Medicine and Health Sciences Commons^™

Zika Virus Encoding Nonglycosylated Envelope Protein Is Attenuated And Defective In Neuroinvasion, Arun Saravanakumar Annamalai, Aryamav Pattnaik, Bikash R. Sahoo, Ezhumalai Muthukrishnan, Sathish Kumar Natarajan, David Steffen, Hiep Vu, Gustavo A. Delhon, Fernando Osorio, Thomas M. Petro, Shi-Hua Xiang, Asit K. Pattnaik

School of Veterinary and Biomedical Sciences: Faculty Publications

ABSTRACT Zika virus (ZIKV), a mosquito-transmitted flavivirus responsible for sporadic outbreaks of mild and febrile illness in Africa and Asia, reemerged in the last decade causing serious human diseases, including microcephaly, congenital malformations, and Guillain-Barré syndrome. Although genomic and phylogenetic analyses suggest that genetic evolution may have led to the enhanced virulence of ZIKV, experimental evidence supporting the role of specific genetic changes in virulence is currently lacking. One sequence motif, VNDT, containing an N-linked glycosylation site in the envelope (E) protein, is polymorphic; it is absent in many of the African isolates but present in all isolates from the …

Privacy Risks And Security Threats In Mhealth Apps, Brinda Hansraj Sampat, Bala Prabhakar

Journal of International Technology and Information Management

mHealth (Mobile Health) applications (apps) have transformed the doctor-patient relationship. They help users with varied functionalities such as monitoring their health, understanding specific health conditions, consulting doctors online and achieving fitness goals. Whilst these apps provide an option of equitable and convenient access to healthcare, a lot of personal and sensitive data about users is collected, stored and shared to achieve these functionalities. Little is known about the privacy and security concerns these apps address. Based on literature review, this paper identifies the privacy risks and security features for evaluating thirty apps in the Medical category across two app distribution …

Serum Microrna-27b As A Screening Biomarker For Left Ventricular Hypertrophy, Yan Wang, Shuyan Chen, Yanhong Gao, Song Zhang

The Texas Heart Institute Journal

MicroRNA-27b (miR-27b) is frequently upregulated in pressure-overloaded hypertrophic hearts. The clinical implications of aberrant circulating miR-27b in the diagnosis and management of left ventricular hypertrophy warrant study. We investigated whether serum miR-27b is a biomarker for left ventricular hypertrophy (LVH).

We used stem-loop reverse-transcription quantitative polymerase chain reaction techniques to analyze serum miR-27b levels in 200 hypertensive patients with LVH, 100 hypertensive patients without LVH, and 100 healthy volunteers. We found that serum miR-27b levels were significantly higher in the hypertensive patients with LVH than in the hypertensive patients without LVH and in the healthy volunteers. Upon receiver operating characteristic …

A Blueprint For Life And Love, Marilyn Todd

The Texas Heart Institute Journal

No abstract provided.

Widespread Theta Synchrony And High-Frequency Desynchronization Underlies Enhanced Cognition., E. A. Solomon, J. E. Kragel, Michael R. Sperling, Ashwini Sharan, G. Worrell, M. Kucewicz, C. S. Inman, B. Lega, K. A. Davis, J. M. Stein, B. C. Jobst, K. A. Zaghloul, S. A. Sheth, D. S. Rizzuto, M. J. Kahana

Department of Neurology Faculty Papers

The idea that synchronous neural activity underlies cognition has driven an extensive body of research in human and animal neuroscience. Yet, insufficient data on intracranial electrical connectivity has precluded a direct test of this hypothesis in a whole-brain setting. Through the lens of memory encoding and retrieval processes, we construct whole-brain connectivity maps of fast gamma (30-100 Hz) and slow theta (3-8 Hz) spectral neural activity, based on data from 294 neurosurgical patients fitted with indwelling electrodes. Here we report that gamma networks desynchronize and theta networks synchronize during encoding and retrieval. Furthermore, for nearly all brain regions we studied, …

Evaluation Of Perampanel As Monotherapy For Focal Seizures: Experience From Open-Label Extension Studies, Patrick Kwan, Scott Mintzer, Antonio Laurenza, Anna Patten, Karen Cartwright, Formerly: Eisai Ltd.

