Medicine and Health Sciences Commons^™

2020 Edition, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - 2020 Edition

Strategic Planning For A Psychosocial Occupational Therapy Program: A Swot Analysis, Kellie Roy

OT Student Capstones

PURPOSE

To examine and evaluate the Northern Arizona Veterans Affairs Healthcare System (NAVAHCS) psychosocial occupational therapy (OT) program using a SWOT analysis to inform solution-oriented strategies for future directions of the program.

A Comparison Of Populations: Formerly Incarcerated Men With Substance Use Disorder And Adolescent Psychiatric Patients, Jeanie Fairchild

OT Student Capstones

Aims of the project:

• Equip Maricopa Reentry Center (MRC) residents with life skills necessary for successful reentry.
• Utilize knowledge gained at MRC to teach life skills to adolescents patients at St. Luke’s Behavioral Center (SLBC).

Neutrophils Are Mediators Of Metastatic Prostate Cancer Progression In Bone, Diane L. Costanzo-Garvey, Tyler Keeley, Adam J. Case, Gabrielle F. Watson, Massar Alsamraae, Yangsheng Yu, Kaihong Su, Cortney E. Heim, Tammy Kielian, Colm Morrissey, Jeremy S Frieling, Leah M. Cook

Journal Articles: Pathology and Microbiology

Bone metastatic prostate cancer (BM-PCa) significantly reduces overall patient survival and is currently incurable. Current standard immunotherapy showed promising results for PCa patients with metastatic, but less advanced, disease (i.e., fewer than 20 bone lesions) suggesting that PCa growth in bone contributes to response to immunotherapy. We found that: (1) PCa stimulates recruitment of neutrophils, the most abundant immune cell in bone, and (2) that neutrophils heavily infiltrate regions of prostate tumor in bone of BM-PCa patients. Based on these findings, we examined the impact of direct neutrophil-prostate cancer interactions on prostate cancer growth. Bone marrow neutrophils directly induced apoptosis …

Monocyte Metabolic Reprogramming Promotes Pro-Inflammatory Activity And Staphylococcus Aureus Biofilm Clearance, Kelsey J. Yamada, Cortney E. Heim, Xinyuan Xi, Kuldeep S. Attri, Dezhen Wang, Wenting Zhang, Pankaj K. Singh, Tatiana K. Bronich, Tammy Kielian

Journal Articles: Pathology and Microbiology

Biofilm-associated prosthetic joint infections (PJIs) cause significant morbidity due to their recalcitrance to immune-mediated clearance and antibiotics, with Staphylococcus aureus (S. aureus) among the most prevalent pathogens. We previously demonstrated that S. aureus biofilm-associated monocytes are polarized to an anti-inflammatory phenotype and the adoptive transfer of pro-inflammatory macrophages attenuated biofilm burden, highlighting the critical role of monocyte/macrophage inflammatory status in dictating biofilm persistence. The inflammatory properties of leukocytes are linked to their metabolic state, and here we demonstrate that biofilm-associated monocytes exhibit a metabolic bias favoring oxidative phosphorylation (OxPhos) and less aerobic glycolysis to facilitate their anti-inflammatory activity and biofilm …

Long-Term Negative Emotional Outcomes Of Warzone Tbi, Jennifer J. Vasterling, Mihaela Aslan, Susan P. Proctor, John Ko, Xenia Leviyah, John Concato

United States Food and Drug Administration: Publications

Objective: Many veterans of the Iraq and Afghanistan Wars have experienced traumatic brain injury (TBI). Although prior work has examined associations between TBI and development of psychi- atric syndromes, less is known about associations between TBI and component emotions constituting these syndromes, especially in the long term. The purpose of this study was to examine the long-term emotional consequences of deployment-related TBI.

Methods: As part of VA Cooperative Studies Program #566, we assessed a sample of n1⁄4456US Army soldiers prior to an index deployment to Iraq, and again an average of 8.3 years (SD1⁄42.4years) after their deployment for a long-term …

Gxd's Rna-Seq And Microarray Experiment Search: Using Curated Metadata To Reliably Find Mouse Expression Studies Of Interest., Constance M. Smith, James W Godwin, Richard M. Baldarelli, Jonathan S Beal, Olin Blodgett, Sharon C Giannatto, Joel E Richardson, Martin Ringwald

