Medicine and Health Sciences Commons^™

Contributions Of The Anterolateral Complex And The Anterolateral Ligament To Rotatory Knee Stability In The Setting Of Acl Injury: A Roundtable Discussion, Volker Musahl, Alan Getgood, Philippe Neyret, Steven Claes, Jeremy M. Burnham, Cecile Batailler, Bertrand Sonnery-Cottet, Andy Williams, Andrew Amis, Stefano Zaffagnini, Jón Karlsson

Bone and Joint Institute

© 2017, European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA). Persistent rotatory knee laxity is increasingly recognized as a common finding after anterior cruciate ligament (ACL) reconstruction. While the reasons behind rotator knee laxity are multifactorial, the impact of the anterolateral knee structures is significant. As such, substantial focus has been directed toward better understanding these structures, including their anatomy, biomechanics, in vivo function, injury patterns, and the ideal procedures with which to address any rotatory knee laxity that results from damage to these structures. However, the complexity of lateral knee anatomy, varying dissection techniques, differing specimen preparation methods, …

Sleep-Based Memory Processing Facilitates Grammatical Generalization: Evidence From Targeted Memory Reactivation., Laura J Batterink, Ken A Paller

Brain and Mind Institute Researchers' Publications

Generalization-the ability to abstract regularities from specific examples and apply them to novel instances-is an essential component of language acquisition. Generalization not only depends on exposure to input during wake, but may also improve offline during sleep. Here we examined whether targeted memory reactivation during sleep can influence grammatical generalization. Participants gradually acquired the grammatical rules of an artificial language through an interactive learning procedure. Then, phrases from the language (experimental group) or stimuli from an unrelated task (control group) were covertly presented during an afternoon nap. Compared to control participants, participants re-exposed to the language during sleep showed larger …

Alumni Journal - Volume 88, Number 1, Loma Linda University School Of Medicine

Alumni Journal, School of Medicine

Features
10 | 85 Years of the Alumni JOURNAL
14 | APC 2017: A Preview
18 | Interview: Brain Surgery to Global Surgery, Walter D. Johnson ’83
26 | Am I My Brother’s Keeper?

Departments
2 | Fron the Editor
3 | This and That
4 | From the President
6 | From the Dean
7 | The Student Fund
8 | School of Medicine News
38 | AIMS Report
40 | Book Review
42 | Alumni News
43 | Placement and Classified Ads
44 | In Memoriam
49 | What's Up Doc?

Extras
3 | New and Upgraded Perpetual …

Visual, Verbal, And Tactile Cues On Improving Gait In A 71-Year Old Male With Dementia Of The Lewy Bodies, Symone Carter, Jackie Crossen-Sills

St. Augustine, Spring 2017

The purpose of the case report is to demonstrate how visual, verbal, and tactile cues can improve gait in a patient with DLB.

Training Of Anticipatory Postural Adjustments In An 83-Year-Old Female With Severe Anxiety Post-Femoral Fracture: A Case Report, Chandler Witt, Anne H. Boddy

St. Augustine, Spring 2017

The purpose of this case report is to present the outcomes of using APA training exercises in conjunction with conventional physical therapy to improve gait independence, and movement anxiety in older adult patients post femoral fracture secondary to a fall.

Chain Reaction: Functional Strengthening For The Treatment Of Posterior Tibialis Tendinopathy In An Adolescent Athlete, Emily Terrell, John Layne

St. Augustine, Spring 2017

The purpose of this case report was to describe the successful addition of lower extremity kinetic chain functional strengthening to the standard of care for chronic PPT treatment.

You Down With Alter-G? Yeah, You Better Be!, Tom Phan, Anne H. Boddy

St. Augustine, Spring 2017

The purpose of this study was to investigate the effectiveness of free rehabilitation protocol utilizing an Alter-G treadmill system.

Don’T Let Me Fall: Implementing The Use Of Assistive Standing Device With Functional Task Specific Training Can Improve Safety Of Transfers In A 65 Y/O Woman With Primary Lateral Sclerosis: A Case Report, Megan Farr, Lindsay Perry

St. Augustine, Spring 2017

The purpose of this case report is to describe improvements of a novel functional training program in a patient diagnosed with PLS.

Upping The Ante!: Physical Therapist Management Of Femoral Anteversion, Kathryn R. Terrian, Matthew L. Daugherty

St. Augustine, Spring 2017

The purpose of this case report is to describe the outcomes following the rehabilitation of an 11-year-old female athlete with femoral anteversion utilizing Pilates based therapy in conjunction with traditional physical therapy.

