Medicine and Health Sciences Commons^™

การระบุเพศ บทบาททางเพศ และอัตลักษณ์ทางเพศในผู้ป่วยอวัยวะเพศกำกวมที่เข้ารักษาในโรงพยาบาลจุฬาลงกรณ์, พันตรี เกิดโชค, ปริชวัน จันทร์ศิริ, ธนินี สหกิจรุ่งเรือง

Chulalongkorn Medical Journal

เหตุผลของการทำวิจัย : ผู้ป่วยที่มีอวัยวะเพศกำกวม มักประสบความลำบากในการระบุเพศมีรายงานว่าผู้ป่วยอาจมีบทบาททางเพศ และอัตลักษณ์ทางเพศที่เบี่ยงเบน แต่การศึกษาเรื่องพัฒนาการทางเพศในผู้ป่วยกลุ่มนี้ยังขาดแคลนทั้งในประเทศไทยและต่างประเทศวัตถุประสงค์ : เพื่อศึกษาการระบุเพศ อัตลักษณ์ทางเพศ และบทบาททางเพศในผู้ป่วยอวัยวะเพศกำกวมวิธีการศึกษา : ศึกษาในกลุ่มผู้ป่วยที่มีภาวะอวัยวะเพศกำกวม อายุระหว่าง 3 - 18 ปีจำนวน 30 รายและผู้ปกครอง ที่แผนกผู้ป่วยนอกต่อมไร้ท่อฝ่ายกุมารเวชศาสตร์ โรงพยาบาลจุฬาลงกรณ์ ระหว่างเดือนมกราคมถึงเดือนพฤษภาคม พ.ศ. 2559 โดยใช้การสัมภาษณ์เชิงลึกโดยใช้แนวคำถาม ที่ได้จากการทบทวนวรรณกรรมเกี่ยวกับเรื่อง อัตลักษณ์ทางเพศ บทบาททางเพศ ร่วมกับการรวบรวมข้อมูลจากเวชระเบียนผู้ป่วย เป็นการศึกษาเชิงคุณภาพ และทำการวิเคราะห์แบบโคไลซี่ และcontent analysisผลการศึกษา : พบผู้ป่วยโรค 46XX, disorders of sexual developments (DSD)21 ราย, 46XY, DSD 8 ราย 45X,46XY DSD 1 รายมีผู้ป่วย 9 รายที่เคยได้รับการประเมินทางจิตวิทยา มีผู้ป่วยที่ไม่ได้เข้ารับการรักษาตั้งแต่แรกเกิด 12 ราย มีผู้ป่วยที่ได้รับการระบุเพศแรกเกิดเป็นเพศหญิง20 ราย เพศชาย 10 ราย และมีผู้ป่วยได้รับการระบุเพศใหม่โดยแพทย์5 ราย ผู้ป่วยขอเปลี่ยนเพศเอง 2 ราย พบรูปแบบของบทบาททางเพศในผู้ป่วย 46XX, DSD ด้านทรงผม การแต่งตัว และกลุ่มเพื่อน เป็นแบบหญิง ต่างจากบทบาทด้าน กิจกรรม การเล่นหรือของเล่นที่เป็นแบบชายหรือแบบผสม ในขณะที่บทบาททางเพศของผู้ป่วย 46XY, DSDส่วนใหญ่เป็นแบบชาย พบผู้ป่วยที่มีอัตลักษณ์ทางเพศหญิง 17 ราย,ชาย 9 ราย, ไม่แน่ใจ 1 ราย และยังแยกแยะเพศไม่ได้ 3 ราย โดยผู้ป่วย46XX,DSD ที่มีอัตลักษณ์ทางเพศหญิง 4 ราย แสดงความต้องการจะเป็นอีกเพศหนึ่ง.สรุป : บทบาททางเพศส่วนใหญ่สอดคล้องกับโครโมเซมเพศ ยกเว้นบทบาททางเพศด้านกิจกรรม การเล่นหรือของเล่นในผู้ป่วยอวัยวะเพศกำกวมที่มีโครโมโซมเพศหญิงที่เป็นบทบาทแบบชาย ในขณะที่พบอัตลักษณ์ทางเพศของผู้ป่วยบางรายไม่ตรงกับโครโมโซมเพศ อนึ่งผู้ป่วยจำนวนมากไม่ได้รับการรักษาตั้งแต่แรกเกิด …

