Medicine and Health Sciences Commons^™

Working During Covid-19, Wku Staff Senate

Staff Council

Email from WKU Senate to WKU staff regarding working conditions during COVID-19.

Chronic Morphine Regulates Trpm8 Channels Via Mor-Pkcβ Signaling, Mircea Iftinca, Lilian Basso, Robyn Flynn, Charlie Kwok, Corinne Roland, Ahmed Hassan, Manon Defaye, Rithwik Ramachandran, Tuan Trang, Christophe Altier

Physiology and Pharmacology Publications

© 2020 The Author(s). Postoperative shivering and cold hypersensitivity are major side effects of acute and chronic opioid treatments respectively. TRPM8 is a cold and menthol-sensitive channel found in a subset of dorsal root ganglion (DRG) nociceptors. Deletion or inhibition of the TRPM8 channel was found to prevent the cold hyperalgesia induced by chronic administration of morphine. Here, we examined the mechanisms by which morphine was able to promote cold hypersensitivity in DRG neurons and transfected HEK cells. Mice daily injected with morphine for 5 days developed cold hyperalgesia. Treatment with morphine did not alter the expressions of cold sensitive …

Implementation Of Peer Support And Shared Decision-Making Aids For The Transcatheter Aortic Valve Replacement Population, Kimberlee Einfeld

Doctor of Nursing Practice Projects

Background: Patients at a community hospital verbalized fear, stress and anxiety about transcatheter aortic valve replacement (TAVR). Patients with aortic stenosis eligible for TAVR may experience low self-efficacy and anxiety while considering valve replacement which may lead to poor quality of life, interfere with understanding information from medical providers, and other health complications.

Methods: All patients eligible for TAVR between June and August of 2019 were invited to participate in a pilot project using peer support and use of shared decision-making (SDM) aids. Former TAVR patients were trained to be Mended Hearts TAVR peer volunteers. Participants were connected by telephone …

2020-04-14 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

2020-04-14 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Hannah Groves, Danielle Rivera, Rachel D. King, Estafania Montanez, Jolene Lobo, Samuel Anyona, Evans Raballah, Cristian Bologa, Andrew S. Rowland, Kristine Tollestrup, Tudor I. Oprea, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NMDOH county demographics online. NM emergency business loans. ABQ businesses violations. NM 5 new deaths 62 more cases. May 1 reopening too optimistic. MA contract tracing. Federal Ventilator Reserve. GM mass ventilator production. Ventilator-sharing device. $400M N-95 mask sterilization 60 sites. UNM PPE reprocessing online. Drug quality vulnerable. Managing urgent airway calls. Social distancing until 2022. SARS-Cov-2 blood supply. Contact tracing national blueprint. Mental health endangered. Successful surgical rapid response. Contact tracing medical ethics. Animal coronaviruses: human lessons. IDSA management guidelines. Ophthalmic practice. Pain management. Obstetrics management. Oncology practice. Forward triage. Scoring time-sensitive procedures. Outpatient structural heart disease. …

Biomimetic Gold Nanoshell-Loaded Macrophage For Photothermal Biomedicine, Sung Hun Kang, Yong Kyu Lee, Il Seok Park, In-Kyu Park, Seok Min Hong, Soon Young Kwon, Young Hee Choi, Steen J. Madsen, Henry Hirschberg, Seok Jin Hong

Integrated Health Sciences Faculty Research

The purpose of this study was to investigate the effect of photothermal treatment (PTT) with gold nanoshell (ANS) using a macrophage-mediated delivery system in a head and neck squamous cell carcinoma (HNSCC) cell line. To achieve this, ANS-loaded rat macrophages (ANS-MAs) were prepared via the coculture method with ANS. The human HNSCC (FaDu cell) and macrophage (rat macrophage; NR8383 cell) hybrid spheroid models were generated by the centrifugation method to determine the possibility of using ANS-MAs as a cancer therapy. These ANS-MAs were set into the tumor and macrophage hybrid spheroid model to measure PTT efficacy. Kinetic analysis of the …

Exploring Language Use Within A Parent-Mediated Intervention For Children Exhibiting Social Communication Difficulties, Emily Garza, Ashleigh Kellerman, Christi Masters, A.J. Schwichtenberg

Discovery Undergraduate Interdisciplinary Research Internship

For infants/toddlers experiencing social communication difficulties, parent-mediated interventions (PMI) are the current field standard to promote development within a natural context. Previous research highlights the importance for parents to scaffold language learning opportunities beyond clinical settings to maximize children’s potential. However, for infants/toddlers exhibiting social communication-based difficulties currently enrolled in a family routines-based PMI, less is known about the individual contributions of communication between child and parent in order to promote optimal language development.

