Medicine and Health Sciences Commons^™

Reassessing Visual Assessment Techniques In Lead Project For Scott County, Hannah Lindaman

2016-2017: Scott County, Iowa and the Scott County Health Department

The Upper Mississippi Center has been working closely with Scott County Health Department on a two-year project addressing the stunningly high rates of lead poisoning in parts of Scott County, Iowa. This formal report correlates visual characteristics with the risk-category of lead poisoning in specific parcels in Scott County. Data was collected from the pilot survey in the winter of 2016 and used to run tests using SPSS to find relationships between the visual characteristics that were assessed and the risk-category of the parcel. This report aims to address the fact that the standard for residential visual assessment has a …

Black Hawk County’S Approach To Lead Poisoning, Ashley Comeau, Taylor Campbell, Nathan Ambrose, Travis Pulse

2016-2017: Scott County, Iowa and the Scott County Health Department

Scott County, IA is facing a community lead poisoning problem, much like other counties in the state. One of these are Black Hawk County, northwest of Scott. Black Hawk County approached the lead poisoning problem by partnering with organizations including the University of Northern Iowa, the Iowa Poison Control Center, and a multitude of medical groups. Funding, procedures for action, and education were also factors in assessing the lead problem. Black Hawk County’s number of lead poisonings decreased after approaching the problem, while Scott County’s problem worsened. By using similar methods, we hope that Scott County's lead problem will also …

Lead Poisoning In Linn County & Cedar Rapids, Ia, Sydney Fedor, Lexys Magadan, Shannon Okland, Morghan Smith, Anna Willems

2016-2017: Scott County, Iowa and the Scott County Health Department

No abstract provided.

Exploring Alternative Funding Methods For The Lead Remediation Program In Scott County, Iowa, Brittany A. Poynor, Layne Porembski, Arielle Bloemer, Brandon Schattner, Sarah Hanson

2016-2017: Scott County, Iowa and the Scott County Health Department

For this project, five students worked to put together five alternative funding solutions for the Scott County Health Department's lead remediation program. With limited government grants available, the health department is now considering local funding in order to address the issue of lead poisoning in Davenport, Iowa. These reports, along with other SWLI research, provide valuable information and are the foundation of the up-and-coming remediation program for the county.

The Lead Poisoning Problem In Polk County And Des Moines, Ia, Ami Leichsenring, Naomi Castro, Vanessa Dominguez, Samantha G. De Forest-Davis, Keila Saucedo

2016-2017: Scott County, Iowa and the Scott County Health Department

No abstract provided.

Lead Poisoning: A Guide For Homeowners, Brenna Whisler, Tracy Ngo

2016-2017: Scott County, Iowa and the Scott County Health Department

No abstract provided.

How Do Communities Proactively Address Lead Remediation? : Community Case Studies From Iowa, Dr. Angie L. Carter, Emma Nordmeyer

2016-2017: Scott County, Iowa and the Scott County Health Department

In 2016, Scott County Health Department officials reached out to the Sustainable Working Landscapes Initiative (SWLI) program at Augustana College to begin a partnership addressing lead poisoning in our community. Teams of students in the Fall 2016 Contemporary Social Issues class conducted sociological case studies of communities in Iowa that are proactively addressing lead remediation through combinations of United States Department of Housing and Urban Development (HUD) and private funding. Groups of students conducted case studies in Dubuque, Linn, Polk, Marshall, and Black Hawk counties in Iowa. Students researched the demographics of these areas as well as successes, lessons learned, …

Exploring Alternative Funding Methods For The Lead Remediation Program In Scott County, Iowa, Dr. John Delaney, Brittany A. Poynor

2016-2017: Scott County, Iowa and the Scott County Health Department

Lead poisoning is an environmental as well as social problem. Areas with more older housing and higher rates of poverty are also the areas with the most lead poisoned children. Though the United States banned the use of lead paint in in 1978 and lead poisoning is preventable, lead poisoning remains a public health problem. Homes built before 1978 may pose risk of lead paint exposure, but of special concern to Scott County are the number of homes built before 1950.

Scott County, Iowa is home to some of the oldest housing units in the U.S. Iowa ranks fifth among …

Fighting Lead Poisoning With Food, Brenna Whisler, Tracy Ngo

2016-2017: Scott County, Iowa and the Scott County Health Department

No abstract provided.

