Medicine and Health Sciences Commons^™

Antegrade Versus Retrograde Nailing Techniques And Trochanteric Versus Piriformis Intramedullary Nailing Entry Points For Femoral Shaft Fractures: A Systematic Review And Meta-Analysis, Nasir Hussain, Farrah Naz Hussain, Corey Sermer, Hera Kamdar, Emil H. Schemitsch, Amir Sternheim, Paul Kuzyk

Bone and Joint Institute

© 2017 Joule Inc. or its licensors. Background: There are several different techniques commonly used to perform intramedullary (IM) nailing of the femur to fix femoral fractures. We sought to identify significant differences in outcomes of studies comparing 1) trochanteric and piriformis entry and 2) antegrade and retrograde entry in IM nailing of the femur. Methods: We searched MEDLINE, Cochrane and Embase databases and the Orthopaedic Trauma Association and American Academy of Orthopaedic Surgeons websites for comparative studies published from inception to November 2015. Criteria used to select articles for detailed review included use of antegrade and retrograde entry point …

Adolescent Cannabinoid Exposure Induces A Persistent Sub-Cortical Hyper-Dopaminergic State And Associated Molecular Adaptations In The Prefrontal Cortex., Justine Renard, Laura G Rosen, Michael Loureiro, Cleusa De Oliveira, Susanne Schmid, Walter J Rushlow, Steven R Laviolette

Brain and Mind Institute Researchers' Publications

Considerable evidence suggests that adolescent exposure to delta-9-tetrahydrocanabinol (THC), the psychoactive component in marijuana, increases the risk of developing schizophrenia-related symptoms in early adulthood. In the present study, we used a combination of behavioral and molecular analyses with in vivo neuronal electrophysiology to compare the long-term effects of adolescent versus adulthood THC exposure in rats. We report that adolescent, but not adult, THC exposure induces long-term neuropsychiatric-like phenotypes similar to those observed in clinical populations. Thus, adolescent THC exposure induced behavioral abnormalities resembling positive and negative schizophrenia-related endophenotypes and a state of neuronal hyperactivity in the mesocorticolimbic dopamine (DA) pathway. …

Skilled Adult Readers Activate The Meanings Of High-Frequency Words Using Phonology: Evidence From Eye Tracking., Debra Jared, Katrina O'Donnell

Brain and Mind Institute Researchers' Publications

We examined whether highly skilled adult readers activate the meanings of high-frequency words using phonology when reading sentences for meaning. A homophone-error paradigm was used. Sentences were written to fit 1 member of a homophone pair, and then 2 other versions were created in which the homophone was replaced by its mate or a spelling-control word. The error words were all high-frequency words, and the correct homophones were either higher-frequency words or low-frequency words-that is, the homophone errors were either the subordinate or dominant member of the pair. Participants read sentences as their eye movements were tracked. When the high-frequency …

Guideline For Radiotherapy With Curative Intent In Patients With Early-Stage Medically Inoperable Non-Small-Cell Lung Cancer, Conrad Falkson, E Vella, Edward Yu, M El-Mallah, R Mackenzie, P Ellis, Y Ung

Data and Test Instruments

ABSTRACTObjectives For this guideline, we investigated the effectiveness of radiotherapy with curative intent in medicallyinoperable patients with early-stage non-small-cell lung cancer (nsclc).Methods The guideline was developed by Cancer Care Ontario’s Program in Evidence-Based Care and by theLung Cancer Disease Site Group through a systematic review of mainly retrospective studies, expert consensus, andformal internal and external reviews.Recommendations Stereotactic body radiation therapy (sbrt) with curative intent is an option that should be considered for patientswith early-stage, node-negative, medically inoperable nsclc.Qualifying Statements Because of the high dose per fraction, the planning process and treatment delivery for sbrt require theuse of advanced technology to …

Accuracy Of Seizure Identification By Critical Care Providers Using Quantitative Eeg Displays, Saptharishi Lalgudi Ganesan, Craig Stewart, Eshetu Atenafu, Roy Sharma, Jamie Hutchison, Anne-Marie Guerguerian, Cecil Hahn

Data and Test Instruments

No abstract provided.