Stem Cell Derived Osteoprogenitors And Their Role In Bone Repair Using Morphogenic Activators, George Washington Brownridge Iii, Sylvanna Islas, Angelina Miller, Warren Hoeffler

Student Research Posters

Bone constantly cycles through a dynamic process of breakdown and remodeling. Osteoblasts are the specialized mesenchymal stem cells that have a major role in bone formation and the remodeling process whereas their counterpart osteoclasts, handle bone resorption. Embryonic stem cells can be partially differentiated into Progenitor cells, and we worked with #18, a candidate for being an osteoprogenitor that has the potential to respond to morphogenic activators. In the case of bone remodeling, TGF-β 2, BMP-2 and an abundance of CA++ have been shown to be potential activators of differentiation into osteoblasts. Eight different trials were conducted with the cells …

Contact Point, Arthur A. Dugoni School Of Dentistry

Contact Point

No abstract provided.

Lost In Translation: Infusing Ignatian Pedagogy In On-Line Undergraduate Nursing Program, Jorgia Connor, Joanne Dunderdale, Tavis D. Jules, Patty Stapleton

Ignatian Pedagogy Educational Resources

No abstract provided.

Promoting Influenza Immunizations For Seniors In South Central Kentucky, M. Susan Jones, Matthew L. Hunt, Sujaya Thogaru

Nursing Faculty Publications

No abstract provided.

The Effect Of Gamification On Audiology Awareness Among Young Adults, Shenque Lester

Doctoral Dissertations

The profession of audiology is projecting a critical shortage of practicing professionals in the near future. Although there are many potential factors that are contributing to this problem, it is generally agreed that audiology as a profession is not readily identified as a career choice by undergraduate students, nor a recognizable healthcare field/service among the general public. Due to the increased instances of hearing loss in the general population as well as the aging of the population and need for audiological services, it is imperative to find an efficient means to improve the awareness of audiology as a potential career …

Use Of P53-Silenced Endothelial Progenitor Cells To Treat Ischemia In Diabetic Peripheral Vascular Disease., Nabanita Kundu, Cleyton C Domingues, Cyril Chou, Neeki Ahmadi, Sara Houston, D Joseph Jerry, Sabyasachi Sen

Medicine Faculty Publications

Background Peripheral vascular disease is a major diabetes mellitus‐related complication. In this study, we noted that expressions of proapoptotic p53 gene and its downstream cascade gene such as p21 are upregulated in hyperglycemia. Therefore, we investigated whether p53‐ and p21‐silenced endothelial progenitor cells (EPCs) were able to survive in hyperglycemic milieu, and whether transplantation of either p53 knockout (KO) or p21KO or p53‐ and p21‐silenced EPCs could improve collateral vessel formation and blood flow in diabetic vaso‐occlusive peripheral vascular disease mouse models.

Methods and Results We transplanted p53 and p21KO mouse EPCs (mEPCs) into streptozotocin–induced diabetic (type 1 diabetes mellitus …

Internal Medicine Resident Perspectives Regarding Broad-Spectrum Antibiotic Usage., Ann M Laake, Gayle Bernabe, James Peterson, Angelike P Liappis

Medicine Faculty Publications

Focus groups held with internal medicine residents discussed their perspectives regarding broad-spectrum antibiotic (BSA) usage. Residents knew of BSA-associated adverse events, but they did not associate such events with increased patient morbidity and mortality, and they were more likely to use BSA in situations with diagnostic uncertainty and sick patients.

Implications Of The Pegasus-Timi 54 Trial For Us Clinical Practice, S M. Bradley, G P. Hess, P Stewart, E J. Armstrong, Steven A. Farmer, J H. Wasfy, J A. Valle, A Sandhu, T M. Maddox

Medicine Faculty Publications

Objectives This study aims to determine the proportion of real-world patients with myocardial infarction (MI) who would have been eligible for the PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54) trial, to characterise their current use of P2Y₁₂ inhibitors and to explore the estimated costs and ischaemic event consequences of increasing P2Y₁₂ inhibitor use among these patients.

Methods In the US national ACTION Registry–GWTG (Acute Coronary Treatment and Intervention Outcomes Network Registry–Get With The Guidelines), we identified 273 328 patients …

Return To University After A Stroke: An Autoethnography, Rachel Sieber

Doctor of Occupational Therapy Capstone Projects

Background and Aims: Return to university presents a unique transition for the person with stroke who may demonstrate with impairments and may have difficulties while engaging in this change. This study will explore elements that comprise the needs and factors of the stroke survivor and supports or accommodations that may improve success of the student returning to university.

Methods: An autoethnography was used with narrative journals and poems dated June 2003 to October 2005, interviews with friends, family and professors and a literature review. Data analysis included an open-coding procedure to find themes from the journal entries, interviews and narrative …

Medicine + Health Magazine, Spring 2017, George Washington University, School Of Medicine And Health Sciences, Office Of Communications And Marketing

Medicine + Health Magazine

No abstract provided.

