Medicine and Health Sciences Commons^™

Deconstructing Medicine: The Intersections Of Racism And Health Disparities Within Pre-Medical Education, Allison F. Dormanesh

Ethnic Studies

The purpose of this project is to evaluate ways in which historical racism and lack of it in pre- medical curriculum shapes future health professionals and results in negative medical treatment of under-represented groups. Research found in the literature review reveals a strong history of racism within medical practice and medical research, as well as unconscious bias that follows knowledge taught during undergraduate education and onwards. An intersectionality approach is used to show the affect of race and class on health disparities and unethical abuse. This research includes data analyzing the pre-medical curriculums of the ten pre-medical universities that produce …

Volume Vi (2017), Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

Prevalence And Prognostic Features Of Ecg Abnormalities In Acute Stroke: Findings From The Siren Study Among Africans, Abiodun M. Adeoye, Okechukwu S. Ogah, Bruce Ovbiagele, Rufus Akinyemi, Vincent Shidali, Francis Agyekum, Akinyemi Aje, Oladimeji Adebayo, Joshua O. Akinyemi, Philip Kolo, Lambert Tetteh Appiah, Henry Iheonye, Uwanuruochi Kelechukwu, Amusa Ganiyu, Taiwo O. Olunuga, Onoja Akpa, Ojo Olakanmi Olagoke, Fred Stephen Sarfo, Kolawole Wahab, Samuel Olowookere, Adekunle Fakunle, Albert Akpalu, Philip B. Adebayo, Kwadwo Nkromah, Joseph Yaria, Philip Ibinaiye, Godwin Ogbole, Aridegbe Olumayowa, Sulaiman Lakoh, Benedict Calys-Tagoe, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

Background

Africa has a growing burden of stroke with associated high morbidity and a 3-year fatality rate of 84%. Cardiac disease contributes to stroke occurrence and outcomes, but the precise relationship of abnormalities as noted on a cheap and widely available test, the electrocardiogram (ECG), and acute stroke outcomes have not been previously characterized in Africans.

Objectives

The study assessed the prevalence and prognoses of various ECG abnormalities among African acute stroke patients encountered in a multisite, cross-national epidemiologic study.

Methods

We included 890 patients from Nigeria and Ghana with acute stroke who had 12-lead ECG recording within first 24 …

Genetic Associations With Lipoprotein Subfraction Measures Differ By Ethnicity In The Multi-Ethnic Study Of Atherosclerosis (Mesa), Zhe Wang, Ani Manichukal, David C. Goff, Samia Mora, Jose M. Ordovas, Nicholas M. Pajewski, Wendy S. Post, Jerome I. Rotter, Michele M. Sale, Stephanie A. Santorico, David Siscovick, Michael Y. Tsai, Donna K. Arnett, Stephen Rich, Alexis C. Frazier-Wood

Epidemiology and Environmental Health Faculty Publications

A recent genome-wide association study associated 62 single nucleotide polymorphisms (SNPs) from 43 genomic loci, with fasting lipoprotein subfractions in European–Americans (EAs) at genome-wide levels of significance across three independent samples. Whether these associations are consistent across ethnicities with a non-European ancestry is unknown. We analyzed 15 lipoprotein subfraction measures, on 1677 African–Americans (AAs), 1450 Hispanic–Americans (HAs), and 775 Chinese–Americans (CHN) participating in the multi-ethnic study of atherosclerosis (MESA). Genome-wide data were obtained using the Affymetrix 6.0 and Illumina HumanOmni chips. Linear regression models between genetic variables and lipoprotein subfractions were adjusted for age, gender, body mass index, smoking, study …

Anatomical And Behavioral Investigation Of C1ql3 In The Mouse Suprachiasmatic Nucleus, David C. Martinelli

UCHC Articles - Research

Many biochemical, physiological, and behavioral processes such as glucose metabolism, body temperature, and sleep-wake cycles show regular daily rhythms. These circadian rhythms are adjusted to the environmental light-dark cycle by a central pacemaker located in the suprachiasmatic nucleus (SCN) in order for the processes to occur at appropriate times of day. Here, we investigated the expression and function of a synaptic organizing protein, C1QL3, in the SCN. We found that C1ql3 is robustly expressed in the SCN. C1ql3 knockout mice have a reduced density of excitatory synapses in the SCN. In addition, these mice exhibited less consolidated activity to the …

Progression Magazine, 2017 Summer, Coastal Carolina University

Progression Magazine

Magazine of the College of Science at Coastal Carolina University.

