Medicine and Health Sciences Commons^™

Development Of Abuse Deterrent Formulations Using Hot Melt Extrusion, Pavan Kumar Nukala

Theses and Dissertations

In recent years prescription drug diversion, misuse, abuse represent a growing problem for the United States. Oral ingestion, snorting, injection are most commonly employed routes of abuse. To circumvent this problem hot melt extrusion (HME) was employed to prepare abuse deterrent formulation (ADF). Abuse Deterrent Immediate Release Egg-Shaped Tablet Using 3D Printing Technology: Quality by Design to Optimize Drug Release and Extraction. In current work, we developed egg-shaped tablet (egglet) using fused deposition modeling (FDM) 3D printing. Drug-loaded polymeric filaments (1.5 mm) were prepared using HME followed by printing into egglets of different sizes and infill densities. Based on printability, …

An Evaluation Of The Advance Directives-Live Action Simulation Training (Ad-Last) Program, Alexandra Rosa Spinelli

Theses and Dissertations

Advance Care Planning (ACP) is a process that captures a patient’s wishes in the case of future circumstances in which they are unable to express them. Studies show that less than one third of the general population has completed some type of formal Advance Directive (AD). There are barriers to completing ADs, and these barriers operate on multiple levels, including, patient, provider and institutional. To improve providers’ capacity to help patients complete ACP, and overcome these barriers, a provider-focused intervention was conducted. The current study is an analysis of archival data collected from the Advance Directives-Live Action Simulation Training (AD-LAST) …

Characterization Of A Speciese Adenovirus Vector As A Zika Virus Vaccine, Brianna L. Bullard, Brigette N. Corder, David N. Gordon, Theodore C. Pierson, Eric A. Weaver

Nebraska Center for Virology: Faculty Publications

The development of a safe and efficacious Zika virus (ZIKV) vaccine remains a global health priority. In our previous work, we developed an Adenovirus vectored ZIKV vaccine using a low-seroprevalent human Adenovirus type 4 (Ad4-prM-E) and compared it to an Ad5 vector (Ad5-prM-E). We found that vaccination with Ad4-prM-E leads to the development of a strong anti-ZIKV T-cell response without eliciting significant anti-ZIKV antibodies, while vaccination with Ad5-prM-E leads to the development of both anti-ZIKV antibody and T-cell responses in C57BL/6 mice. However, both vectors conferred protection against ZIKV infection in a lethal challenge model. Here we continued to characterize …

Severe Food Restriction Activates The Central Renin Angiotensin System, Aline Maria De Souza, Andrea Linares, Robert C. Speth, Glenda V. Campos, Hong Ji, Deoclécio Chianca, Kathryn Sandberg, Rodrigo C. De Menezes

HPD Articles

We previously showed that 2 weeks of a severe food restricted (sFR) diet (40% of the caloric intake of the control (CT) diet) up-regulated the circulating renin angiotensin (Ang) system (RAS) in female Fischer rats, most likely as a result of the fall in plasma volume. In this study, we investigated the role of the central RAS in the mean arterial pressure (MAP) and heart rate (HR) dysregulation associated with sFR. Although sFR reduced basal mean MAP and HR, the magnitude of the pressor response to intracerebroventricular (icv) microinjection of Ang-[1-8] was not affected; however, HR was 57 ± 13 …

Calcium Carbonate, Kristina Fritz, Katherine Taylor, Mayur S. Parmar

HPD Articles

No abstract provided.

Famciclovir, Jennifer R. Semaan, Mayur S. Parmar

HPD Articles

No abstract provided.

Doxycycline Hyclate, Reema S. Patel, Mayur S. Parmar

HPD Articles

No abstract provided.

Pramipexole, Raman Singh, Mayur S. Parmar

HPD Articles

No abstract provided.

A Systemic Review And Meta-Analysis On The Antihypertensive Effect Of Aromatherapy Essential Oils, Mikyoung Lee, Ji-Ah Song, Mina Ahn, Ahra Jo, Jeongah Park, Wonjong Kim, Claudia M. Davis, Yeon Sook Kim, Myun-Haeng Hur

Nursing Faculty Publications

Purpose: This study is a systemic review of experimental results on the effects of aromatherapy on blood pressure.

