Medicine and Health Sciences Commons^™

Steroid-Induced Hyperglycemia In Patients With Malignancies: Healthcare Team Adaptation To A Paradigm Shift, Miriam Ingrid Silva

Student Theses, Dissertations and Capstones

Background: Caring for patients with malignancies and presenting hyperglycemia has been an ongoing problem that needed to be addressed. The Endocrinologist Society and the Joint British Diabetes Societies for Inpatient Care suggested a change in the process by which patients in this population are managed. Purpose: The purpose of this project was to implement evidence-based practice guidelines for managing steroid-induced hyperglycemia focusing on the interdisciplinary team and adaptation of nurses who care for patients with malignancies. Theoretical Framework: The theoretical framework selected for this project was Roy’s Adaptation Model. Methods: This project used a mixed method approach, with a triangulation …

Health Care Providers' Knowledge Of Childhood Obesity Within The Hispanic Community, Daysi Fardales

Student Theses, Dissertations and Capstones

Background: Recent studies indicate a rise in the prevalence of obesity in children of various age groups. Obesity was officially recognized as a disease by the American Medical Association (AMA) in June 2013. It has been acknowledged as a progressive epidemic public health crisis in the United States for the past 20 years. This is a health care concern that needs examination and the development of new and more effective prevention and treatment modalities for obesity in children. Environmental, hereditary, behavioral, and socioeconomic factors play a significant role in the prevalence of obesity (Rooney, Mathiason, & Schauberger, 2011). Childhood obesity …

Addressing Obstetric Health Care Providers' Nutritional Insight In The Low Socioeconomic Population, Nicole Theresa Marshall

Student Theses, Dissertations and Capstones

Background: During a woman's pregnant state, a diet that is adequate in nutrition is critical to the developing fetus, especially in the lower socioeconomic status population. The healthcare provider is charged with the acute fundamental awareness of this additional factor that can grossly impact pregnancy. Nutritional advice from the health care provider is one of many key points that contribute to the successful outcome of the pregnancy. Purpose: The purpose of this quality improvement project was to develop a standardized, evidence-based practice (EBP) protocol for the management of maternal nutrition, gestational weight gain, and physical activity for provider use at …

Characteristics Associated With Successful Dental Treatment In Children With Autism Spectrum Disorder, Noah Turk

Student Theses, Dissertations and Capstones

Background. ASD is a neurodevelopmental disability, responsible for social, communicative and behavioral deficits. The prevalence of children diagnosed with ASD in the United States has more than doubled in the past two decades, from 1 in 150 to 1 in 68. Children diagnosed with ASD have a very high occurrence of certain comorbidities, such as developmental delay, intellectual disability and speech delay. Unmet dental needs remain high among children with special health care needs (SHCN), with 78% reporting the need for dental care within the last 12 months. Recent studies have focused on barriers to care for these patients; the …

Bmp2 Enhances Osteogenesis Of Gingival Stem Cells In Peptide Hydrogel, Annapurna Bondalapati

Student Theses, Dissertations and Capstones

Purpose: The aim of the study was to investigate effect of the growth factor, Bone Morphogenetic Protein 2 (BMP2), on the differentiation of Human gingiva derived stem cells (HGMSCs) in a self-assembled three-dimensional (3D) peptide hydrogel. The study has two parts; part 1 comprised of optimizing the dose of BMP2 and Part II was investigating the effective delivery method of BMP2 in enhancing the osteogenic differentiation of HGMSCs Methods: Human gingiva derived mesenchymal stem cells (HGMSCs) cultured in the peptide hydrogel (3-D cultures) were treated with 50, 100 and 200 ng/ml BMP2. The cells in the osteogenic differentiation of HGMSCs …

Indirect Bonding Of Orthodontic Brackets: A Comparison Of Positional Accuracy Between Software Vs. Stone Model Driven Techniques, Francesca Scilla Smith

Student Theses, Dissertations and Capstones

Background: Many orthodontic clinicians consider indirect bonding of orthodontic brackets as a method of achieving greater accuracy and effectiveness in orthodontic treatment. Currently, few features of our world have escaped the influence of technology. The indirect system of orthodontic bonding offers an example of technology’s power through a computer-driven system that enables customized bracket placement that optimizes esthetics, accuracy, precision and efficiency. The purpose of this study was to compare the positional accuracy and reliability between traditional and computer-generated indirect bonding techniques. Methods: A total of 210 brackets (STEP metal brackets with slot size .022x.028) were placed using a four …

