Medicine and Health Sciences Commons^™

Metabolic Dysregulation In The Atp7b-/- Wilson's Disease Mouse Model, Clavia Ruth Wooton-Kee, Matthew Robertson, Ying Zhou, Bingning Dong, Zhen Sun, Kang Ho Kim, Hailan Liu, Yong Xu, Nagireddy Putluri, Pradip Saha, Cristian Coarfa, David D Moore, Alli M Nuotio-Antar

Faculty, Staff and Students Publications

Inactivating mutations in the copper transporter Atp7b result in Wilson’s disease. The Atp7b−/− mouse develops hallmarks of Wilson’s disease. The activity of several nuclear receptors decreased in Atp7b−/− mice, and nuclear receptors are critical for maintaining metabolic homeostasis. Therefore, we anticipated that Atp7b−/− mice would exhibit altered progression of diet-induced obesity, fatty liver, and insulin resistance. Following 10 wk on a chow or Western-type diet (40% kcal fat), parameters of glucose and lipid homeostasis were measured. Hepatic metabolites were measured by liquid chromatography–mass spectrometry and correlated with transcriptomic data. Atp7b−/− mice fed a chow diet presented …

Improving Environmental Capacities For Health Promotion In Support Settings For People With Intellectual Disabilities: Inclusive Design Of The Dihasid Tool, Kristel Vlot-Van Anrooij, Thessa I. M. Hilgenkamp, Geraline L. Leusink, Anneke Van Der Cruijsen, Henk Jansen, Jenneken Naaldenberg, Koos Van Der Velden

Physical Therapy Faculty Research

People with intellectual disabilities (ID) have unhealthier lifestyles than the general population. To sustainably improve their lifestyle and health status, a whole-system approach to creating healthy environments is crucial. To gain insight into how support for physical activity and healthy nutrition can be embedded in a setting, asset mapping can be helpful. Asset mapping involves creating a bottom–up overview of promoting and protective factors for health. However, there is no asset mapping tool available for ID support settings. This study aims to develop an asset mapping tool in collaboration with people with ID to gain insight into assets for healthy …

Web-Based Graphic Representation Of The Life Course Of Mental Health: Cross-Sectional Study Across The Spectrum Of Mood, Anxiety, Eating, And Substance Use Disorders., Robin Leora Aupperle, Martin P. Paulus, Rayus Kuplicki, James Touthang, Teresa Victor, Hung-Wen Yeh, Tulsa 1000 Investigators, Sahib S. Khalsa

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Although patient history is essential for informing mental health assessment, diagnosis, and prognosis, there is a dearth of standardized instruments measuring time-dependent factors relevant to psychiatric disorders. Previous research has demonstrated the potential utility of graphical representations, termed life charts, for depicting the complexity of the course of mental illness. However, the implementation of these assessments is limited by the exclusive focus on specific mental illnesses (ie, bipolar disorder) and the lack of intuitive graphical interfaces for data collection and visualization.

OBJECTIVE: This study aimed to develop and test the utility of the Tulsa Life Chart (TLC) as a …

A Brief Educational Intervention Enhances Basic Cancer Literacy Among Kentucky Middle And High School Students, Lauren Hudson, Kerrigan M. Samons, Haley E. Dicken, Chris Prichard, L. Todd Weiss, Jean Edward, Robin C. Vanderpool, Nathan L. Vanderford

Markey Cancer Center Faculty Publications

Kentucky experiences the highest overall cancer incidence and mortality rates in the USA with the greatest burden in the eastern, Appalachian region of the state. Cancer disparities in Kentucky are driven in part by poor health behaviors, poverty, lack of health care access, low education levels, and low health literacy. Individuals with inadequate health literacy are less likely to participate in preventive measures such as obtaining screenings and making healthy lifestyle choices, thus increasing their chances of developing and dying from cancer. By increasing cancer literacy among youth and adults, it may be possible to decrease cancer disparities across Kentucky. …

Effect Of 5-Minute Movies Shown Via A Mobile Phone App On Risk Factors And Mortality After Stroke In A Low- To Middle-Income Country: Randomized Controlled Trial For The Stroke Caregiver Dyad Education Intervention (Movies4stroke), Ayeesha Kamran Kamal, Adeel Khoja, Bushra Usmani, Shahvaiz Magsi, Aresha Malani, Zahra Peera, Saadia Sattar, Masood Ahmed Akram, Sumaira Shahnawaz, Maryam Zulfiqar, Abdul Muqeet, Fabiha Zaidi, Saleem Sayani, Azmina Artani, Syed Iqbal Azam, Sarah Saleem

