Medicine and Health Sciences Commons^™

Grk6 Regulates The Hemostatic Response To Injury Through Its Rate-Limiting Effects On Gpcr Signaling In Platelets., Xi Chen, Shuchi Gupta, Matthew Cooper, Daniel Dehelian, Xuefei Zhao, Meghna U. Naik, Jeremy G.T. Wurtzel, Timothy J. Stalker, Lawrence E. Goldfinger, Jeffrey Benovic, Lawrence F. Brass, Steven E. Mckenzie, Ulhas P. Naik, Peisong Ma

Cardeza Foundation for Hematologic Research

G protein-coupled receptors (GPCRs) mediate the majority of platelet activation in response to agonists. However, questions remain regarding the mechanisms that provide negative feedback toward activated GPCRs to limit platelet activation and thrombus formation. Here we provide the first evidence that GPCR kinase 6 (GRK6) serves this role in platelets, using GRK6-/- mice generated by CRISPR-Cas9 genome editing to examine the consequences of GRK6 knockout on GPCR-dependent signaling. Hemostatic thrombi formed in GRK6-/- mice are larger than in wild-type (WT) controls during the early stages of thrombus formation, with a rapid increase in platelet accumulation at the site of injury. …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Reports on Mixture Ranked Set Sampling for Estimation of Population Mean and Median

Biophysical Changes Caused By Altered Muc13 Expression In Pancreatic Cancer Cells, Andrew E. Massey, Kyle Doxtater, Murali M. Yallapu, Subhash C. Chauhan

School of Medicine Publications

Background

Pancreatic cancer is one of the most lethal cancers in the United States. This is partly due to the difficulty in early detection of this disease as well as poor therapeutic responses to currently available regimens. Our previous reports suggest that mucin 13 (MUC13, a transmembrane mucin common to gastrointestinal cells) is aberrantly expressed in this disease state, and has been implicated with a worsened prognosis and an enhanced metastatic potential in PanCa. However, there is virtually no information currently to describe the biophysical ramifications of this protein.

Methods

To demonstrate the biophysical effect of MUC13 in PanCa, we …

A&P Workshop Summary—Uniting Anatomy And Physiology Through Case Studies, Angela Horner, Stuart Sumida, Tomasz Owercowicz

Q2S Enhancing Pedagogy

Introducing problem-solving based methods of pedagogy is one approach to engage students early in their careers with developing analytic and diagnostic skills. PBL approaches in anatomy and medical teaching are a logical extension of clinical case studies, wherein an example of a pathology or clinical procedure is provided, and students must ascertain the anatomical and/or physiological basis for it. Students report a deeper understanding of material presented in clinical case studies, as the ‘real world’ relevance and importance is immediately clear (Cliff and Wright, 1996).

Sex Differences In The Effects Of Exercise On Cognition Post-Stroke: Secondary Analysis Of A Randomized Controlled Trial, Shereen Khattab, Janice J. Eng, Teresa Liu-Ambrose, Julie Richardson, Joy Macdermid, Ada Tang

Bone and Joint Institute

OBJECTIVE: To determine whether there are differences in exercise-associated changes in cognitive func-tion between males and females living with stroke. DESIGN: Secondary analysis of data from a prospective assessor-blinded randomized controlled trial. PARTICIPANTS: Fifty participants (50-80 years, > 1 year post-stroke, able to walk ≥ 5 m). METHODS: Participants were allocated into a 6-month aerobic exercise programme (14 males, 11 females) or balance and flexibility programme (15 males, 10 females). Working memory (Verbal Digit Span Backwards Test), selective attention and conflict resolution (Stroop Colour-Word Test), and set shifting/cognitive flexibility (Trail-Making Test B) were assessed before and after the programmes. RESULTS: There …

Effects Of The Affordable Care Act On The Receipt Of Colonoscopies Among The Insured Elderly, Minjee Lee, M Mahmud Khan, Heather M. Brandt, Ramzi G. Salloum, Brian Chen

Faculty Publications

BACKGROUND: The Affordable Care Act (ACA) waived deductibles and eliminated coinsurance for colonoscopies for Medicare beneficiaries beginning in January 1, 2011. This study investigated the effect of the ACA's directive to remove the financial barriers on the receipt of colonoscopies among the elderly insured, who are predominantly covered by Medicare. METHODS: Data from the 2008-2016 Behavioral Risk Factor Surveillance System (BRFSS) were used to examine the receipt of colonoscopies in two years prior to the implementation of the ACA (2008 and 2010) and three years after the change (2012, 2014, and 2016). Multivariate logistic regressions were estimated to examine the …

