Medicine and Health Sciences Commons^™

Functional Characterization Of A Multi-Cancer Risk Locus On Chr5p15.33 Reveals Regulation Of Tert By Znf148, Jun Fang, Jinping Jia, Matthew Makowski, Mai Xu, Zhaoming Wang, Tongwu Zhang, Jason W. Hoskins, Jiyeon Choi, Younghun Han, Mingfeng Zhang, Janelle Thomas, Michael Kovacs, Irene Collins, Marta Dzyadyk, Abbey Thompson, Maura O'Neill, Sudipto Das, Qi Lan, Roelof Koster, Panscan Consortium, Tricl Consortium, Genomel Consortium, Rachael S. Stolzenberg-Solomon, Peter Kraft, Brian M. Wolpin, Pascal W.T.C Jansen, Sara Olson, Katherine A. Mcglynn, Peter A. Kanetsky, Nilanjan Chatterjee, Jennifer H. Barrett, Alison M. Dunning, John C. Taylor, Julia A. Newton-Bishop, D. Timothy Bishop, Thorkell Andresson, Gloria M. Peterson, Christopher I. Amos

Dartmouth Scholarship

Genome wide association studies (GWAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33. Here, we show that fine-mapping of pancreatic and testicular cancer GWAS within one of these loci (Region 2 in CLPTM1L ) focuses the signal to nine highly correlated SNPs. Of these, rs36115365-C associated with increased pancreatic and testicular but decreased lung cancer and melanoma risk, and exhibited preferred protein-binding and enhanced regulatory activity. Transcriptional gene silencing of this regulatory element repressed TERT expression in an allele-specific manner. Proteomic analysis identifies allele-preferred binding of Zinc finger protein 148 (ZNF148) to rs36115365- C, further supported by binding of …

Implementation Of A Standardized Handoff During Transition Of Care From The Emergency Department To The Intensive Care Unit, Melinda Abbring

Evidence-Based Practice Project Reports

Patient safety and nursing communication are crucial to the nursing handoff during transition of care from the emergency department (ED) to the intensive care unit (ICU). The Institute of Medicine published To Err is Human: Building a Safer Health System (1999) and Crossing the Quality Chasm (2001) highlighting ED handoffs as a safety measure. In 2006, the Joint Commission recognized handoffs with the National Patient Safety Goal 2E. The purpose of this evidence-based practice project was to determine if implementation of a standardized handoff would improve nursing communication and patient safety during transition of care from the ED to the …

Pediatric Hematology/Oncology Outpatient Care: The Effect Of A Standardized Collaborative Medication Reconciliation Process, Traci R. Pulliam

Evidence-Based Practice Project Reports

Pediatric patients are at an increased risk for medication errors and can benefit from processes that facilitate and promote medication safety (Stone et al., 2010). Medication reconciliation (Med Rec) is a valuable tool in improving patients’ medication safety and reducing adverse drug events (The Joint Commission, 2015). The purpose of this evidence-based practice (EBP) project was to improve the accuracy of the Med Rec process in a Midwestern pediatric hematology/oncology outpatient clinic by developing, promoting, and evaluating a standardized, collaborative Med Rec process. The Stetler EBP model guided the implementation of the intervention, with the goal of integrating current evidence …

The Caffeine Consumption Habits, Sleep Quality, Sleep Quantity, And Perceived Stress Of Clinical Nurses, Mykin R. Higbee

Nursing Theses and Dissertations

Caffeine is the most widely consumed psychoactive substance worldwide. Energy drinks are a relatively new beverage type that contain three to five times more caffeine than regular sodas. In several workplace settings, energy drinks have become popular as individuals chose to consume these beverages in an attempt to combat fatigue, deal with stress, and boost energy. There is no information regarding the energy drink and caffeine consumption habits of nurses working in the clinical setting. Clinical nurses provide the majority of patient care in the health care setting. Nursing is a mentally and physically demanding profession due to heavy patient …

