Medicine and Health Sciences Commons^™

Evidence-Based Genetics And Identification Of Key Human Alzheimer’S Disease Alleles With Co-Morbidities, Duc Le, Nicolas Crouch, Alyssa Villanueva, Phong Ta, Roman Dmitriyev, Matthew Tunzi, Shin Murakami

Faculty Publications & Research of the TUC College of Osteopathic Medicine

Advancements in biomedical research have contributed to increasing the life expectancy of humans, but we now observe an increase in age-related diseases such as Alzheimer’s disease. Genome-Wide Association Studies (GWAS) and linkage studies have identified human genes associated with Alzheimer’s disease (referred to as AD genes). A previous study by Vahdati in 2017 has revealed the human AD genes and counterparts in model species [1]. Thus, we further investigate the co-morbidity genes and alleles. Using ontology analysis combined with cluster analysis, the study identified functional pathways enriched among the human AD genes, including 179 genes out of 695 human AD …

Prevalence Of Clinically Actionable Disease Variants In Exceptionally Long-Lived Families, Paige Carlson, Mary K Wojczynski, Todd Druley, Joseph H Lee, Joseph M Zmuda, Bharat Thyagarajan

2020-Current year OA Pubs

BACKGROUND: Phenotypic expression of pathogenic variants in individuals with no family history of inherited disorders remains unclear.

METHODS: We evaluated the prevalence of pathogenic variants in 25 genes associated with Mendelian-inherited disorders in 3015 participants from 485 families in the Long Life Family Study (LLFS). Boot-strapping and Fisher's exact test were used to determine whether allele frequencies in LLFS were significantly different from the allele frequencies reported in publicly available genomic databases.

RESULTS: The proportions of pathogenic autosomal dominant mutation carriers in BRCA1 and SDHC in LLFS study participants were similar to those reported in publicly available genomic databases (0.03% …

Drug Induced Liver Injury Is Associated With High Mortality- A Study From A Tertiary Care Hospital In Pakistan, Adeel Abid, Faryal Subhani, Farhana Kayani, Safia Awan, Shahab Abid

Medical College Documents

Background and aim: In light of few established drug induced liver injury (DILI) registries, this study aims to evaluate the clinical spectrum and predictors of mortality and morbidity of hospitalized patients with suspected DILI.
Patients and methods: DILI cases were identified and categorized on basis of COIMS/RUCAM score and the exclusion of other liver diseases. Clinical and laboratory parameters were analyzed to identify the predictors of morbidity (prolonged hospital stay > 5 days) and mortality.
Results: Out of 462 patients, there were 264 (57.6%) males and the mean age of the cohort was 50.83 years (range: 20-94 years). DILI was classified …

A Letter To The Graduating Class Of 2020, Ryan Kristofek

Reflections, Poetry, Photos, and other Writings

As a hall director in Wolgemuth overseeing seniors, I wrote a letter to these seniors as they navigate finishing their Taylor experience remotely.

Impact Of Meteorological Factors On The Covid-19 Transmission: A Multicity Study In China, Jiangtao Liu, Ji Zhou, Jinxi Yao, Xiuxia Zhang, Lanyu Li, Xiaocheng Xu, Xiaotao He, Bo Wang, Shihua Fu, Tingting Niu, Jun Yan, Yanjun Shi, Xiaowei Ren, Jingping Niu, Weihao Zhu, Sheng Li, Bin Luo, Kai Zhang

Publications and Research

The purpose of the present study is to explore the associations between novel coronavirus disease 2019 (COVID- 19) case counts and meteorological factors in 30 provincial capital cities of China. We compiled a daily dataset including confirmed case counts, ambient temperature (AT), diurnal temperature range (DTR), absolute humidity (AH) and migration scale index (MSI) for each city during the period of January 20th to March 2nd, 2020. First, we explored the associations between COVID-19 confirmed case counts, meteorological factors, and MSI using non-linear regression. Then, we conducted a two-stage analysis for 17 cities with more than 50 confirmed cases. In …

2020-04-09_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was captured from the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_99207---,00.html.

The website contained the table Count of Confirmed COVID-19 Cases by Date of Onset , sorted by Michigan Preparedness Region. It also contained 18 charts, including the count of confirmed Covid-19 cases by date of onset in the state overall as well as in each preparedness region,and the normalized rate of Covid-19 cases per 1,000,000 residents in both the state and in each preparedness region.

