Medicine and Health Sciences Commons^™

Inim Presents The South Florida Premiere Of The Sundance Award Winning Film, Unrest, Nova Southeastern University

Institute for Neuro-Immune Medicine Presentations

No abstract provided.

Characterization Of Antibiotic Use Within Pediatric Patients With Cystic Fibrosis., Elizabeth Shober Pharmd, Kristin M. Held Wheatley Pharmd, Bcop

Department of Pharmacy

No abstract provided.

Doula Services Within A Healthy Start Program: Increasing Access For An Underserved Population, Mary-Powel Thomas, Gabriela Ammann, Ellen Brazier, Philip Noyes, Aletha Maybank

Publications and Research

Purpose: Women of color in the United States, particularly in high-poverty neighborhoods, experience high rates of poor birth outcomes, including cesarean section, preterm birth, low birthweight, and infant mortality. Doula care has been linked to improvements in many perinatal outcomes, but women of color and low-income women often face barriers in accessing doula support.

Description: To address this issue, the New York City Department of Health and Mental Hygiene’s Healthy Start Brooklyn introduced the By My Side Birth Support Program in 2010. The goal was to complement other maternal home-visiting programs by providing doula support during labor and birth, along …

Effect Of Hyperchloremia On Acute Kidney Injury In Critically Ill Septic Patients: A Retrospective Cohort Study, Lenar Yessayan, Javier A. Neyra, Fabrizio Canepa-Escaro, George Vasquez-Rios, Michael Heung, Jerry Yee, Acute Kidney Injury In Critical Illness Study Group

Internal Medicine Faculty Publications

Background: Hyperchloremia is common in critically ill septic patients. The impact of hyperchloremia on the incidence of acute kidney injury (AKI) is not well studied. We investigated the association between hyperchloremia and AKI within the first 72 h of intensive care unit (ICU) admission.

Methods: 6490 ICU adult patients admitted with severe sepsis or septic shock were screened for eligibility. Exclusion criteria included: AKI on admission, baseline estimated glomerular filtration rate (eGFR) < 15 ml/min/1.73 m², chronic renal replacement therapy, absent baseline serum creatinine data, and absent serum chloride data on ICU admission.

Results: A total of 1045 patients were available for …

Impact Of A Transition Of Care Pharmacy Program On A Medical-Surgical Unit On 30-Day Readmission Rates., Kyle O'Brien Pharmd, Kristin M. Held Pharmd, Bcop, Jennifer E. Macfarlan Mph, Elie Jabbour Pharmd, Mba

Department of Pharmacy

No abstract provided.

Pretargeting Of Internalizing Trastuzumab And Cetuximab With A 18f-Tetrazine Tracer In Xenograft Models, Outi Keinänen, Kimberly Fung, Jacob Pourat, Vilma Jallinoja, Delphine Vivier, Nagavara Kishore Pillarsetty, Anu J. Airaksinen, Jason S. Lewis, Brian M. Zeglis, Mirkka Sarparanta

Publications and Research

Background: Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient. To date, only a few studies have used short-lived radioisotopes for pretargeting of antibodies, and such examples with internalizing antibodies are even rarer. Herein, we have investigated pretargeting methodology using inverse electron-demand Diels-Alder (IEDDA) for tracing two clinically relevant, internalizing monoclonal antibodies, cetuximab and trastuzumab.

Results: Bioorthogonal reaction between tetrazine and trans-cyclooctene (TCO) was used for tracing cetuximab and trastuzumab in vivo with a fluorine-18 (t½ = 109.8 min) labelled tracer. TCO-cetuximab or TCO-trastuzumab was administered 24, 48, or 72 …

Intermediate-Term Risk Of Stroke Following Cardiac Procedures In A Nationally Representative Data Set., Laura Stein, Alison Thaler, John W. Liang, Stanley Tuhrim, Amit S. Dhamoon, Mandip S. Dhamoon

Department of Neurology Faculty Papers

BACKGROUND: Studies on stroke risk following cardiac procedures addressed only perioperative and long-term risk following limited higher-risk procedures, were poorly generalizable, and often failed to stratify by stroke type. We calculated stroke risk in the intermediate risk period following cardiac procedures compared with common noncardiac surgeries and medical admissions.