Risk Factors For Low Back Pain In Recreational Distance Runners, Jonathan Gallas

Department of Physical Therapy Student Theses, Dissertations and Capstones

Risk Factors for Low Back Pain in Recreational Distance Runners By Jonathan E. Gallas Purpose. The purpose of this study was to examine differences between runners with and without low back pain and a control group of non-runners in demographic, physical/running, and LBP variables. Subjects. This study included 102 subjects in three groups. Subjects, 18 to 55 years old, were from a running store, sports club, and physical therapy clinics in Rockford, IL. Methods. A pilot study of ten runners with LBP was conducted prior to data collection to assess testers’ reliability. One hundred and twelve runners, with or without …

Immediate Effects Of A Seated Versus Supine Upper Thoracic Spine Thrust Manipulation Compared To Sham Manipulation In Individuals With Subacromial Pain Syndrome – A Randomized Clinical Trial, Jason Keith Grimes

Department of Physical Therapy Student Theses, Dissertations and Capstones

Background: Individuals with Subacromial Pain Syndrome (SPS) often present with a variety of contributing factors. It is possible that a subgroup exists within SPS that has primary impairments of scapular mobility and/or muscle strength. In an attempt to better identify scapular contributions in SPS, the Scapular Assistance Test (SAT) and Scapula Reposition Test (SRT) have been described. Additionally, thoracic spine thrust manipulation has been shown to be effective for shoulder pain. Problem Statement: It is currently unknown whether or not there are impairments in scapulothoracic muscle force generation or scapular mobility in individuals with SPS who have positive results on …

Iliotibial Band Length And Patellofemoral Pain Syndrome: Relationship Between Two Measurement Techniques, Duane Michael Scotti

Department of Physical Therapy Student Theses, Dissertations and Capstones

Purpose: To determine the relationship between iliotibial band (ITB) length and the presence of patellofemoral pain syndrome (PFPS), compare the difference in ITB length between the painful knee and the non-painful knee in subjects with unilateral PFPS, determine the test-retest reliability, standard error of measurement, and minimal detectable change (MDC) of the Ober test and modified Thomas test, and explore the relationship between the Ober test and the modified Thomas test in measuring ITB length. Subjects: Forty-eight subjects were recruited (PFPS group n=24, control group n=24) from three different outpatient physical therapy clinics. Methods: The Ober test and modified Thomas …

Cost Of Physical Therapists Serving As A Musculoskeletal Providers Compared To Family Practice Providers In A Military Treatment Facility, Troy Edward Mcgill

Department of Physical Therapy Student Theses, Dissertations and Capstones

Background. Physical therapists (PTs) in the U.S. military practice direct access and can order limited prescription medications, imaging studies. Military PTs function as autonomous primary care managers (PCMs) for patients with musculoskeletal (MSK) disorders. Objective. The study compared cost of PT management of patients with MSK disorders to management by traditional PCMs; medical doctors (MDs), doctors of osteopathic medicine (DOs), advanced registered nurse practitioners (ARNPs), and physician assistants (PAs). Methods. The researcher used a retrospective study of electronic medical records, using an exploratory, non-experimental, cross-sectional, and quantitative design method. Results. At an Air Force military medical clinic during an 18-month …

Educational Program Attributes And Faculty Teaching Behaviors As Predictors Of National Physical Therapy Examination Success, Natonya Frazier-Early

Department of Physical Therapy Student Theses, Dissertations and Capstones

Purpose: To determine the differences between PT program NPTE 3-year ultimate pass rates (3YUPR) based on program length and faculty scholarship. To explore relationships between 3YUPR and quality faculty behaviors. Subjects: A total of 112 CAPTE accredited PT educational programs in the United States and Puerto Rico during 2013. Method: A quantitative design method was used to retrospectively test differences between program and faculty traits and student NPTE 3YUPR using data from the Commission on Accreditation in Physical Therapy Education (CAPTE), PT Annual Accreditation Reports (AAR) and Federation of State Boards of Physical Therapy (FSBPT) score reports. A self-generated faculty …

Dry Needling Of Myofascial Trigger Points: Quantification Of The Biomechanical Response Using A Myotonometer., Joseph P. Kelly

Department of Physical Therapy Student Theses, Dissertations and Capstones

Background: Biomechanical stiffness has been linked to risk of injury and found to be a measureable characteristic in musculoskeletal disorders. Specific identification of stiffness may clarify who is most likely to benefit from the trigger point dry needling (TDN). The purpose of this study is to investigate the reliability and concurrent validity of the MyotonPRO® to the criterion of shear wave ultrasound elastography for the measurement of biomechanical stiffness in the infraspinatus, erector spinae, and gastrocnemius of healthy subjects over increasing muscle contraction. Second purpose is to investigate the biomechanical effects of TDN to latent myofascial trigger points (MTrPs) in …

