Medicine and Health Sciences Commons^™

John Timothy Wright, James Bawden Appointed Next Editor In Chief Of The Jada, American Dental Association

News Releases

This collection includes standard news releases, information kits and other documents distributed for publicity, information, announcements of events, etc. as issued from the ADA. Items included in this collection are archival and any costs, links, contact information, or other figures may be out of date. Please contact the ADA to verify information.

Summary Of Ada Guidance During The Covid-19 Crisis, American Dental Association

News Releases

This collection includes standard news releases, information kits and other documents distributed for publicity, information, announcements of events, etc. as issued from the ADA. Items included in this collection are archival and any costs, links, contact information, or other figures may be out of date. Please contact the ADA to verify information.

The Indiana University School Of Dentistry To Host The 2020 Give Kids A Smile® National Kickoff, American Dental Association

News Releases

This collection includes standard news releases, information kits and other documents distributed for publicity, information, announcements of events, etc. as issued from the ADA. Items included in this collection are archival and any costs, links, contact information, or other figures may be out of date. Please contact the ADA to verify information.

Fluorescent Sensor Arrays Can Predict And Quantify The Composition Of Multicomponent Bacterial Samples, Denis Svechkarev, Marat Sadykov, Lucas J. Houser, Kenneth W. Bayles, Aaron M. Mohs

Journal Articles: Pathology and Microbiology

Fast and reliable identification of infectious disease agents is among the most important challenges for the healthcare system. The discrimination of individual components of mixed infections represents a particularly difficult task. In the current study we further expand the functionality of a ratiometric sensor array technology based on small-molecule environmentally-sensitive organic dyes, which can be successfully applied for the analysis of mixed bacterial samples. Using pattern recognition methods and data from pure bacterial species, we demonstrate that this approach can be used to quantify the composition of mixtures, as well as to predict their components with the accuracy of ~80% …

An Integrated Computational And Experimental Study To Investigate Staphylococcus Aureus Metabolism, Mohammad Mazharul Islam, Vinai Chittezham Thomas, Matthew Van Beek, Jong-Sam Ahn, Abdulelah A. Alqarzaee, Chunyi Zhou, Paul D. Fey, Kenneth W. Bayles, Rajib Saha

Journal Articles: Pathology and Microbiology

Staphylococcus aureus is a metabolically versatile pathogen that colonizes nearly all organs of the human body. A detailed and comprehensive knowledge of staphylococcal metabolism is essential to understand its pathogenesis. To this end, we have reconstructed and experimentally validated an updated and enhanced genome-scale metabolic model of S. aureus USA300_FPR3757. The model combined genome annotation data, reaction stoichiometry, and regulation information from biochemical databases and previous strain-specific models. Reactions in the model were checked and fixed to ensure chemical balance and thermodynamic consistency. To further refine the model, growth assessment of 1920 nonessential mutants from the Nebraska Transposon Mutant Library …

Health Professions Division Catalog_2020-2021, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Loss Of Trp53 (P53) Accelerates Tumorigenesis And Changes The Tumor Spectrum Of Sjl/J Mice., Jane Branca, Benjamin E. Low, Ruth L. Saxl, Jennifer K Sargent, Rosalinda A. Doty, Michael V. Wiles, Beth L Dumont, Muneer G. Hasham

Faculty Research 2020

Known as the guardian of the genome, transformation-related protein 53 (TRP53) is a well -known tumor suppressor. Here, we describe a novel TRP53 deficient mouse model on a tumor prone background-SJL/J mice. The absence of TRP53 (TRP53 nullizygosity) leads to a shift in the tumor spectrum from a non-Hodgkin's-like disease to thymic lymphomas and testicular teratomas at a very rapid tumor onset averaging ~12 weeks of age. In haplotype studies, comparing tumor prone versus tumor resistant Trp53 null mouse strains, we found that other tumor suppressor, DNA repair and/or immune system genes modulate tumor incidence in TRP53 null strains, suggesting …

