Medicine and Health Sciences Commons^™

Emg Analysis Of Latissimus Dorsi, Middle Trapezius, And Erector Spinae Muscle Activity During Return To Neutral Phase Of Spinal Rotation, Stephen Erlandson, Nathan Hasunuma, Landon Uetz

Physical Therapy Scholarly Projects

Purpose/Hypothesis: Rotation of the spine is a common movement used to perform activities of daily living and sports performance, and contributes to a large percentage of low back injuries. Performance of spinal rotation for the rehabilitation and prevention of future back injuries should be considered, as low back pain is the second most common reason for a physician visit. Muscles that are involved in rotation of the spine have been studied, but the Latissimus Dorsi (LD) has limited research on the influence of spinal rotation. The LD muscle is one of the largest back muscles and influences many movements of …

The Collaboration Of Music Therapy And Physical Therapy: A Case Study For Rehabilitation Treatment Of A Patient With Chronic Stroke, Kaci Hemmesch, Taylor Kunz

Physical Therapy Scholarly Projects

Background and Purpose: Strokes are the fifth leading cause of death in the United States and nearly 800,000 people suffered from a stroke last year alone. Even though two-thirds of those people had survived, many of the survivors were left with a number of activity limitations and participation restrictions. The research is extensive in the realm of physical therapy interventions and how it can help with those disabilities, but truly lacks the knowledge behind the effects of a collaboration of music therapy with physical therapy.

Case Description: This case study follows an 85-year-old woman with lasting chronic impairments from a …

The Effect Of Barefoot Running On Navicular And Pelvic Drop: A Randomized Controlled Trial, Sarah Bunde, Christopher James, Kathryn West

Physical Therapy Scholarly Projects

Background and Purpose: Gaining knowledge of the change in navicular drop of the foot and pelvic movement in response to barefoot running training may allow sports medicine professionals, coaches, athletes, and others in the healthcare field to decrease the amount of injuries that may be caused by these motions. The effects of rearfoot strike pattern (RFSP) versus a forefoot strike pattern (FFSP) in determining the impact on navicular drop and pelvic movement is lacking in literature. Due to the increased correlation of hip movement and lower extremity injuries, the purpose of this study was to determine if barefoot running with …

The Effectiveness Of A 7-Week Fall Prevention Program For Community Dwelling Older Adults, Karlee Mccloud, Kayla Sendelbach

Physical Therapy Scholarly Projects

Background: Every year millions of adults over the age of 65 experience a fall. Falls cost healthcare and individuals financial distress, decrease self-confidence, and can cause injuries. Balance and strength deficits contribute to increasing an individual's fall risk. Studies have shown the efficiency of community-based exercise and education programs on reducing the risk of falling. The Stepping On Program utilizes a group setting to educate on falls and risks, strength and balance exercises, home safety, vision, coping after a fall, and community mobility. Stepping On is an evidence-based fall prevention program that has been proven to reduce falls by 31 …

Physical Therapy Rehabilitation Following A Thoracic To Sacroiliac Spinal Fusion: A Case Report, Ragen Wilson

Physical Therapy Scholarly Projects

Background and Purpose. This case study described the 9 week outpatient physical therapy rehabilitation process of a 75 year old female following a posterior thoracic spine (T9) to sacroiliac (S 1) spinal fusion as a result of adult degenerative scoliosis and prolonged back pain (Type 1 ). The purpose of this case report was to describe the overall outpatient physical therapy management of this post-operative fusion.

Description. The patient presented to physical therapy with decreased mobility, decreased function, decreased balance, lower extremity strength deficits, pain, and loss of independence.

Intervention. Initially, treatment occurred in a therapeutic pool and then progressed …

A Look Into The Impacts Of Tele-Optometry Expansion, Anna Hulsey

Honors Theses

Objective This study aims to assess the health and economic costs and benefits to society and patients resulting from the expansion of telemedicine into online refractive exams and to determine the likelihood of potential consumers to utilize such services. Methods A paper survey was distributed at the Inaugural Cempa Health Fair in October of 2019 to both vendors and participants. 105 responses were used to evaluate personal perceptions, practices, and likelihood across a diverse range of demographics. Responses were then entered and analyzed using descriptive statistics and percentages/frequencies. Results Results showed respondents were most attracted to online refractive exams due …

Analysis Of The Soil Lead Contamination Issue Of South Chattanooga, Tesros Cherian