METHODS AND RESULTS: The Nationwide Readmissions Database contains readmission data for 49% of US admissions in 2013. We compared age-adjusted stroke readmission rates up to 90 days postdischarge. We used Cox regression to calculate hazard ratios, up to 1 year, of stroke risk comparing transcatheter aortic valve replacement versus surgical aortic …

Perceptual And Physiologic Analysis Of Dystussia In Amyotrophic Lateral Sclerosis, Stephanie Anne Watts

USF Tampa Graduate Theses and Dissertations

Swallowing and cough are two vital functions that are reflexive in nature and are related to each other in terms of shared neural and anatomical space. When a disorder impacts normal and effective swallowing and/or cough, the consequences can be life-threatening. Evaluation and treatment of swallowing and cough disorders can fall under the scope of practice of the speech-language pathologist and speech-language pathologists often are leading professionals. Furthermore, much of the current research on swallowing and cough is spearheaded by speech-language pathologists often working with a multi-disciplinary team. The focus of this dissertation is on the clinical evaluation of cough …

Severe Recurrent Hypothermia In An Elderly Patient With Refractory Mania Associated With Atypical Antipsychotic, Valproic Acid And Oxcarbazepine Therapy, Oluwadamilare O. Ajayi, Suzanne Holroyd

Psychiatry

Hypothermia is a rare but serious condition that has been associated with various psychiatric medications. We present a 76-year-old woman with refractory mania who developed multiple episodes of severe hypothermia associated with several psychiatric medications including olanzapine, quetiapine, valproic acid and oxcarbazepine. These episodes resolved following discontinuation of the agents. The patient had never experienced hypothermia before, despite having been on these or similar agents for many years. With traditional treatments for mania not feasible, other medications were used to treat her including lithium, clonazepam, gabapentin and the novel protein kinase c inhibitor tamoxifen. The regimen resulted in some success …

Setting Priorities For Knowledge Translation Of Cochrane Reviews For Health Equity: Evidence For Equity, Peter Tugwell, Jennifer Petkovic, Vivian Welch, Jennifer Vincent, Zulfiqar Ahmed Bhutta, Rachel Churchill, Don Desavigny, Lawrence Mbuagbaw, Tomas Pantoja

Department of Paediatrics and Child Health

Background: A focus on equity in health can be seen in many global development goals and reports, research and international declarations. With the development of a relevant framework and methods, the Campbell and Cochrane Equity Methods Group has encouraged the application of an 'equity lens' to systematic reviews, and many organizations publish reviews intended to address health equity. The purpose of the Evidence for Equity (E4E) project was to conduct a priority-setting exercise and apply an equity lens by developing a knowledge translation product comprising summaries of systematic reviews from the Cochrane Library. E4E translates evidence from systematic reviews into …

Going For The Trunk, Nicholas G. Norwitz

Dartmouth Undergraduate Journal of Science

Although angiogenesis (new blood vessel formation) is an absolute requirement for tumor growth, therapies designed to treat cancer by targeting specific angiogenic factors have had limited success. One theory is that there are many different angiogenic factors that can compensate for the loss of a single factor. Therefore, a more effective strategy may be to move upstream, identify a factor that regulates the expression of many different downstream angiogenic mediators, and then measure the effect of blocking this single common factor on angiogenesis-mediated tumor growth.