Deep Functional And Molecular Characterization Of A High-Risk Undifferentiated Pleomorphic Sarcoma., Noah E Berlow, Catherine S Grasso, Michael J Quist, Mingshan Cheng, Regina Gandour-Edwards, Brian S Hernandez, Joel E Michalek, Christopher Ryan, Paul Spellman, Ranadip Pal, Lynn S Million, Mark Renneker, Charles Keller

Faculty Research 2020

Nonrhabdomyosarcoma soft-tissue sarcomas (STSs) are a class of 50+ cancers arising in muscle and soft tissues of children, adolescents, and adults. Rarity of each subtype often precludes subtype-specific preclinical research, leaving many STS patients with limited treatment options should frontline therapy be insufficient. When clinical options are exhausted, personalized therapy assignment approaches may help direct patient care. Here, we report the results of an adult female STS patient with relapsed undifferentiated pleomorphic sarcoma (UPS) who self-drove exploration of a wide array of personalized Clinical Laboratory Improvement Amendments (CLIAs) level and research-level diagnostics, including state of the art genomic, proteomic,

Understanding The Healthcare Experiences And Needs Of African Immigrants In The United States: A Scoping Review, Ogbonnaya I. Omenk, Dennis P. Watson, Hugh C. Hendrie

Scholarship and Professional Work – COPHS

Background: Africans immigrants in the United States are the least-studied immigrant group, despite the research and policy efforts to address health disparities within immigrant communities. Although their healthcare experiences and needs are unique, they are often included in the “black” category, along with other phenotypically-similar groups. This process makes utilizing research data to make critical healthcare decisions specifically targeting African immigrants, difficult. The purpose of this Scoping Review was to examine extant information about African immigrant health in the U.S., in order to develop lines of inquiry using the identified knowledge-gaps.

Methods: Literature published in the English language between 1980 …

Vaping Education In The Adolescent Population, Megan M. Meinders, Morgan Sauvage, Shania Scheidt, Alexa Trakalo

All Electronic Theses and Dissertations

The prevalence of e-cigarette use in the United States is drastically rising, deeming vaping an epidemic. With the surge in the use of e-cigarettes, cases of e-cigarette or vaping product use-associated lung injury (EVALI) are simultaneously increasing. The most common tobacco product used among adolescents are e-cigarettes, posing serious concerns regarding health consequences. Adolescents are unaware of the potential harmful effects of e-cigarette use, due to the lack of vaping education provided in high school curriculums.The purpose of this research project is to educate high school students about the harmful effects of e-cigarette use. The need for vaping education was …

Hepatitis C Education, Testing, And Treatment In Homeless Shelters: Models For Linkage To Care In High-Risk Populations, Erin H. Higley

All Electronic Theses and Dissertations

Background: With the increase of IV drug use, Hepatitis C viral (HCV) infections have increased considerably among the homeless population. The introduction of direct-acting antiviral (DAA) medications has made treating marginalized populations much easier. However, getting homeless patients and people who inject drugs (PWID) linked to care remains a challenge worldwide. More research is needed to ensure that all persons with HCV are able to access treatment regardless of social or economic status. Purpose: The purpose of this critical review of research is to identify models of care for treating HCV among the homeless. This review was done to support …

Aging In Place: Causes And Importance Of Fall Prevention Education, Molly Banks, Danielle Halstead, Mariah Leroux

Critically Appraised Topics

Falls are a significant concern for older community-dwelling adults’ ability to age in place, specifically those who aged 60 and older. Many factors contribute to the risk of falls in older adults that need to be addressed by health care facilities, home health providers, and caretakers. Occupational therapy has a role to educate older adults, as well as health care providers on how to prevent the risk factors of older adults and falls. The purpose of this CAT is to take a deeper look at why this population has so many falls and examine the research addressing education and risk …

Learning To Jump Like Corbin Bleu: The Physics Behind Jump Rope, Caroline Camfield