Honors Theses

Childhood lead poisoning is an ongoing health threat despite actions taken by governmental bodies to remove lead from gasoline, paint, and other various household objects in which lead is found. In South Chattanooga specifically, lead has been found in the soil at such a level it is considered a public health threat, especially to children under the age of six. This situation has caused the Environmental Protection Agency (EPA) to name the South Chattanooga area as a Superfund site known as the Southside Chattanooga Lead Superfund site. This designation has resulted in multiple community meetings between EPA officials and Chattanooga …

“A Moral Imperative To Prevent Aids”: Race And Religion In Atlanta’S Aids Activism, 1981-1993, Madison Bailey

Honors Theses

The early years of the AIDS epidemic marked a tumultuous period of American history, calling into question the authority of doctors and the ability of scientists to cure disease. Already marginalized groups, such as gay men and intravenous drug users, appeared to be most vulnerable to a deadly virus with no cure or effective treatments. In the face of discrimination, activists rose up to provide necessary services for AIDS patients and advocate on their behalf. This activism uniquely characterized the early AIDS epidemic and permanently changed the field of biomedical research. The current historiography of AIDS activism tends to focus …

The Role Of Dopamine In Decision Making Processes In Drosophila Melanogaster, Michelle C. Bowers

Undergraduate Honors Theses

Understanding the neural processes that mediate decision making is a relatively new field of investigation in the scientific community. With the ultimate goal of understanding how humans decide between one path and another, simpler models such as Drosophila Melanogaster, the common fruit fly, are often utilized as a way of determining the neural circuits involved in these decision-making processes. One of the most important decisions flies make is the decision of where to lay their eggs (oviposit). Choosing the proper substrate upon which to lay eggs is a crucial decision that can ultimately impact their fecundity. This paper investigates the …

Perceptions Of Risk For Stress Fractures: A Qualitative Study Of Female Runners With And Without Stress Fracture Histories., Therese E Johnston, Jeremy Close, Phil Jamora, Susan F Wainwright

Department of Physical Therapy Faculty Papers

OBJECTIVES: To gain insight into perceived factors related to bone health and stress fracture (SF) prevention for female runners and to understand their experiences within the medical community.

DESIGN: Cohort qualitative study.

SETTING: University health system.

PARTICIPANTS: Forty female runners, 20 who had SF histories and 20 age-and-running-distance matched women without SF.

MAIN OUTCOME MEASURES: Women participated in audiotaped qualitative semi-structured interviews. For women with a SF history, questions sought their perspectives on factors that they felt contributed to SF, experiences with the medical community, and changes made post SF. For women without a SF history, questions sought perspectives on …

Factors Associated With Quality Of Life And Dialysis Compliance, Viviana Garcia Guerra

Theses and Dissertations

This dissertation study explored the relationship between quality of life (QoL) and dialysis compliance with family support, spirituality, age, gender, and socioeconomic status (SES) among people with end stage renal disease (ESRD). Utilizing the Biopsychosocial Spiritual Framework, this study pursued to inform mental health professionals working with people undergoing dialysis about the factors that influence QoL and dialysis compliance. This descriptive quantitative dissertation study included 79 participants who self-identified as persons receiving either hemodialysis or peritoneal dialysis. Participants were members from closed social online forums and the National Kidney Foundation.

The current study found that family support and SES predicted …

Mathematical Modeling Of Nonlinear Dynamics Of Blood Hormones On The Regulatory System, Gabriela Urbina

Theses and Dissertations

We study a mathematical modeling of nonlinear dynamics of blood hormones, which includes glucose and insulin. On Chapter I, II, III and IV, we introduce this work, analyze an effect of the secreted insulin by the pancreatic beta cells and glucagon hormones and state concluding remarks, respectively. This model considers the time evolution of nonlinear dynamics of the equations for glucose, glucagon and insulin concentrations plus insulin and glucagon actions and the secreted insulin as a result of elevation of glucose in the blood plasma. Using both analytical and numerical procedures, we determine such quantities using different parameters for different …

An Evaluation Of The Eating Behaviors Of Honors College Undergraduate Students At The University Of Mississippi, Anna Bouthillier

Honors Theses

Eating disorders are defined as an illness that changes one’s relationship with food, that ultimately affects one’s emotions, thoughts, and physical well-being. Three types of eating disorders most commonly diagnosed are anorexia nervosa, bulimia nervosa, and disordered eating. It is important to note that disordered eating is a term used to describe abnormal eating behaviors and feelings related to food that may or may not fall into a certain diagnostic category (Anderson, 2018). Many college students today are diagnosed with an eating disorder or disordered eating as a result of the increasing anxiety and pressures experienced at this age.