Materials and Methods: Journal articles published to December, 2017, were retrieved from twelve databases. Randomized controlled trials in which were evaluated for changes in blood pressure following aromatherapy were selected. Risks of bias were assessed using the risk-of-bias (ROB) tool of the Cochrane Collaboration. Meta-analysis were dine using RevMan.

Results: Of the 2545 articles retrieved from the electronic databases, 580 duplicate articles and 1891 articles that were unrelated to the PICO (patient/problem, intervention, comparison, outcome) elements or did not satisfy the inclusion …

Statistical Learning Methods To Predict Activity Intensity From Body-Worn Accelerometers, Drew M. Lazar, Munni Begum, Monzur Murshed, Benjamin Nelson, Joshua M. Bock, Mary T. Imboden, Leonard Kaminsky, Alex Hk Montoye

Faculty Publications - Department of Kinesiology

 Physical activity, especially when performed at moderate or vigorous intensity, has short- and long-term health benefits, but measurement of free-living physical activity is challenging. Accelerometers are popular tools to assess physical activity, although accuracy of conventional accelerometer analysis methods is suboptimal. This study developed and tested statistical learning models for assessing activity intensity from body-worn accelerometers. Twenty-eight adults performed 10-21 activities of daily living in two visits while wearing four accelerometers (right hip, right ankle, both wrists). Accelerometer placement is of crucial practical concern and this paper addresses this issue. Boosting, bagging, random forest and decision tree models were …

Accuracy Of Nonexercise Prediction Equations For Assessing Longitudinal Changes To Cardiorespiratory Fitness In Apparently Healthy Adults: Ball St Cohort, James E. Peterman, Matthew P. Harber, Mary T. Imboden, Mitchell H. Whaley, Bradley S. Fleenor, Jonathan Myers, Ross Arena, Holmes Finch, Leonard A. Kaminsky

Faculty Publications - Department of Kinesiology

Background Repeated assessment of cardiorespiratory fitness (CRF) improves mortality risk predictions in apparently healthy adults. Accordingly, the American Heart Association suggests routine clinical assessment of CRF using, at a minimum, nonexercise prediction equations. However, the accuracy of nonexercise prediction equations over time is unknown. Therefore, we compared the ability of nonexercise prediction equations to detect changes in directly measured CRF. Methods and Results The sample included 987 apparently healthy adults from the BALL ST (Ball State Adult Fitness Longitudinal Lifestyle Study) cohort (33% women; average age, 43.1±10.4 years) who completed 2 cardiopulmonary exercise tests ≥3 months apart (3.2±5.4 years of …

Pedometer Feedback Interventions Increase Daily Physical Activity In Phase Iii Cardiac Rehabilitation Participants, Cemal Ozemek, Scott J. Strath, Katrina Riggin, Matthew P. Harber, Mary T. Imboden, Leonard A. Kaminsky

Faculty Publications - Department of Kinesiology

Purpose: To determine the effects of individually tailored interventions designed to increase physical activity (PA) in cardiac patients.

Methods: A total of 99 (77 men and 22 women, 61.5 ± 10.7 yr) patients entering a phase III cardiac rehabilitation program completed a 12-wk PA intervention. Patients were randomized to usual care (UC, time-based recommendation), pedometer feedback (PF), newsletter-based motivational messaging (MM), or PF + MM. Both PF groups were given a goal of increasing steps/d by 10% of individual baseline value each week. If the goal for the week was not reached, the same goal was used for the next …

Normalizing Cardiorespiratory Fitness To Fat-Free Mass Improves Mortality Risk Prediction In Overweight Adults From The Ball St Cohort: 2361 Board #280 May 28 3:00 Pm - 4:30 Pm, Mary T. Imboden, Leonard A. Kaminsky, James E. Peterman, Haylee L. Hutzler, Mitchell H. Whaley, Bradley S. Fleenor, Matthew P. Harber

Faculty Publications - Department of Kinesiology

Cardiorespiratory fitness(CRF) is a significant predictor of mortality outcomes in various populations, including overweight and obese adults. However, CRF is commonly expressed normalized to total body weight (VO_2peakTBW) which may weaken the relationship in obese adults as fat-free mass (FFM) is directly related to CRF, and increased body fat is associated with lower CRF in adults. Therefore, this study aimed to assess the relationship between CRF normalized for FFM(VO_2peakFFM) and all-cause mortality, as well as compare the predictive ability of VO_2peakFFM and VO_2peakTBW in a cohort of self-referred overweight and obese adults.