Section of Neurology

Background: Pakistan is the sixth most populous nation in the world and has an estimated 4 million stroke survivors. Most survivors are taken care of by community-based caregivers, and there are no inpatient rehabilitation facilities.
Objective: The objective of this study was to evaluate the effectiveness and safety of locally designed 5-min movies rolled out in order of relevance that are thematically delivered in a 3-month program to deliver poststroke education to stroke survivor and caregiver dyads returning to the community.
Methods: This study was a randomized controlled, outcome assessor–blinded, parallel group, single-center superiority trial in which participants (stroke survivor-caregiver …

Proteome Alterations In Pancreatic Ductal Adenocarcinoma, Sheng Pan, Teresa A Brentnall, Ru Chen

Faculty, Staff and Students Publications

Proteins are the essential functional biomolecules profoundly implicated in all aspects of pancreatic tumorigenesis and its progression. While common genomic factors, such as KRAS, TP53, SMAD4, and CDKN2A have been well recognized in association of pancreatic ductal adenocarcinoma (PDAC), our understanding of functional changes at the proteome level merits further investigation. Malignance associated proteome alterations can be attributed to the convoluted outcomes from genetic, epigenetic and environmental factors in initiating and progressing PDAC, and may reflect on changes in protein expressional level, structure, localization, as well as post-translational modifications (PTMs) status. The study of localized or systemic proteome alterations in …

Enzymatically Modified Isoquercitrin Improves Endothelial Function In Volunteers At Risk Of Cardiovascular Disease, Nicola P. Bondonno, Catherine P. Bondonno, Natalie C. Ward, Richard J. Woodman, Jonathan M. Hodgson

Research outputs 2014 to 2021

A higher intake of food rich in flavonoids such as quercetin can reduce the risk of CVD. Enzymatically modified isoquercitrin (EMIQ®) has a bioavailability 17-fold higher than quercetin aglycone and has shown potential CVD moderating effects in animal studies. The present study aimed to determine whether acute ingestion of EMIQ® improves endothelial function, blood pressure (BP) and cognitive function in human volunteers at risk of CVD. Twenty-five participants (twelve males and thirteen females) with at least one CVD risk factor completed this randomised, controlled, crossover study. In a random order, participants were given EMIQ® (2 mg aglycone equivalent)/kg body weight …

Quality Of Life Between Working And Non-Workingpalestinian Women, Olfat Mahmoud

BAU Journal - Health and Wellbeing

This study tackles a number of variables that form the core of positive psychology: self-efficacy, optimism, the estimations of physical health, mental health, happiness and satisfaction, in addition to the variable of healthy behavior which is deemed a new-comer in Arab studies. The study, thus, seeks to determine the differences between these variable in the light of sex, as well as the relation between healthy behavior and the variables of the study. It also seeks to identify the factors that can be extracted from the correlation coefficients among the scales used, and finally to identify the variables that may predict …

World View: Self Perceptionhow Do Traditional Healers See Themselves?A Comparative Study Between Two Tribes: The Kikuyu (Kenya) And El Gabaleya (Egypt), Iman El Bastawisi

BAU Journal - Health and Wellbeing

In terms of all the changing orientations and perspectives towards “Traditional Healing” as an activity and professional that might meet with the call of “back to nature”, the present research aims to shed light on the views and perceptions of the one who are truly and totally involved in this practition. By using the comparative method in presenting and analyzing two different cases : the case of a traditional healer from the Kikuyu tribe in Kenya and the case of a traditional healer from El Gabaleya tribe in Egypt. Field studies were carried out among both tribes and intensive in …

Development Of Hardiness Questionnaire A Psychometric Study On High School Students In Lebanon, Helga Alaeddine

BAU Journal - Health and Wellbeing

With the emergence of Positive Psychology in 1980, research moved from examining the effect of negative stressors to focusing on the exploration of positive variables that enhance an individual’s ability to face such stressors without the negative impact on their physical and mental health. Further, recent research seeks to study the personality traits which can alleviate the adverse effects of stressful life events. Psychologists have observed that crises and stress often lead to more hardy individuals compared to those who have not been through similar experiences or faced similar stress. Psychological hardiness is, therefore, one of the most prominent variables …

