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2020

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Articles 151 - 180 of 20666

Full-Text Articles in Medicine and Health Sciences

Protocol For A Trial Assessing The Impacts Of School-Based Wash Interventions On Children’S Health Literacy, Handwashing, And Nutrition Status In Low- And Middle-Income Countries, Stephanie O. Sangalang, Shelley Anne J. Medina, Zheina J. Ottong, Allen Lemuel G. Lemence, Donrey Totanes, John Cedrick Valencia, Patricia Andrea A. Singson, Mikaela Olaguera, Nelissa O. Prado, Roezel Mari Z. Ocaña, Rovin James F. Canja, Alfem John T. Benolirao, Shyrill Mae F. Mariano, Jergil Gyle Gavieres, Clarisse P. Aquino, Edison C. Latag, Maria Vianca Jasmin C. Anglo, Christian Borgemeister, Thoomas Kistemann Dec 2020

Protocol For A Trial Assessing The Impacts Of School-Based Wash Interventions On Children’S Health Literacy, Handwashing, And Nutrition Status In Low- And Middle-Income Countries, Stephanie O. Sangalang, Shelley Anne J. Medina, Zheina J. Ottong, Allen Lemuel G. Lemence, Donrey Totanes, John Cedrick Valencia, Patricia Andrea A. Singson, Mikaela Olaguera, Nelissa O. Prado, Roezel Mari Z. Ocaña, Rovin James F. Canja, Alfem John T. Benolirao, Shyrill Mae F. Mariano, Jergil Gyle Gavieres, Clarisse P. Aquino, Edison C. Latag, Maria Vianca Jasmin C. Anglo, Christian Borgemeister, Thoomas Kistemann

Development Studies Faculty Publications

Diarrhea, soil-transmitted helminth infection and malnutrition are leading causes of child mortality in low- and middle-income countries (LMICs). To reduce the prevalence of these diseases, effective interventions for adequate water, sanitation, and hygiene (WaSH) should be implemented. This paper describes the design of a cluster-randomized controlled trial that will compare the efficacy of four school-based WaSH interventions for improving children’s health literacy, handwashing, and nutrition. Interventions consisted of (1) WaSH policy reinforcement; (2) low-, medium-, or high-volume health education; (3) hygiene supplies; and (4) WaSH facilities (e.g., toilets, urinals, handwashing basins) improvements. We randomly allocated school clusters from the intervention …


The Meeting Point Of Neo-Sufism And School Counselors Competencies, Ridwan Ridwan, Anwar Sutoyo, Ali Mansur Dec 2020

The Meeting Point Of Neo-Sufism And School Counselors Competencies, Ridwan Ridwan, Anwar Sutoyo, Ali Mansur

Jurnal Kajian Bimbingan dan Konseling

Neo-sufism is the recent Sufi movement that actively develops society. Historically, sufism has brought forth arif billâh individuals who have great faith and devotion to Allah, excellent pedagogical competence, as well as social and professional skills. This study aims to construct the meeting point between neo-sufism character and school counselor competence. It was carried out using a qualitative approach with the Hermeneutic analysis from Paul Ricoeur. The data was obtained from documents and interviews. The results reveal the meeting point between neo-sufism character and four counselors competencies. Makrifatullah (depth comprehension of God) character is linear with pedagogical and personality competence. …


Students’ Academic Resilience Profiles Based On Gender And Cohort, Suciani Latif, Muhammad Amirullah Dec 2020

Students’ Academic Resilience Profiles Based On Gender And Cohort, Suciani Latif, Muhammad Amirullah

Jurnal Kajian Bimbingan dan Konseling

This study examined the differences in the students’ academic resilience based on gender and cohort. Participants were students of Department of Educational Psychology and Guidance, Faculty of Education, Universitas Negeri Makassar in the academic years of 2013, 2014, and 2015. They were comprised of 103 students, 77 females and 26 males. The instrument in this study was Academic Resilience Scale (ARS) adopted and modified from Martin and Marsh. Data were analyzed through Mann-Whitney statistical of non-parametric tests in order to measure the academic resilience level of gender difference and Kruskal Wallis to measure academic resilience of cohort difference. Results revealed …


