Medicine and Health Sciences Commons^™

2020-04-16_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was captured from the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_99207---,00.html.

The website contained the table Count of Confirmed COVID-19 Cases by Date of Onset , sorted by Michigan Preparedness Region. It also contained 18 charts, including the count of confirmed Covid-19 cases by date of onset in the state overall as well as in each preparedness region,and the normalized rate of Covid-19 cases per 1,000,000 residents in both the state and in each preparedness region.

Antibody Targeting Of B7-H4 Enhances The Immune Response In Urothelial Carcinoma., Joseph R Podojil, Alexander P Glaser, Dylan Baker, Elise T Courtois, Damiano Fantini, Yanni Yu, Valerie Eaton, Santhosh Sivajothi, Mingyi Chiang, Arighno Das, Kimberly A Mclaughlin, Paul Robson, Stephen D Miller, Joshua J Meeks

Faculty Research 2020

Patients with locally advanced and metastatic urothelial carcinoma have a low survival rate (median 15.7 months, 13.1-17.8), with only a 23% response rate to monotherapy treatment with anti-PDL1 checkpoint immunotherapy. To identify new therapeutic targets, we profiled the immune regulatory signatures during murine cancer development using the BBN carcinogen and identified an increase in the expression of the T cell inhibitory protein B7-H4 (VTCN1, B7S1, B7X). B7-H4 expression temporally correlated with decreased lymphocyte infiltration. While the increase in B7-H4 expression within the bladder by CD11b

2020-04-16_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., with COVID-19 results included as of 10 a.m.

Note on cumulative counts: This report is provisional and subject to change. As public health investigations of individual cases continue, there will be corrections to the status and details of referred cases that result in changes to this report.
Note on the deaths: Deaths must be reported by health care providers, medical examiners/coroners, and recorded by local health departments …

Bringing An Occupational Therapy Perspective To Linden Waldorf School, Morgan Craig

OTD Capstone Projects

Through this project, an occupational therapy doctoral student brought an occupational therapy perspective to Linden Waldorf School and provided the school with direct observations, educational presentations, and various educational materials on the topics of fine motor development, sensory processing, and behavior management in order to help empower Waldorf faculty and staff to best meet the needs of their students.

Increasing Participation In Children And Adults With Disabilities At Christ Presbyterian Church, Taylor Boggus

OTD Capstone Projects

In partnering with Christ Presbyterian Church’s Special Needs Ministry for my doctoral capstone project, my aim was to increase participation in the community for children and adults with disabilities. I first created a family needs questionnaire to enable the special needs ministry to identify the needs of the families they serve. I created a resource guide for the ministry to disseminate to their families that includes local resources that serve children and adults with disabilities, including information about the services each resource provides and their contact information. Finally, I created a job skills curriculum to be used in the ministry’s …

2020 - The Twenty-Fourth Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Twenty-fourth Annual Symposium of Student Scholars, held on April 16, 2020. Includes abstracts from the presentations and posters.

2020-04-16 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Hannah Groves, Estefania Montanez, Rachel D. Montanez, Elly Munde, Perez Olewe, Cristian Bologa, Gregory Mertz, Kristine Tollestrup, Andrew S. Rowland, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

Daily NM recap. Public Catholic masses resume. Chaplains stand down. Food delivered to tribal communities. Governors order face coverings use. Campfires restricted. NY hospitalizations fall. Nursing home probe in NJ. GOP call WHO Chief resignation. Africa cases up 51% and deaths up 60%. Sub-Saharan Africa prediction. Resurgence in Japan. UK conditions to reopen. France deaths up. UNMH protests over PPE. Med center financial stress. Hospitals bailout insufficient. 55% US healthcare worker cases hospital spread. Cruise ship transmission. Essential contact tracing. JAMA editors discuss policy. Guideline updates: treatment, emergency dep, ophthalmology, cath lab, telemedicine, liver disease, caregiver, health care …

On Site Home Assessments For Individuals With Disabilities, Lacy Roling

OTD Capstone Projects

A poster presentation of a completed experiential component with Tucker's House.