Effect Of Corticosteroid On Safety And Efficacy For Actinic Keratosis Therapy With Ingenol Mebutate, Shreya Amin

Yale School of Medicine Physician Associate Program Theses

Actinic keratoses are common premalignant lesions that occur in fair-skinned individuals with high cumulative ultraviolet exposure. Monotherapy with ingenol mebutate has been known to cause local skin reactions, such as erythema, which reduces safety. Clobetasol propionate has worked well with other actinic keratosis therapies to reduce inflammation, but its role with ingenol mebutate is not well understood. The effect of concurrent application of clobetasol propionate with ingenol mebutate to reduce local skin reactions without impacting efficacy has not yet been investigated. We are proposing a superiority trial for safety as well as a non-inferiority trial for effectiveness. We will conduct …

Reducing Mortality From Septic Shock Using An Interleukin-1 Receptor Antagonist, Juyeon Chung

Yale School of Medicine Physician Associate Program Theses

Septic shock, a severe inflammatory state secondary to a bacterial infection with refractory hypotension and tissue hypoperfusion despite adequate fluid resuscitation, is a leading cause of mortality in intensive care units worldwide. The mortality rate of septic shock patients can exceed 40% in the U.S., highlighting the need for more effective therapies. Anakinra, an inflammatory cytokine inhibitor, has been identified as a potential therapy for reducing various inflammatory states such as sepsis. Our aim is to evaluate the efficacy of anakinra in reducing mortality in patients with septic shock. This double-blind, randomized control trial will compare the 28-day mortality of …

Youth Program Adult Leader's Directive Assistance And Autonomy Support And Development Of Adolescents’ Agency Capacity, David Hansen, E. Whitney Moore, Nadia Jessop

Kinesiology, Health and Sport Studies

Developing a capacity for exercising agency is an important developmental task of adolescence. Many organized youth programs provide adolescents opportunities to build their capacity to exercise agency. The researchers tested hypotheses that adult youth program leader's directive assistance and autonomy support would promote adolescents’ capacity for agency. They surveyed 441 high school adolescents and 11 adult advisors from 10 Future Farmers of America chapters twice over 2 years. Adolescents self‐reported on their capacity for agency and advisors reported on each adolescent's capacity. Directive assistance and autonomy support correlated with the capacity for agency within both time points. Only autonomy support …

Satisfaction Among Early And Mid-Career Dentists In A Metropolitan Dental Hospital In China, Xiaoxi Cui, David G. Dunning, Na An

Journal Articles: College of Dentistry

A growing body of research has examined career satisfaction among dentists using a standardized instrument, dentist satisfaction survey (DSS). This project examined career satisfaction of early to mid-career dentists in China, a population whose career satisfaction, heretofore, has not been studied. This is an especially critical time to examine career satisfaction because of health care reform measures being implemented in China. A culturally sensitive Chinese-language version of the DSS (CDSS) was developed and electronically administered to 367 early and mid-career dentists in a tertiary dental hospital in Beijing, China. One hundred and seventy respondents completed the survey. The average total …

Practical Pearl: Prenatal Screening, Mary-Alice Abbott Md

Pediatrics Practical Pearls: Referral Guidelines for Common Problems

No abstract provided.