Causes And Risk Factors Of Hospitalization Among Under-Five Children In Kassala, Eastern Sudan, Ahmed A. Hassan, Zainab Taha, Mohammed A. Abdulla, Abdelaziem A. Ali, Ishag Adam

All Works

© 2020 Ahmed A. Hassan, Zainab Taha, Mohammed A. Abdulla, AbdelAziem A. Ali, Ishag Adam. BACKGROUND: According to the World Health Organization estimation, African Region deaths of all under-five deaths in 2015 were over 5 times higher in comparison to the European Region. AIM: The study aimed to estimate the prevalence, investigate the possible causes and risk factors associated with under-five children’s hospitalization in Kassala, Eastern Sudan. METHODS: A community-based cross-sectional study was conducted from December 2015 to March 2016. The data were collected by interviewing mothers. RESULTS: A total of 297 mother-child pairs participated in the study. The mean …

Local Adaptation Constrains Drought Tolerance In A Tropical Foundation Tree, Kasey E. Barton, Casey Jones, Kyle F. Edwards, Aaron B. Shiels, Tiffany Knight

United States Department of Agriculture Wildlife Services: Staff Publications

1. Plant species with broad climatic ranges might be more vulnerable to climate change than previously appreciated due to intraspecific variation in climatic stress tolerance. In tropical forests, drought is increasingly frequent and severe, causing widespread declines and altering community dynamics. Yet, little is known about whether foundation tropical trees vary in drought tolerance throughout their distributions, and how intraspecific variation in drought tolerance might contribute to their vulnerability to climate changE.
2. We tested for local adaptation in seedling emergence and establishment with a full-factorial reciprocal transplant experiment including 27 populations and 109,350 seeds along a 3,500 mm precipitation gradient for …

Efficacy Of Osteoporosis Prevention Smartphone App, Polly Ryan, Roger L. Brown, Mary Ellen Csuka, Paula E. Papanek

Exercise Science Faculty Research and Publications

Background

The Striving to be Strong study tested the efficacy of a multifaceted, theory-based, complex osteoporosis prevention smartphone application (app). We hypothesized use of the app would improve bone mineral density and trabecular bone scores.

Methods

The study was a three-group, prospective, repeated-measure, longitudinal randomized trial. Baseline sample consisted of 290 healthy women between 40 and 60 years of age. Participants were randomly assigned to one of three groups: “Striving,” a dynamically tailored, person-centered app; “Boning Up,” a standardized osteoporosis-education e-book; and “Wait List,” a participant’s choice of intervention in the final 3 months of the 12-month study. Participants had …

Toward Improving Practices For Submission Of Diagnostic Tissue Blocks For National Cancer Institute Clinical Trials, Hala Makhlouf, Mark A Watson, Heather A Lankes, Carol Weil, Maura Dickler, Michael Birrer, Christopher Moskaluk, Nilsa C Ramirez, Nader Okby, Edgar Alonsozana, Mark Barnes, Edward B Goldman, Rebecca Enos, Irina Lubensky

2020-Current year OA Pubs

OBJECTIVES: The National Cancer Institute (NCI) National Clinical Trials Network performs phase II and III clinical trials, which increasingly rely on the submission of diagnostic formalin-fixed, paraffin-embedded tissue blocks for biomarker assessment. Simultaneously, advances in precision oncology require that clinical centers maintain diagnostic specimens for ancillary, standard-of-care diagnostics. This has caused tissue blocks to become a limited resource for advancing the NCI clinical trial enterprise and the practice of modern molecular pathology.

METHODS: The NCI convened a 1-day workshop of multidisciplined experts to discuss barriers and strategic solutions to facilitate diagnostic block submission for clinical trial science, from the perspective …

Detecting Invasive Fungal Disease In Surgical Patients: Utility Of The (1 3)- B-D-Glucan Assay, Jeffrey Skubic, Sharven Taghavi, Manuel Castillo-Angeles, Ramsis Ramsis, Ali Salim, Reza Askari

School of Medicine Publications

Background: The specificity and sensitivity of the (1 3)-b-d-glucan (BDG) assay in surgical patients needs further investigation. We hypothesized that the BDG assay would have lower sensitivity/specificity compared with that of medical patients.