Gpr124 Is Essential For Blood-Brain Barrier Integrity In Central Nervous System Disease, Junlei Chang, Michael R. Mancuso, Carolina Maier, Xibin Liang, Kanako Yuki, Lu Yang, Jeffrey W. Kwong, Jing Wang, Varsha Rao, Mario Vallon, Cynthia Kosinski, J. J. Haijing Zhang, Amanda T. Mah, Lijun Xu, Le Li, Sharareh Gholamin, Teresa F. Reyes, Rui Li, Frank Kuhnert, Xiaoyuan Han, Jenny Yuan, Shin Heng Chiou, Ari D. Brettman, Lauren Daly, David C. Corney, Samuel H. Cheshier, Linda D. Shortliffe, Xiwei Wu, Michael Snyder

All Dugoni School of Dentistry Faculty Articles

Although blood-brain barrier (BBB) compromise is central to the etiology of diverse central nervous system (CNS) disorders, endothelial receptor proteins that control BBB function are poorly defined. The endothelial G-protein-coupled receptor (GPCR) Gpr124 has been reported to be required for normal forebrain angiogenesis and BBB function in mouse embryos, but the role of this receptor in adult animals is unknown. Here Gpr124 conditional knockout (CKO) in the endothelia of adult mice did not affect homeostatic BBB integrity, but resulted in BBB disruption and microvascular hemorrhage in mouse models of both ischemic stroke and glioblastoma, accompanied by reduced cerebrovascular canonical Wnt-β-catenin …

A Comparative Study On The Impact Evaluation Of World Vision’S Water, Sanitation And Hygiene Program In Malawi, Mozambique, And Zambia: Analyses Using Lives Saved Tool, Chulwoo Park, Armen Martirosyan, Erin A. Jones, Ashley Labat, Yvonne Tam, Emmanuel Opong

GW Research Days 2016 - 2020

Background

According to the World Health Organization, diarrheal disease is the second top killer of children under five years of age (U5), claiming around 760,000 young children’s lives every year, and 88% of diarrheal disease is attributed to unsafe water supply, inadequate sanitation and hygiene. The humanitarian aid organization, World Vision, launched community-based water, sanitation and hygiene (WASH) project in 76 Area Development Programs (ADPs) for 506,019 target U5 population across Southern Africa Region (SAR): Malawi, Mozambique and Zambia in 2010.

Objective

This study estimated the retrospective health impact of the project between 2010 and 2014 to measure how effectively …

Promotion Of New Diabetes Products In The District Of Columbia, Joy Eckert, Dilpan Sundaramoorthy, Alycia Hogenmiller

GW Research Days 2016 - 2020

Background: Growth in pharmaceutical expenditures for diabetes outpaced growth in diabetes prevalence. Prescribers accepting gifts and meals from pharmaceutical companies have been linked with higher prescription rates and costs[1]. Pharmaceutical marketing to these prescribers and patients often promotes newer, more expensive drugs, such as the GLP-1 analogues and SGL-2 inhibitors. These two drug classes are more expensive but no more effective than metformin,[2] the recommended first-line treatment for diabetes, and the oldest and cheapest available treatment. We investigated how cost of diabetes treatment was affected by marketing practices in the District of Columbia.

Methods: The AccessRx program …

What May Be Associated With Young Adult E-Cigarette Use? Examination Of Key Correlates, Diane J. Martinez, Monique M. Turner, Kathleen Roche, Kimberly Horn

GW Research Days 2016 - 2020

Given increasing rates of e-cigarette use among young adults, research is needed on the attitudes and beliefs that drive use among this age group. Tobacco control approaches used to prevent cigarette smoking may not work as effectively for preventing e-cigarette use. To address this research gap, the present study applied the Integrated Behavior Model (IBM) encompassing the affect heuristic theory to examine the individual-level determinants (i.e., attitude, perceived norm, personal agency, intention, and e-cigarette risk perception) of young adults' e-cigarette use. The 2013-2014 Population Assessment of Tobacco and Health (PATH) Study Wave 1 baseline adult dataset consisted of 9,112 young …

Anatomical Knowledge Retention In Changing Curricula, Alexa Lean, Juliet Lee, Ellen Goldman, Gisela Butera, Kirsten Brown, Rosalyn Jurjus

GW Research Days 2016 - 2020

Traditionally anatomy is one of the first subjects taught in medical school. Practicing physicians have commented on medical students’ poor anatomical knowledge in surgically oriented clerkships. Literature also shows that correlating clinical and anatomical sciences throughout early medical education may improve anatomical knowledge retention. With major medical school curricular changes happening across the nation, more quantitative data confirming this correlation is needed.

