Medicine and Health Sciences Commons^™

Venous Thromboembolism After Penetrating Femoral And Popliteal Artery Injuries: An Opportunity For Increased Prevention, Asanthi Ratnasekera, Odessa Pulido, Sandra Durgin, Sharon Nichols, Alicia Lozano, Danielle Sienko, Alexandra Hanlon, Niels D Martin

General Surgery Resident Research

Background: Trauma patients with penetrating vascular injuries have a higher rate of venous thromboembolism (VTE). The objective of this study was to determine the risk of VTE formation in penetrating femoral and popliteal vascular injuries and the effects of endovascular management of these injuries.

Methods: A retrospective study of Pennsylvania Trauma Outcome Study registry was conducted during a 5-year period (2013-2017). All adult patients with a penetrating mechanism with femoral/popliteal vascular injuries were studied. Primary outcome was incidence of VTE in patients with isolated arterial injuries versus combined arterial/venous injuries. Secondary endpoints were intensive care unit (ICU) length of stay …

Tulip-Screw Head Disjunction From Posterior C2 Fracture Fixation Instrumentation., Halle E K Burley, Darius S Ansari, Alexander Von Glinski, Ryan Goodmanson, Benjamin A Schell, Jens R Chapman, Rod J Oskouian

Articles, Abstracts, and Reports

This report presents an unusual case of instrumentation failure after posterior fixation of a C2 fracture and reviews currently available treatment alternatives. The patient, a 53-year-old female, initially presented to the emergency department at an outside facility with acute alcohol intoxication and acute neck pain following a fall from a ladder. CT demonstrated bilateral C2 pars fractures and unstable posteroinferior displacement of the posterior elements. She underwent an emergent C2 open-reduction internal fixation (ORIF) at the outside facility with 3.5 mm polyaxial synapse pedicle screws (DePuy Synthes, Switzerland). There were no known complications and the patient was discharged. Two years …

Electronic Fetal Monitoring Credentialing Examination: The First 4000., Mark Tomlinson, Sara A Brumbaugh, Marin O'Keeffe, Richard L Berkowitz, Mary D'Alton, Michael Nageotte

Articles, Abstracts, and Reports

No abstract provided.

Simultaneous Isolation Of Circulating Nucleic Acids And Ev-Associated Protein Biomarkers From Unprocessed Plasma Using An Ac Electrokinetics-Based Platform., Juan Pablo Hinestrosa, David J Searson, Jean M Lewis, Alfred Kinana, Orlando Perrera, Irina Dobrovolskaia, Kevin Tran, Robert Turner, Heath I Balcer, Iryna Clark, David Bodkin, Dave Hoon, Rajaram Krishnan

Articles, Abstracts, and Reports

The power of personalized medicine is based on a deep understanding of cellular and molecular processes underlying disease pathogenesis. Accurately characterizing and analyzing connections between these processes is dependent on our ability to access multiple classes of biomarkers (DNA, RNA, and proteins)-ideally, in a minimally processed state. Here, we characterize a biomarker isolation platform that enables simultaneous isolation and on-chip detection of cell-free DNA (cfDNA), extracellular vesicle RNA (EV-RNA), and EV-associated proteins in unprocessed biological fluids using AC Electrokinetics (ACE). Human biofluid samples were flowed over the ACE microelectrode array (ACE chip) on the Verita platform while an electrical signal …

Sex Moderates The Relationship That Number Of Professional Fights Has With Cognition And Brain Volumes., Lauren L Bennett, Steve J Stephen, Charles Bernick, Guogen Shan, Sarah J Banks

Articles, Abstracts, and Reports

Objective: Incidence of concussions and report of symptoms are greater among women across sports. While structural brain changes and cognitive declines are associated with repetitive head impact (RHI), the role of sex is not well-understood. This study aimed to determine if there is a moderating effect of sex on the relationship the number of professional fights has with cognitive functioning and regional brain volumes in a cohort of boxers, mixed martial artists, and martial artists. Methods: A total of 55 women were matched with 55 men based on age, years of education, ethnicity, and fighting style. Cognition was assessed via …

Cdca2 Inhibits Apoptosis And Promotes Cell Proliferation In Prostate Cancer And Is Directly Regulated By Hif-1Α Pathway., Yixiang Zhang, Yingduan Cheng, Zhaoxia Zhang, Zhongyuan Bai, Hongtao Jin, Xiaojing Guo, Xiaoyan Huang, Meiqi Li, Maolin Wang, Xing-Sheng Shu, Yeqing Yuan, Ying Ying

