Medicine and Health Sciences Commons^™

Cool-Associated Tyrosine-Phosphorylated Protein 1 Is Required For The Anchorage-Independent Growth Of Cervical Carcinoma Cells By Binding Paxillin And Promoting Akt Activation., Sungsoo M. Yoo, Arash Latifkar, Richard A. Cerione, Marc A. Antonyak

Department of Biochemistry and Molecular Biology Faculty Papers

Cool-associated tyrosine-phosphorylated protein 1 (Cat-1) is a signaling scaffold as well as an ADP-ribosylation factor-GTPase-activating protein. Although best known for its role in cell migration, we recently showed that the ability of Cat-1 to bind paxillin, a major constituent of focal complexes, is also essential for the anchorage-independent growth of HeLa cervical carcinoma cells. Here we set out to learn more about the underlying mechanism by which Cat-paxillin interactions mediate this effect. We show that knocking down paxillin expression in HeLa cells promotes their ability to form colonies in soft agar, whereas ectopically expressing paxillin in these cells inhibits this …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern Examines Sleep in Families with Children
• Georgia Southern Receives Grant to Survey Mosquito Control Capacity

Epidemiology News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• Georgia Southern Examines Sleep in Families with Children

Environmental Health News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• Georgia Southern Receives Grant to Survey Mosquito Control Capacity

Structured Study Abroad Enhances Intercultural Competence, Lata A. Krishnan, Christi Masters, Horane Holgate, Cong Wang, Charles A. Calahan

Teaching and Learning in Communication Sciences & Disorders

Participation in a service-learning (SL) study abroad (SA) program has been shown to enhance cultural competence (Krishnan, Richards & Simpson, 2016) as measured via the Public Affairs Scale (PAS; Levesque-Bristol & Cornelius-White, 2012). The purpose of this study was 1) to evaluate students’ development of intercultural competence using the Intercultural Development Inventory (IDI®), a tool specifically designed for this purpose, and 2) to evaluate whether intentionally escalating culturally focused developmental experiential learning together with existing course content would increase cultural competence more than program participation alone. Thirty female and one male student participated over three years of the SL SA …

Speech-Language Pathology Students’ Perceptions Of An Ipe Stroke Workshop: A One-Year Follow Up, Sarah E. Wallace

Teaching and Learning in Communication Sciences & Disorders

Interprofessional education (IPE) activities are increasingly included in speech-language pathology (SLP) curriculum; however, little is known about IPE’s impact on students’ clinical experiences. Additionally, few studies have examined students’ perceptions of IPE Competency Domains across a program of study or within specific IPE activities. For this initial study, qualitative and quantitative analyses of 24 SLP students’ survey responses one year after an IPE Stroke Workshop highlighted the value of IPE. Students emphasized the importance of hands on and real life activities as part of interprofessional learning. Additionally, their responses suggest that multiple IPE Competency Domains may be addressed within a …

Na/K-Atpase Signaling And Salt Sensitivity: The Role Of Oxidative Stress, Jiang Liu, Yanling Yan, Ying Nie

Biochemistry and Microbiology

Other than genetic regulation of salt sensitivity of blood pressure, many factors have been shown to regulate renal sodium handling which contributes to long-term blood pressure regulation and have been extensively reviewed. Here we present our progress on the Na/K-ATPase signaling mediated sodium reabsorption in renal proximal tubules, from cardiotonic steroids-mediated to reactive oxygen species (ROS)-mediated Na/K-ATPase signaling that contributes to experimental salt sensitivity.

Postnatal Betamethasone Decreases Respiratory Index In Ventilated Extremely Low Birth Weight Neonates Compared To Conventional Care, Yuanyi Murray, Sanjeet Panda, Dina Finkel, Vanessa Mercado, Edmund F. La Gamma

NYMC Faculty Posters

No abstract provided.

Upsurge Of Enterovirus D68 Infection In The Lower Hudson Valley, New York, 2016, Taliya Farooq, Esther C. Yoon, Jian Zhuge, Changhong Yin, Wei-Hua Huang, Sheila M. Nolan, John T. Fallon, Guiqing Wang

NYMC Faculty Posters

No abstract provided.