The present study expands our understanding of children’s communication by examining whether (1)children exhibit language impairments at enrollment; (2)whether observed mother-child communication during play increases following …

2020-04-14_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was captured from the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_99207---,00.html.

The website contained the table Count of Confirmed COVID-19 Cases by Date of Onset , sorted by Michigan Preparedness Region. It also contained 18 charts, including the count of confirmed Covid-19 cases by date of onset in the state overall as well as in each preparedness region,and the normalized rate of Covid-19 cases per 1,000,000 residents in both the state and in each preparedness region.

"Mommy & Me" Constraint Therapy At Monroe Carell Jr. Children's Hospital At Vanderbilt, Logan Herndon

OTD Capstone Projects

Goals Of Experiential Component

• Develop advanced skills in clinical excellence, program development, leadership, and advocacy

• Provide resources for Vanderbilt to implement a CIMT program in the future

• Enact change in the Nashville community that benefits others through care, service, and social responsibilit

Promoting Physical Activity & Social Participation In Young Adults With Idd With Best Buddies, Belmont Chapter, Courtney Janusz

OTD Capstone Projects

Best Buddies is the largest international organization dedicated to end social, physical, and economic isolation among individuals with intellectual and developmental disabilities. Alongside of the Belmont Best Buddies president, we assessed the club’s specific needs and developed a sustainable field-day like event to promote engagement in physical activity and social participation. Much of the research found revolved around a lack of ability to engage and participate in these kinds of activities, which resulted in poor overall physical health. Also, research stated that participation in activities (similar to the one we want to create) is the context in which we form …

Potential Impacts Of Covid-19 On Individuals With Intellectual And Developmental Disability: A Call For Accurate Cause Of Death Reporting, Dalton Stevens, Scott D. Landes

Population Health Research Brief Series

Why might the COVID19 case fatality rate be higher among people with intellectual and development disabilities?

Auspicious Symbols Of Rank And Status, Byron Breedlove, Isaac Fung

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

Work published in Emerging Infectious Diseases.

Cold-Inducible Rna Binding Protein (Cirp) Impedes Proliferation And Inflammation In The Pymt Mouse Model For Breast Cancer, Daniel Albino Lujan

Biomedical Sciences ETDs

RNA binding proteins (RBPs) regulate gene expression by controlling mRNA export, translation, and stability. When altered, some RBPs allow cancer cells to grow, survive, and metastasize. Cold-inducible RNA binding protein (CIRP) is overexpressed in a subset of breast cancers, induces proliferation in breast cancer cell lines, and inhibits apoptosis. We generated a transgenic mouse model overexpressing human CIRP in the mammary epithelium to ask if it plays a role in mammary gland development. We also assessed the effects of CIRP on breast tumorigenesis using breeding crosses with the PyMT mouse model for breast cancer. CIRP decreased proliferation at the lactational …

Epigenomic Profiling Of Neuroblastoma Cell Lines., Kristen Upton, Apexa Modi, Khushbu Patel, Nathan M Kendsersky, Karina L Conkrite, Robyn T Sussman, Gregory P Way, Rebecca N Adams, Gregory I Sacks, Paolo Fortina, Sharon J Diskin, John M Maris, Jo Lynne Rokita

Kimmel Cancer Center Faculty Papers

Understanding the aberrant transcriptional landscape of neuroblastoma is necessary to provide insight to the underlying influences of the initiation, progression and persistence of this developmental cancer. Here, we present chromatin immunoprecipitation sequencing (ChIP-Seq) data for the oncogenic transcription factors, MYCN and MYC, as well as regulatory histone marks H3K4me1, H3K4me3, H3K27Ac, and H3K27me3 in ten commonly used human neuroblastoma-derived cell line models. In addition, for all of the profiled cell lines we provide ATAC-Seq as a measure of open chromatin. We validate specificity of global MYCN occupancy in MYCN amplified cell lines and functional redundancy of MYC occupancy in MYCN …