The Health Effects Of Vitamin D And Probiotic Co-Supplementation: A Systematic Review Of Randomized Controlled Trials, Myriam Abboud, Rana Rizk, Fatme Al Anouti, Dimitrios Papandreou, Suzan Haidar, Nadine Mahboub Dec 2020

The Health Effects Of Vitamin D And Probiotic Co-Supplementation: A Systematic Review Of Randomized Controlled Trials, Myriam Abboud, Rana Rizk, Fatme Al Anouti, Dimitrios Papandreou, Suzan Haidar, Nadine Mahboub

All Works

Evidence of synergic health effects of co-supplementation with vitamin D and probiotics is emerging. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses PRISMA statement, scientific databases and the grey literature were searched, and a narrative review and risk of bias assessment were conducted. Seven randomized controlled trials were included, which had low risk of bias. Six studies were double-blind, and once single-blind, extended over 6-12 weeks, and included 50-105 participants. Conditions explored included schizophrenia, gestational diabetes, type 2 diabetes and coronary heart disease, polycystic ovarian syndrome, osteopenia, irritable bowel syndrome (IBS), and infantile colic. Supplementation frequency was daily …


Decomposing Differences In Coronavirus Disease 2019-Related Case-Fatality Rates Across Seventeen Nations, Ashley Wendell Kranjac, Dinko Kranjac Dec 2020

Decomposing Differences In Coronavirus Disease 2019-Related Case-Fatality Rates Across Seventeen Nations, Ashley Wendell Kranjac, Dinko Kranjac

Sociology Faculty Articles and Research

As of 1 November 2020, estimated case-fatality rates associated with coronavirus disease 2019 are not uniformly patterned across the world and differ substantially in magnitude. Given the global spatial heterogeneity in case-fatality rates, we applied the Blinder-Oaxaca regression decomposition technique to identify how putative sociodemographic, structural, and environmental sources influence variation in case-fatality rates. We show that compositional and associational differences in country-level risk factors explain a substantial proportion of the coronavirus disease 2019-related case-fatality rate gap across nations. Asian countries fair better vis-à-vis case-fatality rate differences mainly due to variation in returns to sociodemographic, structural, and environmental sources among …


Acupuncture And Its Effects On Chronic Pain, Pavan Patel, Michael Sabia, Jashen Patheja, Rohan Kapoor, Tiffany Mathias, Tameem Murtaza Dec 2020

Acupuncture And Its Effects On Chronic Pain, Pavan Patel, Michael Sabia, Jashen Patheja, Rohan Kapoor, Tiffany Mathias, Tameem Murtaza

Cooper Rowan Medical Journal

Abstract

Acupuncture is an complementary form of medicine that has relatively recently become a component of traditional Chinese medicine (TCM). It involves the application of thin needles at specific points throughout the body, although initially, general areas instead of points were used. There are estimated to be about 395 different points that can be utilized, and the technique behind using these points can vary widely between practitioners. In addition to acupuncture points, TCM is said to use meridians or pathways along with qi, or energy flows. In terms of acupunctures’ utility, it has been known to treat a variety of …


2020-12-29_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services Dec 2020

2020-12-29_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Hospitals. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.


2020-12-29_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services Dec 2020

2020-12-29_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services

Michigan COVID-19 Vaccine Data

The COVID Vaccine Dashboard page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/0,9753,7-406-98178_103214-547150--,00.html.

Data is updated Monday through Saturday. Previously reported numbers of administered vaccine doses may change as new data are received. A possible lag in reporting vaccine doses will result in increases in numbers previously reported.

This report is created by the Michigan Department of Health and Human Services Division of Immunization from data reported to the Michigan Care Improvement Registry (MCIR).