Creating A New Education Paradigm To Prepare Nurses For The 21st Century, Mary Bouchaud, Denise Brown, Beth Ann Swan

College of Nursing Faculty Papers & Presentations

Nurse educators are accountable to keep baccalaureate education responsive to the ever changing healthcare delivery environment. The changing context of healthcare delivery requires focusing on population health and social determinants, providing interprofessional, team-based care, advancing innovation, and preparing practice ready baccalaureate nursing graduates. To be practice ready, nursing graduates must be agile and think and reason on their feet due to increasing care complexity beyond the hospital walls, changing care needs of individuals and families, advancing technology, shifting settings of care delivery, and managing multiple transitions. The purpose of this paper is to consider these healthcare changes and share a …

Efficacy Of Herpes Zoster Vaccine, Kayla M. Stremick

Nursing Capstones

No abstract provided.

Rural Emergency Nurses’ Suggestions For Improving End-Of-Life Care, Renea L. Beckstrand, Kelly E. Smith, Karlen E. (Bethy) Luthy, Janelle L. B. Macintosh

Faculty Publications

Introduction: Many patient visits to emergency departments result in the patient dying or being pronounced dead on arrival. The numbers of deaths in emergency departments are likely to increase as a significant portion of the U.S. population ages. Consequently, emergency nurses face many obstacles to providing quality end-of-life (EOL) care when death occurs. The purpose of this study was to identify suggestions that emergency nurses have to improve EOL care, specifically in rural emergency departments.

Methods: A 57-item questionnaire was sent to 53 rural hospitals in 4 states in the Intermountain West, plus Alaska. One item asked nurses to identify …

The E2f4 Prognostic Signature Predicts Pathological Response To Neoadjuvant Chemotherapy In Breast Cancer Patients, Kenneth M. K. Mark, Frederick S. Varn, Matthew H. Ung, Feng Qian, Chao Cheng

Dartmouth Scholarship

Neoadjuvant chemotherapy is a key component of breast cancer treatment regimens and pathologic complete response to this therapy varies among patients. This is presumably due to differences in the molecular mechanisms that underlie each tumor’s disease pathology. Developing genomic clinical assays that accurately categorize responders from non-responders can provide patients with the most effective therapy for their individual disease. We applied our previously developed E2F4 genomic signature to predict neoadjuvant chemotherapy response in breast cancer. E2F4 individual regulatory activity scores were calculated for 1129 patient samples across 5 independent breast cancer neoadjuvant chemotherapy datasets. Accuracy of the E2F4 signature in …

The Effect Of Anxiety And Depression On College Students’ Academic Performance: Exploring Social Support As A Moderator, Katherine H. Bisson

Electronic Theses and Dissertations

The purpose of this study is to explore how social support is related to the overall well-being of college students. Literature suggests social support buffers a negative effect of distress on academic performance. This study attempts to provide practical information for a program called Student Opportunities, Advocacy, and Resources (SOAR) at Abilene Christian University (ACU), which assists students and connects them to resources available to support their path to success. A multiple linear regression was conducted to examine the association between anxiety, depression, social support, and academic performance using a sample of 93 students enrolled in this program in Fall …

Health & Kinesiology News, Georgia Southern University

Health Sciences & Kinesiology: News & Publications (2015-2023)

• Eagles Helping Eagles

Event Agenda, Lehigh Valley Health Network

Faculty Development

No abstract provided.