Faculty Research 2020

The Gene Expression Database (GXD), an extensive community resource of curated expression information for the mouse, has developed an RNA-Seq and Microarray Experiment Search (http://www.informatics.jax.org/gxd/htexp_index). This tool allows users to quickly and reliably find specific experiments in ArrayExpress and the Gene Expression Omnibus (GEO) that study endogenous gene expression in wild-type and mutant mice. Standardized metadata annotations, curated by GXD, allow users to specify the anatomical structure, developmental stage, mutated gene, strain and sex of samples of interest, as well as the study type and key parameters of the experiment. These searches, powered by controlled vocabularies and ontologies, can be …

Integrating Image Caption Information Into Biomedical Document Classification In Support Of Biocuration., Xiangying Jiang, Pengyuan Li, James A. Kadin, Judith A. Blake, Martin Ringwald, Hagit Shatkay

Faculty Research 2020

Gathering information from the scientific literature is essential for biomedical research, as much knowledge is conveyed through publications. However, the large and rapidly increasing publication rate makes it impractical for researchers to quickly identify all and only those documents related to their interest. As such, automated biomedical document classification attracts much interest. Such classification is critical in the curation of biological databases, because biocurators must scan through a vast number of articles to identify pertinent information within documents most relevant to the database. This is a slow, labor-intensive process that can benefit from effective automation.

We present a document classification …

Proceedings Of The Comprehensive Oncology Network Evaluating Rare Cns Tumors (Nci-Connect) Oligodendroglioma Workshop., Marta Penas-Prado, Jing Wu, Daniel P Cahill, Daniel J Brat, Joseph F Costello, Paul G Kluetz, J Gregory Cairncross, Martin Van Den Bent, Roel G W Verhaak, Orwa Aboud, Peter Burger, Susan M Chang, Christine Cordova, Raymond Y Huang, Lindsay S Rowe, Martin J B Taphoorn, Mark R Gilbert, Terri S Armstrong, Nci-Connect Oligodendr0glioma Worhshop

Faculty Research 2020

Background: Oligodendroglioma is a rare primary central nervous system (CNS) tumor with highly variable outcome and for which therapy is usually not curative. At present, little is known regarding the pathways involved with progression of oligodendrogliomas or optimal biomarkers for stratifying risk. Developing new therapies for this rare cancer is especially challenging. To overcome these challenges, the neuro-oncology community must be particularly innovative, seeking multi-institutional and international collaborations, and establishing partnerships with patients and advocacy groups thereby ensuring that each patient enrolled in a study is as informative as possible.

Methods: The mission of the National Cancer Institute's NCI-CONNECT program …

Speech Language Pathology Graduate Handbook - 2019-2020, Department Of Audiology And Speech-Language Pathology, East Tennessee State University

Speech-Language Pathology Handbooks

No abstract provided.

Understanding Costs Of Healthcare: Patient Perspectives And Beyond, Edwin Yirong Chan

Yale Medicine Thesis Digital Library

Introduction: Healthcare spending in the US is among the highest in the world and continues to grow year-over-year despite outcomes comparable to or worse than other nations. This spending has translated to extensive patient burden and high out-of-pocket costs for many individuals. Despite high costs to both systems and individuals, patients continue to pursue expensive care options such as emergency department care over other appropriate alternatives. Here, we assess patient understanding of emergency room costs and influences on their decisions to pursue emergency department care.

Methods: Adult patients presenting to the emergency department for conditions not meriting hospital admission or …

Human Amniotic Membrane Improves Healing In A Chronic, Massive Rotator Cuff Repair Model, Maarouf Saad

Yale Medicine Thesis Digital Library

Rotator cuff tendon heals by fibrovascular scar that is weaker than native tissue leading to repairs that are prone to failure. To investigate the utility of an amniotic-membrane-derived human allograft in improving tendon-bone healing and skeletal muscle architecture, a rotator cuff repair model in Sprague-Dawley rats was established, tendon biomechanical testing, single muscle fiber biomechanical testing, microcomputed tomography analysis, tendon and muscle histological analysis, and gene expression analysis were performed. Our findings demonstrated single muscle-fibers with larger cross-sectional area and greater maximum isometric and specific force in the augmented experimental repair (ER) group. Additionally, microcomputed tomography revealed a larger volume …

Coronary Revascularization Options For Females: A Meta-Analysis Of Randomized Controlled Trials, Tayyab Hussain Shah

Yale Medicine Thesis Digital Library

The totality of evidence for revascularization decisions between coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) for the treatment of multivessel coronary artery disease comes from predominantly male patients. Although societal guidelines do not provide sex specific recommendations, growing evidence suggests that revascularization outcomes may not be consistent between sexes. This study evaluates outcomes of CABG versus PCI in female patients with multivessel disease (MVD) and/or left main disease (LMD). We conducted a systematic search to identify randomized controlled trials (RCTs) comparing the long-term outcomes after PCI versus CABG in MVD and/or LMD. We extracted female specific data …