Articles, Abstracts, and Reports

Prostate cancer (PCa) is a major serious malignant tumor and is commonly diagnosed in older men. Identification of novel cancer-related genes in PCa is important for understanding its tumorigenesis mechanism and developing new therapies against PCa. Here, we used RNA sequencing to identify the specific genes, which are upregulated in PCa cell lines and tissues. The cell division cycle associated protein (CDCA) family, which plays a critical role in cell division and proliferation, is upregulated in the PCa cell lines of our RNA-Sequencing data. Moreover, we found that CDCA2 is overexpressed, and its protein level positively correlates with its histological …

The New Onset Of Dysphagia Four Years After Anterior Cervical Discectomy And Fusion: Case Report And Literature Review., Darius Ansari, Halle E K Burley, Alexander Von Glinski, Christopher Elia, Jens R Chapman, Rod J Oskouian

Articles, Abstracts, and Reports

Background: Dysphagia is a common complication immediately following anterior cervical spine surgery. However, its onset more than 1-year postoperatively is rare.

Case Description: A 45-year-old male initially underwent a C3-4 and C5-6 anterior cervical discectomy and fusion (ACDF). At age 49, 4 years later, he presented with worsening dysphagia accompanied by neck and right upper extremity pain. Radiographs demonstrated an extruded left C3 screw, which had migrated into the prevertebral soft tissues at the C4-C5 level; there was also loosening of the right C3 screw. The subsequent barium swallow study revealed that the screw was embedded in the pharyngeal wall. …

Intravenous Lidocaine As A Non-Opioid Adjunct Analgesic For Traumatic Rib Fractures., Jeff Choi, Kirellos Zamary, Nicolas B Barreto, Lakshika Tennakoon, Kristen M Davis, Amber W Trickey, David A Spain

Articles, Abstracts, and Reports

INTRODUCTION: Pain management is the pillar of caring for patients with traumatic rib fractures. Intravenous lidocaine (IVL) is a well-established non-opioid analgesic for post-operative pain, yet its efficacy has yet to be investigated in trauma patients. We hypothesized that IVL is associated with decreased inpatient opioid requirements among patients with rib fractures.

METHODS: We retrospectively evaluated adult patients presenting to our Level 1 trauma center with isolated chest wall injuries. After 1:1 propensity score matching patients who received vs did not receive IVL, we compared the two groups' average daily opioid use, opioid use in the last 24 hours of …

Triggering Receptor Expressed On Myeloid Cell 2 R47h Exacerbates Immune Response In Alzheimer's Disease Brain., Olena Korvatska, Kostantin Kiianitsa, Alexander Ratushny, Mark Matsushita, Neal Beeman, Wei-Ming Chien, Jun-Ichi Satoh, Michael O Dorschner, C Dirk Keene, Theo K Bammler, Thomas D Bird, Wendy H Raskind

Articles, Abstracts, and Reports

The R47H variant in the microglial triggering receptor expressed on myeloid cell 2 (TREM2) receptor is a strong risk factor for Alzheimer's disease (AD). To characterize processes affected by R47H, we performed an integrative network analysis of genes expressed in brains of AD patients with R47H, sporadic AD without the variant, and patients with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), systemic disease with early-onset dementia caused by loss-of-function mutations in TREM2 or its adaptor TYRO protein tyrosine kinase-binding protein (TYROBP). Although sporadic AD had few perturbed microglial and immune genes, TREM2 R47H AD demonstrated upregulation of interferon type I …

Cerebellar-Cortical Function And Connectivity During Sensorimotor Behavior In Aging Fmr1 Gene Premutation Carriers., Walker S Mckinney, James Bartolotti, Pravin Khemani, Jun Yi Wang, Randi J Hagerman, Matthew W Mosconi

Articles, Abstracts, and Reports

INTRODUCTION: Premutation carriers of the FMR1 gene are at risk of developing fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disease characterized by motor, cognitive, and psychiatric decline as well as cerebellar and cerebral white matter pathology. Several studies have documented preclinical sensorimotor issues in aging premutation carriers, but the extent to which sensorimotor brain systems are affected and may represent early indicators of atypical neurodegeneration has not been determined.