The medical curriculum at the George Washington University School of Medicine recently underwent reorganization, transforming an earlier discipline-based curriculum to that of an integrated system-based one. In order to determine whether reorganization has an effect on anatomical knowledge …

Emergency Department Approach To Electrical Toothbrush Associated Hand Injury, A Unique Case Of Non-Oropharyngeal Injury., Hannah Robinson, Neal Sikka, Chimere Little, Ali Pourmand

GW Research Days 2016 - 2020

Puncture wounds are common injuries treated in the emergency department (ED). Prior studies have shown that toothbrushes are common reservoirs for oral flora, especially in regions near the head of the toothbrush near the bristles. ED providers must be aware of the danger associated with bacterial contamination of the associated wound and should be familiar with different pathogens and options for treatment. We present a unique case of a 30-year-old male with non-intraoral injury who presented to the ED after puncturing his left palm with the metal post of an electric toothbrush.

A Review Of Pain Control In Pediatric Cardiac Bypass Surgery, Pranathi Ari, Andrew T. Waberski, Nina Deutsch

GW Research Days 2016 - 2020

Background: Children undergoing cardiac surgery with cardiopulmonary bypass receive high dose opioids for analgesia and to reduce the neurohormonal stress response. While opioids have excellent pharmacodynamics profiles adverse effects include: respiratory depression, bradycardia, nausea, vomiting, and tolerance. Additionally, opioids with short half-lives like fentanyl require several boluses to be administered during surgery causing fluctuating levels analgesia. Several strategies to advance pain control incorporate regional and neuraxial anesthetic techniques, however anticoagulation preclude its routine use. Alternatively using opioids with longer half-lives for analgesia may improve pain control and reduce adverse effects.

Objective: The objective of this study is to quantify postoperative …

Medical Resource Utilization Of Outpatient Care For Children With Neurofibromatosis Type 1, Rabia Idrees, Michael Fisher, Rachel Hachen, Brian Callaghan, Robert A. Avery

GW Research Days 2016 - 2020

Background:

Neurofibromatosis Type 1 (NF1) is an autosomal dominant syndrome with manifestations affecting the central nervous system, musculoskeletal system, peripheral nervous system, and cognitive/behavioral functions. Many of these manifestations persist throughout life and require medical/surgical interventions.

The resource utilization and economic burden of caring for children with NF1 is unknown. Prior research has inherent selection bias and does not accurately reflect the incidence/resource utilization of morbidities. In order to identify which disease manifestations are in the most need of improved clinical algorithms and novel therapeutics, the frequency/type of resources utilized (i.e., diagnostic imaging and specialty visits) must be determined.

The …

Stakeholders' Perceptions Of A Hospital Based Emergency Medicine Education & Training Program: A System Change, Kate Douglass, Jay Pandya, Michael Brennan, Kyle Yoder, Janice Blanchard, Natasha Powell, Zohray Talib

GW Research Days 2016 - 2020

Background: Emergency Medicine (EM) is a new and developing specialty around the world. In India, one model for capacity building has been the development of partnerships between US academic institutions and private healthcare institutions for implementing post-graduate education and training in EM. Initiated in 2007, programs have grown both in number and scope and have continued to attract new students and partner institutions. This study was undertaken to better understand the impact of EM training programs on hospital systems.

Methods: A mixed-methods evaluation was undertaken at 5 program sites across India in the summer of 2016. Two researchers conducted onsite …

Removing Barriers To Care For The Underserved: Provider And Patient Perception Of Direct To Consumer Telemedicine, Robert M. Grell, Rachel Hatcliffe, Sean M. Gillen, Craig Sable, Vanessa Grant, Matthew Ledda, Mary Fuska, Shireen Atabaki

GW Research Days 2016 - 2020

Purpose of Study: Lack of access to pediatric subspecialty care is a major barrier to pediatric health for underserved populations in the Washington DC, Virginia and Maryland area. Lack of access to transportation, long office wait times, and missed school and work are barriers that prevent access to subspecialty care. Direct to consumer (DTC) telemedicine provides this service to our underserved population by bringing care into their own home through use of computers, tablets, and smart phones.

Methods Used: Structured interviews of parents and providers were performed prior to implementation of a subspecialty DTC telemedicine program for underserved children in …

Fungus Amungus -- A Common Disease State That Is Commonly Missed: A Survey Based Study, Ramsin Yadgar, Adam Friedman, Neal Bhatia

GW Research Days 2016 - 2020

Background: Dermatophyte infections involving the skin, hair, or nails affect an estimated 25% of the world's population, and accounted for 51 million outpatient visits over a ten-year period (1995-2004) in the United States alone. Dermatomycosis is routinely managed by dermatologists, though given the diversity of clinical presentations, is sometimes misdiagnosed, which can result in inappropriate therapy, worsening of symptoms, and even result in additional skin and soft tissue infections.

Methods: An interactive survey of board-certified dermatologists was conducted at the 2016 Orlando Dermatology Aesthetic & Clinical Conference, during a seminar on superficial mycotic infections. The structure of the survey entailed …