Uncertain Influences: Genetics, Pathology, And Alzheimer’S Disease, Sumita M. Strander

Dartmouth Undergraduate Journal of Science

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that primarily affects individuals above the age of 65 and is often associated with memory loss, one of its chief symptoms. Although it was first discovered by Alois Alzheimer in 1906, AD has only recently garnered attention proportionate to the impact it is expected to have as the world’s population ages at increasing rates. Despite the certainty of this its importance, there is much the medical and scientific communities do not know about the etiology of this disease. This paper will discuss a few of the reasons for this lack of knowledge …

The World Of Placebos, Zachary Z. Wang

Dartmouth Undergraduate Journal of Science

The Placebo Effect is a fascinating but poorly understood mystery of medicine and human biology. Its workings continue to surprise scientists and patients everywhere. This is a brief introduction to the placebo effect from its early roots to current issues and new discoveries in the field.

Telesurgery: Surgery In The Digital Age, Dylan J. Cahill

Dartmouth Undergraduate Journal of Science

The dawn of the digital age has transformed the way we now receive and provide healthcare. Today, providers have instant access to all of their patients’ information, just as patients can connect with their providers on their smartphones in minutes from nearly anywhere in the world.

Lyme Disease: An Influential Outdoor Hazard, Kevin Kang

Dartmouth Undergraduate Journal of Science

Lyme disease is an important, common illness in New England. A relatively new illness, it was discovered about forty years ago in the town of Lyme, Connecticut. Now, it has become the most common vector-transmitted illness in the United States, with over 30,000 cases annually. Lyme disease arises when a bacterium is transmitted to a human via deer tick bite, so those of us involved in outdoor sports are most likely to contract the disease. Inhabitants of New England and the northeastern U.S. are most vulnerable to the disease, as 95% of Lyme Disease cases occur in only 14 out …

Towards Simulating The Human Brain, Logan T. Collins

Dartmouth Undergraduate Journal of Science

The human brain has been described as “the most complex object in the universe.” Its meshwork of 86 billion neurons,84 billion glial cells, and over 150 trillion synapses may seem intractable. Nonetheless, efforts to comprehensively map, understand, and even computationally reproduce this structure are underway. Large collectives of researchers have come together, working in concert towards these goals. The Human Brain Project (HBP) and its precursor, the Blue Brain Project, have spearheaded the brain simulation goal.Some other notable organizations include the China Brain Project, the BRAIN Initiative. On a scale which parallels the space program and the Human Genome Project, …

Individualized Glycemic Targets For The Elderly Residing In Long Term Care Facilities, Abegail Hubberd

Doctor of Nursing Practice

Of people age 65 and older residing in a long-term care facility, 1 in 4 has Type 2 diabetes (Smide & Nygren, 2013). Care and management of this population is a challenge for nurses and other providers. Results of a needs assessment in a local long-term care facility identified deficiencies in the provision of evidence-based Type 2 diabetes care for this target population. American Diabetes Association Guidelines (2017) recommend application of individualized HbA1c targets for the elderly residing in long-term care facilities, especially for those with compromises in clinical and functional status. This two prong quality improvement project strove to …

Achieving Totally Local Anticoagulation On Blood Contacting Devices, Rana Gbyli, Anna Mercaldi, Harihara Sundaram, Kagya Amoako

Mechanical and Industrial Engineering Faculty Publications

The recent years have witnessed an increased activity in biocompatibility research aimed at limiting biomaterial-induced blood coagulation. From 2008 to 2016, a total of $36,946,764.00 USD was awarded in grants to 213 research proposals and as large as 50.4% ($18,627,854.00) of that award monies were distributed to 101 proposals over the fiscal years of FY14 to FY16 alone. However, the complexity in blood responses to biomaterials, variability in blood function between individuals and animal species, and differences in medical device application and test setting all continue to pose difficulties in making a breakthrough in this field. This review focuses on …

A Mixed-Methods Study: An Examination Of The Relationship Between Private Social Media Participation And Accountability, Adherence, And Social Connectedness In, Diana A. Cabori

Dissertations

Purpose: The purpose of this mixed-methods sequential explanatory study was to examine the influence of private social media usage on accountability, adherence, and social connectedness in weight loss and fitness program participants.