The Impact Of Lifestyle Medicine On Nonalcoholic Fatty Liver Disease, Kelli L. Noble

DNP Research Projects

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. The main risk factor for the development of NAFLD is metabolic syndrome. Women are at greatest risk, typically in their 5th to 6th decade of life. The more aggressive form of NAFLD is nonalcoholic steatohepatitis (NASH) which is characterized by inflammation associated with NAFLD. NASH has the greatest tendency to progress into cirrhosis. However, lifestyle intervention has been shown to effectively treat, and even reverse NAFLD. The purpose of this quantitative, quasi-experimental study was to lend additional research and demonstrate improvement in NAFLD through lifestyle intervention with 1) …

Four-Week Ankle-Rehabilitation Programs In Adolescent Athletes With Chronic Ankle Instability, M. Spencer Cain, Rebecca Ban, Yu-Ping Chen, Mark Geil, Benjamin Goerger, Shelley Linens

Faculty Articles

Context: Researchers have shown that rehabilitation programs incorporating resistance-band and balance-board exercises are effective for improving clinical measures of function and patient-reported outcomes in individuals with chronic ankle instability (CAI). However, whether combining the 2 exercises increases improvement is unknown. Objective: To determine the effectiveness of 3 rehabilitation programs on clinical measures of balance and self-reported function in adolescent patients with CAI. Design: Randomized controlled clinical trial (Trail Registration Number: ClinicalTrails.gov: NCT03447652). Setting: High school athletic training facilities.Patients or Other Participants: Forty-three patients with CAI (age ¼ 16.37 6 1.00 years, height ¼ 171.75 6 12.05 cm, mass ¼ 69.38 …

Exploring The Lived Experiences Of Adults Who Have Experienced A Parental Divorce: Identifying Collaborative Divorce Aspects As They Adjusted To Adulthood, Arlene Brown

Department of Family Therapy Dissertations and Applied Clinical Projects

Divorce itself is a traumatic experience for everyone involved, especially the children. Studies have been conducted to focus on the effects on children, and ways to help with adjustment. Furthermore, researchers have delved into the long-term effects parental divorce has on children. Collaborative divorce is an approach to divorce that utilizes a specially trained team of family law, financial, and mental health professionals (MHPs) working together with couples to resolve issues related to the dissolution of their marriage, the co-parenting of their children, and the restructuring of their lives–without involving the court system. Some of the aspects of a collaborative …

Comparison Of Low Carbohydrate Diets On Renal And Glucose Function In Subjects With Type 2 Diabetes: A Systematic Review And Meta-Analysis, Garrett A. Couch

Honors Undergraduate Theses

Background - Type 2 Diabetes Mellitus (T2DM) is a growing crisis that can lead to more problems if left untreated. One of these problems includes diabetic nephropathy or Chronic Kidney Disease (CKD). While there have been many advances in the field of treating CKD with medication, there are currently no medications with the capability of stopping the progression of or reversing diabetic nephropathy; however, recent studies have shown that diabetic nephropathy can be stopped and even reversed through dietary interventions. One of these studies went through the effects of a low protein diet on diabetic nephropathy and found very promising …

The Effects Of Modifiable And Non-Modifiable Risk Factors On The Severity Of Gastroparesis-Like Symptoms, Jonathon B. Nelson

