Medicine and Health Sciences Commons^™

De Novo Frameshift Variants In The Neuronal Splicing Factor Nova2 Result In A Common C-Terminal Extension And Cause A Severe Form Of Neurodevelopmental Disorder, Francesca Mattioli, Gaelle Hayot, Nathalie Drouot, Bertrand Isidor, Jérémie Courraud, Maria-Victoria Hinckelmann, Frederic Tran Mau-Them, Chantal Sellier, Alica Goldman, Aida Telegrafi, Alicia Boughton, Candace Gamble, Sebastien Moutton, Angélique Quartier, Nolwenn Jean, Paul Van Ness, Sarah Grotto, Sophie Nambot, Ganka Douglas, Yue Cindy Si, Jamel Chelly, Zohra Shad, Elisabeth Kaplan, Richard Dineen, Christelle Golzio, Nicolas Charlet-Berguerand, Jean-Louis Mandel, Amélie Piton

Faculty, Staff and Students Publications

The neuro-oncological ventral antigen 2 (NOVA2) protein is a major factor regulating neuron-specific alternative splicing (AS), previously associated with an acquired neurologic condition, the paraneoplastic opsoclonus-myoclonus ataxia (POMA). We report here six individuals with de novo frameshift variants in NOVA2 affected with a severe neurodevelopmental disorder characterized by intellectual disability (ID), motor and speech delay, autistic features, hypotonia, feeding difficulties, spasticity or ataxic gait, and abnormal brain MRI. The six variants lead to the same reading frame, adding a common proline rich C-terminal part instead of the last KH RNA binding domain. We detected 41 genes differentially spliced after NOVA2 …

Phosphoinositides In Retinal Function And Disease, Theodore G Wensel

Faculty, Staff and Students Publications

Phosphatidylinositol and its phosphorylated derivatives, the phosphoinositides, play many important roles in all eukaryotic cells. These include modulation of physical properties of membranes, activation or inhibition of membrane-associated proteins, recruitment of peripheral membrane proteins that act as effectors, and control of membrane trafficking. They also serve as precursors for important second messengers, inositol (1,4,5) trisphosphate and diacylglycerol. Animal models and human diseases involving defects in phosphoinositide regulatory pathways have revealed their importance for function in the mammalian retina and retinal pigmented epithelium. New technologies for localizing, measuring and genetically manipulating them are revealing new information about their importance for the …

Accessibility Of Hiv Testing In Baton Rouge Metropolitan Statistical Area, Alina Prigozhina

LSU Master's Theses

This study examines HIV testing accessibility in the Baton Rouge Metropolitan Statistical Area (BR MSA) using the two-step floating catchment area (2SFCA) method to calculate accessibility scores for free, low-cost and all other HIV testing facilities. The two goals of this research are to apply accessibility estimation methods to HIV testing facilities, and to examine the accessibility of HIV testing facilities in the BR MSA. To achieve these goals, this study uses several research methods. The data about HIV testing providers and their locations were collected through Internet searches. By means of a fieldwork, the data were checked, revealing that …

Crisis Communications: Facing Covid-19 Together Could Lead To Positive Psychological Growth, Lowri Dowthwaite

Social Space

Although news reports of hoarding, and panic-buying might make it hard to believe, research shows that natural disasters, like the COVID-19 pandemic, can actually bring out the best in people. Although times of significant threat or crisis can cause post-traumatic stress, research shows that so-called “adversarial growth” is just as common as a response. This is our capacity to not only overcome a crisis, but to actually grow stronger, wiser and more resilient.

Holding My Hand, Marylou Habecker

Reflections, Poetry, Photos, and other Writings

This is a piece that I have written to try to give HOPE to others in the middle of this crisis. A story I witnessed taken from another part of the world during a horrendous time of war gave me HOPE. He is Holding My Hand.

Senior Year Cut Short, Caleb Amick

Reflections, Poetry, Photos, and other Writings

This is my story of what happened to me during the last week of school before we left campus.

Day 10, Elise Wixtrom

Reflections, Poetry, Photos, and other Writings

This is a poem I wrote after visiting the supermarket right after classes closed on Taylor's campus.

The Effect Of Continuous Glucose Monitoring On Glycemic Control, Carlynn Turney

Physician Assistant Capstones

Countless studies have focused on determining the best medication, exercise and diet regimen to control blood sugar; nevertheless, management starts one step before blood glucose control. Clinicians and patients must have accurate data about blood glucose levels in order to appropriately adjust treatment.