Gait Analysis Following Total Knee Arthroplasty During Inpatient Rehabilitation: Can Findings Predict Los, Ambulation Device, And Discharge Disposition?, Janet Anne Herbold

Department of Physical Therapy Student Theses, Dissertations and Capstones

Background: Total knee arthroplasty (TKA) is the treatment of choice for end-stage knee osteoarthritis. Growth in the number of procedures performed annually in the United States is expected to increase steadily. Post-operative rehabilitation settings vary and include both institutional and community based physical therapy (PT) services. Despite access to PT, deficits in gait often persist for months and even years after surgery. Slow gait speed, asymmetrical walking patterns, and prolonged time in double-limb support following the TKA often lead to the need for an assistive device for walking and prolong the rehabilitation phase. Purpose: The purpose of this study is …

The Er Retention Protein Rer1 Promotes Alpha-Synuclein Degradation Via The Proteasome, Hyo-Jin Park, Daniel Ryu, Mayur Parmar, Benoit I. Giasson, Nikolaus R. Mcfarland

HPD Articles

Abnormal accumulation of α-synuclein (αSyn) has been linked to endoplasmic-reticulum (ER) stress, defective intracellular protein/vesicle trafficking, and cytotoxicity. Targeting factors involved in ER-related protein processing and trafficking may, therefore, be a key to modulating αSyn levels and associated toxicity. Recently retention in endoplasmic reticulum 1 (RER1) has been identified as an important ER retrieval/retention factor for Alzheimer's disease proteins and negatively regulates amyloid-β peptide levels. Here, we hypothesized that RER1 might also play an important role in retention/retrieval of αSyn and mediate levels. We expressed RER1 and a C-terminal mutant RER1Δ25, which lacks the ER retention/retrieval function, in HEK293 and …

Conversation Analysis Of Michael White’S Decentered And Influential Position, Dragana Ilic

Department of Family Therapy Dissertations and Applied Clinical Projects

The relationship between the therapist and the client is an important consideration for most models of therapy, with all models of therapy emphasizing the importance of establishing a positive therapeutic relationship. Quantitative and qualitative studies have shown that the relationship between the therapist and the client is a predictor of positive outcomes. However, different models define the preferred therapeutic relationship differently. This study was a qualitative exploration of a decentered and influential position of the therapist in narrative therapy. A video of a one-session narrative therapy case conducted by Michael White was analyzed using conversation analysis to answer the following …

Distribution Of Camptotheca Decaisne: Endangered Status, Shiyou Li, Yanli Zhang, Katie Northrup, Dehui Zhang

NCPC Publications and Patents

Camptotheca Decaisne is endemic to southern China. Since 1934, C. acuminata has been widely introduced to many gardens and arboreta in North America, Asia, and Europe as living collections. Our national surveys in China between 1995 and 1998 indicated that the genus. Camptotheca spp. are severely endangered in native range. Our field surveys failed to locate any wild populations of C. acuminata although it is often cultivated as landscape trees in southern China. We could not identify any living trees of C. acuminata var. tenuifolia and var. rotundifolia. We estimated that there are approximately 500 mature trees of C. lowreyana …

Phenolics From The Fruits Of Maclura Pomifera, Zushang Su, Ping Wang, Wei Yuan, Greg Grant, Shiyou Li

NCPC Publications and Patents

Two new compounds, maclurin A (1) and maclurin B (2), and six known ones, ononin (3), pterofuran (4), osajin (5), pomiferin (6), 3,4-dihydroxybenzoic acid (7), and 2,3,4-trihydroxybenzoic acid (8) were isolated from the fruit of Maclura pomifera. Compounds 3 and 4 were isolated from the genus for the first time. Structure elucidation was achieved by spectroscopic measurements and by comparison with literature data. Compounds 2-4 exhibited activities against the cancer cell lines A549 and Panc-28 with GI₅₀ values from 18.1 to 32.2, and 20.6 to 43.5 μM, respectively. Compounds 2 and 4 also showed cytotoxicity against HCT 116 …

Ready To Learn: The Impact Of The Morning Blast Physical Activity Intervention On Elementary School Students, Tingting Xu, Erik Jon Byker, Monica Rae Gonzales