Abutment Disconnection/Reconnection Affects Peri-Implant Marginal Bone Levels: A Meta-Analysis, Theofilos Koutouzis, Fatemeh Gholami,, John Reynolds 2435439, Tord Lundgren, Georgios A. Kotsakis

Faculty Research, Publications, and Presentations

Purpose: Preclinical and clinical studies have shown that marginal bone loss can be secondary to repeated disconnection and reconnection of abutments that affect the peri-implant mucosal seal. The aim of this systematic review and meta-analysis was to evaluate the impact of abutment disconnections/reconnections on peri-implant marginal bone level changes.
Materials and Methods: To address this question, two reviewers independently performed an electronic search of three major databases up to October 2015 complemented by manual searches. Eligible articles were selected on the basis of prespecified inclusion and exclusion criteria after a two-phase search strategy and assessed for risk of bias. A …

A Novel Distractive And Mobility-Enabling Lumbar Spinal Orthosis For Treating Mechanical Low Back Pain, Daniel Clay Hillyard

Theses and Dissertations (ETD)

Introduction: Lumbar spinal orthoses (LSOs) are often used as non-surgical treatment and serve to support the spine and alleviate low back pain. More recently, dynamic orthoses claiming to decompress the spine have been introduced. Currently, there is an unserved population of people that suffer from mechanical low back pain (LBP) conditions, such as degenerative disc disease or lumbar foraminal stenosis, that would benefit from spinal decompression and mobility. A previously-developed prototype of dynamic mobility orthosis (DMO1) was designed that provided a distractive load across the lumbar spine but required higher sagittal bending moments and was unable to maintain spinal off-loading …

Healthnet News V.32:No.3 May-June 2017, Wendy Urciuoli

Articles - Patient Care

Linking Connecticut Patients and Families to Reliable Health Information

Place Events 2016-2017, Place

PLACE Historical Documents

This document describes PLACE events at Linfield College for 2016-2017.

Quantifying Joint Coordination Variability In Anterior Cruciate Ligament-Reconstructed Individuals During Walking, Kylie Davis

Theses and Dissertations (ETD)

The knee is the second most common joint to sustain injury. An estimated 200,000 anterior cruciate ligament (ACL) ruptures occur each year in the United States alone, and about 100,000 ACL reconstruction (ACLR) surgeries are performed annually. There is a significant risk of developing osteoarthritis of the knee after incurring an ACL injury, and the incidence of ipsilateral or contralateral injury is six times greater in individuals who have a surgically repaired ACL. Past studies have analyzed kinetic and kinematic characteristics of individual lower extremity joints to reveal differences between subjects with and without ACLR. Despite reports of altered kinematic …

Design, Validation, And Clinical Testing Of A Novel Fastening Device For A Scoliosis Brace, Cody Keith Bateman

Theses and Dissertations (ETD)

Each year, thirty thousand children in the US were put into a scoliosis brace. The primary function of scoliosis braces was to reduce and prevent progression of the spinal deformity as the patient grew by application of corrective forces to the spine. Straps, often made of Velcro, were attached to the back of the brace that applied forces to the spine when the straps were tightened. Braces were prescribed to be worn up to 23 hours a day. Studies have concluded that discomfort increased with increasing strap tension and pad pressure. They have also shown an increase in strap tension …

Effect Of Postprandial Walking On The Glycemic Effect Of A Meal: Type I Diabetes, Samantha L. Hinojosa

Theses & Dissertations

This study was conducted to determine if 15 minutes of postprandial light walking has an effect on the glycemic response to a Boost® beverage in individuals with type 1 diabetes. Seven participants, 22.3 + 4.3 yrs, with type 1 diabetes completed the two days of data collection. On day 1, participants measured baseline fasting blood glucose (BG) with a glucometer, consumed a Boost® beverage, and sat quietly, repeating BG measurements 15, 30, 60, 90, and 120 minute. On day 2, participants repeated the protocol, but walked 15 minutes at a light pace (50-60% max HR) immediately after beverage consumption. The …

Addressing Childhood Lead Poisoning Through Gis: A Proactive Approach In Scott County, Iowa, Tanner Osing

2016-2017: Scott County, Iowa and the Scott County Health Department

In June 2016, Scott County Health Department (SHCD) officially partnered with the Upper Mississippi Center (UMC) at Augustana College as part of the Sustainable Working Landscapes Initiative (SWLI). The initiative’s main goal is to address childhood lead poisoning in Scott County, Iowa. While the health department has ongoing efforts to address the problem, there are still approximately 50 children testing positive for lead poisoning every year (Tibbets, 2016). Currently, as part of the Childhood Lead Poisoning Prevention and Control Program, the health department offers case management services for children poisoned under the age of six, follow-up inspections for residences, and …