Honors Undergraduate Theses

Gastroparesis (GP) is a clinical disorder recognized by measured delayed gastric emptying without mechanical obstruction, in addition to symptoms such as nausea, vomiting, chronic abdominal pain, heartburn, early satiety upon eating a regular-sized meal, and exaggerated postprandial fullness. While GP is considered a clinically rare disorder, there is much suspicion that a much larger number of patients experience GP-like symptoms without an official diagnosis. Furthermore, little work has been done to identify the causes and exacerbations of this gastrointestinal (GI) distress in the young adult population. This study's primary goal was to establish a relationship between modifiable and non-modifiable risk …

Evaluation Of Remote-Based Learning Of A Nutrition Program For Adolescents With Autism Spectrum Disorder: A Covid-19 Pilot Study, Riley H. Shurack

Honors Undergraduate Theses

Introduction: Adolescents with Autism Spectrum Disorder (ASD) demonstrate poor health-related behaviors, such as nutrition, compared to their typically developed (TD) counterparts. With the occurrence of the COVID-19 pandemic and mandatory stay-at-home orders, such health-related behaviors may be complicated and there is a need to focus on feasibility and acceptability of in-person and remote-based nutrition programs.

Methods: Eleven high school students with ASD were recruited to participate in a modified nutrition program utilizing Zoom software during COVID-19. The duration was once a week for four weeks, and concepts reviewed included shopping for healthy food on a budget, introducing non-perishable …

Risk Factors For Liposomal Bupivacaine Resistance After Total Hip Or Knee Arthroplasties: A Retrospective Observational Cohort In 237 Patients, Scott Buzin, Arianna L. Gianakos, Deborah Li, Anthony Viola, Sherif Elkattawy, David M. Keller, Richard S. Yoon, Frank A. Liporace

Orthopedic Surgery Resident Research

Purpose: Liposomal bupivacaine demonstrated promise decreasing postoperative pain in total hip and total knee arthroplasty (THA/TKA). Some randomized trials have shown non-superior results; however, confounding variables were not accounted for in such analyses. This study attempts to determine risk factors associated with failure of pain management in patients receiving liposomal bupivacaine.

Methods: Postoperative pain scores were collected following primary or revision arthroplasties between January 2016 and December 2017. Retrospective analysis of institutional total joint quality and outcomes registry was screened and patients undergoing primary or revision arthroplasties who completed a multi-modal pain management including liposomal bupivacaine were included in the …

Gastrointestinal Stromal Tumor (Gist) In Long Standing Crohn’S Disease On Anti-Tnf Therapy, David Mendel, Taseen Syed, H R. Lippman, Brian Davis

Graduate Medical Education (GME) Resident and Fellow Research Day Posters

Introduction

Patients suffering from inflammatory bowel disease (IBD) are at increased risk for developing cancer. Adenocarcinomas are the most commonly observed tumors of the gastrointestinal tract whereas data on gastrointestinal stromal tumor (GIST) in IBD patients is limited. GIST is a neoplasm that originates from the interstitial cells of Cajal in the smooth muscle layers of the gastrointestinal tract. [1] The association between GIST and Crohn’s disease (CD) is debated, as the tumor inconsistently present in areas of inflammatory activity. We report an interesting case of CD maintained on Infliximab, who presented with a flare that revealed GIST in the …

Full Issue-- Volume 3 Issue 1, 2020, Issue 1 Volume 3

Pursue: Undergraduate Research Journal

PURSUE: Undergraduate Research Journal

Volume 3 Issue 1, 2020

Article 1 - Harvesting Electrical Energy Produced by Electrogenic Bacteria in Microbial Fuel Cells

Article 2 – The Effects of Fertilizer Rate on the Growth of Egyptian Spinach in a Greenhouse

Article 3 – Exploring the Association Between Nutrition and Mental Health in Adolescence: A Systematic Literature Review

Article 4— Biological Pathways Associated with Wild and Domestic Animals

Exploring The Association Between Nutrition And Mental Health In Adolescence: A Systematic Literature Review, Asia Walker, Andrea Mcdonald, Angela Branch-Vital

Pursue: Undergraduate Research Journal

Introduction: Throughout life, proper nutrition is important to the brain as it affects cognition and intellectual development. Studies have shown that a lack of certain nutrients can affect the body’s ability to perform mentally and physically. Annually, 14% of children in the United States receive mental health illness diagnoses. However, the link between nutrition and mental health is not clear. The purpose of this systematic literature review on mental health and nutrition in adolescence is to identify any gaps that require future research efforts. Methods: The Elton Bryson Stephens Company ( EBSCO), ProQuest, and Journal Storage (JSTOR) databases were used …

