Medicine and Health Sciences Commons^™

A Review Of Macrolide Based Regimens For Community-Acquired Pneumonia, Forest W. Arnold, Leslie A. Beavin

The University of Louisville Journal of Respiratory Infections

Community-acquired pneumonia (CAP) has significant morbidity and mortality. The Infectious Diseases Society of America/American Thoracic Society (IDSA/ATS) guidelines recommend two antimicrobial regimens for hospitalized patients with CAP, one of which includes a macrolide, and one of which does not. Both regimens have antimicrobial properties, but macrolides also possess immunomodulatory properties. Macrolides, however, may also have potential arrhythmia adverse effects. The purpose of this review is to provide an update of studies evaluating outcomes for patients with CAP treated with or without a macrolide-based regimen. Two recent randomized controlled trials conflict with each other regarding the benefit versus noninferiority of including …

Modelling Fatigue For Management Decision Making: A Case Study, Rajee Olaganathan, Timothy B. Holt, Jacqueline Luedtke

Publications

Fatigue is one major contributing factor that reduces the human ability and leads to accidents, and threatens the safety of aircraft and human lives.

Though fatigue is seen in all the disciplines associated with the aviation industry, this paper will discuss only pilot fatigue. Based on the literature examined, this study first examines the significance of the problem.

Investigation of the inflight, pre/post flight countermeasures (both pharmacological and non - pharmacological methods) practiced at present, discusses the Fatigue Risk Management System (FRMS) – in this first, it defines the FRMS, briefly discusses its history, describes the organizational structure of FRMS …

Week Of January 30, 2017, New York Medical College

InTouch

• Twenty-First Annual Medical Student Research Forum Set for February 9
• National Library of Medicine Exhibit Special Presentation

Analisis Biaya Akibat Sakit Serta Kualitas Hidup Pasien Diabetes Mellitus Tipe 2 Dengan Penyakit Jantung, Lusiani Septika Sari

Jurnal Ekonomi Kesehatan Indonesia

Indonesia is the fourth most deaths due diabetes mellitus and heart disease among south Asia countries. Cost of illness from diabetes mellitus with heart disease is the highest cost if it is compared with combination of diabetes mellitus with other chronic disease. This study with 110 patients as samples is aiming to describing the cost of illness and quality of life of patients with type 2 diabetes mellitus with heart disease in X public hospital. With cross sectional research design, primary data is collected with survey technique that uses structured questionnaire and secondary data is obtained through medical record document …

Portal Protein Functions Akin To A Dna-Sensor That Couples Genome-Packaging To Icosahedral Capsid Maturation., Ravi K. Lokareddy, Rajeshwer S. Sankhala, Ankoor Roy, Pavel V. Afonine, Tina Motwani, Carolyn M M. Teschke, Kristin N. Parent, Gino Cingolani

Department of Biochemistry and Molecular Biology Faculty Papers

Tailed bacteriophages and herpesviruses assemble infectious particles via an empty precursor capsid (or 'procapsid') built by multiple copies of coat and scaffolding protein and by one dodecameric portal protein. Genome packaging triggers rearrangement of the coat protein and release of scaffolding protein, resulting in dramatic procapsid lattice expansion. Here, we provide structural evidence that the portal protein of the bacteriophage P22 exists in two distinct dodecameric conformations: an asymmetric assembly in the procapsid (PC-portal) that is competent for high affinity binding to the large terminase packaging protein, and a symmetric ring in the mature virion (MV-portal) that has negligible affinity …

An Analysis Of The Hospital Bylaws Policies To Protect Healthcare Workers Against Indictments Of Adverse Events, Ade Leana, Adang Bachtiar

Journal of Indonesian Health Policy and Administration

One of the functions of hospital bylaws are a means to provide legal protection for all all parties that are related to the hospital. Legal protection is essential for prosecuted hospital staff members. One of the reasons for indictments is adverse events. The goal of this research is to discover how the hospital by-laws protects the hospital staff in the event of an indictment based on an adverse event and how the by-laws adhere to the guidelines in a comprehensive way. The research design used the qualitative method. The results of this research indicates that the hospital by-laws of RSKO …

Strategi Pemasaran Pelayanan Continuous Ambulatory Peritoneal Dialysis Di Klinik Khusus Ginjal X Batam Tahun 2016, Bertha Toha, Vetty Y Ulianty Permanasari