High-Content Screening Of Clinically Tested Anticancer Drugs Identifies Novel Inhibitors Of Human Mrp1 (Abcc1), Brian G. Perterson, Kee W. Tan, Bremansu Osa-Andrews, Surtaj H. Iram

Chemistry and Biochemistry Faculty Publications

Multidrug resistance protein 1 (MRP1/ABCC1), an integral transmembrane efflux transporter, belongs to the ATP-binding cassette (ABC) protein superfamily. MRP1 governs the absorption and disposition of a wide variety of endogenous and xenobiotic substrates including various drugs across organs and physiological barriers. Additionally, its overexpression has been implicated in multidrug resistance in chemotherapy of multiple cancers. Here, we describe the development of a high content imaging-based screening assay for MRP1 activity. This live cell-based automated microscopy assay is very robust and allows simultaneous detection of cell permeable, non-toxic and potent inhibitors. The validity of the assay was demonstrated by profiling a …

Conference Posters Archived In The Jefferson Digital Commons, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

The Jefferson Digital Commons has archived over 680 conference posters. Here are some of the most recent additions to the collection:

• Evaluating Value-Based Frameworks Used for Relapsed or Refractory Multiple Myeloma Regimens: ICER Report, ASCO Value Framework, and NCCN Evidence Blocks
• Looking Beyond the Traditional: Integrating a New Curriculum Design into an Immersion Practicum Evaluation Tool
• Infection Prevention and Control in Baccalaureate Nursing Education: Identifying Content, Teaching Strategies and Gaps
• Book Club at Intern Orientation to Help Frame Professional Identity

And many more posters!

Drunkorexia And The Motives Behind Substance Abuse And Eating Disorder Pathology Amongst College Culture, Nicole Caron, Ginette Gosselin Ferszt

Senior Honors Projects

Amongst college campuses throughout the United States, binge drinking has become a major concern. It seems to be integrated into campus culture, and considered “normal behavior”. However, binge drinking is not without its consequences. There are programs and educational materials which warn about the dangers of binge drinking. While binge drinking behaviors are common, there are other troublesome behaviors that are experienced amongst college students which are not discussed as often. In addition, there is an increase in the integration of binge drinking and eating disorder behaviors. This behavior is referred to as “drunkorexia”. Drunkorexia involves the exhibition of eating …

Kinetic Studies Of Dna Repair Enzyme Alkbh2, Michael R. Vittori

Senior Honors Projects

The genomes of living organisms are under constant bombardment from various sources, including chemical modification stemming from processes within the organisms themselves or from exogenous agents, and from radiation. These sources of genomic damage may induce structural changes in the genome’s most basic functional units, the nucleotides that comprise DNA. Damage to an organism’s DNA may result in the production of dysfunctional or nonfunctional proteins. Failure to repair such damage may result in the compounding of successive mutations within the organism’s genome, the pathogenesis of cancer and various genetic disorders in humans. To ensure their viability, organisms have developed unique …

Bleeding Ink: Creativity In Grief For Resilience, Gabriel E. Sayre

Senior Honors Projects

A venomous void pierces the present.

Emanating from the past, echoing to the future.

Seething sensations burrowing beneath the bone.

Seek a road, to not corrode.

Scribe or scribble, Scavenge salvation.

Settle cement of a new foundation.

Faceless fears fading,

weakening woes waning,

mending mentality.

Internally Inspired.

Transformation Transpired.

Grief After Death, Allison Mccormick

Senior Honors Projects

Child grief and bereavement are widely misunderstood and under addressed, frequently disenfranchising children and teens. Child and family bereavement centers are a crucial resource. I wanted to know how these non-profit organizations benefit young grievers from their own perspective.