Methods: We reviewed patients who had undergone laparotomy, gastrectomy, hepatectomy, or colectomy and had a BDG assay post-operatively.

Results: A total of 71 patients met study criteria. There were 29 (40.8%) who had proven/probable invasive fungal infection. Sensitivity for BDG level ‡80 diagnosed within one week of the assay draw was 77.3% (95% confidence interval [CI], 54.6–92.2%), and specificity was 44.9% (95% CI, 30.7–59.8). The positive predictive …

Evaluating The Effectiveness Of Online Educational Modules And Interactive Workshops In Alleviating Symptoms Of Mild To Moderate Depression: A Pilot Trial, Luis A. Murillo, Emily Follo, Julienne Balestrier, April Smith, Deborah L. Bevvino

Reading Hospital Family Medicine Residency

Introduction: Depression is a common health concern in primary care with barriers to treatment well documented in the literature. Innovative online psychoeducational approaches to address barriers to care have been well received and can be cost effective. This pilot trial evaluated the effectiveness of an online psychoeducation curriculum intended to alleviate symptoms of depression while utilizing minimal staff resources. Methods: A small (n=29) randomized control pilot study was conducted. Online psychoeducational content was delivered in 5 to 10-minute videos over 8weeks. Participants engaged in moderated discussions on workshop topics. The Patient Health Care Questionnaire (PHQ-9) was used to measure pre/ …

Nursing Annual Report 2019, Children's Mercy Hospital

Nursing Annual Reports

Annual report for nursing services at Children's Mercy Kansas City.

Hearing And Cognitive Impairments Increase The Risk Of Long-Term Care Admissions, Nicole Williams, Natalie Phillips, Walter Wittich, Jennifer C. Campos, Paul Mick, Joseph B. Orange, M Kathleen Pichora-Fuller, Marie Savundranayagam, Dawn M. Guthrie

Kinesiology and Physical Education Faculty Publications

Background and Objectives: The objective of the study was to understand how sensory impairments, alone or in combination with cognitive impairment (CI), relate to long-term care (LTC) admissions. Research Design and Methods: This retrospective cohort study used existing information from two interRAI assessments; the Resident Assessment Instrument for Home Care (RAI-HC) and the Minimum Data Set 2.0 (MDS 2.0), which were linked at the individual level for 371,696 unique individuals aged 65+ years. The exposure variables of interest included hearing impairment (HI), vision impairment (VI) and dual sensory impairment (DSI) ascertained at participants’ most recent RAI-HC assessment. The main outcome …

Development And Validation Of A Prognostic Survival Model For Cancer Patients That Includes Patient Reported Outcomes., Hsien Seow, Peter Tanuseputro, Lisa Barbera, Craig Earle, Dawn M. Guthrie, Sarina Isenberg, Rosalyn Juergens, Melissa Brouwers, Jeff Myers, Rinku Sutradhar

Kinesiology and Physical Education Faculty Publications

Importance Existing prognostic cancer tools include biological and laboratory variables. However, patients often do not know this information, preventing them from using the tools and understanding their prognosis.

Objective To develop and validate a prognostic survival model for all cancer types that incorporates information on symptoms and performance status over time.

Design, Setting, and Participants This is a retrospective, population-based, prognostic study of data from patients diagnosed with cancer from January 1, 2008, to December 31, 2015, in Ontario, Canada. Patients were randomly selected for model derivation (60%) and validation (40%). The derivation cohort was used to develop a multivariable …

Community Outreach And Education Project: Hepatitis A And B Vaccines In High Risk Populations, Ellen Wright

Master of Science in Nursing Theses and Projects

The Community Outreach and Education Project targets high risk groups within Gaston County to increase education and vaccination against Hepatitis to, in turn, lower countywide Hepatitis rates. Through implementation of the project, Gaston County Department of Health and Human Services-Public Health (GCDHHS-PH) will partner with Community sponsors to gain access to their high-risk clients. Sponsors will be educated on the impact of prompt intervention in slowing the spread of hepatitis throughout high risk groups. Once an agreement is made between GCDHHS-PH and Community sponsors, GCDHHS-PH will present to participating facilities and begin screening, educating, and vaccinating high-risk individuals.