Jurnal Ekonomi Kesehatan Indonesia

Currently only 53% of patients with end-stage renal disease that can access dialysis and mostly get Hemodialysis (HD), whereas the cost to Continous Ambulatory Peritoneal Dialysis (CAPD) cheaper than HD (Ministry of Health, 2016). Services of CAPD in Clinic for Kidney Disease X. Batam began since 2010, but the number of CAPD patients only 3% of the end stage renal disease patients there. The purpose of this study to analyze the Marketing Strategy of Continuous Ambulatory Peritoneal Dialysis Services at the Clinic for Kidney Disease X Batam Year 2016. The design of the study is an analytic descriptive with quantitative …

Medical School Watercooler Newsletter - January 29, 2017, Lindsey Lyle

Watercooler Newsletter

This is the January 29, 2017 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

Dr. Brooks Cash Named Chief of the Division of Gastroenterology

USA Welcomes Dr. John Gosche

President of American Academy of Pediatrics Presents Grand Rounds Lecture

USA Medical Students Get Hands-On Experience in Geriatric Care

Sleep Spindles And Intellectual Ability: Epiphenomenon Or Directly Related?, Zhuo Fang, Valya Sergeeva, Laura B. Ray, Adrian M. Owen, Stuart M. Fogel

Anatomy and Cell Biology Publications

Sleep spindlesshort, phasic, oscillatory bursts of activity that characterize non-rapid eye movement sleepare one of the only electrophysiological oscillations identified as a biological marker of human intelligence (e.g., cognitive abilities commonly assessed using intelligence quotient tests). However, spindles are also important for sleep maintenance and are modulated by circadian factors. Thus, the possibility remains that the relationship between spindles and intelligence quotient may be an epiphenomenon of a putative relationship between good quality sleep and cognitive ability or perhaps modulated by circadian factors such as morningness-eveningness tendencies. We sought to ascertain whether spindles are directly or indirectly related to cognitive …

Caries Prevalence In Maine Based On College Of Dental Medicine (Une) Findings, Molly A. Kalish, Vasiliki Maseli

Dental Medicine Student Research Posters

Poster presentation outlining a retrospective study conducted in order to better understand the needs of Maine residents and provide the appropriate oral health care in the future.

Background and Overview: Dental caries is a progressive, irreversible microbial disease affecting the hard tissues of the tooth. It is the most prevalent chronic disease affecting the human race. Once it occurs, its manifestations persist throughout life even when the lesion is treated. It usually begins soon after the teeth erupt into the oral cavity, thus, it is a post eruptive disease. It affects people of both genders, all races, all ages, and …

Improving Medication Use For Project Home Residents In An Urban Setting, Toni Campanella, Pharmd Candidate, Ashley Maister, Pharmd Candidate, Roshni S. Patel, Pharmd, Bcps

College of Pharmacy Posters

Partners:

Project HOME is a non-profit organization in Philadelphia that provides housing, employment opportunities, medical care, and education to those who are homeless or at risk of becoming homeless, including those with a history of serious mental health or substance misuse disorders.

Jefferson College of Pharmacy students are dedicated to transforming the health and well-being of the community. By engaging in innovative opportunities, students are well-positioned to deliver patient-centered care.

APhA-ASP serves as the collective voice of student pharmacists to provide opportunities for professional growth, to improve patient care, and to envision and advance the future of pharmacy.

Establishing Sustainable Community Garden Interventions With Aid From Health Promotion Organizations, Rachel Joann Buenemann

Theses and Dissertations

Community garden interventions provide policy, system and environmental change at the community level to establish health behaviors, which act in contest to obesity risk factors. Limited research examines factors, which influence the sustainability of community garden interventions. Therefore, in this study, a sample of 10 Midwestern community gardens associated through funding from a health promotion organization in 2013, collected data through the interviewing and surveying of 10 garden administrators and surveying of 12 garden volunteers. The study identified garden benefits perceived by garden administrators and volunteers to include contributions to social justice, continued education, enhanced social cohesion, increased access to …

Sodium-Myoinositol Cotransporter-1, Smit1, Mediates The Production Of Reactive Oxygen Species Induced By Hyperglycemia In The Heart, Anne Van Steenbergen, Magali Balteau, Audrey Ginion, Laura Ferté, Sylvain Battault, Christophe De Meester De Ravenstein, Jean-Luc Balligand, Evangelos-Panagiotis Daskalopoulos, Patrick Gilon, Florin Despa, Sanda Despa, Jean-Louis Vanoverschelde, Sandrine Horman, Hermann Koepsell, Gerard Berry, Louis Hue, Luc Bertrand, Christophe Beauloye