Chronic Myeloid Leukemia After Chemotherapy For Adenocarcinoma Of The Rectum: A Case Report, Likhasit Sanglutong, Somchai Insiripong

Chulalongkorn Medical Journal

Chronic myeloid leukemia (CML) after chemotherapy for any primary malignancy has been occasionally reported. Herein we reported one definite case of CML who was diagnosed after the treatment of adenocarcinoma of the rectum. A 79-year-old Thai man was diagnosed with moderately differentiated adenocarcinoma of the rectum invading the urinary bladder. And he was treated with rectal resection and lymph nodes excision, followed by 5-fluoro-uracil and leucovorin therapy. He remained in complete remission for 1.5 years until he suddenly passedthe hematochezia for one day and very high white blood cell and platelet counts without weight loss. The physical examination revealed no …

Body Size Perception In Thai School-Aged Children, Chansuda Bongsebandhu-Phubhakdi, Orapa Suteerojntrakool, Therdpong Tempark

Chulalongkorn Medical Journal

Background : Body size perception is the basic of body image that usually be developed during early childhood. Overestimation of children and/or their parents may lead further negative body image, whereas underestimation may cause overlooked obesity problems.Objectives : To investigate the accuracy of body size perception among Thai school-aged children and the correlation between children’s and their parents’ estimation.Methods : In 2015, a cross-sectional study was conducted in a primary school in central Bangkok. Anthropometric indices were measured. Perceived body sizes of children was assessed by the children and their parents using visual image scale (Children Body Scale: CBIS).Results : …

Differences In Interlimb Performance During A Repetitive Step Test In Older Adults, Harold L. Merriman, Kurt Jackson, Wesley Horn, Jake Jones, Evan Price, Jill Spicer

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Each year, one out of three adults (younger than 65 years old) experiences a fall, resulting in fractures, head injuries, and even death. Falling is the leading cause of death from an injury and causes the greatest number of nonfatal injuries and hospital admissions for trauma. Since balance and muscle performance decrease as one ages, it is vitally important to assess these factors as part of a comprehensive strategy to monitor and predict fall risk. Previous data analysis of the Repetitive Step Test (RST) has shown that there is a correlation between subject performance and fall risk between non-fallers and …

Instrumented Measures Of Gait And Mobility Are Not Correlated With A History Of Falls Or Balance Confidence In Individuals With Multiple Sclerosis, Brandi Elking, Courtney Hasson, Emily Sanders, Kelsey Schlater

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Individuals diagnosed with Multiple Sclerosis (MS) often have an increased risk of falling. Additionally, many also have a fear of falling that all can affect balance confidence. Recent advancements in wearable sensor technology have made it possible to assess certain aspects of gait and balance in the clinical setting that were not possible previously. The information collected by sensors may be useful for identifying specific factors that contribute to falls and balance confidence in those with MS which in turn could help enhance treatment approaches.

An Item-To-Total Analysis Of The Foot Posture Index, Amanda Pallija, Brian Bohman, Paige Prenger, Emely Richardson, Joaquin Barrios

University of Dayton Doctor of Physical Therapy Annual Research Symposium

The Foot Posture Index (FPI) is a screening tool used by clinicians to assess if the foot is pronated, neutral or supinated. It is intended to quantify foot position by assigning positive values to pronated attributes and negative values to supinated attributes. Three hindfoot and 3 forefoot attributes are scored. Although the FPI is valid and reliable, individual component scores may skew the composite score. Therefore, there lies a need to investigate the internal consistency of the FPI.

A Comparison Of Arch Height Index Measures Between Collegiate Basketball And National Basketball Association Players, Philip Anloague, N Hess, L Barhorst, G Hock, A Iannarino, A Kelly, C Williams

University of Dayton Doctor of Physical Therapy Annual Research Symposium

The rate of game related basketball injuries is 2xs greater in professionals than collegiate players and the most common injuries occur in the lower extremity. Arch mechanics are often cited as a related factor and the Arch Height Index Measurement System (AHIMS) is a reliable and valid system for quantifying mobility. However, normative or comparative values for basketball athletes have not been reported.