Understanding Stem Instructors’ Experiences With And Perceptions Of Deaf And Hard Of Hearing Students: The First Step Towards Increasing Access And Inclusivity, Makayla Long

Honors Theses

Through an anonymous survey we analyzed Western Michigan University (WMU) STEM instructors’ experience with and understanding of teaching and interacting with Deaf and Hard of Hearing (HoH) students. The goal of this study was to capture the experiences of WMU STEM instructors and the resources available to them given their direct impact on Deaf/HoH students’ ability to succeed and receive a post-secondary education. The findings of this study support the claim that instructors are not well supported or aware of the needs of Deaf/HoH students, and do not have access to adequate resources to resolve the issue.

The first steps …

Self-Disclosure Of Stuttering To Various Social Referent Groups And Its Relationships With Psychological Distress, Katrina Rourke

Honors Theses

Purpose: Research has shown that there are benefits associated with verbal disclosure of stuttering. However, most of the existing literature on stuttering disclosure has focused on how it affects listener perceptions of people who stutter, and little is known about speaker-focused outcomes of verbal stuttering disclosure. The purpose of the current study was to investigate who people who stutter verbally disclose to (e.g. friends, co-workers, neighbors) and if relationships between extent of disclosure and distress vary depending on the confidant’s social referent group. The seven social referent groups of focus were family, friends, romantic partners, people in the workplace, healthcare …

Novel Paclitaxel Nanoparticles For Enhanced Therapeutic Effects In Breast Cancer, Pallabita Chowdhury

Theses and Dissertations (ETD)

Drug delivery to triple negative breast cancer (TNBC) remains a formidable challenge. Given the lack of expressions of estrogen (ER), progesterone (PR) and human epidermal growth factor receptor (HER2), there is no specific prognostic marker for targeting this aggressive cancer. In spite of rapid advancement in breast cancer with agents such as Trastuzumab in HER2 positive, chemotherapy with cytotoxic agents remains the mainstay treatment for TNBC. Although these cytotoxic agents are potent in managing the tumor progression, yet they pose adverse effects on healthy tissues. Paclitaxel (PTX) has been used as a gold standard chemotherapeutic agent for breast, ovarian, pancreatic …

Structure And Stability Of W1/O/W2 Emulsions As Influenced By Wpc And Nacl In Inner Aqueous Phase, Vivek Prakash Wankhede, Prateek Sharma, Shaik Abdul Hussain, Ram Ran Bijoy Singh

Nutrition, Dietetics, and Food Sciences Faculty Publications

Effect of WPC and NaCl in internal aqueous phase (W1) of W1/O/W2 type double emulsions was studied. Pre-emulsion and final emulsion were prepared using microfluidizer and Ultra-Turrax high shear mixer, respectively. The emulsions prepared using salt exhibited uniform droplet size distribution and structural integrity. WPC at 6% and NaCl at 2 or 4% levels demonstrated better sedimentation stability (> 99%) and encapsulation stability (> 95%) during preparation and storage of double emulsions. Samples without added NaCl showed poor emulsion stability and structural integrity. Higher level of WPC i.e. 8% resulted in poor stability and encapsulation efficiency of double emulsions at …

Mental Health Inpatient Hospitalization: What Nursing Can Learn From "Sensory Rooms.", Haley Wilson

Honors Theses

The purpose of this undergraduate thesis is to explore the use of sensory rooms in the psychiatric inpatient care setting. Mental illness is a serious issue, affecting millions each year. In 2018 the Substance Abuse and Mental Health Services Administration (SAMHSA) reported that one in five, or 19.6% of U.S. adults experienced some form of mental illness. Inpatient hospitalization is limited to those individuals posing a risk for serious harm to themselves or others. A census conducted by SAMHSA on April 30th, 2018, indicated 129,115 patients in the U.S. were receiving mental health care treatment in the inpatient setting. An …