Mahurin Honors College Capstone Experience/Thesis Projects

This project seeks to determine how engineering can be applied to the sport of jump rope so that athletes may better understand the science behind the sport and apply it to improve their performance in “speed jumping.” This style of jump rope consists of a jumper alternating their feet, with the rope passing under them with each step. Several types of ropes, handles, rope lengths, and widths between a jumper’s handles were tested to determine correlations between each variable and different STEM concept. These findings were then transitioned into a lesson plan so that both the jumpers and coaches could …

Assessing Biomass Fuel Consumption In Kasigau, Kenya As A Predictor Of Hypertension, Conner Hounshell

Mahurin Honors College Capstone Experience/Thesis Projects

Cardiovascular disease is the leading cause of death globally and disproportionately affects low- and middle-income countries, such as Kenya. Hypertension is the leading risk factor for cardiovascular disease and is influenced by a variety of factors such as diet, tobacco use, and genetics. One such factor linked to hypertension is exposure to air pollution, but minimal research exists on the effects of household air pollution. Hypertension that is not related to common Western risk indicators, such as waist-to-hip ratio, body mass indices, and hypercholestorlemia, is prevalent in the community of Kasigau, Kenya, along with the prevalence of risks for household …

Assessing Access To Healthcare For Limited English Proficient Patients, Hannah Bergamini

Mahurin Honors College Capstone Experience/Thesis Projects

Patients with limited English skills often face additional struggles when accessing medical care. These patients, referred to as limited English proficient (LEP) patients, are unable to communicate directly with their physician. This lack of direct communication typically results in unique challenges for the patient and provider. Due to these challenges, LEP patients often have poorer health statuses and experience poorer health outcomes. However, when provided with access to qualified medical interpreters, many of these challenges facing LEP patients can be ameliorated. Therefore, using qualified interpreters is an important component in improving the access to healthcare for LEP patients. To determine …

Creating A Social Communication Module For Youth With Autism Spectrum Disorder, Erin Walton

Mahurin Honors College Capstone Experience/Thesis Projects

Research (Hales, Carroll, Fryar, & Ogden, 2017) shows that those with autism spectrum disorder (ASD) often experience poorer physical health and fewer opportunities for social interactions than typically developing peers. As the prevalence of ASD increases, it is essential to consider effective interventions that target multiple skill areas for individuals seeking therapy. Youth ages 9 to 17 with ASD may experience physical health and social communication benefits from the implementation of a social communication curriculum module that could potentially be incorporated with Bingocize®, an online application that incorporates bingo with physical exercise, as well as educational content. Social communication educational …

Impact Of Geographic Location And Social Determinants Of Health On Lung Cancer Incidence And Mortality Rates, Katherine Ashley

Mahurin Honors College Capstone Experience/Thesis Projects

This paper studies the effect of geographic location and socioeconomic status, specifically level of education and income, on rates of incidence and mortality of lung and bronchus cancer. While some prior studies have focused on socioeconomic status’ and global geographic location’s impact on these rates, few have focused on the impact in Appalachian Kentucky and non-Appalachian Kentucky. In this paper, level of education and income are controlled for using four variables: median household income, percentage of persons in poverty, percentage of high school graduates or higher who are at least 25, and percentage of persons with a bachelor’s degree or …

A Study Of Kindergarten Language Screening Performance Across Schools With Variable Demographic Compositions, Baylee Lackey

Mahurin Honors College Capstone Experience/Thesis Projects

The Quick Interactive Language Screener (QUILS) for language impairment was designed and normed for children of diverse backgrounds. This study examined the utility of the QUILS in a diverse school district by comparing failure rates across five elementary schools. Schools varied in racial composition (non-White range: 20.45 – 80%) and socioeconomic status (free/reduced lunch qualified range: 35.35 – 100%). Among 321 currently-enrolled kindergartners, 272 completed the QUILS. Using author recommendations for kindergarten-aged cutoff scores, the district-wide screening failure rate for primarily monolingual English speakers (n = 212; via parent questionnaire) was 16.51% (range: 7.69 – 34.29% per school). Failure rates …