Current Methods Of Evaluating Speech-Language Outcomes For Preschoolers With Communication Disorders: A Scoping Review Using The Icf-Cy, Barbara Jane Cunningham, Karla N. Washington, Amanda Binns, Katelyn Rolfe, Bernadette Robertson, Peter Rosenbaum

PRECISe Preschool Speech and Language Publications

Purpose: The purpose of this scoping review was to identify current measures used to evaluate speech-language outcomes for preschoolers with communication disorders within the framework of the International Classification of Functioning, Disability and Health – Children and Youth (ICF-CY) (World Health Organization, 2007). Method: The review included five phases outlined by Arksey and O’Malley (2005) and further developed by Levac et al. 2010: (a) articulating the research question, (b) identifying relevant studies, (c) study selection, (d) charting the data, and (e) collating, summarizing and reporting the results. The WHO ICF-CY was used to frame the measures included. Results: A total …

Understanding The Influence Of Stigma And Discrimination For The Functional Limitation Severity - Psychological Distress Relationship: A Stress And Coping Perspective, Robyn Lewis Brown

Sociology Faculty Publications

No abstract provided.

Mitochondria Mediate Cell Membrane Repair And Contribute To Duchenne Muscular Dystrophy., Maria C Vila, Sree Rayavarapu, Marshall W Hogarth, Jack H Van Der Meulen, Adam Horn, Aurelia Defour, Shin'ichi Takeda, Kristy J. Brown, Yetrib Hathout, Kanneboyina Nagaraju, Jyoti K. Jaiswal

Genomics and Precision Medicine Faculty Publications

Dystrophin deficiency is the genetic basis for Duchenne muscular dystrophy (DMD), but the cellular basis of progressive myofiber death in DMD is not fully understood. Using two dystrophin-deficient mdx mouse models, we find that the mitochondrial dysfunction is among the earliest cellular deficits of mdx muscles. Mitochondria in dystrophic myofibers also respond poorly to sarcolemmal injury. These mitochondrial deficits reduce the ability of dystrophic muscle cell membranes to repair and are associated with a compensatory increase in dysferlin-mediated membrane repair proteins. Dysferlin deficit in mdx mice further compromises myofiber cell membrane repair and enhances the muscle pathology at an asymptomatic …

Pediatric High-Grade Glioma: Biologically And Clinically In Need Of New Thinking., Chris Jones, Matthias A Karajannis, David T W Jones, Mark W Kieran, Michelle Monje, Suzanne J Baker, Roger J Packer, +Several Additional Authors

Neurology Faculty Publications

High-grade gliomas in children are different from those that arise in adults. Recent collaborative molecular analyses of these rare cancers have revealed previously unappreciated connections among chromatin regulation, developmental signaling, and tumorigenesis. As we begin to unravel the unique developmental origins and distinct biological drivers of this heterogeneous group of tumors, clinical trials need to keep pace. It is important to avoid therapeutic strategies developed purely using data obtained from studies on adult glioblastoma. This approach has resulted in repetitive trials and ineffective treatments being applied to these children, with limited improvement in clinical outcome. The authors of this perspective, …

Cold Atmospheric Plasma, A Novel Promising Anti-Cancer Treatment Modality., Dayun Yan, Jonathan H Sherman, Michael Keidar

Neurological Surgery Faculty Publications

Over the past decade, cold atmospheric plasma (CAP), a near room temperature ionized gas has shown its promising application in cancer therapy. Two CAP devices, namely dielectric barrier discharge and plasma jet, show significantly anti-cancer capacity over dozens of cancer cell lines in vitro and several subcutaneous xenograft tumors in vivo. In contrast to conventional anti-cancer approaches and drugs, CAP is a selective anti-cancer treatment modality. Thus far establishing the chemical and molecular mechanism of the anti-cancer capacity of CAP is far from complete. In this review, we provide a comprehensive introduction of the basics of CAP, state of the …

Pcsk9 Genetic Variants And Risk Of Type 2 Diabetes: A Mendelian Randomisation Study, A. Schmidt, D. Swerdlow, M. Holmes, R. Patel, Z. Fairhurst-Hunter, Cara L. Carty, +Several Additional Authors

Pediatrics Faculty Publications

BACKGROUND:

Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk.