MATERIALS AND METHODS: Eighteen healthy controls and 16 FMR1 premutation carriers (including five with possible, probable, or definite FXTAS) group-matched on age, sex, and handedness completed a visually guided precision gripping …

Current Advancements In The Management Of Spinal Cord Injury: A Comprehensive Review Of Literature., Manan Shah, Catherine Peterson, Emre Yilmaz, Dia Radi Halalmeh, Marc Moisi

Articles, Abstracts, and Reports

Background: Spinal cord injury (SCI) carries debilitating lifelong consequences and, therefore, requires careful review of different treatment strategies.

Methods: An extensive review of the English literature (PubMed 1990 and 2019) was performed regarding recent advances in the treatment of SCI; this included 46 articles written over 28 years.

Results: Results of this search were divided into five major modalities; neuroprotective and neuroregenerative pharmaceuticals, neuromodulation, stem cell-based therapies, and various external prosthetic devices. Lately, therapeutic strategies were mainly focused on two major areas: neuroregeneration and neuroprotection.

Conclusion: Despite recent advancements, more clinical trials on a larger scale and further research are …

Secukinumab Provides Sustained Improvements In The Signs And Symptoms Of Psoriatic Arthritis: Final 5-Year Results From The Phase 3 Future 1 Study., Philip Mease, Arthur Kavanaugh, Andreas Reimold, Hasan Tahir, Juergen Rech, Stephen Hall, Piet Geusens, Pascale Pellet, Eumorphia Maria Delicha, Luminita Pricop, Shephard Mpofu

Articles, Abstracts, and Reports

OBJECTIVE: To report the 5-year efficacy and safety of secukinumab in the treatment of patients with psoriatic arthritis (PsA) in the FUTURE 1 study (NCT01392326).

METHODS: Following the 2-year core trial, eligible patients receiving subcutaneous secukinumab entered a 3-year extension phase. Results are presented for key efficacy endpoints for the secukinumab 150-mg group (n = 236), including patients who escalated from 150 to 300 mg (approved doses) starting at week 156. Safety is reported for all patients (n = 587) who received 1 dose or more of study treatment.

RESULTS: Overall, 81.8%% (193 of 236) of patients in the secukinumab …

Association Of Use Of Rehabilitation Services With Development Of Dementia Among Patients With Rheumatoid Arthritis: Analysis Of Domestic Data In Taiwan, Ming-Chi Lu, Hanoch Livneh, Chieh-Tsung Yen, Hua-Lung Huang, Miao-Chiu Lin, Shu-Wen Yen, Ning-Sheng Lai, Tzung-Yi Tsai

Counselor Education Faculty Publications and Presentations

Objectives: Rheumatoid arthritis (RA) was found to trigger the higher risk of dementia. Limited information, however, is available on whether the use of rehabilitation services (RS), an integral part of healthcare programs, can lessen dementia risk for RA subjects. The aim of this study was to determine the relationship of RS use to the development of dementia in RA patients.

Methods: We identified 2,927 newly diagnosed patients with RA, 20–70 years of age between 1998 and 2007, from a national health insurance database. 965 patients from this sample received RS, and 1,962 patients were designated as a control group (non-RS …

Association Of Chinese Herbal Medicines Use With Development Of Chronic Obstructive Pulmonary Disease Among Patients With Rheumatoid Arthritis: A Population-Based Cohort Study, Miao-Chiu Lin, Hanoch Livneh, Wei-Jen Chen, Ning-Sheng Lai, Ming-Chi Lu, Tzung-Yi Tsai

Counselor Education Faculty Publications and Presentations

Purpose: Rheumatoid arthritis (RA) patients appear to report a higher risk of chronic obstructive pulmonary disease (COPD). While Chinese herbal medicine (CHMs) is proven to lower COPD risk, the scientific evidence regarding its effect in relation to COPD onset among them is limited. This longitudinal cohort study aimed to determine the relationship between CHMs use and the COPD risk in RA patients.