To strengthen my understanding, I volunteered at FRIENDS WAY in Warwick, Rhode Island for six months to learn more about bereaved children and families and to assess how it serves this client group. A program evaluation was then conducted. Survey questions asked the participants about the value of their experiences, and which specific activities they find most helpful and most enjoyable. …

Ability Of Critical Care Medics To Confirm Endotracheal Tube Placement By Ultrasound, Michael Joyce

Health Sciences Education Symposium

Point of care ultrasound is rapidly becoming the standard of care for many different clinical applications. The ACLS guidelines were recently updated to include ultrasound confirmation of endotracheal tube placement. While physicians sometimes utilize this in hospital, it is not commonly used in a pre-hospital setting. We proposed teaching this skill using a simulation approach including hands on teaching combined with simulation of pathology.

Native Science In Practice: Cases For Broadening Understanding And Engagement Of Science In Education As A Plea For Future Generations, G. Sue Kasun, Dave López

Journal of Multicultural Affairs

We make a departure from the U.S.’s traditional “science education” in recognition of several stark realities—from the genocidal practices that have eliminated so many indigenous populations in the U.S. to the problems our planet faces, such dire environmental degradation. We are faced daily with a dissonance of knowing our planet needs our respect and care while at the same time bearing witness to “modern” lifestyles based in property rights and individualism. We engage Native science—which encapsulates all of Western science and expands upon it by including the spiritual and emotional realms as well as the physical and mental dimensions of …

Just-In-Time Education For Intensive Care Nurses, Rosemary D. Soriano

Nursing Masters

Background: Continuing education is fundamentally necessary to ensure ongoing competency of nurses in the Intensive Care Unit (ICU). There are many effective methods of continuing education, but there is a gap in continuing education for ICU nurses for high-risk low-frequency therapies (HRLFT).

Objectives: The purpose of this project was to determine if the implementation of Just-in-Time Education (JITE) for HRLFT in the Pediatric Intensive Care Unit (PICU) improved nurses’ feelings of competence, comfort, and safety when utilizing these interventions.

Methods: JITE checklists for nurses were developed for HRLFT in the PICU. The checklists were reviewed by the staff …

Quality Improvement In Pediatric Head Trauma With Pecarn Rules Implementation As Computerized Decision Support, Shireen M. Atabaki, Brian Jacobs, Kathleen Jacobs, Samira Shahzeidi, Nia Heard-Garris, Meghan Chamberlain, Robert Grell, James M. Chamberlain

Pediatrics Faculty Publications

Background: For the 1.4 million emergency department (ED) visits for traumatic brain injury (TBI) annually in the United States, computed tomography (CT) may be over utilized. The Pediatric Emergency Care Applied Research Network developed 2 prediction rules to identify children at very low risk of clinically important TBI. We implemented these prediction rules as decision support within our electronic health record (EHR) to reduce CT.

Objective: To test EHR decision support implementation in reducing CT rates for head trauma at 2 pediatric EDs.

Methods: We compared monthly CT rates 1 year before [preimplementation (PRE)] and 1 year after [postimplementation (POST)] …

Effects Of Ankle Weights On Metabolic Response And Muscle Activity On A Lower Body Positive Pressure Treadmill 2017, Saige Hupman

Master's Theses

Lower body positive pressure (LBPP) treadmills are growing in popularity for rehabilitative use, as the benefits of exercising at partially supported body weight may induce faster recovery. It is unknown if there are certain practices that increase exercise intensity while maintaining positive effects of LBPP. Adding ankle weights when walking or running could increase intensity of rehabilitation programs while maintaining the comfort of supported body weight. PURPOSE: To measure metabolic response (VO2, RER, HR, Caloric expenditure), RPE, and lower limb electromyography (EMG) amplitudes of LBPP treadmill walking and running with and without ankle weights. METHODS: Sixteen participants (Age: 21.94 ± …