The …

Variability In State Regulations Pertaining To Infection Control And Pandemic Response In Us Assisted Living Communities, Taylor Bucy, Lindsey Smith, Paula C. Carder, Jaclyn Winfree, Kali Thomas

OHSU-PSU School of Public Health Faculty Publications and Presentations

At the end of 2019, international attention was drawn to an outbreak of zoonotic coronavirus SARS-CoV-2, formally named COVID-19, in Wuhan, China. The World Health Organization officially declared the outbreak a global pandemic on March 11, 2020, with the United States recording >1600 confirmed and presumptive travel-related and community-acquired cases at that time. As of April 10, 2020, all 50 US states and the District of Columbia, have reported cases, with the total number of US cases now totaling >400,000.2 Seattle, WA, is the US epicenter, with nursing facilities experiencing the greatest number of fatalities. Because of the communal living …

Discoidin Domain Receptor 1 Functionally Interacts With The Igf-I System In Bladder Cancer, Simone Buraschi, Alaide Morcavallo, Thomas Neill, Manuela Stefanello, Chiara Palladino, Shi-Qiong Xu, Antonino Belfiore, Renato V. Iozzo, Andrea Morrione

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

No abstract provided.

Catabolic Degradation Of Endothelial Vegfa Via Autophagy, Thomas Neill, Carolyn Chen, Simone Buraschi, Renato V. Iozzo

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Extracellular matrix-evoked angiostasis and autophagy within the tumor microenvironment represent two critical, but unconnected, functions of the small leucine-rich proteoglycan, decorin. Acting as a partial agonist of vascular endothelial growth factor 2 (VEGFR2), soluble decorin signals via the energy sensing protein, AMP-activated protein kinase (AMPK), in the autophagic degradation of intracellular vascular endothelial growth factor A (VEGFA). Here, we discovered that soluble decorin evokes intracellular catabolism of endothelial VEGFA that is mechanistically independent of mTOR, but requires an autophagic regulator, paternally expressed gene 3 (PEG3). We found that administration of autophagic inhibitors such as chloroquine or bafilomycin A1, or depletion …

Parent Perception Of Effectiveness Of Educational Materials, Rachel Conti, Youstina Gerges, Amy Gladis, Amanda Off, Lauren Paxton, Jerret Schunk, Susan Ronan

Annual SHSP Student Research and Scholarship Day

No abstract provided.

Barriers To Parent-Child Sex Communication: Exploring The Perspective Parents With Gay, Bisexual, And Queer Adolescent Sons., Maikel Mansour, Angela Allen, Idelys Amador, Carolina Cortes, Alaina Cottrell, James Goodman, Lady Henriquez, Zanib Iqbal, Nicole Kashine, Mary Kovoor, Halima Mohammed-Bashiru, Amanda Moody, Racquel O’Connor, Ludween Pierre, Nicole Scambia, Cathy Yu, Keosha Bond

Annual SHSP Student Research and Scholarship Day

No abstract provided.

Pregnancy Outcomes And Documentation Status Among Latina Women: A Systematic Review, Dawn M. Richardson, Sarah B. Andrea, Amber Ziring, Cassandra Robinson, Lynne Messer

OHSU-PSU School of Public Health Faculty Publications and Presentations

Purpose: The impression that Latinas experience paradoxically good pregnancy outcomes in the United States persists, despite evidence showing that these outcomes are not enjoyed by all Latina subgroups. We conducted this systematic literature review to examine the relationship between documentation status and pregnancy outcomes among Latinas.

Methods: This review synthesizes empirical evidence on this relationship; examines how these studies define and operationalize documentation status; and makes recommendations of how a more comprehensive methodological approach can guide public health research on the impact of documentation status on Latina immigrants to the United States. We searched the literature within PubMed, …

Investigating The Interactions Between Individual Calmodulin And Hiv-1 Protein Domains, Riley K. Kendall, Jerry Larue

Student Scholar Symposium Abstracts and Posters

The World Health Organization found that 37.9 million people were living with HIV by the end of 2018. HIV is a virus that weakens the immune system through viral replication and the destruction of CD4⁺ T-cells, which are white blood cells that detect infection and make antibodies. A cure for HIV has not yet been discovered. HIV-1 contains a Gag polyprotein which regulates the stages of viral replication. Previous studies suggest that the myristoyl group of a matrix protein peptide found on the Gag polyprotein, MA, forms a complex with a calcium-binding, multifunctional regulatory protein called Calmodulin (CaM). CaM …