METHODS:

In this mendelian randomisation study, we used data from cohort studies, randomised controlled trials, case control studies, and …

Mechanism For Generation Of Left Isomerism In Ccdc40 Mutant Embryos, Kelsey Sugrue, Irene E. Zohn

Pediatrics Faculty Publications

Leftward fluid flow in the mouse node is generated by cilia and is critical for initiating asymmetry of the left-right axis. Coiled-coil domain containing-40 (Ccdc40) plays an evolutionarily conserved role in the assembly of motile cilia and establishment of the left-right axis. Approximately one-third of Ccdc40lnks mutant embryos display situs defects and here we investigate the underlying mechanism. Ccdc40lnks mutants show delayed induction of markers of the left-lateral plate mesoderm (L-LPM) including Lefty1, Lefty2 and Nodal. Consistent with defective cilia motility compromising fluid flow across the node, initiation of asymmetric perinodal Cerberus like-2 ( …

Building On The Supplemental Nutrition Assistance Program’S Success: Conquering Hunger, Improving Health, Neal D. Barnard, David Katz

Medicine Faculty Publications

No abstract provided.

Bridging The Divide White Paper: Pregnant Women And Substance Use: Overview Of Research & Policy In The United States, Darla Bishop, Liz Borkowski, Megan Couillard, Amy Allina, Susanna Baruch, Susan Wood

Jacobs Institute of Women's Health

This paper examines the current literature and policy implications of substance use and substance use disorders among pregnant and parenting women. While this is not meant to serve as an exhaustive literature review on this topic, it seeks to describe: current research on health effects of substance use and substance use disorders on pregnant women1 and their children; policies and programs that help ensure that pregnant women who use substances have access to the highest quality healthcare, including prenatal care; the current barriers to accessing treatment for substance use disorders for pregnant women, including those who are incarcerated; and the …

Impact Of Sequencing Targeted Therapies With High-Dose Interleukin-2 Immunotherapy: An Analysis Of Outcome And Survival Of Patients With Metastatic Renal Cell Carcinoma From An On-Going Observational Il-2 Clinical Trial: Proclaim, Joseph I Clark, Michael K K Wong, Howard L Kaufman, Gregory A Daniels, Michael A Morse, David F Mcdermott, Sanjiv S Agarwala, Lionel D Lewis, John H Stewart, Ulka Vaishampayan, Brendan Curti, René Gonzalez, Jose Lutzky, Venkatesh Rudraptna, Lee D Cranmer, Joanne M Jeter, Ralph J Hauke, Gerald Miletello, Mohammed M Milhem, Asim Amin, John M Richart, Mayer Fishman, Sigrun Hallmeyer, Sapna P Patel, Peter Van Veldhuizen, Neeraj Agarwal, Bret Taback, Jonathan S Treisman, Marc S Ernstoff, Jessica C Perritt, Hong Hua, Tharak B Rao, Janice P Dutcher, Sandra Aung

Articles, Abstracts, and Reports

BACKGROUND: This analysis describes the outcome for patients who received targeted therapy (TT) prior to or following high-dose interleukin-2 (HD IL-2).

PATIENTS AND METHODS: Patients with renal cell carcinoma (n = 352) receiving HD IL-2 were enrolled in Proleukin

RESULTS: Overall, there were 4% complete response (CR), 13% partial response (PR), 39% stable disease (SD), and 43% progressive disease (PD) with HD IL-2. The median overall survival (mOS) was not reached in patients with CR, PR, or SD, and was 15.5 months in patients with PD (median follow-up, 21 months). Sixty-one patients had prior TT before HD IL-2 with an …

The Need For Standardized Assessment Of Muscle Quality In Skeletal Muscle Function Deficit And Other Aging-Related Muscle Dysfunctions: A Symposium Report, Rosaly Correa De Araujo, Michael O. Harris-Love, Iva Miljkovic, Maren Fragala, Brian Anthony, Todd Manini