The dashboard contained the tabs Vaccines Shipped, Distribution Trend, Doses Administered, Doses by Vaccine, Doses Metrics, Enrolled Providers, and …


2020-12-29_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services Dec 2020

2020-12-29_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …


2020-12-29_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services Dec 2020

2020-12-29_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The data below represents a cumulative total of confirmed COVID-19 resident cases, cumulative total of suspected and confirmed resident deaths, cumulative total of confirmed COVID-19 staff cases, and cumulative total of suspected and confirmed staff deaths reported by SNFs in Michigan since January 1, 2020. Case numbers are provisional and may change …


An Assessment Of Knowledge, Attitude, And Practice Of The Kuantan Community On The Effects Of Monosaccharides On Cancer, Muhammad Alif Mazlan, Muhammad Kamil Che Hasan, Afzan Mat Yusof, Muhammad Lokman Md Isa Dec 2020

An Assessment Of Knowledge, Attitude, And Practice Of The Kuantan Community On The Effects Of Monosaccharides On Cancer, Muhammad Alif Mazlan, Muhammad Kamil Che Hasan, Afzan Mat Yusof, Muhammad Lokman Md Isa

Makara Journal of Health Research

Background: Cancer knowledge, attitude, and practice (KAP) levels of communities are essential to be assessed to enhance cancer educational programs. This study aimed to determine the KAP level of the Kuantan community on the effects of monosaccharides on cancer. The association between the sociodemographic data and KAP level of the community has also been evaluated.

Methods: A cross-sectional survey was performed among residents living in the Kuantan community. Only 303 of 380 responses were included in the data analysis using the chi-square test.

Results: The knowledge and practice levels were moderate, whereas the attitude was at a …


2020-12-29_Michigandaily_Covidmap, Michigan Department Of Health & Human Services Dec 2020

2020-12-29_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …


Red Panda: A Novel Method For Detecting Variants In Single-Cell Rna Sequencing, Adam Cornish, Shrabasti Roychoudhury, Krishna Sarma, Suravi Pramanik, Kishor Bhakat, A T. Dudley, Nitish K. Mishra, Chittibabu Guda Dec 2020

Red Panda: A Novel Method For Detecting Variants In Single-Cell Rna Sequencing, Adam Cornish, Shrabasti Roychoudhury, Krishna Sarma, Suravi Pramanik, Kishor Bhakat, A T. Dudley, Nitish K. Mishra, Chittibabu Guda

Journal Articles: Genetics, Cell Biology & Anatomy

BACKGROUND: Single-cell sequencing enables us to better understand genetic diseases, such as cancer or autoimmune disorders, which are often affected by changes in rare cells. Currently, no existing software is aimed at identifying single nucleotide variations or micro (1-50 bp) insertions and deletions in single-cell RNA sequencing (scRNA-seq) data. Generating high-quality variant data is vital to the study of the aforementioned diseases, among others.

RESULTS: In this study, we report the design and implementation of Red Panda, a novel method to accurately identify variants in scRNA-seq data. Variants were called on scRNA-seq data from human articular chondrocytes, mouse embryonic fibroblasts …


Filial Piety Expectations And Loneliness Among Older People In Kuantan, Pahang, Aniawanis Makhtar, Nor Hafizah Samsudin Dec 2020

Filial Piety Expectations And Loneliness Among Older People In Kuantan, Pahang, Aniawanis Makhtar, Nor Hafizah Samsudin

Makara Journal of Health Research

Background: Filial piety plays a vital role in combating loneliness among older people. Older adults have a high tendency to feel lonely when affection toward and from their children decreases. This study aimed to determine the association between filial piety expectations and loneliness among older people in Kuantan, Pahang.

Methods: A cross-sectional study was conducted on 198 older people in Kuantan, Pahang. Filial piety expectation and loneliness were measured by the Filial Piety Expectation Scale and UCLA (University of California, Los Angeles) Loneliness Scale questionnaire. The data were analyzed by using SPSS version 22.0.

Results: The results …


Factors Influencing Health Service Utilization Among The Elderly In Insein Township, Yangon Region, Sandar Min Min Hlaing, Naw Clara, Aye Nanda Han Dec 2020

Factors Influencing Health Service Utilization Among The Elderly In Insein Township, Yangon Region, Sandar Min Min Hlaing, Naw Clara, Aye Nanda Han

Makara Journal of Health Research

Background: With the increasing needs of the aging population and the increasing prevalence of non-communicable diseases, assessment of the equity and accessibility of health care among the elderly has become important.