Critically Appraised Paper For “The Effects Of A Home-Based Virtual Reality Rehabilitation Program On Balance Among Individuals With Parkinson’S Disease”, Amanda Lee, Sophie E. Miller, Holly Snyder, Phoebe Taasan, Kitsum Li

Occupational Therapy | Critically Appraised Papers Series

This study evaluated the effectiveness of a 12-week home-based exercise program using the Nintendo Wii system in its capacity to improve balance and balance confidence and maintain exercise compliance. Balance and balance confidence were measured with the Center of Pressure Length (COPL) and Activities-Specific Balance Confidence Scale (ABC), which were administered before the start of the intervention, 6 weeks into the intervention, and within 1 week postintervention. Although changes in balance and balance confidence scores were found to be nonsignificant, a pattern emerged in which scores for both measures rose between preand postintervention assessments, then fell to nearly baseline levels …

Critcally Appraised Paper For: “Is Modified Constraint-Induced Movement Therapy More Effective Than Bimanual Training In Improving Arm Motor Function In The Subacute Phase Post Stroke? A Randomized Controlled Trial.”, Jason Ichimaru, Jennifer Sik, Kelly Schmidt, Kitsum Li

Occupational Therapy | Critically Appraised Papers Series

Patients poststroke compose one of the largest demographics treated by occupational therapists in the physical disability setting. Approximately two-thirds of individuals who have had a stroke present with arm function impairment (Kwakkel & Kollen, 2007). Therefore, effective arm rehabilitation in occupational therapy settings is critical to help patients regain functional independence and quality of life. Modified constraint-induced movement (MCIM) therapy has been reported as the superior method of arm rehabilitation for individuals in the subacute phase poststroke, although recent research has also supported bimanual training. This 4-week, randomized controlled, quantitative study compared the effect of MCIM therapy and bimanual task-related …

Attenuation Of Postoperative Adhesions Using A Modeled Manual Therapy (Data Files), Geoffrey M. Bove, Susan L. Chapelle, Katherine E. Hanlon, Michael P. Diamond, David J. Mokler

Biomedical Sciences Faculty Publications

These files include data and figures utilized to research and communicate the following:

Postoperative adhesions are pathological attachments that develop between abdominopelvic structures following surgery. Considered unavoidable and ubiquitous, postoperative adhesions lead to bowel obstructions, infertility, pain, and reoperations, and represent a substantial health care challenge. Despite over a century of research, no preventive treatment exists. Based on the hypothesis that postoperative adhesions develop from a lack of movement of the abdominopelvic organs, we proposed a relatively simple treatment approach using a modified manual therapy technique that mobilizes abdominopelvic structures in the immediate postoperative period while they are otherwise rendered …

Can Real-Time Visual Feedback During Gait Retraining Reduce Metabolic Demand For Individuals With Transtibial Amputation?, Elizabeth R. Esposito, Harmony S. Choi, Benjamin J. Darter, Jason M. Wilken

Physical Therapy Publications

The metabolic demand of walking generally increases following lower extremity amputation. This study used real-time visual feedback to modify biomechanical factors linked to an elevated metabolic demand of walking in individuals with transtibial amputation. Eight persons with unilateral, traumatic transtibial amputation and 8 uninjured controls participated. Two separate bouts of real-time visual feedback were provided during a single session of gait retraining to reduce 1) center of mass sway and 2) thigh muscle activation magnitudes and duration. Baseline and post-intervention data were collected. Metabolic rate, heart rate, frontal plane center of mass sway, quadriceps and hamstrings muscle activity, and co-contraction …

Dynamical System Modeling To Simulate Donor T Cell Response To Whole Exome Sequencing-Derived Recipient Peptides: Understanding Randomness In Alloreactivity Incidence Following Stem Cell Transplantation, Vishal Koparde, Badar Abdul Razzaq, Tara Suntum, Roy Sabo, Allison Scalora, Myrna Serrano, Max Jameson-Lee, Charles Hall, David Kobulnicky, Nihar Sheth, Juliana Feltz, Daniel Contaifer, Dayanjan Wijesinghe, Jason Reed, Catherine Roberts, Rehan Qayyum, Gregory Buck, Michael Neale, Amir Toor