Exercise and Nutrition Sciences Faculty Publications

A growing body of scientific literature suggests that not only changes in skeletal muscle mass, but also other factors underpinning muscle quality, play a role in the decline in skeletal muscle function and impaired mobility associated with aging. A symposium on muscle quality and the need for standardized assessment was held on April 28, 2016 at the International Conference on Frailty and Sarcopenia Research in Philadelphia, Pennsylvania. The purpose of this symposium was to provide a venue for basic science and clinical researchers and expert clinicians to discuss muscle quality in the context of skeletal muscle function deficit and other …

Eccentric Exercise Program Design: A Periodization Model For Rehabilitation Applications, Michael O. Harris-Love, Bryant Seamon, Tomas I. Gonzales, Haniel J. Hernandez, Donte Pennington, Brian Hoover

Exercise and Nutrition Sciences Faculty Publications

The applied use of eccentric muscle actions for physical rehabilitation may utilize the framework of periodization. This approach may facilitate the safe introduction of eccentric exercise and appropriate management of the workload progression. The purpose of this data-driven Hypothesis and Theory paper is to present a periodization model for isokinetic eccentric strengthening of older adults in an outpatient rehabilitation setting. Exemplar and group data are used to describe the initial eccentric exercise prescription, structured familiarization procedures, workload progression algorithm, and feasibility of the exercise regimen. Twenty-four men (61.8 ±6.3 years of age) completed a 12-week isokinetic eccentric strengthening regimen involving …

Infection Control In Labor And Delivery Room, Learning From The Small Hospital Based Project, Savera Aziz Ali, Sumera Aziz Ali

School of Nursing & Midwifery

Background: It has been estimated that around 36% of the neonatal deaths occur due to infection in the lower and middle income countries. Infection control is a more substantial area of concern, particularly in Labor and delivery room. Multiple factors can cause infection in the labor room, therefore it is important to assess various factors of maternal and neonatal infection. Hence we explored multiple factors through this project and developed the action plan to address those factors effectively.
Methods: During our Leadership and Management course, we conducted a project in Labor room pertaining to a prevalent issue. The whole process …

Prescription Opioid Abuse In Chronic Pain: An Updated Review Of Opioid Abuse Predictors And Strategies To Curb Opioid Abuse (Part 2), Alan David Kaye, Mark R. Jones, Adam M. Kaye, Juan G. Ripoll, Donald E. Jones, Vincent Galan, Burton D. Beakley, Francisco Calixto, Jamie L. Bolden, Richard D. Urman, Laxmaiah Manchikanti

School of Pharmacy Faculty Articles

Chronic pain and prescription opioid abuse are extremely prevalent in the United States and worldwide. The consequences of opioid misuse can be life-threatening with significant morbidity and mortality, exacting a heavy toll on patients, physicians, and society. The risk for misuse of prescribed opioids is much higher in patients with chronic pain, especially those with concurrent substance use and /or mental health disorders. Several reasons can account for the occurrence of opioid abuse and misuse, including self-medication, use for reward, compulsive use related to addiction, and diversion for profit. There is a need, therefore, for therapeutic approaches that balance treating …

Responsible, Safe, And Effective Prescription Of Opioids For Chronic Non-Cancer Pain: American Society Of Interventional Pain Physicians (Asipp) Guidelines, Laxmaiah Manchikanti, Adam M. Kaye, Nebojsa Nick Knezevic, Heath Mcanally, Andrea M. Trescot, Susan Blank, Vidyasagar Pampati, Salahadin Abdi, Jay S. Grider, Alan David Kaye, Kavita N. Manchikanti, Harold J. Cordner, Christopher G. Gharibo, Michael E. Harned, Sheri L. Albers, Sairam Atluri, Steve M. Aydin, Sanjay Bakshi, Robert Barkin, Ramsin M. Benyamin, Mark V. Boswell, Ricardo M. Buenaventura, Aaron K. Calodney, David L. Cedeno, Sukdeb Datta, Timothy R. Deer, Bert Fellows, Vincent Galan, Vahid Grami, Hans Hansen, Standiford Helm