Methods: A cross-sectional descriptive study was conducted from December 2018 to December 2019 among 225 elderly to describe the factors influencing health service utilization. Multistage sampling was applied, and structured questionnaire was used to interview the elderly. Chi-squared test and multiple logistic regression were performed in data analysis.

Results: The average age of the respondents was 71.7 ± 8.17 years old, and 68.4% of the respondents …


The Role Of Parents In Providing Sexuality Education To Their Children, Nur Azira Fideyah Binti Abdullah, Siti Mariam Muda, Norhasmah Mohd Zain, Siti Hazariah Abdul Hamid Dec 2020

The Role Of Parents In Providing Sexuality Education To Their Children, Nur Azira Fideyah Binti Abdullah, Siti Mariam Muda, Norhasmah Mohd Zain, Siti Hazariah Abdul Hamid

Makara Journal of Health Research

Background: Parents have an important role in delivering sexuality education to their children. However, Asian parents are reluctant to discuss sexual matters with their children owing to the sensitivity of the topic and their lack of sexual health knowledge. This study aimed to examine Malaysian parents’ knowledge, attitudes, and practices in providing sexuality education to their children.

Methods: A self-administered questionnaire was used to conduct this cross-sectional study featuring 200 Malaysian parents. Descriptive and univariate analyses were performed using Statistical Package for Social Study (SPSS) version 23.0.

Results: Among the majority (79.5%) of the parents having good …


Knowledge, Attitudes, And Practices Of Adolescents Regarding Sexuality And Reproductive Issues In The Cordillera Administrative Region Of The Philippines, Eddieson Pasay-An, Judith Odanee G. Magwilang, Petelyne P. Pangket Dec 2020

Knowledge, Attitudes, And Practices Of Adolescents Regarding Sexuality And Reproductive Issues In The Cordillera Administrative Region Of The Philippines, Eddieson Pasay-An, Judith Odanee G. Magwilang, Petelyne P. Pangket

Makara Journal of Health Research

Background: This study investigates the knowledge, attitudes, and practices (KAP) concerning reproductive health (RH) and sexuality among in- and out-of-school adolescents in the Cordillera Administrative Region (CAR), Philippines.

Methods: Using a quantitative, cross-sectional approach, this study examined 739 in- and out-of-school adolescents who were recruited through snowball and simple random sampling.

Results: Statistically significant differences were noted in the knowledge, attitudes, and practices regarding sexuality based on age. Age was associated with knowledge, attitudes, and practices concerning RH. Educational attainment toward sexuality also caused statistically significant changes in knowledge, attitudes, and practices. The KAP regarding sexuality and …


Dental Caries Among 12-Year-Old Children After Discontinuation Of Water Fluoridation In Pahang, Malaysia, Faizah Abdul Karim, Zamros Yuzadi Mohd Yusof, Nor Azlida Mohd Nor Dec 2020

Dental Caries Among 12-Year-Old Children After Discontinuation Of Water Fluoridation In Pahang, Malaysia, Faizah Abdul Karim, Zamros Yuzadi Mohd Yusof, Nor Azlida Mohd Nor

Makara Journal of Health Research

Background: Water fluoridation (WF) has been a national caries prevention program in Malaysia since 1972. However, between July 2012 and December 2013, WF was discontinued in Pahang. This study aimed to compare caries prevalence and mean caries experience among Malaysian children in WF and WF-ceased areas and determine its associated risk factors.

Methods: This cross-sectional study was conducted among 12-year-old schoolchildren in two Malaysian states: Pahang (WF-ceased) and Perak (WF-continued). Dental caries was examined using ICDAS criteria, and a questionnaire was used to collect relevant data. Associations between independent variables and dental caries were analyzed by simple logistic …


Psychosocial Impacts Of Fixed Orthodontic Treatment In Lahore, Pakistan, Hazik Bin Shahzad, Dalia Iftikhar, Noor Ul Huda, Nayha Enver, Faiza Awais, Shabbir Hussain Dec 2020

Psychosocial Impacts Of Fixed Orthodontic Treatment In Lahore, Pakistan, Hazik Bin Shahzad, Dalia Iftikhar, Noor Ul Huda, Nayha Enver, Faiza Awais, Shabbir Hussain

Makara Journal of Health Research

Background: The aim of this study is to assess psychosocial impacts on oral health-related quality of life between individuals currently undergoing orthodontic treatment and those who have completed treatment.