Pharmacology and Nutritional Sciences Faculty Publications

Hyperglycemia (HG) stimulates the production of reactive oxygen species in the heart through activation of NADPH oxidase 2 (NOX2). This production is independent of glucose metabolism but requires sodium/glucose cotransporters (SGLT). Seven SGLT isoforms (SGLT1 to 6 and sodium-myoinositol cotransporter-1, SMIT1) are known, although their expression and function in the heart remain elusive. We investigated these 7 isoforms and found that only SGLT1 and SMIT1 were expressed in mouse, rat and human hearts. In cardiomyocytes, galactose (transported through SGLT1) did not activate NOX2. Accordingly, SGLT1 deficiency did not prevent HG-induced NOX2 activation, ruling it out in the cellular response to …

2017 Founders' Day, Philadelphia College Of Osteopathic Medicine

Founders Day Programs

The 2017 Founders Day Alumni Association Certificate of Honor Recipient was Dana C. Shaffer (DO '85). The OJ Snyder Memorial Medal recipient was Vincent G. Lobo (DO '65). The Philadelphia Campus Mason W. Pressly Memorial Medal Recipient was Anna Elisa Muzio (DO '17). The Georgia campus Mason W. Pressly Memorial Medal Recipient was Matthew Shelnutt (DO '17).

Health & Kinesiology News, Georgia Southern University

Health Sciences & Kinesiology: News & Publications (2015-2023)

• College of Health and Human Sciences’ Faculty Attend NAKHE

Do Healthcare Professionals With High Weight Biases Provide Different Quality Of Care To Obese Compared To Normal Weight Patients?, Justine Leigh Seymour

Theses and Dissertations

Though weight bias has been acknowledged in the health field, it is less understood if and how weight bias affects quality of care. The purpose of this study was to determine if weight bias exhibited by healthcare professionals (HCPs) impacts quality of healthcare provided to obese individuals. HCPs (n=220; 88% female, 87% nurses) in the Midwest region of the United States were recruited to complete an online survey. Participants completed the Attitude Towards Obese Persons scale (ATOP) to assess weight bias and responded to hypothetical patient scenarios to evaluate quality of care. A median split was calculated for ATOP scores …

Reading Comprehension Through Incidental Learning: Efficacy Of An After-School Literacy Program Utilizing The Barton Reading & Spelling System®, Sarah L. Gearhart

Student Theses and Dissertations

This study investigated reading comprehension gains through incidental learning for students participating in an after-school program utilizing the Barton Reading & Spelling System®. Participants included 78 students enrolled in a public school system in Northeast Arkansas. These students were compared to peers with similar reading difficulties who did not participate in the program. Reading comprehension gains through incidental learning were determined for all participants based upon national and state standardized assessment measures (e.g., Iowa Test of Basic Skills® (ITBS®), Stanford Achievement Test, Tenth Edition (SAT-10), and the Arkansas Augmented Benchmark Examination (AABE)). No differences in performance were found between the …

Speech-Language Pathology Graduate Students' Perceptions Of Cultural Competency Experiences, Ragen Elizabeth Bray

Student Theses and Dissertations

This study utilized a 19-item survey to investigate whether graduate SLP students understand the spectrum of skills necessary to become “culturally competent,” and to assess the number and types of formal and informal activities used to achieve cultural competency instruction in the speech-language pathology curriculum. Graduate students enrolled in five accredited graduate programs for Communication Disorders in the state of Arkansas responded to the survey. Overall, results indicated that accredited university speech-language pathology programs in Arkansas are attempting to implement opportunities for expanding cultural awareness and sensitivity for their students. However, the results from the survey indicate that these programs …

Effectiveness Of Video Modeling As An Intervention Technique For Broca’S Aphasia, Elizabeth Dryer

Student Theses and Dissertations

The purpose of this study was to compare the efficacy of video modeling to clinician modeling in the clinical setting for individuals with non-fluent Broca's aphasia and apraxia of speech. Words and phrases were targeted for each treatment approach. During 25 minute sessions, each participant was asked to spontaneously say the target words when given the target words in writing. Data were collected each session in terms of speed and accuracy of productions. Scores for 19 sessions for participant 1 and scores for 21 sessions for participant 2 were used for analysis. Paired Samples t-tests were conducted to examine each …

