Medicine and Health Sciences Commons^™

2020-11-25_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

Expediting Rare Disease Diagnosis: A Call To Bridge The Gap Between Clinical And Functional Genomics., Samantha N. Hartin, John C. Means, Joseph Alaimo, Scott T. Younger

Manuscripts, Articles, Book Chapters and Other Papers

Approximately 400 million people throughout the world suffer from a rare disease. Although advances in whole exome and whole genome sequencing have greatly facilitated rare disease diagnosis, overall diagnostic rates remain below 50%. Furthermore, in cases where accurate diagnosis is achieved the process requires an average of 4.8 years. Reducing the time required for disease diagnosis is among the most critical needs of patients impacted by a rare disease. In this perspective we describe current challenges associated with rare disease diagnosis and discuss several cutting-edge functional genomic screening technologies that have the potential to rapidly accelerate the process of distinguishing …

Cognition In Health And Disease: Two Mouse Model Studies, Heather Lynn Mahoney

USF Tampa Graduate Theses and Dissertations

Cognitive and circadian dysfunction are common aspects of neuropsychiatric disease that are often overlooked in disease models and treatment strategies. In this work, we first evaluated the potential for cognitive enhancement in healthy adult mice by targeting a kinase involved in regulation of the molecular circadian clock. We then developed and characterized a model of neuropsychiatric disease that could present a target for rescuing circadian and cognitive deficits using this treatment.

Time-of-day effects have been noted in a wide variety of cognitive behavioral tests, and perturbation of circadian rhythms impairs hippocampus-dependent learning and memory. We first asked whether casein kinase …

Targeting Trimeric And Tetrameric Proanthocyanidins Of Cinnamomum Verum Bark As Bioactives For Dental Therapies, Joo-Won Nam, Rasika S. Phansalkar, David C. Lankin, James Mcalpine, Ariene A. Leme-Kraus, Ana K. Bedran-Russo, Shao-Nong Chen, Guido F. Pauli

School of Dentistry Faculty Research and Publications

The present study elucidated the structures of three A-type tri- and tetrameric proanthocyanidins (PACs) isolated from Cinnamomum verum bark to the level of absolute configuration and determined their dental bioactivity using two therapeutically relevant bioassays. After selecting a PAC oligomer fraction via a biologically diverse bioassay-guided process, in tandem with centrifugal partition chromatography, phytochemical studies led to the isolation of PAC oligomers that represent the main bioactive principles of C. verum: two A-type tetrameric PACs, epicatechin-(2β→O→7,4β→8)-epicatechin-(4β→6)-epicatechin-(2β→O→7,4β→8)-catechin (1) and parameritannin A1 (2), together with a trimer, cinnamtannin B1 (3). Structure …

Proanthocyanidin Block Arrays (Pacbar) For Comprehensive Capture And Delineation Of Proanthocyanidin Structures, Shuxi Jing, Wayne E. Zeller, Daneel Ferreira, Bin Zhou, Joo-Won Nam, Ana K. Bedran-Russo, Shao-Nong Chen, Guido F. Pauli

School of Dentistry Faculty Research and Publications

Proanthocyanidins (PACs) are near-ubiquitous and chemically complex metabolites, prototypical of higher plants. Their roles in food/feed/nutrition and ethnomedicine are widely recognized but poorly understood. With the analysis of evidence that underlies this challenge, this perspective identifies shortcomings in capturing and delineating PAC structures as key factors. While several groups have forwarded new representations, a consensus method that captures PAC structures concisely and offers high integrity for electronic storage is required to reduce confusion in this expansive field. The PAC block arrays (PACBAR) system fills this gap by providing precise and human- and machine-readable structural descriptors that capture PAC metabolomic structural …

Medication Use Among Older Australians Seeking Alcohol And Other Drug Treatment, Stephen Bright, John Milroy, Katherine Walsh, Emily Blatchford

Research outputs 2014 to 2021

Objective: To describe the use of medications that interact with alcohol or for which alcohol reduces the medication's efficacy in older adults consuming alcohol at hazardous levels.

Method: Retrospective file audit of patients discharged from Australia's only older adult-specific alcohol and other drug treatment service.