Visual Aids For Nashville Dolphins, Sally Widmann

OTD Capstone Projects

A creation of visual aids and an E-manual for beahvioral strategies to assist the coaches and volunteers with work with the Nashville Dolphins organization. The goal of this project was to increase participation of swimmers, who are made up of adults and children alike with a large spectrum of disabilities.

Lymphatouch™ As A Preparatory Method For Chemo-Induced Peripheral Neuropathy And Radiation-Induced Fibrosis: A Case Study, Abigail Harris

OTD Capstone Projects

Quality Improvement: Aims to explore the ability to expand the services offered at the Nashville Breast Center and potentially provide improved health-related quality of life for patients in the survivorship stage of breast cancer. Case Study: To assess the LymphaTouch ™ device for use in treating Chemo-Induced Peripheral Neuropathy and Radiation-Induced Fibrosis.

Supporting Older Adults Through Aging In Place And Capable Programs, Laura Compton

OTD Capstone Projects

This experiential component or doctoral capstone project involved a partnership with Habitat for Humanity of Greater Memphis. Through this agency, projects were completed based on identified needs of the Aging in Place and CAPABLE programs. The Aging in Place (AIP) program provides critical home repairs to low-income adults aged 60 years and older. The CAPABLE program provides the same critical home repairs along with a select number of visits from a registered nurse and an occupational therapist to help the older adults age in place safely.

Clinical Support: An Unconventional Request – Providence’S 100 Million Masks Initiative, Carrie Grinstead, Heather J. Martin, Laurie Schwing (Ed.)

Articles, Abstracts, and Reports

In early March, Seattle, WA, was the epicenter of the US COVID-19 pandemic. Providence St. Joseph Health had seen the first reported US case of COVID-19 on January 20 [1] and quickly found itself responding to a growing crisis, with little information about how best to care for patients while protecting frontline staff.

On March 16, 2020, Providence System Library Services received an email from senior leadership with the subject line: “Urgent – An Unconventional Request.” We were asked to pause all other work to search for viable mask patterns that could be easily and quickly made at home by …

Awareness Regarding Causes Of Infertility Among Out-Patients At A Tertiary Care Hospital In Karachi, Pakistan, Hamza M. Ahmed, Mohammad Khan, Farah Yasmin, Haris Jawaid, Hiba Khalid, Anum Shigri, Faryal Nawaz, Choudhary A. Hasan

Section of Internal Medicine

Introduction: Infertility is the inability of a couple to achieve pregnancy within 12 months of sexual intercourse without the use of contraceptives. The Pakistani population, belonging to a low-middle income country, has a high prevalence of infertility due to a low knowledge and awareness regarding its causes, and lack of healthcare-seeking behavior for this medical issue. The prevalence of infertility in Pakistan is reported as 22%, with primary infertility accounting for 4% of the total cases. This leads to psychological trauma among women as societal norms equate infertility with failure on a personal, emotional, and social level. In this study, …

Dynamics Of Larkspur (Delphinium Barbeyi) Pellet Consumption And Tolerance Of The Inhibitory Effects Of Larkspur Alkaloids On Muscle Function In Cattle., Benedict T. Green, Jim Pfister, Dale Gardner, Kevin Welch, Daniel Cook

Poisonous Plant Research (PPR)

Larkspurs (Delphinium spp.) are toxic native plants on foothill and mountain rangelands in western North America, which poison cattle grazing on those rangelands. The purpose of this study was to examine in a laboratory setting, the subclinical effects of larkspur intake and toxicosis, by allowing larkspur susceptible and resistant cattle to self-select the amount of larkspur consumed in pellet form. We hypothesized that there would be differences in short term (9 – 11 day) pellet consumption between susceptible and resistant animals. Two trials were completed, each with larkspur resistant and susceptible Angus steers, and larkspur-alfalfa pellets at a 12% …

Evaluating Fitness-To-Drive Among Individuals With Sensory Deficits: A Retrospective Chart Review, Caroline Clark

OTD Capstone Projects

Objective: To explore the diagnostic validity of clinical assessments for sensation in determining fitness-to-drive recommendations in active drivers with sensory deficits.