Characterization Of Temperature Curves In The Intensive Care Unit, Patricia Lourdes Valda Toro

Yale Medicine Thesis Digital Library

Fevers are extremely common in hospitalized patients, particularly in those admitted to the intensive care unit (ICU). Up to 50% of fevers in the ICU are non-infectious in origin. Yet, the development of a fever commonly prompts extensive, costly and invasive infectious workups. Patients with persistent fevers are usually treated with antimicrobials long after infectious workups prove unrevealing. While this is viewed as a ‘safe’ approach, inappropriate antibiotic use has shown to be harmful to patients – even effecting an increase in mortality – in addition to contributing to the spread of antibiotic resistance. The purpose of this study is …

A Systematic Literature Review Of Video-Based Interventions To Improve Integrated Competitive Employment Skills Among Youth And Adults With Autism Spectrum Disorder, Vidya D. Munandar, Mary E. Morningstar, Sarah R. Carlson

Special Education Faculty Publications and Presentations

BACKGROUND:

People with Autism Spectrum Disorder (ASD) have lower employment rates than their peers without disabilities or other disabilities. Clear evidence exists regarding video-based interventions (VBIs) for improving task performance and social communication skills for students with ASD. However, such interventions have rarely been applied in integrated employment settings.

OBJECTIVE:

This systematic literature review aims to examine the utilization and efficacy of video-based interventions in improving the skills required to secure and maintain a job for youth and adults with ASD.

METHODS:

A systematic literature review was conducted on peer-reviewed articles on VBIs and ASD from electronic databases (n.d. –2019), …

Strengthening Sideline Decisions About Concussions In Youth Sports (Strides): A Mixed Methods Approach, Ann Guernon

Graduate Research Theses & Dissertations

Background: Sport-related concussion in youth is a serious public health concern, and coaches of youth sports are frequently tasked with the role of primary decision maker about potential concussion during athletic activities.

Objective: To explore factors that influence coach decision-making about concussion in the moments during athletic activity that an injury may occur.

Methods: An exploratory sequential mixed methods study was conducted to identify coach-reported factors that influence decision-making about potential concussion and develop tools to evaluate prevention and management strategies that support coach decision-making during athletic activities. The study involved three phases: (1) semi-structured interviews with 16 coaches of …

Vitamin D Levels In Relation To Low Back Pain During Adolescence, Abdullah Al-Taiar, Abdur Rahman, Lemia Shaban, Anwar H. Albaloul, Sean Banaee, Muge Akpinar-Elci

Community & Environmental Health Faculty Publications

This study aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D) level and low back pain (LBP) among adolescents while adjusting for potential confounders pertinent to this age group including the weight of school bags, BMI and physical activity. A cross-sectional study was conducted on 760 randomly selected adolescents in middle schools. Data on LBP and the risk factors for LBP were collected from parents by a self-administered questionnaire and from adolescents by face-to-face interview. Blood samples were tested in an accredited laboratory; and 25(OH)D was measured using liquid chromatography-tandem MS. The lifetime prevalence and the 6-month prevalence of LBP …

Analysis Of Personality, Suicide, And Self‐Injury In Emerging Adulthood, Amanda C. La Guardia, Robert J. Cramer, Claire N. Bryson, Kelly Emelianchik-Key

Community & Environmental Health Faculty Publications

Nonsuicidal self‐injury (NSSI) is a maladaptive coping strategy that is of significant clinical concern for behavioral health professionals in college settings. Relationships between NSSI, acquired capability for suicide, interpersonal cognitions, and five‐factor model personality traits were assessed in a survey‐based study that included 192 young adults in a college setting. Results indicated that those with an affirmative suicide attempt history, greater acquired capability for suicide, and elevated neuroticism had an increased likelihood of lifetime NSSI.

Quality Of Life Of Adults With Chronic Spinal Cord Injury In Mainland China: A Cross-Sectional Study, Fengshui Chang, Haixia Xie, Qi Zhang, Mei Sun, Yuhui Yang, Gang Chen, Huifang Wang, Chengyue Li, Jun Lu

Community & Environmental Health Faculty Publications

Objective: To evaluate the quality of life of patients with chronic spinal cord injury in mainland China.

Design: Cross-sectional study. Subjects: A total of 247 adults ≥ 1 year post-SCI in mainland China.