2020-04-09_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Data About Places.
It contains aggregated data, self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

2020-04-09_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., with COVID-19 results included as of 10 a.m.

Note on cumulative counts: This report is provisional and subject to change. As public health investigations of individual cases continue, there will be corrections to the status and details of referred cases that result in changes to this report.
Note on the deaths: Deaths must be reported by health care providers, medical examiners/coroners, and recorded by local health departments …

Covid 19 What You Need To Know, Dawn P. Wooley, Giancarlo Mariani, Craig Woolley, Laura M. Luehrmann

Neuroscience, Cell Biology & Physiology Faculty Publications

This is the first presentation in the new Shelter-in-Place lecture series. This first lecture is two-fold. First, it covers the basics of the COVID-19 virus including: how it spreads, possible origin, and other pertinent information. This portion of the presentation was followed by an overview of the international recruitment efforts in response to the virus, including: student perspectives, recruitment methods, and other important information.

2020-04-09 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Samuel Anyona, Evans Raballah, Shawn Stoicu, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Hannah Groves, Danielle Rivera, Estefania Montanez, Rachel D. King, Andrew S. Rowland, Orrin Myers, Kristine Tollestrup, Tudor I. Oprea, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

Today we began curating the firehose of National Library of Medicine COVID-19 Literature released daily. NM Governor gave weekly update. School online instruction starts Monday. Tribal communities in crisis. COVID-19 scams. NY food banks overwhelmed. Public sentiment survey. Arizona tracing outbreak with genomics. Abortion controversy continues. WHO Solidarity-II antibody study. South Korea epidemiology released. Preventing second COVID-19 wave. Institutional case reporting required. Gynecological procedure safety. Rationing ethics and advanced directives. CDC advice on exposed critical workers. Triaging urological procedures. Pathology safety and remote work. Healthcare workforce expansion. Involve and educate medical students. CDC no longer recommends hydroxychloroquine (HCQ). …

Shrines And Pilgrimages: Documenting Mary's Role In The Pandemic, Kayla Harris

Marian Library Faculty Presentations

A 1997 special report in Scientific American claimed that the average lifespan of a website was only 44 days. A study in 2001 put that at 75 days, while a 2003 article indicated 100 days. Everything on the Internet doesn’t last forever. The Marian Library has collected material related to the Blessed Virgin Mary since its founding in 1943. Increasingly, some of the material that would have once been printed, and possibly made their way to the Marian Library archives, is now being shared only electronically. Things like shrine Mass schedules, news articles, or blog posts are available on websites, …

How Do Counselors Support Clients During The Coronavirus Pandemic?, Yoon Suh Moh, Katharine Sperandio

Counseling and Behavioral Health Faculty Papers

It is impossible to deny the extraordinary societal impact of the outbreak of the novel coronavirus, severe acute respiratory syndrome 2 (SARS-Cov-2). All of us are bombarded daily with messages and information related to the pandemic. As this virus garners heightened attention from the media, individuals may have difficulty delineating between misinformation and accurate information about the illness.

We are not writing this article to perpetuate increased fear among the counseling community regarding the spread of the novel coronavirus, but rather to:

• Provide resources helpful for staying informed about the impact of COVID-19, which is a disease caused by SARS-Cov-2 …

Comparative Lipidomics Of 5-Fluorouracil-Sensitive And -Resistant Colorectal Cancer Cells Reveals Altered Sphingomyelin And Ceramide Controlled By Acid Sphingomyelinase (Smpd1)., Jae Hun Jung, Kohei Taniguchi, Hyeong Min Lee, Min Young Lee, Raju Bandu, Kazumasa Komura, Kil Yeon Lee, Yukihiro Akao, Kwang Pyo Kim

Articles, Abstracts, and Reports

5-Fluorouracil (5-FU) is a chemotherapeutic drug widely used to treat colorectal cancer. 5-FU is known to gradually lose its efficacy in treating colorectal cancer following the acquisition of resistance. We investigated the mechanism of 5-FU resistance using comprehensive lipidomic approaches. We performed lipidomic analysis on 5-FU-resistant (DLD-1/5-FU) and -sensitive (DLD-1) colorectal cancer cells using MALDI-MS and LC-MRM-MS. In particular, sphingomyelin (SM) species were significantly up-regulated in 5-FU-resistant cells in MALDI-TOF analysis. Further, we quantified sphingolipids including SM and Ceramide (Cer) using Multiple Reaction Monitoring (MRM), as they play a vital role in drug resistance. We found that 5-FU resistance in …