Influences Of An After-School Literacy Program: A Barton Reading & Spelling System® Efficacy Study, April Dawn Morgan

Student Theses and Dissertations

The purposes of this study were to examine how many levels of the Barton Reading and Spelling System® (BRSS®) should be completed in order to achieve a target normative score on standardized tests which measure literacy skills, and to examine the efficacy of an after-school literacy program by comparing a group of similar students who did not participate. Standardized tests used were the Arkansas Benchmark Examination Literacy Subtest (ABLS) and the Stanford Achievement Test, Tenth Edition English Language Arts Subtest (SAT-10 ELA). Average scores for students in the experimental group did not reflect target normative scores within the time frame …

Comparison Of Testosterone Replacement Therapy Medications For Treatment Of Hypogonadism, Karlen Beth Luthy, Chris Williams, Donna S. Freeborn, Aaron Cook

Faculty Publications

Testosterone replacement therapy (TRT) is one treatment option for men with hypogonadism. When TRT is prescribed, effectiveness, patient compliance, cost, and potential side effects should be considered and utilized to develop an individualized treatment plan. Depo-testosterone is the most cost-efficient TRT option and is only administered every 2 weeks which may improve patient compliance, although the dose interval can be adjusted to once per week. Androderm is the most efficacious TRT medication, with up to 92% of patients reaching normal testosterone levels. Testim and Vogelxo have the fewest reported side effects. We recommend depo-testosterone as a first line treatment option.

Teft Fasi Alpha Test Report, Barbara Gage, Trudy Mallinson, Laurie Lyons, Joyce Maring, Ken Harwood, Anju Paude, Alex Gorsky, Beth Jackson, Pat Rivard, Lisa Gold, Allison Weaver, Kerry Lida

Physical Therapy and Health Care Sciences Faculty Publications

No abstract provided.

From Emt To Hsc To Aml: Zeb2 Is A Cell Fate Switch., Sara E. Meyer

Department of Cancer Biology Faculty Papers

In this issue of Blood, complimentary studies by J. Li et al¹ and H. Li et al² identify the transcription factor ZEB2 as a critical regulator of multilineage differentiation in both normal and malignant hematopoiesis. In particular, these studies show that ZEB2 is an inhibitor of normal granulocyte production, and in acute myeloid leukemia (AML), antagonizing ZEB2 function releases the granulocytic differentiation block, creating an antileukemic therapeutic effect.

Neurovascular Astrocyte Degeneration In The Hyperhomocysteinemia Model Of Vascular Cognitive Impairment And Dementia (Vcid), Tiffany L. Sudduth, Erica M. Weekman, Brittani Rae Price, Jennifer L. Gooch, Abigail E. Woolums, Christopher M. Norris, Donna M. Wilcock

Sanders-Brown Center on Aging Faculty Publications

Vascular cognitive impairment and dementia (VCID) is the second leading cause of dementia behind Alzheimer’s disease (AD) and is a frequent co-morbidity with AD. Despite its prevalence, little is known about the molecular mechanisms underlying the cognitive dysfunction resulting from cerebrovascular disease. Astrocytic end-feet almost completely surround intraparenchymal blood vessels in the brain and express a variety of channels and markers indicative of their specialized functions in the maintenance of ionic and osmotic homeostasis and gliovascular signaling. These functions are mediated by end-foot enrichment of the aquaporin 4 water channel (AQP4), the inward rectifying potassium channel Kir4.1 and the calcium-dependent …

Evaluation Of A Community-Based Positive Youth Development Program For Adolescents With Greater Psychosocial Needs: Views Of The Program Participants, Daniel T. L. Shek, Cecilia M. S. Ma, Moon Y. M. Law, Zoe Zhao

Pediatrics Faculty Publications

The present study attempted to investigate the perceptions of Chinese secondary school students with greater psychosocial needs of the Tier 2 Program in the community-based phase of P.A.T.H.S. Project in Hong Kong (n=4245). Using a subjective outcome evaluation tool (Form C), the results revealed that a great majority of the students held positive attitudes toward the program, implementers and the effectiveness of the program. Also, the three domains of the program (“program quality”, “implementer quality” and “program effectiveness”) were significantly associated with each other. In line with previous findings, both program content and program implementer quality were significant predictors of …