Methodology: This study utilized a mixed-methods sequential explanatory research design comprised of a multi-state quantitative survey of weight loss and fitness participants and subsequent qualitative interviews to elucidate the influence of private social media on weight loss and fitness program participants regarding program accountability and adherence, and social connectedness to others. The population included 3,000 participants of The Camp Transformation Center and 1,000 participants of Warrior Fitness and …

Progression Magazine, 2017 Winter, Coastal Carolina University

Progression Magazine

Magazine of the College of Science at Coastal Carolina University.

Critical Appraisal Tools And Reporting Guidelines For Evidence-Based Practice, Robin Buccheri, Claire Olivia Sharifi

Gleeson Library Faculty and Staff Research and Scholarship

Background: Nurses engaged in evidence-based practice (EBP) have two important sets of tools: Critical appraisal tools and reporting guidelines. Critical appraisal tools facilitate the appraisal process and guide a consumer of evidence through an objective, analytical, evaluation process. Reporting guidelines, checklists of items that should be included in a publication or report, ensure that the project or guidelines are reported on with clarity, completeness, and transparency. Purpose The primary purpose of this paper is to help nurses understand the difference between critical appraisal tools and reporting guidelines. A secondary purpose is to help nurses locate the appropriate tool for the …

Retrieval Analysis Of Necropsy Total Hip Replacements: Considerations Beyond The Implant, Julie Alyse Lowell

Theses and Dissertations (ETD)

Introduction. Total hip arthroplasty (THA) surgery is one of the most commonly performed and successful orthopedic procedures in the United States. More than 300,000 primary THAs and 40,000 revision THAs performed in the United States every year. While the need for revision surgeries can stem from a variety of causes, there have been, to the author’s knowledge, no studies attempting to correlate the concentrations of certain inflammatory cytokines to metal ion concentrations found in the tissue surrounding the implant, amount of polyethylene wear, or strength of the interface of the modular taper. The purpose of this study was to begin …

Improving Vaccination Rates In Adults With Type Ii Diabetes In A Family Practice Setting: An Evidence-Based Quality Improvement Project, Ronda Gottlieb

Doctor of Nursing Practice

The purpose of this evidenced-based quality improvement project is to implement processes to facilitate providers’ adherence to the American Diabetes Association (2017), American Association of Clinical Endocrinologist (2015), and American College of Endocrinology (2015) immunization guidelines for adults with type II diabetes. Presently, diabetes is the 7th leading cause of death in the United States contributing to serious complications throughout the body as a result of poor glucose control. Adults with diabetes are at increased susceptibility to infectious disease because of hyperglycemia, poor glucose control, and decreased immunity. A protocol was created using The Four Pillars Transformation Program ™ to …

Dopamine Levels In The Brain Of Rat Models Of Human Rheumatoid Arthritis, Amelia Stinson

Theses & Dissertations

Research Focus. Rheumatoid arthritis (RA) is a chronic, debilitating, autoimmune disease that causes the destruction of bone tissue and the articular structures of joints. At least 30% of RA patient populations have cognitive impairment. Acidic dopamine (DA) is the principal neuroimmunotransmitter that links the central nervous system and peripheral nervous system together. The aim of the present study was to determine the levels of DA and its two acidic metabolites: 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in arthritic induced rats, and whether their levels vary across four different parts of the brain: amygdala (AMG), front cerebral cortex (CX), hippocampus …

An Investigation Of The Levels Of Pro-Inflammation Cytokines In The Brain Of Autoimmune Lewis Rats, Han Yang