Subsets Of Inflammatory Cytokine Gene Polymorphisms Are Associated With Risk Of Carcinogenic Liver Fluke Opisthorchis Viverrini-Associated Advanced Periductal Fibrosis And Cholangiocarcinoma., Arpa Surapaitoon, Sutas Suttiprapa, Eimorn Mairiang, Narong Khuntikeo, Chawalit Pairojkul, Jeffrey Bethony, Paul J Brindley, Banchob Sripa

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Opisthorchis viverrini infection induces chronic inflammation, and a minor proportion of infected individuals develop advanced periductal fibrosis (APF) and cholangiocarcinoma (CCA). Inflammatory cytokines and/or their gene polymorphisms may link to these biliary pathologies. We therefore investigated associations among cytokine gene polymorphisms and cytokine production in 510 Thai cases infected with O. viverrini who presented with APF+ or APF−, as established by abdominal ultrasonography as well as in patients diagnosed with CCA. Levels of pro-inflammatory and anti-inflammatory cytokines were determined in culture supernatants after stimulation of peripheral blood mononuclear cells (PBMCs) with O. viverrini excretory-secretory (ES) products. Pro-inflammatory cytokines, IL-1β, IL-6, …

Complete Congenital Heart Block: A Case Of Multilevel Block., Ian W Hovis, David N Schidlow, Jeffrey P Moak

Pediatrics Faculty Publications

No abstract provided.

Corneal Edema And Keratitis Following Selective Laser Trabeculoplasty, E T. Liu, L S. Seery, A Arosemena, Tania Lamba, C J. Chaya

Ophthalmology Faculty Publications

Purpose

To describe three cases of keratitis following Selective Laser Trabeculoplasty(SLT).

Observations

Three females with a history of glaucoma presented with corneal edema, keratitis (endothelial, epithelial) and decreased visual acuity shortly after SLT. There was variable resolution of symptoms after starting treatment with oral antiherpetics and topical steroids.

Conclusions and importance

With the increase in usage of SLT as a treatment for glaucoma and subsequent reports of keratitis, it is imperative for ophthalmic surgeons to be aware of herpes simplex as a possible risk factor. Prompt treatment with antivirals and steroids can potentially prevent scarring and permanent …

Upsee Daisy! Gross Motor Outcomes After Dynamic Weight Bearing In Two Children With Truncal Hypotonia: A Case Series, Megan Flores, Kathleen Manella, Elizabeth Ardolino

Physical Therapy Collection

PURPOSE: The purpose of this case series was to report the impact of a home-based dynamic standing program on postural control and gross motor activity in two children with truncal hypotonia.

BACKGROUNDS/SIGNIFICANCE: Poor postural control associated with central hypotonia limits a child’s ability to interact with the environment, delaying attainment of developmental milestones such as sitting, crawling, standing and walking. Participation in social interactions with peers and caregivers may be restricted resulting in a decreased quality of life. Supported standing programs are commonly used to ameliorate impairments and optimize function in children with poor postural control. Increased social interactions, …

Nitro-Triarylmethyl Radical As Dual Oxygen And Superoxide Probe, Benoit Driesschaert, Andrey A. Bobko, Valery V. Khramtsov, Jay L. Zweier

Clinical and Translational Science Institute

Superoxide radical is involved in numerous physiological and pathophysiological processes. Tetrathiatriarylmethyl (TAM) radicals are knows to react with superoxide allowing measurement of superoxide production in biological media. We report the synthesis of a Nitro conjugated TAM radical showing a rate constant of 7 × 105 M−1s−1 which is two order of magnitude higher than other TAMs allowing high sensitivity measurement of superoxide

Concurrent Longitudinal Epr Monitoring Of Tissue Oxygenation, Acidosis, And Reducing Capacity In Mouse Xenograft Tumor Models, Andrey A. Bobko, Jason Evans, Nicholas C. Denko, Valery V. Khramtsov

Clinical and Translational Science Institute

Tissue oxygenation, extracellular acidity and tissue reducing capacity are among crucial parameters of tumor microenvironment (TME) of significant importance for tumor pathophysiology. In this paper we demonstrate the complementary application of particulate lithium octa-n-butoxy-naphthalocyanine (LiNc-BuO) and soluble nitroxide (NR) paramagnetic probes for monitoring of these TME parameters using electron paramagnetic resonance (EPR) technique. Two different types of therapeutic interventions were studied: hypothermia and systemic administration of metabolically active drug. In summary, the results demonstrate utility of EPR technique for noninvasive concurrent longitudinal monitoring of physiologically relevant chemical parameters of TME in a mouse xenograft tumor models including that under therapeutic …