Caregiver Burden, Coping Mechanisms And Catharsis: An Exploratory Study, Triveni Goswami Vernal

BAU Journal - Health and Wellbeing

Adopting a qualitative approach, with narrative analysis, an attempt will be made to understand the experience of ‘Caregiver Burden’ amongst 5-7 primary caregivers of children with Autism, in India. An attempt will also be made to capture their coping mechanisms and cathartic behaviours, to reduce stress. To this end, a Caregiver Burden Inventory and an Open Ended questionnaire, touching upon the main issues, will be used. The study also aims to perceive how autonomy as a personality trait can play a significant role in empowering oneself as a caregiver and subsequently have noteworthy consequences on the coping mechanisms and cathartic …

Current Practices Of Community Pharmacists In Counseling Patients On Smoking Cessation In Beirut:A Questionnaire – Based Study, Mohamed Issa, Maya Elsolh, Lama Soubra

BAU Journal - Health and Wellbeing

Despite various strategies and efforts exerted in the form of awareness campaigns, health conferences, targeted advertisements and laws, the prevalence of smoking is alarmingly increasing for both genders in Lebanon. Because of the ease of accessibility, community pharmacists are ideally positioned to help their patients quit smoking. The current study aims to assess the Lebanese pharmacists’ practices in counseling their patients on smoking cessation. A cross-sectional study targeting community pharmacists in Beirut was conducted during June 2017 to September 2017. The adopted questionnaire was designed based on the WHO approved 5A’s toolkit program for delivering brief tobacco interventions in primary …

Does Durkheim's Theory Hold Any Truths For Modern Day Self-Immolation? A Review On The Literature, Mohsen Rezaeian

BAU Journal - Health and Wellbeing

Durkheim categorized suicide into four types as “egoistic”, “anomic”, “fatalistic”, and “altruistic”. He further hypothesized that the last two types i.e. “fatalistic” and “altruistic” are assigned to the then traditional society. However, in the present article and through literature review I will discuss that in modern society and especially within some low and middle income countries, self-immolation on its first and second most prevalent patterns i.e. to protest at micro and macro levels, respectively could be considered as a social self-sacrifice phenomenon. Therefore, it may well categorize as the altruistic type of suicide based on Durkheim’s theory.

Suicide And Culture, Mehmet Eskin

BAU Journal - Health and Wellbeing

The rates of suicidal ideation, attempts and mortality present a large intersocietal variation. This variation is usually attributed to the role of culture, but the issue is still poorly understood. How does culture contribute to the intersocietal or cross-cultural variation of suicidal behavior? How culture might be involved in the onset, maintenance and aggravation of suicidal tendencies? In this paper, I will be discussing possible mechanisms of culture for the onset, maintenance and aggravation of suicidal propensities. Specifically, I will be examining the role of religion, individualistic-collectivistic value orientations, self-construal and survival versus self-expression values for their relevance to suicidal …

Natural Narcotics: Phytochemical Content Analysis And Their Social Hazards, Kareem Raafat

BAU Journal - Health and Wellbeing

Narcotics can cause a wide range of adverse effects. The analysis of the narcotics phytochemical content utilizing rapid and efficient techniques have become of imminent need. The use of illegal drugs has been a long-standing problem in the world, a problem that has taken on a particular urgency in the last 30 years. The aim of the study is to develop comprehensive rapid technique in the field of phytochemical content analysis of narcotics, and to illustrate the role of the new narcotics on many psychological, physiological and social hazards, and giving recommendations on how to find solutions to these problems. …

Diabetes And Depression: Relation To Glycemic Control, Hala Ahmadieh

BAU Journal - Health and Wellbeing

Diabetes mellitus is a worldwide highly prevalent chronic metabolic disorder, characterized by hyperglycemia, and is associated with significant complications, including the microvascular complications such as neuropathy, retinopathy and nephropathy and the macrovascular complications such as cardiovascular, cerebrovascular disease and peripheral vascular disease, thus leading to significant morbidity and mortality. Patients with diabetes were found to be 1.4-3 times more likely to suffer from comorbid depression when compared to non-diabetics, and depression in diabetes is usually persistent and/or recurrent. Depression was found to be increased among patients with type I and type II diabetes mellitus, which have higher glycosylated hemoglobin. Association …