Teaching Joint Mobilizations In Physical Therapist Assistant Programs: Implications For Instruction And Policy, Renae H. Gorman

Student Dissertations

This research answers the question: Are physical therapist assistant programs teaching the manual therapy skill of joint mobilizations? This study also gathers information regarding how the joint mobilization techniques are being instructed and assessed within the Physical Therapist Assistant programs. This information could serve as the foundation for future research regarding developing instructional and evaluation strategies for manual therapy skills. The findings of this study may also affect the physical therapist assistants in clinical performance of manual therapy. The findings are pertinent due to conflicting statements by the professional organizations and the accrediting agency of physical therapist assistant educational programs. …

Cross-Cultural Investigation Of Birth Experience : A Comparison Between Mexico And The United States., Alice J Darling

College of Arts & Sciences Senior Theses

This study investigates the maternal birth experience through a cross-cultural lens. While the field of medical anthropology has researched birth practices of many cultures, few cross-cultural studies have been performed and no recent studies have suggested a transition in birthing. Ethnographic interviews with women and practitioners in Yucatán, Mexico and with women in Kentucky, United States allowed for a better understanding of the respective birthing environments. Grounded theory was then employed to develop a birth transition theory explaining changes occurring when society transitions from traditional birth practitioners to allopathic birth practitioners. The themes of knowledge, expectation and power were isolated …

Synthesis Of A Nanoscale Gold-Coated, Thermoresponsive Molecular Release System., Ryan C. Weegens

College of Arts & Sciences Senior Theses

The work presented here was performed in conjunction with an experimental group in order to prove the concept that an alternating magnetic field (AMF) could be used to induce an intramolecular cyclization to effect payload release. The system studied here consisted of a fluorophore tethered to gold-coated iron oxide nanoparticles (Fe₃O₄ NPs) via an organic linker consisting of 2 key elements: a carbonate (electrophile) and an amine (nucleophile). Connected to the carbonate was the fluorophore, anthracene, which was attached to the organic linker system by means of an oxime ether linkage. This thesis work served as the …

High School Student Concussion Recovery Program: Teacher Involvement In Student Academic Transitions To Classroom And To Sports, Brittany Diego

Dissertations, Masters Theses, Capstones, and Culminating Projects

Many symptoms of concussions can substantially interfere with the cognitive abilities, and skills students use in school. Although students may have similar symptoms, they experience concussions differently. Students returning to the classroom from a concussion often have different needs and abilities.

Research shows that a formal, individualized protocol to treat suspected concussions, both academically and physically, is vital to the successful recovery of each student. Much research is available on concussions for professional athletes, specifically related to recovery and returning to their sport. However, there is little research about high school students regarding concussions. Concussion recovery programs for high school …

Clinician-Parent Discussions About Influenza Vaccination Of Children And Their Association With Vaccine Acceptance, Annika M. Hofstetter, Jeffrey D. Robinson, Katherine Lepere, Morgan Cunningham, Nicole Etsekson, Douglas J. Opel

Communication Faculty Publications and Presentations

Objective: To examine how clinicians communicate with parents about influenza vaccination and the effect of these communication behaviors on parental vaccine decision-making.

Study Design: We performed a secondary analysis of data obtained from a cross-sectional observational study in which health supervision visits between pediatric clinicians and English-speaking parents of young children were videotaped. Eligible visits occurred during the 2011-2012 and 2013-2014 influenza seasons, included children ≥ 6 months, and contained an influenza vaccine discussion. A coding scheme of 10 communication behaviors was developed and applied to each visit. Associations between clinician communication behaviors and parental verbal vaccine acceptance …

Associations Among Meaning Of Illness, Quality Of Life, Symptom Burden And Depression In Patients With Leptomeningeal Metastasis, Julie Walker

Dissertations and Theses (Open Access)

Background Patients with leptomeningeal metastasis (LM) have symptoms related to disease within the neuroaxis, cancer sites outside the neuroaxis and treatment toxicities. Furthermore, the meaning ascribed to advanced cancer, such as LM, may impact the perceived severity, frequency and distress of symptoms as well as quality of life (QoL) and depression. Our aim was to explore and describe relationships among meaning of illness (MoI), depression, QoL and symptom burden in LM patients and to explore whether adding spine-related items from the MD Anderson Symptom Inventory-Spine (MDASI-SP) to the MDASI-Brain Tumor (BT) enhanced understanding of symptom burden in this population.