Department of Neurology Faculty Papers

Perampanel, a selective, non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, is approved for adjunctive treatment of focal seizures, with or without secondarily generalized seizures, and for primary generalized tonic–clonic seizures in patients with epilepsy aged ≥ 12 years. Perampanel was recently approved for monotherapy use for focal seizures in the U.S.A. Anti-seizure drug monotherapy may be preferable to polytherapy, which is generally associated with increased toxicity, non-compliance, and cost. Here, we report cases where patients had converted to perampanel monotherapy during open-label extension (OLEx) portions of 9 Phase II and III studies. Of 2245 patients who enrolled in the OLEx studies, …

Idiopathic Nodular Glomerulosclerosis In A Chronic Marijuana User; A Case Report And Review Of The Literature, Mehri Mollaee, Tibor Fülöp, Sohil Abdul Salim, Seyed Mehrdad Hamrahian

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background: Nodular glomerulosclerosis is a characteristic histological finding of diabetic nephropathy (DN) with thickened glomerular basement membrane (GBM) and hyalinized arterioles. Idiopathic nodular glomerulosclerosis (ING), a rare distinct clinicopathologic entity, is the term used to denote classic DN confirmed by light microscopy, immuno-fluorescence, and electron microscopy in the absence of diabetes mellitus (DM). ING has been linked to heavy tobacco smoking, chronic hypertension, obesity and insulin resistance. Its association with marijuana use is unknown. Case Presentation: We report a case of biopsy-proved ING in the absence of pre-existing history of DM and heavy smoking. This report addresses the possible accentuation …

How Should Clinicians Weigh The Benefits And Harms Of Discussing Politicized Topics That Influence Their Individual Patients' Health?, Diana Alame, Robert D. Truog

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Health implications of politically charged phenomena are particularly difficult for physicians to discuss with their patients and communities. Addressing climate change and its associated health effects involves trade-offs between health and economic prosperity, necessitating that physicians weigh the potential benefits and risks of discussing climate change health effects. We argue that the potential benefits of physician communication and advocacy ultimately outweigh the potential risks. Therefore, physicians should be supported in their efforts to educate their patients and communities about climate change health effects. Furthermore, democratic deliberation could prove helpful in addressing disagreements among physicians within a practice about such politicized …

The Positive Thinking Skills Scale: A Screening Measure For Early Identification Of Depressive Thoughts, Abir K. Bekhet, Mauricio Garnier-Villarreal

College of Nursing Faculty Research and Publications

Background

Depression is currently considered the second leading cause of disability worldwide. Positive thinking is a cognitive process that helps individuals to deal with problems more effectively, and has been suggested as a useful strategy for coping with adversity, including depression. The Positive Thinking Skills Scale (PTSS) is a reliable and valid measure that captures the frequency of use of positive thinking skills that can help in the early identification of the possibility of developing depressive thoughts. However, no meaningful cutoff score has been established for the PTSS.

Aim

To establish a cutoff score for the PTSS for early identification …

Autism And Research Using Magnetic Resonance Imaging, Norah L. Johnson, Nicole M.G. Salowitz, Michael Van Abel, Bridget Dolan, Amy V. Van Hecke, Sheikh Iqbal Ahamed

College of Nursing Faculty Research and Publications

This qualitative study explored the experience of participating in a research study using magnetic resonance imaging (MRI) for children with autism spectrum disorder (ASD), typically developing (TYP) children, and their parent. It also assessed the feasibility, efficacy, and acceptability of the Going to MRI for a Research Study© iPad application (app), developed by the primary author, available for use for MRI preparation. The app provides a description of the steps of the MRI procedure, from the child’s perspective, outlining expected behaviors and responses. Ten English-speaking parent/child dyads (n = 20) participated in an audiotaped question guide-facilitated telephone interview about …