Osteoblast Differentiation And Bone Matrix Formation In Vivo And In Vitro, Harry C. Blair, Quitterie C. Larrouture, Yanan Li, Hang Lin, Donna Beer-Stoltz, Li Liu, Rocky S. Tuan, Lisa J. Robinson, Paul H. Schlesinger, Deborah J. Nelson

Clinical and Translational Science Institute

We review the characteristics of osteoblast differentiation and bone matrix synthesis. Bone in air breathing vertebrates is a specialized tissue that developmentally replaces simpler solid tissues, usually cartilage. Bone is a living organ bounded by a layer of osteoblasts that, because of transport and compartmentalization requirements, produce bone matrix exclusively as an organized tight epithelium. With matrix growth, osteoblasts are reorganized and incorporated into the matrix as living cells, osteocytes, which communicate with each other and surface epithelium by cell processes within canaliculi in the matrix. The osteoblasts secrete the organic matrix, which are dense collagen layers that alternate parallel …

Endoscopic Endonasal Transclival Approach Versus Dual Transorbital Port Technique For Clip Application To The Posterior Circulation: A Cadaveric Anatomical And Cerebral Circulation Simulation Study, Jeremy N. Ciporen, Brandon Lucke-Wold, Aclan Dogan, Justin Cetas, William Cameron

Clinical and Translational Science Institute

Purpose  Simulation training offers a useful opportunity to appreciate vascular anatomy and develop the technical expertise required to clip intracranial aneurysms of the posterior circulation. Materials and Methods  In cadavers, a comparison was made between the endoscopic transclival approach (ETA) alone and a combined multiportal approach using the ETA and a transorbital precaruncular approach (TOPA) to evaluate degrees of freedom, angles of visualization, and ergonomics of aneurysm clip application to the posterior circulation depending on basilar apex position relative to the posterior clinoids. Results  ETA alone provided improved access to the posterior circulation when the basilar apex was high riding …

Rates Of Nonsteroidal Anti-Inflammatory Drug Use In Patients With Established Cardiovascular Disease: A Retrospective, Cross-Sectional Study From Nhanes 2009- 2010, Gregory Castelli, Ashley Petrone, Jun Xiang, Carl Shrader, Dana King

Clinical and Translational Science Institute

Purpose—Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat pain, inflammation, and fever in the USA. Unfortunately, NSAIDs have been associated with an increased risk of adverse cardiovascular events, especially among NSAID users with established cardiovascular disease (CVD). In 2005, the Food and Drug Administration (FDA) released an initial warning regarding NSAID use and CVD risk, and recently, in July 2015, released an updated statement strengthening this initial warning. The purpose of this study is to evaluate the rates of NSAID use among patients with CVD following the 2005 FDA warning regarding NSAID use and increased CVD risk. Methods—This was …

Dissemination Approaches To Participating Primary Care Providers In A Quality Improvement Program Addressing Opioid Use In Central Appalachia, Roberto Cardarelli, Charlotte Sue Workman, Sarah Weatherford, Stacey Whanger, Dana E. King

Clinical and Translational Science Institute

Objectives—Practice-based research networks (PBRNs) have been described as new clinical laboratories for primary care research and dissemination. PBRNs, however, have struggled to disseminate research results in a meaningful way to participating providers and clinics. Methods—The Central Appalachia Inter-Professional Pain Education Collaborative was developed to work with PBRN clinics using quality improvement methods, deliver statewide continuing education activities to address the issue of opioid use in patients with chronic pain, and develop a multimodal mechanism to disseminate project results to clinics and participating providers. Results—Successful change in the delivery of chronic pain care was dependent on the clinic’s commitment to a …

Intracardiac Versus Transesophageal Echocardiography To Guide Transcatheter Closure Of Interatrial Communications: Nationwide Trend And Comparative Analysis, Fahad Alqahtani, Ashwin Bhirud, Sami Aljohani, James Mills, Akram Kawsara, Ashok Runkana, Mohamad Alkhouli