Methods: A total of 135 individuals were selected from the Orthodontic Department at Rashid Latif Dental Hospital, Lahore, Pakistan. Current and previous orthodontic treatments were recorded. A questionnaire on oral impacts on daily performance was used to assess functional, psychological, and social limitations.

Results: The most prevalent psychosocial impact was difficulty in smiling/laughing (26.6%). Logistic regression analysis showed that individuals currently undergoing orthodontic treatment are 2.9 times more …


Self-Assessment Tool For Evaluating Periodontal Conditions, Haslina Rani, Tuti Ningseh Mohd-Dom, Shahida Mohd-Said, Nur Azwani Johari Dec 2020

Self-Assessment Tool For Evaluating Periodontal Conditions, Haslina Rani, Tuti Ningseh Mohd-Dom, Shahida Mohd-Said, Nur Azwani Johari

Makara Journal of Health Research

Background: The global prevalence of periodontal disease is steadily rising. Early detection through the active screening of potential patients is important because periodontal disease leads to high disease, clinical, and economic burdens. The aim of this study is to develop a simple periodontal assessment tool for the Malay-speaking population; this tool is referred to in this work as MyGusi.

Methods: Translation and back-translation of a self-assessment tool containing 10 items related to periodontal health conditions and risk behaviors were conducted by three bilingual translators. Nine periodontists were selected to determine the content validity of the tool. After pre-testing …


Attitudes And Work Preferences Toward Older People Among Malay Undergraduate Nursing Students, Sharifah Munirah Syed Elias, Nor Faeziah Jaafar, Lee Siew Pien Dec 2020

Attitudes And Work Preferences Toward Older People Among Malay Undergraduate Nursing Students, Sharifah Munirah Syed Elias, Nor Faeziah Jaafar, Lee Siew Pien

Makara Journal of Health Research

Background: The aging population is increasing globally and requires a high demand for healthcare services in several countries. As a way of preparing future nurses in aged care, substantial incorporation of gerontology courses in the nursing program to meet future needs is required. The present study aimed to investigate the association between attitudes and work preferences toward older people among undergraduate nursing students.

Methods: A cross-sectional study was conducted involving 291 nursing students at a Malaysian public university. A set of questionnaires was used that comprised the following three parts: (1) Part A: Sociodemographic background, (2) Part B: …


When Working Out Makes You Sick To Your Stomach: What To Know About Exercise-Induced Nausea, Anne R. Crecelius Dec 2020

When Working Out Makes You Sick To Your Stomach: What To Know About Exercise-Induced Nausea, Anne R. Crecelius

Health and Sport Science Faculty Publications

You’re doing it! You’re working out, reaping all those benefits of exercise that have been drilled into your head.

So you’re pedaling your heart out or running like you’re escaping a zombie horde. You’re feeling accomplished, on cloud nine, until … your stomach starts to churn. You may even feel dizzy. Your feelings of accomplishment have turned to agony as you deal with a bout of nausea.

Exercise-induced nausea is quite common, as are exercise-induced gastrointestinal (GI) problems in general, affecting perhaps up to 90% of endurance athletes.

So why does this happen and, more important, how can you prevent …


Detectability Of Circulating Micrornas In Microrna Extracts With Low Purity And Yield Using Quantitative Real-Time Polymerase Chain Reaction: Supporting Evidence, Azmir Ahmad, Mohd. Arifin Kaderi, Afidalina Tumian, Vijaya Mohan Sivanesan, Kahairi Abdullah, Wan Ishlah Leman, Irfan Mohamad, Wan Mohd. Nazri Wan Zainon, Muhammad Izani Mohd. Shiyuti, Kamariah Mohamed Awang, Luqman Rosla, Mark Paul, Sharifah Nor Ezura Syed Yussof, Rosdi Ramli Dec 2020