In Patients With End-Stage Ankle Arthritis, How Does Total Ankle Arthroplasty Compared To Arthrodesis Affect Ankle Pain And Function?, Zachary Whipple

Physician Assistant Capstones

End-stage ankle arthritis is a debilitating degenerative disease commonly located at the tibiotalar joint. The prevalence of symptomatic arthritis is about nine times lower than the rates associated with those of the knee or hip.1 Though less common than knee and hip arthritis, the US estimates greater than 50,000 new cases are reported each year.2 The most common etiology of ankle arthritis is post-traumatic pathology. Other etiologies related to ankle degeneration include primary degenerative disease, rheumatoid disease, osteonecrosis, neuropathologies, infection, and gout.3 Injury to the joint damages the intraarticular cartilage leading to changes in joint mechanics. These alterations cause the …

Fatigue In Primary Care: Doctor, Why Am I So Tired?, Nina Mingioni, Md

Clinical Education Teaching Tools

Learning Objectives:

1. Identify top causes of fatigue in women
2. Develop an evidence-based approach to assessing a patient with fatigue
3. Reflect on the evidence for available screening tools for fatigue

Athletic Training Student Patient Encounter Characteristics During Immersive And Non-Immersive Experiences: A Report From The Athletic Training Clinical Network, Bailey Jones, Julie M. Cavallario, Cailee-Welch Bacon, Stacey Walker, Bonnie Van Lunen

College of Health Sciences Posters

Context: Professional athletic training programs are now required to include at least one immersive clinical experience (ICE), which allow students to see more patient-care opportunities and job responsibilities that athletic trainers complete than those at a non-immersive clinical experience (N-ICE). Therefore, the purpose of this study was to compare the characteristics of patient encounters (PEs) that occurred at ICEs and N-ICEs.

Methods: This study used a multi-site panel design in which 336 athletic training students from 12 professional, CAATE-accredited programs (5 undergraduate, 7 graduate) logged PEs for one academic year (2018-2019). PEs were documented in E*Value (MedHub, Minneapolis, MN), and …

Do States’ Immigrant-Friendly Policies Improve The Health Of Children Of Immigrants? The Impact Of Driver’S License Policies For Undocumented Immigrants And “Sanctuary” Policies On Access And Use Of Health Care, Heather Koball, Seth Hartig

Graduate School of Education

If 10.5 million undocumented immigrants are unable or afraid to access health care, medical needs will go unmet and, in the face of COVID-19, lives may be lost. This report explores how immigrant-friendly policies increase the chances that children of immigrants receive preventative health care, thus reducing the likelihood of having unmet medical needs and potentially reducing the chances of disease outbreaks.

Implementation Of A Chemotherapy Guideline: A Quality Improvement Project To Standardize The Chemotherapy Delivery Process, Sara Maciej

Nursing Posters

Adjusting chemotherapy rates is one gap in chemotherapy practice that evokes inconsistency. The purpose of this project was to implement a standardized guideline for staff to utilize in adjusting rates of chemotherapy medications.

Coronavirus Disease 2019 (Covid-19), Matthew Dunbar

Pharmacy Student Scholarship

No abstract provided.

Guide Lines Vol. Ii, Issue 2 - April 2020, College Of Health And Human Services

GUIDE Lines

Periodic Newsletter of the Governors State University - University of Illinois, Chicago - Disparities Education Cancer research training and education project (The GUIDE Project).

Identification Of Factors Affecting Clinical Management And The Outcomes In Patients With Guillain Barre Syndrome, Vijaynarayana Kunhikatta Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Introduction: Guillain Barre syndrome (GBS) is a rare autoimmune neurological disorder in which the body’s immune system attacks part of its peripheral nervous system resulting in limb and cranial nerve weakness often with respiratory compromise and limitation on physical function. The worldwide incidence of GBS ranges from 0.81 to 1.89 cases per 100000 person-years. Various factors such as age, symptoms and disease form that influence the outcome of GBS have been previously studied. This study seeks the additional fundamental knowledge of the factors affecting clinical management and the outcome in patients with GBS. Objective: To identify factors affecting clinical management …

The Effectiveness Of Visual Activity Schedule Intervention On Reducing Problem Behaviours In Children With Attention Deficit Hyperactivity Disorder Between 5 And 12 Years Of Age: A Systematic Review, Naveena Thomas

Kasturba Medical College, Mangalore Theses and Dissertations

No abstract provided.

Neonatal Dysphagia: A Case-Based Survey Of Speech Language Pathologists Practice Pattern In India, Mary Jose

Kasturba Medical College, Mangalore Theses and Dissertations

No abstract provided.

Com Outlook_Spring_ 2020, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Humna Elahi's Portfolio, Humna Elahi

Honors College Portfolios

As a student in the four-year Registered Nurse-Bachelor of Science in Nursing (RN-BSN) program, you are immersed in an education beyond the vital scientific facts and nursing skills. Throughout the undergraduate studies, one is challenged to rise to the skills of thorough assessments, critical thinking, and evaluations. Not only are you prepared for the clinical setting, you are given the tools to go above and beyond with your career. Your time and efforts as a nursing student creates a pathway to success and leadership.