The Role Of Mitochondrial Pyruvate Carrier 1 (Mpc1) In Heart Failure And Its Implications For Cardiac Recovery, Obadiah Issachar Kirk

Mahurin Honors College Capstone Experience/Thesis Projects

Heart failure (HF) is a complex syndrome with high mortality rates around the world. HF also has diverse etiology as many things contribute such as hypertension, obesity, coronary artery disease, inflammation, and cardiac arrhythmias. Studies have shown that unloading of a failing heart with a left ventricular assist device (LVAD) can lead to cardiac recovery in a subpopulation of individuals with advanced HF. RNA-sequencing and protein expression analysis of myocardial tissue from HF patients who underwent the LVAD implant and heart transplant indicated that subpopulation of HF patients who responded to LVAD unloading had significantly lower levels of mitochondrial pyruvate …

Technology In Healthcare: How Artificial Intelligence Will Revolutionize The Profession, Ashley L. Mccowan

Kentucky Journal of Undergraduate Scholarship

The topic of artificial intelligence is a hot topic in the U.S. healthcare system and despite some uncertainties, continues to be increasingly integrated into healthcare delivery. Artificial intelligence can be used for different purposes including but not limited to data storage, decision making and image analysis. Critics of artificial intelligence in healthcare are skeptical of its ability to provide security of medical information and afraid that it will eventually replace the need for human healthcare workers. Although the critics skepticisms seem rational, further research of artificial intelligence in healthcare shows that those fears are not based on fact. Artificial intelligence …

Side Effects And Efficacy Of Isotretinoin In College Students, Brittany Smith

Mahurin Honors College Capstone Experience/Thesis Projects

Acne vulgaris is a serious disease that can have serious consequences for the person who has the condition. Acne can occur on the face, chest, back, and among other locations on the body. Its pathogenesis is complex and has many factors. Ahmad (2015), states acne involves abnormal keratinization, hormonal dysfunction and immune hypersensitivity. This condition can range from mild, moderate, or severe. Acne can be debilitating to the person who is struggling with it. Acne can occur at any age, but it is seen more often in adolescents. According to Marron, Tomas-Aragones, and Boira (2013), acne is prevalent in up …

Immunologic Analysis Of Non-Small Cell Lung Cancer In People Living With Hiv, Ramsey Yusuf

Yale Medicine Thesis Digital Library

Among people living with HIV (PLWH), non-small cell lung cancer (NSCLC) has emerged as the most common non-AIDS defining cancer and a leading cause of death. PLWH with NSCLC are diagnosed at younger ages and demonstrate worse outcomes compared to the general population. Global immune dysregulation in the setting of HIV infection may account for these disparities, however little is known about the immunobiology of HIV-associated NSCLC. The goal of this study was to investigate the clinical and pathology of NSCLC in PLWH. This retrospective cohort study examined HIV-associated and uninfected NSCLC cases within Yale-New Haven Hospital between 2000-2016. Medical …

Maternal Anxiety And Neural Responses To Infant Cues, Emily Vancor

Yale Medicine Thesis Digital Library

Maternal anxiety is highly prevalent during pregnancy and the postpartum period and is associated with disruptions to children’s socioemotional development. These long-term outcomes are thought to be mediated in part by anxiety’s effects on parenting and parental sensitivity to infant cues. Recent event-related potential (ERP) studies have found a positive association between generalized anxiety symptoms during the perinatal time and enhanced sustained processing of neutral infant faces. It has been suggested that for perinatal women with anxiety, the uncertainty of how an infant with a neutral expression may be feeling could be experienced as distressing, leading to enhanced sustained neural …

Graduate Medical Education Annual Report 2019-2020, Children's Mercy Hospital

GME Annual Reports

Annual report of the Children's Mercy Hospital Graduate Medical Education department, including pediatric residency, internal medicine/pediatrics residency, fellowship programs, medical students, continuing medical education, and library services.