Clinical and Translational Science Institute

Objectives—This study aimed to assess current temporal trends in utilization of ICE versus TEE guided closure of interatrial communications, and to compare periprocedural complications and resource utilization between the two imaging modalities. Background—While transesophageal echocardiography (TEE) has historically been used to guide percutaneous structural heart interventions, intracardiac echocardiography (ICE) is being increasingly utilized to guide many of these procedures such as closure of interatrial communications. Methods—Using the Nationwide Inpatient Sample, all patients aged >18 years, who underwent ASD or PFO closure with either ICE or TEE guidance between 2003 and 2014 were included. Comparative analysis of outcomes and resource utilization …

Comparison Of Particle Beam Therapy And Stereotactic Body Radiotherapy For Early Stage Non-Small Cell Lung Cancer: A Systematic Review And Hypothesis-Generating Meta-Analysis, Alexander Chi, Haiquan Chen, Sijin Wen, Haijuan Yan, Zhongxing Liao

Clinical and Translational Science Institute

Purpose—To assess hypo-fractionated particle beam therapy (PBT)'s efficacy relative to that of photon stereotactic body radiotherapy (SBRT) for early stage (ES) non-small cell lung cancer (NSCLC). Methods—Eligible studies were identified through extensive searches of the PubMed, Medline, Google-scholar, and Cochrane library databases from 2000 to 2016. Original English publications of ES NSCLC were included. A meta-analysis was performed to compare the survival outcome, toxicity profile, and patterns of failure following each treatment. Results—72 SBRT studies and 9 hypo-fractionated PBT studies (mostly single-arm) were included. PBT was associated with improved overall survival (OS; p = 0.005) and progression-free survival (PFS; p …

Exploring Adenosine Receptor Ligands: Potential Role In The Treatment Of Cardiovascular Diseases, Werner J. Geldenhuys, Ahmad Hanif, June Yun, Mohammed A. Nayeem

Clinical and Translational Science Institute

Cardiovascular diseases remain the number one diseases affecting patients’ morbidity and mortality. The adenosine receptors are G-protein coupled receptors which have been of interest for drugs target for the treatment of multiple diseases ranging from cardiovascular to neurological. Adenosine receptors have been connected to several biological pathways affecting the physiology and pathology of the cardiovascular system. In this review, we will cover the different adenosine receptor ligands that have been identified to interact with adenosine receptors and affect the vascular system. These ligands will be evaluated from clinical as well as medicinal chemistry perspectives with more emphasis on how structural …

Concomitant Medication Use And New-Onset Diabetes Among Medicaid Beneficiaries With Chronic Obstructive Pulmonary Disease, Mayank Ajmera, Chan Shen, Usha Sambamoorthi

Clinical and Translational Science Institute

Use of multiple prescription medications is common among individuals with chronic obstructive pulmonary disease (COPD) because of coexisting inflammatory-related conditions. Specifically, the use of antidepressants, inhaled corticosteroids (ICSs), and statins may place individuals with COPD at high risk for new-onset diabetes. The objective was to examine the relationship between the use of antidepressants, ICSs, and statins and new-onset diabetes among Medicaid beneficiaries with COPD. This study used a retrospective longitudinal cohort design using multiple years (2005–2008) of Medicaid claims for beneficiaries with newly diagnosed COPD (n = 15,287), who were diabetes free at baseline. National Drug Codes were used …

Longitudinal Analyses Of The Sexual And Reproductive Health Knowledge And Parent-Adolescent Communication Of At-Risk Adolescents, Courage Chikomborero Mudzongo

Faculty Publications - Doctor of Psychology (PsyD) Program

Despite declining rates, unintended adolescent pregnancy remains a considerable public health challenge in the United States (Hamilton, Martin, & Osterman, 2015). Unintended pregnancy leads to a host of negative outcomes not only for adolescents, but also for their children who are more likely to get trapped in a cycle of poverty that is difficult to break (Rew & Wong, 2006). Factors such as poverty are difficult to address; nonetheless, sexual reproductive health (SRH) knowledge and parent-adolescent communication (PAC) have been identified as important tools for prevention, and potentially modifiable (Swenson et al., 2009; 2010). The goal of the current study …