Methods: Using the nationwide claim data, 8349 patients newly diagnosed with RA and simultaneously free of COPD between 1998 and 2010 were eligible for enrollment. From this sample, we enrolled 3360 CHMs users and 3360 non-CHMs users, randomly …

Progressive Shifts In The Gut Microbiome Reflect Prediabetes And Diabetes Development In A Treatment-Naive Mexican Cohort., Christian Diener, María De Lourdes Reyes-Escogido, Lilia M Jimenez-Ceja, Mariana Matus, Claudia M Gomez-Navarro, Nathaniel D Chu, Vivian Zhong, M Elizabeth Tejero, Eric Alm, Osbaldo Resendis-Antonio, Rodolfo Guardado-Mendoza

Articles, Abstracts, and Reports

Type 2 diabetes (T2D) is a global epidemic that affects more than 8% of the world's population and is a leading cause of death in Mexico. Diet and lifestyle are known to contribute to the onset of T2D. However, the role of the gut microbiome in T2D progression remains uncertain. Associations between microbiome composition and diabetes are confounded by medication use, diet, and obesity. Here we present data on a treatment-naive cohort of 405 Mexican individuals across varying stages of T2D severity. Associations between gut bacteria and more than 200 clinical variables revealed a defined set of bacterial genera that …

Cri Iatlas: An Interactive Portal For Immuno-Oncology Research., James A Eddy, Vésteinn Thorsson, Andrew E Lamb, David L Gibbs, Carolina Heimann, Jia Xin Yu, Verena Chung, Yooree Chae, Kristen Dang, Benjamin G Vincent, Ilya Shmulevich, Justin Guinney

Articles, Abstracts, and Reports

The Cancer Research Institute (CRI) iAtlas is an interactive web platform for data exploration and discovery in the context of tumors and their interactions with the immune microenvironment. iAtlas allows researchers to study immune response characterizations and patterns for individual tumor types, tumor subtypes, and immune subtypes. iAtlas supports computation and visualization of correlations and statistics among features related to the tumor microenvironment, cell composition, immune expression signatures, tumor mutation burden, cancer driver mutations, adaptive cell clonality, patient survival, expression of key immunomodulators, and tumor infiltrating lymphocyte (TIL) spatial maps. iAtlas was launched to accompany the release of the TCGA …

Persistent Reduction In The Age Adjusted Mortality Rate From Aortic Valve Surgery In The United State With Elimination Of Gender Gap In Recent Years., Mohammad Reza Movahed, Sara Etemad, Mehrnoosh Hashemzadeh, Mehrtash Hashemzadeh

Articles, Abstracts, and Reports

BACKGROUND: Advancement in the surgical techniques should translate into better outcome. The goal of this study was to evaluate mortality trends from aortic valve surgery in the United State using large inpatient database.

METHOD: The Nationwide Inpatient Sample (NIS) database was used to calculate the age-adjusted mortality rate from aortic valve surgery from 1988 to 2011 in the United State using ICD-9 coding for aortic valve surgery.

RESULTS: We found that age adjusted mortality rate from aortic valve surgery gradually decreased from 1988 until end of study in 2011 to the lowest level with elimination of gender gap that was …

Recent Advances In The Understanding And Management Of Primary Hyperparathyroidism., Melanie Goldfarb, Frederick R Singer

Articles, Abstracts, and Reports

Primary hyperparathyroidism is a hormonal disorder whose prevalence is approximately 1-2% in the United States of America. The disease has become more recognizable to clinicians in an earlier phase and, at present, patients can be diagnosed with "classic", "normocalcemic", "normohormonal", or "mild, asymptomatic" primary hyperparathyroidism. Surgery, with a focused parathyroidectomy when possible, or a four-gland exploration, is the only way to cure the disease. Cure is determined by use of intra-operative parathyroid hormone monitoring with long-term cure rates ranging from 90-95%. Newer adjuncts to surgery include CT or PET imaging and near-infrared immunofluorescence. This article highlights updates in parathyroid disease …

Unmet Need In Rheumatology: Reports From The Targeted Therapies Meeting 2019., Kevin L Winthrop, Michael E Weinblatt, Joan Bathon, Gerd R Burmester, Philip Mease, Leslie Crofford, Vivian Bykerk, Maxime Dougados, James Todd Rosenbaum, Xavier Mariette, Joachim Sieper, Fritz Melchers, Bruce N Cronstein, Ferry C Breedveld, Joachim Kalden, Josef S Smolen, Daniel Furst

Articles, Abstracts, and Reports

OBJECTIVES: To detail the greatest areas of unmet scientific and clinical needs in rheumatology.