Results: Seventy-two patients aged between 58 years and 87 years (M = 65.88; SD = 5.67) drinking alcohol at hazardous or harmful levels were taking between 1 and 12 pharmaceutical drugs (M = 4.03; SD = 2.42). The majority (92%) of patients were taking at least one medication that placed them at high risk of …

Altered Capicua Expression Drives Regional Purkinje Neuron Vulnerability Through Ion Channel Gene Dysregulation In Spinocerebellar Ataxia Type 1, Ravi Chopra, David D Bushart, John P Cooper, Dhananjay Yellajoshyula, Logan M Morrison, Haoran Huang, Hillary P Handler, Luke J Man, Warunee Dansithong, Daniel R Scoles, Stefan M Pulst, Harry T Orr, Vikram G Shakkottai

2020-Current year OA Pubs

Selective neuronal vulnerability in neurodegenerative disease is poorly understood. Using the ATXN1[82Q] model of spinocerebellar ataxia type 1 (SCA1), we explored the hypothesis that regional differences in Purkinje neuron degeneration could provide novel insights into selective vulnerability. ATXN1[82Q] Purkinje neurons from the anterior cerebellum were found to degenerate earlier than those from the nodular zone, and this early degeneration was associated with selective dysregulation of ion channel transcripts and altered Purkinje neuron spiking. Efforts to understand the basis for selective dysregulation of channel transcripts revealed modestly increased expression of the ATXN1 co-repressor Capicua (Cic) in anterior cerebellar Purkinje neurons. Importantly, …

2020-11-24_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2020-11-24_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Coronavirus Update 11/24/20, The Coronavirus Planning Team

University Briefings & Virtual Events

One final message before the Thanksgiving weekend break to wrap up a few things.

2020-11-24_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

Utilization Of Asthma Guidelines In Primary Care, Kate R. Miller

Dissertations

Background: Chronic lower respiratory disease, including asthma, is the fourth leading cause of death in the U.S. Financially, asthma accounts for approximately 54 billion dollars in healthcare spending annually. The National Heart Lung and Blood Institute [NHLBI] established guidelines to reduce impairment and to reduce future asthma attacks.

Purpose: This Quality Improvement (QI) pilot implemented the Asthma Control Test (ACT) and the Asthma Action Plan (AAP) per NHLBI guidelines. This project aimed to increase provider use of the ACT and AAP to 50% in patients with a diagnosis of asthma over one month.

Methods: A convenience sample of six adult …

Hooked On A Feeling: Influence Of Brief Exposure To Familiar Music On Feelings Of Emotion In Individuals With Alzheimer's Disease, Alaine E. Reschke-Hernández, Amy M. Belfi, Edmarie Guzmán-Vélez, Daniel Tranel

Music Faculty Publications

BACKGROUND: Research has indicated that individuals with Alzheimer's-type dementia (AD) can experience prolonged emotions, even when they cannot recall the eliciting event. Less is known about whether music can modify the emotional state of individuals with AD and whether emotions evoked by music linger in the absence of a declarative memory for the eliciting event.

OBJECTIVE: We examined the effects of participant-selected recorded music on self-reported feelings of emotion in individuals with AD, and whether these feelings persisted irrespective of declarative memory for the emotion-inducing stimuli.

METHODS: Twenty participants with AD and 19 healthy comparisons (HCs) listened to two 4.5-minute …

2020-11-24_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Data About Places. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Use Of Fiberoptic Intubation Simulation To Enhance Skill And Confidence Among Anesthesia Providers, Kris Toribio

College of Science and Health Theses and Dissertations

Background The purpose of this study was to describe the usefulness of a video-recorded low-fidelity Fiber Optic (FO) intubation simulation and its effect on anesthesia providers’ confidence and skill in performing FO intubation. Method The study was conducted during the 2019 IANA Airway Workshop using a post-test only study design. All participants who volunteered to participate in the simulation were asked to watch a video-recorded instruction on FO intubation. Immediately after viewing the video, the participants completed a hands-on simulation while the researchers recorded their FO intubation times. Participants were allowed up to three recorded attempts. Results Fifty-eight participants completed …

Scales To Measure Motivation Among Community Health Workers, And Trust And Empowerment Among Their Clients: A Guide, Frontline Health Project

Reproductive Health

This How-To Guide presents five multi-item scales to measure motivation among community health workers (CHWs), as well as clients' trust in CHWs, and empowerment within community health systems. The scales presented are intended for use in community health programs and in combination with other indicators in the CHW Performance Measurement Framework (published by the Frontline Health project in 2019) for routine data monitoring to improve quality and accountability in community health.