Methods …

Effective Psychodrama Supervision: A Grounded Theory Study On Senior Supervisors' Perspectives, Simone Levy Tabib

Expressive Therapies Dissertations

The overarching purpose of this two-phase study was to gain understanding about and insight into the practice of effective psychodrama supervision as a specialty field. The study explored senior supervisors’ perspectives on their roles as in-class group supervisors in psychodrama graduate school programs in Israel. Grounded theory (GT) methods of data collection and analysis were aimed at learning about participants’ professional approaches, and practice- based experiences. Study 1 involved face-to-face in-depth interviews conducted with open-ended core questions. The interviews explored how six expert participants approached the practice of PD supervision and the reasons behind their approaches. The findings shed light …

The Effects Of Yoga On Balance, Strength, Flexibility, And Mindfulness In Typical Children Ages 4-9 Years, Betsy Donahoe Fillmore, Mary I. Fisher, Katie Lunsford, Justin Master, Sarahanne Pelkey, Emily Puthoff, Kristen Schulte, Brittany Snider, Jordan Villanueva

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Yoga improves a variety of impairments in typical pediatric populations: cardiovascular, neuromuscular, musculoskeletal, and pulmonary conditions, balance, strength, and flexibility. Yoga improves mindfulness in adult populations, and emerging evidence shows a similar effect among pediatric populations.

Functional Performance Of Older Adults With Dementia Participating In Adult Day Service Programs, Kurt Jackson, Kimberly Edginton-Bigelow, Elizabeth Cox, Allison Gaier, Hannah Geyer, Ethan Grant, Kayla Storey

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Individuals with dementia are at a high risk of functional decline and falling. The aim of this study was to investigate the possible relationship between cognition and functional performance in older adults with dementia participating in Goodwill Easter Seals adult day service programs. This data may be helpful in understanding how cognition may impact functional performance and fall risk.

Quality Assurance Guidelines For Superficial Hyperthermia Clinical Trials : Ii. Technical Requirements For Heating Devices., Hana Dobšíček Trefná, Johannes Crezee, Manfred Schmidt, Dietmar Marder, Ulf Lamprecht, Michael Ehmann, Jacek Nadobny, Josefin Hartmann, Nicolleta Lomax, Sultan Abdel-Rahman, Sergio Curto, Akke Bakker, Mark D. Hurwitz, Chris J. Diederich, Paul R. Stauffer, Gerard C. Van Rhoon

Department of Radiation Oncology Faculty Papers

Quality assurance (QA) guidelines are essential to provide uniform execution of clinical trials with uniform quality hyperthermia treatments. This document outlines the requirements for appropriate QA of all current superficial heating equipment including electromagnetic (radiative and capacitive), ultrasound, and infrared heating techniques. Detailed instructions are provided how to characterize and document the performance of these hyperthermia applicators in order to apply reproducible hyperthermia treatments of uniform high quality. Earlier documents used specific absorption rate (SAR) to define and characterize applicator performance. In these QA guidelines, temperature rise is the leading parameter for characterization of applicator performance. The intention of this …

Alcohol Related Rural Emergency Department Use: A Treatment Opportunity, Ezekiel Sanders

Doctor of Psychology (PsyD)

The negative impact of alcohol on an individual’s social, psychological, and physiological health is well known. Despite this knowledge, it remains a prevalent problem in our society. Residents of rural communities encounter a wide range of risk factors including poverty, unemployment, and limited access to healthcare. These factors can influence both the prevalence and treatment for alcohol use disorders. With limited access to medical resources, the Emergency Department (ED) can become the default provider for problems related to alcohol use. The reported prevalence of alcohol-related problems in the ED varies widely from an estimated 2% to 40% of all visits. …

The Effect Of Wideband And Narrowband Noise On The Olivocochlear Bundle And The Cochlear Microphonic, Catherine Nicole Palmietto

Graduate Theses/Dissertations

In humans, activation of the olivocochlear bundle (OCB) can have a suppression or enhancement effect on cochlear processes. This phenomenon was studied via OCB activation effects on otoacoustic emissions (OAEs). However, it has been suggested that cochlear microphonics (CMs) can provide better, more detailed information regarding OCB function. In the present study, 22 normal hearing female subjects between the ages of 18-30 were recruited and the OCB was examined via the recording of CMs under changes in three conditions: OCB activating noise, stimulus polarity and stimulus frequency. Specifically, the present study examines the effects of activating wideband noise and narrowband …

Borrelia Burgdorferi-Specific Iga In Lyme Disease, Christina D'Arco, Raymond Dattwyler, Paul Arnaboldi