Faculty Publications

Objective: The purpose of this study was to investigate the effects of a physical activity intervention programme, named “Morning Blast”, on elementary school students’ math learning and daily physical activity. The Morning Blast intervention programme was a 16-week cardiovascular endurance emphasized physical activity program that students voluntarily participated in before the school day. Participants that volunteered, did so for the duration of the program. Methods: This mixed-methods study included seven educators and 83 students (n=90). The students were all children who were enrolled in Grades 3, 4, and 5 in a semi-rural elementary school in the United States. …

Variations Of Emotion Dysregulation In Borderline Personality Disorder: A Latent Profile Analysis Approach With Adult Psychiatric Inpatients, Katrina A. Rufino, Thomas E. Ellis, Joshua Clapp, Catherine Pearte, J. Christopher Fowler

Faculty Publications

Background

The purpose of the present study was to identify variations in emotional dysregulation patterns among adults diagnosed with borderline personality disorder (BPD), with an eye toward implications for treatment.

Methods

Latent profile analysis (LPA) was utilized to classify 156 inpatients with BPD, based on patterns of Difficulties in Emotion Regulation Scale (DERS; Gratz and Roemer, J Psychopathol Behav Assess 26: 41-54, 2004) subscale scores.

Results

Results revealed that a three class solution best fit the sample (Low Impairment, Global Dysregulation, and Emotionally Aware). Further analysis of the classes at admission revealed that the Global Dysregulation group reported significantly higher …

Life Of A Child With Hypotonia, Shannon Valedta

School of Human Sciences Research Showcase

The disorder is found in infants, and not many people heard of this disability. People need to be informed about Hypotonia so that it will benefit research to develop a cause and cure to Hypotonia. Also, in our field we are able to educate parents and therapists about what is Hypotonia, and develop techniques for the child to be able to develop properly.

What is Benign Congenital Hypotonia

Benign Congenital Hypotonia, also known as "Floppy Baby Syndrome", is the medical term for low muscle tone.

End-Of-Life Training In Us Internal Medicine Residency Programs: A National Study, Derek Cegelka, Timothy R. Jordan, Jiunn-Jye Sheu, Joseph A. Dake, Ragheb Assaly

Faculty Publications

Background: End-of-life care is a required and important component of medical training for internal medicine residents; many of whom will go on to provide care for adults at the end-of-life stage. Although a body of past research suggests that physician training in end-of-life care needs significant improvement, a comprehensive national study of end-of-life education within US internal medicine residency programs has never been published.

Objective: To determine the status of end-of-life education in internal medicine residency programs in the United States.

Method: The study was a cross-sectional, observational study of all internal medicine Residency Program Directors in the US as …

Biophysical Approaches Facilitate Computational Drug Discovery For Atp-Binding Cassette Proteins, Steven V. Molinski, Zoltan Bozoky, Surtaj H. Iram, Saumel Ahmadi

Chemistry and Biochemistry Faculty Publications

Although membrane proteins represent most therapeutically relevant drug targets, the availability of atomic resolution structures for this class of proteins has been limited. Structural characterization has been hampered by the biophysical nature of these polytopic transporters, receptors, and channels, and recent innovations to in vitro techniques aim to mitigate these challenges. One such class of membrane proteins, the ATP-binding cassette (ABC) superfamily, are broadly expressed throughout the human body, required for normal physiology and disease-causing when mutated, yet lacks sufficient structural representation in the Protein Data Bank. However, recent improvements to biophysical techniques (e.g., cryo-electron microscopy) have allowed for previously …

State-Level Immunization Information Systems: Potential For Childhood Immunization Data Linkages., Jill E. Fuller, Emmanuel B. Walter Jr., Nancy Dole, Richard O'Hara, Amy H. Herring, Maureen S. Durkin, Bonny Specker, Betty Wey

Ethel Austin Martin Program Publications

Objectives Sources of immunization data include state registries or immunization information systems (IIS), medical records, and surveys. Little is known about the quality of these data sources or the feasibility of using IIS data for research. We assessed the feasibility of collecting immunization information for a national children's health study by accessing existing IIS data and comparing the completeness of these data against medical record abstractions (MRA) and parent report. Staff time needed to obtain IIS and MRA data was assessed. Methods We administered a questionnaire to state-level IIS representatives to ascertain availability and completeness of their data for research …

Studying The Optimal Scheduling For Controlling Prostate Cancer Under Intermittent Androgen Suppression, Sunil K. Dhar, Hans R. Chaudhry, Bruce G. Bukiet, Zhiming Ji, Nan Gao, Thomas W. Findley

Harvard University Biostatistics Working Paper Series

This retrospective study shows that the majority of patients’ correlations between PSA and Testosterone during the on-treatment period is at least 0.90. Model-based duration calculations to control PSA levels during off-treatment are provided. There are two pairs of models. In one pair, the Generalized Linear Model and Mixed Model are both used to analyze the variability of PSA at the individual patient level by using the variable “Patient ID” as a repeated measure. In the second pair, Patient ID is not used as a repeated measure but additional baseline variables are included to analyze the variability of PSA.