Single- And Dual-Energy Ct: A Comparison, Emilee Bixler

Student Research Poster Presentations 2020

This research offers a comparison of two types of computed tomography (CT) configurations by exploring each scanner type and the accompanying image specifications, protocols, radiation doses, geometric aspects, and photographic aspects of the resulting images. The comparison aimed to determine if single-energy CT (SECT) or dual-energy CT (DECT) had any clear advantages over the other scanner type. Several studies in the research resulted in DECT displaying a decrease in dose without compromising contrast-to-noise ratio (CNR). The studies in this research also showed DECT had a superior ability of decreasing iodine by 70% concentration dose while obtaining the same image quality …

Evidence Based Practice Positively Affects The Delivery Of Nursing Care, Miranda Lee

Student Research Poster Presentations 2020

No abstract provided.

Breast Density Awareness, Alyssa Acker

Student Research Poster Presentations 2020

Breast density refers to the amount of fibrous and glandular tissue in comparison to fatty tissue demonstrated on a mammogram. A woman’s breast density is significant because as the density of the tissue increases, the woman’s risk for developing breast cancer increases and the more challenging for microcalcifications or lesions to be seen on mammography images. The Mammography Quality Standards Act, requires radiologists or imaging facilities to send each patient a written summary of their mammogram report and communicate to the patient if their results suggest further imaging. In addition to this requirement, 38 states that have passed a Breast …

The Use Of Cyberknife Stereotactic Body Radiation Therapy In Treating Hepatocellular Carcinoma, Alexis Baddick

Student Research Poster Presentations 2020

Radiation therapy is an ever-changing field, making it easier and safer to treat a broader range of cancers. With the advancement of the CyberKnife System, we can now investigate how effective stereotactic body radiation therapy (SBRT) treatments are in terms of treating hepatocellular carcinoma (HCC) patients. HCC is the most common liver cancer as well as one of the most prominent cancer-related deaths in the world. Several studies indicated that, previously, treating HCC with ionizing radiation was not an effective option due to the liver’s sensitivity to radiation, among other factors. After conducting research and examining nine different sources, there …

The Sonographic Progression Of Non-Alcoholic Fatty Liver Disease Into Non-Alcoholic Cirrhosis Of The Liver, Giana Tondora

Student Research Poster Presentations 2020

Cirrhosis is quickly becoming a prevalent disease in the United States alone and affects 1 in every 400 Americans. Cirrhosis occurs when the liver's fibrous bands are no longer fibrous in response to the liver being scarred and no longer being able to filter toxins from the blood. Ultrasound is a key tool along with blood tests that allows cirrhosis to definitively be detected and diagnosed in patients. Cirrhosis can be either non-alcoholic or alcoholic depending on the patient’s history and there are distinct differences in appearance of the liver sonographically as well as symptoms and treatment of this disease …

The Managemed Screening As A Tool For Discharge Planning, Manpreet Nijjar

OT Student Capstones

The ManageMed Screen was used as a tool for discharge planning from a post-acute rehab setting to reduce readmission rates. The goal was to identify barriers to medication adherence. Medication adherence is best explained as the extent to which patients follow the given instructions for prescribed medication.

The Fostering Healthy Parents Program: A Specialized Program Developed For The Foster Care Community, Kelly Cregar

OT Student Capstones

Foster children and their caregivers are underrepresented and overlooked in many aspects of their care. Lack of resources and services leave them in the dark, both financially and medically, resulting in around a 50% guardian retention rate (National Council for Adoption, 2018). Constantly being uprooted and either placed in a new home or a group home, foster children rarely achieve a feeling of belonging, leading to a plethora of health problems (Fawley-King, Trask, Zhang, & Aarons, 2017). Occupational therapists have the potential to develop programs that encourage development and progression in this demographic, as well as programs that allow for …

The Perceived Benefits Of Counseling Provided To First Responders Through The Officer Craig Tiger Act, Matthew Wittwer