Ddx 2.0: Efficacy Of A Differential Diagnosis Course For Ms3s Considering Primary Care And Non-Primary Care Specialties, Maya V. Prabhu

Scholarship in Medicine - All Papers

Objective: To assess if medical students interested in pursuing a primary care specialty are more receptive and have a more positive attitude towards formulating differential diagnoses (DDx) using metamemory techniques (MMTs). Methods: Cross-sectional analysis of data obtained from 113 MS3 students from the Boonshoft School of Medicine. Students generated timed DDx for a clinical case before and after an instructional didactic session about MMTs. Demographic data (including intended medical specialty and attitudes towards the overall process) were collected. Paired t-test compared screened and unscreened DDx before and after the intervention. Mixed-repeated measures ANOVA compared pre- and post- intervention screened and …

Depression And Disability In The United States, Colleen Pennington

Scholarship in Medicine - All Papers

Objective: To compare the prevalence of cognitive disabilities, mobility disabilities, and depression rates by varying categories including U.S. State, gender, and region. Methods: Data was obtained from the CDC Wonder data set for the prevalence of cognitive and mobility disabilities from the U.S. states for the years 2017-2018. Data was also obtained from the CDC for incidence of depression among the general population and those identifying with any disability. Data was analyzed with ANOVA and t-tests using SPSS. Results: Results reveal a significant difference in disability type and gender throughout the United States. There is also a significant difference in …

Differences In Social Determinants Of Health Between Rural And Urban Counties Of Ohio, Megan E. Luft

Scholarship in Medicine - All Papers

Objective: The objective of this study is to investigate any possible differences in social determinants of health between rural and urban counties of Ohio and how the determinants relate to each other. Methods: All data for each variable (percentage of population who have some college education, food insecurity rate, number of primary care physicians per population, average mentally unhealthy days for adults in a month, drug overdose death rate, life expectancy, and child poverty rate) was collected through County Health Rankings and Roadmaps from either statewide or nationwide programs through different studies and surveys from 2013-2017. I utilized descriptive statistics, …

The Effects Of Daily Sunlight Levels On Suicide Rates, Amna Amin

Scholarship in Medicine - All Papers

The correlation between sunlight and mental health has been long studied and is even involved in the development of Seasonal Affective Disorder (SAD), with subsequent development of light therapy for affected individuals. This points towards the question of the effects of varying levels of daily sunlight in the United States on rates of suicide – a reflection of the extreme state of suboptimal mental health. I have ventured to study this question, using publicly available data on the daily sunlight levels in various states in the U.S. during each month of the year and the rates of suicide in those …

The Relationship Between Asthma, Race & Fine Particulate Matter In The United States, Samantha Mcknight

Scholarship in Medicine - All Papers

Objective: To assess how environment and race may impact childhood asthma prevalence. Methods: I analyzed data from CDC WONDER (www.wonder.cdc.gov). I performed descriptive statistics on average fine particulate matter for various states, as well as descriptive statistics on childhood asthma prevalence for various states. I determined if there was a correlation between states with higher prevalence of childhood asthma and states with higher levels of fine particulate matter using Pearson correlation. I used ANOVA with post hoc test to determine childhood asthma prevalence based on race/ ethnicity in the various states.

Results: The mean fine particulate matter in the 49 …

The Relationship Between Upstream Variables And Diabetes In Ohio, Brenna Lammers

Scholarship in Medicine - All Papers

Chronic illness is a significant contributor to disease burden in the US. Among these chronic conditions, diabetes is one of the most prevalent. Knowing the relationships between various factors and the prevalence of diabetes would be beneficial to creating targeted approaches to address this major public health problem. Therefore, the objective of this project was to elucidate the relationship between social determinants of health (unemployment, food environment index, and access to exercise opportunities) and access to care variables (ratio of population to primary care physicians and percent uninsured) with prevalence of diabetes by county in Ohio. This was done through …