Intraoperative Management Of Lumbar Cerebrospinal Fluid Drains: A Reference Tool, Victoria Shink

College of Science and Health Theses and Dissertations

Lumbar cerebrospinal fluid (CSF) drains are invasive interventional devices implemented for patients suffering from neurosurgical and complex aortic conditions. CSF drain management can be an infrequent task for anesthesia providers. Infrequent exposure can lead to inadvertent mismanagement leaving the patient vulnerable to increased morbidity and mortality. The purpose of this study was to develop a reference tool for basic intraoperative management of lumbar CSF drains and determine if CRNA and SRNA knowledge was improved with its use. This study utilized a pre-test/post-test design. The pre-test revealed significant knowledge gaps in content crucial for safe drain manipulation and management. Improvement in …

Childhood Maltreatment And Lead Levels In Middle Adulthood: A Prospective Examination Of The Roles Of Individual Socio-Economic And Neighborhood Characteristics, Anthony Carpi, Valentina Nikulina, Xuechen Li, Cathy Spatz Widom

Publications and Research

Background Lead is a common environmental hazard because of its past use as an additive to gasoline and household paint. Some evidence suggests that children with histories of child abuse and neglect are at elevated risk for residence in communities and households with less desirable characteristics and high levels of exposure to environmental hazards and toxins.

Objectives To understand whether childhood maltreatment leads to higher levels of household dust lead and blood lead in adulthood and the extent to which characteristics of a person’s physical environment or individual level socio-economic status (SES) (based on unemployment, poverty, and receipt of public …

Recording Of Endoscopy And Fluoroscopy Of The Vocal Tract With Sound (Or Its Absence): A Disappointment, Robert J Shprintzen, Pablo Antonio Ysunza

Articles

There is an old say: “The devil knows more for being old than for being the devil”. One of the advantages of being old and observing clinical practice and clinical research advance is that successful procedures and methods can be selected and put into practice. Indeed, it is possible to define when practices we thought could be used by our peers simply by being reported in the literature have proven to be doubtful hopes that leave us trying to find out what went wrong. Such is the case with imaging procedures of the vocal tract during speech tasks.

Exploring Quality Of Life Perceptions Among Pre-Clinical And Clinical Phases Saudi Medical Students, Olfat Gushgari

Seton Hall University Dissertations and Theses (ETDs)

Background: Medical students are widely recognized as a high-risk population for poor quality of life (QOL). Various studies have highlighted that medical students have a lower QOL than, compared to other students from different specialties tend to exhibit; specifically, the QOL of Saudi medical students is of growing concern, and it is imperative that Saudi medical schools recognize and address the QOL of these students.

Purpose: The purpose of this study was to explore the QOL of Saudi medical students during the pre-clinical and clinical phases of their studies. In addition, this study explored the QOL perceptions according …

Diagnosing And Managing Post-Stroke Aphasia, Shannon M. Sheppard, Rajani Sebastian

Communication Sciences and Disorders Faculty Articles and Research

Introduction: Aphasia is a debilitating language disorder and even mild forms of aphasia can negatively affect functional outcomes, mood, quality of life, social participation, and the ability to return to work. Language deficits after post-stroke aphasia are heterogeneous.

Areas covered: The first part of this manuscript reviews the traditional syndrome-based classification approach as well as recent advances in aphasia classification that incorporate automatic speech recognition for aphasia classification. The second part of this manuscript reviews the behavioral approaches to aphasia treatment and recent advances such as noninvasive brain stimulation techniques and pharmacotherapy options to augment the effectiveness of …

Validity And Reliability Of Physiological Data In Applied Settings Measured By Wearable Technology: A Rapid Systematic Review, Bryson Carrier, Brenna Barrios, Brayden D. Jolley, James W. Navalta

Kinesiology and Nutrition Sciences Faculty Research

The purpose of this review was to evaluate the current state of the literature and to identify the types of study designs, wearable devices, statistical tests, and exercise modes used in validation and reliability studies conducted in applied settings/outdoor environments. This was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We identified nine articles that fit our inclusion criteria, eight of which tested for validity and one tested for reliability. The studies tested 28 different devices with exercise modalities of running, walking, cycling, and hiking. While there were no universally common analytical techniques used …

Association Between Circulating Osteocalcin And Cardiometabolic Risk Factors Following A 4-Week Leafy Green Vitamin K-Rich Diet, Alexander Tacey, Marc Sim, Cassandra Smith, Mary N. Woessner, Elizabeth Byrnes, Joshua R. Lewis, Tara Brennan-Speranza, Jonathan M. Hodgson, Lauren C. Blekkenhorst, Itamar Levinger

Research outputs 2014 to 2021

Background: Evidence suggests that lower serum undercarboxylated osteocalcin (ucOC) may be negatively associated with cardiometabolic health. We investigated whether individuals with a suppression of ucOC following an increase in dietary vitamin K1 exhibit a relative worsening of cardiometabolic risk factors.