Examination Of The Role Of Religious And Psychosocial Factors In Hiv Medication Adherence Rates, Safiya George Dalmida, Katryna Mccoy, Harold C. Koenig, Aretha Miller, Marcia Mcdonnell Holstad, Tami Thomas, Dora L. Clayton-Jones, Mary Margaret Grant, Terri Fleming, Menka Munira Wirani, George Mugoya

College of Nursing Faculty Research and Publications

Optimal adherence to antiretroviral therapy (ART) is associated with favorable HIV outcomes, including higher CD4 cell counts, HIV virus suppression and a lower risk of HIV transmission. However, only 25% of people living with HIV/AIDS (PLWH) in the USA are virally suppressed. Sub-optimal adherence (p< 0.05). Social support satisfaction was also significantly associated with ART adherence (OR = 1.52, 95% CI [1.11–2.08], p < 0.05) and energy/fatigue/vitality (OR = 1.03, 95% CI [1.00–1.05], p < 0.05).

Hypertrophic Cardiomyopathy With Aortic Dilation: A Novel Observation, Ryan Yousefzai, Anushree Agarwal, M. Fuad Jan, Chi Cho, Michael Anigbogu, Kambiz Shetabi, Maharaj Singh, Michelle Bush, Shannon Treiber, Steven Port, Khawaja Afzal Ammar, Timothy E. Paterick, Renuka Jain, Bijoy K. Khandheria, A. Jamil Tajik

College of Nursing Faculty Research and Publications

Aims Our goal was to identify the prevalence of aortic dilation in patients with hypertrophic cardiomyopathy (HCM), the most prevalent (0.2%) heritable, genetic cardiovascular disease. Aortic dilation also represents a spectrum of familial inheritance. However, data regarding the prevalence of aortic dilation in HCM patients is lacking. Methods and results This is an observational retrospective study of all patients referred to our HCM centre. Aortic dilation was defined based on recent American Society of Echocardiography and European Association of Cardiovascular Imaging published guidelines. Of the 201 HCM patients seen between Jan. 1, 2011 and March 31, 2014, 18 (9.0%) met …

Effects Of Direction Time Constraints And Walking Speed On Turn Strategies And Gait Adaptations In Healthy Older And Young Adults, Dennis Torre

Seton Hall University Dissertations and Theses (ETDs)

Hip fractures can be life-threatening, debilitating, and costly. The odds for hip fracture increases from impact of sideways falls. While turning has been strongly associated with hip fracture & sideways falls, the distinction between the risks for walking-turns as opposed to low-velocity in-place turning is not clear. The present study sought to fill a gap as previous research had not compared walking-turn performance in young & healthy older adults at low-fall risk within the same study and response-conditions of speed interacting with direction-cue time constraints. Spatial-temporal variables representative of AP braking/propulsion (i.e. stride-length & speed) & ML stability (left/right H-H …

Comparison Of Expression Of The Gdnf Family Neurotrophic Factors In Dental Pulp Stem Cells With Deciduous And Adult Teeth, Kamille Mercado, Nan (Tori) Xiao

All Dugoni School of Dentistry Faculty Articles

The glial cell line-derived neurotrophic factor (GDNF) family has a role in neuron growth within the peripheral and central nervous systems. This makes it a potential therapeutic agent for neurological conditions like Parkinson’s disease and epilepsy. GDNF has also been implicated in murine odontogenesis. In permanent and deciduous human dental pulp stem cells, this study found that GDNF family members and receptors are expressed, indicating neurotrophic factors may play a role in dental pulp regeneration.

A Review Of Occupation And Impairment Based Assessments Used In Occupational Therapy, Mariana D'Amico

OCCUPATION: A Medium of Inquiry about Health through Occupation

Objective: The objective of this paper was to analyze the psychometrics, efficacy, and usefulness of assessments to measure occupational performance and occupation-based outcomes.

Methodology: Eight Doctor of Occupational Therapy Students at Nova Southeastern University, along with their professor, analyzed and appraised 46 commonly used assessments to discover and explore the assessments’ purposes, theory-bases, psychometric properties, and usefulness as outcome measures.