A Reinforcement Learning Based Control Approach For Propofol-Induced Burst Suppression, Jason C. Huang, Scott C. Tadler, Brian J. Mickey, Keith Jones

Utah Space Grant Consortium

High-dose propofol is being investigated for its potential antidepressant effect. Propofol is titrated to induce burst suppression, a specific EEG pattern. However, propofol is difficult to dose due to uncertainty in each patient’s pharmacokinetics (PK) and pharmacodynamics (PD), and the lack of a commercially available monitor of propofol concentration. Clinicians currently infer the proper drug dose after observing the EEG response to the given dose. In this report we share our development of an automated controller to optimally administer propofol-induced burst suppression. We designed a deep deterministic policy gradient (DDPG) algorithm, which includes two deep neural networks and relates a …

Case Presentation On Periampullary Cancer And Ampullectomy, Tetiana Soloviova

Publications and Research

Periampullary cancer is a complex disease of heterogenous origin. This is cancer arising within 2 cm of the papilla of Vater and includes pancreatic, ampullary, biliary and duodenal cancers. Duodenal cancer has the highest estimated 5-year survival (49%), followed by ampullary cancer (45%), distal bile duct cancer (27%), and pancreatic cancer (18%). (Ray-Offor, 2019, ¶ 1)

The Moderating Effect Of Social Support On The Impact Of Perceived Loneliness On The Mental Health Of Long-Term Care Nursing Home Residents, Lindsay Nicole Stivers

Electronic Theses and Dissertations

The purpose of the present study is to examine the moderating effect of social support on the impact of loneliness on anxiety and depression in long-term care residents in nursing homes. Recent research suggests that a relationship exists between loneliness and rates of depression and anxiety in long-term care nursing home residents. The present study seeks to examine the buffering effect of social support and utilize the findings to provide suggestions for policy, practice, and research. A binary logistic regression and a series of multiple linear regressions were conducted to examine the relationships between the variables. The present study’s sample …

Heterodimeric Il-15 Delays Tumor Growth And Promotes Intratumoral Ctl And Dendritic Cell Accumulation By A Cytokine Network Involving Xcl1, Ifn-Γ, Cxcl9 And Cxcl10., Cristina Bergamaschi, Hrishikesh Pandit, Bethany A Nagy, Dimitris Stellas, Shawn M. Jensen, Jenifer Bear, Maggie Cam, Antonio Valentin, Bernard A Fox, Barbara K Felber, George N Pavlakis

Articles, Abstracts, and Reports

BACKGROUND: Interleukin-15 (IL-15) promotes growth and activation of cytotoxic CD8

METHODS: The antitumor activity of hetIL-15 produced from mammalian cells was tested in mouse tumor models (MC38 colon carcinoma and TC-1 epithelial carcinoma). The functional diversity of the immune infiltrate and the cytokine/chemokine network within the tumor was evaluated by flow cytometry, multicolor immunohistochemistry (IHC), gene expression profiling by Nanostring Technologies, and protein analysis by electrochemiluminescence and ELISA assays.

RESULTS: hetIL-15 treatment resulted in delayed primary tumor growth. Increased NK and CD8

CONCLUSIONS: Our results show that hetIL-15 administration enhances T cell entry into tumors, increasing the success rate of …

Effect Of Pembrolizumab Plus Neoadjuvant Chemotherapy On Pathologic Complete Response In Women With Early-Stage Breast Cancer: An Analysis Of The Ongoing Phase 2 Adaptively Randomized I-Spy2 Trial., Rita Nanda, Minetta C Liu, Christina Yau, Rebecca Shatsky, Lajos Pusztai, Anne Wallace, A Jo Chien, Andres Forero-Torres, Erin D Ellis, Heather Han, Amy Clark, Kathy Albain, Judy C Boughey, Nora T Jaskowiak, Anthony Elias, Claudine Isaacs, Kathleen Kemmer, Teresa Helsten, Melanie Majure, Erica Stringer-Reasor, Catherine Parker, Marie C Lee, Tufia Haddad, Ronald N Cohen, Smita Asare, Amy Wilson, Gillian L Hirst, Ruby Singhrao, Katherine Steeg, Adam Asare, Jeffrey B Matthews, Scott Berry, Ashish Sanil, Richard Schwab, W Fraser Symmans, Laura Van 'T Veer, Douglas Yee, Angela Demichele, Nola M Hylton, Michelle Melisko, Jane Perlmutter, Hope S Rugo, Donald A Berry, Laura J Esserman

Articles, Abstracts, and Reports

Importance: Approximately 25% of patients with early-stage breast cancer who receive (neo)adjuvant chemotherapy experience a recurrence within 5 years. Improvements in therapy are greatly needed.