NYMC Faculty Publications

The laboratory diagnosis of Lyme disease is currently dependent on the detection of IgM and IgG antibodies against Borrelia burgdorferi, the causative agent of the disease. The significance of serum IgA against B. burgdorferi remains unclear. The production of intrathecal IgA has been noted in patients with the late Lyme disease manifestation, neuroborreliosis, but production of antigen-specific IgA during early disease has not been evaluated. In the current study, we assessed serum IgA binding to the B. burgdorferi peptide antigens, C6, the target of the FDA-cleared C6 EIA, and FlaB(211-223)-modVlsE(275-291), a peptide containing a Borrelia flagellin epitope linked to a …

Evidence Of Strain Structure In Plasmodium Falciparum Var Gene Repertoires In Children From Gabon, West Africa, K Day, Y Artzy-Randrup, K Tiedje, V Rougeron, Donald S. Chen, T Rask, M Rorick, F Migot-Nabias, P Deloron, A Luty, M Pascual

NYMC Faculty Publications

Existing theory on competition for hosts between pathogen strains has proposed that immune selection can lead to the maintenance of strain structure consisting of discrete, weakly overlapping antigenic repertoires. This prediction of strain theory has conceptual overlap with fundamental ideas in ecology on niche partitioning and limiting similarity between coexisting species in an ecosystem, which oppose the hypothesis of neutral coexistence. For Plasmodium falciparum, strain theory has been specifically proposed in relation to the major surface antigen of the blood stage, known as PfEMP1 and encoded by the multicopy multigene family known as the var genes. Deep sampling of the …

Treatment Of Hypertensive Emergencies, Wilbert S. Aronow

NYMC Faculty Publications

No abstract provided.

Thrombotic Microangiopathy Associated With Synthetic Cannabinoid Receptor Agonists, Michael Karass, Savneek Chugh, Gabriela Andries, A Mamorska-Dyga, John C. Nelson, Praveen Chander

NYMC Faculty Publications

Marijuana is one of the most commonly used recreational drugs in the United States. As marijuana is illegal in the majority of countries, the use of readily available and unregulated synthetic cannabinoids (SCBs) has increased. Little is known about the potential adverse effects of SCBs especially in regards to their nephrotoxicity. Case reports of acute kidney injury (AKI) from acute tubular injury secondary to their use have been reported. However, the exact pathology, mechanism, and extent of renal injury remain unknown. We report the first case of biopsy proven thrombotic microangiopathy (TMA) associated with SCBs resulting in AKI. The patient …

Improved Survival After Acute Graft-Versus-Host Disease Diagnosis In The Modern Era, H Khoury, T Wang, Michael T. Hemmer, D Couriel, A Alousi, Mitchell Cairo, J Pidala

NYMC Faculty Publications

Acute graft-versus-host disease remains a major threat to a successful outcome after allogeneic hematopoietic cell transplantation. While improvements in treatment and supportive care have occurred, it is unknown whether these advances have resulted in improved outcome specifically among those diagnosed with acute graft-versus-host disease. We examined outcome following diagnosis of grade II-IV acute graft-versus-host disease according to time period, and explored effects according to original graft-versus-host disease prophylaxis regimen and maximum overall grade of acute graft-versus-host disease. Between 1999 and 2012, 2,905 patients with acute myeloid leukemia (56%), acute lymphoblastic …

Pulmonary Embolism In Transit, Anna Koulova, Ramin Malekan, Wilbert Aronow, Howard Cooper

NYMC Faculty Publications

A 65-year-old woman with recently diagnosed ovarian cancer presented with near syncope, tachypnea, and hypoxia. Transthoracic echocardiography revealed a dilated and hypokinetic right ventricle and a large, mobile mass in the right atrium prolapsing across the tricuspid valve. She was diagnosed with pulmonary embolism in transit and emergent embolectomy was recommended.

Differences In Speb Protease Activity Among Group A Streptococci Associated With Superficial, Invasive, And Autoimmune Disease, A Ly, J Noto, O Walwyn, R Tanz, S Shulman, W Kabat, Debra Bessen

NYMC Faculty Publications

The secreted cysteine proteinase SpeB is an important virulence factor of group A streptococci (GAS), whereby SpeB activity varies widely among strains. To establish the degree to which SpeB activity correlates with disease, GAS organisms were recovered from patients with pharyngitis, impetigo, invasive disease or acute rheumatic fever (ARF), and selected for analysis using rigorous sampling criteria; >300 GAS isolates were tested for SpeB activity by casein digestion assays, and each GAS isolate was scored as a SpeB-producer or non-producer. Highly significant statistical differences (p < 0.01) in SpeB production are observed between GAS recovered from patients with ARF (41.5% SpeB-non-producers) compared to pharyngitis (20.5%), invasive disease (16.7%), and impetigo (5.5%). SpeB activity differences between pharyngitis and impetigo isolates are also significant, whereas pharyngitis versus invasive isolates show no significant difference. The disproportionately greater number of SpeB-non-producers among ARF-associated isolates may indicate an altered transcriptional program for many rheumatogenic strains and/or a protective role for SpeB in GAS-triggered autoimmunity.