Methods: Retrospective chart review was conducted using a purposive sampling approach of patients’ medical records from the Vanderbilt Driver Evaluation and Rehabilitation Program in Nashville, Tennessee. Medical records for patients assessed from 12/01/2017 through 12/31/2019, ages 18 or older, with lower extremity sensory deficit(s) identified in the referring and/or treatment diagnoses, medical history, and/or the occupational therapy evaluation problem list were eligible for review. A total of 288 patient medical records were reviewed, but only 40 patient medical …

Nurses For Newborns – Incorporating An Occupational Therapy Perspective In Its Work With Women And Families In The Perinatal Period, Lynsey Beros

OTD Capstone Projects

The author partnered with a nonprofit organization, Nurses for Newborns, to incorporate an occupational therapy perspective in its work with women and families in the perinatal period as part of the OTD capstone project.

The Impact Of Vaccine Coverage And Exemptions On The Resurgence Of Vaccine Preventable Disease: A Review Of The Literature, Kara Costantino

Honors Theses

Vaccinations are a safe and effective way to prevent the spread of disease. In recent years, vaccine coverage rates have declined while nonmedical exemption rates have increased. These changes have contributed to increased prevalence of vaccine preventable diseases. Declining vaccine coverage and increasing nonmedical exemptions are a threat to public health and the relationship between these factors needs to be understood. Clusters and outbreaks of vaccine preventable diseases have occurred as a result of more people declining vaccination. Factors that may incline someone to refuse vaccination include safety concerns, lack of trust, freedom of choice, decreased understanding for the need, …

The Use Of A Visual Motor Test To Identify Lingering Deficits In Concussed Collegiate Athletes, Katherine J. Hunzinger, Erik W. Sanders, Horace E. Deal, Jody L. Langdon, Kelsey M. Evans, Brandy A. Clouse, Barry Munkasy, Thomas A. Buckley

Health Sciences & Kinesiology: Faculty Publications

Background:

Emerging evidence suggests neurophysiological deficits, such as visual motor coordination (VMC), may persist beyond clinical concussion recovery. Instrumented measurement of upper-limb VMC is critical for neurological evaluation post-concussion and may identify persistent deficits further elucidating persistent neurophysiological impairments not detected by the current clinical assessment battery.

Aim:

The aim of the study was to determine if a VMC test identifies persistent deficits in concussed collegiate student-athletes who have returned to baseline on clinical concussion assessments.

Methods:

Thirteen recently concussed intercollegiate student-athletes (male: 7, 18.9±0.7 years, 175.5±12.4 cm, 75.5±23.2 kg), and 13 matched control student-athletes (male: 7, 19.3±1.1 years, 173.5±11.9 …

Natural History Of Non-Lethal Raine Syndrome During Childhood, Chiara Mameli, Giulia Zichichi, Nasim Mahmood, Siham Chafai Elalaoui, Adnan Mirza, Poonam Dharmaraj, Marco Burrone, Elisa Cattaneo, Jayesh Sheth, Ajit Gandhi

Department of Paediatrics and Child Health

Background: Raine syndrome (RS) is a rare autosomal recessive disorder caused by biallelic loss-of-function mutations of FAM20C. The most common clinical features are microcephaly, exophthalmos, hypoplastic nose and severe midface hypoplasia, leading to choanal atresia. The radiological findings include generalized osteosclerosis and brain calcifications. RS is usually lethal during the neonatal period due to severe respiratory distress. However, there exists a non-lethal RS form, the phenotype of which is extremely heterogeneous. There is paucity of data about clinical course and life expectancy of these patients.
Results: This is the first description of follow-up features of non-lethal RS patients. Moreover, we …

University Confirms First Case Of Covid-19, April 16, 2020, University Of Northern Iowa

UNI Response to COVID-19

A memo from the President informing the campus that for the first time, an employee had self-reported that they have COVID-19.