Extraction And Analysis Of Data For Fragility Fracture Patients To Help Determine The Likelihood Of Follow-Up With A West Michigan Fragility Fracture Service, Michael Joseph Lamphere

Doctoral Dissertations

Fragility fractures and secondary fractures are a large physical, financial, and emotional drain on the individuals and families affected. Improving post fragility fracture care and increasing follow-up rates with specialty services, such as a fracture liaison service, may promote post-fracture recovery and help prevent future fractures. The purpose of this doctoral project was to increase and improve post osteoporotic fracture care by increasing appropriate referrals and follow-up care. Patient data was retrieved and analyzed on 60 fragility fracture patients referred to a local fracture liaison service. The analysis found that patient gender, fracture site, and history of a previous fracture …

Global Survey On Pancreatic Surgery During The Covid-19 Pandemic., A. Oba, T. F. Stoop, M. Löhr, T. Hackert, N. Zyromski, W. H. Nealon, M. Unno, R. D. Schulick, M. H. Al-Musawi, M. Del Chiaro, +6 Additional Authors

Journal Articles

OBJECTIVE:The aim of this study was to clarify the role of pancreatic surgery during the COVID-19 pandemic to optimize patients' and clinicians' safety and safeguard health care capacity. SUMMARY BACKGROUND DATA:The COVID-19 pandemic heavily impacts health care systems worldwide. Cancer patients appear to have an increased risk for adverse events when infected by COVID-19, but the inability to receive oncological care seems may be an even larger threat, particularly in case of pancreatic cancer. METHODS:An online survey was submitted to all members of seven international pancreatic associations and study groups, investigating the impact of the COVID-19 pandemic on pancreatic surgery …

Editorial: The Role Of Hmgb1 In Immunity, M. Son, B. Diamond, J. Shin

Journal Articles

No abstract provided.

Characterization Of Antibiotic Use And Culture Data In Covid-19 Pandemic Patients, Ashley Logan Pharmd, Stacy Clore Pharmd, Bcps, Alissa Keillor Pharmd

Parkview Pharmacy Department

Poster Presentation

2020 ASHP Midyear Clinical Meeting / Virtual / Poster # RP-609

Objective: The objective of this study was to identify the prevalence of bacterial, viral, or fungal coinfections and to describe the empiric antimicrobial regimens in patients with confirmed COVID-19.

Postoperative Vital Signs: Traditional Versus Evidence Based, Linda Otis Bsn, Rn

Nursing Active Studies

This study compares the current standard vital sign frequency in postoperative recovery patients to an investigator-designed vital sign algorithm, the Trax Algorithm. This tool guides nursing care based on assessments of the postoperative patient to determine appropriate vital sign frequency.

Infant Death Rates Between Different Medical Attendants, Zenab Saeed

Scholarship in Medicine - All Papers

The function of midwives in the context of maternal health is important, especially when understanding the role of midwives in a global context compared to in the United States. Globally, midwives have served as historically important members in the process of childbirth, but their role has experienced changes in response to increased medicalization over the years, especially in the United States.1 Based of their use and effectiveness in a global context, literature suggests that it may be beneficial for both the healthcare system, mothers, and infants to expand the role of midwives in the United States.2 The purpose of this …

Health Disparities Surrounding Air Quality And Asthma, Carolina B. Nadal Medina

Scholarship in Medicine - All Papers

Introduction: Asthma is a prevalent disease in the US in both children and adults. Studies in the past have found disparities in asthma prevalence among different races in the United States as well as between gender. Objective: Compare asthma prevalence among racial and ethnic groups in the us, as well as gender, in the United States in both children and adults in the years of 2011 and 2014. Additionally, to see if there is a correlation between air quality, measured in PM2.5mm, and asthma prevalence in different racial groups and genders in both children and adults. Methods: Asthma prevalence data …