School of Pharmacy Faculty Articles

Background: Opioid use, abuse, and adverse consequences, including death, have escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse, numerous regulations and guidelines for responsible opioid prescribing have been developed by various organizations. However, the US opioid epidemic is continuing and drug dose deaths tripled during 1999 to 2015. Recent data show a continuing increase in deaths due to natural and semisynthetic opioids, a decline in methadone deaths, and an explosive increase in the rates of deaths involving other opioids, specifically heroin and illicit synthetic fentanyl. Contrary to scientific evidence of efficacy and negative …

Potential Ciliary Neurotrophic Factor Application In Dental Stem Cell Therapy, Patrick Suezaki, Nan (Tori) Xiao

All Dugoni School of Dentistry Faculty Articles

Neurotrophic factors have long been considered growth factors that promote survival and growth of various neuronal tissues. Recent studies showed that neurotrophic factors are also present in dental pulp and periodontal ligament. This paper reviews the literature about the ciliary neurotrophic factor (CNTF), a member of the neurotrophic factor family, and indicates the potential clinical application of CNTF in dental stem cell therapy.

Prescription Opioid Abuse In Chronic Pain: An Updated Review Of Opioid Abuse Predictors And Strategies To Curb Opioid Abuse: Part 1, Alan David Kaye, Mark R. Jones, Adam M. Kaye, Juan G. Ripoll, Vincent Galan, Burton D. Beakley, Francisco Calixto, Jamie L. Bolden, Richard D. Urman, Laxmaiah Manchikanti

School of Pharmacy Faculty Articles

Chronic pain and prescription opioid abuse are extremely prevalent both in this country and worldwide. Consequences of opioid misuse can be life-threatening with significant morbidity and mortality, exacting a heavy toll on patients, physicians, and society. Individuals with chronic pain and co-occurring substance use disorders and/or mental health disorders, are at a higher risk for misuse of prescribed opioids. Opioid abuse and misuse occurs for a variety of reasons, including self-medication, use for reward, compulsive use because of addiction, and diversion for profit. There is a significant need for treatment approaches that balance treating chronic pain; while minimizing risks for …

Bcl-W Has A Fundamental Role In B Cell Survival And Lymphomagenesis., Clare M. Adams, Annette S. Kim, Ramkrishna Mitra, John K Choi, Jerald Z. Gong, Christine M. Eischen

Department of Cancer Biology Faculty Papers

Compromised apoptotic signaling is a prerequisite for tumorigenesis. The design of effective therapies for cancer treatment depends on a comprehensive understanding of the mechanisms that govern cell survival. The antiapoptotic proteins of the BCL-2 family are key regulators of cell survival and are frequently overexpressed in malignancies, leading to increased cancer cell survival. Unlike BCL-2 and BCL-XL, the closest antiapoptotic relative BCL-W is required for spermatogenesis, but was considered dispensable for all other cell types. Here, however, we have exposed a critical role for BCL-W in B cell survival and lymphomagenesis. Loss of Bcl-w conferred sensitivity to growth factor deprivation-induced …

Acceptability Of Hiv Testing Sites Among Rural And Urban African Americans Who Use Cocaine, D. Keith Branham, Tyrone F. Borders, Katharine E. Stewart, Geoffrey M. Curran, Brenda M. Booth

Health Management and Policy Faculty Publications

African Americans (AAs) who use cocaine in the Southern region of the U.S. have a relatively high risk of HIV and need for HIV testing. Among this group, those residing in rural areas may have less favorable opinions about common HIV testing sites, which could inhibit HIV testing. We examined rural/urban variations in their acceptability of multiple HIV testing sites (private physician clinic, local health department, community health center, community HIV fair, hospital emergency department, blood plasma donation center, drug abuse treatment facility, and mobile van or community outreach worker). Results from partial proportional odds and logistic regression analyses indicate …

Creating Enabling Environment For Student Engagement: Faculty Practices Of Critical Thinking, Shanaz Hussein Cassum, Raisa B. Gul

School of Nursing & Midwifery

Critical thinking (CT) is considered an important attribute in practice disciplines and faculty members in nursing, medicine, and education are expected to facilitate the development of CT in their graduates so that these individuals can be critical, reflective, competent, and caring professionals and service providers (Distler, 2007; Shiau & Chen, 2008; Worell & Profetto-McGrath, 2007). When students are actively engaged in their learning, and classrooms have an enabling environment, critical thinking is promoted. Teachers must reflect upon their teaching pedagogy when students do not participate in stimulating discussions, or asks questions in class. Research suggests that lack of understanding of …