METHODS: The 21st annual international Advances in Targeted Therapies meeting brought together more than 100 leading basic scientists and clinical researchers in rheumatology, immunology, epidemiology, molecular biology and other specialties. During the meeting, breakout sessions were convened, consisting of 5 disease-specific groups with 20-30 experts assigned to each group based on expertise. Specific groups included: rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematosus and other systemic autoimmune rheumatic diseases. In each group, experts were asked to identify unmet clinical and translational research needs in general …

Synthesis And Characterization Of Tripodal-Imidazolium And Pyridazine Ruthenium Complexes And Their Associated Ligands, Jacqueline L. Kowalke

Lewis Honors College Capstone Collection

Photochemical therapy (PCT) is a relatively new treatment for cancer. PCT, unlike photodynamic therapy (PDT), does not require oxygen though it may be one of the mechanisms that the photosensitizer uses to destroy cancerous cells. Ruthenium complexes have recently entered clinical trials for the treatment of cancer. TLD1433, a ruthenium coordination complex, has entered phase II clinical trials for the treatment of non-muscular invasive bladder cancer. In this compound, the ligands are coordinated via nitrogen bonds, but in this paper, carbon-coordinated complexes are explored. Coordination of N-heterocyclic carbene (NHC) ligands to ruthenium is suspected to provide a different type of …

Multi-Modal Medical Imaging Analysis With Modern Neural Networks, Gongbo Liang

Theses and Dissertations--Computer Science

Medical imaging is an important non-invasive tool for diagnostic and treatment purposes in medical practice. However, interpreting medical images is a time consuming and challenging task. Computer-aided diagnosis (CAD) tools have been used in clinical practice to assist medical practitioners in medical imaging analysis since the 1990s. Most of the current generation of CADs are built on conventional computer vision techniques, such as manually defined feature descriptors. Deep convolutional neural networks (CNNs) provide robust end-to-end methods that can automatically learn feature representations. CNNs are a promising building block of next-generation CADs. However, applying CNNs to medical imaging analysis tasks is …

Perceptions, Attitudes, Self-Efficacy, And Behaviors Of Mouthguard Use Among Collegiate Athletes, Heather Prosser

All Graduate Theses, Dissertations, and Other Capstone Projects

With the high risk of dental trauma in contact sports, it is important that all athletes have a strong foundation of how to prevent such injuries. Properly fitted mouthguards are the best available protective equipment to prevent orofacial trauma; however, previous research has found them underutilized, with the need for evidence-based interventions to promote mouthguard use among athletes. This study used a descriptive, cross-sectional, correlational research design, focusing on studying collegiate athletes at one large, Midwestern university, to determine their current attitudes, perceptions, self-efficacy, and behaviors of mouthguard use during participation in a contact sport. A convenience sampling technique was …

Human Papillomavirus (Hpv) Infection And Vaccine Knowledge And Attitudes Among University Students, Mckenzie Schmitz

All Graduate Theses, Dissertations, and Other Capstone Projects

HPV is the “most common sexually transmitted infection,” with approximately four out of five sexually active individuals getting infected at some point in their lives (Planned Parenthood, n.d.b, para.1). Cancers of the throat, mouth, cervix, anus, penis, and vagina have all been linked to HPV infections. In addition to being tested for HPV, the utilization of barrier methods and reduction of risky sexual risk behaviors, are the best ways to prevent and treat sexually transmitted infections. This study contributes to existing literature on university students’ knowledge and attitudes about HPV infections and the vaccination. This study was conducted using descriptive, …

Do Open Access Dental Articles Enjoy Higher Altmetric Attention Scores, Twitter, Facebook, News, Wikipedia, Blog Mentions, Mendeley Readers And Citations?, Jafar Kolahi, Saber Khazaei, David G. Dunning, Edward F. Rossomando

Journal Articles: College of Dentistry

In order to access articles published in conventional (non-open access) journals, scientists must utilize tools such as subscriptions, site licenses or pay-per-view charges. In contrast, open access articles can be accessed without financial, legal or technical barriers. A large-scale study estimated that at least 28% of the academic literature is open access (19 million in total) and that this percentage is growing.^[1] A recent survey showed an open access rate in field of dentistry at 45.8%.^[2] It has been demonstrated that open access articles had 8% to 40% higher citations compared to non-open access articles; this has been …

Pestilence And Poverty: The Great Influenza Pandemic And Underdevelopment In The New South, 1918-1919, Andrew Kishuni

Honors Undergraduate Theses

This study examines the "Spanish" influenza pandemic of 1918-1919 in the U.S. South, using case-studies of Jacksonville, Savannah, New Orleans, and Nashville to sculpt a "Southern flu" more identical to the Global South and the developing world than the rest of the U.S. I examine poverty and political and economic paralysis in the years between the end of Reconstruction and 1918, and the poor results of political indifference on public health and disease control. I also analyze the social and institutional racism against persons of color that defined high infectious disease mortality in Southern cities.