Methods: The World Health Organization (WHO) Quality of Life Scale Brief Version (WHOQOL-BREF) and the add-on modules on disability-related QoL (WHOQOL-DIS) were used to assess quality of life. Anxiety/depression was measured using the Zung Self-Rating Anxiety/Depression Scale. Quality of life was compared with that of reference populations from China, Korea, the international field trial (23 countries). Multivariate linear regression was conducted to determine the factors that might …

Strategies For Safe And Effective Treatment Of Patients With Alzheimer Disease, Jafar Alabdullah, Ahmed Almuntashiri

Community & Environmental Health Faculty Publications

Alzheimer disease is a progressive neurodegenerative disorder that causes cognition impairment and memory loss, affecting activities in daily living. In the United States, an estimated 4.5 million people have AD and this figure is expected to reach 14 million by 2050. Because patients with AD experience a deterioration of their mental functions, patients need more help with their activities of daily living, including oral hygiene, as their AD progresses. Studies have found that individuals with AD often experience poor oral health. As advanced age is a risk factor for AD and the number of older adults in the US continues …

Factors Associated With Tobacco Smoking Among Saudi College Students: A Systematic Review, Saad A. Alotaibi, Praveen K. Durgampudi

Community & Environmental Health Faculty Publications

INTRODUCTION There has been an increase in tobacco smoking among Saudi college students in recent years. However, no study has examined, with a systematic approach, the extent to which specific factors are associated with tobacco smoking among this population.

METHODS PubMed, ProQuest, CINAHL, and Web of Science were utilized to retrieve studies addressing risk factors associated with tobacco smoking among Saudi college students between 2010 and 2019. After confirming their eligibility criteria, studies were imported to the NVivo software for data collection and synthesis. All included articles were critically appraised, based on a modified STROBE.

RESULTS Twenty-one out of 300 …

Prenatal Perception Of Wic Breastfeeding Recommendation Affects First Month Postpartum Breastfeeding Outcomes, Qi Zhang, Lamichhane Rajan, Joanne Guthrie

Community & Environmental Health Faculty Publications

No abstract provided.

Association Between Usage Of An App To Redeem Prescribed Food Benefits And Redemption Behaviors Among The Special Supplemental Nutrition Program For Women, Infants, And Children Participants: Cross-Sectional Study, Qi Zhang, Junzhou Zhang, Kayoung Park, Chuanyi Tang

Community & Environmental Health Faculty Publications

BACKGROUND: The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) is one of the most important food assistance programs in the United States, serving 6.4 million low-income, eligible women, infants, and children under 5 years of age in 2019. In the program, participants are prescribed a list of food benefits, which can be redeemed in WIC-authorized stores. However, there are multiple behavioral barriers in the program and the stores that prevent participants from redeeming the benefits fully.

OBJECTIVE: This study aims to examine the relationship between the use of a widely used mobile phone app, WICShopper, and the …

Ua94/6/1 Covid-19 Diary, Missy Thomas

Student/Alumni Personal Papers

COVID-19 diary submitted to WKU Archives by student Missy Thomas for fall 2020 semester.

Exploratory Study Of The Lived Experiences Of Adoptees In The Caribbean, Kelley T. Knowles

Department of Family Therapy Dissertations and Applied Clinical Projects

This qualitative research study offers exploration into Caribbean adoptee experiences related to their adoptive parent-child relationships. Existing studies focus on adoptive parent perspectives. Few accounts focus on Caribbean adoptees' experiences with adoption (Caughman, 2007). The existing research serves a purpose by helping adopted parents discuss adoption with adoptees. However, this approach does not include thevoice of the adoptee and fails to encompass the totality of adoptee lived experiences. The research does not focus on the amplification of the adoptees' voice, which in turn, neglects the adoptees' role inunderstanding their family processes. Therefore, it is pertinent to include lived experiences of …

White Marriage And Family Therapy Students’ Experiences In Diversity Courses: An Interpretative Phenomenological Analysis, Porshia Cunningham

Department of Family Therapy Dissertations and Applied Clinical Projects

American minority racial groups are on the rise and the majority racial group (White) will decrease in size (Vespa, Medina, & Armstrong, 2018). The U.S. population is becoming progressively diverse and projections indicate that by 2050, the elderly population will be 42% minority for the first time in history (U.S. Census Bureau, 2002). Racial minority experiences and needs are uniquely influenced by race due to systematic structures historically constructed in the United States (Cole, 2019; Sue, 2019). For many marriage and family therapy (MFT) students, particularly White students, the culture and diversity course is the primary mechanism for exposure to …