Massey Comprehensive Cancer Center Data

Quantitative relationship between the magnitude of variation in minor histocompatibility antigens (mHA) and graft versus host disease (GVHD) pathophysiology in stem cell transplant (SCT) donor-recipient pairs (DRP) is not established. In order to elucidate this relationship, whole exome sequencing (WES) was performed on 27 HLA matched related (MRD), & 50 unrelated donors (URD), to identify nonsynonymous single nucleotide polymorphisms (SNPs). An average 2,463 SNPs were identified in MRD, and 4,287 in URD DRP (p

Genetic And Environmental Structure Of Dsm-Iv Criteria For Antisocial Personality Disorder: A Twin Study, Tom Rosenström, Eivind Ystrom, Fartein Ask Torvik, Nikolai Olavi Czajkowski, Nathan A. Gillespie, Steven H. Aggen, Robert F. Krueger, Kenneth S. Kendler, Ted Reichborn-Kjennerud

Psychiatry Publications

Results from previous studies on DSM-IV and DSM-5 Antisocial Personality Disorder (ASPD) have suggested that the construct is etiologically multidimensional. To our knowledge, however, the structure of genetic and environmental influences in ASPD has not been examined using an appropriate range of biometric models and diagnostic interviews. The 7 ASPD criteria (section A) were assessed in a population-based sample of 2794 Norwegian twins by a structured interview for DSM-IV personality disorders. Exploratory analyses were conducted at the phenotypic level. Multivariate biometric models, including both independent and common pathways, were compared. A single phenotypic factor was found, and the best-fitting biometric …

Yap Functions Via Tead Mediated Transcriptional Activation In Hepatoblastoma Pathogenesis, Junyan Tao 8598903, Pin Liu, Jie Zhang, Sucha Singh, Xin Chen, Na Zhan, Satdarshan (Paul) Singh Monga

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

The Role Of Menin-Mll Interaction In The Dissociation Between Cholestatic Liver Diseases And Cholangiocarcinoma, Laurent Ehrlich 2085637, Chad Hall Dr., Tori Sheppard, Julie Venter, April O'Brien, Terry C. Lairmore Dr., Gianfranco Alpini Dr., Shannon Glaser Dr.

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Notch2 Controls Hepatocyte-Derived Cholangiocarcinoma Formation In Mice, Jingxiao Wang, Mingjie Dong, Xinhua Song, Kaiwen Hu, Xin Chen

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Survival Model Of Intrahepatic Cholangiocarcinoma; Sex As A Biological Variable, Mary A. Phillippi, Justin L. Mott, Cody J. Wehrkamp, Ying Xie, David Oupicky, Ashley M. Mohr, Bailey A. Stringham

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

A Comprehensive Tcga Based Analysis Of Disruptions In Tgf-Β Pathway Across 33 Human Cancers, Sobia Zaidi

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Hepatocellular Cancer Genome And Transcriptome Analysis Validates Clinically Significant Mutational Signatures With The Tgf-𝛃 Pathway, Shuyun Rao, Jian Chen, Kazufumi Ohshiro, Shoujun Gu, Sobia Zaidi, Wilma S. Jogunoori, Jon White, Nagarajan Pattabiraman, Raja Mazumder, Anelia Horvath, Ray-Chang Wu, Shulin Li, Chuxia Deng, Bibhuti Mishra, Rehan Akbanni, The Tcga Cancer Network, Lopa Mishra

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Alcoholic Liver Diseases, Stem Cell Disorder And Hepatocellular Carcinoma, Shoujun Gu, Shuyun Rao, Sobia Zaidi, Kazufumi Ohshiro, Jian Chen, Wilma Jogunoori, Jon White, Nagarajan Pattabiraman, Raja Mazumder, Anelia Horvath, Ray-Chang Wu, Sjhulin Li, Chu-Xia Deng, Rehan Akbani, Bibhuti Mishra, Lopa Mishra

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Transcriptional Reprograming That Persists After Clearance Of Oncogenic Hepatitis C Virus, Atsushi Ono, Francis J. Eng, Frank Juehling, Nourdine Hamdane, Naoto Fujiwara, Takaaki Higashi, Billie C. Bian, Hadassa Hirschfield, Vera Kim, Thomas F. Baumert, Andrea D. Branch, Yujin Hoshida

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

A New Hcc Model Induced By Co-Overexpression Fgf19 And Met In Mice, Junyan Tao 8598903, Morgan Preziosi, Sucha Singh, Xin Chen, Satdarshan (Paul) Singh Monga