Insights From Immuno-Oncology: The Society For Immunotherapy Of Cancer Statement On Access To Il-6-Targeting Therapies For Covid-19., Paolo Antonio Ascierto, Bernard Fox, Walter Urba, Ana Carrizosa Anderson, Michael B Atkins, Ernest C Borden, Julie Brahmer, Lisa H Butterfield, Alessandra Cesano, Daniel Chen, Tanja De Gruijl, Robert O Dillman, Charles G Drake, Leisha A Emens, Thomas F Gajewski, James L Gulley, F Stephen Hodi, Patrick Hwu, David Kaufman, Howard Kaufman, Michael Lotze, Douglas G Mcneel, Kim Margolin, Francesco Marincola, Michael J Mastrangelo, Marcela V Maus, David R Parkinson, Pedro J Romero, Paul M Sondel, Stefani Spranger, Mario Sznol, George J Weiner, Jon M Wiggington, Jeffrey S Weber

Department of Microbiology and Immunology Faculty Papers

No abstract provided.

Rna-Induced Conformational Switching And Clustering Of G3bp Drive Stress Granule Assembly By Condensation, Jordina Guillén-Boixet, Alex S. Holehouse, Rohit V. Pappu, Et Al.

2020-Current year OA Pubs

Stressed cells shut down translation, release mRNA molecules from polysomes, and form stress granules (SGs) via a network of interactions that involve G3BP. Here we focus on the mechanistic underpinnings of SG assembly. We show that, under non-stress conditions, G3BP adopts a compact auto-inhibited state stabilized by electrostatic intramolecular interactions between the intrinsically disordered acidic tracts and the positively charged arginine-rich region. Upon release from polysomes, unfolded mRNAs outcompete G3BP auto-inhibitory interactions, engendering a conformational transition that facilitates clustering of G3BP through protein-RNA interactions. Subsequent physical crosslinking of G3BP clusters drives RNA molecules into networked RNA/protein condensates. We show that …

Seeking Care At Free Episodic Health Care Clinics In Appalachia, Malerie Lazar, Sandra Thomas, Lisa Davenport

Journal of Appalachian Health

Background: People who live in rural Appalachia experience a wide variety of problems when seeking access to health care. Health care disparities continue to be one of the most complex and prevalent problems, and many barriers exist for impoverished men and women such as a lack of education, complications with health insurance, and personal distrust of healthcare providers.

Purpose: A critical gap in the literature is the unheard voice of persons in rural underserved areas. The purpose of this study was to explore the perspectives of persons in rural Appalachia who seek healthcare services at free episodic health care clinics, …

Skin Cancer And Uv Exposure-Related Behaviors Among Appalachian And Non-Appalachian Adults, Minal Patel, Katrina Serrano, Elise Rice, Chan Thai, Kelly Blake, Robin C. Vanderpool

Journal of Appalachian Health

Introduction: Appalachian communities experience elevated rates of cancer incidence and mortality relative to other regions in the U.S. Specifically, melanoma mortality rates are higher in Appalachia compared to the national average, despite comparable incidence rates.

Purpose: To examine differences in self-reported history of skin cancer and prevalence of two UV exposure behaviors between Appalachian and non-Appalachian adults in a nationally representative sample.

Methods: Data are from four cross-sectional cycles of the Health Information National Trends Survey (2011–2014) (N=14,451). We examined sunscreen use and tanning bed use, and self-reported history of melanoma and non-melanoma skin cancer. Descriptive and weighted …

Impact Of The Affordable Care Act On Referral To Care For People Living With Hiv In Appalachia, Cameron A. Wade, Timothy N. Crawford, Nicole Leedy, Alice C. Thornton

Journal of Appalachian Health

Introduction: The Affordable Care Act (ACA) enacted on March 23, 2010 significantly impacted access to healthcare for people living with HIV (PLWH). Expansion of care was accomplished in three areas: eliminating exclusions for pre-existing conditions, elimination of lifetime caps on healthcare expenditures, and expansion of Medicaid eligibility.