I argue that Southerners faced …

Addressing The Elephant On The Stage: Mental Health In Theatre Education, Alexandra M. Meridionale

Honors Undergraduate Theses

This thesis examined the ways in which present-day 6^th through 12^th grade theatre educators approach the topic of mental health, both implicitly and explicitly, in theatre education. Through a survey of existing literature, as well as interviews with 6^th through 12^th grade theatre educators, the researcher examined ways in which theatre educators were aware of the mental health needs of their students in any of the following capacities: explicit discussions regarding mental health, theatre curriculum, show selection, script analysis, and casting choices.

The reveal the educator perception that mental health issues are increasingly relevant to 6 …

Unregulated Health Research Using Mobile Devices: Ethical Considerations And Policy Recommendations, Mark A. Rothstein, John T. Wilbanks, Laura M. Beskow, Kathleen M. Brelsford, Kyle B. Brothers, Megan Doerr, Barbara J. Evans, Catherine Hammack-Aviran, Michelle L. Mcgowan, Stacey A. Tovino

Law Faculty Scholarship

The rapid expansion of mobile health (mHealth) technologies has enabled large-scale collection of health-related data outside traditional clinical research environments. This article examines ethical and regulatory challenges posed by “unregulated” health research conducted through mobile applications, wearable devices, and consumer digital platforms. Drawing on legal analysis and ethical scholarship, the authors explore gaps in the U.S. regulatory framework, particularly where research activities fall outside the scope of the Common Rule or other human-subject protections. The paper identifies key ethical risks, including inadequate informed consent, privacy vulnerabilities, unclear data governance, and limited accountability for commercial entities conducting research. To address these …

Protecting Participants In Genomic Research: Understanding The "Web Of Protections" Afforded By Federal And State Law, Leslie E. Wolf, Catherine M. Hammack, Erin Fuse Brown, Kathleen M. Brelsford, Laura M. Beskow

Law Faculty Scholarship

Advances in genomic research increasingly rely on large-scale datasets combining biospecimens, electronic health records, and behavioral data. This article examines the complex legal framework governing privacy and confidentiality protections for participants in genomic research in the United States. Through a combination of qualitative interviews with national thought leaders and systematic legal analysis of federal and state statutes, the authors assess how existing legal protections operate in practice. The study evaluates several hypothetical research scenarios—including the return of individual results, data breaches, and legal demands for data access—to illustrate how laws such as the Common Rule, HIPAA, the Genetic Information Nondiscrimination …

Developing Model Biobanking Consent Language: What Matters To Prospective Participants?, Laura M. Beskow, Catherine Hammack-Aviran, Kathleen M. Brelsford

Law Faculty Scholarship

Background: Efforts to improve informed consent have led to calls for providing information a reasonable person would want to have, in a way that facilitates understanding of the reasons why one might or might not want to participate. At the same time, advances in large-scale genomic research have expanded both the opportunities and the risks for participants, families, and communities. To advance the use of effective consent materials that reflect this landscape, we used empirical data to develop model consent language, as well as brief questions to assist people in thinking about their own values relative to participation.

Methods: We …

Expert Perspectives On Oversight For Unregulated Mhealth Research: Empirical Data And Commentary, Laura M. Beskow, Catherine Hammack-Aviran, Kathleen M. Brelsford, P Pearl O'Rourke

Law Faculty Scholarship

This study explores expert perspectives on oversight mechanisms for unregulated mobile health (mHealth) research conducted outside traditional regulatory frameworks. Through qualitative interviews with stakeholders including patient advocates, researchers, regulators, and technology developers, the authors examine concerns surrounding ethical protections in research utilizing data from mobile applications and devices. Participants highlighted risks associated with inadequate study design, lack of informed consent, and insufficient safeguards for participant privacy and autonomy. Experts proposed a range of potential oversight mechanisms, including voluntary ethical review processes, industry standards, and expanded institutional policies. The findings underscore the growing ethical challenges posed by nontraditional research environments and …