Objective: To determine if pembrolizumab plus neoadjuvant chemotherapy (NACT) in early-stage breast cancer is likely to be successful in a 300-patient, confirmatory randomized phase 3 neoadjuvant clinical trial.

Design, Setting, and Participants: The I-SPY2 study is an ongoing open-label, multicenter, adaptively randomized phase 2 platform trial for high-risk, stage II/III breast cancer, evaluating multiple investigational arms in parallel. Standard NACT serves as the common control arm; investigational agent(s) are added to this backbone. Patients with …

Calcitonin Prescribing Criteria For The Management Of Hypercalcemia In A Community Hospital, Jessica Hernandez, Radhan Gopalani, Heidi Clarke, Joyce Lee, Alyssa Donadio

All Publications

Purpose/Background: Hypercalcemia is a clinical condition in which serum calcium levels exceed the upper limit of normal (>10.5 mg/dL). The most common causes of hypercalcemia are primary hyperparathyroidism and malignancy, however, it can also be caused by vitamin D intoxication, endocrine disorders, and immobilization due to an increase in bone resorption. First-line treatment of hypercalcemia includes hydration with intravenous (IV) normal saline and IV bisphosphonates. Calcitonin (Miacalcin®) is a synthetic hormone with a rapid onset of action and used intramuscularly (IM) or subcutaneously (SQ) as a second-line treatment in the management of hypercalcemia, specifically in severe and in symptomatic …

Whole Word Vs Phoneme Error Scoring For Audiological Word Recognition Testing, Jennifer C. Arnoult

Honors Theses

The purpose of this study was to investigate a possible alternative method of scoring for word recognition testing. The current whole word scoring method is inefficient and often inconsistent with a client’s pure tone average scores, and previous research has suggested that phoneme error scoring may be a more effective and accurate scoring method. This project analyzed the audiogram and word recognition test scores of seventeen adult clients. The test used was the standard twenty-five-word list NU-6 test. The researchers analyzed the results from whole word scoring and phoneme error scoring of the same tests and compared the results to …

Associations Of Sickness Absence For Pain In The Low Back, Neck And Shoulders With Wider Propensity To Pain, David Coggon, Georgia Ntani, Karen Walker-Bone, Vanda E. Felli, Raul Harari, Lope H. Barrero, Sarah A. Felknor, Marianela Rojas, Anna Cattrell, Muhammad Masood Kadir

Community Health Sciences

Objectives: To explore the association of sickness absence ascribed to pain at specific anatomical sites with wider propensity to musculoskeletal pain.
Methods: As part of the CUPID (Cultural and Psychosocial Influences on Disability) study, potential risk factors for sickness absence from musculoskeletal pain were determined for 11 922 participants from 45 occupational groups in 18 countries. After approximately 14 months, 9119 (78%) provided follow-up information about sickness in the past month because of musculoskeletal pain, including 8610 who were still in the same job. Associations with absence for pain at specific anatomical sites were assessed by logistic regression and summarised …

Exercise As A Mitigator Of Poor Mental Health Among Lesbian, Gay, And Bisexual Adults, Jennifer R. Pharr, Jason D. Flatt, Lung-Chang Chien, Axenya Kachen, Babayemi O. Olakunde

Environmental & Global Health Faculty Research

Introduction: There is a positive association between exercise and improved mental health in the general population. Although there is a greater burden of psychological distress among lesbian, gay, and bisexual (LGB) people, little is known about the association between exercise and mental health in this population. The authors explored the association between exercise and poor mental health reported by LGB adults in the United States. Methods: Our analyses used data from the 2017 Behavioral Risk Factor Surveillance System survey. Multiple regression analyses were used to determine the association between exercising and mental health days adjusting for sociodemographic characteristics. Results: Data …

Effects Of Concord Grape Juice Alone Or With Meals On Glycemia, Appetite And Cognitive Function In Healthy Adults, Aidan M. Hannon

Nutrition Science Honors Theses

Literature suggests that dietary polyphenols and intensely flavored foods/beverages can have a positive effect on glucose homeostasis. The purpose of this study was to determine if the high phenolic content and strong flavor intensity of Concord Grape Juice (CGJ) could hold beneficial effects on appetite, glycemia, and cognitive function.