Results: We found that many high quality assessments exist and meet the standards for validity and reliability. Although some assessments are client-centered and useful, some still require additional research to strengthen their psychometric properties.

Conclusion: Some widely used assessments …

What Happens After The Nicu? Parents Experience Of Caring For Their Premature Infants At Home, Amanda Pignon

OCCUPATION: A Medium of Inquiry about Health through Occupation

This paper reviews the literature on what happens after the NICU with premature babies and their families and provides perspective of a lived experience. There have been numerous studies conducted on the traumatic experience of the NICU, however there is limited research involving the parenting process and experience following the NICU and caring for a high risk infant at home. Articles were searched through two databases, CINAHL and Pubmed, yielding 15 articles in which three specific themes were outlined; psychological distress of parents, perceptions of parents and linking family to resources. While there are programs available for families, not all …

The Occupational Experiences Of Lesbian, Gay, Bisexual And Transgender (Lgbt) Individuals During The Coming Out Process: An Analysis Of Self-Acceptance, Disclosure, And Occupational Change, Lee Meach

OCCUPATION: A Medium of Inquiry about Health through Occupation

Human occupation is an intensely individual process that is colored by the cultural and life experiences of the individual who is engaged in an activity. The experiences of gender and sexual minorities typically defined as Lesbian, Gay, Bisexual, and Transgender (LGBT) individuals are different in many ways from the rest of the population. One occupation unique to this community is the process of “coming out” in which the individual discloses their minority sexual orientation or gender identity to others. The coming out process is complex and multi-faceted, involving both the internal reflective process of first self-accepting one’s orientation and identity …

Effects Of Asenapine On Agitation And Hostility In Adults With Acute Manic Or Mixed Episodes Associated With Bipolar I Disorder, Leslie L. Citrome, R Landbloom, C Chang, W Earley

NYMC Faculty Publications

BACKGROUND:

Bipolar disorder is associated with an increased risk of aggression. However, effective management of hostility and/or agitation symptoms may prevent patients from becoming violent. This analysis investigated the efficacy of the antipsychotic asenapine on hostility and agitation in patients with bipolar I disorder.

METHODS:

Data were pooled from three randomized, double-blind, placebo-controlled, Phase III trials of asenapine in adults with manic or mixed episodes of bipolar I disorder (NCT00159744, NCT00159796, and NCT00764478). Post hoc analyses assessed the changes from baseline to day 21 on the Young Mania Rating Scale (YMRS) and the Positive and Negative …

A Qualitative Study Of Group Therapy Incorporating Rap Music With Inmates, Abigail V. Richards

Graduate Theses/Dissertations

This study aims to explore the lived experiences of inmates who participate in group psychotherapy incorporating elements of rap music. Rap music includes elements such as emotional expression, songwriting, community building, freestyling, and beat, which can be beneficial for individuals experiencing typical symptoms of incarceration such as anxiety, self-discovery, and difficulties regulating emotion. Ten inmates of a Missouri county justice center (50% male) were recruited on a volunteer basis to participate in a five-week psychotherapy group. The study involves psychoeducation, group-drumming, self-expression, and improvisation. Qualitative data were collected through an interview process with participants, including inmates, facilitators and supervisors. Results …

Role Of Race/Ethniciy, Pre-Pregnancy Bmi, And Socioeconomic Status On Risk For Large-For-Gestational (Lga) Infants Born To Women With Gestational Diabetes Mellitus (Gdm), Anna M. Kiefer

Masters Theses

Background Fetal macrosomia occurs in approximately 10% of all pregnancies taking place in the United States. Babies born LGA are placed at a greater risk for shoulder dystocia, perinatal trauma, cesarean section, jaundice, hypoglycemia, and neonatal intensive care admission. Even more, the long-term impacts are severe and include increased risk of becoming overweight or obese and developing type 2 diabetes later in life. Women with gestational diabetes mellitus (GDM) have higher rates of delivering macrosomic offspring due to insulin resistance taking place beyond what is normal during a pregnancy. Additionally, maternal obesity, socioeconomic status, and race/ethnicity have been associated with …