The Factor Structure Of Mental Health: Explanatory & Confirmatory Factor Structure Of Psychological Distress And Psychological Well-Being Measures, Badr El Ansari

BAU Journal - Health and Wellbeing

Psychological distress (PD) is usually based on the level of anxiety and depressive symptoms while psychological well-being (PW) is usually conceptualized as some combination of positive affective states such as happiness, optimism, satisfaction with life, and hope. This paper addresses the question of whether psychological distress and psychological well-being are the opposite poles of the same axis of mental health or independent constructs that should be measured on two independent axes. Methods: The sample consisted of (510) Kuwait University students, (240) males with a mean age of (24.08 ±5.10) and (270) females, with a mean age of (21.68 ±2.70), (f=46.77, …

Maternal Well-Being Therapy In Treating Depression In Johor City Of Malaysia, Akeel Khan, Deviga Marappan, Adibah Abdul Latif

BAU Journal - Health and Wellbeing

Maternal depression during pregnancy appears to be the most common and complicated psychological disorder in the world. Although maternal depression can be treated medically, consumption of antidepressant drugs could leave some kind of negative side effects on mother’s body and the baby in the womb. Therefore, the purpose of the current study is to determine the effectiveness of Maternal Well-being Therapy (MWT) in treating women with maternal depression. It is a qualitative study adapting case study research design. From the state of Johor city of Malaysia, four pregnant women who has scored 12 or more with suicidal thoughts symptoms on …

A Cuticular Romance, Anne F. Liu

Journal of Wellness

No abstract provided.

Books: The Original And Final Refuge For Mental Wellness, Kyle Christopher Miller

Journal of Wellness

An appreciation for literature and how reading fights to stay relevant in the fast moving era of technology.

What's Happening: January 27, 2020, Maine Medical Center

What's Happening

No abstract provided.

Optimal Bait Density For Delivery Of Acute Toxicants To Vertebrate Pests, Kim M. Pepin, Nathan P. Snow, Kurt C. Vercauteren

United States Department of Agriculture Wildlife Services: Staff Publications

Oral baiting is a fundamental method for delivering toxicants to pest species. Planning baiting strategies is challenging because bait-consumption rates depend on dynamic processes including space use and demographics of the target species. To determine cost-effective strategies for optimizing baiting, we developed a spatially explicit model of population dynamics using field-based measures of wild-pig (Sus scrofa) space use, bait consumption, and mortality probabilities. The most cost-effective baiting strategy depended strongly on the population reduction objective and initial density. A wide range of baiting strategies were cost-effective when the objective was 80% population reduction. In contrast, only a narrow range of …

Synthesis And Preliminary Ex Vivo Testing Of Sirna Targeting Tcrb: A Proposed Therapy For The Treatment Of Autoimmunity, Nicholas J. Magazine

LSU Doctoral Dissertations

Abstract

Background:

As of 2018, the United States National Institutes of Health estimate that over half a billion people worldwide are affected by autoimmune disorders. Though these conditions are prevalent, treatment options remain relatively poor, relying primarily on various forms of immunosuppression which carry potentially severe side effects and often lose effectiveness overtime. Given this, new forms of therapy are needed. We propose small-interfering RNA (siRNA) for hypervariable regions of the T-cell receptor β-chain gene (TCRb) as a highly targeted, novel means of therapy for the treatment of autoimmune disorders.

Objectives:

To develop methods to produce siRNA targeting …

A Feasibility Study Of Lavender Aromatherapy In An Awake Craniotomy Environment, Kailah Cathey, Nichole Gunyon, Nancy Chung, Nancy Conway, Diane Ames, Maharaj Singh, Amin B. Kassam, Richard A. Rovin

Journal of Patient-Centered Research and Reviews

Purpose: Integrative medicine interventions are needed for awake craniotomies, as many patients experience anxiety. Lavender aromatherapy significantly reduces anxiety or pain in a variety of surgical procedures. This feasibility study used lavender aromatherapy during awake craniotomies to determine the number of patients who would consent and complete the study, the technicality of lavender aromatherapy use, and acceptance by operating room (OR) staff.