Gender And Socioeconomic Disparities In Iatrogenic In-Hospital Torsades De Points, Bradley Reinoehl

Honors Theses

It has been well established for decades that women are at increased risk for torsades de pointes (TdP). Additionally, it has been well documented that patients of lower socioeconomic status (SES) tend to have inferior health outcomes compared to other patient populations. In this study we investigate the incidence of iatrogenic in-hospital TdP among these two demographic groups. Iatrogenic in-hospital TdP is a complex combination of medical issues and including danger from QT prolonging medications. In theory, a combination of identifiable, demographic risk factors coupled with specific clinical settings could be used to identify patients at high risk for iatrogenic …

Evaluation Of Computer Aided Detection Of Tuberculosis On Chest Radiography Among People With Diabetes In Karachi Pakistan, Shifa Salman Habib, Sana Rafiq, Syed Mohammad Asad Zaidi, Rashida Abbas Ferrand, Jacob Creswell, Bram Van Ginneken, Wafa Zehra Jamal, Kiran Sohail Azeemi, Saira Khowaja, Aamir Khan

Community Health Sciences

Pakistan ranks fifth among high tuberculosis (TB) burden countries and also has seventh highest burden for diabetes mellitus (DM). DM increases the risk of developing TB and contributes to adverse TB treatment outcomes hence screening and integrated management for both diseases in high burden countries is suggested. Computer-Aided Detection for TB (CAD4TB) can potentially be used as triage tool in low resource settings to pre-screen individuals for Xpert MTB/RIF testing. The aim of this study was to evaluate the diagnostic accuracy and performance of CAD4TB software in people with diabetes (PWD) enrolled in a TB screening program in Karachi, Pakistan. …

School-Based Interventions To Promote Personal And Environmental Hygiene Practices Among Children In Pakistan: Protocol For A Mixed Methods Study, Nousheen Pradhan, Waliyah Mughis, Tazeen S. Ali, Maleeha Naseem, Rozina Karmaliani Professor

Community Health Sciences

Background: Poor personal hygiene and inadequate sanitation practices among young children leads to communicable diseases. There remains a gap in the holistic assessment of school children's hygiene literacy, practices and effectiveness of school-based hygiene interventions in Pakistan. Therefore, a school-based intervention protocol has been designed to promote personal and environmental hygiene practices for primary school children. Towards improving children's hygiene behaviors, the study will also focus on enhancing mothers' hygiene knowledge and practices.
Methods: Using quasi-experimental design with mixed methods data collection approaches, this study will be conducted in schools located in an urban squatter settlements in Pakistan. To assess …

A Validated Composite Organ And Hematologic Response Model For Early Assessment Of Treatment Outcomes In Light Chain Amyloidosis, Surbhi Sidana, Paolo Milani, Moritz Binder, Marco Basset, Nidhi Tandon, Andrea Foli, Angela Dispenzieri, Morie A Gertz, Suzanne R Hayman, Francis K Buadi, Martha Q Lacy, Prashant Kapoor, Nelson Leung, S Vincent Rajkumar, Giampaolo Merlini, Giovanni Palladini, Shaji K Kumar

Faculty, Staff and Student Publications

Newly diagnosed AL amyloidosis patients were evaluated to develop a model for early assessment of treatment benefit at 6 months, integrating both hematologic (HR) and organ response (OR) assessment (testing cohort, Mayo: n = 473; validation cohort, Pavia: n = 575). Multiple OR were assessed as follows: All OR (AOR): response in all organs, mixed OR (MOR): response in some organs, no OR (NOR)]. AOR rates at 6 months improved with deepening HR; complete response (CR; 38%, 35%), very good partial response (VGPR; 30%, 26%), and partial response (PR; 16%, 21%), respectively. A composite HR/OR (CHOR) model was developed using …

Virtual Visits For Care Of Patients With Heart Failure In The Era Of Covid-19: A Statement From The Heart Failure Society Of America, Eiran Z. Gorodeski