Decreasing Cerebral Oxygen Consumption During Upright Tilt In Vasovagal Syncope, Marvin Medow, M Kothari, A Goetz, M O'Donnell-Smith, C Terilli, Julian Stewart

NYMC Faculty Publications

We measured changes in transcranial Doppler ultrasound (TCD) and near infrared spectroscopy (NIRS) during 70 degrees upright tilt in patients with recurrent vasovagal syncope (VVS, N = 20), postural tachycardia syndrome (POTS, N = 20), and healthy controls (N = 12) aged 15-27 years old. VVS was included if they fainted during testing within 5-15 min of upright tilt. We combined TCD and NIRS to obtain estimates of percent change in the cerebral metabolic rate of oxygen consumption (CMRO2), cerebral blood flow velocity (CBFv), and oxygen extraction fraction (OEF). Over the course of 10 min of upright tilt, CBFv decreased …

Plastic Injection Moulding Machines With Auxiliary Equipment: Safety During Maintenance And Production Interventions, Yuvin Chinniah, Sabrina Jocelyn, Barthélemy Aucourt, Réal Bourbonnière

Rapports de recherche scientifique

Les risques liés à l’interaction entre les presses à injection de plastique et leurs équipements périphériques (ex. : robots, convoyeurs) sont peu connus des gens du milieu et ces risques peuvent mener à des accidents du travail parfois mortels. Cette activité de recherche vise à étudier la sécurité des travailleurs sur des presses à injection de plastique horizontales ayant des équipements périphériques. Elle a pour objectif d’évaluer la sécurité des intervenants dans la zone du moule de ce type de presse, en faisant une identification des risques et une analyse des moyens de réduction de risques pour les tâches …

Effects On Breathing Of Agonists To Μ-Opioid Or GabaA Receptors Dialyzed Into The Ventral Respiratory Column Of Awake And Sleeping Goats, Thomas M. Langer Iii, Suzanne E. Neumueller, Emma Crumley, Nicholas J. Burgraff, Sawan Talwar, Matthew R. Hodges, Lawrence Pan, Hubert V. Forster

Physical Therapy Faculty Research and Publications

Pulmonary ventilation (V̇_I) in awake and sleeping goats does not change when antagonists to several excitatory G protein-coupled receptors are dialyzed unilaterally into the ventral respiratory column (VRC). Concomitant changes in excitatory neuromodulators in the effluent mock cerebral spinal fluid (mCSF) suggest neuromodulatory compensation. Herein, we studied neuromodulatory compensation during dialysis of agonists to inhibitory G protein-coupled or ionotropic receptors into the VRC. Microtubules were implanted into the VRC of goats for dialysis of mCSF mixed with agonists to either μ-opioid (DAMGO) or GABA_A (muscimol) receptors. We found: (1) V̇_I decreased during unilateral but increased during …

The Transcriptional Regulation Of The Human Angiotensinogen Gene After High-Fat Diet Is Haplotype-Dependent: Novel Insights Into The Gene-Regulatory Networks And Implications For Human Hypertension, A Rana, S Jain, N Puri, M Kaw, N Sirianni, D Eren, Brahma Mopidevi, Anand Kumar

NYMC Faculty Publications

Single nucleotide polymorphisms (SNPs) in the human angiotensinogen (hAGT) gene may modulate its transcription and affect the regulation of blood pressure via activation of the renin-angiotensin aldosterone system (RAAS). In this regard, we have identified polymorphisms in the 2.5 Kb promoter of the hAGT gene that form two haplotype (Hap) blocks: -6A/G (-1670A/G, -1562C/T, -1561T/C) and -217A/G (-532T/C, -793A/G, -1074T/C & -1178G/A). hAGT gene with Hap -6A/-217A (Hap I) is associated with increased blood pressure whereas, Hap -6G/-217G (Hap II) is associated with normal blood pressure in human subjects. Since RAAS over activity contributes to hypertension in obesity, we have …