Materials and Methods: Men (n = 20) and women (n = 10) aged 62 ± 10 years participated in a randomized, controlled, crossover study. The primary analysis involved using data obtained from participants following a high vitamin K1 diet (HK; 4-week intervention of increased leafy green vegetable intake). High and low responders were defined based on the median percent reduction …

Outcome Analysis Of Tranexamic Acid In Thromboembolic Complications And Coagulation Factors, Hunter A. Mccorkle

University Honors Theses

Background: Tranexamic acid (TXA) is an antifibrinolytic used for controlling hemorrhaging in patients. It’s regular application in trauma centers could be vital in reducing all-cause mortality for hemorrhaging secondary to traumatic injury but there are still concerns about possible side effects and populations at greater risk of complications. The possible use of predictive measures such as thrombelastography (TEG) and conventional coagulation testing (CCT) in detecting early markers of TXA risks are still unconfirmed, and unfortunately there is a time restriction of 3 hours for TXA to be effective in reducing all-cause mortality.

Objective: Our objective is to observe outcomes of …

Innovation And New Technologies In Spine Surgery, Circa 2020: A Fifty-Year Review., G. Bryan Cornwall, Andrea Davis, William R. Walsh, Ralph J. Mobbs, Alexander Vaccaro

Rothman Institute Papers

Spine surgery (lumbar, cervical, deformity, and entire spine) has increased in volume and improved in outcomes over the past 50 years because of innovations in surgical techniques and introduction of new technologies to improve patient care. Innovation is described as a process to add value or create change in an enterprise's economic or social potential. This mini review will assess two of three assessments of innovation in spine surgery: scientific publications and patents issued. The review of both scientific publications and issued patents is a unique assessment. The third assessment of innovation: regulatory clearances of medical devices and equipment for …

Academic Leaders And The Regulatory Orientation: New And Improved!, Annmarie Munana

DNP Qualifying Manuscripts

The purpose of this article is to describe the challenges and regulatory knowledge gaps present in academic nursing leaders, explore orientation as an evidence-based approach to support leadership transition, recommend guiding frameworks, and report on the usefulness of orientations to facilitate academic regulatory compliance knowledge.

During this time of yet another nursing shortage, and considering the aging population and nursing workforce, professional organizations and nurse leaders strive to develop innovative solutions to attract individuals to nursing. The shortage is also present amongst the ranks of nursing faculty and academic nurse leaders and the profession needs strong leaders at the helm …

Forward Together Update [Covid-19 Response Team & Winter Break], November 23, 2020, University Of Northern Iowa

UNI Response to COVID-19

A memo from the COVID-19 Response Team reminding the UNI community to stay vigilant during the winter break and continue efforts to reduce the spread of COVID and that they will update information during the break. Also provides information on Student Health Clinic hours and useful links.

Age, Comorbidities, And Mortality Correlation In Covid-19 Patients: A Review, Vidyulata Salunkhe, Amr Aboelnasr, Parul Pahal, Nida Qadir, Simra Kiran, Balaji Sekaran, Omar Fahmy, Farah Daas, Syed Shah

The University of Louisville Journal of Respiratory Infections

Background: The risk of death due to COVID-19 among hospitalized patients is known to be higher in older adults and those with underlying health conditions. Understanding the proportion of patients who are at increased risk of death due to COVID-19 and how this varies between age groups will inform the healthcare community as to how to evaluate the risk of COVID-19 and better design healthcare and economic policies.

Methods: We conducted a literature search for studies published between December 2019 and May 16, 2020 in PubMed, Embase, and Cochrane (CENTRAL). Descriptive statistics were performed.

Results: We reviewed 14 studies, of …

2020-11-23_Michiganoverview_Covidschooloutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The School Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_102480---,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

In accordance with the Council of State and Territorial Epidemiologists’ outbreak definition, schools that have been found by their local health department to have two (2) or more COVID-19 cases who may have shared exposure at the school grounds and are not from the same household (with the exception of dorms and off-campus housing) are included. If your child’s school is …

Demystifying First-Time Mothers’ Postpartum Mental Health: A Phenomenological Study Of The Transition To Becoming A Mother, Megan Dooley Hussmann

Dissertations

Becoming a mother is a significant life event that can greatly impact maternal mental health. Understanding maternal mental health is an important interdisciplinary goal because it could lead to mother’s receiving better care and support from both mental health and medical professionals. Seven first-time mothers with a baby under the age of one were interviewed for a phenomenological qualitative study, which investigated first-time mothers’ postpartum mental health experiences. This study was guided by two research questions: How do new mothers experience their postpartum mental health in comparison to how they experienced their mental health before having their baby, and how …