Hyper-Methylated Loci Persisting From Sessile Serrated Polyps To Serrated Cancers, Angeline S. Andrew, John A. Baron, Lynn F. Butterfly, Arief A. Suriawinata, Gregory J. Tsongalis, Christina M. Robinson, Christopher I. Amos

Dartmouth Scholarship

Although serrated polyps were historically considered to pose little risk, it is now understood that progression down the serrated pathway could account for as many as 15%–35% of colorectal cancers. The sessile serrated adenoma/polyp (SSA/P) is the most prevalent pre-invasive serrated lesion. Our objective was to identify the CpG loci that are persistently hyper-methylated during serrated carcinogenesis, from the early SSA/P lesion through the later cancer phases of neoplasia development. We queried the loci hyper-methylated in serrated cancers within our rightsided SSA/Ps from the New Hampshire Colonoscopy Registry, using the Illumina Infinium Human Methylation 450 k panel to comprehensively assess …

Roadmap To A Comprehensive Clinical Data Warehouse For Precision Medicine Applications In Oncology, David J. Foran, Wenjin Chen, Huiqi Chu, Evita Sadimin, Doreen Loh, Gregory Riedlinger, Lauri A. Goodell, Shridar Ganesan, Kim Hirshfield, Lorna Rodriguez, Robert S. Dipaola

Internal Medicine Faculty Publications

Leading institutions throughout the country have established Precision Medicine programs to support personalized treatment of patients. A cornerstone for these programs is the establishment of enterprise-wide Clinical Data Warehouses. Working shoulder-to-shoulder, a team of physicians, systems biologists, engineers, and scientists at Rutgers Cancer Institute of New Jersey have designed, developed, and implemented the Warehouse with information originating from data sources, including Electronic Medical Records, Clinical Trial Management Systems, Tumor Registries, Biospecimen Repositories, Radiology and Pathology archives, and Next Generation Sequencing services. Innovative solutions were implemented to detect and extract unstructured clinical information that was embedded in paper/text documents, including synoptic …

Smoking Trends Among U.S. Latinos, 1998–2013: The Impact Of Immigrant Arrival Cohort, Georgiana Bostean, Annie Ro, Nancy L. Fleischer

Sociology Faculty Articles and Research

Few studies examine nativity disparities in smoking in the U.S., thus a major gap remains in understanding whether immigrant Latinos’ smoking prevalence is stable, converging, or diverging, compared with U.S.-born Latinos. This study aimed to disentangle the roles of period changes, duration of U.S. residence, and immigrant arrival cohort in explaining the gap in smoking prevalence between foreign-born and U.S.-born Latinos. Using repeated cross-sectional data spanning 1998–2013 (U.S. National Health Interview Survey), regressions predicted current smoking among foreign-born and U.S.-born Latino men and women (n = 12,492). We contrasted findings from conventional regression analyses that simply include period and duration …

Dueling Biological And Social Contagions, Feng Fu, Nicholas A. Christakis, James H. Fowler

Dartmouth Scholarship

Numerous models explore how a wide variety of biological and social phenomena spread in social networks. However, these models implicitly assume that the spread of one phenomenon is not affected by the spread of another. Here, we develop a model of “dueling contagions”, with a particular illustration of a situation where one is biological (influenza) and the other is social (flu vaccination). We apply the model to unique time series data collected during the 2009 H1N1 epidemic that includes information about vaccination, flu, and face-to-face social networks. The results show that well- connected individuals are more likely to get vaccinated, …

Patients Receiving Androgen Deprivation Therapy For Prostate Cancer Have An Increased Risk Of Depressive Disorder, Shiu-Dong Chung, Li-Ting Kao, Herng-Ching Lin, Sudha Xirasagar Mbbs., Ph.D., Chung-Chien Huang, Hsin-Chien Lee

Publications

Androgen deprivation therapy (ADT) results in testosterone suppression, a hypothesized mechanism linking ADT to depressive symptoms. This study investigated the relationship between ADT and the risk of subsequently being diagnosed with depressive disorder (DD) during a 3-year follow-up period. The patient sample for this population-based, retrospective cohort study was retrieved from the Taiwan Longitudinal Health Insurance Database 2005. We included all 1714 patients aged over 40 years with a first-time diagnosis of prostate cancer (PC) during 2001 to 2010 who did not have an orchiectomy. Among them, we defined 868 patients who received ADT during the 3-year follow-up period as …