Assessment Of Childhood Domestic Injuries Among Joint And Nuclear Families Of Karachi, Asif Khaliq, Amreen Rao, Shahroz Siddiqui, Ghulam Mujtaba Nasir

Department of Biological & Biomedical Sciences

To assess the frequencies and factors of domestic injuries among children aged less than 5 years. This is a cross sectional study, in which parents who have child less than 5 years of age were targeted. A total of 246 participants had provided satisfactory information and they were approached by non-probability purposive sampling technique from January 2016 to June 2016. The data was entered in Excel and then imported to SPSS 19.0 for inferential analysis. In this study, 89.8% (n = 221) mothers and 10.2% (n = 25) father who had participated. 52.08% (n = 123) parents were from joint …

The Influence Of Tumor Regression, Solar Elastosis, And Patient Age On Pathologists' Interpretation Of Melanocytic Skin Lesions., Linda Titus, Raymond L Barnhill, Jason P Lott, Michael W Piepkorn, David E Elder, Paul D Frederick, Heidi D Nelson, Patricia A Carney, Stevan R Knezevich, Martin A Weinstock, Joann G Elmore

Articles, Abstracts, and Reports

It is not known whether patient age or tumor characteristics such as tumor regression or solar elastosis influence pathologists' interpretation of melanocytic skin lesions (MSLs). We undertook a study to determine the influence of these factors, and to explore pathologist's characteristics associated with the direction of diagnosis. To meet our objective, we designed a cross-sectional survey study of pathologists' clinical practices and perceptions. Pathologists were recruited from diverse practices in 10 states in the United States. We enrolled 207 pathologist participants whose practice included the interpretation of MSLs. Our findings indicated that the majority of pathologists (54.6%) were influenced toward …

A Longitudinal Examination Of Parental Psychological Control And Externalizing Behavior In Adolescents With Adolescent Internalized Shame As A Mediating Variable, Iesha Renee Nuttall

Theses and Dissertations

The purpose of this study was to examine the relationship between parental psychological control and adolescent externalizing behavior with adolescent internalized shame acting as a mediating variable. Gender differences were also examined. Three hundred eleven two-parent families with an adolescent were included in this study, 154 were male adolescents (Mean age at wave 6 = 16.28 years, SD = .98) and 157 were female adolescents (Mean age at wave 6 = 16.21 years, SD = .99). Results indicate that parental psychological control for both mothers and fathers at wave 4 was positively related to adolescent externalizing behavior for both boys …

From Guidelines To Local Realities: Evaluation Of Oral Rehydration Therapy And Zinc Supplementation In Guatemala, Rachel Hall-Clifford, Roxanne Amerson

Publications

Objectives: Diarrhea remains a leading cause of morbidity and mortality for children in low- and middle-income countries throughout the Americas. WHO guidelines have been developed to incorporate zinc supplementation (ZS) with traditional oral rehydration therapy (ORT) to shorten duration and reduce poor health outcomes. Guatemala adopted these guidelines in 2011, but they have not yet been fully implemented at the community level. The objectives of this study were to co-design an ORT/ZS training program with community health promoters appropriate to the local context and to understand how training with the promoters changes attitudes and behaviors of community members.

Methods: In …

Stress And Child Development: A Review Of The Family Stress Model, April S. Masarik, Rand D. Conger

Psychological Sciences Faculty Publications and Presentations

In the present report, we provide an illustrative review of the Family Stress Model (FSM) framework¹ to understand how family stress influences children across development in physical, social-emotional, and cognitive domains. We note that the FSM as a theory has evolved through inspection of: (a) new explanatory pathways (mediators); (b) factors that moderate FSM pathways; and (c) joint tests of competing models. Also important, most researchers cited in this review used longitudinal designs to test the proposed causal ordering of FSM pathways, which replicated among a diverse set of families varied in structure, ethnic background, and geographic location. We …