Sequence Homology Between Hla-Bound Cytomegalovirus And Human Peptides: A Potential Trigger For Alloreactivity, Charles E. Hall, Vishal N. Koparde, Maximilian Jameson-Lee, Abdelrhman G. Elnasseh, Allison F. Scalora, David J. Kobulnicky, Myrna G. Serrano, Catherine H. Roberts, Gregory A. Buck, Michael C. Neale, Daniel E. Nixon, Amir A. Toor

Massey Cancer Center Publications

Human cytomegalovirus (hCMV) reactivation may often coincide with the development of graft-versus-host-disease (GVHD) in stem cell transplantation (SCT). Seventy seven SCT donor-recipient pairs (DRP) (HLA matched unrelated donor (MUD), n = 50; matched related donor (MRD), n = 27) underwent whole exome sequencing to identify single nucleotide polymorphisms (SNPs) generating alloreactive peptide libraries for each DRP (9-mer peptide-HLA complexes); Human CMV CROSS (Cross-Reactive Open Source Sequence) database was compiled from NCBI; HLA class I binding affinity for each DRPs HLA was calculated by NetMHCpan 2.8 and hCMV- derived 9-mers algorithmically compared to the alloreactive peptide-HLA complex libraries. Short consecutive (≥6) …

The Effects Of Fetal Alcohol Exposure On Gene Expression And Associated Behavioral Markers In Sprague Dawley Rats, Sarah Willey

Biology Honors Papers

Alcohol is a dangerous recreational substance because of its availability and the economic, social, and biological problems that it can cause. Fetal alcohol exposure, although preventable, is particularly harmful to a developing embryo. This exposure often causes fetal alcohol spectrum disorder (FASD), the symptoms of which include learning disabilities and psychological hardships with comorbidities such as anxiety, depression, and attention deficit disorder. One of the main teratogenic effects of alcohol is the effect on epigenetic modifications and altered gene expression during development. These modifications involve changes in the methylation and condensation of DNA that then alters the expression of specific …

Glecaprevir And Pibrentasvir For 12 Weeks For Hepatitis C Virus Genotype 1 Infection And Prior Direct-Acting Antiviral Treatment, F. Poordad, F. Felizarta, A. Asatryan, M. S. Sulkowski, R. W. Reindollar, C. S. Landis, S. C. Gordon, S. L. Flamm, D. E. Bernstein, F. J. Mensa, +6 Additional Authors

Journal Articles

No abstract provided.

Screening For Depression In Cancer Patients Receiving Radiotherapy: Feasibility And Identification Of Effective Tools In The Nrg Oncology Rtog 0841 Trial, L. I. Wagner, S. L. Pugh, W. Small, J. Kirshner, K. Sidhu, M. J. Bury, A. S. Denittis, T. E. Alpert, B. F. Bloom, D. W. Bruner, +6 Additional Authors

Journal Articles

No abstract provided.

Anesthesia Duration As An Independent Risk Factor For Early Postoperative Complications In Adults Undergoing Elective Acdf., K. Phan, J. S. Kim, J. H. Kim, S. Somani, J. Di'capua, J. E. Dowdell, S. K. Cho

Journal Articles

Study Design: Retrospective study.

Objective: To determine the presence of any potential associations between anesthesia time with postoperative outcome and complications following elective anterior cervical discectomy and fusion (ACDF).

Methods: Patients who underwent elective ACDF were identified in the American College of Surgeons National Quality Improvement Program database. Patient demographics, medical comorbidities, and perioperative and postoperative complications up to 30 days were analyzed by univariate and multivariate analysis.

Results: A total of 3801 patients undergoing elective ACDF were identified. Patients were subdivided into quintiles of anesthesia time: Group 1, 48 to 129 minutes (n = 761, 20%); Group 2, 129 …

Gender Disparity In Clinical Trials: Research Professionals’ Perspective Regarding Their Own Female Patient's Barriers, V1, 2015, Anita Kurt Phd, Rn, Lauren Semler Ms, Matthew Meyers Bs, Samantha Myles Rn, Bernadette Glenn-Porter Bs, Tyler Adams Bs, Micaela Wilson Ba, Jeanne L. Jacoby Md, John C. Smulian Md, Mph

Department of Emergency Medicine

No abstract provided.