The Effect Of Dietary Specialism And Generalism On Evolutionary Longevity In An Early Paleogene Mammalian Community, Samantha Glonek

Masters Theses

This study examines the relationship between relief index (RFI) on first and second mandibular molars and longevity of the genus. The molars were extracted from small-bodied, arboreal mammals during the late-Paleocene, early-Eocene in the Bighorn Basin in Wyoming. This study site is a well-known location to research and study fossil mammals of this time period. The study was conducted and analyzed at the genus level due to the relatively small number of specimens available and identifiable at the species level. Dietary breadth, or how broad or narrow a dietary preference is for a mammal, is an area of concentration within …

Prevalence Of Psychiatric Morbidity In A Community Sample In Western Kenya, Edith Kwobah, Steve Epstein, Ann Mwangi, Debra Litzelman, Lukoye Atwoli

Internal Medicine, East Africa

Background:About 25% of the worldwide population suffers from mental, neurological and substance use disorders but unfortunately, up to 75% of affected persons do not have access to the treatment they need. Data on the magnitude of the mental health problem in Kenya is scarce.

The objectives of this study were to establish the prevalence and the socio-demographic factors associated with mental and substance use disorders in Kosirai division, Nandi County, Western Kenya.

Methods:This was a cross sectional descriptive study in which participants were selected by simple random sampling. The sampling frame was obtained from a data base of …

Discovery, Research, And Development Of New Antibiotics: The Who Priority List Of Antibiotic-Resistant Bacteria And Tuberculosis, Evelina Tacconelli, Elena Carrara, Alessia Savoldi, Stephan Harbarth, Marc Mendelson, Dominique L. Monnet, Celine Pulcini, Gunnar Kahlmeter, Jan Kluytmans, Yehuda Carmeli, Marc Ouellette, Kevin Outterson, Jean Patel, Marco Cavaleri, Edward M. Cox, Chris R. Houchens, M Lindsay Grayson, Paul Hansen, Nalini Singh, Ursula Theuretzbacher, Nicola Magrini, Who Pathogens Priority List Working Group

Faculty Scholarship

Summary

Background The spread of antibiotic-resistant bacteria poses a substantial threat to morbidity and mortality worldwide. Due to its large public health and societal implications, multidrug-resistant tuberculosis has been long regarded by WHO as a global priority for investment in new drugs. In 2016, WHO was requested by member states to create a priority list of other antibiotic-resistant bacteria to support research and development of effective drugs.

Methods We used a multicriteria decision analysis method to prioritise antibiotic-resistant bacteria; this method involved the identification of relevant criteria to assess priority against which each antibiotic-resistant bacterium was rated. The final priority …

A Phenomenological Investigation Of Pharmacists' Experiences, Motivation, And Preferences In The Context Of Continuing Pharmacy Education, Laura Beth Ladymon

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe select Tennessee pharmacists’ experiences, motivation, and preferences in the context of continuing pharmacy education (CPE). The pharmacists’ experiences, motivation, and preferences related to CPE were generally defined as participating in CPE programming in a manner that meets the needs of the pharmacist. Also, select pharmacists were defined as pharmacists with at least six hours of continuing pharmacy education credit within the last year. This study explored how 12 pharmacist participants in Tennessee experienced CPE as well as what motivated them to attend CPE activities. Additionally, the study investigated pharmacists’ preferences in …

Computational Identification Of Noncoding Driver Mutations Based On Impact On Rna Processing, Kevin Zhu

Dissertations and Theses (Open Access)

Despite the prevalence of mutations in the noncoding regions of the DNA, their effects on cancer development remain largely uninvestigated. This is especially evident when compared to coding mutations, which have been relatively well-studied and, in certain cases, been identified as driver mutations for cancer. Recent studies, however, have identified noncoding mutations that frequently appear in certain types of cancer, which may be evidence that those mutations are important to cancer development. Nonetheless, the role of noncoding mutations in cancer remains unclear. A potential vector for understanding this mechanism is through observing the relation between noncoding mutations and functional RNA …