Influence Of Silver Nanoparticle Surface Charge On Cytotoxic Efficacy Against Cancer Cells, Elliot Christian Frey

Materials Engineering

Silver and silver-based products are known to cause cytotoxic effects to both microbes and eukaryotic cells. Because of this property, silver nanoparticles (AgNPs) are being studied for their potential in targeted tumor treatments. Previous studies with microbes suggest that AgNPs with cationic capping agents possess enhanced cytotoxicity by virtue of Coulombic attraction between the nanoparticle and the negatively-charged cell wall. Since animal cells possess similar negatively-charged plasma membranes, this research hypothesized that human cells would be more susceptible to positively-charged AgNPs than to negatively-charged AgNPs. To investigate this theory, cancerous cervical cells (HeLa) and healthy fibroblast cells (3T3) were subjected …

Exploring Overlaps Between The Genomic And Environmental Determinants Of Lvh And Stroke: A Multicenter Study In West Africa, Abiodun M. Adeoye, Bruce Ovbiagele, Philip Kolo, Lambert Appiah, Akinyemi Aje, Oladimeji Adebayo, Fred Sarfo, Joshua Akinyemi, Gregory Adekunle, Francis Agyekum, Vincent Shidali, Okechukwu Ogah, Dan Lackland, Mulugeta Gebregziabher, Donna K. Arnett, Hemant K. Tiwari, Rufus Akinyemi, Ojo Olakanmi Olagoke, Ayodipupo Sikiru Oguntade, Taiwo Olunuga, Kelechi Uwanruochi, Carolyn Jenkins, Patrick Adadey, Henry Iheonye, Lukman Owolabi, Reginald Obiako, Samuel Akinjopo, Kevin Armstrong, Albert Akpalu, Adekunle Fakunle

Epidemiology and Environmental Health Faculty Publications

Background

Whether left ventricular hypertrophy (LVH) is determined by similar genomic and environmental risk factors with stroke, or is simply an intermediate stroke marker, is unknown.

Objectives

We present a research plan and preliminary findings to explore the overlap in the genomic and environmental determinants of LVH and stroke among Africans participating in the SIREN (Stroke Investigative Research and Education Network) study.

Methods

SIREN is a transnational, multicenter study involving acute stroke patients and age-, ethnicity-, and sex-matched control subjects recruited from 9 sites in Ghana and Nigeria. Genomic and environmental risk factors and other relevant phenotypes for stroke and …

간호대학생의 노인 간호의도에 영향을 미치는 요인, Phoebe (Yeon) S. Kim, Insun Jang

Nursing Faculty Publications

No abstract provided.

Bioactive Growth Hormone In Older Men And Women: Its Relationship To Immune Markers And Healthspan, William J. Kraemer, Mary J. Kennett, Andrea M. Mastro, Roger J. Mccarter, Connie J. Rogers, William H. Dupont, Shawn D. Flanagan, William J. Turbitt, Maren S. Fragala, Emily M. Post, Wesley C. Hymer

Health and Sport Sciences Faculty Scholarship

Objective: The consequences of age-related decline in the somatotropic axis of humans are complex and remain largely unresolved. We tested the hypothesis that hGH measurements of plasma by bioassay vs immunoassay from samples obtained from free-living, elderly individuals would reveal a dichotomy in GH activities that are correlated with the functional status of the donors, i.e. their healthspan.

Design: Forty-one men and women of advanced age (men: N=16, age, 80.5±6.5years; height, 173.1±6.9cm; body mass, 81.8±13.0kg) and (women: N=25, age, 80.7±7.2years; height, 157.7±6.0cm; body mass, 68.8±17kg), were recruited for a cross-sectional study. Participants filled out PROMIS (Patient-Reported Outcomes Measurement Information System, …