Theses & Dissertations

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, which can cause cartilage and bone damage, as well as disability. A reported symptom of RA includes tissue inflammation disease and cognitive dysfunction. This study aimed to compare the concentration of selected cytokines in the cerebral cortex, hippocampus, hypothalamus, amygdala, and cerebellum of Lewis rats. Age and sex-matched Lewis rats were separated into two groups: control and adjuvant-induced RA. Twenty-eight days after the adjuvant injection, groups were sacrificed and brains dissected using the stereotaxic atlas of Paximos and Watson as a guide. Pro-inflammatory cytokines IL-1β, IL-6, and IL-23, plus the anti-inflammatory …

Clinical Cases In Endodontics; Chapter 1: Introduction, Takashi Komabayashi

Dental Medicine Faculty Publications

Chapter 1 of Clinical Cases in Endodontics, a problem-based text that presents a wide range of real cases in endodontics. Clinical Cases in Endodontics presents actual clinical cases, accompanied by academic commentary, that question and educate the reader about essential topics in endodontic therapy. It begins with sets of cases illustrating the most common diagnoses and the steps involved in preparing a treatment plan. Subsequent chapters continue in this style, presenting exemplary cases as the basis of discussing various treatment options, including nonsurgical root canal treatment, re-treatment, periapical surgery, internal and external resorption, emergencies and trauma, and treating incompletely developed …

Comprehensive Physical Therapy Management Of A Patient With Motor Control Deficits And Idiopathic Toe-Walking: A Case Report, Chelsey Hoglund, Kirsten Buchanan

Case Report Posters

Idiopathic toe-walking (ITW) describes patients who walk bearing most weight through their forefoot, in the absence of any known cause. Developmental coordination disorder (DCD) is a chronic condition involving impairments in gross motor, postural, and/or fine motor performance and affects the performance of movements necessary for daily living and academic tasks. Physical therapy intervention has been shown to result in improvements for patients with ITW and DCD, however, there are no known studies that investigate physical therapy intervention for patients with a diagnosis of both ITW and DCD. The purpose of this case report was to describe the comprehensive physical …

Outpatient Physical Therapy Management Of A Total Knee Arthroplasty With Severe Contralateral Knee Osteoarthritis: A Case Report, Michael Ikemura

Case Report Posters

Knee osteoarthritis (OA) is a common cause of severe pain, disability within the community, and dependence on others. In the U.S., a total knee arthroplasty (TKA) is one of the most commonly performed orthopedic procedures and 95% of them are attributed to OA. Following a TKA, pain and walking ability are the most important factors that need to be addressed. The purpose of this case report is to describe comprehensive PT management for a patient following a TKA with severe OA of the contralateral knee and report the outcomes.

The Use Of Therapeutic Exercise And Manual Therapy For A Patient Following Simultaneous Bilateral Total Knee Arthroplasty: A Case Report, Allison Maynes

Case Report Posters

Osteoarthritis (OA) is the most common joint disorder in the United States (US) and is the most common cause for a total knee arthroplasty (TKA) surgery. Approximately 670,000 TKA surgeries are performed annually in the US and it is estimated that one third are bilateral TKAs (BTKA) due to bilateral OA. Simultaneously, BTKA procedures consist of replacing both knees consecutively, in one operation, under one anesthesia. The purpose of this case report is to describe PT management, specifically therapeutic exercise and manual therapy, utilized for a patient who underwent simultaneous BTKA. This case report is needed based on the high …

Task-Oriented Training To Restore Independence In A Patient With Encephalitis In The Intensive Care Unit: A Case Report, Victoria Perez

Case Report Posters

Bacterial meningitis is a serious disease that causes acute inflammation of the meninges, the lining of the brain and spinal cord, which can result in significant morbidity and mortality. There are 15,000 to 25,000 cases in the US yearly and it is one of the top 10 causes of infection-related deaths worldwide. Bacterial meningitis is commonly complicated by encephalitis, inflammation of the brain parenchyma. 30% to 50% of survivors of bacterial encephalitis sustain neurological sequelae, which include memory loss, behavioral disorders, speech disorders, difficulty concentrating. The purpose of this case report was to investigate the use of task-oriented training to …