Integrative Cancer Immunogenomic Analysis Of Serial Melanoma Biopsies Reveals Correlates Of Response And Resistance To Sequential Ctla-4 And Pd-1 Blockade Treatment, Whijae Roh

Dissertations and Theses (Open Access)

Melanoma is the most malignant form of skin cancer. The five-year survival rate for metastatic melanoma is 19.9%. Although targeted therapy of BRAF and MEK inhibitors were developed for melanoma, resistance to therapy is inevitable. Immune checkpoint blockade, which reverses the suppression of the immune system, on the other hand, has shown a durable response in 20-30% of patients with metastatic melanoma. However, more predictive and robust biomarkers of response to this therapy are still needed, and resistance mechanisms remain incompletely understood. To address this, we examined a cohort of metastatic melanoma patients treated with sequential checkpoint blockade against cytotoxic …

Memory Potential, Molecular Characterization, And Translational Applications Of The Novel Theo/Tceo T Cell Phenotype, Todd Bartkowiak, Todd Bartkowiak

Dissertations and Theses (Open Access)

T cells comprise a substantial arm of the immune system and are exquisitely adapted to combat pathogens and tumors. The inflammatory environment largely dictates the nature of T cell response. A hallmark of T cell-mediated immunity is formation of immunological memory; the ability to respond more potently to re-encounter with pathogens. The immune system is also capable of recognizing tumors as foreign, much like viral or bacterial pathogens. Tumors have evolved, though, to generate an immunosuppressive environment to avoid destruction. The field of immunotherapy seeks to overcome immune suppression, in part by targeting T cell co-receptors on the cell surface …

Impact Of Kras/Nras Mutational Heterogeneity On Clinical Outcomes In Colorectal Cancer, Jonathan M. Loree

Dissertations and Theses (Open Access)

Introduction: Mutations in KRAS/NRAS (RAS) predict a lack of benefit from anti-EGFR agents in metastatic colorectal cancer (mCRC). As next generation sequencing (NGS) has advanced, we are discovering atypical and low allele frequency mutations. We aimed to evaluate how NGS can optimally define RAS mutant CRC and the role of relative mutant allele frequency (rMAF) as a biomarker.

Methods: Using institutional and public cohorts of mCRC patients with NGS results, we described the prevalence and clinical impact of atypical (not in current guidelines) and low rMAF RAS mutations (RAS MAF by the MAF of the mutated gene with …

Quality Of Life: Socio-Demographic And Genetic Determinants As Well As Links With Cancer Outcomes, Jeanne Pierzynski

Dissertations and Theses (Open Access)

Quality of life (QOL) is an independent prognostic factor for cancer. Lung cancer is the leading cause of cancer death. Breast cancer is the most diagnosed. Bladder cancer is the most expensive cancer to treat because of its high recurrence rate. We set to perform comprehensive analyses of predictors of QOL in these cancer sites with the future goal of improving QOL and outcomes.

In 6,456 newly diagnosed lung cancer patients, we investigated the relationship between baseline patient characteristics and QOL to identify determinants of QOL. A QOL questionnaire (SF-12v1) measured patients’ physical component summary (PCS) and mental component summary …

Dynamic Assessment Of Nk Cell Interactions With Pediatric Tumor Cells To Predict Response To Immunotherapy, Arianexys Aquino Lopez

Dissertations and Theses (Open Access)

Due to Natural Killer (NK) cells’ capacity to target tumor cells without prior sensitization, adoptive NK cell therapy represents a promising immunotherapy approach for pediatric cancer patients. Our laboratory has developed an NK cell expansion protocol that generates large quantities of NK cells for therapeutic infusion. Given that NK cells are heterogeneous, with variable receptor expression and potential to target tumor cells, the purpose of my study was to determine whether subpopulations of NK cells with enhanced anti-tumor potential could be identified for increased potency of the NK cell infusion product. In addition, we previously showed that our expanded NK …