Biological Sex Influences Susceptibility To Acinetobacter Baumannii Pneumonia In Mice, Sílvia Pires, Adeline Peignier, Jeremy Seto, Davida S. Smyth, Dane Parker

Publications and Research

Acinetobacter baumannii (A. baumannii) is an extremely versatile multidrug-resistant pathogen with a very high mortality rate; therefore, it has become crucial to understand the host response during its infection. Given the importance of mice for modeling infection and their role in preclinical drug development, equal emphasis should be placed on the use of both sexes. Through our studies using a murine model of acute pneumonia with A. baumannii, we observed that female mice were more susceptible to infection. Likewise, treatment of male mice with estradiol increased their susceptibility to infection. Analysis of the airway compartment revealed enhanced inflammation and reduced …

Geographic Disparities In Covid-19 Testing: An Urgent Call To Action, Shannon M. Monnat, Kent Jason G. Cheng

Population Health Research Brief Series

This research brief shows that testing rates are lower in states with the unhealthiest populations and worst health care access. Disparities in testing rates are troubling because delays in testing increase the risk of a surge in silent spread and severe COVID-19 cases in these states.

A Crisis Is A Terrible Thing To Waste: Recovering A Sense Of Agency In Coronavirus Times, Steven F. Freeman

School of Continuing and Professional Studies Coronavirus Papers

No abstract provided.

2020-04-09 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

Arid1a Haploinsufficiency Initiates Neural Crest Transformation In A Mouse Model Of Mycn-Driven Neuroblastoma, Kirby A. Wallace

Theses and Dissertations (ETD)

Mouse models of cancer are critical for developing therapeutic treatments for pediatric patients. Recent sequencing studies of neuroblastoma (NBL) patient tumors have uncovered precise deletions in the chromatin remodeler and tumor suppressor gene (TSG) ARID1A. Additional causal studies supported ARID1A’s candidacy as a putative 1p36 TSG in MYCN-driven NBL. This study aimed to causally test Arid1a loss during Mycn-driven NBL initiation through the development of a mouse model of high risk NBL.In this study, we modified a Mycn-driven mouse model of NBL to incorporate Cre mediated deletion of floxed Arid1a. Briefly, in freshly isolated embryonic day 9.5 primary trunk neural …

Human Papillomavirus (Hpv) Vaccine Knowledge, Awareness And Acceptance Among Dental Students And Post-Graduate Dental Residents, Steve Kent Mann, Karl Kingsley

Dental Medicine Faculty Research

Introduction: The recent development of a vaccine that is highly effective against the human papillomavirus (HPV) has been met with widespread clinical and public health professional acceptance. However, social and societal barriers to vaccination may hamper public health efforts to prevent HPV-mediated diseases. Although a few studies have evaluated knowledge or awareness of HPV vaccination among dentists or dental educators, few studies have evaluated the acceptance, knowledge and awareness of HPV vaccination among dental students and post-graduate dental residents. The primary goal of this study is to evaluate survey responses regarding acceptance, knowledge and awareness of HPV vaccination among dental …

L’Utilizzo Del Tourniquet Nelle Emorragie Da Trauma In Ambito Civile: Una Revisione Narrativa Della Letteratura (Tourniquet In Traumatic Haemorrhage In Civilian Settings: A Narrative Literature Review), Celeste Marie Alfes

Faculty Scholarship

Introduzione: L’emorragia arteriosa è una delle principali cause di morte in ambito civile e militare. Nonostante la pressione manual diretta del sito emorragico sia ancora lo standard di riferimento per il controllo del sanguinamento, l’applicazione precoce, in ambito extra-ospedaliero di tourniquet si è dimostrata capace di ridurre le morti con bassi rischi di complicanze. L’obiettivo dello studio è quello di sintetizzare i metodi di utilizzo, le condizioni dei pazienti, gli esiti e le complicazioni relative alle applicazioni del tourniquet. Materiali e Metodi: È stata condotta una revisione narrativa della letteratura tramite PubMed. Risultati: Dieci articoli inclusi hanno fornito informazioni su …

Music And Exercise On Brain With Dementia, Claudio Otero Iii

Student Scholar Showcase

No abstract provided.