Faculty Scholarship

In response to the COVID-19 pandemic, US federal and state governments have implemented wide-ranging stay-at-home recommendations as a means to reduce spread of infection. As a consequence, many US healthcare systems and practices have curtailed ambulatory clinic visits—pillars of care for patients with heart failure (HF). In this context, synchronous audio/video interactions, also known as virtual visits (VVs), have emerged as an innovative and necessary alternative. This scientific statement outlines the benefits and challenges of VVs, enumerates changes in policy and reimbursement that have increased the feasibility of VVs during the COVID-19 era, describes platforms and models of care for …

Modulating The Rate Of Fibrin Formation And Clot Structure Attenuates Microvascular Thrombosis In Systemic Inflammation, Christian Valladolid, Marina Martinez-Vargas, Nitin Sekhar, Fong Lam, Cameron Brown, Timothy Palzkill, Alexander Tischer, Mathew Auton, K Vinod Vijayan, Rolando E Rumbaut, Trung C Nguyen, Miguel A Cruz

Faculty, Staff and Students Publications

Systemic inflammation can lead to coagulopathy and disseminated intravascular coagulation (DIC). In prior studies, the recombinant A2 domain of human von Willebrand factor (VWF; A2 protein) attenuated DIC and decreased mortality in lipopolysaccharide (LPS)-treated mice. Here, we performed studies to dissect the mechanism by which the A2 protein moderates DIC. We used confocal microscopy to analyze the fibrin clot structure in plasma from healthy humans and endotoxemic mice, turbidity assays to examine fibrin polymerization, and a murine model for LPS-induced DIC and introduced a loss-of-function mutation into the A2 protein for fibrin. The mutation of the residue E1567 located in …

Review Of Evidence Paper Practice And Patient Outcome Improvements Of Prescribing First-Line Antibiotics For Acute Uncomplicated Cystitis, Ira Amayun

DNP Qualifying Manuscripts

Abstract

Background: In 2017, the Centers for Disease Control and Prevention (CDC) published guidelines for treating acute uncomplicated cystitis (AUC) with nitrofurantoin (NTF), sulfamethoxazole-trimethoprim (SMX-TMP), or fosfomycin (FM) as appropriate first-line agents.

Objective: This paper aims to evaluate whether provider adherence to prescribing NTF, SMX-TMP, or FM has improved since the 2017 CDC guidelines were released, and to examine outcomes relative to use of prescribing guidelines in the treatment of AUC in non-pregnant women.

Methods: A literature review was conducted. The Cochrane Risk of Bias Tool was used to assess publication bias. The John Hopkins Research Evidence Appraisal Tool was …

Reducing Pressure Injuries In The Intensive Care Setting: Nursing Knowledge And Best Practices Approach, Michelle Harvey

Doctor of Nursing Practice Projects

Background: For many health care organizations, pressure injury (PI) prevention strategies have become a priority focus to improve patient outcomes and associated costs.

Problem: A rural community hospital located in the Eastern U.S. experienced an increase in hospital acquired pressure injuries (HAPIs), predominantly in the intensive care unit (ICU). In 2018, 17.4% of HAPIs occurred in the ICU.

Approach: Implementation of a Quality Improvement project in an adult ICU, providing education and on-going learning activities to nursing staff, and applying a standardized plan of care “bundle” for prevention interventions.

Outcomes: The approach resulted in improved documentation of flotation of heels, …

Covid-19 In The Rural South: A Perfect Storm Of Disease, Health Access, And Co-Morbidity, Anne Cafer, Meagen Rosenthal

APCRL Policy Briefs

No abstract provided.

Covid-19: Change Of Plans - A Photojournal, Tim Swanson

Reflections, Poetry, Photos, and other Writings

This photo journal was an assignment for one of my classes. From March 20 to April 12 I photographed scenes from my life as it now was due to the Coronavirus, and wrote statements reflecting on the context in which they were taken.

2020-04-13_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was captured from the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_99207---,00.html.

The website contained the table Count of Confirmed COVID-19 Cases by Date of Onset , sorted by Michigan Preparedness Region. It also contained 18 charts, including the count of confirmed Covid-19 cases by date of onset in the state overall as well as in each preparedness region,and the normalized rate of Covid-19 cases per 1,000,000 residents in both the state and in each preparedness region.