What Is The Contribution Of Ia-Afference For Regulating Motor Output Variability During Standing?, Niklas König Ignasiak

Physical Therapy Faculty Articles and Research

Motor variability is an inherent feature of all human movements, and describes the system‘s stability and rigidity during the performance of functional motor tasks such as balancing. In order to ensure successful task execution, the nervous system is thought to be able to flexibly select the appropriate level of variability. However, it remains unknown which neurophysiological pathways are utilized for the control of motor output variability. In responding to natural variability (in this example sway), it is plausible that the neuro-physiological response to muscular elongation contributes to restoring a balanced upright posture. In this study, the postural sway of 18 …

Transactivation Of The Estrogen Receptor Promoter By Brca1, William B. Archey, Bradley A. Arrick

Dartmouth Scholarship

Background: Absence of the estrogen receptor-α (ER) is perhaps the most distinctive pathological feature of breast cancers arising in women who inherit a mutation in BRCA1. Two hypotheses, not necessarily mutually exclusive, exist in the literature that describe mechanisms of ER transcriptional repression in breast cancer. One hypothesis suggests that methylation of cytosine–guanine dinucleotides (CpGs) primarily mediates repression, while the other maintains that transcriptional control is mediated by certain positive and negative promoter elements.

Methods: To determine if wild type BRCA1 could induce activity of the ER promoter, we performed a series of tran- sient transfections with ER promoter segments …

Development Of A Self‐Management Theory‐Guided Discharge Intervention For Parents Of Hospitalized Children, Kathleen Sawin, Marianne E. Weiss, Norah L. Johnson, Karen Gralton, Shelly Malin, Carol Klingbeil, Stacee M. Lerret, Jamie J. Thompson, Kim Zimmanck, Molly Kaul, Rachel Schiffman

College of Nursing Faculty Research and Publications

Background

Parents of hospitalized children, especially parents of children with complex and chronic health conditions, report not being adequately prepared for self‐management of their child's care at home after discharge.

Problem

No theory‐based discharge intervention exists to guide pediatric nurses' preparation of parents for discharge.

Purpose

To develop a theory‐based conversation guide to optimize nurses' preparation of parents for discharge and self‐management of their child at home following hospitalization.

Methods

Two frameworks and one method influenced the development of the intervention: the Individual and Family Self‐Management Theory, Tanner's Model of Clinical Judgment, and the Teach‐Back method. A team of nurse …

Role Of Corpus Callosum Integrity In Arm Function Differs Based On Motor Severity After Stroke, Jill Campbell Stewart, Pritha Dewanjee, George Tran, Erin Burke Quinlan, Lucy Dodakian, Alison Mckenzie, Jill See, Steven C. Cramer

Physical Therapy Faculty Articles and Research

While the corpus callosum (CC) is important to normal sensorimotor function, its role in motor function after stroke is less well understood. This study examined the relationship between structural integrity of the motor and sensory sections of the CC, as reflected by fractional anisotropy (FA), and motor function in individuals with a range of motor impairment level due to stroke. Fifty-five individuals with chronic stroke (Fugl-Meyer motor score range 14 to 61) and 18 healthy controls underwent diffusion tensor imaging and a set of motor behavior tests. Mean FA from the motor and sensory regions of the CC and from …

Cpt1a Methylation Is Associated With Plasma Adiponectin, S. Aslibekyan, A. N. Do, H. Xu, S. Li, M. R. Irvin, D Zhi, H. K. Tiwari, D. M. Absher, A. R. Shuldiner, T. Zhang, W. Chen, K. Tanner, C. Hong, B. D. Mitchell, G. Berenson, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

Background and Aims—Adiponectin, an adipose-secreted protein that has been linked to insulin sensitivity, plasma lipids, and inflammatory patterns, is an established biomarker for metabolic health. Despite clinical relevance and high heritability, the determinants of plasma adiponectin levels remain poorly understood.