Tetralogy Of Fallot: A Clinical Review, Jacob Wooten, Joshua Bahos Silva

Student Scholar Showcase

Tetralogy of Fallot is a congenital heart disease that is associated with structural abnormalities during fetal development 1. The incidence of Tetralogy of Fallot in the United States is approximately 3-5 cases per 10,000 live births and is considered one of the most common cyanotic congenital heart diseases 2. The exact etiology of Tetralogy of Fallot is unknown, however it is thought to be associated with untreated maternal diabetes, maternal use of retinoids, as well as chromosomal abnormalities 2. The main components of this disease state include a right ventricular outflow obstruction, interventricular communication in the form of a ventricular …

Acoustic Changes During Passage Reading In Speakers With Parkinson's Disease, Kimberly C. Grubbs

LSU Master's Theses

Purpose: The purpose of this study was to evaluate speech changes in Parkinson’s disease (PD) while reading a passage, using both local (i.e., segment level) and global (i.e., utterance level) acoustic measures.

Methods: 20 speakers participated in the study (10 PD, 10 neurologically healthy controls). The speakers were asked to read The Caterpillar passage in a conversational mode. A total of five acoustic measures were included (local: vowel duration, Euclidean distance between corner vowels and schwa; global: articulation rate, F0/intensity range). These acoustic measures were compared between two sentences located in the two positions within the paragraph, initial and final. …

The Relationship Between The Development Of Communicative Functions In Children With Autism Spectrum Disorders, Isabelle Bankston

LSU Master's Theses

In regard to the assessment of language, it is difficult to determine exact communicative functions that are exhibited early in development that could indicate a prognostic value of verbal abilities and outcomes of children with autism spectrum disorder (ASD). The Verbal Behavioral Milestones Assessment and Placement Program (VB-MAPP, Sundberg, 2008) is frequently used in Applied Behavior Analysis for standard assessment procedures to measure development over time. The current study was designed to use the VB-MAPP to determine a relationship between certain communicative functions (i.e., mand, tact, listener responding, echoic, and intraverbal) that may suggest a correlation in growth in each …

Tradition, Rachel Gist

Reflections, Poetry, Photos, and other Writings

I wrote in hope that people could relate to the feelings I had during this time. Having Taylor time cut short is hard but also helped me to reflect and be even more grateful.

2020-04-08_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was captured from the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_99207---,00.html.

The website contained the table Count of Confirmed COVID-19 Cases by Date of Onset , sorted by Michigan Preparedness Region. It also contained 18 charts, including the count of confirmed Covid-19 cases by date of onset in the state overall as well as in each preparedness region,and the normalized rate of Covid-19 cases per 1,000,000 residents in both the state and in each preparedness region.

Copd Exacerbation Caused By Sars-Cov-2: A Case Report From The Louisville Covid-19 Surveillance Program, Forest W. Arnold, Kamran Mahmood, Angeline Prabhu, Darmaan Aden, Anupama Raghuram, Mark Burns, Leslie A. Beavin, Donghoon Chung, Kenneth E. Palmer, Julio A. Ramirez

The University of Louisville Journal of Respiratory Infections

A 53-year-old male with a history of chronic obstructive pulmonary disease (COPD) on home oxygen presented to the hospital with worsening shortness of breath plus cough. He was admitted to the intensive care unit for COPD exacerbation and respiratory failure. A routine evaluation was performed, including a nasopharyngeal swab for a respiratory viral panel, which was negative. His symptoms improved over 48 hours, after which time a surveillance test for SARS-CoV-2 returned as positive. After clinical improvement, he was discharged to home isolation.

How To Prevent Covid-19 In Nurses And Physicians In The Hospital Setting: Universal Test-And-Isolate For All Patients Admitted To Hospitals, Julio A. Ramirez, Ruth Carrico, Forest W. Arnold, Paul Schulz

The University of Louisville Journal of Respiratory Infections

No abstract provided.

New Campus Health And Safety Measures, April 8, 2020, University Of Northern Iowa

UNI Response to COVID-19

A memo staring that most campus buildings will be locked from April 10 until further notice, with further information for those employees that continue to come to campus.

2020-04-08_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Data About Places.
It contains aggregated data, self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.