Detectability Of Circulating Micrornas In Microrna Extracts With Low Purity And Yield Using Quantitative Real-Time Polymerase Chain Reaction: Supporting Evidence, Azmir Ahmad, Mohd. Arifin Kaderi, Afidalina Tumian, Vijaya Mohan Sivanesan, Kahairi Abdullah, Wan Ishlah Leman, Irfan Mohamad, Wan Mohd. Nazri Wan Zainon, Muhammad Izani Mohd. Shiyuti, Kamariah Mohamed Awang, Luqman Rosla, Mark Paul, Sharifah Nor Ezura Syed Yussof, Rosdi Ramli

Makara Journal of Health Research

Background: Circulating microRNAs (miRNAs) are a group of noncoding RNAs with promising potential as minimal invasive biomarkers for noncommunicable diseases. However, challenges exist in the preparation of these miRNAs from peripheral blood samples for quantification purposes. The low quality of miRNA extracts presents an obstacle. Acknowledging the superior performance of quantitative real-time polymerase chain reaction (qPCR) as gold standard for gene expression analysis, we conducted this study to observe the capabilities of qPCR using the Taqman® protocol in amplifying circulating miRNAs from miRNA extracts with low purity and yield.

Methods: miRNAs were extracted from thirty-six plasma samples that …


Sports Under Quarantine: A Case Study Of Major League Baseball In 2020, Kari L.J. Goold, Reynafe N. Aniga, Peter B. Gray Dec 2020

Sports Under Quarantine: A Case Study Of Major League Baseball In 2020, Kari L.J. Goold, Reynafe N. Aniga, Peter B. Gray

Anthropology Faculty Research

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This case study entailed a Twitter content analysis to address the pandemic-delayed start to Major League Baseball (MLB) in the shortened 2020 season. This case study helps address the overarching objective to investigate how the sports world, especially fans, responded to MLB played during the 2020 COVID-19 pandemic. The methods investigated the common themes and determined who used predetermined Twitter hashtags. We recorded how many times external links, photos, emojis, and the 30 MLB teams were mentioned in the 779 tweets obtained during 39 days of data retrieval. Results showed that …


Recovery Of Hippocampal-Dependent Learning Despite Blunting Reactive Adult Neurogenesis After Alcohol Dependence, Chelsea G. Nickell, K. Ryan Thompson, James R. Pauly, Kimberly Nixon Dec 2020

Recovery Of Hippocampal-Dependent Learning Despite Blunting Reactive Adult Neurogenesis After Alcohol Dependence, Chelsea G. Nickell, K. Ryan Thompson, James R. Pauly, Kimberly Nixon

Pharmaceutical Sciences Faculty Publications

Background:

The excessive alcohol drinking that occurs in alcohol use disorder (AUD) causes neurodegeneration in regions such as the hippocampus, though recovery may occur after a period of abstinence. Mechanisms of recovery are not clear, though reactive neurogenesis has been observed in the hippocampal dentate gyrus following alcohol dependence and correlates to recovery of granule cell number.

Objective:

We investigated the role of neurons born during reactive neurogenesis in the recovery of hippocampal learning behavior after 4-day binge alcohol exposure, a model of an AUD. We hypothesized that reducing reactive neurogenesis would impair functional recovery.

Methods:

Adult male rats were …


Medical Marijuana And Opioids (Memo) Study: Protocol Of A Longitudinal Cohort Study To Examine If Medical Cannabis Reduces Opioid Use Among Adults With Chronic Pain, Chinazo O. Cunningham, Joanna L. Starrels, Chenshu Zhang, Marcus A. Bachhuber, Nancy L. Sohler, Frances R. Levin, Haruka Minami, Deepika E. Slawek, Julia H. Arnsten Dec 2020

Medical Marijuana And Opioids (Memo) Study: Protocol Of A Longitudinal Cohort Study To Examine If Medical Cannabis Reduces Opioid Use Among Adults With Chronic Pain, Chinazo O. Cunningham, Joanna L. Starrels, Chenshu Zhang, Marcus A. Bachhuber, Nancy L. Sohler, Frances R. Levin, Haruka Minami, Deepika E. Slawek, Julia H. Arnsten