Methods: We approached 40 consecutive patients (≥18 years old). Exclusion criteria were pulmonary issues or sensitivity to lavender. Outcome measures in consented patients were enrollment and completion rates, anxiety and pain as measured by the Visual Analog Scale …

Anxiety-Related Issues In Cancer Survivorship, Maresi A. Berry-Stoelzle, Anna C. Mark, Peter Kim, Jeanette M. Daly

Journal of Patient-Centered Research and Reviews

Purpose: The purpose of this qualitative study was to examine patient opinions about anxiety in cancer survivorship, particularly the role of the primary care provider in management of anxiety related to the trajectory of long-term cancer survivorship.

Methods: Respondents to a mass email (N = 22,000) were invited to participate in 1 of 3 institutional review board-approved focus group meetings. Inclusion criteria were being an adult patient older than 25 years of age, having any type of cancer diagnosis, and being at least 18 months from treatment. The following specific issues were discussed: role of the primary care provider …

Listening To The Patient: A Typology Of Contextual Red Flags In Disease Management Encounters, Amy E. Binns-Calvey, Gunjan Sharma, Naomi Ashley, Brendan Kelly, Frances M. Weaver, Saul J. Weiner

Journal of Patient-Centered Research and Reviews

Purpose: Patients send clues, often unwittingly, when they are grappling with a life challenge that complicates their care. For instance, a patient may lose control of a previously well-managed chronic condition or start missing appointments. When explored, these clues help clinicians uncover the life circumstance impacting the individual’s ability to manage their health and health care. Such clues are termed “contextual red flags.” Effective care requires recognizing them, asking about them, and customizing the care plan where feasible. We sought to develop a typology of contextual red flags by analyzing audio recordings along with the medical records of encounters between …

In Gratitude Of 2019 Jpcrr Peer Reviewers

Journal of Patient-Centered Research and Reviews

Journal of Patient-Centered Research and Reviews gratefully acknowledges the contributions of its submission reviewers from the previous year. Peer review is an essential component to publishing high-quality scientific literature. The editors thank these individuals for their generous volunteerism.

Week Of January 27, 2020, New York Medical College

InTouch

• NYMC Days of Giving Set for March 24 and 25
• Center for Disaster Medicine Hosts Training for White Plains Hospital
• SHSP Dean's Distinguished Leaders Lecture Series Features Leading Health Education Specialist
• Middle States Self-Study is Underway

Fenugreek Counters The Effects Of High Fat Diet On Gut Microbiota In Mice: Links To Metabolic Benefit, Annadora J. Bruce-Keller, Allison J. Richard, Sun-Ok Fernandez-Kim, David M. Ribnicky, J Michael Salbaum, Susan Newman Phd, Rn, Crrn, Faan, Richard Carmouche, Jacqueline M. Stephens

Publications

Fenugreek (Trigonella foenum-graecum) is an annual herbaceous plant and a staple of traditional health remedies for metabolic conditions including high cholesterol and diabetes. While the mechanisms of the beneficial actions of fenugreek remain unknown, a role for intestinal microbiota in metabolic homeostasis is likely. To determine if fenugreek utilizes intestinal bacteria to offset the adverse effects of high fat diets, C57BL/6J mice were fed control/low fat (CD) or high fat (HFD) diets each supplemented with or without 2% (w/w) fenugreek for 16 weeks. The effects of fenugreek and HFD on gut microbiota were comprehensively mapped and then statistically assessed in …

Brodifacoum Residues In Fish Three Years After An Island-Wide Rat Eradication Attempt In The Tropical Pacific, Shane R. Siers, Aaron B. Shiels, Steven F. Volker, Kristen Rex, William C. Pitt

United States Department of Agriculture Wildlife Services: Staff Publications

Invasive rats are known to threaten natural resources and human health and safety. Island-wide rat eradication attempts have been increasing in number and scale during the past several decades, as has the frequency of eradication success. The most common method to remove all rats from an island is to broadcast anticoagulant rodenticide bait into every rat’s home range on the island. Broadcast of toxicants can put humans and other nontarget species in marine and terrestrial environments at risk of exposure. The persistence of anticoagulant residues is somewhat unknown, particularly in marine environments. Three years after ~ 18,000 kg of 25 …