Methods and Results—We conducted the first epigenome-wide cross-sectional study of adiponectin levels using methylation data on 368,051 cytosine-phosphate-guanine (CpG) sites in CD4+ T-cells from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN, n= 991). We fit linear mixed models, adjusting for age, sex, study site, T-cell purity, and family. We have identified a positive association (regression …

Can A Post-Discharge Telephone Call Reduce Hospital Readmission After Colorectal Surgery? A Prospective Study, Daniel Mandel, Karen Zaghiyan, Phillip Fleshner

NYMC Student Posters

BACKGROUND: Hospital readmission after major colorectal surgery is a major economic burden and a benchmark of quality care by government agencies. We hypothesized that a post-discharge telephone follow-up (TFU) could reduce readmission after abdominal colorectal surgery.

METHODS: Consecutive patients undergoing abdominal colorectal surgery over the 4-month period ending Oct 2016 were prospectively evaluated. A structured TFU call during the 4-day period after hospital discharge evaluating the patient’s clinical status and possible interventions to avoid readmission was conducted by a second-year medical student, supervised by two board certified colorectal surgeons. Readmission rates were compared to a control group undergoing …

Healthnet News V.32:No.2 March-April 2017, Wendy Urciuoli

Articles - Patient Care

Linking Connecticut Patients and Families to Reliable Health Information

Effectiveness Of Training Program On Clinical Decision Making Regarding Post-Operative Pain Management In Terms Of Clinical Decision Making Ability Among Nurses In A Tertiary Care Setting, Udupi Dist., Nageshwar V

Manipal College of Nursing, Manipal Theses and Dissertations

No abstract provided.

Health Care Standards For Incarcerated Women In Massachusetts, Beth Williams-Breault

Community of Scholars Day—Posters

The general health care disparities among incarcerated women are vast, although when women are imprisoned, they gain a constitutional right to health care that doesn’t exist outside of prison. However, no federal government body has established national standards for medical care in prisons. This research project serves as a public health policy memo to the Bureau of Child, Adolescent, and Family Health of the Boston Public Health Commission (BPHC) recommending accreditation standards for county and state correctional facilities for women.

Practical Pearl: Community Acquired Pneumonia - March 2017, Harry Hoar

Pediatrics Practical Pearls: Referral Guidelines for Common Problems

No abstract provided.

The Role Of Estradiol Metabolism In Urogenital Schistosomiasis-Induced Bladder Cancer, Nuno Vale, Maria Gouveia, Gabriel Rinaldi, Julio Santos, Lucio Lara Santos, Paul J. Brindley, Jose Correia Da Costa

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Urogenital schistosomiasis is a neglected tropical disease that can lead to bladder cancer. How urogenital schistosomiasis induces carcinogenesis remains unclear, although there is evidence that the human blood fluke Schistosoma haematobium, the infectious agent of urogenital schistosomiasis, releases estradiol-like metabolites. These kind of compounds have been implicated in other cancers. Aiming for enhanced understanding of the pathogenesis of the urogenital schistosomiasisinduced bladder cancer, here we review, interpret, and discuss findings of estradiol-like metabolites detected in both the parasite and in the human urine during urogenital schistosomiasis. Moreover, we predict pathways and enzymes that are involved in the production of these …

Prevention Of Recurrent Affective Episodes Using Extinction Training In The Reconsolidation Window: A Testable Psychotherapeutic Strategy., Robert M Post, Robert Kegan

Psychiatry and Behavioral Sciences Faculty Publications

Stressors may initially precipitate affective episodes, but with sufficient numbers of recurrences, episodes can occur more autonomously. It is postulated the memory engram for these recurrent depressions moves from the conscious representational memory system to the unconscious habit memory system encoded in the striatum. If this were the case, cognitive behavior therapy targeted toward extinction of habit memories could be an effective maneuver for helping reverse the automaticity of affective episode recurrence. Extinction training in the reconsolidation window (which opens about 5 min to 1 h after active memory recall) can revise, reverse, or eliminate the long term memories associated …

Diagnosis Of Lchad/Tfp Deficiency In An At Risk Newborn Using Umbilical Cord Blood Acylcarnitine Analysis, Donna Raval, Kristina Cusmano-Ozog, Omar Ayyub, Callie Jenevein, Laura Kofman, Brendan Lanpher, Natalie Hauser, Debra Regier

Pathology Faculty Publications

Trifunctional protein deficiency/Long-chain hydroxyacyl-CoA dehydrogenase deficiency (LCHAD/TFP) deficiency is a disorder of fatty acid oxidation and ketogenesis. Severe neonatal lactic acidosis, cardiomyopathy, and hepatic dysfunction are caused by the accumulation of toxic long-chain acylcarnitines. The feasibility of umbilical cord blood use in screening for acylcarnitine analysis and free carnitine has been hypothesized but not reported in LCHAD/TFP neonates.