Purpose: This study evaluated the impact of state implementation of the ACA Medicaid expansion on referral to HIV care at a Ryan White federally funded clinic in Kentucky (University of Kentucky Bluegrass Care Clinic [UK BCC]).

Methods: Retrospective chart review of all newly enrolled patients at the UK BCC between March 2010 and …

Food Insecurity Among College Students With And Without Medical Disorders At A University In Appalachia, Laura Mcarthur, Melissa D. Gutschall, Kimberly Fasczewski, Anna Jackson

Journal of Appalachian Health

Objective: This study compared severity of food insecurity, characteristics, and behaviors of college students with and without diagnosed medical disorders.

Design: Data were collected using a cross-sectional online questionnaire. Variables measured were food security status, disorders, coping strategies, and perceived barriers to food access. Descriptive and inferential statistics examined associations and compared groups. Statistical significance was p≤0.05.

Setting: Data were collected at Appalachian State University in North Carolina.

Participants: The sample was 247 food insecure students, of whom 60% were females, 50% 3rd- and 4th-year students, and 75% whites.

Results: Medical disorders were reported by 67.2% of food insecure students, …

A Nutritional And Environmental Analysis Of Local Food Pantries Accessible To College Students In Rural North Carolina, Emily E. Frymark, Jonathon Stickford, Alisha Farris

Journal of Appalachian Health

Introduction: Food insecurity is a growing concern among college students and is especially prevalent in rural areas. Food pantries often serve as a resource to food insecure individuals yet, their policies, standards, and nutritional quality vary due to the unpredictability of food donations.

Purpose: To examine the nutritional quality of food items and adherence of best practices at local food pantries accessible to college students near a university in rural Appalachia.

Methods: Three food pantries in North Carolina were selected due to their proximity to a local, rural university. Food items were analyzed for nutrient and food …

Use And Perceptions Of A Campus Food Pantry Among Food Insecure College Students: An Exploratory Study From Appalachia, Laura Mcarthur, Kimberly S. Fasczewski, Alisha Farris, Miranda R. Petrone

Journal of Appalachian Health

Introduction: Food insecurity has emerged as a public health problem among college students in Appalachia, jeopardizing their physical, mental, and emotional health and academic success. Campus food pantries have been established in this region, but no data are available concerning student use or perception of services.

Purpose: This study measured use and perceptions of a campus food pantry by students at a mid-sized university in rural North Carolina.

Methods: An online questionnaire collected behavioral and perceptual data, and follow-up interviews explored these variables. Descriptive statistics with significance at p<0.05 and thematic analytical procedures were used.

Results: Questionnaires were submitted by 896 of 6000 recruited students (14.9%), …

The Need For Evidence-Based Interventions To Reduce Food Insecurity Among College Students, Sarah Brothers, Stephanie Jilcott-Pitts Phd

Journal of Appalachian Health

Food insecurity is defined as insufficient resources to meet food needs. This is a global problem but is not confined to those countries identified as poor. One group of Americans who are particularly affected, and for whom the effects are particularly severe, is college students.

Antidepressants Versus Music Therapy: Which Treatment Is Better For Treating Depression In Parkinson's Disease?, Emaan Dawood

Virginias Collegiate Honors Council Conference

Music and medicine are merging to treat depression in Parkinson’s disease (PD). Antidepressants, the current standard, demonstrate mixed effects in clinical trials, warranting other treatment options. Here, I compare music therapy to antidepressants in the treatment of depression in PD via literature review. Studies of depressed PD patients undergoing music therapy and/or antidepressants were reviewed with attention to variables including depression (on a patient-reported outcome) that were measured pre- and post- therapy. In the music studies, improvements were seen in depression. Methodological inconsistencies across these studies, a paucity of studies, and small sample sizes, however, necessitate more research to reach …