Can The Fut 2 Gene Variant Have An Effect On The Body Weight Of Patients Undergoing Bariatric Surgery? - Preliminary, Exploratory Study, Natalia Komorniak, Alexandra Martynova-Van Kley, Armen Nalian, Wiktoria Wardziukiewicz, Karolina Skoniecznaa-Zydecka, Daniel Styburski, Joanna Palma, Bartosz Kowalewski, Krzysztof Kaseja, Ewa Stachowska

Faculty Publications

Background: The FUT2 gene (Se gene) encoding the enzyme α-1,2-L-fucosyltransferase 2 seems to have a significant effect on the number and type of bacteria colonizing the intestines. Methods: In a group of 19 patients after bariatric surgery, the polymorphism (rs601338) of FUT2 gene was analyzed in combination with body mass reduction, intestinal microbiome (16S RNA sequencing), and short chain fatty acids (SCFA) measurements in stools. Results: Among the secretors (Se/Se polymorphism of the FUT2 gene rs601338, carriers of GG variant), correlations between waist-hip ratio (WHR) and propionate content and an increase in Prevotella, Escherichia, Shigella, and Bacteroides were observed. On …

Current Smoking With Or Without Chronic Bronchitis Is Independently Associated With Goblet Cell Hyperplasia In Healthy Smokers And Copd Subjects, Victor Kim, Stephanie Jeong, Huaqing Zhao, Mehmet Kesimer, Richard C. Boucher, J. Michael Wells, Stephanie A. Christenson, Meilan K. Han, Mark Dransfield, Robert Paine, Christopher B. Cooper, Igor Barjaktarevic, Russell Bowler, Jeffrey L. Curtis, Robert J. Kaner, Sarah L. O'Beirne, Wanda K. O'Neal, Stephen I. Rennard, Fernando J. Martinez, Prescott G. Woodruff

Journal Articles: Pulmonary & Critical Care Med

COPD, chronic bronchitis (CB) and active smoking have all been associated with goblet cell hyperplasia (GCH) in small studies. Active smoking is strongly associated with CB, but there is a disconnect between CB clinical symptoms and pathology. Chronic cough and sputum production poorly correlate with the presence of GCH or COPD. We hypothesized that the primary determinant of GCH in ever smokers with or without airflow obstruction is active smoking. Goblet Cell Density (GCD) was measured in 71 current or former smokers [32 subjects without COPD and 39 COPD subjects]. Endobronchial mucosal biopsies were stained with Periodic Acid Schiff-Alcian Blue, …

Co-Morbidity Patterns Identified Using Latent Class Analysis Of Medications Predict All-Cause Mortality Independent Of Other Known Risk Factors: The Copdgene® Study, Yisha Li, Margaret Ragland, Erin Austin, Kendra Young, Katherine Pratte, John E. Hokanson, Terri H Beaty, Elizabeth A. Regan, Stephen I. Rennard, Christina Wern, Michael R. Jacobs, Ruth Tal-Singer, Barry J. Make, Gregory L. Kinney, Copdgene Investigators

Journal Articles: Pulmonary & Critical Care Med

PURPOSE: Medication patterns include all medications in an individual's clinical profile. We aimed to identify chronic co-morbidity treatment patterns through medication use among COPDGene participants and determine whether these patterns were associated with mortality, acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and quality of life.

MATERIALS AND METHODS: Participants analyzed here completed Phase 1 (P1) and/or Phase 2 (P2) of COPDGene. Latent class analysis (LCA) was used to identify medication patterns and assign individuals into unobserved LCA classes. Mortality, AECOPD, and the St. George's Respiratory Questionnaire (SGRQ) health status were compared in different LCA classes through survival analysis, logistic …

Critical Appraisal Institute For Librarians (Caifl): Lessons From The Inaugural Class, Marie Ascher, Amy Blevins, Sarah Cantrell, Deborah A. Crooke, Diana Delgado, Sarah Jewell, Joseph Nicholson, Rachel Pinotti, Abe Wheeler

NYMC Faculty Posters

CAIFL aims to enhance critical appraisal institute skills in health sciences. Many health sciences librarians. Provide evidence based medicine (EBM) training at their home institutions, mostly limited to teaching about asking and acquiring; with only a rudimentary coverage of critical appraisal of clinical information. The goal is to enhance the abilities of health sciences librarians to take EBM training to the next level; and to enhance confidence and comfort of librarians in the realm of critical appraisal.