We present a 4 week old female who was at risk of inheriting LCHAD/TFP deficiency and was diagnosed at the time of delivery using umbilical cord blood. Umbilical cord blood was collected at delivery and sent for acylcarnitine analysis. Treatment was started …

The Descriptive Epidemiology Of Dsm-Iv Adult Adhd In The World Health Organization World Mental Health Surveys, John Fayyad, Nancy A. Sampson, Irving Hwang, Tomasz Adamowski, Sergio Aguilar-Gaxiola, Ali Al-Hamzawi, Laura H. S. G. Andrade, Guilherme Borges, Giovanni De Girolamo, Silvia Florescu, Oye Gureje, Josep Maria Haro, Chiyi Hu, Elie G. Karam, Sing Lee, Fernando Navarro-Mateu, Siobhan O'Neill, Beth-Ellen Pennell, Marina Piazza, José Posada-Villa, Margreet Ten Have, Yolanda Torres, Miguel Xavier, Alan M. Zaslavsky, Ronald C. Kessler

Clinical and Translational Science Institute

We previously reported on the cross-national epidemiology of ADHD from the first 10 countries in the WHO World Mental Health (WMH) Surveys. The current report expands those previous findings to the 20 nationally or regionally representative WMH surveys that have now collected data on adult ADHD. The Composite International Diagnostic Interview (CIDI) was administered to 26,744 respondents in these surveys in high-, upper-middle-, and low-/lower-middle-income countries (68.5% mean response rate). Current DSM-IV/CIDI adult ADHD prevalence averaged 2.8% across surveys and was higher in high (3.6%)- and upper-middle (3.0%)- than low-/lower-middle (1.4%)-income countries. Conditional prevalence of current ADHD averaged 57.0% among …

Association Between Statin Medications And Copd-Specific Outcomes: A Real-World Observational Study, Mayank Ajmera, Chan Shen, Usha Sambamoorthi

Clinical and Translational Science Institute

Background Disease-modifying drugs are not yet available for the management of chronic obstructive pulmonary disease (COPD). HMG-CoA reductase inhibitors (statins) have anti-inflammatory properties and are therefore being considered for use in the management of COPD. Objective Our objective was to examine the association between statin use and COPD-specific outcomes in a realworld setting. Methods This was a retrospective longitudinal dynamic cohort study that used Medicaid claims data from multiple years (2005–2008) to identify patients with newly diagnosed COPD. Statin therapy was determined from the prescription drug file using National Drug Codes (NDCs). COPD-specific outcomes such as hospitalizations and emergency room …

Imaging Thiol Redox Status In Murine Tumors In Vivo With Rapid-Scan Electron Paramagnetic Resonance, Boris Epel, Subramanian V. Sundramoorthy, Martyna Krzykawska-Serda, Matthew C. Maggio, Mark Tseytlin, Gareth R. Eaton, Sandra S. Eaton, Gerald M. Rosen, Joseph P. Y. Kao, Howard J. Halpern

Clinical and Translational Science Institute

Thiol redox status is an important physiologic parameter that affects the success or failure of cancer treatment. Rapid scan electron paramagnetic resonance (RS EPR) is a novel technique that has shown higher signal-to-noise ratio than conventional continuous-wave EPR in in vitro studies. Here we used RS EPR to acquire rapid three-dimensional images of the thiol redox status of tumors and normal tissues in living mice. This work presents, for the first time, in vivo RS EPR images of the kinetics of the reaction of 2H,15N-substituted disulfide-linked dinitroxide (PxSSPx) spin probe with intracellular glutathione. The cleavage rate is proportional to the …