OT Student Capstones

Importance: Responding to traumatic incidents can cause negative effects on first responders mental and physical health. In 2018, Arizona passed the Officer Craig Tiger Act requiring state funded departments and agencies to provide sworn firefighters and police officers with 36 licensed counseling visits following a traumatic event. Objective: This cross-sectional study looks at the perceived benefits of the Act through the perspective of the first responders. Methods: A survey was completed by 65 first responders. The survey included the Quality of Life Scale (QOLS), the PTSD Checklist for DSM-5 (PCL-5), the Perceived Stress Scale (PSS), and a questioner to gather …

Neuropsychological Test Performance In Individuals With Persistent Post-Concussion Symptoms: A Data-Driven Method To Conceptualize Ot Cognitive Rehabilitation Toward Return-To-Work, Naomi Melendez

OT Student Capstones

Cognitive deficits, secondary to concussion, can impact return to work; people may be held from work due to symptoms. Common difficulties include trouble learning new tasks, or needing more time to perform job tasks. In 10-20% of cases, symptoms can persist for months, and are more likely to persist one year post-injury. Studies have examined cognitive performance after concussion with mixed results, warranting further research in cognitive deficits and cognitive rehabilitation. The OT scope of practice is inclusive of rehabilitation at the physical, cognitive, and affective domains; however, concussion cognitive rehabilitation services are under-represented in literature.

The purpose of this …

Writing Intensive Project In The Dietetic Program, Dorothy Chen-Maynard

Q2S Enhancing Pedagogy

As a member of Faculty Learning Community Writing Intensive Project, we developed a project for the course that allow students to write where instructor provides a scaffolding process for students to write a review manuscript for a professional journal.

Registered Nurse Perception Of Physician Assistants, Erin Renee Alpers, Linda Charles, Kaitlyn Mellesmoen

All Electronic Theses and Dissertations

The physician assistant (PA) profession is a relatively new and ever-growing field within healthcare. PAs serve patients in many different specialties alongside a wide variety of other members of healthcare teams. With the exponential growth of the PA profession the understanding of the role they provide is essential to other healthcare workers. Since the emergence of the PA there has been one study on the relationship between Registered Nurses (RNs) and PAs, and this occurred over thirty years ago. An understanding between team members continues to be key to promoting effective care of patients in healthcare teams. Therefore, the study …

Adolescents & Long Acting Reversible Contraception, Nicole Elizabeth Amstutz, Jessica Kesterson

All Electronic Theses and Dissertations

Background/Purpose: The purpose of this literature appraisal is to assess adolescent access to long-acting reversible contraception (LARCs). Theoretical Framework: The Health Belief Model (HBM) helps describe the psychological and behavioral underpinnings of how one cares for one’s health. The HBM can be applied to how adolescents perceive the risks associated with unprotected intercourse compared to the perceived benefits of LARC usage. The HBM considers the benefits, barriers, risk of susceptibility, risk severity, self-efficacy, and cues to the action of adopting positive health interventions in one’s life (Jones et al., 2016). Methods: Twenty-four relevant articles from the literature were appraised. Results/Findings: …

A Community Service Project: Creating Awareness Of Chronic Malnutrition In Guatemalan Children, Mallory A. Beswick, Bree A. Blanchette, Brooke L. Elvehjem

All Electronic Theses and Dissertations

Guatemala City is home to one of Central America’s largest garbage dumps. Many individuals living in Guatemala City scavenge the dump for recyclables and other goods, that they can then sell for income. Family earnings vary greatly on a daily basis and can range anywhere from approximately $2.00 to $6.00. Since family income is very low and often unpredictable, many families living in the area struggle to supply not only a sufficient amount of food for their children, but also nutritious food needed for proper growth and development. As a result, many children in Guatemala face chronic malnutrition. Transforming Futures, …

Addictions Following Bariatric Surgery: A Critial Review Of The Literature, Anna Hansene Bjork

All Electronic Theses and Dissertations

Background: Bariatric surgery has become increasingly common for the treatment of obesity. Research and education are needed to identify and study potential post-surgical risks including alcohol use disorders and other physiological and psychological comorbidities. Purpose: The purpose of this critical review of the literature was to study and identify addiction after bariatric surgery, specifically alcohol use disorder. Theoretical/Conceptual Framework: Rosenstock’s Health Belief Model (1988) was used to correlate theory and addiction. In particular, how health beliefs differ between patients, and their perception of addiction. This allows nurses to apply strategies that influence or educate patients on making healthy lifestyle changes. …