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Convergence Of Wnt/Beta-Catenin And Mtor Signaling In Liver Physiology And Hepatocellular Carcinoma, Adeola O. Adebayo Michael, Junyan Tao, Satdarshan P. Monga

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Bile Acids Contribute To The Gender-Biased Incidence Of Hcc, Megan E. Patton, Sherwin H. Kelekar, Rhishikesh Thakare, Yazen Alnouti, Sayeepriyadarshini Anakk

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Autophagy Is Involved In Hdac6 Mediated Ciliary Loss, And Increases Malignancy In Cholangiocarcinoma Models, Estanislao Peixoto, Stephanie Holtorf, Kristen Thelen M. Thelen, Maria J. Lorenzo Pisarello, Nicholas F. Larusso, Sujeong Jin, Sergio A. Gradilone

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Identification Of Common Molecular Subtypes Of Asian Hepatocellular Carcinoma And Cholangiocarcinoma., Anuradha Budhu, Jittiporn Chaisaingmongkol, Hien Dang, So Mee Kwon, Siritida Rabibhadana, Benjarath Pupacdi, Marshonna Forgues, Yosawat Pomyen, Vajarabhongsa Bhudhisawasdi, Nirush Lertprasertsuke, Anon Chotirosniramit, Chawalit Pairojkul, Chirayu Auewarakul, Thaniya Sricharunrat, Kannika Phornphutku, Suleeporn Sangrajrang, Maggie Cam, Ping He, Stephen M. Hewitt, Xiaolin Wu, Snorri S. Thorgeirsson, Paul S. Meltzer, Christopher Loffredo, Robert H. Wiltrout, Curtis C. Harris, Chulabhorn Mahidol, Mathuros Ruchirawat, Xin W. Wang

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Cd28 Blockade Ex Vivo Induces Alloantigen-Specific Immune Tolerance But Preserves T-Cell Pathogen Reactivity., Barbara Dillinger, Sarah Ahmadi-Erber, Klara Soukup, Angela Halfmann, Silke Schrom, Bernard Vanhove, Peter Steinberger, Rene Geyeregger, Stephan Ladisch, Alexander Michael Dohnal

Pediatrics Faculty Publications

Donor T-cells contribute to reconstitution of protective immunity after allogeneic hematopoietic stem cell transplantation (HSCT) but must acquire specific tolerance against recipient alloantigens to avoid life-threatening graft-versus-host disease (GvHD). Systemic immunosuppressive drugs may abrogate severe GvHD, but this also impedes memory responses to invading pathogens. Here, we tested whether ex vivo blockade of CD28 co-stimulation can enable selective T-cell tolerization to alloantigens by facilitating CD80/86-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) signaling. Treatment of human allogeneic dendritic cell/T-cell co-cultures with a human CD28 blocking antibody fragment (α-huCD28) significantly abrogated subsequent allospecific immune responses, seen by decreased T-cell proliferation and of type 1 …

Altered Cerebellar Biochemical Profiles In Infants Born Prematurely, Marie Brossard-Racine, Jonathan Murnick, Marine Bouyssi-Kobar, Janie Coloumbe, Taeun Chang, Catherine Limperopoulos

Radiology Faculty Publications

This study aims to compare the cerebellar biochemical profiles in preterm (PT) infants evaluated at term equivalent age (TEA) and healthy full-term newborns using proton magnetic resonance spectroscopy (1H-MRS). We explore the associations between altered cerebellar metabolite profiles and brain injury topography, severity of injury, and prematurity-related clinical complications. We prospectively collected high quality 1H-MRS in 59 premature infants born ≤32 weeks and 61 healthy full term controls. 1H-MRS data were processed using LCModel software to calculate absolute metabolite concentration for N-acetyl-aspartate (NAA), choline (Cho) and creatine (Cr). PT infants had significantly lower cerebellar NAA (p < 0.025) and higher Cho (p < 0.001) at TEA when compared to healthy controls. Creatine was not different between the two groups. The presence of cerebellar injury was consistently associated with reduced concentrations for NAA, Cho, and Cr. Postnatal infection was negatively associated with NAA and Cr (p < 005), while cerebral cortical brain injury severity was inversely associated with both Cho and Cr (p < 0.01). We report for the first time that premature birth is associated with altered cerebellar metabolite profiles when compared to term born controls. Infection, cerebellar injury and supratentorial injury are important risk factors for impaired preterm cerebellar biochemistry.