A major goal in nursing is to practice cultural competence and provide holistic care to those …

Medication Errors Within The Clinical Setting: A Quality Improvement Project, Gracie Smith, Mary Thornburg, Connor Noble, Breanna Markwell, Sarah Rigsby, Suzi White

2022 Celebration of Student Scholarship - Poster Presentations

During a clinical rotation at a large urban teaching hospital, the occurrence of medication errors noted resulted in negative impacts on patient wellness. Research studies indicate that the U.S. spends more than $40 billion each year as a result of medication errors. A large portion of these medication errors are preventable. A thorough literature review of 40 research studies was conducted to identify issues associated with medication errors. This quality improvement project aims to identify the prevalence of medication errors, their effect on patient wellness, its monetary effects in healthcare, and what preventative interventions can be implemented to prevent such …

Integrated Multimodal Genomic Analyses Reveal Novel Mechanisms Of Glucocorticoid Resistance In Acute Lymphoblastic Leukemia, Robert J. Autry

Theses and Dissertations (ETD)

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Much has been discovered in recent decades regarding ALL biology, and the outcome of patients with ALL has vastly improved, especially in pediatric ALL patients. Despite very promising overall cure rates, patients who relapse have a greatly decreased prognosis with survival rates ranging from 30-60%. These numbers stand to improve even further with new targeted therapies that seek to improve or maintain cure rates while reducing treatment related toxicities which affect patients both acutely and chronically. Glucocorticoids (GCs) are essential components of modern chemotherapeutic intervention for ALL. Resistance to glucocorticoids …

Healthcare Educational Practices On Stigmatism Of Chronic Illness: A Qualitative Narrative Study, Audrey C. Tolouian

Nursing Faculty Publications

The problem is the identified stigma related to certain diseases affecting the quality of care provided by healthcare workers. Somatic diseases or those with vague signs and symptoms are subject to various stigmas. Due to the lack of a known cause of fibromyalgia, the disease is subject to stigma. The purpose of this qualitative narrative study was to bring awareness to healthcare educators about the potential impact of stigma. Educators may transfer stigma to their students, which may affect the quality of care. The research question guiding this study was, “How might healthcare educators’ perceptions of chronic illness transfer to …

Home-Based Learning Of A Covid-19 Work-From-Home Parent, Singapore Management University

Perspectives@SMU

After three months of managing a seven-year-old’s home-based learning, one parent discovered the secret of making it work: Cut your kid some slack

Covid-19 And Its Lessons For Innovation, Patrick Tan

Perspectives@SMU

As COVID-19 forces organisations to adapt, it also presents opportunities to innovate.

Circuit Breaker: Working From Home, Singapore Management University

Perspectives@SMU

How one company's early efforts to accomodate employees' work-life needs primed it for COVID-19-triggered work from home requirements

Measuring The Chinese Economic Impact Of Covid-19, Singapore Management University

Perspectives@SMU

The COVID-19 outbreak currently sweeping around the globe with deadly results will create hardships for a good proportion of businesses in China while generating new opportunities for others, says Jing Wu, Assistant Professor at The Chinese University of Hong Kong’s Department of Decision Sciences and Managerial Economics.

Locked Up And Locked Out: True Stories Of Individuals Who Experienced The Intersection Between Homelessness And The Criminal Justice System, Jean Johnson

Senior Honors Projects

JEAN JOHNSON (Criminology & Criminal Justice)

Locked Up and Locked Out: True Stories of the Interlocking Cycle of

Homelessness and the Criminal Justice System

Sponsor: Jill Doerner (Criminology & Criminal Justice, Sociology & Anthropology), Heather Johnson (Writing & Rhetoric)

Key locks work when a key made with teeth is placed into a cylinder with a series of pins and tumblers. If you don’t insert the right key one or more of the pins will remain in the way, preventing the key from turning and the lock will remain closed. According to the United States Interagency Council on Homelessness, tens of …

Developing A Web-Based Learning Experience For Nutrition Among Future Health And Sports Science Professionals, Melissa K. Casimir, Sandra Sertile, Emily Breen

Kean Quest

Nutrition education theories support the use of videos to help individuals take steps towards changing their behavior. The purpose of NOURISH (Nutrition Outreach to Undergrads in Sports Science and Health Professions) is to develop a multimedia, theory-based nutrition website for students preparing for careers in medicine and sports science. Research has shown that nutrition knowledge and resources are often limited for students pursuing careers in sports medicine or medicine. NOURISH was a collaboration with Kean University’s graphic design team to develop interactive review questions and a brief video to help students learn about pre-exercise hydration guidelines using the multimedia learning …

Hpv Knowledge, Attitudes, And Vaccination Among Hispanic/Latino College Students In The Usa, Itzel Corral Gonzalez, Wei-Chen Tung, Ho-Jui Tung, Wing Lam Tock

Faculty Publications

This study evaluated Human Papillomavirus-related knowledge and attitudes, vaccination practices, and explored associated factors among Hispanic/Latino college students in the United States of America. Using a self-administered survey, a descriptive, cross-sectional quantitative study was conducted in 2018 at colleges and universities in the United States of America. Our results indicate that Hispanic/Latino college students had a low level of HPV-related knowledge, a moderately positive attitude, and a moderate rate of HPV vaccination. Students who were in a health-related major, married/divorced, and had health insurance had greater knowledge and more positive attitudes towards HPV and its vaccines. This study is important …