sample of 1732 residents who came to these squares at 18:00–21:00 …

Hippocampal Cholinergic Function And Exploratory Behavior Throughout Development In A Genetic Mouse Model Of Alzheimer’S Disease, Ashley Andrea Blackwell

Graduate Research Theses & Dissertations

Dementia of the Alzheimer’s type is the most common form of dementia, affecting millions of people worldwide. Specific genetic mutations increase Alzheimer’s disease-related neuropathology and cognitive impairments. Deficits are observed in spatial orientation throughout the progression of Alzheimer’s disease, including wandering behavior or becoming lost in a familiar environment. Dementia of the Alzheimer’s type patients also exhibit disruptions in radial optic flow, which underlies self-movement cue processing. Currently, no treatments exist for Alzheimer’s disease. Genetic mouse models of Alzheimer’s disease have been developed to investigate the disease onset and progression and, further, to evaluate potential therapies and behavioral assessments. As …

The Effect Of Music Attention Control Training (Mact) For Pre-Adolescents With Autism Spectrum Disorder, Vienna Sa

University of the Pacific Theses and Dissertations

The purposes of this study are to investigate the effect of the Music Attention Control Training (MACT) on three types of attention (sustained, selective, switching) in pre-adolescents (10-14 years old) with Autism Spectrum Disorder (ASD) and to identify the impact of the level of severity (mild, moderate, severe) on changes in attention scores. This modified replication study included 23 participants randomly assigned to treatment and control group stratified based on severity of ASD. Significant results via two-tailed paired-sample t-test (p< .10) indicated significant positive trends with the treatment group for the 3 out of 4 subtests of selective attention: Hector Cancellation, Hector-B Cancellation, and Hecuba Visual Search; 1 out of 4 subtests of sustained attention: Sustained Attention Response Test (SART); and the single subtest of switching attention: Red & Blues, Bags & Shoes (RBBS). Results call for modifications to further support the role of MACT on attention skills with pre-adolescents with ASD. Implications for future research and contributions to clinical practices in music therapy are discussed.

Exercise Training As Adjunct Therapy For Substance Use Disorder, Emily Lynn Roessel

University of the Pacific Theses and Dissertations

Exercise training for clients at out-patient drug rehabilitation centers likely helps with coping skills. However, a better examination of the mechanisms producing changes may help identify effective interventions. PURPOSE: To test the effect of a vigorous exercise prescription on drug abstinence in voluntary rehabilitation patients. METHODS: 25 surveyed participants in a male drug treatment program underwent a 12-week minimum training program. The program included moderate-rigorous exercise and psychotherapy. Three days per week all subjects participated in EP for 90 minutes. Subjects also participated in ABIT 3 days per week where each session lasted 2 hours. Subjects also participated in ESM …

Multicellular Spheroids Of A549 And A549-Irfp As An In Vitro Model Of Lung Cancer, Xinyu Pei

University of the Pacific Theses and Dissertations

Lung cancer is the second most common cancer in both men and women around the world, and 85% of it is non-small cell lung cancer (NSCLC). It is estimated that in 2020, there will be 228,820 cases of lung cancer and 135,720 deaths from lung (American Cancer Society, 2020). The prognosis of lung cancer is poor (

Traditionally, the most commonly used in vitro method for screening therapeutic drugs is monolayer cell cultures, which are reproducible, convenient and of low cost. However, monolayer cell culture models are unable to reproduce many properties of in vivo solid tumors such as the …

Insurance Status And Obesity As Predictors Of Cost In Trauma Care, Emily Homer

University of the Pacific Theses and Dissertations

Insurance is a vital factor in the billed cost to the patient, but to what degree does insurance explain the amount a patient is left to pay? Also, does obesity further influence patient’s billed cost? This thesis assesses the type of thoracic trauma patient, insurance status, and their billed cost. Database variables were analyzed in IBM SPSS 25. Table 1 characteristics were evaluated based on demographics and systematic hospital factors. Linear regressions used Private0_Government1 and BMI Obese n_y_ as independent variables while Total Patient Cost was the dependent variable. Private0_Government1 insurance explained .03% of Total Patient Charges. Private0_Government1 and BMI …

Health Care Professionals’ Compliance To Tracheal Suctioning Policy At A Tertiary Care Hospital, Rozina Khimani, Fauziya Ali, Salma Amin Rattani, Mohammad Sohail Awan

Department of Surgery Docs

Objective: To assess the compliance of tracheal suctioning practices against the standard guidelines of a tertiary care hospital, with regard to the participants’ professional characteristics.
Methods: Using cross sectional study design, forty health care professionals (HCPs) were assessed twice, using a quantitative structured observational design, for tracheal suctioning practices, in one of the surgical care units of the tertiary care hospital. Tracheal suctioning policy which was used as a tool, its inter-rater reliability was tested and each step showed the Kappa value of 0.65 to 1.000. Data was analyzed using epidata info version 3.5.1 and SPSS version 19.
Results: From …

Perceptions, Impact And Scope Of Medication Errors With Opioids In Australian Specialist Palliative Care Inpatient Services: A Mixed Methods Study (The Periscope Project), Nicole Heneka

Theses

Background: Opioids are a high-risk medicine, and one of the most frequently reported drug classes causing patient harm. In specialist palliative care inpatient services opioids are widely used to manage cancer pain and other symptoms. Palliative care inpatients are vulnerable to both exposure to, and harm from, opioid errors due to a combination of their: advanced age, comorbidities which affect drug metabolism, polypharmacy, and the seriousness of their illness. Despite this potential for harm, and the frequency of opioid administration in this specialist setting, little is known about opioid errors in palliative care. Better understanding the prevalence, patient impact and …

Safety And Effectiveness Of Stoss Therapy In Children With Vitamin D Deficiency, Paul Tannous

Theses

Objectives: Paediatric vitamin D (25-hydroxyvitamin D - 25OHD) deficiency can lead to nutritional rickets and extra-skeletal complications. Compliance with daily therapy can be difficult, making high dose, short-term vitamin D (stoss) therapy attractive to correct vitamin D deficiency. We compared the effectiveness and safety of standard versus stoss therapy in treating childhood 25OHD deficiency.

Study Design: Children aged 2 - 16 years with 25OHD <50nmol/L were randomized to either standard (5,000IU daily for 80 days) or stoss (100,000 IU weekly for 4 weeks) cholecalciferol. Participants underwent evaluation of effectiveness and safety. 25OHD, random spot calcium: creatinine ratio (Ca:Cr) and compliance were measured at 12 weeks.

Results: 151 children were enrolled in the study (68 standard and 83 stoss), median age 9 years (IQR: 6 - 12 years). Baseline 25OHD levels were 26 nmol/L (IQR: 19 - 35 nmol/L) and 32 nmol/L …