Conjugated Linoleic Acid Administration Induces Amnesia In Male Sprague Dawley Rats And Exacerbates Recovery From Functional Deficits Induced By A Controlled Cortical Impact Injury, Rastafa I. Gedde, Kentaro Hayashi, Quinn Bongers, Marlyse Wehber, Icelle M. Anderson, Alex D. Jansen, Chase Nier, Emily Fares, Gabrielle Farquhar, Amita Kapoor, Toni E. Ziegler, Sivan Vadakkadath Meethal, Ian M. Bird, Craig S. Atwood

Research outputs 2014 to 2021

Long-chain polyunsaturated fatty acids like conjugated linoleic acids (CLA) are required for normal neural development and cognitive function and have been ascribed various beneficial functions. Recently, oral CLA also has been shown to increase testosterone (T) biosynthesis, which is known to diminish traumatic brain injury (TBI)-induced neuropathology and reduce deficits induced by stroke in adult rats. To test the impact of CLA on cognitive recovery following a TBI, 5–6 month old male Sprague Dawley rats received a focal injury (craniectomy + controlled cortical impact (CCI; n = 17)) or Sham injury (craniectomy alone; n = 12) and were injected with …

Orthopaedic Surgeon Density In West Virginia, Franklin D. Shuler, Grant S. Buchanan, Zachary Sanford, Milad Modarresi, James Timothy Reagan, Kelly Scott, Chad Fisher, Ali Oliashirazi

Marshall Journal of Medicine

Abstract

West Virginia (WV) has many healthcare disparities and access barriers. For bone and joint disorders, WV has some of the highest rates of musculoskeletal problems, including the highest reported rate of adult arthritis in the nation (36.2%). We hypothesized that WV has one of the lowest Orthopaedic surgeon densities in the country, which can negatively impact the delivery of musculoskeletal care. Using the WV Board of Medicine practitioner databank, the Veterans Administration practitioner data, and national Orthopaedic surgeon census data, we demonstrated a considerably low Orthopaedic surgeon density in WV (7.71/100,000 population versus the national average of 8.51/100,000 population) …

The Development Of A Novel Interprofessional Education Curriculum For Third Year Medical And Pharmacy Students, Christine L. Gilkerson, Rebecca M. Hayes, Leesa Prunty, James Aaron Sizemore, Shannon Browning, Robert B. Stanton, Kevin W. Yingling

Marshall Journal of Medicine

Abstract

Introduction:

The Liaison Committee on Medical Education and the Accreditation Council for Pharmacy Education, agencies responsible for the accreditation of medical and pharmacy schools respectively, require interprofessional education (IPE) to be integrated into both curricula. Institutions are given the autonomy to design and implement this requirement, however research is equivocal in regards to when and how best to implement IPE. The development of a new IPE curriculum is often met with a number of challenges, such as a lack of faculty support and resources.

Methods:

This study describes a newly created pilot IPE curriculum developed with minimal existing organizational …

Self-Reported Tobacco Use And Correlation With Umbilical Cord Blood Cotinine Levels At Delivery Among Appalachian Gravidas, Jesse Cottrell, Brenda L. Mitchell, Pooja N. Sangani, D'Andrea S. Thomas, Monica A. Valentovic

Marshall Journal of Medicine

The detrimental effects of cigarette use during pregnancy are well documented. Studies have shown that cigarette smoking while pregnant is associated with multiple adverse outcomes including: pre-term birth, placental abruption, placenta previa, fetal growth restriction, stillbirth, increased rate of birth defects, and increased risk of sudden infant death syndrome. Cotinine is the primary metabolite of nicotine and allows for measurement of active as well as passive exposure. Cotinine freely cross the placental barrier and maternal concentrations are closely correlated with newborn plasma levels. The aim of this study was to compare maternally reported rates of tobacco use to fetal umbilical …

Changes In Rural Affinity Among Rural Medical Students As They Experience Education In An Urban Setting, William J. Crump, Craig H. Ziegler, Leslee J. Martin, R. Steve Fricker, M. Ann Shaw, Alllison M. Crump, Susan Sawning

Marshall Journal of Medicine

Abstract

Introduction

The maldistribution of physicians in the United States has led to a shortage of healthcare providers in rural areas and rural patients being underserved. A physician’s connections to rural settings, including upbringing and medical training, often influence the decision to practice in rural areas. This study examines opinions from medical students who participated in a regional rural campus track, which includes summer immersion programs, rural-focused sessions, and clinical rotations. The authors hypothesized that Rural Track students experience urban disruption, and their opinions about rural living and practice would become increasingly less positive over time while students lived at …