School of Medicine Faculty Publications

Introduction In the USA, opioid analgesic use and overdoses have increased dramatically. One rapidly expanding strategy to manage chronic pain in the context of this epidemic is medical cannabis. Cannabis has analgesic effects, but it also has potential adverse effects. Further, its impact on opioid analgesic use is not well studied. Managing pain in people living with HIV is particularly challenging, given the high prevalence of opioid analgesic and cannabis use. This study's overarching goal is to understand how medical cannabis use affects opioid analgesic use, with attention to Δ9-tetrahydrocannabinol and cannabidiol content, HIV outcomes and adverse events. Methods and …


Modulation Of Aub-Tdrd Interactions Elucidates Pirna Amplification And Germplasm Formation., Nicholas Vrettos, Manolis Maragkakis, Panagiotis Alexiou, Paraskevi Sgourdou, Fadia Ibrahim, Daniel Palmieri, Yohei Kirino, Phd, Zissimos Mourelatos Dec 2020

Modulation Of Aub-Tdrd Interactions Elucidates Pirna Amplification And Germplasm Formation., Nicholas Vrettos, Manolis Maragkakis, Panagiotis Alexiou, Paraskevi Sgourdou, Fadia Ibrahim, Daniel Palmieri, Yohei Kirino, Phd, Zissimos Mourelatos

Computational Medicine Center Faculty Papers

Aub guided by piRNAs ensures genome integrity by cleaving retrotransposons, and genome propagation by trapping mRNAs to form the germplasm that instructs germ cell formation. Arginines at the N-terminus of Aub (Aub-NTRs) interact with Tudor and other Tudor domain-containing proteins (TDRDs). Aub-TDRD interactions suppress active retrotransposons via piRNA amplification and form germplasm via generation of Aub-Tudor ribonucleoproteins. Here, we show that Aub-NTRs are dispensable for primary piRNA biogenesis but essential for piRNA amplification and that their symmetric dimethylation is required for germplasm formation and germ cell specification but largely redundant for piRNA amplification.


Entrapment Of A Partially Degloved Stent In The Radial Artery: Is There Any Way Out?, Nooraldaem Yousif, Husam A. Noor Dec 2020

Entrapment Of A Partially Degloved Stent In The Radial Artery: Is There Any Way Out?, Nooraldaem Yousif, Husam A. Noor

Journal of the Saudi Heart Association

Stent loss during percutaneous coronary intervention (PCI) is uncommon but may lead to serious adverse events. Here we describe a challenging case of stent loss in the radial artery during primary PCI. There, a long stent failed to cross the culprit lesion, and an attempt to pull back the undeployed stent into the guiding catheter resulted in eversion of the stent, partially stripping it off the stent balloon and rendering the stent irretrievable. Retrieval of the stent at all costs might have led to major complications; hence stent deployment in the radial artery bailed us out of this precarious situation.


Differential Effects Of Rasa3 Mutations On Hematopoiesis Are Profoundly Influenced By Genetic Background And Molecular Variant., Ray F. Robledo, Steven L. Ciciotte, Joel H Graber, Yue Zhao, Amy J Lambert, Babette Gwynn, Nathaniel J Maki, Elena C Brindley, Emily Hartman, Lionel Blanc, Luanne L. Peters Dec 2020

Differential Effects Of Rasa3 Mutations On Hematopoiesis Are Profoundly Influenced By Genetic Background And Molecular Variant., Ray F. Robledo, Steven L. Ciciotte, Joel H Graber, Yue Zhao, Amy J Lambert, Babette Gwynn, Nathaniel J Maki, Elena C Brindley, Emily Hartman, Lionel Blanc, Luanne L. Peters

Faculty Research 2020

Studies of the severely pancytopenic scat mouse model first demonstrated the crucial role of RASA3, a dual RAS and RAP GTPase activating protein (GAP), in hematopoiesis. RASA3 is required for survival in utero; germline deletion is lethal at E12.5-13.5 due to severe hemorrhage. Here, conditional deletion in hematopoietic stem and progenitor cells (HSPCs) using Vav-iCre recapitulates the null phenotype demonstrating that RASA3 is required at the stem and progenitor level to maintain blood vessel development and integrity and effective blood production. In adults, bone marrow blood cell production and spleen stress erythropoiesis are suppressed significantly upon induction of RASA3 deficiency, …


2020-12-28_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services Dec 2020

2020-12-28_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Hospitals. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.